A microneedle real-time imaging and drug delivery system

Abstract

The application discloses a microneedle real-time imaging and drug delivery system, which comprises a microneedle array disc module, an excitation power supply module, a signal processing module, a control module, a data transmission module and an upper computer module. The microneedle array disc module is used for releasing drugs into a living body and collecting real-time response electrical signals. The excitation power supply module is used for receiving and providing excitation electrical signals to the microneedle array disc module according to instructions from the control module. The signal processing module is used for pre-processing the real-time response electrical signals. The control module is used for secondary processing the pre-processing results. The data transmission module is used for transmitting the secondary processing results output by the control module to the upper computer module. The upper computer module is used for receiving and deeply processing the secondary processing results. The application can generate images by processing the monitored real-time response electrical signals, so that a user can observe the related conditions of the subcutaneous tissue of the living body in real time, and the drug delivery effect is better.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of biological subcutaneous drug delivery, and in particular to a microneedle real-time imaging and drug delivery system. BACKGROUND

[0002] Microneedles are a new type of drug delivery technology that has attracted much attention in recent years, which refers to a method of drug delivery on the surface of the skin to make drugs enter the body circulation through the skin to produce systemic or local therapeutic effect. It is used for clinical trial stage of vaccination, treatment of diabetes, hair regeneration, treatment of skin cancer, etc. Existing drug delivery microneedles are mainly divided into solid microneedles, coated microneedles, hollow microneedles, dissolvable microneedles and hydrogel microneedles according to the drug introduction mode. The existing microneedle drug delivery system has the following problems: most of the microneedles have insufficient drug loading due to their structure and drug delivery mode; solid microneedles have high mechanical strength during insertion, which can easily cause the tip to break and leave fragments in the human body, causing safety hazards; existing dissolvable microneedles are mainly made of biodegradable materials, which have relatively low hardness and poor mechanical strength of the tip, making it difficult to penetrate the skin; the porous drug delivery microneedles are interconnected, making it difficult to achieve real-time monitoring function and provide accurate treatment feedback; most drug delivery microneedles cannot meet the technical requirements of personalized drug delivery in precision medicine.

[0003] It can be seen that there are still many problems in the prior art, and the existing biological subcutaneous drug delivery technology needs to be improved to overcome the defects of the prior art. SUMMARY

[0004] Therefore, in order to solve the above problems in the prior art, the present application provides a microneedle real-time imaging and drug delivery system.

[0005] The present application solves the above problems by the following technical means:

[0006] A microneedle real-time imaging and drug delivery system, comprising:

[0007] The micro-needle array disc module is used for releasing drugs into a living body and receiving an external applied excitation electric signal; and collecting a real-time response electric signal generated by a tissue in the living body due to excitation by the excitation electric signal; an excitation power supply module, a signal processing module, and a control module; the excitation power supply module is used for receiving and providing the excitation electric signal to the micro-needle array disc module according to an instruction issued by the control module; the signal processing module is used for receiving and pre-processing the real-time response electric signal collected by the micro-needle array disc module and outputting a pre-processing result; the control module is used for controlling and processing the size of the excitation electric signal provided by the excitation power supply module, receiving the pre-processing result output by the signal processing module, and performing secondary processing on the pre-processing result and outputting a secondary processing result; a data transmission module is used for transmitting the secondary processing result output by the control module to the host computer module; and the host computer module is used for receiving and displaying the result transmitted by the data transmission module, and performing deep processing on the received result and outputting a deep processing result.

[0008] The micro-needle array disc module, the excitation power supply module, the signal processing module, the control module, the data transmission module, the host computer module, and the server module can be combined to monitor the real-time response electric signal of a subcutaneous tissue in a living body during a micro-needle drug delivery process in real time, so that an image can be generated by processing the monitored real-time response electric signal, and a user can observe the related conditions of the subcutaneous tissue in real time, thereby achieving a better drug delivery effect.

[0009] Further, the micro-needle array disc module comprises:

[0010] The excitation micro-needle unit is used for receiving the excitation electric signal provided by the excitation power supply module; and the collection micro-needle unit is used for releasing drugs into a living body and collecting the real-time response electric signal.

[0011] Further, the excitation micro-needle unit is two, and the collection micro-needle unit is one or more; the two excitation micro-needle units and the one or more collection micro-needle units are distributed on the front surface of the micro-needle array disc module.

[0012] It should be noted that the purpose of the two excitation microneedle units in the present application is to apply excitation electrical signals (including but not limited to applying voltage or directly inputting current, etc.) to the excitation microneedle units by the excitation power module. The two excitation microneedle units can be regarded as two excitation electrodes. When the excitation electrical signals are injected into the imaging target, the two excitation electrodes are in a relative position. The use of two excitation electrodes to input excitation electrical signals (preferably using input current) has the advantages of ensuring that the current excitation is distributed in the measured object and the input current field is symmetrical, which helps to reduce measurement errors. When a single excitation electrode is used, the electrode may be polarized, affecting the accuracy of the measurement results. Therefore, the present application preferably adopts the scheme of arranging two excitation microneedle units.

[0013] Further, the excitation microneedle unit comprises a first conductive base and a first base, the first conductive base is arranged on the first base, the first conductive base and the first base are integrally cast, and the surfaces of the first conductive base and the first base are covered with a metal layer. Further, the collection microneedle unit comprises a second conductive base, a second base, a medicine inlet hole, a soluble drug-loaded needle tip, and an electrical signal collection component, the second conductive base is arranged on the second base, the medicine inlet hole is arranged at the bottom of the second conductive base, and the soluble drug-loaded needle tip is arranged inside the second conductive base; the electrical signal collection component is arranged at the bottom of the second base, the second conductive base and the second base are integrally cast, and the surfaces of the second conductive base and the second base are covered with a metal layer. To make the description more

[0014] Conveniently, in this paragraph, the first conductive base and the second conductive base are collectively referred to as a conductive base, and the first base and the second base are collectively referred to as a base. The preparation method of the excitation microneedle unit and the collection microneedle unit of the present application both adopt high polymer material casting to form high polymer solid microneedles, and adopt dip coating method to uniformly coat a metal layer on the conductive base and its base. As a preferred embodiment, the metal layer is an inert metal layer.

[0015] Further, the signal processing module uses an amplification chip combined with a first-order high / low-pass passive filter network to pre-process the received real-time response electrical signals and deliver the pre-processing results to the control module; the signal processing module is one or more, and one signal processing module corresponds to one collection microneedle unit. The present application uses an amplification chip and a first-order high / low-pass passive filter network to pre-process the response electrical signals. First, the high-pass filter network filters out the polarization voltage of the electrode to prevent the saturation of the amplifier. After amplification by the chip, the low-pass filter network is used to remove high-frequency noise and reduce common-mode interference.

[0016] Further, the control module adopts a first subtractor, a later-stage voltage amplification circuit and an analog-to-digital converter, and the pre-processing result delivered by the signal processing module is sequentially subjected to secondary processing by the first subtractor, the later-stage voltage amplification circuit and the analog-to-digital converter, and the secondary processing result is delivered to the data transmission module. Through the setting of the control module, the pre-processing result processed by the signal processing module is subjected to amplification by a plurality of times through the first subtractor, and then enters the later-stage voltage amplification circuit, the amplified analog signal is converted into a digital signal through the analog-to-digital converter, and finally the digital signal is delivered to the data transmission module.

[0017] Further, the data transmission module adopts a wireless transmission mode, and is mainly used for transmitting data between the control module and the upper computer.

[0018] Further, the signal processing module, the excitation power supply module, the control module and the data transmission module are integrated on the back of the microneedle array disc module.

[0019] Further, the microneedle real-time imaging and drug delivery system further comprises a server module connected with the data transmission module, for receiving and storing the deep processing result output by the upper computer module.

[0020] The first conductive base, the first base, the second conductive base, the second base, the medicine inlet hole and the soluble drug-loaded needle tip are arranged in the structure, when exposed to the body fluid in the living body, the soluble drug-loaded needle tip is dissolved to form charged ions, which move directionally under the action of an external electric field, thereby forming an electric current (i.e., an electric signal). Due to the existence of the first conductive base, the first base, the second conductive base, the second base, the medicine inlet hole and the soluble microneedle, the electric signal propagation path is short, interference and attenuation are reduced, and the measurement accuracy and sensitivity are greatly improved.

[0021] The soluble drug-loaded needle tip cooperates with the second conductive base to avoid the collapse of the microneedle tip during the process of penetrating into the living body and remaining in the skin, and the second conductive base plays a supporting role to ensure that the soluble drug-loaded needle tip can smoothly complete the penetration action.

[0022] Each collection microneedle unit in the microneedle array disc module is connected with one signal processing module, in the mode that the excitation power module excites the excitation microneedle unit, the microneedle array disc module can collect the real-time response electrical signal in the treatment process in real time, and after processing and transmission of the signal processing module, the control module and the data transmission module, an electrical signal image is formed in the host computer module, which assists the doctor in evaluating the treatment effect. And the second conductive base of the application leaves a medicine inlet hole at the bottom, which can effectively solve the problem of small microneedle drug delivery amount and cannot continuous drug delivery. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiment description. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative labor.

[0024] Figure 1 The structural diagram of the microneedle real-time imaging and drug delivery system provided by the present application is shown in the figure.

[0025] Figure 2 The schematic diagram of the microneedle array disc module provided by the embodiment of the present application is shown in the figure.

[0026] Figure 3 The schematic diagram of the collection microneedle unit provided by the embodiment of the present application is shown in the figure.

[0027] Explanation of reference signs:

[0028] Collection microneedle unit-11, excitation microneedle unit 12,

[0029] Second conductive base-111, second base-112,

[0030] Medicine inlet hole-113, soluble drug-loaded needle tip-114. DETAILED DESCRIPTION

[0031] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the technical solutions of the present application will be described in detail below in combination with the drawings and specific embodiments. It should be pointed out that the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0032] EMBODIMENT

[0033] The present application will be described in more detail as follows:

[0034] As shown in Figure 1 and Figure 2 A micro-needle real-time imaging and drug delivery system, comprising:

[0035] A micro-needle array disc module for releasing drugs into a living body and receiving an excitation electrical signal applied externally; and collecting a real-time response electrical signal generated by the tissue in the living body due to the excitation of the excitation electrical signal. It should be noted that the shape of the micro-needle array disc module includes but is not limited to: rectangular, circular, square, triangular, rhombic, elliptical and other planar structures.

[0036] As a preferred embodiment, the micro-needle array disc module comprises:

[0037] An excitation micro-needle unit 12 for receiving an excitation electrical signal provided by the excitation power supply module. As a preferred embodiment, the excitation micro-needle unit 12 comprises a first conductive base (not shown) and a first base (not shown), and the first conductive base is arranged on the first base. As a preferred embodiment, the first conductive base and the first base are integrally cast, and the surfaces of the first conductive base and the first base are covered with a metal layer. As a preferred embodiment, the metal layer is an inert metal layer.

[0038] It should be noted that the role of the excitation micro-needle unit 12 in the system described in the present application is to provide an excitation electrical signal to the subcutaneous tissue of a living body. By pre-setting parameters, an excitation electrical signal (which can be selected according to actual needs, including but not limited to: voltage, current, etc.) is applied to the excitation micro-needle unit 12 by an external module (i.e. the excitation power supply module described below in this embodiment), thereby exciting the subcutaneous tissue of the living body to generate impedance, and a real-time response electrical signal can be generated in the corresponding subcutaneous tissue of the living body.

[0039] As shown in Figure 3 A collection micro-needle unit 11 for releasing drugs into a living body and collecting the real-time response electrical signal; as a preferred embodiment, the collection micro-needle unit 11 comprises a second conductive base 111, a second base 112, a drug inlet hole 113, a soluble drug-loaded needle tip 114, and an electrical signal collection component (not shown), wherein the second conductive base 111 is arranged on the second base 112, the drug inlet hole 113 is arranged at the bottom of the second conductive base 111, and the soluble drug-loaded needle tip 114 is arranged inside the second conductive base 111. As a preferred embodiment, the electrical signal collection component is arranged at the bottom of the second base 112. As a preferred embodiment, the second conductive base 111 and the second base 112 are integrally cast, and the surfaces of the second conductive base 111 and the second base 112 are covered with a metal layer. As a preferred embodiment, the metal layer is an inert metal layer.

[0040] It should be noted that there are many preparation methods of the collection microneedle unit 11 and the excitation microneedle unit 12 in the prior art, and the particularity of the present application lies in: according to the structure of human skin and the material of microneedles, comprehensively considering the factors such as the risk of microneedle fracture, the pain of soluble microneedles penetrating the skin and the efficiency of drugs entering the human body, the specifications of related components are as follows: the length of the collection microneedle unit 11 and the excitation microneedle unit 12 is about 300 μm to 1000 μm, the diameter of the first and second conductive bases 111 is about 300 μm, the taper of the soluble drug-loaded needle tip 114 is less than about 5°, and the needle center distance is about 300 μm to 2000 μm. The first conductive base and the first base, the second conductive base 111 and the second base 112 can be integrally formed by biodegradable polymer materials, which include but are not limited to one or more of polylactic acid, levorotatory polylactic acid and polyglycolic acid; the soluble drug-loaded needle tip 114 is one or more materials with drug loading capacity including but not limited to polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) (the material dissolves when it contacts with interstitial fluid, the loaded drug molecules are locally released, and the problem of needle fracture and residual in the skin is solved).

[0041] In the preparation process of the collection microneedle unit 11 and the excitation microneedle unit 12, the first conductive base and the first base, the second conductive base 111 and the second base 112 are preferably electrochemically polymerized, and materials including but not limited to poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, polythiophene, polyaniline, polypyrrole and the like are used as ion-electron transducers and deposited on the first and second conductive bases 111, and the electrochemical polymerization is preferably carried out by cyclic voltammetry, constant potential method, constant current method, dynamic potential scanning method or pulse method for 20-1000 min.

[0042] It should be noted that the role of the collection microneedle unit 11 in the system described in the present application is:

[0043] First, the drug is released under the skin of the organism, and the drug is delivered into the organism under the skin by the action of the soluble drug-loaded needle tip 114 in the collection microneedle unit 11. The microneedle array disc module is attached to the body surface of the organism, and the soluble drug-loaded needle tip 114 penetrates the stratum corneum and pierces the skin epidermis, and the soluble drug-loaded needle tip 114 releases the drug it carries, achieving the purpose of drug delivery. The bottom of the second conductive base 111 in the collection microneedle unit 11 is provided with the drug inlet hole 113, which is arranged to facilitate the addition of drug amount at any time according to actual needs, solving the problem of the current market microneedles that cannot continuously give multiple doses, so as to facilitate personalized and diversified drug administration.

[0044] Second, the real-time response electrical signal is collected. Due to the interaction between the excitation microneedle unit 12 and the excitation power module, the organism is excited by the excitation electrical signal, the tissue in the organism generates impedance, and then the real-time response electrical signal is generated, which is the real-time response electrical signal collected by the collection microneedle unit 11. There are many methods in the prior art to collect the real-time response electrical signal of the tissue in the organism, and the electrical signal collection component in the embodiment is preferably a single-chip microcomputer.

[0045] As a preferred embodiment, the excitation microneedle unit 12 is two, and the collection microneedle unit 11 is one or more.

[0046] The two excitation microneedle units 12 and one or more collection microneedle units 11 are distributed on the front surface of the microneedle array disc module.

[0047] It should be noted that the purpose of using two excitation microneedle units 12 in the present application is to apply an excitation electrical signal (including but not limited to applying a voltage or directly inputting a current, etc.) to the excitation microneedle unit 12 by the excitation power module. We can regard the two excitation microneedle units 12 as two excitation electrodes, and when the excitation electrical signal is injected into the imaging target, the two excitation electrodes are in a relative position. The advantages of using two excitation electrodes to input the excitation electrical signal (preferably using input current) are: to ensure that the current excitation is distributed in the measured object, and the input current field is symmetrical, which helps to reduce measurement error; when using a single excitation electrode, the electrode may be polarized, affecting the accuracy of the measurement result. Therefore, the present application preferably adopts the scheme of providing two excitation microneedle units 12.

[0048] As Figure 2As shown, the two stimulating microneedle units 12 and one or more collecting microneedle units 11 are distributed on the front surface of the microneedle array disc. It should be noted that the arrangement of the stimulating microneedle units 12 and the collecting microneedle units 11 is not particularly required. In addition, the stimulating microneedle units 12 and the collecting microneedle units 11 are in the form of a needle tip or a needle tip-like structure, so as to be able to pierce the epidermis of a living body.

[0049] The stimulating power module is used to receive and provide stimulating electrical signals to the microneedle array disc module according to the instructions from the control module; the signal processing module is used to receive and pre-process the real-time response electrical signals collected by the microneedle array disc module, and output the pre-processing results; the control module is used to control and process the size of the stimulating electrical signals provided by the stimulating power module, receive the pre-processing results output by the signal processing module, and perform secondary processing on the pre-processing results, and output the secondary processing results; the data transmission module is used to transmit the secondary processing results output by the control module to the host computer module; the host computer module is used to receive and display the results transmitted by the data transmission module, and perform deep processing on the received results and output the deep processing results.

[0050] It should be noted that the stimulating power module includes but is not limited to: a micro battery, a switch, a resistor and a wire, which is connected to the control module and provides power for the control module, and provides a current or voltage signal for the stimulating microneedle units 12 during the drug delivery process. In this embodiment, the stimulating current ranges from 10 to 60 μA, the current frequency is in the low frequency range of 1-10 kHz, the battery capacity is 100-2000 mAh, the resistance value is 0-10 KΩ, the battery diameter is about 4-12 mm, and the thickness is about 1-5 mm.

[0051] As preferred, the signal processing module adopts an amplification chip combined with a first-order high / low-pass passive filter network to pre-process the received real-time response electrical signals and deliver the pre-processing results to the control module. The amplification chip and the first-order high / low-pass passive filter network are used to pre-process the response electrical signals, the real-time response electrical signals are first filtered through a high-pass filter network to remove the polarization voltage of the electrode to prevent the saturation of the amplifier, and then amplified through a chip, and then filtered through a low-pass filter network to remove high-frequency noise and reduce common-mode interference. It should be noted that in this embodiment, each collecting microneedle unit 11 corresponds to a signal processing module, and all signal processing modules are connected to the control module to deliver the pre-processing results to the control module.

[0052] It should be noted that the control module is used to control and process the size of the excitation electrical signal provided by the excitation power module, and receive the preprocessing result output by the signal processing module, and perform secondary processing on it, and output the secondary processing result. The control module is responsible for controlling the parameter adjustment of the excitation power module, and controlling the excitation power module to inject the excitation electrical signal to the excitation microneedle unit 12, etc., while also controlling the real-time response electrical signal collected by the collection microneedle unit 11, and performing measurement and processing, etc., that is, receiving the preprocessing result output by the signal processing module, and performing secondary processing on it, and outputting the secondary processing result. To ensure the accuracy and stability of the real-time response electrical signal (high precision and fast response to realize real-time imaging). The specific form of the control module includes but is not limited to: microcontroller, analog circuit, etc.

[0053] In this embodiment, as a preferred, the control module adopts a first-order subtractor, a later-stage voltage amplification circuit and an analog-to-digital converter. The preprocessing result delivered by the signal processing module is sequentially subjected to secondary processing by the first-order subtractor, the later-stage voltage amplification circuit and the analog-to-digital converter, and the secondary processing result is delivered to the data transmission module. Through the setting of the control module, the preprocessing result processed by the signal processing module is subjected to first-order subtraction and amplification, enters the later-stage voltage amplification circuit, the amplified analog signal is converted into a digital signal by the analog-to-digital converter, and finally the digital signal is delivered to the data transmission module.

[0054] The data transmission module is used to transmit the secondary processing result output by the control module to the host computer module; it should be noted that the specific form of the data transmission module includes but is not limited to: Bluetooth transmission, WiFi transmission, NFC transmission, etc., and in this embodiment, the Bluetooth transmission mode is preferred.

[0055] The host computer module is used to receive and display the result delivered by the data transmission module, and to perform deep processing on the received result and output the deep processing result. As known from the above, the system provided in this embodiment is continuously subjected to the "excitation-collection" cycle, so the collection microneedle unit 11 continuously and uninterruptedly collects the real-time response electrical signal, and correspondingly, there will be images in different states in the host computer module continuously. After collecting a certain number of images, the host computer module will perform deep processing on them. In this embodiment, the D-bar algorithm or the layer stripping method is preferably used to solve the inverse problem of electrical impedance distribution, and the image is reconstructed. Finally, the electrical impedance distribution of each point on the tomography is reflected in the grayscale image or RGB color image, the features of the image are extracted and uploaded to the server, that is, the deep processing result is delivered to the server.

[0056] A server module is configured to receive and store the deep processing result output by the host computer module, and is connected with the data transmission module. The server module is mainly configured to receive and store the deep processing result. It should be noted that the server module includes but is not limited to a local server, a virtual server, a big data cloud platform, etc. The deep processing result output by the host computer can be compared with the existing relevant result data in the server module. When it is found that the comparison result is closer to the situation, the server module sends the closer situation to the control module through the data transmission module. The control module changes the excitation electric signal of the excitation power module according to the closer situation output by the server module, and adds the medicine through the medicine inlet hole 113 as needed, so as to help people to implement more accurate medicine sending and administration scheme.

[0057] Preferably, the signal processing module, the excitation power module, the control module and the data transmission module are integrated on the back of the microneedle array disc module.

[0058] In order to make the application more easily understood, the working process of the real-time imaging and drug delivery system of the microneedle according to the application is briefly described as follows:

[0059] Firstly, a microneedle array disc module is attached to the body surface. All the excitation microneedle units 12 and the collection microneedle units 11 on the microneedle array disc module penetrate the stratum corneum and pierce into the epidermis layer, and the soluble drug-loaded needle tip 114 on the collection microneedle unit 11 releases the internal medicine. It should be noted that the medicine carried by the soluble drug-loaded needle tip 114 according to the application includes but is not limited to one or more combinations of anticancer drugs, analgesics, contraceptives, vaccines, proteins, peptides, polysaccharide genes, antibodies, local anesthetics, insulin, etc.

[0060] Then, excitation and collection are performed. In one excitation-collection cycle, the excitation power module applies an excitation electric signal to the excitation microneedle unit 12. At the same time, the collection microneedle unit 11 collects the real-time response electrical signal. The real-time response electrical signal at this time is an analog signal, which enters the signal processing module.

[0061] The real-time response electrical signal collected by each collection microneedle unit 11 enters the corresponding signal processing module for pre-processing. The pre-processing process is as follows: first, the polarization voltage of the electrode is filtered out through a high-pass filter network to prevent the saturation of the amplifier. Then, after being amplified by a chip, the high-frequency noise is removed through a low-pass filter network to reduce common-mode interference. The preferred chip in this embodiment is an AD620 amplification chip.

[0062] The analog signal formed after pre-processing enters the control module next, and the secondary processing is performed in the control module, and the process of the secondary processing is: sequentially passing through a first subtractor, a later-stage voltage amplification circuit and a high-precision analog-to-digital converter. In the embodiment, preferably, the analog signal formed after pre-processing passes through the first subtractor and is amplified by about 48 times, then enters the later-stage voltage amplification circuit, and the analog signal amplified by 10 times passes through the high-precision analog-to-digital converter to be converted into a digital signal, the digital signal is transmitted to the host computer module through the data transmission module, and a high-resolution relational image is generated in the host computer module in real time, so that the detection and continuous monitoring of the real-time response electrical signal during the drug administration process are realized. Preferably, after 1000 times of excitation-acquisition cycles, the host computer module solves the inverse problem of the electrical impedance distribution by using a D-bar algorithm or a layer stripping method, and reconstructs the image, finally, the electrical impedance distribution of each point on the tomography is reflected by using a grayscale image or an RGB color image, the features of the image are extracted and uploaded to the server module.

[0063] The micro-needle array disc module, the excitation power supply module, the signal processing module, the control module, the data transmission module, the host computer module and the server module are combined, so that the real-time response electrical signal of the biological subcutaneous tissue during the micro-needle drug administration process in the biological body can be monitored in real time, the real-time response electrical signal monitored is processed to generate an image, and the user can observe the related conditions of the biological subcutaneous tissue in real time, so that a better drug administration effect is achieved.

[0064] The micro-structure of the first conductive base, the first base, the second conductive base 111, the second base 112, the drug inlet hole 113 and the soluble drug-loaded needle tip 114 and the electrochemical polymerization of the conductive polymer material occur, when exposed to the body fluid in the biological body, the electrolyte in the body is dissolved to form charged ions (as known from the above, the first conductive base, the first base, the second conductive base 111, the second base 112, the drug inlet hole 113 and the soluble drug-loaded needle tip 114 are integrally cast from a conductive polymer material, and the first conductive base and the second conductive base 111 are subjected to electrochemical polymerization operation, so when the first conductive base, the first base, the second conductive base 111, the second base 112, the drug inlet hole 113 and the soluble drug-loaded needle tip 114 are exposed to the body fluid, the electrolyte in the body is dissolved to form charged ions), under the action of an external electric field (the external electric field is the excitation electrical signal applied to the excitation micro-needle unit by the excitation power supply module), directional movement is formed (the external electric field is the excitation electrical signal applied to the excitation micro-needle unit by the excitation power supply module), thereby forming an electric current (i.e. an electrical signal), due to the existence of the micro-structure of the first conductive base, the first base, the second conductive base 111, the second base 112, the drug inlet hole 113 and the soluble micro-needle, the electrical signal propagation path is short, the interference and attenuation are reduced, and the measurement accuracy and sensitivity are greatly improved.

[0065] The soluble drug-loaded needle tip 114 cooperates with the second conductive base 111 to avoid the collapse of the microneedle tip during the process of piercing into the organism and remaining in the skin, and the second conductive base 111 plays a supporting role to ensure that the soluble drug-loaded needle tip 114 can smoothly complete the action of piercing.

[0066] Each collection microneedle unit 11 in the microneedle array disc module is connected with one signal processing module, and the microneedle array disc module can collect the electrical signals in real time during the treatment process in the mode of the excitation power module exciting the excitation microneedle unit 12, and the electrical signal image is formed on the host computer module after the signal processing and transmission, which assists the doctor in evaluating the treatment effect. The second conductive base 111 has a medicine inlet hole 113 at the bottom, which can effectively solve the problem of small microneedle drug dosage and cannot continuously give medicine.

[0067] In this specification, "one embodiment", "another embodiment", "embodiment", "preferred embodiment" and the like refer to the specific features, structures or characteristics described in connection with the example contained in at least one embodiment described in the general description. The same expression appears in many places in the specification does not necessarily refer to the same embodiment. Further, when a specific feature, structure or characteristic is described in connection with any embodiment, it is claimed that the implementation of this feature, structure or characteristic in connection with other embodiments also falls within the scope of the present application. Although the present application has been described with reference to a plurality of explanatory examples, it should be understood that those skilled in the art can design many other modifications and implementations, which fall within the scope and spirit of the principles disclosed in the present application. More specifically, within the scope of the present application, the subject matter can be modified and improved in terms of the components and / or layout of the layout, and other uses will be apparent to those skilled in the art.

Claims

1. A microneedle real-time imaging and drug delivery system, characterized in that, The micro-needle array disc module is used for releasing drugs into a living body, receiving an external applied excitation electrical signal, and collecting a real-time response electrical signal generated by a tissue in the living body due to excitation by the excitation electrical signal. The excitation power module is used for receiving and providing the excitation electrical signal to the micro-needle array disc module according to an instruction issued by the control module. The signal processing module is used for receiving and pre-processing the real-time response electrical signal collected by the micro-needle array disc module and outputting a pre-processing result. The data transmission module is used for transmitting the secondary processing result output by the control module to the upper computer module. The upper computer module is used for receiving and displaying the result transmitted by the data transmission module, deeply processing the received result, and outputting a deep processing result. The excitation micro-needle unit is used for receiving the excitation electrical signal provided by the excitation power module. The collecting micro-needle unit is used for releasing drugs into a living body and collecting the real-time response electrical signal. The first conductive base is arranged on the first base. The second conductive base is arranged on the second base. The second conductive base and the second base are integrally cast formed, and surfaces of the second conductive base and the second base are covered with metal layers.

2. The micro-needle real-time imaging and drug delivery system according to claim 1, wherein: The excitation micro-needle unit is two, and the collecting micro-needle unit is one or more. The two excitation micro-needle units and the one or more collecting micro-needle units are distributed on a front surface of the micro-needle array disc module.

3. The micro-needle real-time imaging and drug delivery system according to claim 2, wherein: The signal processing module is used for pre-processing the received real-time response electrical signal by using a combination of an amplification chip and a first-order high / low-pass passive filter network, and delivering the pre-processing result to the control module. The signal processing module is one or more, and one signal processing module is connected to one collecting micro-needle unit.

4. The micro-needle real-time imaging and drug delivery system according to claim 3, wherein: The control module adopts the joint processing of a first-order subtractor, a post-stage voltage amplification circuit and an analog-to-digital converter, and sequentially processes the preprocessing result delivered by the signal processing module through the first-order subtractor, the post-stage voltage amplification circuit and the analog-to-digital converter for secondary processing, and delivers the secondary processing result to the data transmission module.

5. The microneedle real-time imaging and drug delivery system of claim 1, wherein, The data transmission module adopts a wireless transmission mode.

6. The microneedle real-time imaging and administration system of claim 1, wherein, The signal processing module, the excitation power supply module, the control module and the data transmission module are all integrated on the back of the microneedle array disc module.

7. The real-time imaging and drug delivery system of claim 1, wherein, Further comprising: A server module for receiving and storing the deep processing result output by the host computer module, and connected with the data transmission module.

Images