She medicine swelling and pain relieving formula used after fracture operation and preparation method of She medicine swelling and pain relieving formula

Abstract

The invention discloses a traditional She medicine swelling and pain relieving formula used after fracture operation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 14-16 parts of illicium henryi root, 8-10 parts of wikstroemia indica, 14-16 parts of elderberry, 14-16 parts of ampelopsis grossedentata root, 14-16 parts of Chinese aralis root, 14-16 parts of white peach root, 14-16 parts of ginger, 14-16 parts of melastoma dodecandrum, 8-10 parts of flammulina velutipes root, 8-10 parts of mulberry root and 0.5-2 parts of borneol. According to the traditional She medicine for relieving swelling and pain, all the medicines are combined to achieve the effects of relaxing muscles and stimulating blood circulation, dissipating blood stasis and relieving pain, detoxifying and relieving swelling, clearing and activating the channels and collaterals, clearing heat and promoting diuresis, and setting bones and reunion tendons; the external application of the formula can treat bone fracture and tendon injury, also has the effects of relieving swelling and pain, clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, and can obviously relieve the symptoms of limb swelling, pain, skin temperature rise and the like occurring after fracture surgery.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a She medicine prescription for reducing swelling and relieving pain used after fracture surgery and a preparation method thereof. Background Art

[0002] The pain and swelling after fracture surgery are usually caused by poor venous blood return. The affected area will have symptoms such as persistent swelling, pain, and increased skin temperature, which will have an adverse effect on the patient's prognosis.

[0003] In this regard, current care mostly involves measures such as fixation, elevation, and local hot compresses of the fractured bones; however, regardless of whether the broken bones are fixed or not, there is little effect on relieving symptoms such as swelling, pain, and increased skin temperature in the affected area. Summary of the invention

[0004] The invention aims to provide a She medicine detumescence and analgesia prescription for use after fracture surgery to relieve symptoms such as swelling, pain, and increased skin temperature of the affected area after fracture surgery.

[0005] To achieve the above-mentioned object of the invention, the technical solution of the present invention is as follows:

[0006] A She medicine prescription for reducing swelling and relieving pain used after fracture surgery, the raw materials of which include, by weight: 14-16 parts of red fennel roots, 8-10 parts of Rhizoma Leonuri, 14-16 parts of elderberry, 14-16 parts of ampelopsis roots, 14-16 parts of Aralia oleifera roots, 14-16 parts of Prunus armeniaca roots, 14-16 parts of Ginger, 14-16 parts of Radix Angelicae Pubescentis, 8-10 parts of Ligusticum wallichii roots, 8-10 parts of Morus alba roots and 0.5-2 parts of borneol.

[0007] The She medicine swelling and analgesic prescription of the present invention uses red fennel root, safflower seed and elderberry as main medicines. The red fennel root has the effects of dispelling wind and unblocking meridians, promoting blood circulation, dispersing blood stasis and relieving pain. The safflower seed has the effects of clearing away heat and detoxifying, dispersing knots and removing blood stasis, promoting diuresis and killing insects. The elderberry has the effects of dispelling wind and dampness, promoting blood circulation and stopping bleeding, and is particularly effective for traumatic injuries, bone fracture swelling and pain, and traumatic bleeding. The root of snake grape has the effects of relaxing muscles and promoting blood circulation, reducing swelling and detoxifying, promoting tissue regeneration and relieving pain, and antibacterial and anti-inflammatory. The root of Aralia dasyphylla has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, dispersing wind and removing dampness, and strengthening the spleen and promoting diuresis. The root of white peach has the effects of dispelling wind and dampness, promoting blood circulation and setting bones. The monkey ginger has the effects of promoting blood circulation and stopping pain, and tonifying the kidney and strengthening bones. It is mainly used for It is used for bruises, bone and tendon setting, and is the assistant drug; the herb Radix Dichroae has the effects of promoting blood circulation and stopping bleeding, promoting dampness and unblocking collaterals; the root of golden needle has the effects of clearing away heat and removing dampness, cooling blood and stopping bleeding, and detoxifying and reducing swelling; the root of Morus alba has the effects of clearing away heat and relieving exterior symptoms, promoting lung function and relieving cough; it is mainly used for clearing heat and detoxifying, promoting blood circulation and stopping bleeding, and is the adjuvant drug; borneol has the effects of invigorating the mind, clearing away heat and relieving pain, and is the guiding drug; all the drugs are used together to achieve the effects of relaxing muscles and activating blood circulation, dispersing blood stasis and relieving pain, detoxifying and reducing swelling, unblocking meridians and activating collaterals, clearing away heat and removing dampness, and connecting bones and tendons; external application of this prescription can treat bone breaks and tendon injuries, and it also has the effects of reducing swelling and relieving pain, clearing away heat and detoxifying, and having antibacterial and anti-inflammatory effects, and can significantly reduce symptoms such as limb swelling, pain, and increased skin temperature that occur after fracture surgery.

[0008] Preferably, the raw materials of the She medicine swelling and analgesic prescription used after fracture surgery include, by weight: 15 parts of red fennel root, 9 parts of Rhizoma Leonuri, 15 parts of elderberry, 15 parts of snake grape root, 15 parts of Aralia tataricus root, 15 parts of white peach root, 15 parts of ginger, 15 parts of ground radix, 9 parts of golden needle root, 9 parts of Morus alba root, and 1 part of borneol.

[0009] The present invention also provides a method for preparing the above-mentioned She medicine swelling and pain relief prescription used after fracture surgery, the preparation method comprising:

[0010] (1) Grinding each raw material into powder and mixing according to a preset mass ratio;

[0011] (2) Add rice wine and mix into a paste.

[0012] Alternatively: (1) mixing the raw materials according to a preset mass fraction and grinding them into powder;

[0013] (2) Add rice wine and mix into a paste.

[0014] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0015] The She medicine swelling and analgesic prescription of the present invention uses red fennel root, safflower seed and elderberry as main medicines. The red fennel root has the effects of dispelling wind and unblocking meridians, promoting blood circulation, dispersing blood stasis and relieving pain. The safflower seed has the effects of clearing away heat and detoxifying, dispersing knots and removing blood stasis, promoting diuresis and killing insects. The elderberry has the effects of dispelling wind and dampness, promoting blood circulation and stopping bleeding, and is particularly effective for traumatic injuries, bone fracture swelling and pain, and traumatic bleeding. The root of snake grape has the effects of relaxing muscles and promoting blood circulation, reducing swelling and detoxifying, promoting tissue regeneration and relieving pain, and antibacterial and anti-inflammatory. The root of Aralia dasyphylla has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, dispersing wind and removing dampness, and strengthening the spleen and promoting diuresis. The root of white peach has the effects of dispelling wind and dampness, promoting blood circulation and setting bones. The monkey ginger has the effects of promoting blood circulation and stopping pain, and tonifying the kidney and strengthening bones. It is mainly used for It is used for bruises, bone and tendon setting, and is the assistant drug; the herb Radix Dichroae has the effects of promoting blood circulation and stopping bleeding, promoting dampness and unblocking collaterals; the root of golden needle has the effects of clearing away heat and removing dampness, cooling blood and stopping bleeding, and detoxifying and reducing swelling; the root of Morus alba has the effects of clearing away heat and relieving exterior symptoms, promoting lung function and relieving cough; it is mainly used for clearing heat and detoxifying, promoting blood circulation and stopping bleeding, and is the adjuvant drug; borneol has the effects of invigorating the mind, clearing away heat and relieving pain, and is the guiding drug; all the drugs are used together to achieve the effects of relaxing muscles and activating blood circulation, dispersing blood stasis and relieving pain, detoxifying and reducing swelling, unblocking meridians and activating collaterals, clearing away heat and removing dampness, and connecting bones and tendons; external application of this prescription can treat bone breaks and tendon injuries, and it also has the effects of reducing swelling and relieving pain, clearing away heat and detoxifying, and having antibacterial and anti-inflammatory effects, and can significantly reduce symptoms such as limb swelling, pain, and increased skin temperature that occur after fracture surgery. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The preoperative NRS scores of the 60 patients tested;

[0017] Figure 2 The circumference and swelling values ​​of the bilateral wrist joints of the 60 patients before surgery;

[0018] Figure 3 The skin temperature and temperature difference of bilateral wrist joints of 60 patients before surgery;

[0019] Figure 4 This is the NRS score of the 60 patients on the first day after surgery;

[0020] Figure 5 This is the NRS score of the 60 patients on the third day after surgery;

[0021] Figure 6 This is the NRS score of the 60 patients on the 7th day after surgery;

[0022] Figure 7 The summary of NRS scores of the 60 patients on the 1st, 3rd, and 7th days after surgery and the linear trend of pain on the 3rd day for experienced hands;

[0023] Figure 8 The circumference and swelling values ​​of the bilateral wrist joints of the 60 patients on the first day after surgery;

[0024] Fig. 9 The circumference and swelling values ​​of the bilateral wrist joints of the 60 patients on the third day after surgery;

[0025] Fig.10 The circumference and swelling values ​​of the bilateral wrist joints of the 60 patients on the 7th day after surgery;

[0026] Fig.11 The summary of wrist swelling values ​​of the 60 patients on days 1, 3, and 7 after surgery and the linear trend of swelling on day 7 after surgery;

[0027] Fig.12 The skin temperature and temperature difference of the bilateral wrist joints of the 60 patients on the first day after surgery;

[0028] Fig.13 The skin temperature and temperature difference of the bilateral wrist joints of the 60 patients on the third day after surgery;

[0029] Fig.14 The skin temperature and temperature difference of the bilateral wrist joints of the 60 patients on the 7th day after surgery;

[0030] Fig.15 The summary of wrist temperature difference values ​​on the 1st, 3rd and 7th days after surgery and the linear trend of temperature difference on the 3rd day after surgery for the 60 patients tested;

[0031] Fig.16 This is the Gartland-Werley score of the 60 patients at the last follow-up one year after surgery. DETAILED DESCRIPTION

[0032] The technical solution of the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0033] Example 1

[0034] The present embodiment provides a She medicine prescription for reducing swelling and relieving pain used after fracture surgery, and its raw materials are composed of: 15 parts of red fennel root, 9 parts of Rhizoma Dioscoreae, 15 parts of elderberry, 15 parts of ampelopsis root, 15 parts of Aralia oleifera root, 15 parts of Prunus armeniaca root, 15 parts of Ginger, 15 parts of Radix Angelicae Pubescentis, 9 parts of Ligusticum wallichii root, 9 parts of Morus alba root, and 1 part of borneol.

[0035] The preparation method of the She medicine swelling-removing and analgesic prescription used after fracture surgery is as follows:

[0036] (1) Grinding each raw material into powder and mixing according to a preset mass ratio;

[0037] (2) Add rice wine and mix into a paste.

[0038] When using, apply the prescription externally to the affected area where symptoms such as swelling, pain, and high skin temperature occur.

[0039] The present invention includes 60 voluntary patients and randomly divides them into 2 groups: a control group and a test group; the control group and the test group are given medication respectively to verify the efficacy of the She medicine swelling and analgesia prescription of the present invention (the control group is not given medication).

[0040] First, the preoperative NRS scores, swelling values, temperature difference values, WBC counts, CRP, ESR and other data of the two groups of patients were compared. The comparison results are shown in Table 1, Figure 1 , Figure 2 and Figure 3 shown.

[0041] Table 1 Baseline data of preoperative observation indicators of the two groups of patients

[0042]

[0043] In the table, the NRS pain score is based on the NRS digital grading scale method, and the test results are shown in Figure 1 ;

[0044] The swelling value is calculated as follows: first use a soft tape measure to measure the circumference of the patient's bilateral wrist creases (cm), and then use the following formula to calculate the swelling value:

[0045] Swelling value = affected wrist circumference - healthy wrist circumference; test results are shown in Figure 2 ;

[0046] The temperature difference is calculated as follows: first use a thermometer to measure the skin temperature (°C) of the symmetrical parts of the patient's wrist joints on both sides, and then use the following formula to calculate the temperature difference:

[0047] Temperature difference = affected wrist joint skin temperature - healthy wrist joint skin temperature; test results are shown in Figure 3 .

[0048] As can be seen from Table 1, the P values ​​of preoperative NRS score, swelling value, temperature difference value, WBC count, CRP, and ESR in the control group and the experimental group were all greater than 0.05, with no statistical difference. Therefore, the data of the control group and the experimental group are comparable.

[0049] The She medicine swelling and analgesia prescription prepared in this embodiment was applied to the affected wrist joint of the patients in the test group after surgery, and the dressing was changed every day, while the control group was not applied with the medicine; then, the NRS scores, swelling values, temperature difference values, WBC counts, CRP, ESR and other indicators of the patients in the test group and the control group were tested again on the 1st, 3rd and 7th days after surgery; wherein, the NRS score was performed before each dressing change, and the test results are shown in Table 1. Figure 4 , Figure 5 , Figure 6 and Figure 7The swelling value and skin temperature were tested after each removal of the dressing. The test results of wrist joint circumference and swelling value are shown in Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown; the test results of wrist joint skin temperature and temperature difference are shown in Fig.12 , Fig.13 , Fig.14 and Fig.15 As shown; the test results of the two groups of patients on the first day after surgery are shown in Table 2, the test results on the third day after surgery are shown in Table 3, and the test results on the seventh day after surgery are shown in Table 4.

[0050] Table 2 Observation indexes of the two groups of patients on the first day after surgery

[0051]

[0052] As shown in Table 2, among the 60 patients included in the study, the P values ​​of NRS score, swelling value, temperature difference value, WBC count, CRP, and ESR on the first day after surgery in the control group and the experimental group were all > 0.05, with no statistical difference and comparable.

[0053] Table 3 Observation indexes of the two groups of patients on the third day after surgery

[0054]

[0055] As shown in Table 3, among the 60 patients included in the study, the P values ​​of NRS score, swelling value and temperature difference value on the third day after surgery between the control group and the experimental group were all <0.001, which showed significant statistical differences.

[0056] Table 4 Observation indexes of the two groups of patients on the 7th day after surgery

[0057]

[0058]

[0059] As shown in Table 4, among the 60 patients included in the study, the P values ​​of NRS score, swelling value and temperature difference value on the 7th day after surgery in the control group and the experimental group were all <0.05, which were statistically significant; but the P values ​​of WBC, CRP and ESR were all >0.05, which were not statistically significant.

[0060] The patients were followed up after discharge, and wrist joint X-ray or CT examination was performed during the follow-up to measure the wrist joint range of motion and muscle strength, and to observe whether complications such as pain, deformity, and limited movement occurred.

[0061] At the final follow-up one year after surgery, the wrist function was assessed using the Gartland-Werley scoring standard, which included residual deformity, subjective evaluation, objective evaluation, and complications. The final results were divided into four grades: excellent, good, fair, and poor. The grading standard was as follows: excellent: 0-2 points; good: 3-8 points; fair: 9-20 points; poor: ≥21 points. The Gartland-Werley scoring results are shown in Tables 5 and Fig.16 shown.

[0062] Table 5 Wrist GW scores of the two groups of patients one year after surgery

[0063]

[0064] From Table 5 and Fig.16 It can be seen that all 60 patients included in the study received effective follow-up. At the last follow-up, the Gartland-Werley score of wrist joint function was: residual deformity 0.62±0.14 points, subjective evaluation 1.32±0.36 points, objective evaluation 1.14±0.26 points, complications 0.82±0.12 points, and the average total score was 3.90±4.06 points; among them, the Gartland-Werley score of the experimental group was 2.80±3.10, and the Gartland-Werley score of the control group was 5.00±4.62, P value <0.05, which was statistically significant.

[0065] At the last follow-up one year after surgery, wrist function was evaluated in 60 patients with distal radial double-column die-punch fractures. The evaluation results are shown in Table 6.

[0066] Table 6 Wrist joint function evaluation of the two groups of patients one year after surgery

[0067]

[0068] As can be seen from Table 6, among the 60 patients included in the study, 35 cases were excellent, 15 cases were good, 10 cases were fair, and 0 cases were poor, with an overall excellent and good rate of 83.33%; among them, the control group had 15 cases of excellent, 8 cases of good, 7 cases of fair, and 0 cases of poor, with an excellent and good rate of 76.67%; the experimental group had 20 cases of excellent, 7 cases of good, 3 cases of fair, and 0 cases of poor, with an excellent and good rate of 90%, which was better than the control group.

Claims

1. A She medicine prescription for reducing swelling and relieving pain used after fracture surgery, characterized in that: The raw materials include, by weight: 14-16 parts of red fennel root, 8-10 parts of Rhizoma Dioscoreae, 14-16 parts of elderberry, 14-16 parts of snake grape root, 14-16 parts of Aralia oleifera root, 14-16 parts of Prunus armeniaca root, 14-16 parts of Gingerbread, 14-16 parts of Radix Angelicae Pubescentis, 8-10 parts of Lily of the Valley root, 8-10 parts of Morus alba root, and 0.5-2 parts of borneol.

2. The She medicine swelling and pain relief prescription for use after fracture surgery as claimed in claim 1, characterized in that: The raw material composition includes, by weight: 15 parts of red fennel root, 9 parts of Rhizoma Dioscoreae, 15 parts of elderberry, 15 parts of ampelopsis root, 15 parts of aralia root, 15 parts of white peach root, 15 parts of ginger, 15 parts of ground radix, 9 parts of golden needle root, 9 parts of Morus alba root, and 1 part of borneol.

3. The method for preparing the She medicine swelling and analgesia prescription for use after fracture surgery as claimed in claim 1 or 2, characterized in that: include: (1) Grinding each raw material into powder and mixing according to a preset mass ratio; (2) Add rice wine and mix into a paste.

4. The method for preparing the She medicine swelling and analgesia prescription for use after fracture surgery as claimed in claim 1 or 2, characterized in that: include: (1) Mixing and grinding the raw materials into powder according to the preset weight ratio; (2) Add rice wine and mix into a paste.

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