Traditional Chinese medicine preparation for treating children with autism spectrum disorder and preparation method of traditional Chinese medicine preparation

Abstract

The invention discloses a traditional Chinese medicine preparation for treating autism spectrum disorder children and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material medicines: gastrodia elata, fructus alpiniae oxyphyllae, semen boitae, angelica sinensis, astragalus membranaceus, salvia miltiorrhiza, poria cocos, ligusticum wallichii, moutan bark, Chinese yam, bighead atractylodes rhizome, radix bupleuri, radix rehmanniae recen, rhizoma anemarrhenae, elecampane, polygala tenuifolia, agastache rugosus, hawthorn, schisandra chinensis, rhizoma acori graminei, rhizoma polygonati, cimicifugae foetidae, lucid ganoderma, peach kernel, safflower carthamus, sandalwood, pseudo-ginseng, honey-fried licorice root and stevia rebaudian. The formula aims to nourish the brain, increase blood and oxygen supply of the brain, enhance memory, improve thinking ability and improve language expression ability. The traditional Chinese medicine composition is capable of improving attention, relieving hyperactivity, improving nutrition digestion and absorption, enhancing immunity, relieving tension and dysphoria states, relieving self-malaria (malaria) behaviors, and further reducing spasm and convulsion caused by behavior stimulation.

Description

Technical Field

[0001] The present invention relates to a Chinese medicine preparation and a preparation method thereof, in particular to a Chinese medicine preparation for treating children with autism spectrum disorders and a preparation method thereof. Background Art

[0002] Autism spectrum disorder, also known as autism spectrum disorder, is a medical term for a pervasive developmental disorder that is now mostly used for children. Its symptoms include abnormal language skills, abnormal communication skills, narrow interests, and fixed behavior patterns.

[0003] At present, the incidence of autism spectrum disorder is increasing year by year. The prevalence of autism spectrum disorder in China is similar to that in other countries in the world, about 1%. It is generally concentrated in children aged 0 to 14 years old. It is currently classified as a patient with developmental disorders caused by nervous system disorders. Autism spectrum disorder often occurs before the age of 3, and is mainly manifested by intellectual retardation, accompanied by delayed speech development, poor learning ability, inability to express one's wishes and feelings, social barriers, and unwillingness to interact with others.

[0004] Autism spectrum disorder has many hazards. Children with autism spectrum disorder cannot live a normal life, cannot integrate well into society, and cannot participate in normal work, study and life. Autism spectrum disorder is a kind of disability. On the one hand, it harms the child, and on the other hand, it harms the family and society. Children with autism spectrum disorder have abnormal neurodevelopment and mental emotions, which will lead to a series of social hazards, endangering the family, individuals and society. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a Chinese medicine preparation for treating children with autism spectrum disorders and a preparation method thereof, which comprises the following technical solutions:

[0006] A traditional Chinese medicine preparation for treating children with autism spectrum disorders, comprising the following raw materials: Gastrodia elata, Alpinia oxyphylla, Platycladus orientalis, Angelica sinensis, Astragalus membranaceus, Salvia miltiorrhiza, Poria cocos, Ligusticum chuanxiong, Paeonia suffruticosa, Dioscorea opposita, Atractylodes macrocephala, Bupleurum chinense, Rehmannia root, Anemarrhena asphodeloides, Costusroot, Polygala tenuifolia, Patchouli, Crataegus pinnatifida, Schisandra chinensis, Acorus calamus, Polygonatum sibiricum, Cimicifuga heracleifolia, Ganoderma lucidum, Peach kernel, Safflower, Santalum album, Panax notoginseng, Radix glycyrrhizae, and Stevia leaf.

[0007] Further, the ratio of each raw material medicine is as follows: Gastrodia elata 20-50g, Alpinia oxyphylla 20-50g, Platycladus orientalis 20-50g, Angelica sinensis 10-55g, Astragalus membranaceus 15-60g, Salvia miltiorrhiza 15-25g, Poria 8-15g, Chuanxiong 20-40g, Paeonia suffruticosa 15-25g, Dioscorea opposita 25-35g, Atractylodes macrocephala 15-25g, Bupleurum 8-15g, Rehmannia root 9-18g, Anemarrhena asphodeloides 35g ~55g, costusroot 20~50g, polygala 40~70g, patchouli 8~15g, hawthorn 23~45g, schisandra 35~55g, calamus 45~75g, polygonatum 35~55g, cimicifuga 12~25g, ganoderma 45~75g, peach kernel 12~25g, safflower 20~40g, sandalwood 35~65g, notoginseng 20~40g, roasted licorice 20~40g, stevia leaf 1~5g

[0008] Preferably, it is composed of or made of the following raw materials: calculated per 1000g, the content of its components is 60g of Gastrodia elata, 60g of Alpinia oxyphylla, 60g of Platycladus orientalis, 45g of Angelica sinensis, 50g of Astragalus, 18g of Salvia miltiorrhiza, 12g of Poria, 30g of Ligusticum chuanxiong, 18g of Moutan bark, 30g of Dioscorea opposita, 18g of Atractylodes macrocephala, 12g of Bupleurum chinense, 9g of Rehmannia glutinosa, 48g of Anemarrhena asphodeloides, 30g of Costusroot, 60g of Polygala tenuifolia, 12g of Patchouli, 35g of Crataegus pinnatifida, 48g of Schisandra chinensis, 60g of Acorus calamus, 48g of Polygonatum sibiricum, 18g of Cimicifuga heracleifolia, 60g of Ganoderma lucidum, 18g of Peach Kernel, 30g of Carthamus tinctorius, 48g of Santalum album, 30g of Panax notoginseng, 30g of Radix Glycyrrhizae Preparata, and 3g of Stevia leaf.

[0009] The present invention also relates to a method for preparing a Chinese medicine preparation for treating children with autism spectrum disorders, which is a method for preparing the above-mentioned components, and the specific steps are as follows:

[0010] S1. Wash the herbs according to the proportion, soak them in cold water for 2 hours, and boil them. Boil the herbs in a decoction bucket over high heat, turn to 70 degrees, keep warm for 12 hours, and then turn off the heat.

[0011] S2, after cooling, filter out the liquid medicine, remove the remaining medicine residue with a dehydrator, mix the two liquid medicines and concentrate them to 20:1 to make a concentrated solution;

[0012] S3, weigh the original medicinal materials according to the proportion, wash and dry them, crush them into 100-mesh raw medicinal powder, mix and stir the raw medicinal powder and concentrated solution in a ratio of 1:5, and then granulate or cut them into pieces and dry them;

[0013] S4. After drying, crush to 120 mesh for later use. After sterilization, make into tablets, capsules or granules according to the situation.

[0014] The effects of each component in this recipe are as follows:

[0015] Gastrodia elata

[0016] Calms wind and stops convulsions, calms liver yang, dispels wind and dredges meridians.

[0017] 1. Liver wind movement, convulsions and epilepsy. This product mainly enters the liver meridian, has the function of calming wind and stopping convulsions, and has a sweet taste and moist texture, and has a mild medicinal property. Therefore, it can be used to treat liver wind movement, convulsions and epilepsy caused by various causes, regardless of cold, heat, deficiency or excess, and can be used in combination.

[0018] 2. Dizziness and headache: This product can calm liver wind and calm liver yang, and is the key medicine for treating dizziness and headache. It can be used regardless of deficiency or excess syndrome with different compatibility.

[0019] 3. Limb numbness, limb paralysis, rheumatic pain. This product can dispel external wind, dredge meridians and relieve pain. It is used to treat limb paralysis, tendon and bone pain caused by stroke; women's rheumatic arthritis, limb paralysis; rheumatic pain, joint flexion and extension problems, etc.

[0020] Pharmacological effects: Gastrodia elata water, alcohol extracts and different preparations can significantly reduce the spontaneous activities of mice, prolong the sleep time of mice induced by sodium barbital and sodium cyclohexene barbital, inhibit or shorten the onset of experimental epilepsy, reduce the resistance of peripheral blood vessels, cerebral blood vessels and coronary blood vessels, and have anti-hypertensive, heart rate slowing and analgesic and anti-inflammatory effects. Gastrodia elata polysaccharide has immune activity. Chemical composition: This product contains gastrodin, gastrodin aglycone, β-sitosterol, carrot glycoside, citric acid, monomethyl ester, palmitic acid, succinic acid and sucrose, etc.; it also contains gastrodia elata polysaccharide, vitamin A, various amino acids, trace alkaloids, and various trace elements, such as chromium, manganese, iron, cobalt, nickel, copper, zinc, etc.

[0021] Alpinia oxyphylla

[0022] Warms the spleen, stops diarrhea, and increases salivation; warms the kidneys, reduces urine, and consolidates semen.

[0023] It is mainly used to treat spleen and stomach deficiency and cold, vomiting, diarrhea, cold pain in the abdomen, excessive salivation, enuresis due to kidney deficiency, frequent urination, spermatorrhea, and leukorrhea.

[0024] Pharmacological effects: 1. Effects on the cardiovascular system; 2. Anti-gastric damage effects; 3. Other effects: inhibit the action of prostaglandins and increase peripheral blood leukocytes.

[0025] Bai Ziren

[0026] Platycodon grandiflorum has the effects of nourishing the heart and calming the mind, moistening the intestines and relieving constipation, and stopping sweating. It is used for yin-blood deficiency, insomnia due to deficiency, palpitations, constipation due to dry intestines, and night sweats due to yin deficiency.

[0027] Modern research shows that cypress seeds have multiple pharmacological effects such as prolonging sleep, improving memory, and restoring physical strength.

[0028] Angelica

[0029] It is warm in nature, sweet and pungent in taste. It enters the heart, liver and spleen meridians. It nourishes and regulates blood, regulates menstruation and relieves pain, moisturizes and lubricates the intestines. It treats irregular menstruation, amenorrhea and abdominal pain, accumulation of masses, metrorrhagia; headache due to blood deficiency, dizziness, paralysis; constipation due to dry intestines, heaviness after dysentery; carbuncle, ulcer, and injuries from falls.

[0030] 1. It can significantly promote the body's hematopoietic function and increase the content of red blood cells, white blood cells and hemoglobin; 2. It can regulate blood lipids, inhibit platelet aggregation, resist thrombosis, and regulate blood lipids;

[0031] 3. Lower blood pressure, resist myocardial ischemia and arrhythmia, dilate blood vessels and lower blood pressure;

[0032] 4. Enhance immunity, enhance immunity, anti-inflammation, protect liver, anti-radiation, anti-oxidation and scavenge free radicals, etc. In addition, it can also regulate uterine smooth muscle.

[0033] Astragalus

[0034] Sweet in taste and slightly warm in nature. Enters the lung, spleen, liver, and kidney meridians. It replenishes and strengthens the exterior, supports sores and promotes tissue regeneration. It is mainly used to treat spontaneous sweating due to physical weakness, chronic diarrhea, rectal prolapse, uterine prolapse, chronic nephritis, physical weakness and edema, chronic ulcers, and sores that do not heal for a long time. Raw Astragalus has the effects of invigorating qi and strengthening the exterior, promoting diuresis and reducing swelling, detoxifying, and promoting tissue regeneration. It is suitable for spontaneous sweating, night sweats, blood stasis, edema, carbuncle that does not ulcerate or ulcers that do not heal for a long time. Honey-roasted Astragalus has the effects of invigorating qi, nourishing blood, and benefiting the middle, and is suitable for internal injuries, fatigue, spleen deficiency diarrhea, qi deficiency, blood deficiency, and qi deficiency.

[0035] Modern medicine has proven that astragalus has the effects of reducing blood viscosity, reducing thrombosis, lowering blood pressure, protecting the heart, bidirectionally regulating blood sugar, resisting free radical damage, anti-aging, anti-hypoxia, anti-tumor, and enhancing the body's immunity. It can be used to treat heart disease, hypertension, diabetes and other diseases. Astragalus can also dilate blood vessels, improve skin blood circulation and nutritional status, so it is effective for chronic ulcers that have not healed for a long time. It can also eliminate proteinuria in patients with nephritis, protect the liver, and prevent the reduction of liver glycogen.

[0036] Salvia miltiorrhiza

[0037] Salvia miltiorrhiza has the functions of promoting blood circulation and removing blood stasis, promoting menstruation and relieving pain, clearing the heart and relieving restlessness, cooling blood and eliminating carbuncle.

[0038] Danshen is used for chest pain, heart pain, epigastric and flank pain, accumulation of masses, pain due to heat, restlessness and insomnia, irregular menstruation, dysmenorrhea and amenorrhea, and swelling and pain of sores.

[0039] Salvia miltiorrhiza has many pharmacological effects, including anti-coagulation, anti-thrombosis, improvement of microcirculation, improvement of blood rheology, anti-myocardial ischemia and anti-cerebral ischemia, antioxidant, anti-tumor, anti-inflammatory, anti-fibrosis, and cholesterol-lowering.

[0040] Poria: Poria is sweet, light and neutral in nature. It can dissipate dampness and promote diuresis; strengthen the spleen and stomach; and calm the mind and nerves. It is mainly used to treat urinary problems; edema; phlegm and cough; vomiting; spleen deficiency and poor appetite; diarrhea; palpitations and restlessness; insomnia and forgetfulness; and leukorrhea.

[0041] 1. Diuresis and swelling reduction. Poria has many functions such as diuresis, swelling reduction, semen consolidation, tranquilizing the mind, and strengthening the spleen and stomach.

[0042] 2. Improve human immunity. Poria cocos can also improve human immune function and has the effect of preventing and fighting cancer.

[0043] 3. Lowering blood pressure: Poria can reduce the contraction amplitude of smooth muscle and lower its tension. Poria can affect the body's metabolism, regulate the balance of electrolytes, lower blood sugar, and inhibit the permeability of capillaries.

[0044] Chuanxiong

[0045] It is used for chest and flank pain, rheumatic pain, mass lumps, swelling and pain of sores, pain from falls and injuries, irregular menstruation, amenorrhea, dysmenorrhea, and postpartum pain and blood stasis.

[0046] Chuanxiong is pungent, warming and unblocking. It has the function of promoting blood circulation and removing blood stasis. It has a wide range of effects and is suitable for various diseases caused by blood stasis. It is especially important for regulating menstruation in gynecology. It is often used with Chinese angelica to treat irregular menstruation, amenorrhea and dysmenorrhea; it can be used with Bupleurum and Cyperus to treat chest and flank pain; it can be used with Notopterygium and Angelicae Pubescentis to treat rheumatic pain; it can be used with Trillium and Curcuma to treat lumps and masses; it can be used with frankincense and myrrh to treat sores, swelling and pain, and injuries from falls.

[0047] It is used for cold headache, hemiplegia and other symptoms. Chuanxiong is pungent and fragrant, and can ascend to the top of the head and eyes, and has the effect of dispelling wind and relieving pain. It is an important medicine for treating headache caused by wind. It can be used with asarum and angelica, or it can be appropriately matched according to which meridian the headache belongs to. For headache caused by wind evil, it can be used with schizonepeta, saposhnikovia, and angelica root to treat cold headache caused by wind and cold; it can be matched with chrysanthemum and silkworm to treat wind-heat headache.

[0048] In addition, this product has been commonly used clinically in recent years to treat angina pectoris caused by coronary heart disease.

[0049] Peony bark

[0050] Clears heat and cools blood, activates blood circulation and removes stasis. Peony bark is used for heat entering the blood, fever and toxicity causing spots, vomiting blood and bleeding, night heat and morning coolness, no sweat and bone steaming, amenorrhea and dysmenorrhea, pain from falls and injuries, carbuncle, swelling and sore.

[0051] This product has multiple pharmacological effects such as antibacterial, anti-inflammatory, analgesic, anti-tumor and liver protection.

[0052] Yam

[0053] The main effects of yam are to nourish qi and yin, tonify the spleen, lungs and kidneys, astringe semen and stop leucorrhea. It is used to treat spleen deficiency, poor appetite, loose stools, excessive leucorrhea, lung deficiency, wheezing and coughing, kidney deficiency, spermatorrhea, leucorrhea, frequent urination, and deficiency heat and thirst.

[0054] Modern research shows that yam decoction has preventive and therapeutic effects on spleen deficiency animal models, can inhibit gastric emptying and intestinal propulsion, antagonize the tonic contraction of isolated ileum, enhance the absorption function of small intestine, help digestion, and protect gastric mucosal damage. Yam decoction and yam polysaccharide can lower blood sugar. Yam polysaccharide can improve nonspecific immune function, specific cellular immunity and humoral immunity. Yam polysaccharide, total flavonoids and yam dilute alcohol extract have antioxidant and anti-aging effects. Allantoin in yam has anti-irritation, anesthetic analgesic and anti-inflammatory and antibacterial effects. In addition, yam has lipid-lowering and anti-tumor effects.

[0055] Atractylodes macrocephala

[0056] Atractylodes macrocephala has the functions of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, stopping sweating, and calming the fetus. Atractylodes macrocephala is used for spleen deficiency, poor appetite, abdominal distension and diarrhea, phlegm and fluid, dizziness and palpitations, edema, spontaneous sweating, and restless fetus. Spleen qi deficiency, spleen and stomach qi deficiency, poor appetite, clear stools, weak limbs and fatigue, etc.

[0057] This product has multiple pharmacological effects, including anti-digestive ulcer, promoting gastrointestinal motility, protecting the liver, promoting bile secretion, enhancing the body's immune function, anti-oxidation, anti-tumor, lowering blood sugar, anti-coagulation, and antibacterial.

[0058] The main effects of yam are to nourish qi and yin, tonify the spleen, lungs and kidneys, astringe semen and stop leucorrhea. It is used to treat spleen deficiency, poor appetite, loose stools, excessive leucorrhea, lung deficiency, wheezing and coughing, kidney deficiency, spermatorrhea, leucorrhea, frequent urination, and deficiency heat and thirst.

[0059] Bupleurum

[0060] Bupleurum has the effects of dispersing fever, relieving liver depression, and raising Yang Qi. Bupleurum is used for colds and fever, alternating cold and heat, chest and flank pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0061] This product has multiple pharmacological effects such as antipyretic, anti-inflammatory, anti-pathogenic microorganism, anticonvulsant, lipid-lowering, liver protection, choleretic, inhibition of gastric acid secretion, anti-ulcer, anti-tumor and immune regulation.

[0062] Rehmannia glutinosa

[0063] Rehmannia root has the functions of clearing away heat, cooling blood, nourishing yin and promoting body fluid. It is used for heat entering the blood, fever toxicity causing rash, vomiting blood and epistaxis, yin damage caused by febrile disease, red tongue and thirst, constipation caused by body fluid damage, fever caused by yin deficiency, bone steaming and fatigue fever, and internal heat and thirst.

[0064] It mainly contains catalpol, dihydroxycatalpol, acetyl catalpol, rehmannia glycoside, aucubin, miltidyl glycoside, monomiltidyl glycoside, dehydroxygardyl glycoside, scutellaria glycoside and other cyclic terpene glycosides and phenylethanoid glycosides such as verbascoside. In addition, it also contains β-sitosterol, various amino acids and sugars.

[0065] The decoction of Rehmannia glutinosa can inhibit the excitement of β-adrenergic receptors caused by large doses of thyroxine, enhance the function of the M-basic receptor-cGMP system, increase the level of cAMP content, and significantly antagonize the adrenal cortex atrophy and functional decline caused by dexamethasone, and increase the plasma corticosterone level.

[0066] Rehmannia glutinosa extract, alcohol extract and rehmannia glycosides all have certain blood sugar-lowering effects.

[0067] Rehmannia glycosides and Rehmannia oligosaccharides can enhance humoral and cellular immune function.

[0068] In addition, it has the effects of anti-gastric ulcer, promoting gastric ulceration, stopping bleeding, lowering blood pressure, anti-osteoporosis, and protecting against cerebral ischemia, brain damage and neurasthenia.

[0069] Anemarrhena

[0070] Zhimu has the effects of clearing away heat and purging fire, nourishing yin and moistening dryness. Zhimu is used for exogenous febrile diseases, high fever and thirst, lung heat and dry cough, bone steaming and hot flashes, internal heat and thirst, and dry intestines and constipation.

[0071] It has multiple pharmacological effects such as anti-pathogenic microorganisms, antipyretic, anti-inflammatory, hypoglycemic, anti-stress gastric ulcer, anti-tumor, and improvement of learning and memory.

[0072] Woody

[0073] Muxiang has the effects of promoting qi and relieving pain, strengthening the spleen and promoting digestion. Muxiang is used for chest and flank, abdominal distension and pain, heaviness after diarrhea, indigestion, and loss of appetite.

[0074] This product has multiple pharmacological effects, including regulating gastrointestinal motility, promoting secretion of digestive juice, resisting peptic ulcer, promoting gallbladder contraction, promoting choleresis, relaxing tracheal smooth muscle, analgesia, antibacterial, lowering blood pressure, diuresis and promoting fibrinolysis.

[0075] Polygala

[0076] Polygala has the effects of calming the mind, improving intelligence, connecting the heart and kidneys, removing phlegm and reducing swelling.

[0077] Polygala is used to treat insomnia, dreaminess, forgetfulness, palpitations, confusion, coughing up phlegm, sores, swelling and pus, and breast swelling and pain caused by disharmony between the heart and kidney.

[0078] Processed Polygala can not only alleviate dryness, but also eliminate numbness and prevent throat irritation, mainly for calming the mind and improving intelligence. Honey Polygala can enhance the effect of expectoration and cough relief, and is mostly used for cough, phlegm, and difficulty in coughing up.

[0079] This product has multiple pharmacological effects such as sedation and hypnosis, anti-depression, improvement of learning and memory, and antitussive and expectorant.

[0080] Patchouli

[0081] Patchouli has the effects of eliminating dampness and invigorating the spleen, eliminating filth and harmonizing the stomach, relieving heat and releasing exterior.

[0082] It is used for symptoms such as dampness blocking the spleen and stomach, abdominal distension, the initial onset of damp-heat, vomiting, diarrhea, summer-heat, fever and chills, fever and chills, and chest and abdominal fullness.

[0083] hawthorn

[0084] Hawthorn can invigorate the stomach and aid digestion, promote qi and relieve blood stasis, resolve turbidity and reduce fat.

[0085] Hawthorn is rich in vitamin C, carbohydrates, multiple minerals, carotene, etc. It has the effects of invigorating the stomach and digestion, promoting qi and relieving blood stasis, clearing turbidity and reducing fat.

[0086] Schisandra chinensis

[0087] Schisandra chinensis has the functions of astringing, invigorating Qi and promoting body fluid, nourishing the kidney and calming the mind.

[0088] Schisandra chinensis is used for long-term cough, weak asthma, nocturnal emission, spermatorrhea, enuresis and frequent urination, long-term diarrhea, spontaneous sweating and night sweats, thirst due to loss of body fluid, internal heat and thirst, palpitations and insomnia.

[0089] This product has multiple pharmacological effects such as liver protection, immune enhancement, sedation, anti-depression, antioxidant, anti-tumor, and myocardial protection.

[0090] Acorus

[0091] Acorus calamus has the effects of opening the orifices and eliminating phlegm, refreshing the mind and improving intelligence, and removing dampness and stimulating appetite.

[0092] Acorus calamus is used for coma, epilepsy, forgetfulness, insomnia, tinnitus, deafness, abdominal distension without hunger, and dysentery with lockjaw.

[0093] This product has multiple pharmacological effects such as sedation, anticonvulsant, antidepressant, improvement of learning and memory, resistance to cardiac and cerebral ischemic damage, regulation of gastrointestinal motility, antiasthmatic, expectorant, and antitussive.

[0094] Polygonatum

[0095] Polygonatum sibiricum has the effects of replenishing qi and nourishing yin, strengthening the spleen, moistening the lungs and benefiting the kidneys.

[0096] Polygonatum sibiricum is used for spleen and stomach qi deficiency, fatigue, insufficient stomach yin, dry mouth and poor appetite, lung deficiency and dry cough, cough with blood due to fatigue, insufficient essence and blood, soreness of the waist and knees, premature graying of hair, internal heat and thirst.

[0097] This product has multiple pharmacological effects such as improving immunity, resisting fatigue, improving memory, and anti-oxidation.

[0098] Cimicifuga

[0099] Cimicifuga has the effects of dispelling wind and clearing away heat, detoxifying, and raising Yang Qi.

[0100] Cimicifuga is used for wind-heat headache, toothache, mouth ulcers, sore throat, measles that do not break out, yang poison spots, rectal prolapse, and uterine prolapse.

[0101] Lingzhi

[0102] Lingzhi has the functions of replenishing qi and calming the mind, relieving cough and relieving asthma. It is used for restlessness, insomnia, palpitations, lung deficiency, cough and asthma, shortness of breath due to consumptive disease, and loss of appetite.

[0103] Ganoderma lucidum polysaccharide has a wide range of immunomodulatory activities and can enhance the body's immune activity.

[0104] The triterpenoid compounds isolated from Ganoderma lucidum fruiting bodies, Ganoderma lucidum polysaccharides, and Ganoderma lucidum spores all have anti-tumor effects.

[0105] The proteoglycans in Ganoderma lucidum have antiviral activity, and acid-bound Ganoderma lucidum polysaccharides (APBP) have activity against herpes simplex virus (HSV)-1 and HSV-2. Ganoderma lucidum triterpenoid compounds can also resist HIV.

[0106] The phenolic compounds and Ganoderma lucidum aminopolysaccharide G009 obtained by methanol extraction of Ganoderma lucidum have antioxidant and anti-aging effects.

[0107] Ganoderma lucidum polysaccharide can protect the liver and improve the ability to tolerate hypoxia.

[0108] In addition, Ganoderma lucidum can reduce blood viscosity, increase superficial muscle contractility, increase coronary blood flow and cardiac output, and improve heart rhythm; it can also resist the damage to the body by radiation and toxic chemicals, has sedative and analgesic effects, prolong sleep time, improve sleep quality, and can relieve asthma, relieve cough, eliminate phlegm and treat chronic bronchitis.

[0109] Peach Kernel

[0110] Peach kernel contains amygdalin, 24-methylenecycloartanol, prussin, β-sitosterol, campesterol and their glucosides, as well as chlorogenic acid, 3-caffeoylquinic acid, amygdalin, volatile oil and fatty oil. The decoction has anti-inflammatory effect, the fatty oil contained has the effect of moistening the intestines and relieving constipation, and the extract has the effect of dilating blood vessels. The alcohol extract has the effect of inhibiting blood coagulation. Peach kernel can also be anti-allergic, antitussive, analgesic, promote uterine contraction and stop bleeding in primiparas.

[0111] Rich in fat, it maintains body temperature and protects internal organs; provides essential fatty acids; promotes the absorption of these fat-soluble vitamins; and increases satiety.

[0112] Rich in carbohydrates, an important substance that constitutes the body; stores and provides heat energy; is the energy necessary to maintain brain function; regulates fat metabolism; provides dietary fiber; saves protein; detoxifies; and enhances intestinal function.

[0113] Rich in cellulose, it makes people feel full and helps lose weight. It can stimulate the gastrointestinal tract after eating and can prevent and treat diseases such as constipation and hemorrhoids.

[0114] 1. Laxative: Cellulose can promote the peristalsis of the intestinal wall, help digestion, and prevent dry stool. It can lubricate the intestines and stimulate defecation. It keeps the stool in the intestine moist to facilitate defecation. B vitamins can promote the secretion of digestive juices, maintain and promote intestinal peristalsis, and facilitate defecation.

[0115] 2. Regulate menstruation: relieve dysmenorrhea or back pain during menstruation. Regulate long (short) or scanty (excessive) menstruation.

[0116] 3. Hemostasis: It contains a lot of colloid, produces platelets, and has hemostasis effect. It is suitable for patients with bleeding diseases and women with menorrhagia and hemorrhage.

[0117] 4. Replenish energy: Contains carbohydrates and sugars, which can quickly provide energy to the body.

[0118] Peach kernel is sweet and bitter in nature, and enters the lung, liver, and large intestine meridians. It has the effects of breaking blood, removing blood stasis, moistening dryness and lubricating the intestines. It can treat amenorrhea, dysmenorrhea, lumps and masses, bruises, and intestinal dryness and constipation.

[0119] safflower

[0120] Warm in nature, pungent in taste. Mainly used to promote blood circulation, relieve blood stasis and relieve pain. Used for amenorrhea, dysmenorrhea, lochia retention, lumps and bruises. Ancient people often add a handful of safflower when blood is in the body: wrap it in gauze and boil it. It can be used to soak feet twice a day. It is suitable for various varicose veins, peripheral neuritis, and blood circulation.

[0121] sandalwood

[0122] Sandalwood has the effects of promoting qi and warming the middle, stimulating appetite and relieving pain.

[0123] Sandalwood is used to treat cold stagnation and qi stagnation, chest discomfort, chest pain, heart pain, abdominal pain, vomiting and loss of appetite.

[0124] α-Sandalwood and β-Sandalwood in sandalwood have similar neuropharmacological activity to chlorpromazine and have a central sedative effect on mice. Sandalwood volatile oil has an inhibitory effect on intestinal hypermotility in mice; sandalwood oil has a diuretic effect; and has an inhibitory effect on Shigella dysenteriae and Mycobacterium tuberculosis. Panax notoginseng

[0126] The main effects of Panax notoginseng are dispersing blood stasis, stopping bleeding, reducing swelling and relieving pain.

[0127] Panax notoginseng is used for hemoptysis, hematemesis, epistaxis, blood in the stool, metrorrhagia, bleeding from trauma, stabbing pain in the chest and abdomen, and swelling and pain from falls. Raw Panax notoginseng is mainly used to disperse blood stasis and stop bleeding, while cooked Panax notoginseng is mainly used to replenish blood and qi.

[0128] Modern research shows that Panax notoginseng mainly contains ginsenosides Rb1, Rd, Re, Rg1, Rg2, Rh1, notoginsenosides R1, R2, R3, R4, R6, R7, aescin, notoginsenosides A, B, C, D, E, G, H, I, J and other tetracyclic triterpenoid components. It also contains notoginseng, quercetin and polysaccharides.

[0129] It has the effects of anti-thrombosis, anti-cerebral ischemia, anti-myocardial damage, anti-arrhythmia, anti-inflammatory, improving learning and memory, and anti-fatigue.

[0130] Roasted Licorice

[0131] Roasted licorice has the effects of nourishing the spleen and stomach, replenishing qi and restoring the pulse.

[0132] Roasted licorice is used for weak spleen and stomach, fatigue, palpitations, and irregular pulse.

[0133] It has multiple pharmacological effects, including anti-peptic ulcer, liver protection, antispasmodic, antiarrhythmic, antitussive and expectorant, detoxification, anti-inflammatory, antibacterial, antiviral, anti-allergic, adrenocortical hormone-like effects, as well as anti-tumor and anti-mutation effects.

[0134] Stevia Leaf

[0135] Stevia leaf is a perennial herbaceous plant of the Asteraceae family and the genus Stevia. It can be used as a traditional Chinese medicine. It is sweet and neutral in nature. It enters the lung and stomach meridians. It can also be taken as a tea. It tastes sweet and palatable. It has the effect of assisting in lowering blood pressure and blood sugar.

[0136] The present invention adopts the above technical solution to achieve the following beneficial effects:

[0137] This prescription aims to nourish the brain, increase blood and oxygen supply to the brain, enhance memory, improve thinking ability, improve language expression ability, improve attention, reduce hyperactivity, improve nutrient digestion and absorption, enhance immunity, relieve tension and irritability, reduce self-abuse (abuse of others), and thus reduce spasms and convulsions caused by behavioral stimulation.

[0138] This prescription is mainly suitable for children with autism spectrum disorders, and is used to treat behaviors such as attention distraction, hyperactivity, delayed language development, delayed brain development, and poor nutrient digestion and absorption. DETAILED DESCRIPTION

[0139] The technical solution of the present invention is demonstrated below in conjunction with the embodiments.

[0140] A traditional Chinese medicine preparation for treating children with autism spectrum disorder, the contents of its components are as follows per 1000g: 60g of Gastrodia elata, 60g of Alpinia oxyphylla, 60g of Platycladus orientalis, 45g of Angelica sinensis, 50g of Astragalus, 18g of Salvia miltiorrhiza, 12g of Poria, 30g of Ligusticum chuanxiong, 18g of Paeonia suffruticosa, 30g of Dioscorea opposita, 18g of Atractylodes macrocephala, 12g of Bupleurum chinense, 9g of Rehmannia glutinosa, 48g of Anemarrhena asphodeloides, 30g of Costusroot, 60g of Polygala tenuifolia, 12g of Patchouli, 35g of Crataegus pinnatifida, 48g of Schisandra chinensis, 60g of Acorus calamus, 48g of Polygonatum sibiricum, 18g of Cimicifuga heracleifolia, 60g of Ganoderma lucidum, 18g of Peach Kernel, 30g of Carthamus tinctorius, 48g of Santalum album, 30g of Panax notoginseng, 30g of Radix Glycyrrhizae Preparata, and 3g of Stevia leaf.

[0141] The specific steps for preparing the above components are as follows:

[0142] S1. Wash the herbs according to the proportion, soak them in cold water for 2 hours, and boil them. Boil the herbs in a decoction bucket over high heat, turn to 70 degrees, keep warm for 12 hours, and then turn off the heat.

[0143] S2, after cooling, filter out the liquid medicine, remove the remaining medicine residue with a dehydrator, mix the two liquid medicines and concentrate them to 20:1 to make a concentrated solution;

[0144] S3, weigh the original medicinal materials according to the proportion, wash and dry them, crush them into 100-mesh raw medicinal powder, mix and stir the raw medicinal powder and concentrated solution in a ratio of 1:5, and then granulate or cut them into pieces and dry them;

[0145] S4. After drying, crush to 120 mesh for later use. After sterilization, make into tablets, capsules or granules according to the situation.

[0146] Typical cases:

[0147] Case 1: Chen, female, 5 years old, address: Zhanhe District, Pingdingshan City, Henan Province

[0148] The parents described their child's first attack at the age of one year and three months. When the attack occurred, the child stared and twitched in pain. There was no response to calling, and the attack lasted about one minute. After the attack, the whole body became limp and the spirit was exhausted. After that, the child had an attack every 7-12 days on average, and the shortest interval between attacks was 3 days. After that, the parents found that the child's language had degenerated, and his personality gradually became introverted, timid, and unwilling to communicate with others. After the first attack, the child sought medical treatment from many places, and all were treated for epilepsy.

[0149] Examination: The child is thin, with a sallow complexion, a pale tongue, thin, bitter and white tongue, and pale lower eyelids. He is timid, has a weak voice, and has no independent speech.

[0150] Diagnosis: Weak spleen and stomach, insufficient Qi and blood, insufficient blood and oxygen supply to the heart and brain.

[0151] The granules of the present invention are given for one month as a course of treatment (30 days). In the first month, the granules are taken four times a day, morning, noon, evening and before going to bed, 3g each time. Parents of the children are advised to give feedback in time.

[0152] First month feedback

[0153] Week 1: The child's appetite improves, food intake increases, and sleeps more soundly.

[0154] Week 2: One attack lasted about 20 seconds. After the attack, the mental state was better than before taking the medicine, and everything else was normal.

[0155] Week 3: No disease.

[0156] Week 4: One attack, same as week 2.

[0157] Second month, follow-up visit: complexion was rosier than before, tongue quality and tongue coating had improved, lower eyelids were still pale, timid behavior was alleviated, pronunciation had improved, and he could occasionally say a few words.

[0158] Continue to take the granules of the present invention, still four times a day, and ask his parents to gradually reduce the dosage of epilepsy drugs, and feedback the child's condition in time.

[0159] Feedback on the second course of treatment:

[0160] The patient has normal diet and sleep. The disease occurred once and was mild. The timid behavior has been significantly improved. He occasionally speaks 2-3 words on his own initiative when needed. The use of epilepsy medication has been gradually reduced. Everything else is normal.

[0161] The third course of treatment continued to take the instant granules of the present invention, still four times a day.

[0162] Feedback on the third course of treatment:

[0163] The child's diet, sleep and mental state were normal. His parents stopped taking epilepsy medication without authorization, and the child did not have any seizure. The child was able to simply follow instructions, but his language ability had not made much progress.

[0164] From the fourth to the sixth course of treatment, the dosage of the instant granules of the present invention is changed to 3 times a day, 3 g each time, divided into morning, noon and evening.

[0165] Feedback:

[0166] The child did not develop any disease, his language ability improved, and he could communicate and interact in a simple way. His parents enrolled him in painting and dance classes, taught him to ride a bike, and raised a small animal.

[0167] Seventh to ninth courses of treatment: still take the granules of the present invention three times a day, 3 g each time.

[0168] Feedback:

[0169] The child's language expression ability, behavior performance, and intelligence level are close to those of normal children of the same age. After communicating with his parents, the treatment was stopped and he was allowed to develop and grow naturally.

[0170] When visited again two years later, his parents said that their child had been enrolled in school normally and all indicators had reached the normal level for children of the same age.

[0171] Case 2: Ma, male, 9 years old. Address: Karamay, Xinjiang.

[0172] The child's parents described: The child is in the second grade of elementary school and has poor concentration and language expression ability. Because he often takes off his clothes in class, dismantles tables and chairs, and urinates and defecates in the classroom, the school requires his parents to accompany him and requires the child to drop out of school.

[0173] Examination showed that the child was obese, had a pale tongue, was distracted, had slow and incoherent speech, was easily agitated and irritable, and had a tendency to self-abuse. When excited and irritated, he would bite the back of his right hand (the location of the Hegu acupoint) vigorously. Due to the long-term stimulation of biting, a large area of ​​calluses had formed. His parents said that this behavior had been going on for several years.

[0174] Treatment: Give the capsule and granule of the present invention. Dosage: Capsules, three times a day, 2.5g (5 capsules) each time, 30 minutes before meals in the morning, afternoon and evening. Granules, once a day, 6g each time, 1 hour before bedtime. Parents are advised to avoid verbal and behavioral stimulation to the child.

[0175] In the first week of taking the preparation of the present invention, the child's mood was basically stable, and his diet and sleep were normal. He bit his hand once due to excitement, and there were no other changes.

[0176] In the second week, the preparation of the present invention was still taken according to the method of taking in the first week, and reading aloud for 30 minutes each in the morning and afternoon was added.

[0177] In the second week, the child's attention span improved significantly and he no longer showed excessive behavior such as biting his hands. His language expression ability also showed initial improvement.

[0178] In the third week, the preparation of the present invention was changed to capsule, 3 times a day, each time 2.5 g (5 capsules), divided into morning, noon and evening 30 minutes before meals, and the granules of the present invention were stopped. The reading time in the morning and afternoon was increased to 45 minutes (one class time) every day.

[0179] In the third week, the child did not show any extreme behavior of biting his hands, the calluses on his hands had softened, and his attention and language expression abilities had further improved.

[0180] After three weeks, the parents of the child had to go back to work because of the end of the holiday, so the parents were asked to continue taking the preparation of the present invention for the child for three months. After three months of follow-up, the child was able to attend classes normally, no more radical behavior, and the attention and language expression ability were close to normal children.

[0181] A follow-up visit one year later showed no significant differences in the various indicators of the children compared with normal children of the same age.

[0182] Case 3: Yang, male, 11 years old. Address: Jinan City, Shandong Province.

[0183] The child has normal physical development, dark complexion, pale tongue, white fur, dull eyes, his hands are constantly placed in front of his eyes, he keeps pinching and grasping, his legs keep moving back and forth in the room, he completely ignores calls from the outside world, and is completely immersed in his own world.

[0184] The child's mother described: When the child was 2 years old, she found that his language had regressed and was accompanied by strange movements. He was sensitive to sounds, would become frightened and irritable to unfamiliar sounds, and could not take care of himself.

[0185] The children were given the granules of the present invention, and the method of taking them was four times a day, 3 g each time, taken 30 minutes before breakfast, lunch and dinner and 1 hour before going to bed.

[0186] After taking the granules of the present invention for three months, the child's strange movements were alleviated, and his sensitivity to sound was close to that of a normal child. Under the guidance of his parents, he was able to complete urination and defecation. There was no change in his language expression ability.

[0187] After taking the granules of the present invention for six months, the patient's attention span was greatly improved, his strange movements were significantly alleviated and reduced, his language expression ability was slightly improved, and he could urinate and defecate independently.

[0188] After taking the granules of the present invention for 12 months, the patient's attention span has been greatly improved. The patient can sit for about 30 minutes to complete the training of picking up beans with chopsticks, and can complete simple instructions. The patient's language expression ability has been significantly improved, and the patient can basically take care of himself in daily life (washing face, brushing teeth, eating, defecation, etc.).

[0189] After taking the patented granules of the present invention for 18 months, the language expression ability can speak simple sentences (short sentences of 5-7 words), and other indicators have been significantly improved.

[0190] His parents sent the child to a private school (normal schools would not accept him).

[0191] During a follow-up visit six months later, the parents reported that the child was attending a private school and was doing well.

[0192] Case 4: Guo, male, 10 years old, address: Jingning County, Pingliang City, Gansu Province.

[0193] The child's parents describe: The child has a poor concentration and giggles for no apparent reason. He had epilepsy at the age of three and has been cured. He twitches unconsciously after falling asleep at night. He has to smell food before eating. He has language, low intelligence, is not sociable, likes to play by himself, and has the ability to express himself. He attends a special education school.

[0194] Treatment: Give the child the tablet of the present invention, four times a day, 2.5 g each time (5 tablets), divided into morning, noon, evening and 1 hour before bedtime.

[0195] After taking the tablets of the present invention for 20 days, the sleeping condition of the child was greatly improved, the twitching after falling asleep was reduced, the giggling behavior was reduced, the appetite was increased, and there were no other obvious changes.

[0196] After taking the tablets of the present invention for 2 months, the sleep condition has been close to normal, with occasional twitching after deep sleep, and the intelligence has improved to some extent, but there are no other obvious changes.

[0197] After taking the tablets of the present invention for 6 months, the patient's sleep condition was normal, he was stable after deep sleep, there was no twitching phenomenon, his intelligence was significantly improved, his attention was significantly improved, he occasionally smelled the food first, and his unsociable situation did not change.

[0198] After taking the tablets of the present invention for 8 months, the child learned to ride a bicycle and could wash small items such as socks under the guidance of his parents. Other symptoms were improved to varying degrees.

[0199] After taking the tablets of the present invention for 12 months, the child was able to write under the supervision of his parents and special education teachers, his interest in learning was enhanced, his asociality was greatly improved, and he liked to ask questions about unfamiliar things. Other changes were significant. His parents were asked to continue giving the child the tablets of the present invention.

[0200] After a follow-up visit one year later, all indicators continued to improve.

[0201] Case 5: Lin Jiahao, male, 4 years and 6 months old, address: Hanzhong City, Shaanxi Province.

[0202] The child first had the disease when he was 8 months old. During the attack, he had convulsions, stiff muscles, wide-open eyes, rapid breathing and breath holding, which lasted for about 1 minute. After the attack, the child was listless. The second attack occurred when he was 1 year and 4 months old, and the symptoms were the same as the first attack. After that, the attack was irregular and irregular every 3-5 days. After multiple attacks, the frequency of attacks shortened, with an average of 1-2 days, and the time of attacks was irregular and irregular. His parents found that the child's language, walking function and intelligence had deteriorated. He sought medical treatment from many places and was treated for epilepsy.

[0203] Check: the child has a dull expression, dull eyes, irritability, throwing things (all the items that can be moved are thrown on the ground), no language (can only make ah ah sounds), weak legs, unable to stand, relying on baby carriages to go out, unable to take care of themselves, wearing diapers all day, mental retardation, IQ equivalent to a 6-month-old baby. Give the child the granules of the present invention, taking method: 18g (6 bags) per day, disposable children's thermos cup, regardless of the number of times as water. And ask his parents to give the child extra meals at 10 am and 4 pm every day.

[0204] After taking the granules of the present invention for one month, the child's expression and eyesight improved, irritability improved slightly, and the disease became regular, with an attack once every two days, when getting up in the morning, and no other changes. Ask his parents to help the child exercise standing for 10 minutes every morning and afternoon.

[0205] After taking the granules of the present invention for 3 months, the child's facial expression and eyesight were significantly improved, and he occasionally threw things in a tantrum, but was able to stand by holding objects, and there were no other changes. His parents were asked to let the child practice walking.

[0206] After taking the granules of the present invention for 6 months, the child's expression and eyes were no different from those of normal children, and he no longer had irritability or littering behavior. He was able to walk with the help of objects. There were no other changes. His parents were asked to let the child practice squatting, add meals 2 hours before going to bed every night, and take 1.5g (1 / 2 bag) of the granules of the present invention 1 hour before going to bed.

[0207] After taking the granules of the present invention for 9 months, the child was able to walk, jump and squat normally. The disease occurred twice in 3 months, which was relatively mild and the language did not change. The parents were asked to let the child practice opening the mouth, gradually practice speaking, and help the child practice going to the toilet to urinate.

[0208] After taking the granules of the present invention for 12 months, the child has not been sick for 3 consecutive days, his intelligence has been significantly improved, he can make simple pronunciations, and he can go to the toilet to urinate and defecate under the instructions of his parents.

[0209] After taking the granules of the present invention for 18 months, the child had no disease for 9 consecutive months, could go to the toilet independently for defecation and urination, and could express the overlapping words of 2 characters in language. His parents decided to send the child to an early education class.

[0210] After taking the granules of the present invention for 24 months, the child has not been ill for 15 consecutive months, and except for insufficient language expression ability, he is no different from other children of the same age. His parents have sent the child to a normal kindergarten.

Claims

1. A Chinese medicine preparation for treating children with autism spectrum disorders, characterized in that: It contains the following raw materials: Gastrodia elata, Alpinia oxyphylla, Platycladus orientalis, Angelica sinensis, Astragalus membranaceus, Salvia miltiorrhiza, Poria cocos, Ligusticum chuanxiong, Paeonia suffruticosa, Dioscorea batatas, Atractylodes macrocephala, Bupleurum chinense, Rehmannia root, Anemarrhena asphodeloides, Costusroot, Polygala tenuifolia, Patchouli, Crataegus pinnatifida, Schisandra chinensis, Acorus calamus, Polygonatum sibiricum, Cimicifuga heracleifolia, Ganoderma lucidum, Peach kernel, Safflower, Santalum album, Panax notoginseng, Radix licorice, and Stevia leaf.

2. A Chinese medicine preparation for treating children with autism spectrum disorders according to claim 1, characterized in that: The ratio of each raw material is as follows: Gastrodia elata 20~50g, Alpinia oxyphylla 20~50g, Platycladus orientalis 20~50g, Angelica sinensis 10~55g, Astragalus membranaceus 15~60g, Salvia miltiorrhiza 15~25g, Poria 8~15g, Ligusticum chuanxiong 20~40g, Paeonia suffruticosa 15~25g, Dioscorea opposita 25~35g, Atractylodes macrocephala 15~25g, Bupleurum 8~15g, Rehmannia root 9~18g, Anemarrhena asphodeloides 35~55g g, costusroot 20~50g, polygala 40~70g, patchouli 8~15g, hawthorn 23~45g, schisandra 35~55g, calamus 45~75g, polygonatum 35~55g, cimicifuga 12~25g, ganoderma lucidum 45~75g, peach kernel 12~25g, safflower 20~40g, sandalwood 35~65g, panax notoginseng 20~40g, roasted licorice 20~40g, stevia leaf 1~5g.

3. A Chinese medicine preparation for treating children with autism spectrum disorders according to claim 1, characterized in that: The medicine is composed of or made from the following raw materials: calculated per 1000g, the contents of its components are 60g of Gastrodia elata, 60g of Alpinia oxyphylla, 60g of Platycladus orientalis, 45g of Angelica sinensis, 50g of Astragalus membranaceus, 18g of Salvia miltiorrhiza, 12g of Poria, 30g of Ligusticum chuanxiong, 18g of Paeonia suffruticosa, 30g of Dioscorea opposita, 18g of Atractylodes macrocephala, 12g of Bupleurum chinense, 9g of Radix Rehmanniae, 48g of Rhizoma Anemarrhenae, 30g of Costusroot, 60g of Polygala tenuifolia, 12g of Patchouli, 35g of Crataegus pinnatifida, 48g of Schisandra chinensis, 60g of Acorus calamus, 48g of Polygonatum sibiricum, 18g of Cimicifuga heracleifolia, 60g of Ganoderma lucidum, 18g of Peach Kernel, 30g of Carthamus tinctorius, 48g of Santalum album, 30g of Panax notoginseng, 30g of Radix Glycyrrhizae Preparata, and 3g of Stevia leaf.

4. A method for preparing a Chinese medicine preparation for treating children with autism spectrum disorders according to any one of claims 1 to 3, characterized in that: Its specific steps are as follows: S1. Wash the herbs according to the proportion, soak them in cold water for 2 hours, and boil them. Boil the herbs in a decoction bucket over high heat, turn to 70 degrees, keep warm for 12 hours, and then turn off the heat. S2, after cooling, filter out the liquid medicine, remove the remaining medicine residue with a dehydrator, mix the two liquid medicines and concentrate them to 20:1 to make a concentrated solution; S3, weigh the original medicinal materials according to the proportion, wash and dry them, crush them into 100-mesh raw medicinal powder, mix and stir the raw medicinal powder and concentrated solution in a ratio of 1:5, and then granulate or cut them into pieces and dry them; S4. After drying, crush to 120 mesh for later use. After sterilization, make into tablets, capsules or granules according to the situation.