Agilawood-based fumigation bag and preparation method thereof

Abstract

The invention provides an agilawood-based fumigation bag and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine processing. The fumigation bag is prepared from the following raw materials in parts by weight: 5-15 parts of agilawood fruits, 5-15 parts of agilawood, 1-3 parts of agilawood leaves, 1-3 parts of cassia twigs, 3-6 parts of cloves, 5-10 parts of wormwood, 2-4 parts of thickleaf croton roots and 4-10 parts of Chinese prickly ash branches. When the agilawood-based fumigation bag is used for conditioning for 2 months according to a conditioning scheme, the symptoms such as emotion out-of-control, sleep disorder, muscle tension pain, hypertension, hyperlipidemia and hyperglycemia can be effectively relieved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine processing, and in particular to an agarwood-based fumigation bag and a preparation method thereof. Background Art

[0002] With the needs of fast-paced life in modern society, people are under long-term tension and stress, often experiencing mental excitability and mental fatigue, and even accompanied by emotional disorder, sleep disorders, muscle tension pain, etc. And with the improvement of people's living standards, the incidence of hypertension, high blood lipids and high blood sugar is also increasing. In severe cases, it will develop into cardiovascular and cerebrovascular infarction, obstruction, and infarction. The side effects of long-term medication will seriously damage the liver and kidneys. The reason is that it is due to insufficient positive energy, reduced self-regulation function, weak blood circulation, poor excretion of waste impurities in the body, and insufficient positive energy biochemical.

[0003] The skin is the largest organ in the human body, with a large area and many pores, and has multiple functions such as secretion, absorption, penetration, and excretion. Traditional Chinese medicine fumigation therapy utilizes this physiological characteristic of the skin, allowing the drug to be absorbed through the skin surface, penetrate the stratum corneum, and transport through the dermis to circulate in the blood and exert its pharmacological effect.

[0004] The current fumigation bags often cannot effectively exert the efficacy of fumigation bags due to the epidermal absorption mode and prescription preparation of fumigation treatment. Therefore, it is of great significance to study a fumigation bag based on agarwood and its preparation method so that the epidermis can fully absorb the drug efficacy and achieve the therapeutic effect. Summary of the invention

[0005] The object of the present invention is to provide a fumigation bag based on agarwood and a preparation method thereof, so as to solve the problem of poor therapeutic effect of fumigation bags in the prior art.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The present invention provides a fumigation bag based on agarwood, which is prepared from the following raw materials in parts by weight: 5-15 parts of agarwood fruits, 5-15 parts of agarwood wood, 1-3 parts of agarwood leaves, 1-3 parts of cassia twigs, 3-6 parts of cloves, 5-10 parts of wormwood, 2-4 parts of chicken bone incense, and 4-10 parts of pepper branches.

[0008] Preferably, the fumigation bag is prepared from the following raw materials in parts by weight: 8-12 parts of agarwood fruits, 8-12 parts of agarwood wood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 4-5 parts of cloves, 6-8 parts of wormwood, 3 parts of chicken bone incense, and 5-8 parts of pepper branches.

[0009] Preferably, the fumigation bag is prepared from the following raw materials in parts by weight: 10 parts of agarwood fruit, 10 parts of agarwood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 5 parts of cloves, 6 parts of wormwood, 3 parts of chicken bone incense, and 6 parts of pepper branches.

[0010] The present invention provides a method for preparing the above-mentioned agarwood-based fumigation bag, comprising the following steps:

[0011] (1) mixing the above raw materials according to the number of parts and then crushing them to obtain a mixed powder;

[0012] (2) The mixed powder and the solvent are mixed and then ultrasonically extracted, and the obtained supernatant is filtered, freeze-dried, sterilized, and packaged to obtain agarwood-based fumigation bags.

[0013] Preferably, in step (2), the frequency of ultrasonic extraction is 200-300W, and the time of ultrasonic extraction is 30-60min.

[0014] Preferably, in step (2), the solvent comprises n-hexane, methanol or ethyl acetate.

[0015] Preferably, in step (2), the mass volume ratio of the mixed powder to the solvent is 1 g: 5 to 15 mL.

[0016] Preferably, in step (2), the freeze-drying temperature is -40 to -30°C, and the freeze-drying time is 1 to 3 hours.

[0017] Preferably, in step (2), the sterilization is carried out by ethylene oxide sterilization, wherein the concentration of ethylene oxide is 300-500 mg / L, the temperature is 40-50° C., and the sterilization time is 4-6 hours.

[0018] Beneficial effects of the present invention:

[0019] (1) The present invention uses agarwood fruit, agarwood, agarwood leaves, cassia twigs, cloves, wormwood, chicken bone incense, and pepper branches as main raw materials to make agarwood-based fumigation bags, which can effectively relieve symptoms such as emotional instability, sleep disorders, muscle tension pain, hypertension, hyperlipidemia, and hyperglycemia.

[0020] (2) The present invention uses a suitable type of solvent to extract the effective ingredients from agarwood fruit, agarwood, agarwood leaves, cassia twigs, cloves, wormwood, chicken bone fragrance, and pepper branches, and freeze-drying and sterilization treatment can ensure the efficacy of the effective ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The results are those obtained by filtering the supernatant with a 0.22 μm filter membrane and then performing gas chromatography-mass spectrometry analysis in Examples 1 to 3. DETAILED DESCRIPTION

[0022] The present invention provides a fumigation bag based on agarwood, which is prepared from the following raw materials in parts by weight: 5-15 parts of agarwood fruits, 5-15 parts of agarwood wood, 1-3 parts of agarwood leaves, 1-3 parts of cassia twigs, 3-6 parts of cloves, 5-10 parts of wormwood, 2-4 parts of chicken bone incense, and 4-10 parts of pepper branches.

[0023] In the present invention, the fumigation bag is prepared from the following raw materials in parts by weight: 8-12 parts of agarwood fruits, 8-12 parts of agarwood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 4-5 parts of cloves, 6-8 parts of wormwood, 3 parts of chicken bone incense, and 5-8 parts of pepper branches.

[0024] In the present invention, the fumigation bag is prepared from the following raw materials in parts by weight: 10 parts of agarwood fruit, 10 parts of agarwood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 5 parts of cloves, 6 parts of wormwood, 3 parts of chicken bone incense, and 6 parts of pepper branches.

[0025] The present invention provides a method for preparing the above-mentioned agarwood-based fumigation bag, comprising the following steps:

[0026] (1) mixing the above raw materials according to the number of parts and then crushing them to obtain a mixed powder;

[0027] (2) The mixed powder and the solvent are mixed and then ultrasonically extracted, and the obtained supernatant is filtered, freeze-dried, sterilized, and packaged to obtain agarwood-based fumigation bags.

[0028] In the present invention, in step (2), the frequency of ultrasonic extraction is 200-300W, preferably 220-280W, and more preferably 250W; the time of ultrasonic extraction is 30-60min, preferably 35-55min, and more preferably 40-50min.

[0029] In the present invention, in step (2), the solvent comprises n-hexane, methanol or ethyl acetate, preferably n-hexane or methanol, and more preferably n-hexane.

[0030] In the present invention, in step (2), the mass volume ratio of the mixed powder to the solvent is 1 g: 5 to 15 mL, preferably 1 g: 8 to 12 mL, and more preferably 1 g: 10 mL.

[0031] In the present invention, in step (2), the freeze-drying temperature is -40 to -30°C, preferably -35°C, and the freeze-drying time is 1 to 3 hours, preferably 1.5 to 2.5 hours, and more preferably 2 hours.

[0032] In the present invention, in step (2), sterilization is carried out by ethylene oxide sterilization, wherein the concentration of ethylene oxide is 300-500 mg / L, preferably 350-450 mg / L, and more preferably 400 mg / L; the temperature is 40-50°C, preferably 45°C, and the sterilization time is 4-6 hours, preferably 4.5-5.5 hours, and more preferably 5 hours.

[0033] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0034] Example 1

[0035] Prepare the raw materials according to the following weight proportions: 10 parts of agarwood fruits, 10 parts of agarwood wood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 5 parts of cloves, 6 parts of mugwort, 3 parts of chicken bone incense, and 6 parts of pepper branches.

[0036] The above raw materials are mixed according to weight parts, and then crushed into powder to obtain a mixed powder; the mixed powder and n-hexane are mixed evenly (according to the mass volume ratio of the mixed powder and n-hexane being 1 g: 10 mL), and then ultrasonic extraction is carried out at a frequency of 250 W, and the supernatant obtained is filtered with a 0.22 μm filter membrane. After the membrane filtration is completed, it is placed in a freeze drying box at a temperature of -35°C and freeze-dried for 2 hours, and then sterilized by ethylene oxide sterilization method, and the sterilization conditions are: the concentration of ethylene oxide is 400 mg / L, the temperature is 45°C, and the sterilization time is 5 hours. Finally, the sterilized powder is packaged according to the specification of 12 g per bag to obtain a fumigation bag based on agarwood.

[0037] Example 2

[0038] The difference from Example 1 is that the solvent is methanol, and other conditions are the same.

[0039] Example 3

[0040] The difference from Example 1 is that the solvent is ethyl acetate, and other conditions are the same.

[0041] Example 4

[0042] The difference from Example 1 is that the weight proportion of the raw materials is: 15 parts of agarwood fruits, 5 parts of agarwood wood, 1 part of agarwood leaves, 1 part of cassia twigs, 3 parts of cloves, 5 parts of wormwood, 2 parts of chicken bone incense, and 10 parts of pepper branches, and other conditions are the same.

[0043] Example 5

[0044] The difference from Example 1 is that the weight proportion of the raw materials is: 5 parts of agarwood fruits, 15 parts of agarwood, 3 parts of agarwood leaves, 3 parts of cassia twigs, 3 parts of cloves, 10 parts of wormwood, 4 parts of chicken bone incense, and 5 parts of pepper branches, and other conditions are the same.

[0045] Comparative Example 1

[0046] The difference from Example 1 is that the weight proportion of the raw materials is: 2 parts of agarwood fruit, 2 parts of agarwood, 4 parts of cassia twig, 8 parts of clove, 10 parts of wormwood, 5 parts of chicken bone incense, and 10 parts of Zanthoxylum bungeanum, and other conditions are the same.

[0047] In Examples 1 to 3, the supernatant was filtered with a 0.22 μm filter membrane and then subjected to gas chromatography-mass spectrometry (GC-MS) analysis. The GC-MS experimental conditions were as follows: column type DB-5MS (30 m×250 μm×0.25 μm), injection volume: 5 μL, carrier gas high-purity helium, split flow rate 10 mL·min -1 , injection port temperature was 250℃, split ratio was 10:1; chromatographic condition 1 was initial temperature 50℃, at 20℃·min -1 Raise the temperature to 170℃ and hold for 3min at 2℃·min -1 Raise the temperature to 210℃, hold for 2min, and adjust the temperature at 7℃·min -1 The temperature was raised to 300°C and maintained for 2 min. MS conditions: EI source ionization, ionization energy 70.0 eV, ion source temperature 230°C, ion transmission temperature 250°C, mass scanning range m / z 40-550. The analysis results are shown in Figure 1 .

[0048] from Figure 1 It can be seen that when n-hexane is used as the solvent, the peak capacity after ultrasonic extraction is good and the number of ion peaks increases, which indicates that the use of a suitable type of solvent can extract the effective components in the raw materials.

[0049] Conditioning plan: Place 5 fumigation bags in a container filled with water, add 2000mL of water, and then heat to boiling to produce mist. Then place the human body in the mist and absorb the mist through the skin, which can enable the effective ingredients to reach the body directly and achieve the purpose of conditioning, allowing the body's wind, cold, dampness and toxins to be excreted. Each conditioning time is 30 minutes, three times a week, one month as a course of treatment, and two courses of treatment will be effective.

[0050] Patients with symptoms of emotional disorder, sleep disorder, muscle tension pain, hypertension, hyperlipidemia, and hyperglycemia were selected. Patients with one or more of the above symptoms could be tested. A total of 100 patients were selected and conditioned for two months according to the above conditioning plan. The results were calculated according to the conditioning efficiency. See Table 1:

[0051] Table 1 Conditioning results of agarwood-based fumigation bags prepared in Examples 1 to 5 and Comparative Example 1

[0052] serial number Effectiveness of conditioning Example 1 99％ Example 2 95％ Example 3 93％ Example 4 92％ Example 5 90％ Comparative Example 1 75％

[0053] It can be seen from Table 1 that the conditioning effect of the agarwood-based fumigation bag prepared in the present invention can reach more than 90%.

[0054] As can be seen from the above embodiments, the present invention provides a fumigation bag based on agarwood and a preparation method thereof. The fumigation bag of the present invention is prepared from the following raw materials in parts by weight: 5-15 parts of agarwood fruit, 5-15 parts of agarwood, 1-3 parts of agarwood leaves, 1-3 parts of cassia twigs, 3-6 parts of cloves, 5-10 parts of wormwood, 2-4 parts of chicken bone incense, and 4-10 parts of pepper branches. The fumigation bag based on agarwood of the present invention is conditioned for 2 months according to the conditioning scheme, which can relieve symptoms such as emotional instability, sleep disorders, muscle tension pain, hypertension, hyperlipidemia, and hyperglycemia.

[0055] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A fumigation bag based on agarwood, characterized in that: The fumigation bag is prepared from the following raw materials in parts by weight: 5-15 parts of agarwood fruits, 5-15 parts of agarwood wood, 1-3 parts of agarwood leaves, 1-3 parts of cassia twigs, 3-6 parts of cloves, 5-10 parts of wormwood, 2-4 parts of chicken bone incense, and 4-10 parts of pepper branches.

2. The agarwood-based fumigation bag according to claim 1, characterized in that: The fumigation bag is prepared from the following raw materials in parts by weight: 8-12 parts of agarwood fruits, 8-12 parts of agarwood wood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 4-5 parts of cloves, 6-8 parts of wormwood, 3 parts of chicken bone incense, and 5-8 parts of pepper branches.

3. The agarwood-based fumigation bag according to claim 2, characterized in that: The fumigation bag is prepared from the following raw materials in parts by weight: 10 parts of agarwood fruits, 10 parts of agarwood wood, 2 parts of agarwood leaves, 2 parts of cassia twigs, 5 parts of cloves, 6 parts of wormwood, 3 parts of chicken bone incense, and 6 parts of pepper branches.

4. The method for preparing the agarwood-based fumigation bag according to any one of claims 1 to 3, characterized in that: The steps include: (1) mixing the above raw materials according to the number of parts and then crushing them to obtain a mixed powder; (2) The mixed powder and the solvent are mixed and then ultrasonically extracted, and the obtained supernatant is filtered, freeze-dried, sterilized, and packaged to obtain agarwood-based fumigation bags.

5. The method for preparing the agarwood-based fumigation bag according to claim 4, characterized in that: In the step (2), the frequency of ultrasonic extraction is 200-300W, and the time of ultrasonic extraction is 30-60min.

6. The method for preparing the agarwood-based fumigation bag according to claim 5, characterized in that: In the step (2), the solvent comprises n-hexane, methanol or ethyl acetate.

7. The method for preparing the agarwood-based fumigation bag according to claim 5 or 6, characterized in that: In the step (2), the mass volume ratio of the mixed powder and the solvent is 1 g: 5 to 15 mL.

8. The method for preparing the agarwood-based fumigation bag according to claim 7, characterized in that: In the step (2), the freeze-drying temperature is -40 to -30°C, and the freeze-drying time is 1 to 3 hours.

9. The method for preparing the agarwood-based fumigation bag according to claim 6 or 8, characterized in that: In the step (2), the sterilization is carried out by ethylene oxide sterilization, wherein the concentration of ethylene oxide is 300-500 mg / L, the temperature is 40-50° C., and the sterilization time is 4-6 hours.

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