Sunscreen composition comprising metal oxide, SPF active ingredient, and one or more SPF enhancing components comprising light stabilizer, antioxidant, or combination thereof

Abstract

The present disclosure relates to broad spectrum sunscreen compositions and to methods of using broad spectrum sunscreen compositions to protect skin from UV radiation. In at least one aspect, the sunscreen comprises a metal oxide (e.g., zinc oxide), one or more SPF active ingredients (e.g., oxime ester and / or octyl salicylate), and one or more SPF enhancing ingredients (e.g., light stabilizers (e.g., butyl octyl salicylate and / or ethylhexylmethoxypolyacrylonitrile) and / or antioxidants (e.g., zinc oxide). ) (e.g., a botanical extract) (e.g., a pongamia pinnata extract)).

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of priority to U.S. Provisional Application No. 63 / 342,394, filed on May 16, 2022, entitled “Sunscreen Compositions and Methods of Use,” the contents of which are incorporated herein in their entirety for all purposes. Technical Field

[0003] The present disclosure relates to broad spectrum sunscreen compositions, and to methods of using broad spectrum sunscreen compositions to protect skin from UV radiation. Background Art

[0004] The negative effects of exposure to ultraviolet ("UV") light are well known. Long-term exposure to sunlight can cause damage to the skin and hair, such as sunburn. Exposure to UV light of certain wavelengths (e.g., about 290 nm to about 400 nm), for example, can cause long-term damage and serious conditions, such as skin cancer.

[0005] For example, ultraviolet radiation in the shorter wavelength UVB region of 290nm to 320nm is considered to be significant in causing burning. Therefore, protection against UVB radiation is traditionally the main target of sunscreen preparations. Relatively recently, further protection against UVA radiation is also desired to reduce long-term skin deterioration. Usually, UV light promotes aging by causing free radicals in the skin, such as the formation of O-, OH, superoxide anions, nitric oxide and hydrogen radicals. Free radicals attack DNA, membrane lipids and proteins to produce carbon free radicals. These then react with oxygen to produce hydroperoxy radicals, which can attack adjacent fatty acids to produce new carbon free radicals. The final result is the loss of skin elasticity and the appearance of wrinkles.

[0006] More importantly, both UVA and UVB wavelengths have been identified as potential factors that increase skin cancers such as melanoma. Skin cancer is one of the most common types of cancer and has a problematic incidence in the United States. For these and other reasons, continued use of surface sunscreens is now highly recommended and common.

[0007] In order to be considered "broad spectrum", sunscreens are subject to strict regulatory approval by various federal agencies. For example, in order to be considered a "broad spectrum" sunscreen, the current federal standard (21 C.FR201.327) requires that the average critical wavelength must be 370nm or greater. The critical wavelength is determined to be the wavelength at which the integral of the spectral absorbance curve reaches 90% of the integral of the UV spectrum from 290nm to 400nm. In addition to this requirement, there are regulatory proposals requiring "broad spectrum" sunscreens to meet a UVAI / UV ratio requirement of greater than or equal to 0.70. Therefore, the demand for broad spectrum sunscreens that can provide adequate protection from UV light and also meet the ever-changing regulatory standards remains unmet. Summary of the invention

[0008] The present disclosure provides new sunscreens that are believed to unexpectedly provide a UVAI / UV ratio requirement of greater than or equal to 0.70 while simultaneously maintaining a sun protection factor (SPF) of 40 and above.

[0009] It is difficult to obtain a desired UVAI / UV ratio while maintaining a relatively high SPF (e.g., ≥40) because increasing or maintaining a high SPF increases or maintains a large denominator, which results in a lower UVAI / UV ratio. The formula for obtaining the UVAI / UV ratio is as follows:

[0010] UVAI / UV=average absorbance 340nm to 400nm / average absorbance UVB (290nm to 320nm) + UVAII (320nm to 340nm) + UVAI (340nm to 400nm). In view of the above formula for obtaining the UVAI / UV ratio, the skilled person will likely recognize that reducing the UVB accessible range will increase the ratio, for example, by reducing the UVB accessible range, which simultaneously reduces the denominator of the above formula and thus increases the overall ratio. However, about 90% of erythema caused by sunlight is caused by wavelengths in the range of 290nm to 320nm (UVB). In addition, since SPF is a measure of the ability of a sunscreen to reduce erythema, it is an effective measure of the ability of a product to block UVB light (290nm to 320nm). Therefore, one of the simplest and most direct ways to increase the UVAI / UV ratio is to reduce the UVB accessible range, which will have the undesirable effect of simultaneously reducing the SPF value of the sunscreen.

[0011] The sunscreen compositions of the present disclosure unexpectedly achieve both a UVAI / UV ratio of greater than or equal to 0.70 and an SPF value of 40 and greater. In addition, the disclosed sunscreen compositions can have a UVAI / UV ratio of greater than or equal to 0.70 and an SPF value of 40 or greater, while achieving commercially desirable aesthetics. Therefore, in one aspect, the sunscreen compositions described herein comprise a metal oxide (e.g., zinc oxide), one or more SPF active ingredients (e.g., octinoxate and / or octisalate), and one or more SPF enhancing ingredients (e.g., photostabilizers (e.g., butyl octyl salicylate and / or ethylhexylmethoxycrylene) and / or antioxidants (e.g., plant extracts) (e.g., Pongamia chinensis extract). In another aspect, the resulting sunscreen comprises a metal oxide (e.g., zinc oxide), one or more SPF active ingredients (e.g., octinoxate and / or octylsalicylate), and one or more SPF enhancing ingredients (e.g., photostabilizers (e.g., butyl octylsalicylate and / or ethylhexyl methoxypolyacrylonitrile) and / or antioxidants (e.g., plant extracts) (e.g., Pongamia chinensis extract)), and has a UVAI / UV ratio requirement of greater than or equal to 0.70 (e.g., 0.7 to 0.8) and an SPF of 40 and above. DETAILED DESCRIPTION

[0012] The following description of the preferred embodiment(s) is merely exemplary in nature and is in no way intended to limit the present disclosure, its application, or uses.

[0013] As used throughout, ranges are used as shorthand for describing individual values ​​and each value within the range. Any value within a range can be selected as the endpoint of the range. In addition, all references cited herein are hereby incorporated by reference in their entirety. In the event that a definition in the present disclosure conflicts with a definition in the cited reference, the present disclosure shall prevail.

[0014] Unless otherwise specified, all percentages and amounts expressed herein and elsewhere in this specification should be understood to refer to the weight percentages of the entire composition. Unless otherwise specified, the amounts given are based on the active weight of the material.

[0015] In one aspect, the present disclosure provides a sunscreen composition (e.g., Composition 1.0), wherein the sunscreen composition comprises:

[0016] -Metal oxides (such as zinc oxide)

[0017] - one or more SPF active ingredients (e.g. octinoxate and / or octisalate) and

[0018] - one or more SPF enhancing ingredients (e.g., photostabilizers (e.g., butyloctyl salicylate and / or ethylhexylmethoxypolyacrylonitrile) and / or antioxidants (e.g., plant extracts) (e.g., Pongamia chinensis extract); and

[0019] The sunscreen composition has a UVAI / UV ratio greater than or equal to 70 and an SPF greater than or equal to 40.

[0020] For example, a sunscreen composition of the present disclosure may include:

[0021] 1.1 Composition 1.0, wherein the metal oxide is selected from the group consisting of: Ba, Zn, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Re, Os, Ir, and Sn. Non-limiting examples of metal oxides include titanium oxide (amorphous or crystalline in the form of rutile and / or anatase), iron oxide, zinc oxide, zirconium oxide, and cerium oxide. The metal oxide may include treated or untreated metal oxides. The treated metal oxides are typically subjected to one or more surface treatments for chemical, electronic, mechanochemical, and / or mechanical properties with compounds such as amino acids; beeswax; fatty acids; fatty alcohols; anionic surfactants; lecithin; sodium, potassium, zinc, iron, or aluminum salts of fatty acids; metal (titanium or aluminum) alkoxides; polyethylene; silicone; proteins (collagen or elastin); alkanolamines; silicon oxides; metal oxides; sodium hexametaphosphate; aluminum oxide; or glycerol. The average particle size of the metal oxide may be from about 5 nm to about 30 μm. In some cases, the average particle size of the metal oxide can be from about 5nm to about 25μm, from about 10nm to about 10μm, or from about 15nm to about 5μm. In other cases, the average particle size of the metal oxide can be from about 5nm to about 100nm, from about 5nm to about 75nm, or from about 10nm to 50nm. Larger particle sizes can also be useful, such as, for example, from about 1μm to about 25μm, from about 5μm to about 20μm, or from about 10μm to about 15μm. The treated metal oxide can have a coating formed thereon. In certain embodiments, the sunscreen composition can include treated and / or coated metal oxides in an amount of about 0.01% by weight to about 3% by weight, based on the gross weight of the sunscreen composition.For example, based on the total weight of the sunscreen composition, the amount of treated and / or coated metal oxide in the sunscreen composition can be from about 0.01 wt % to about 3 wt %, from about 0.01 wt % to about 2 wt %, from about 0.01 wt % to about 1 wt %, from about 0.01 wt % to about 0.8 wt %, from about 0.01 wt % to about 0.6 wt %, from about 0.01 wt % to about 0.4 wt %, from about 0.01 wt % to about 0.2 wt %, from about 0.01 wt % to about 0.1 wt %; from about 0.05 wt % to about 1 wt %, from about 0.05 wt % to about 0.8 wt %, from about 0.05 wt % to about 0.6 wt %, from about 0.05 wt % to about 0.4 wt %, from about 0.05 wt % to about 0.2 wt %, From about 0.05 wt % to about 0.1 wt %; from about 0.1 wt % to about 1 wt %, from about 0.1 wt % to about 0.8 wt %, from about 0.1 wt % to about 0.6 wt %, from about 0.1 wt % to about 0.4 wt %, from about 0.1 wt % to about 0.2 wt %; from about 0.2 wt % to about 1 wt %, from about 0.2 wt % to about 0.8 wt %, from about 0.2 wt % to about 0.6 wt %, from about 0.2 wt % to about 0.4 wt %; from about 0.5 wt % to about 1 wt %, from about 0.5 wt % to about 0.8 wt %, from about 0.5 wt % to about 0.6 wt %; from about 0.8 wt % to about 1 wt %, from about 0.8 wt % to about 1.5 wt %, from about 0.8 wt % to about 2 wt %, or any range or sub-range thereof. In certain embodiments, the amount of treated and / or coated metal oxide in the sunscreen composition is about 0.01 wt%, about 0.05 wt%, about 0.1 wt%, about 0.15 wt%, about 0.2 wt%, or any range or sub-range thereof, based on the total weight of the sunscreen composition.

[0022] 1.2 Composition 1.1, wherein the metal oxide comprises zinc oxide and / or titanium oxide. The zinc oxide may be selected from treated and / or coated zinc oxide. Additionally or alternatively, the titanium oxide may be selected from treated and / or coated titanium oxide. Examples of treated and / or coated zinc oxide include zinc oxide coated with silica and polymethylhydrogensiloxane, zinc oxide coated with polymethylhydrogensiloxane, zinc oxide coated with a copolymer based on perfluoroalkylethyl and perfluoroalkyl phosphate as a dispersion in cyclopentasiloxane, and zinc oxide coated with silica and polymethylsilsesquioxane. Examples of treated and / or coated titanium oxide include those treated with: silica and alumina; alumina and aluminum stearate; iron oxide and iron stearate; silica, alumina and silicone; sodium hexametaphosphate; octyltrimethoxysilane; alumina and stearic acid; alumina and glycerol; alumina and silicone; and combinations thereof.

[0023] 1.3 Any of compositions 1.0 to 1.2, wherein the metal oxide is present in the composition at about 5 wt % to about 25 wt % or 5 wt % to about 15 wt % (e.g., about 7.5 wt % to about 12 wt %) relative to the total weight of the sunscreen composition. For example, based on the total weight of the sunscreen composition, the metal oxide can be present in the sunscreen composition in the following amounts: from about 5 wt % to about 25 wt %, from about 7 wt % to about 25 wt %, from about 9 wt % to about 25 wt %, from about 11 wt % to about 25 wt %, from about 13 wt % to about 25 wt %, from about 15 wt % to about 25 wt %, from about 18 wt % to about 25 wt %; from about 5 wt % to about 21 wt %, from about 7 wt % to about 21 wt %, from about 9 wt % to about 21 wt %, from about 11 wt % to about 21 wt %, from about 13 wt % to about 21 wt %, from about 15 wt % to about 21 wt %, from about 18 wt % to about 21 wt %; from about 5 wt % to about 18 wt %, from about 7 wt % to about 18 wt %, from about 9 wt % to about 15 wt %, From about 11 wt % to about 18 wt %, from about 13 wt % to about 18 wt %, from about 15 wt % to about 18 wt %; from about 5 wt % to about 15 wt %, from about 7 wt % to about 15 wt %, from about 9 wt % to about 15 wt %, from about 11 wt % to about 15 wt %, from about 13 wt % to about 15 wt %; from about 5 wt % to about 13 wt %, from about 7 wt % to about 13 wt %, from about 9 wt % to about 13 wt %, from about 11 wt % to about 13 wt %; from about 5 wt % to about 11 wt %, from about 7 wt % to about 11 wt %, from about 9 wt % to about 11 wt %; from about 5 wt % to about 9 wt %, from about 7 wt % to about 9 wt %; from about 5 wt % to about 8 wt %, from about 7 wt % to about 8 wt %, from about 5 wt % to about 7 wt %, or any range or subrange thereof.

[0024] 1.4 Composition 1.3, wherein the metal oxide comprises zinc oxide in an amount of 5 wt % to 25 wt % (e.g., about 7.5 wt % to about 12 wt %) (e.g., about 7 wt %) (e.g., about 8 wt %) (e.g., about 9 wt %) (e.g., about 10 wt %) (e.g., about 11 wt %) relative to the total weight of the sunscreen composition.

[0025] 1.5 Any of the preceding compositions, wherein the one or more SPF active ingredients are selected from the group consisting of: octinoxate, octylsalicylate, homosalate, avobenzone, octocrylene, para-aminobenzoic acid (PABA), cinoxate, dihydroxybenzone, menthyl anthranilate, padimate O, ensolizole, sulfisobenzone, triethanolamine salicylate, ecamsule, 4-methylbenzylidene camphor, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, Parsol SLX (INCI Polysilicone-15), Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycinnamate, Ethylhexyl Salicylate, Benzophenone-3, Ethylhexyl Dimethyl PABA, Phenylbenzimidazole Sulfonic Acid, Benzophenone-4, Terphenyl Triazine, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Ethylhexyl Triazone, Methoxypropyl Aminocyclohexenyl Ethoxyethyl Cyano Acetate, phenylene bis-diphenyl triazine, isoamyl p-methoxycinnamate, benzalkonium camphor sulfonic acid, camphor benzalkonium methyl sulfate, diethylamino hydroxybenzoyl hexyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, drometrizole trisiloxane, PEG-25PABA, polyacrylamide methyl benzalkonium camphor, benzophenone-5, benzophenone-8, benzophenone-8, diethylhexyl butamido triazone, and a combination of two or more thereof. The SPF active ingredient may be selected from certain UV filters, such as organic UV filters. Examples of organic UV filters include ethylhexyl triazone, bis-ethylhexyloxyphenol methoxyphenyl triazine, dioctyl butamido triazone, drometrizole trisiloxane, and isoamyl 4-methoxycinnamate.

[0026] 1.6 Composition 1.5, wherein the SPF active ingredient includes orcinolone and / or octinoxate. 1.7 Any of the foregoing compositions, wherein the SPF active ingredient is present in the composition at 1% to 10% by weight relative to the total weight of the sunscreen composition. In some embodiments, the sunscreen composition comprises one or more SPF active ingredients in the following amounts, based on the total weight of the sunscreen composition: from about 1% to about 10% by weight, from about 1% to about 8% by weight, from about 1% to about 6% by weight, from about 1% to about 5% by weight, from about 1% to about 4% by weight, from about 1% to about 3% by weight, from about 1% to about 2% by weight; from about 2% to about 10% by weight, from about 2% to about 8% by weight, from about 2% to about 6% by weight, from about 2% to about 5% by weight, from about 2% to about 4% by weight , about 2 weight % to about 3 weight %; about 3 weight % to about 10 weight %, about 3 weight % to about 8 weight %, about 3 weight % to about 6 weight %, about 3 weight % to about 5 weight %, about 3 weight % to about 4 weight %; about 4 weight % to about 10 weight %, about 4 weight % to about 8 weight %, about 4 weight % to about 6 weight %, about 4 weight % to about 5 weight %; about 5 weight % to about 10 weight %, about 5 weight % to about 8 weight %, about 5 weight % to about 6 weight %; about 7 weight % to about 10 weight %, about 7 weight % to about 8 weight %, or any range or sub-range thereof.

[0027] 1.8 Any of the preceding sunscreen compositions, wherein the one or more SPF enhancing ingredients include one or more photostabilizers and / or antioxidants.

[0028] 1.9 Any of the aforementioned sunscreen compositions, wherein the sunscreen composition comprises a photostabilizer selected from the group consisting of ethylhexyl triazone, dioctyl butyramido triazone, benzalmalonate polysiloxane, dibenzoylmethanesulfonate, Azolylphenylethylhexyliminotriazine, drometrizole trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol, bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl octyl salicylate, α-cyanodiphenylacrylate (e.g., ethylhexyl methoxypolyacrylonitrile or 2-ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate), isopentyl 4-methoxycinnamate, diethylhexyl syringylidenemalonate, diethylhexyl 2,6-naphthalene dicarboxylate, octocrylene, and combinations thereof. In some embodiments, the light stabilizer includes dioctyl butyramido triazone, benzalmalonate polysiloxane, butyl octyl salicylate, α-cyanodiphenylacrylate (e.g., ethylhexyl methoxypolyacrylonitrile or 2-ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate), isopentyl 4-methoxycinnamate, diethylhexyl syringylidenemalonate, diethylhexyl 2,6-naphthalene dicarboxylate, octocrylene, or a combination of two or more thereof.

[0029] 1.10 The sunscreen composition of 1.9, wherein the light stabilizer comprises butyl octyl salicylate and / or ethylhexyl methoxy polyacrylonitrile.

[0030] 1.11 Any of the aforementioned sunscreen compositions, wherein the photostabilizer is present in the sunscreen composition in an amount of 0.5 wt % to about 10 wt % (e.g., 1 wt % to 7.5 wt %) (e.g., 2 wt % to 5 wt %) (e.g., about 2 wt %) (e.g., about 3 wt %) (e.g., about 3.5 wt %) (e.g., about 4 wt %) (e.g., about 4.5 wt %) (e.g., about 5 wt %) relative to the total weight of the sunscreen composition. For example, based on the total weight of the sunscreen composition, the sunscreen composition may include the photostabilizer in the following amounts: from about 0.5 wt % to about 10 wt %, from about 0.5 wt % to about 8 wt %, from about 0.5 wt % to about 6 wt %, from about 0.5 wt % to about 5 wt %, from about 0.5 wt % to about 4 wt %, from about 0.5 wt % to about 3 wt %, from about 0.5 wt % to about 2 wt %; from about 1 wt % to about 10 wt %, from about 1 wt % to about 8 wt %, from about 1 wt % to about 6 wt %, from about 1 wt % to about 5 wt %, from about 1 wt % to about 4 wt %, from about 1 wt % to about 3 wt %, from about 1 wt % to about 2 wt %; % to about 8 weight %, about 2 weight % to about 6 weight %, about 2 weight % to about 5 weight %, about 2 weight % to about 4 weight %, about 2 weight % to about 3 weight %; about 3 weight % to about 10 weight %, about 3 weight % to about 8 weight %, about 3 weight % to about 6 weight %, about 3 weight % to about 5 weight %, about 3 weight % to about 4 weight %; about 4 weight % to about 10 weight %, about 4 weight % to about 8 weight %, about 4 weight % to about 6 weight %, about 4 weight % to about 5 weight %; about 5 weight % to about 10 weight %, about 5 weight % to about 8 weight %, about 5 weight % to about 6 weight %; about 7 weight % to about 10 weight %, about 7 weight % to about 8 weight %, or any range or sub-range thereof.

[0031] 1.12 Any of the foregoing sunscreen compositions, wherein the photostabilizer comprises from about 0.5% to about 10% by weight of butyl octyl salicylate (e.g., 1% to 7.5% by weight) (e.g., 2% to 5% by weight) (e.g., about 2% by weight) (e.g., about 3% by weight) (e.g., about 3.5% by weight) (e.g., about 4% by weight) (e.g., about 4.5% by weight) (e.g., about 5% by weight), relative to the total weight of the sunscreen composition. In some embodiments, butyl octyl salicylate is present in the sunscreen composition in any of the amounts listed above with respect to the photostabilizer.

[0032] 1.13 Any of the foregoing sunscreen compositions, wherein the light stabilizer comprises from about 0.5 wt % to about 10 wt % of ethylhexylmethoxypolyacrylonitrile (e.g., 1 wt % to 7.5 wt %) (e.g., 2 wt % to 5 wt %) (e.g., about 2 wt %) (e.g., about 3 wt %) (e.g., about 3.5 wt %) (e.g., about 4 wt %) (e.g., about 4.5 wt %) (e.g., about 5 wt %), relative to the total weight of the sunscreen composition. In some embodiments, the ethylhexylmethoxypolyacrylonitrile is present in the sunscreen composition in any of the amounts listed above with respect to the light stabilizer.

[0033] 1.14 Any of the preceding sunscreen compositions wherein the SPF enhancing ingredient comprises an antioxidant.

[0034] 1.15 The sunscreen composition of 1.14, wherein the antioxidant is selected from Angelica archangelica, Arnica montana, Camellia sinensis, Cupressus semper, Coffee arabica, Polygonatum multiflorum, Pongamia pinnata extract, Rosmarinus officinalis, Evernia fufuracea, Evernia prunastri, Aventa sativa, vitamin A, vitamin E, peptides, flavonoids, flavonols, and combinations of two or more thereof.

[0035] 1.16 Any of the aforementioned sunscreen compositions, such as the sunscreen composition of 1.15, wherein the antioxidant is present in an amount of about 0.1 wt % to about 5 wt % (e.g., 0.1 wt % to 1 wt %) (e.g., 0.1 wt % to 0.5 wt %) (e.g., about 0.1 wt %) (e.g., about 0.2 wt %) (e.g., about 0.25 wt %) (e.g., about 0.3 wt %) (e.g., about 0.4 wt %) (e.g., about 0.5 wt %) relative to the total weight of the sunscreen composition. In some cases, the sunscreen composition includes one or more antioxidants in an amount of about 0.1 wt % to about 5 wt %, about 0.1 wt % to about 4 wt %, about 0.1 wt % to about 3 wt %, about 0.1 wt % to about 2 wt %, about 0.1 wt % to about 1 wt %; about 0.5 wt % to about 5 wt %, about 0.5 wt % to about 4 wt %, about 0.5 wt % to about 3 wt %, about 0.5 wt % to about 2 wt %, about 0.5 wt % to about 1 wt %; about 1 wt % to about 5 wt %, about 1 wt % to about 4 wt %, about 1 wt % to about 3 wt %, about 1 wt % to about 2 wt %; about 2 wt % to about 5 wt %, about 2 wt % to about 4 wt %, about 2 wt % to about 3 wt %; about 3 wt % to about 5 wt %, about 3 wt % to about 4 wt %, about 4 wt % to about 5 wt %, or any range or sub-range thereof, based on the total weight of the sunscreen composition. In certain embodiments, the total amount of antioxidants in the oral care composition can be from about 0.01 wt % to about 1 wt %, from about 0.01 wt % to about 0.8 wt %, from about 0.01 wt % to about 0.5 wt %, from about 0.01 wt % to about 0.3 wt %, from about 0.01 wt % to about 0.2 wt %, from about 0.01 wt % to about 0.1 wt %; from about 0.05 wt % to about 1 wt %, from about 0.05 ... From about 0.05 wt % to about 0.5 wt %, from about 0.05 wt % to about 0.3 wt %, from about 0.05 wt % to about 0.2 wt %, from about 0.05 wt % to about 0.1 wt %; from about 0.1 wt % to about 1 wt %, from about 0.1 wt % to about 0.8 wt %, from about 0.1 wt % to about 0.5 wt %, from about 0.1 wt % to about 0.3 wt %, from about 0.1 wt % to about 0.2 wt %, from about 0.1 wt % to about 0.1 wt %, or any range or sub-range thereof.

[0036] 1.17 The sunscreen composition of 1.15 or 1.16, wherein the antioxidant comprises a Pongamia glabra extract, and wherein the Pongamia glabra extract is selected from the group consisting of: Pongamia glabra root extract, Pongamia glabra seed oil, Pongamia glabra seed oil C16-24 isoalkyl esters, Pongamia glabra fruit extract, Pongamia glabra leaf extract, and Pongamia glabra seed extract.

[0037] 1.18 The sunscreen composition of 1.17, wherein the Pongamia cordata extract is a Pongamia cordata seed extract, and wherein the Pongamia cordata seed extract is present in an amount of about 0.01 wt % to about 5 wt % or about 0.1 wt % to about 5 wt % (e.g., about 0.01 wt % to 1 wt %) (e.g., about 0.05 wt % to about 0.5 wt %) (e.g., about 0.05 wt % to about 0.2 wt %) (e.g., about 0.05 wt % to about 0.1 wt %) (e.g., about 0.2 wt %) (e.g., about 0.25 wt %) (e.g., about 0.3 wt %) (e.g., about 0.4 wt %) (e.g., about 0.5 wt %) relative to the total weight of the sunscreen composition. For example, based on the total weight of the sunscreen composition, the sunscreen composition may include the Pongamia chinensis extract in the following amounts: about 0.01 wt % to about 1 wt %, about 0.01 wt % to about 0.8 wt %, about 0.01 wt % to about 0.5 wt %, about 0.01 wt % to about 0.3 wt %, about 0.01 wt % to about 0.2 wt %, about 0.01 wt % to about 0.1 wt %; about 0.05 wt % to about 1 wt %, about 0.05 wt % to about 0.8 wt %, about % to about 0.1 wt %; about 0.1 wt % to about 1 wt %, about 0.1 wt % to about 0.8 wt %, about 0.1 wt % to about 0.5 wt %, about 0.1 wt % to about 0.3 wt %, about 0.1 wt % to about 0.2 wt %, about 0.1 wt % to about 0.1 wt %, or any range or sub-range thereof. In some embodiments, the Pongamia chinensis seed extract is present in the sunscreen composition in any of the amounts listed above relative to the antioxidant.

[0038] 1.19 A sunscreen composition according to any of the preceding sunscreen compositions, wherein the sunscreen composition comprises:

[0039] Zinc oxide;

[0040] Ocrinol and / or octinoxate; and

[0041] Butylhexyl salicylate, ethylhexyl methoxypolyacrylonitrile, Pongamia chinensis extract,

[0042] The UVAI / UV ratio of the sunscreen is greater than or equal to 70, and the SPF is greater than or equal to 40.

[0043] 1.20 A sunscreen composition according to any of the preceding sunscreen compositions, wherein the sunscreen composition comprises:

[0044] Zinc oxide in an amount of 5 wt % to 15 wt % (e.g., about 9 wt %) (e.g., about 11 wt %);

[0045] Octyl salicylate in an amount of 1 wt % to 10 wt % (e.g., about 4 wt %);

[0046] Butyl octyl salicylate in an amount of 0.5 wt % to 5 wt % (e.g., about 2 wt %);

[0047] Ethylhexylmethoxypolyacrylonitrile in an amount of 0.5 wt % to 5 wt % (e.g., about 2 wt %);

[0048] Pongamia chinensis extract in an amount of 0.1 wt % to 1 wt % (e.g., about 0.25 wt %); and

[0049] wherein the UVAI / UV ratio of the sunscreen agent is greater than or equal to 70, and the SPF is greater than or equal to 40, and wherein all weight percentages are based on the total weight of the sunscreen composition.

[0050] 1.21 A composition of any of the preceding sunscreen compositions, wherein the sunscreen composition comprises:

[0051] Zinc oxide in an amount of about 5 wt % to about 15 wt % (e.g., about 9 wt %) (e.g., about 11 wt %);

[0052] Octyl salicylate in an amount from about 1 wt % to about 10 wt % (e.g., about 4 wt %);

[0053] Butyl octyl salicylate in an amount from about 0.5 wt % to about 5 wt % (e.g., about 2 wt %);

[0054] ethylhexylmethoxypolyacrylonitrile in an amount from about 0.5 wt % to about 5 wt % (e.g., about 2 wt %);

[0055] Pongamia chinensis extract in an amount of about 0.1 wt % to about 1 wt % (e.g., about 0.25 wt %); and

[0056] Optionally, titanium dioxide in an amount of about 0.1 wt % to 2 wt % (e.g., about 1 wt %),

[0057] wherein the UVAI / UV ratio of the sunscreen agent is greater than or equal to 70, and the SPF is greater than or equal to 40, and wherein all weight percentages are based on the total weight of the sunscreen composition.

[0058] 1.22 A composition of any of the preceding sunscreen compositions, wherein the sunscreen composition comprises:

[0059] Zinc oxide in an amount of about 5 wt % to about 15 wt % (e.g., about 9 wt %) (e.g., about 11 wt %);

[0060] Ocrinol ester in an amount of about 1 wt % to about 10 wt % (e.g., about 2 wt %) (e.g., about 3.5 wt %) (e.g., about 4 wt %);

[0061] Butyl octyl salicylate in an amount from about 0.5 wt % to about 5 wt % (e.g., about 2 wt %);

[0062] Ethylhexylmethoxypolyacrylonitrile in an amount from about 0.5 wt % to about 5 wt % (e.g., about 2 wt %); and

[0063] Pongamia chinensis extract in an amount of 0.1 wt % to 1 wt % (e.g., about 0.25 wt %),

[0064] wherein the UVAI / UV ratio of the sunscreen agent is greater than or equal to 70, and the SPF is greater than or equal to 40, and wherein all weight percentages are based on the total weight of the sunscreen composition.

[0065] 1.23. Any of the foregoing sunscreen compositions, wherein the sunscreen composition further comprises water (e.g., 50% to 70% by weight) (e.g., about 62% by weight). Based on the total weight of the sunscreen composition, the sunscreen composition may comprise water in the following amounts: from about 50% to about 70% by weight, from about 50% to about 67% by weight, from about 50% to about 64% by weight, from about 50% to about 62% by weight, from about 50% to about 60% by weight, from about 50% to about 57% by weight; from about 53% to about 70% by weight, from about 53% to about 67% by weight, from about 53% to about 64% by weight, from about 53% to about 62% by weight, from about 53% to about 60% by weight, from about 53% to about 57% by weight; from about 56% to about 70% by weight % to about 67 weight %, about 56 weight % to about 64 weight %, about 56 weight % to about 62 weight %, about 56 weight % to about 60 weight %; about 59 weight % to about 70 weight %, about 59 weight % to about 67 weight %, about 59 weight % to about 64 weight %, about 59 weight % to about 62 weight %; about 61 weight % to about 70 weight %, about 61 weight % to about 67 weight %, about 61 weight % to about 64 weight %, about 61 weight % to about 62 weight %; about 63 weight % to about 70 weight %, about 63 weight % to about 67 weight %, or any range or sub-range thereof.

[0066] 1.24 Any of the preceding sunscreen compositions, wherein the sunscreen composition is in the form of a cream, gel, paste, lotion, rinse, foam, emulsion, spray, and combinations thereof.

[0067] 1.25 Any of the preceding sunscreen compositions for use in a cosmetic, dermatological, pharmaceutical or medical composition.

[0068] 1.26 Any of the preceding sunscreen compositions wherein the composition is topically applied.

[0069] 1.27 Any of the aforementioned sunscreen compositions, further comprising one or more ingredients selected from the group consisting of tanning agents, free radical scavengers, vitamins, enzymes, herbal ingredients, polymers, antioxidants, omega-3 / 6 fatty acids, and combinations of two or more thereof.

[0070] 1.28 Any of the preceding skin care compositions, wherein the sunscreen composition comprises an additional active ingredient selected from the group consisting of carnosine, cica (asiaticoside), vitamin E (e.g., α-tocopherol, γ-tocopherol, β-tocopherol, δ-tocopherol, and combinations thereof), hyaluronic acid and its salts (e.g., sodium hyaluronate), magnesium sulfate, saccharide isomerates, ketocarotenoids (e.g., astaxanthin), bisabolol, vitamin B (e.g., niacinamide), nicotinamide adenine dinucleotide (NAD), ginger extract, and combinations of two or more thereof.

[0071] 1.29 Any of the preceding sunscreen compositions, wherein the sunscreen composition comprises:

[0072] - from about 5% to about 25% by weight of metal oxide (e.g., from 7% to 13% by weight), relative to the total weight of the sunscreen composition;

[0073] - One or more SPF active ingredients selected from octinoxate, octylsalicylate, homosalate, avobenzone, octocrylene, p-aminobenzoic acid, cinoxate, dioxybenzone, menthyl anthranilate, padimate O, ensolizole, sulfisobenzone, triethanolamine salicylate, ecamsule, 4-methylbenzylidene camphor, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, Parsol SLX (INCI Polysilicone-15), Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycinnamate, Ethylhexyl Salicylate, Benzophenone-3, Ethylhexyl Dimethyl PABA, Phenylbenzimidazole Sulfonic Acid, Benzophenone-4, Terphenyl Triazine, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Ethylhexyl Triazone, Methoxypropyl Aminocyclohexenyl Ethoxyethyl cyanoacetate, phenylene bis-diphenyl triazine, isoamyl p-methoxycinnamate, benzalkonium camphorsulfonic acid, camphor benzalkonium methylsulfate, diethylamino hydroxybenzoyl hexyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, drometrizole trisiloxane, PEG-25PABA, polyacrylamidomethylbenzylidene camphor, benzophenone-5, benzophenone-8, diethylhexyl butamido triazone, and combinations of two or more thereof.

[0074] - one or more SPF enhancing ingredients including photostabilizers and / or antioxidants,

[0075] The light stabilizer is selected from the group consisting of ethylhexyl triazone, dioctyl butyramido triazone, benzalmalonate polysiloxane, dibenzoylmethane azolylphenylethylhexyliminotriazine, drometrizole trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol and bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl octyl salicylate, α-cyanodiphenylacrylate (e.g., ethylhexyl methoxypolyacrylonitrile or 2-ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate), isopentyl 4-methoxycinnamate, and combinations thereof; and

[0076] The UVAI / UV ratio of the sunscreen is greater than or equal to 70, and the SPF is greater than or equal to 40.

[0077] 1.30 Any of the foregoing sunscreen compositions, wherein the sunscreen composition has a UVAI / UV ratio of greater than or equal to 70. In certain embodiments, the sunscreen composition has a UVAI / UV ratio of about 72 or greater, about 74 or greater, about 76 or greater, about 78 or greater, about 80 or greater, or about 82 or greater. Additionally or alternatively, the sunscreen composition has an SPF value of 40.3 or greater. For example, the sunscreen composition may have an SPF of about 42 or greater, about 45 or greater, about 48 or greater, about 50 or greater, about 52 or greater, about 55 or greater, about 58 or greater, about 60 or greater, about 62 or greater, about 65 or greater, about 68 or greater, about 70 or greater, about 72 or greater, about 75 or greater, about 78 or greater, or about 80 or greater.

[0078] In another aspect, the present disclosure also includes a method of increasing the SPF of a sunscreen composition (e.g., method 2.0), wherein the method includes adding one or more SPF enhancing ingredients to the sunscreen composition (e.g., any of compositions 1.0 et seq.).

[0079] For example, according to one aspect of the present disclosure, a method is provided, the method comprising:

[0080] 2.1 Method 2.0, wherein the method comprises formulating a sunscreen composition having one or more SPF enhancing ingredients selected from: photostabilizers (e.g., butyl octyl salicylate and / or ethylhexyl methoxy polyacrylonitrile), antioxidants (e.g., plant extracts) (e.g., Pongamia chinensis extract), and combinations of two or more thereof.

[0081] 2.2 Method 2.0 or 2.1, wherein the SPF enhancing ingredient is selected from the group consisting of butyloctyl salicylate, ethylhexyl methoxypolyacrylonitrile, Pongamia serrata extract, and combinations thereof.

[0082] 2.3 Any of methods 2.0 to 2.2, wherein the resulting sunscreen composition has a UVAI / UV ratio greater than or equal to 70.

[0083] 2.4 Any of the preceding methods, wherein the SPF is greater than or equal to 40.

[0084] 2.5 Any of the preceding methods, wherein the UVAI / UV ratio is greater than or equal to 70, and the SPF is greater than or equal to 40.

[0085] 2.6 Any of the preceding methods, wherein the sunscreen composition is any of composition 1.0 et seq.

[0086] As used herein, the ultraviolet ("UV" herein) region of the electromagnetic spectrum includes three bands, designated as UVA from 320nm to 400nm, UVB from 290nm to 320nm, and UVC from 200nm to 290nm. The UVA band can be further divided into UVAII from 315nm to 340nm and UVAI from 340nm to 400nm. The visible portion of the spectrum is generally about 400nm to about 700nm.

[0087] As used herein, the term "active ingredient" generally refers to the ingredient in a sunscreen composition that is primarily responsible for absorbing UV radiation.

[0088] As used herein, the term "inactive ingredients" is used herein to refer to ingredients in the sunscreen composition that do not substantially absorb UV radiation, and may include emulsifiers, emollients, preservatives, fragrances, dyes, antioxidants, chelating agents and the like.

[0089] As used herein, "sunscreen composition" refers to a formulation (e.g., a lotion, spray, gel, or other topical product) that absorbs and / or reflects a portion of the sun's ultraviolet (UV) radiation and thereby helps protect against the negative effects of sun exposure, such as sunburn, premature aging, etc.

[0090] As used herein, "topically applying" or "topical application" or "topically applied" means spraying, wiping, spreading, or applying directly to the external skin or scalp, such as by using the hands or an applicator such as a wipe, roller, or spray.

[0091] As used herein, UV radiation is divided into three bands: UVA, UVB, and UVC. All three bands are classified as possible human carcinogens. "UVA" refers to long wavelength. UVA covers the range of 315nm to 400nm. As used herein, UVA light wavelengths are divided into UVA-I (340nm to 400nm) and UVA-II (315nm to 340nm).

[0092] As used herein, UVB refers to mid-wavelength. UVB covers the range of 280nm to 315nm.

[0093] As used herein, "Pongamia odorata seed extract" may be used interchangeably with "Pongamia dione," which is the chemical name for Pongamia odorata seed extract.

[0094] In certain aspects, the compositions of the present disclosure, such as any of Compositions 1.0 et seq., can include a cosmetically acceptable carrier. The phrase "cosmetically acceptable" means that the material is compatible with the skin and hair. For example, "cosmetically acceptable carrier" means a carrier that is compatible with the skin and hair and is acceptable for application to the body.

[0095] The acceptable carrier of cosmetics can include, for example, water and / or a water-soluble solvent. Non-limiting examples of the acceptable carrier of cosmetics include glycerol, C1-4 alcohol, organic solvent, fatty alcohol, fatty ether, fatty ester, polyol, glycol, vegetable oil, mineral oil, liposome, lamellar lipid material, water or any combination thereof.

[0096] As examples of organic solvents, non-limiting mention may include: monohydric alcohols and polyhydric alcohols, such as ethanol, isopropanol, propanol, benzyl alcohol and phenylethyl alcohol; or glycols or glycol ethers, such as monomethyl ether, monoethyl ether and monobutyl ether of ethylene glycol and propylene glycol, or ethers thereof, such as monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol; and alkyl ethers of diethylene glycol, such as monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propanediol and glycerol. The organic solvent can be a volatile or non-volatile compound.

[0097] In some cases, the cosmetically acceptable carrier may include water, a mixture of water and at least one cosmetically acceptable organic solvent, or at least one cosmetically acceptable organic solvent. In addition, the cosmetically acceptable carrier may be or may include ethanol, glycol ethers such as dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentylene glycol, hexylene glycol, glycerol, and mixtures thereof.

[0098] The total amount of cosmetically acceptable carrier can vary, but in some cases, can be from about 50% to about 95% by weight, based on the total weight of the sunscreen composition. In some cases, the total amount of cosmetically acceptable carrier is from 55% to 95%, from 60% to 95%, from 70% to 95%, from 75% to 95%, from 50% to 90%, from 60% to 90%, from 70% to 90%, or from about 75% to about 90% by weight, based on the total weight of the sunscreen composition.

[0099] In certain aspects, the composition of the present disclosure, such as any of composition 1.0 et seq., etc., may contain one or more organic solvents. For example, the organic solvent may be selected from any of the following: monohydric alcohols and polyhydric alcohols, such as ethanol, isopropanol, propanol, benzyl alcohol and phenylethyl alcohol; or glycols or glycol ethers, such as monomethyl ether, monoethyl ether and monobutyl ether of ethylene glycol and propylene glycol, or ethers thereof, such as monomethyl ether of propylene glycol, butanediol, hexanediol, dipropylene glycol; and alkyl ethers of diethylene glycol, such as monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butanediol, hexanediol, propanediol, glycerol and combinations thereof. The organic solvent may be a volatile or non-volatile compound.

[0100] In some aspects, the organic solvent can be selected from ethanol, glycol ethers such as dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentylene glycol, hexylene glycol, glycerol, and mixtures of two or more thereof.

[0101] In certain aspects, the compositions of the present disclosure, such as any of compositions 1.0 et seq., etc., may include one or more oils and / or emollients. For example, the oil / emollient that may be included in the sunscreen compositions of the present disclosure may be selected from any of the following: hydrocarbon-based oils of plant origin, such as liquid triglycerides of fatty acids containing 4 to 10 carbon atoms, such as heptanoic or caprylic triglycerides, or alternatively, such as sunflower oil, corn oil, soybean oil, marrow oil, grapeseed oil, sesame seed oil, hazelnut oil, apricot oil, macadamia oil, arara oil, coriander oil, castor oil, avocado oil, caprylic / capric triglycerides, jojoba oil, shea butter, and caprylyl glycol; synthetic esters and ethers of fatty acids, such as purcellin oil; oil), octyldodecyl neopentanoate, 2-octyldodecyl stearate, 2-octyldodecyl erucate, isostearyl isostearate; hydroxylated esters, for example isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, glyceryl behenate, diisostearyl malate or triisocetyl citrate; fatty alcohol heptanoates, caprylates or caprates; polyol esters, for example propylene glycol dicaprylate, neopentyl glycol diheptanoate and diethylene glycol diisononanoate; and pentaerythritol esters, for example pentaerythritol tetraisostearate or isopropyl lauroyl sarcosinate; linear or branched hydrocarbons of mineral or synthetic origin, for example volatile or non-volatile liquid paraffins and their derivatives, petroleum jelly, polydecene, isohexadecane, isododecane, hydrogenated polyisobutenes such as Parleam oil, or n-undecane (C 11 ) and n-tridecane (C 13); fluorinated oils partly based on hydrocarbons and / or on silicones, such as those described in document JP-A-2 295 912; silicone oils, such as volatile or non-volatile polymethylsiloxanes (PDMS) with linear or cyclic silicone chains, which are liquid or pasty at room temperature, in particular volatile silicone oils, especially cyclomethicones (cyclomethicones), such as cyclohexadimethicone and cyclopentadimethicone; polydimethylsiloxanes containing alkyl, alkoxy or phenyl groups which are side groups of the silicone chain or are at the end of the silicone chain, these groups containing 2 to 24 carbon atoms; phenyl silicones, such as phenyl trimethicone, phenyl dimethicone, phenyl trimethylsiloxydiphenylsiloxane, diphenyl dimethicone, diphenylmethyldiphenyl trisiloxane or 2-phenylethyl trimethylsiloxysilicate, polymethylphenylsiloxane; PEG-20 methyl glucose sesquistearate and mixtures thereof.

[0102] In other aspects, additional specific examples of oils / emollients in the compositions of the present disclosure (e.g., any of Compositions 1.0 et seq.) can be selected from: cocoyl glycerides, cyclomethicone, dimethicone, dioctyl maleate, caprylic / capric triglyceride, isopropyl myristate, octyl stearate, isostearyl linoleate, lanolin oil, coconut oil, cocoa butter, olive oil, avocado oil, aloe extract, jojoba oil, castor oil, fatty acids, oleic acid, stearic acid, fatty alcohols, cetyl alcohol, hexadecyl alcohol, diisopropyl adipate, hydroxybenzoates, C9-C 15 Alcohol benzoate, isononyl isononanoate, alkane, mineral oil, silicone, dimethyl polysiloxane, ether, polyoxypropylene butyl ether, polyoxypropylene cetyl ether, benzoic acid C 12 -C 15 Alkyl esters, aryl alkyl benzoates, isopropyl lauroyl sarcosinate, and any combination thereof.

[0103] In other aspects, any sunscreen composition of the present disclosure (e.g., any of Compositions 1.0 et seq.) may include oily esters, ethers, and aloe extracts, and mixtures thereof. For example, emollients that may be included in the sunscreen composition include: dicaprylyl ether (Cetiol OE), Lexol IPL, octyl palmitate, isopropyl palmitate, neopentyl glycol heptanoate, neopentyl glycol diheptanoate, actiphyte of aloe, Trivent NP-13, and C benzoate. 12-15 Alkyl esters.

[0104] In some aspects, the sunscreen compositions of the present disclosure (e.g., any of compositions 1.0 et seq.) may include one or more conventional cosmetic oils, such as mineral oil; hydrogenated polyisobutene; synthetic or naturally-occurring squalane; cosmetic esters or ethers, which may be branched or unbranched, saturated or unsaturated; vegetable oils; or a mixture of two or more thereof.

[0105] Particularly suitable oils are vegetable oils with a high proportion of ω-3 and ω-6 fatty acids, for example nut oils, such as hazelnut oil. Other vegetable oils can also be used, for example calendula oil, jojoba oil, avocado oil, macadamia oil, castor oil, cocoa butter, coconut oil, corn oil, cottonseed oil, olive oil, palm kernel oil, rapeseed oil, safflower oil, sesame oil, soybean oil, sunflower seed oil, wheat germ oil, grape seed oil, macadamia nut oil, thistle oil and mixtures thereof. These other oils can not achieve the desired direction of action well.

[0106] The total amount of oil and / or emollient (if present) in the sunscreen composition can vary, but can be from about 1 wt % to about 75 wt %, based on the total weight of the sunscreen composition. In some cases, the total amount of oil and / or emollient can be from 1 wt % to 60 wt %, from 1 wt % to 50 wt %, from 1 wt % to 20 wt %, from 5 wt % to 70 wt %, from 5 wt % to 60 wt %, from 5 wt % to 50 wt %, from 10 wt % to 60 wt %, from 10 wt % to 50 wt %, from 25 wt % to 75 wt %, or from 30 wt % to 60 wt %, based on the total weight of the sunscreen composition.

[0107] In certain aspects, the compositions of the present disclosure (e.g., any of compositions 1.0 et seq., etc.) may include one or more film formers to ensure uniform coverage of the UV filter and may be used to waterproof the sunscreen composition. In one aspect, the film former is a hydrophobic substance that imparts film-forming and / or waterproof properties. For example, one such agent is polyethylene with a molecular weight of 400. Another suitable film former is polyethylene with a molecular weight of 2000. However, another suitable film former is a synthetic wax. Other film formers include any one selected from the following: acrylate / acrylamide copolymers, acrylate copolymers, acrylate / methacrylate C 12 -C 22 Alkyl esters copolymer, polyethylene, wax, VP / dimethicone acrylate / polycarbamoyl polyethylene glycol esters, butylated PVP, PVP / hexadecene copolymer, octadecene / MA copolymer, PVP / eicosene copolymer, triacontyl PVP, rapeseed / tung oil copolymer, decamethylcyclopentasiloxane (and) trimethylsiloxysilicate and mixtures thereof.

[0108] In one aspect, the film-forming polymer (e.g., PVP / eicosene copolymer) contained in the sunscreen composition (e.g., any of Compositions 1.0 et seq.) is insoluble in ethanol. For example, a film former used in ethanol-based sunscreen products is Dermacryl LT or Dermacryl 79 (INCI name: Acrylates / Octylacrylamide Copolymer) sold by Akzo Nobel. Dermacryl LT (CAS No.: 80570-62-3) is a hydrophobic, high molecular weight, carboxylated acrylic copolymer. It acts as a film former in a wide range of cosmetic formulations, imparting water resistance, increasing occlusivity, and reducing rub-off of active substances.

[0109] The total amount of film formers (if present) in the sunscreen composition can vary, but in one aspect, can include 0.1 wt % to 40 wt %, based on the total weight of the sunscreen composition. In some aspects, the total amount of film formers can be 0.1 wt % to 30 wt %, 0.1 wt % to 20 wt %, 0.1 wt % to 10 wt %, 1 wt % to 40 wt %, 1 wt % to 30 wt %, 1 wt % to 20 wt %, or 1 wt % to 10 wt %, based on the total weight of the sunscreen composition.

[0110] In certain aspects, the composition of the present disclosure (e.g., any of Composition 1.0 et seq.) may comprise one or more emulsifiers selected from the following: amphoteric emulsifiers, anionic emulsifiers, cationic emulsifiers, or nonionic emulsifiers, used alone or as a mixture, and optionally a co-emulsifier. In one aspect, when the sunscreen composition is in the form of an emulsion, an emulsifier is used. For example, the emulsifier is selected in an appropriate manner according to the emulsion to be obtained (W / O or O / W).

[0111] For W / O emulsions, examples of emulsifiers include: hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, dimethicone copolyols such as a mixture of cyclomethicone and dimethicone copolyol, and alkyl dimethicone copolyols such as lauryl dimethicone copolyol and cetyl dimethicone copolyol. Crosslinked elastomeric solid organopolysiloxanes containing at least one oxyalkylene group (e.g., those obtained according to the process of Examples 3, 4, and 8 of U.S. Pat. No. 5,412,004 and the Examples of U.S. Pat. No. 5,811,487, such as the product of Example 3 (Synthesis Example) of U.S. Pat. No. 5,412,004, the contents of each of which are incorporated herein by reference) can also be used as surfactants for W / O emulsions.

[0112] For O / W emulsions, examples of emulsifiers include any one selected from the following: nonionic emulsifiers, such as oxyalkylenated (e.g., polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acid esters of sorbitan; oxyalkylenated (oxyethylenated and / or oxypropylenated) fatty acid esters; oxyalkylenated (oxyethylenated and / or oxypropylenated) fatty alcohol ethers; sugar esters, such as sucrose stearate; and mixtures thereof.

[0113] The fatty acid esters of sugars that can be used as non-ionic amphiphilic lipids can be selected from the group consisting of: C8-C 22 Esters or mixtures of fatty acids with sucrose, maltose, glucose or fructose, and C 14 -C 22 Esters or mixtures of esters of fatty acids with methyl glucose.

[0114] C8-C 22 or C 14 -C 22 The fatty acid may comprise a saturated or unsaturated linear alkyl chain having 8 to 22 or 14 to 22 carbon atoms, respectively. The fatty unit of the ester may be selected from stearate, behenate (e.g., glyceryl behenate), arachidonate, palmitate (e.g., isopropyl palmitate), myristate, laurate, caprate, and mixtures thereof.

[0115] In some aspects, the ester or ester mixture of fatty acids and sucrose, maltose, glucose or fructose that can be included in any composition of the present disclosure (e.g., any of Compositions 1.0 et seq.) can be selected from: sucrose monostearate; sucrose distearate; sucrose tristearate and mixtures thereof, having an HLB (hydrophile-lipophile balance) of 5, 7, 11 and 16; methyl glucose; distearate of methyl glucose polyglycerol-3; glucose monoesters or maltose monoesters, such as methyl O-hexadecanoyl-6-D-glucoside and O-hexadecanoyl-6-D-maltoside; and combinations thereof.

[0116] In some aspects, the fatty alcohol ether of sugar that can be used in the sunscreen composition (e.g., any of compositions 1.0 et seq.) as the nonionic amphiphilic lipid can be selected from the group consisting of: C8-C 22 Ethers or ether mixtures of fatty alcohols with glucose, maltose, sucrose or fructose, and C 14 -C 22 Ethers or ether mixtures of fatty alcohols and methyl glucose.

[0117] In certain aspects, the C8-C10-10 ether-forming fatty units of the emulsions that can be used in the sunscreen composition (e.g., any of Compositions 1.0 et seq.) are preferably selected from the group consisting of: 22 or C14 -C 22 The fatty alcohols contain saturated or unsaturated linear alkyl chains having 8 to 22 or 14 to 22 carbon atoms, respectively. For example, the fatty units of the ethers may be selected from decyl, cetyl, behenyl, arachidyl, stearyl, palmityl, myristyl, lauryl, capryl and hexadecanoyl units, and mixtures thereof, such as cetearyl.

[0118] In certain aspects, the fatty alcohol ether of a sugar may be any one selected from the group consisting of alkyl polyglucosides, such as the commercially available decyl glucoside and lauryl glucoside, cetearyl glucoside, optionally as a mixture with cetearyl alcohol, and additionally arachidyl glucoside, such as in the form of a mixture of arachidyl alcohol and behenyl alcohol with arachidyl glucoside.

[0119] In some aspects, sunscreens can include nonionic amphipathic lipids of sucrose monostearate, sucrose distearate, sucrose tristearate and mixtures thereof, methyl glucose and the distearate of polyglycerol-3 and alkyl polyglucosides. In some aspects, glycerol fatty acid esters that can be used as nonionic amphipathic lipids can be selected from the group consisting of: esters formed by at least one acid comprising a saturated linear alkyl chain with 16 to 22 carbon atoms and 1 to 10 glycerol units. For example, glycerol fatty acid esters can be used in the emulsions of the present disclosure. For example, esters can be selected from stearates, behenates, arachidates, palmitates and mixtures thereof.

[0120] In other aspects, the surfactant that can be used in the emulsion of the present disclosure (e.g., any of Compositions 1.0 et seq.) can be selected from: oleth-3 phosphate; cetearyl alcohol; cetearyl glucoside; decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate and decaglyceryl pentastearate (10 glycerol units) (CTFA name: polyglyceryl-10 stearate, polyglyceryl-10 distearate, polyglyceryl-10 tristearate, polyglyceryl-10 pentastearate), such as the products sold by Nikko Corporation under the respective names Nikkol Decaglyn 1-S, 2-S, 3-S and 5-S; and diglyceryl monostearate (CTFA name: polyglyceryl-2 stearate), such as the product sold by Nikko Corporation under the name Nikkol DGMS.

[0121] In certain additional aspects, sorbitan fatty esters may be used as nonionic amphiphilic lipids, wherein the esters are selected from the group consisting of: 16 -C 22 Esters of fatty acids with sorbitan and C 16 -C 22Oxyethylated esters of fatty acids and sorbitan. For example, they can be formed by at least one fatty acid and sorbitol or ethoxylated sorbitol, and the at least one fatty acid comprises at least one saturated linear alkyl chain having 16 to 22 carbon atoms respectively. In one aspect, the oxyethylated esters can comprise 1 to 100 ethylene oxide units. For example, these esters can be selected from stearates, behenates, arachidates, palmitates and mixtures thereof. In an example, the sorbitan fatty esters and the oxyethylated sorbitan fatty esters can be sorbitan monostearate (CTFA name: sorbitan stearate), sorbitan monopalmitate (CTFA name: sorbitan palmitate) or sorbitan 20EO tristearate (CTFA name: polysorbate 65).

[0122] In one aspect, the ethoxylated fatty ether may be an ether consisting of 1 to 100 ethylene oxide units and at least one fatty alcohol chain having 16 to 22 carbon atoms. The fatty chain of the ether may be chosen from behenyl, arachidyl, stearyl and cetyl units, and mixtures thereof, such as cetearyl. For example, the ethoxylated fatty ether may comprise: behenyl alcohol containing 5, 10, 20 and 30 ethylene oxide units (CTFA names: Beheneth-5, Beheneth-10, Beheneth-20 and Beheneth-30), and the ether of stearyl alcohol containing 2 ethylene oxide units (CTFA name: Steareth-2).

[0123] In one aspect, the ethoxylated fatty esters that can be used as nonionic amphiphilic lipids are esters consisting of 1 to 100 ethylene oxide units and at least one fatty acid chain comprising 16 to 22 carbon atoms. The fatty chain of the ester can be selected from, for example, stearate, behenate, arachidate and palmitate units and mixtures thereof. For example, the ethoxylated fatty esters can comprise: esters of stearic acid comprising 40 ethylene oxide units, and esters of behenic acid comprising 8 ethylene oxide units (CTFA name: PEG-8 Behenate).

[0124] In certain other aspects, the block copolymers of ethylene oxide and propylene oxide that can be used are selected from poloxamers, wherein the poloxamers are selected from: poloxamer 231, such as the product with formula (V) sold under the name Pluronic L81 by ICI, wherein x=z=6, y=39 (HLB 2); poloxamer 282, such as the product with formula (V) sold under the name Pluronic L92 by ICI, wherein x=z=10, y=47 (HLB 6); and poloxamer 124, such as the product with formula (V) sold under the name Pluronic L44 by ICI, wherein x=z=11, y=21 (HLB 16).

[0125] In other examples, any composition of the present disclosure (eg, any of Compositions 1.0 et seq.) can include a suitable hydrophobically modified emulsifier, such as inulin lauryl carbamate.

[0126] In some aspects, any composition of the present disclosure (e.g., any of Compositions 1.0 et seq.) may include silicone-based emulsifiers (e.g., polysiloxanes), glycosides, polyethylene glycols, acrylic emulsifiers, and mixtures thereof. For example, silicone-based emulsifiers may include Abil WE 09, Abil EM-90, DC 9011 silicone elastomer, Emulgade 68 / 50, Arlacel P135, Simulgel A, and Simulgel EG.

[0127] In some aspects, the total amount of emulsifier (if present) in the sunscreen composition can be 0.1 wt % to 30 wt %, based on the total weight of the sunscreen composition. In some cases, the total amount of emulsifier is 0.1 wt % to 20 wt %, 0.1 wt % to 15 wt %, 0.1 wt % to 10 wt %, 0.5 wt % to 30 wt %, 0.5 wt % to 20 wt %, 0.5 wt % to 15 wt %, 0.5 wt % to 10 wt %, 1 wt % to 30 wt %, 1 wt % to 20 wt %, 1 wt % to 15 wt %, 1 wt % to 10 wt %, based on the total weight of the sunscreen composition.

[0128] The sunscreen composition may optionally include one or more silicone oils. Non-limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyl trimethicone, trimethylsilyl amino dimethicone and stearoxy trimethylsilane. In some cases, the cosmetic composition includes dimethicone and optionally additional oil, including additional silicone oil. Typically, one or more silicone oils are non-volatile silicone oils. In some embodiments, the silicone oil is dimethicone (PDMS); dimethicone containing a side group of a silicone chain and / or an alkyl or alkoxy group at the end of the silicone chain, each of which contains 2 to 24 carbon atoms; or phenyl silicone, such as phenyl trimethicone, phenyl dimethicone, phenyl (trimethylsiloxy) diphenyl siloxane, diphenyl dimethicone, diphenyl (methyl diphenyl) trisiloxane or (2-phenylethyl) trimethylsiloxy silicate.

[0129] Other examples of silicone oils that may be mentioned include volatile linear or cyclic silicone oils, especially those with a viscosity of 8 centistokes (8×10 6 m 2 / s) and especially those containing 2 to 7 silicon atoms, these silicones optionally containing alkyl or alkoxy groups containing 1 to 10 carbon atoms. As volatile silicone oils that can be used in the present disclosure, mention may especially be made of octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane and dodecamethylpentasiloxane and mixtures thereof.

[0130] The total amount of silicone oil (if present) in the sunscreen composition can vary, but is generally about 0.1 wt % to about 40 wt %, based on the total weight of the sunscreen composition. In some cases, the total amount of silicone oil in the sunscreen composition can be about 0.1 wt % to about 30 wt %, about 0.1 wt % to about 20 wt %, about 0.1 wt % to about 10 wt %, about 1 wt % to about 40 wt %, about 1 wt % to about 30 wt %, about 1 wt % to about 20 wt %, about 1 wt % to about 10 wt %, about 5 wt % to about 40 wt %, about 5 wt % to about 30 wt %, about 5 wt % to about 20 wt %, or about 5 wt % to about 15 wt %, based on the total weight of the sunscreen composition.

[0131] In some aspects, the sunscreen composition of the present disclosure (e.g., any of Composition 1.0 et seq.) may be in the form of a cream, gel, paste, lotion, rinse, foam, emulsion, spray, etc. Sunscreen compositions may be prepared according to techniques known to those skilled in the art, particularly those intended for the preparation of oil-in-water or water-in-oil emulsions. For example, they may be in the form of a simple or complex emulsion (O / W, W / O, O / W / O or W / O / W emulsion) such as a cream or milky, in the form of a gel or cream-gel, or in the form of a lotion.

[0132] In certain aspects, the sunscreen composition of the present disclosure (e.g., any of compositions 1.0 et seq.) may comprise one or more SPF active ingredients selected from the following: any of the aforementioned compositions, wherein the one or more SPF active ingredients are selected from: octinoxate, octylsalicylate, homosalate, avobenzone, octocrylene, p-aminobenzoic acid, cinoxate, dihydroxybenzone, menthyl anthranilate, padimate O, ensolizole, sulfisobenzone, triethanolamine salicylate, ecamsule, 4-methylbenzylidene camphor, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, Parsol SLX (INCI Polysilicone-15), Butyl Methoxydibenzoylmethane, Ethylhexyl Methoxycinnamate, Ethylhexyl Salicylate, Benzophenone-3, Ethylhexyl Dimethyl PABA, Phenylbenzimidazole Sulfonic Acid, Benzophenone-4, Terphenyl Triazine, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Ethylhexyl Triazone, Methoxypropylaminocyclohexenyl Ethoxyethyl Cyanoacetate, Phenylene Bis-Diphenyl Triazine, Isoamyl p-Methoxycinnamate, Benzalkonium Camphor Sulfonic Acid, Camphor Benzalkonium Methosulfate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Disodium Phenyldibenzimidazole Tetrasulfonate, Drometrizole Trisiloxane, PEG-25 PABA, Polyacrylamidomethyl Benzylidene Camphor, Benzophenone-5, Benzophenone-8, Diethylhexyl Butamido Triazone, and combinations thereof.

[0133] In some aspects, octinoxate or octisalate is included in the composition as an SPF active ingredient.

[0134] In certain aspects, the sunscreen compositions of the present disclosure (e.g., any of compositions 1.0 et seq.) may contain additional inactive ingredients such as preservatives, fragrances, dyes, antioxidants, chelating agents, and the like.

[0135] In yet another aspect, any of the sunscreen compositions of the present disclosure (eg, any of compositions 1.0 et seq.) can include one or more antioxidants. For example, the antioxidants that can be used in the compositions of the present disclosure can be selected from: vitamins, such as vitamin C and its derivatives, such as ascorbyl acetate, phosphate and palmitate, magnesium ascorbyl phosphate; vitamin A and its derivatives; folic acid and its derivatives; vitamin E and its derivatives, such as tocopheryl acetate; flavonoids or flavonoids; amino acids, such as histidine, glycine, tyrosine, tryptophan and its derivatives; imidazoles, such as cis- or trans-urocanic acid and its derivatives; peptides, such as D,L-carnosine, D-carnosine, L-carnosine and its derivatives; carotenoids and carotenes, such as α-carotene, β-carotene, lycopene; uric acid and its derivatives; α-hydroxy acids, such as citric acid, lactic acid, malic acid; α-hydroxy fatty acids, such as palmitic acid, phytic acid, lactoferrin; stilbene and its derivatives; mannose and its derivatives; lipoic acid and its derivatives, such as dihydrolipoic acid; ferulic acid and its derivatives; thiols, such as glutathione, cysteine, cystine and its esters; folic acid and its derivatives; and combinations thereof.

[0136] In yet another aspect, the antioxidant or free radical scavenger that can be included in any of the sunscreen compositions of the present disclosure (e.g., any of compositions 1.0 et seq.) is a plant extract. For example, the antioxidant plant extract can be selected from the following: Angelica dahurica, Cassia bark, tea, Mediterranean cypress, Arabica coffee, Rhizoma Cibotii, Pongamia officinalis, rosemary, tree moss, oak moss, oats, and a mixture of two or more thereof.

[0137] In yet another aspect, any of the sunscreen compositions of the present disclosure (e.g., any of compositions 1.0 et seq.) comprises one or more vitamins and / or antioxidants selected from the group consisting of vitamin A (e.g., retinyl palmitate) and its derivatives, vitamin B1 (e.g., thiamine) and its derivatives, vitamin B2 (e.g., riboflavin) and its derivatives, vitamin B3 (e.g., niacin or niacinamide / nicotinamide) and its derivatives, vitamin B5 (e.g., pantothenic acid) and its derivatives, vitamin B6 (e.g., pyridoxine, pyridoxal or pyridoxamine) and its derivatives, vitamin B12 (e.g., cyanocobalamin) and its derivatives, vitamin B13 (e.g., thiamin) and its derivatives, vitamin B14 (e.g., thiamin) and its derivatives, vitamin B15 (e.g., thiamin) and its derivatives, vitamin B16 (e.g., pyridoxine, pyridoxal or pyridoxamine) and its derivatives, vitamin B17 (e.g., cyanocobalamin) and its derivatives, vitamin B18 (e.g., thiamin) and its derivatives, vitamin B19 (e.g., thiamin) and its derivatives, vitamin B20 (e.g., riboflavin) and its derivatives, vitamin B21 (e.g., thiamin) and its derivatives, vitamin B22 (e.g., thiamin) and its derivatives, vitamin B23 (e.g., riboflavin) and its derivatives, vitamin B24 (e.g., thiamin) and its derivatives, vitamin B25 (e.g., thiamin) and its derivatives, vitamin B26 (e.g., thiamin) and its derivatives, vitamin B Vitamin C (e.g., ascorbic acid) and its derivatives, vitamin E (e.g., tocopheryl acetate) and its derivatives, vitamin H (e.g., biotin) and its derivatives, vitamin K (e.g., vitamin K1) and its derivatives, and vitamin M (e.g., folic acid) and its derivatives, ubiquinone (also known as coenzyme Q10), glutathione, melatonin, resveratrol, citric acid, gallic acid and its esters, nordihydroguaiaretic acid, lipoic acid, dihydrolipoic acid, glycolic acid, α-arbutin, chitosan salicylate, rosmarinic acid, green tea extract, smithsonite extract, angelica dahurica extract, tea extract, Arabica coffee extract, Pongamia chinensis peel extract, and mixtures thereof.

[0138] In yet another aspect, any of the sunscreen compositions of the present disclosure (e.g., any of compositions 1.0 et seq.) may include one or more photostabilizers. For example, the photostabilizers that can be used in the compositions of the present disclosure may be selected from: Tinosorb S (USAN Bemotrizinol, INCI Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine); Tinosorb M (USAN Bisoctrizole, INCI Methylene Bis-Benzotriazolyl Tetramethylbutylphenol); Butyl Octyl Salicylate; Hexadecyl Benzoate; Butyl Octyl Benzoate; Corapan TQ (INCI 2,6-Diethylhexyl Naphthalate); Oxynex ST (INCI Diethylhexyl Eugenymalonate); Polycrylene (INCI Polyester-8); Ethylhexyl Triazone, Dioctyl Butamido Triazone, Benzalkonium Malonate Polysiloxane, Dibenzoylmethanesulfonate; Azolylphenylethylhexyliminotriazine, drometrizole trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol and bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl octyl salicylate, α-cyanodiphenylacrylate (e.g., ethylhexyl methoxypolyacrylonitrile or 2-ethylhexyl 2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate), isopentyl 4-methoxycinnamate, and combinations thereof.

[0139] In yet another aspect, any of the sunscreen compositions of the present disclosure (e.g., any of Compositions 1.0 et seq., etc.) may include a thickener or gelling agent, including substances that can increase the viscosity of the composition. Thickeners include those that can increase the viscosity of the composition without substantially changing the efficacy of the active ingredients in the sunscreen composition. Thickeners can also increase the stability of the sunscreen compositions of the present invention.

[0140] Non-limiting examples of additional thickeners that can be used in the context of the present invention include carboxylic acid polymers, cross-linked polyacrylate polymers, polyacrylamide polymers, polysaccharides and gums. Examples of carboxylic acid polymers include cross-linked compounds comprising one or more monomers derived from: acrylic acid, substituted acrylic acid, and salts and esters of these acrylic acid and substituted acrylic acid, wherein the cross-linking agent comprises two or more carbon-carbon double bonds and is derived from a polyol (see U.S. Pat. Nos. 5,087,445, 4,509,949, 2,798,053; CTFA International Cosmetic Ingredient Dictionary, Fourth Edition, 1991).

[0141] Non-limiting examples of cross-linked polyacrylate polymers include cationic polymers and nonionic polymers. Examples are described in U.S. Pat. Nos. 5,100,660, 4,849,484, 4,835,206, 4,628,078, 4,599,379.

[0142] Non-limiting examples of polyacrylamide polymers, including nonionic polyacrylamide polymers, including substituted branched or unbranched polymers, include polyacrylamide, isoparaffin and laureth-7, multi-block copolymers of acrylamide and substituted acrylamides with acrylic acid and substituted acrylic acid.

[0143] Non-limiting examples of polysaccharides include cellulose, carboxymethyl hydroxyethyl cellulose, cellulose acetate propionate carboxylate, hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxyethyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof. Another example is an alkyl-substituted cellulose, in which the hydroxyl groups of the cellulose polymer are hydroxyalkylated (preferably hydroxyethylated or hydroxypropylated) to form a hydroxyalkylated cellulose, which is then substituted with C 10 -C 30 The straight or branched alkyl groups are further modified by ether bonds. For example, these may include C 10 -C 30 Polymers of linear or branched alcohols and ethers of hydroxyalkyl cellulose.

[0144] Non-limiting examples of gums that can be used with the sunscreens of the present disclosure include acacia, agar, algin, alginic acid, ammonium alginate, pullulan, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar gum, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

[0145] Example

[0146] Example 1

[0147] Four non-limiting exemplary sunscreen compositions (Formulations 1 to 5) were prepared according to aspects of the present invention. The formulations of Formulations 1 to 5 are provided in Table 1 (below).

[0148] Table 1

[0149]

[0150] Example 2

[0151] Formulations 1 to 5 were evaluated to assess the SPF value, UVAI / UV ratio and critical wavelength of such sunscreen compositions. In order to calculate the critical wavelength of formulations 1 to 5, a sample of each of formulations 1 to 5 was placed in a polymethyl methacrylate (PMMA) plate suitable for UV transmittance measurement. Specifically, each corresponding sample was applied to the entire plate in a series of small dots and then spread evenly with a gloved finger. Spreading was performed for about 30 seconds with a very light spreading motion. The plate was then allowed to balance in the dark for 15 minutes before irradiation. The irradiation dose was equivalent to 800 J / m 2 The effective dose for erythema (i.e., 80 / J m 2 -efficient).

[0152] After irradiation, SPF-290S is used to determine the average transmittance value of each wavelength in the UV spectrum (290 nanometers to 400 nanometers). The transmittance value is measured at intervals of 1 nanometer. The measurement of the spectrum irradiation of each wavelength transmission by the PMMA plate coated with 15 microliters of glycerol is carried out 5 times, and is stored in the memory of the computer together with the average value of 5 measurements using SPF-290S, to obtain a reference reading. Subsequently, the PMMA plate coated with the test product is repeated for 5 times to measure, and the average value is calculated and stored so that the computer can then calculate the ratio of the average reference reading under each wavelength to the average test preparation reading, to calculate the average test preparation transmittance. The average transmittance value is then converted into an average absorbance value.

[0153] Three separate PMMA plates were used. Each plate was scanned five times at different locations, yielding a total of 15 measurements. The critical wavelength value was determined as the wavelength at which the integration of the spectral absorbance curve reaches 90% of the UV spectrum integral from 290 nm to 400 nm. An average critical wavelength of 370 nm or greater was classified as broad spectrum protection.

[0154] The static sun protection factor ("SPF") of the above formulations 1 to 5 was measured in accordance with FDA, 21 CFR Sec. 201.327, subpart (i), SPF Test Procedure, Sunscreen Drug Products for Over-the-Counter Human Use, Final Monograph, Federal Register, Vol. 76, No. 117, June 17, 2011, the contents of which are incorporated herein by reference in their entirety. Specifically, a series of five UV doses expressed in Joules / square meter were provided to 10 participants, increasing in increments of 25%. This formed the basis for the unprotected MEDu. The participants were asked to avoid additional UV exposure.

[0155] Participants were evaluated approximately 16 to 24 hours after the MEDu dose was completed to determine the response and unprotected minimum erythema dose ("MEDu") for each participant. MEDu is the amount of erythema effective energy. Subsequently, on day 2, a UV dose was applied and the protected MED ("MEDp") of the participant was determined according to the process of FDA, 21 CFR Sec, 201.327, subpart 4 (iii) and FDA, 21 CFR Sec, 201.327, subpart 5 (iii), the contents of which are incorporated herein by reference in their entirety. Participants were then evaluated approximately 16 to 24 hours after the completion of the UV dose on day 2. The MED of all sites (both protected and unprotected) receiving the UV dose was assessed. The SPF values ​​for all of Formulations 1 through 5 were calculated based on FDA standards using FDA, 21 CFR Sec 201.327, first (i) subpart (6) by dividing the MEDp value produced in the sunscreen-protected area by the MEDu value produced in the unprotected test area, using the following calculation for each participant:

[0156] MEDip / MEDiu=SPFi value

[0157] Data from 10 participants were used to calculate the label SPF values ​​for the test formulations (i.e., formulations 1 to 5). The mean SPF value and standard deviation for the participants were also calculated.

[0158] A summary of the UVAI / UV ratios, SPF values, and critical wavelengths for Formulations 1 through 5 is provided in Table 2 (below).

[0159] Table 2

[0160]

[0161] As is clear from the table above, the addition of SPF enhancing ingredients increases the UVAI / UV ratio to over 0.7, increases the SPF to over 40, and increases the critical wavelength to over 370. Non-limiting exemplary compositions comprising certain combinations of SPF enhancing ingredients and UV filters unexpectedly achieve the desired SPF while meeting the required UVAI / UV ratio. In addition, Formulations 1 and 2 achieve improvements in SPF values ​​and UVAI / UV ratios while having a reduced total amount of UV filters compared to market-based formulations, which is unexpected.

[0162] Example 3

[0163] The qualitative aspects of formulations 1 to 5 from Example 1 were evaluated by a clinical trial using eight panelists. A summary of the qualitative aspects and scoring methods for formulations 1 to 5 is provided in Tables 3 to 5. For Tables 3 and 4, higher values ​​are assigned to formulations that exhibit more evaluated characteristics, while lower values ​​are assigned to formulations that exhibit fewer evaluated characteristics. The viscosity in Table 4 was measured using a viscometer.

[0164] Table 3

[0165]

[0166] Table 4

[0167] Preparation 1 Preparation 2 Preparation 3 Preparation 4 Preparation 5 Wettability 1 / 8 3 / 8 4 / 8 6 / 8 3 / 8 Spreadability 0 / 8 2 / 8 6 / 8 7 / 8 3 / 8 Absorbance 1 / 8 2 / 8 6 / 8 7 / 8 2 / 8 thickness 8 / 8 7 / 8 0 / 8 1 / 8 6 / 8 Whiteness 7 / 8 6 / 8 0 / 8 0 / 8 6 / 8 viscosity 5 / 8 1 / 8 2 / 8 0 / 8 2 / 8 The amount of residue 7 / 8 4 / 8 0 / 8 2 / 8 5 / 8 Lubricity 3 / 8 3 / 8 7 / 8 3 / 8 4 / 8 Preference 2 / 8 3 / 8 8 / 8 6 / 8 3 / 8 Viscosity(cP) 19100 15100 13900 15900 17400

[0168] Table 5 - Scores

[0169] The number of times the attribute is selected Summary 0-1 Statistically significant 2-6 Not statistically significant 7-8 Statistically significant

[0170] The above scores are based on the selection of formulations relative to the market-based formulation described in Example 2. For example, eight (out of eight) panelists preferred Formulation 3 relative to the market-based formulation, and six (out of eight) panelists preferred Formulation 4 relative to the market-based formulation.

[0171] Example 4

[0172] Five non-limiting exemplary sunscreen compositions (Formulations 6 to 10) were prepared according to aspects of the present disclosure. The formulations of such sunscreen compositions are provided in Table 6 (below).

[0173] Table 6

[0174]

[0175] Example 5

[0176] Five non-limiting exemplary sunscreen compositions (Formulations 11 to 15) were prepared according to aspects of the present disclosure. The formulations of such sunscreen compositions are provided in Table 7 (below).

[0177] Table 7

[0178]

[0179] Example 6

[0180] Seven compositions (Formulations 16 to 22) were prepared according to aspects of the present invention. Formulations 16 to 22 were evaluated according to the procedure described in Example 2 to determine SPF values ​​and UVAI / UV ratios. The change in SPF value (ΔSPF) relative to Formulation 16 used as a control was calculated. X-制剂16 ). A summary of the formulations of Formulations 16 to 22 and the SPF values ​​and UVAI / UV ratios for each corresponding composition is provided in Table 8 (below).

[0181] Table 8

[0182]

[0183]

[0184] As seen in Table 8, certain combinations of SPF active ingredients, metal oxides, photostabilizers, and / or antioxidants achieve significant increases in UVAI / UV ratios while simultaneously achieving the desired SPF values. In addition, the significant increase in SPF values ​​achieved by Formulation 22 with the increase in UVAI / UV ratio is unexpected in light of Formulation 17, which suggests that the addition of butyl octyl salicylate to octyl octyl ester and zinc oxide reduces the SPF value and UVAI / UV ratio of the sunscreen composition; in light of Formulation 20, which suggests that the addition of ethylhexyl methoxy polyacrylonitrile and Pongamia extract to octyl octyl ester and zinc oxide reduces the SPF value and UVAI / UV ratio of the sunscreen composition; and in light of Formulation 21, which suggests that the addition of butyl octyl salicylate and ethylhexyl methoxy polyacrylonitrile to octyl octyl ester and zinc oxide reduces the SPF value and UVAI / UV ratio of the sunscreen composition. Formulation 22 was further evaluated by in vivo testing and was determined to have an SPF value of 52.

[0185] Formulation 22 and the market-based formulation from Example 1 were evaluated by an expert panel to rate the whiteness of these formulations. Formulation 22 showed similar whiteness to the market-based formulation, which was unexpected because Formulation 22 contained approximately 22% more zinc oxide than the market-based formulation.

[0186] Example 7

[0187] Eight compositions (Formulations 23 to 30) were prepared according to aspects of the present invention. Formulations 23 to 30 were evaluated according to the process described in Example 2 to determine the SPF value and UVAI / UV ratio. The formulas of Formulations 23 to 30 and the summary of the SPF value and UVAI / UV ratio of each corresponding composition are provided in Table 9.

[0188] Table 9

[0189]

[0190]

[0191]

[0192] As seen in Table 9 (above), certain combinations of SPF active ingredients, metal oxides, photostabilizers, and / or antioxidants achieve significant increases in UVAI / UV ratios while simultaneously achieving desired SPF values. The significant increases in SPF values ​​and UVAI / UV ratios achieved by certain sunscreen compositions disclosed in Table 9 (e.g., but not limited to, Formulations 27 and 30) are unexpected and surprising.

[0193] Formulation 30 and the market-based formulation from Example 1 were evaluated by an expert panel to assess the whiteness of these formulations. Formulation 30 showed similar whiteness to the market-based formulation, which was unexpected because Formulation 30 contained approximately 22% more zinc oxide than the market-based formulation. Formulation 30 was evaluated according to the in vivo test and was determined to have an SPF of 51.

[0194] Example 8

[0195] A composition (Formulation 31) was prepared according to aspects of the present invention. Formulation 31 was evaluated according to the process described in Example 2 to determine the SPF value and UVAI / UV ratio. The formula of Formulation 31 and a summary of the SPF value and UVAI / UV ratio of Formulation 31 are provided in Table 10.

[0196] Table 10

[0197]

[0198]

[0199] Example 9

[0200] A composition (Formulation 32) was prepared according to aspects of the present invention. The formulation of Formulation 32 is provided in Table 11.

[0201] Table 11

[0202]

[0203]

[0204] Formulation 32 was evaluated by an expert panel in comparison to the market-based formulation from Example 1 to assess the whiteness of Formulation 32. The expert panel applied samples of the respective compositions and evaluated the whiteness of the respective samples after three rubs during application, after twelve rubs during application, at the end of application of the sample, instantaneous whiteness, and whiteness after five minutes. Table 12 includes a summary of the evaluation of Formulation 32 and the market-based formulation.

[0205] Table 12

[0206]

[0207] As seen in Table 12, Formulation 32 exhibits lower whiteness than the commercially based formulation. This is unexpected because Formulation 32 has approximately 22% more zinc oxide than the commercially based formulation.

[0208] The present invention has been described above with reference to illustrative embodiments, but it should be understood that the present invention is not limited to the disclosed embodiments. Changes and modifications that may be made by those skilled in the art after reading this specification are also within the scope of the present invention, and the scope of the present invention is defined in the appended claims.

Claims

1. A sunscreen composition comprising: From about 5% to about 25% by weight of a metal oxide, relative to the total weight of the sunscreen composition; One or more SPF active ingredients; and one or more SPF enhancing components, the one or more SPF enhancing components comprising a light stabilizer, an antioxidant, or a combination thereof, The sunscreen has a UVAI / UV ratio greater than or equal to 70 and an SPF greater than or equal to 40.

2. The sunscreen composition of claim 1, wherein the metal oxide is selected from the group consisting of: Ba, Zn, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Re, Os, Ir and Sn.

3. The sunscreen composition of claim 1 or claim 2, wherein the metal oxide comprises zinc oxide, titanium oxide or a combination thereof.

4. The sunscreen composition according to any preceding claim, wherein the metal oxide is present in an amount of about 5 wt% to about 15 wt%, relative to the total weight of the sunscreen composition.

5. A sunscreen composition according to any preceding claim, wherein the one or more SPF active ingredients are selected from octinoxate, octylsalicylate, homosalate, avobenzone, para-aminobenzoic acid, cinoxate, dioxybenzone, menthyl anthranilate, octocrylene, padimate O, ensolazole, sulfisobenzone, triethanolamine salicylate, ecamsule, 4-methylbenzylidene camphor, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, Parsol SLX (INCI polysilicone-15), butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, ethylhexyl salicylate, benzophenone-3, di Ethylhexyl methyl PABA, phenylbenzimidazole sulfonic acid, benzophenone-4, terphenyl triazine, bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, ethylhexyl triazone, methoxypropylaminocyclohexenylene ethoxyethyl cyanoacetate, phenylene bis-diphenyl triazine, isopentyl p-methoxycinnamate, benzalkonium camphor sulfonic acid, camphor benzalkonium methylsulfate, diethylamino hydroxybenzoyl hexyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, drometrizole trisiloxane, PEG-25 PABA, polyacrylamidomethylbenzylidene camphor, benzophenone-5, benzophenone-8, diethylhexyl butyramido triazone, and combinations of two or more thereof.

6. A sunscreen composition according to any preceding claim, wherein the SPF active ingredient comprises octinoxate, octylsalicylate or a combination thereof.

7. The sunscreen composition according to any preceding claim, wherein the SPF active ingredient is present in an amount of about 1 wt% to about 10 wt% relative to the total weight of the sunscreen composition.

8. The sunscreen composition according to any preceding claim, wherein the photostabilizer comprises butyl octyl salicylate, ethylhexyl methoxy polyacrylonitrile, or a combination thereof.

9. The sunscreen composition according to any preceding claim, wherein the light stabilizer is present in an amount of about 0.5 wt% to about 10 wt% relative to the total weight of the sunscreen composition.

10. A sunscreen composition according to any preceding claim, wherein the SPF enhancing ingredient comprises an antioxidant.

11. The sunscreen composition according to claim 10, wherein the antioxidant is selected from Angelica archangelica, Arnica montana, Camellia sinensis, Cupressus semper, Coffee arabica, Polygonatum multiflorum, Pongamia pinnata extract, Rosmarinus officinalis, Evernia fufuracea, Evernia prunastri, Aventa sativa, vitamin A, vitamin E, peptides, flavonoids, flavonols, and combinations thereof.

12. The sunscreen composition of claim 11, wherein the antioxidant comprises Pongamia chinensis extract.

13. The sunscreen composition of claim 12, wherein the Pongamia chinensis seed extract is present in an amount of about 0.05 wt% to about 5 wt% relative to the total weight of the sunscreen composition.

14. The sunscreen composition according to any preceding claim, wherein the SPF enhancing ingredient is present in an amount of about 0.05 wt. % to about 10 wt. %, relative to the total weight of the sunscreen composition.

15. A sunscreen composition according to any preceding claim, wherein the light stabilizer is selected from ethylhexyl triazone, dioctyl butyramido triazone, benzalmalonate polysiloxane, bisbenzo Azolylphenylethylhexyliminotriazine, drometrizole trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol and bis-ethylhexyloxyphenol methoxyphenyl triazine, butyl octyl salicylate, α-cyanodiphenylacrylate (e.g., ethylhexyl methoxypolyacrylonitrile or 2-ethylhexyl 2-cyano-3-(4-methoxyphenyl)-3-phenylacrylate), isopentyl 4-methoxycinnamate, diethylhexyl syringylidenemalonate, diethylhexyl 2,6-naphthalene dicarboxylate, octocrylene, and combinations thereof.

16. A sunscreen composition according to any preceding claim, wherein the sunscreen composition comprises: Zinc oxide; Ocinolide, octinoxate, or a combination thereof; and Butyloctyl salicylate, ethylhexyl methoxy polyacrylonitrile, Pongamia chinensis peel extract or a combination thereof.

17. The sunscreen composition according to one of claims 1 to 15, wherein the sunscreen composition comprises: from about 5 wt % to about 15 wt % zinc oxide; Optionally, from about 1 wt % to about 10 wt % octyl salicylate; from about 0.5 wt % to about 5 wt % butyl octyl salicylate; From about 0.5 wt. % to about 5 wt. % ethylhexylmethoxypolyacrylonitrile; and about 0.05% to 1% by weight of Pongamia chinensis extract, All weight percentages are relative to the total weight of the sunscreen composition.

18. The sunscreen composition according to one of claims 1 to 15, wherein the sunscreen composition comprises: from about 5 wt % to about 15 wt % zinc oxide; Optionally, about 0.1 wt % to 2 wt % titanium dioxide; Optionally, from about 1 wt % to about 10 wt % octyl salicylate; from about 0.5 wt % to about 5 wt % butyl octyl salicylate; From about 0.5 wt. % to about 5 wt. % ethylhexylmethoxypolyacrylonitrile; and about 0.05% to about 1% by weight of Pongamia chinensis extract, All weight percentages are relative to the total weight of the sunscreen composition.

19. The sunscreen composition according to one of claims 1 to 15, wherein the sunscreen composition comprises: from about 5 wt % to about 15 wt % zinc oxide; Optionally, from about 1 wt % to about 10 wt % of orcinol ester; from about 0.5 wt % to about 5 wt % butyl octyl salicylate; From about 0.5 wt. % to about 5 wt. % ethylhexylmethoxypolyacrylonitrile; and about 0.05% to 1% by weight of Pongamia chinensis extract, All weight percentages are relative to the total weight of the sunscreen composition.

20. A sunscreen according to any preceding claim, wherein the sunscreen composition further comprises water.

21. The sunscreen composition according to any preceding claim, wherein the UVAI / UV ratio is greater than, or equal to, 70, and the SPF is greater than, or equal to, 40.

22. The sunscreen composition according to any preceding claim, wherein the sunscreen is in the form of a cream, gel, paste, lotion, rinse, foam, emulsion, spray, or a combination thereof.

23. The sunscreen composition according to any preceding claim, further comprising one or more ingredients selected from the group consisting of tanning agents, free radical scavengers, vitamins, enzymes, herbal ingredients, polymers, antioxidants, omega-3 / 6 fatty acids, and combinations of two or more thereof.

24. A method of increasing the SPF of a sunscreen composition according to any one of the preceding claims, wherein the method comprises adding one or more SPF enhancing ingredients.

25. The method of claim 24, wherein the one or more SPF enhancing ingredients are selected from the group consisting of butyloctyl salicylate, ethylhexylmethoxypolyacrylonitrile, Pongamia chinensis peel extract, and combinations thereof.

26. A sunscreen composition comprising: An SPF enhancing component comprising Pongamia chinensis extract, ethylhexyl methoxy polyacrylonitrile, butyl octyl salicylate, or a combination of two or more thereof; and At least one of an organic UV filter or a metal oxide.

27. The sunscreen composition of claim 26, wherein the SPF enhancing component comprises two or more of Pongamia chinensis extract, ethylhexyl methoxy polyacrylonitrile, or butyloctyl salicylate.

28. A sunscreen composition according to claim 26 or claim 27, wherein the SPF enhancing component comprises Pongamia chinensis extract and ethylhexyl methoxy polyacrylonitrile.

29. The sunscreen composition of one of claims 26 to 28, wherein the SPF enhancing component comprises Pongamia chinensis extract, ethylhexyl methoxypolyacrylonitrile and butyloctyl salicylate.

30. Sunscreen composition according to one of claims 26 to 29, wherein the organic UV filter is octyl salicylate.

31. The sunscreen composition according to claim 32, wherein the organic UV filter is octinoxate.

32. The sunscreen composition of claim 26, wherein the SPF enhancing component consists of Pongamia chinensis extract and the organic UV filter is octinoxate.

33. The sunscreen composition according to claim 26 , wherein the organic UV filter is selected from the group consisting of octinoxate, octylsalicylate, homosalate, avobenzone, para-aminobenzoic acid, cinoxate, dioxybenzone, menthyl anthranilate, octocrylene, padimate O, ensolazole, sulfisobenzone, triethanolamine salicylate, ecamsule, 4-methylbenzylidene camphor, diethylaminohydroxybenzoyl hexyl benzoate, bis-diethylaminohydroxybenzoyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, Parsol SLX (INCI polysilicone-15), butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, ethylhexyl salicylate, benzophenone-3 , dimethyl PABA ethylhexyl ester, phenylbenzimidazole sulfonic acid, benzophenone-4, terphenyl triazine, bis-ethylhexyloxyphenol methoxyphenyl triazine, methylene bis-benzotriazolyl tetramethylbutylphenol, ethylhexyl triazone, methoxypropylaminocyclohexenyl ethoxyethyl cyanoacetate, phenylene bis-diphenyl triazine, isopentyl p-methoxycinnamate, benzalkonium methylsulfate, camphor benzalkonium methylsulfate, diethylamino hydroxybenzoyl hexyl benzoate, disodium phenyl dibenzimidazole tetrasulfonate, drometrizole trisiloxane, PEG-25 PABA, polyacrylamidomethyl benzalkonium camphor, benzophenone-5, benzophenone-8, diethylhexyl butyramido triazone, and combinations of two or more thereof.

34. The sunscreen composition of one of claims 26 to 33, wherein the metal oxide comprises titanium oxide, iron oxide, zinc oxide, zirconium oxide, cerium oxide, or a combination of two or more thereof.

35. The sunscreen composition of one of claims 26 to 34, wherein the metal oxide comprises zinc oxide, titanium oxide, or a combination thereof.

36. The sunscreen composition according to one of claims 26 to 28, wherein the sunscreen composition is essentially free of or free of organic UV filters.

37. The sunscreen composition according to one of claims 26 to 36, wherein the UVAI / UV ratio of the sunscreen composition is greater than or equal to 70.

38. The sunscreen composition according to one of claims 26 to 37, wherein the SPF value of the sunscreen composition is greater than or equal to 40.3.

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