A kind of Xiaoer Chaigui antipyretic granules and its automated production line and production method

Abstract

The present application discloses a kind of pediatric Chaigui antipyretic granules and its automated production line and production method, including an inner packaging device, the inner packaging device includes a frame, and a paper support component, a filling metering device, a bag forming mechanism, a middle sealing device, a horizontal sealing device, a cutting device, a bag turning mechanism and a feeding trough are respectively arranged on the frame, and the inner packaging device also includes a detection device, and the detection device is arranged on the feeding trough; the detection device includes a support movably arranged on the frame, a sampling inspection mechanism for sampling the medicinal composite film bag, an extrusion mechanism for extrusion detection of the medicinal composite film bag, and a recycling mechanism, the recycling mechanism is used to recycle the unpackaged particles in the package, the sampling inspection mechanism is used to collect the medicinal composite film bag dropped on the feeding trough, and the movement direction of the support moves in the horizontal direction. The present application has the characteristics of sweating and relieving the symptoms, clearing away heat and detoxifying, good taste, less loss of effective ingredients, stable quality, safe auxiliary materials, and convenient administration, and is mainly used to treat children's exogenous fever.

Description

Technical Field

[0001] The present application relates to the technical field of pediatric Chai Gui production, and in particular to a pediatric Chai Gui antipyretic granule and its automated production line and production method. Background Art

[0002] At present, Chinese medicine believes that children's fever is mainly caused by the feeling of exogenous pathogens, which enter the body and turn into heat, and the pathogenic heat is blazing. Children's skin is tender, the pores are not dense, and the function of defending the body is not solid. If there is a sudden change in climate and imbalance of cold and heat, pathogenic pathogens are easy to take advantage of the opportunity to enter. The wind-heat upper reception is that the wind-heat pathogen enters from the mouth and nose, invades the upper part of the body, and the aversion to cold is short-lived, and high fever, cough, thirst, sore throat, red tongue, and pulse rapidity appear immediately. This is the evil in the Wei Qi, and the treatment should be pungent and cool to penetrate the surface, clear and drain heat. That is, the evil is sweated and the fever is relieved. Follow the treatment principles of "opening the door to chase away thieves" and "eliminating evil and stabilizing the body", so that the evil has a way out and does not allow the pathogenic pathogen to penetrate deeply. The existing children's Chaigui antipyretic oral liquid has the following defects: because the prescription contains a large amount of volatile oil components, its clarity and stability have certain problems; and the oral liquid has a bad taste, although it has been corrected, children are still unwilling to take it; it is inconvenient to carry and transport, and it is easy to get infected with bacteria. After changing to granules, the stability of the drug is greatly increased, the taste is improved, and it is easy to carry and transport. It is also in line with the traditional Chinese medicine theory.

[0003] The production process of Chaigui Antipyretic Granules for Children is as follows: cinnamon twig and bupleurum are crushed, distilled, salted out, and refrigerated to extract volatile oil, beta-cyclodextrin is added to obtain a paste, the paste is dried and then crushed for later use; flavonoid components are extracted from Pueraria root by ethanol percolation; high-content baicalin is obtained from Scutellaria baicalensis by water extraction and acid precipitation; white peony root, duckweed, and cicada shell are decocted and concentrated to form a clear paste; the extracts are mixed and concentrated into a thick paste, and appropriate amounts of sucrose, beta-cyclodextrin inclusion compound and dextrin are added to make granules, and the dried whole granules are packaged in medicinal composite film bags and then packaged.

[0004] Regarding the above-mentioned related technologies, the inventors believe that there are the following defects: currently, the granules are packaged by a packaging machine, and there is no device to detect whether the packaging is intact after the packaging is completed. If the packaging is not well packaged, it will cause air leakage and even affect the quality of the Children's Chaigui Antipyretic Granules. Therefore, it is necessary to detect whether the packaging is good. Summary of the invention

[0005] In order to improve the problem of whether the quality and stability of the drug can be guaranteed after the granules are encapsulated internally, the present application provides a pediatric Chaigui antipyretic granules and an automated production line and production method thereof.

[0006] The automated production line of the Xiaoer Chaigui Antipyretic Granules provided in this application adopts the following technical solution:

[0007] An automated production line for Xiaoer Chaigui antipyretic granules comprises an inner packaging device, wherein the inner packaging device comprises a frame, and a paper supporting component, a filling and metering device, a bag forming mechanism, a middle sealing device, a horizontal sealing device, a cutting device, a bag turning mechanism and a feeding chute are respectively arranged on the frame.

[0008] The inner packaging device further comprises a detection device, and the detection device is arranged on the feeding chute;

[0009] The detection device includes a bracket movably arranged on the frame, a sampling mechanism for sampling the medicinal composite film bags, an extrusion mechanism for extrusion detection of the medicinal composite film bags, and a recovery mechanism, the recovery mechanism is used to recover the unpackaged particles in the package, the sampling mechanism is used to collect the medicinal composite film bags dropped from the feed chute, and the bracket moves in the horizontal direction.

[0010] Optionally, the sampling mechanism includes a sampling plate fixed on the bracket, a limiting plate for limiting the position of the medicinal composite film bag, and an adjusting component for adjusting the position of the medicinal composite film bag. The limiting plate slides above the sampling plate and is controlled by a power part. The adjusting component moves one end of the medicinal composite film bag along its length direction toward the limiting plate.

[0011] Optionally, the adjustment assembly includes two adjustment plates, a double-headed threaded rod, two sliders and an adjustment motor, the sampling plate is provided with an inner cavity, the double-headed threaded rod is rotatably provided in the inner cavity, the adjustment motor is fixed in the inner cavity and is used to control the rotation of the double-headed threaded rod, the two sliders are respectively screwed on the two ends of the double-headed threaded rod, the slider is fixedly connected to the adjustment plate, the slider slides in the slide groove and is fixedly connected to the bottom end of the adjustment plate, and the inner cavity is provided with a slide groove for sliding of the slider.

[0012] Optionally, the extrusion mechanism includes an extrusion frame lifted and lowered on the bracket, a fixing component for fixing the tail end of the medicinal composite film bag, an extrusion roller for extruding the medicinal composite film bag, and an identification component for identifying whether the medicinal composite film bag is damaged. The extrusion roller is movably arranged on the extrusion frame and its rotation axis is perpendicular to the length direction of the medicinal composite film bag. When the extrusion roller squeezes the medicinal composite film bag from the tail end to the front end, the tail end of the medicinal composite film bag will expand.

[0013] Optionally, the identification component is elastically arranged on the identification rod on the extrusion roller, the identification plate is fixed at the bottom end of the identification rod, and the trigger part is triggered by the identification rod, and the identification plate abuts against the tail end of the medicinal composite film bag.

[0014] Optionally, the trigger part includes a trigger plate, a trigger rod, a proximity switch and a buzzer, the trigger plate is hinged to the trigger rod, the position where the trigger plate and the trigger rod are hinged is not the midpoint, the trigger rod is raised and lowered on the extrusion frame, the position where the trigger rod and the trigger rod are hinged is close to the identification rod, one end of the identification rod abuts against one end of the trigger plate, the other end of the trigger plate abuts against the proximity switch, the proximity switch is located above the trigger plate, and the trigger plate abuts against the identification rod and the proximity switch and is in a horizontal state in the initial position.

[0015] Optionally, the collecting device includes a collecting rod hinged to the bracket, a torsion spring, a collecting plate fixed at the end of the collecting rod, a tearing assembly for tearing the medicinal composite film bag, a driving assembly for controlling the swing of the collecting rod, a recycling box, and a recycling assembly for recycling the medicinal composite film bags, the torsion spring ejects the collecting rod toward the sampling plate, the tearing assembly is arranged on the collecting plate, the driving assembly includes a gear, a rack, an electromagnet and a driving electric push rod, the gear is coaxially fixed to the collecting rod, the gear is meshingly connected to the rack, the rack slides on the bracket, the electromagnet is fixed at the output end of the driving electric push rod, the electromagnet is used to adsorb the end of the rack, and in the initial state, the electromagnet adsorbs the rack and the collecting rod is in a position away from the sampling plate, at which time the torsion spring is in a deformed state, and the recycling box is located at the position where the collecting rod is in the initial position, and after the medicinal composite film bag is torn, the particles fall into the recycling box.

[0016] Optionally, the tearing assembly includes two needles, two movable plates, two movable electric push rods respectively controlling the two movable plates to move outward, and two barbs. The two movable plates slide on the collecting plate, the tail ends of the needles are fixed on the movable plates, the barbs are fixed at positions close to the tips of the needles and the barbs are inclined toward the movable plates, and the sampling plate is provided with avoidance grooves for the entry of the needles and the barbs.

[0017] The present application provides a method for producing Chaigui Antipyretic Granules for Children, which adopts the following technical solution:

[0018] A method for producing Xiaoer Chaigui antipyretic granules comprises the following steps:

[0019] S1. Crush cinnamon twig and bupleurum root into coarse powder, add 12 times the amount of water, heat to 80°C, soak for 1 hour, distill for 4 hours, add 10% sodium chloride to the distillate, refrigerate for 12 hours, separate the upper oil, add 4 times the amount of beta-cyclodextrin and 8 times the amount of water, grind in a colloid mill for 20 to 30 minutes, and take out the paste;

[0020] S2, drying the paste in an oven at 50°C-60°C, and checking to ensure that the moisture is completely dried, crushing and sieving for later use; filtering the distilled water, adding 5-6 times the amount of water to the residue and boiling for 0.5-1 hour, filtering, combining the filtrate with the distilled water for later use;

[0021] S3. Take Pueraria root, crush it into the coarsest powder, and use the percolation method under the extract and fluid extract, using 50% ethanol as the solvent, soak for 24 hours and then percolate, collect 8 times the percolate, recover ethanol under reduced pressure, and continue to concentrate to a relative density of about 1.25;

[0022] S4, take Scutellaria baicalensis and crush it into the coarsest powder, bag and decoct it, add water and decoct it three times, add 8 times the amount of water for the first time, decoct it for 1 hour, add 8 times the amount of water for the second and third times, decoct it for 0.5 hours, combine the decoctions, filter, add 10% hydrochloric acid to the filtrate at 80-85°C to adjust the pH to 1.5-2.0, keep it warm for 1 hour, let it stand for 24 hours, filter it through 200 mesh, add 6 times the amount of water to the precipitate, stir and dissolve it, adjust the pH to 7.0-7.5 with 40% sodium hydroxide, add an equal amount of ethanol, filter it through 200 mesh, adjust the pH of the filtrate to 2.0 with 10% hydrochloric acid, keep it warm at 60°C for 30 minutes, let it stand for 24 hours, filter it through 200 mesh, wash the precipitate with water until it is neutral, and obtain a crude extract of Scutellaria baicalensis;

[0023] S5, take white peony root, duckweed, cicada shell and add water to decoct twice, add 10 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time to extract for 0.5 hours, combine the decoction, filter, combine the filtrate with the cinnamon twig and bupleurum water extract, concentrate to a relative density of about 1.07-1.10, add ethanol to make the alcohol content reach 60%, refrigerate for 24 hours, filter, recover ethanol under reduced pressure, and continue to concentrate to a relative density of about 1.25-1.28;

[0024] S6, combining the concentrated solution after recovering ethanol through water extraction and alcohol precipitation with the concentrated solution of Pueraria root extract, adding Scutellaria baicalensis extract; taking the obtained thick paste, adding appropriate amount of sucrose, dextrin, beta-cyclodextrin inclusion compound and sweet orange essence, making a soft material, making granules, drying, and granulating to obtain;

[0025] S7. Packaging: The particles are packaged in medicinal composite film bags, and during the inner packaging process, the medicinal composite film bags need to be sampled to determine whether there are air leaks in the medicinal composite film bags. If air leaks occur, all products in this batch need to be tested and the packaging machine needs to be debugged.

[0026] The Chaigui Antipyretic Granules for Children provided in this application adopt the following technical solution:

[0027] A kind of children's Chaigui antipyretic granules is prepared by utilizing the production method of the children's Chaigui antipyretic granules.

[0028] In summary, the present application includes at least one of the following beneficial technical effects:

[0029] 1. Xiaoer Chaigui Antipyretic Granules have the characteristics of sweating and relieving exterior symptoms, clearing away heat and detoxifying, good taste, less loss of effective ingredients, stable quality, safe auxiliary materials, and easy to take. It is mainly used to treat exogenous fever in children;

[0030] 2. If the medicinal composite film bag is tilted, the two adjustment plates will straighten the medicinal composite film bag, that is, the medicinal composite film bag is set along the length direction of the sampling plate without tilting, and is located in the middle of the sampling plate, which is convenient for subsequent squeezing operations. When the medicinal composite film bag is squeezed by the squeezing roller and the front end bulges, the identification sheet and the identification rod move upward. Through the lever principle, the distance that the other end of the trigger plate can be flipped becomes farther, thereby ensuring that the trigger plate can be away from the buzzer. As long as the trigger plate is away from the proximity switch, the buzzer can sound, proving that the medicinal composite film bag can push the identification rod, that is, the medicinal composite film bag is not damaged;

[0031] 3. When the medicinal composite film bag is determined to be damaged, the adsorption of the electromagnet and the rack is released at this time, and the electric push rod is driven to quickly move away from the rack. Under the elastic force of the torsion spring, the collecting rod is quickly ejected toward the direction of the sampling plate, and the pricking needle pierces the medicinal composite film bag. However, at this time, since the pricking needle still pierces the medicinal composite film bag, the particles in the medicinal composite film bag will not fall out. The driving electric push rod is then used to control the movement of the electromagnet. Under the mutual cooperation of the rack and the gear, the collecting rod swings toward the direction of the recycling box, and the mobile electric push rod is controlled to start moving. Under the action of the barbs, the two pricking needles move away from each other, which facilitates the tearing of the medicinal composite film bag. At this time, the particles fall from the medicinal composite film bag into the recycling box. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 It is a schematic diagram of the overall structure of the first embodiment of the present application;

[0033] Figure 2 is a schematic diagram of the detection device in Example 1 of the present application;

[0034] Figure 3 is a schematic diagram of the adjustment component in Example 1 of the present application;

[0035] Figure 4 is a schematic diagram of a recycling component in Example 1 of the present application;

[0036] Figure 5 It is a schematic diagram of the tearing assembly in Example 1 of the present application.

[0037] 1. Frame; 2. Feeding chute; 3. Bracket; 4. Inspection plate; 5. Limit plate; 6. Power part; 7. Adjustment plate; 8. Double-headed threaded rod; 9. Slider; 10. Adjustment motor; 11. Slide; 12. Extrusion rack; 13. Extrusion roller; 14. Identification rod; 15. Identification sheet; 16. Trigger plate; 17. Trigger rod; 18. Proximity switch; 19. Buzzer; 20. Collecting rod; 21. Torsion spring; 22. Collecting plate; 23. Recycling box; 24. Rack; 25. Gear; 26. Extrusion block; 27. Electromagnet; 28. Driving electric push rod; 29. ​​Needle; 30. Fixed rod; 31. Fixed plate; 32. Moving plate; 33. Moving electric push rod; 34. Barb; 35. Avoidance groove; 36. Recycling rack; 37. Manipulator; 38. Adhesive tape; 39. Winding roller; 40. Winding rope. DETAILED DESCRIPTION

[0038] The following is combined with Figure 1-5 This application is described in further detail. Embodiment 1

[0039] The present application embodiment discloses an automated production line for preparing Chaigui antipyretic granules for children. Figure 1-Figure 3 An automated production line for Chaigui antipyretic granules for children includes an internal packaging device, which includes a frame 1, and a paper supporting component, a filling and metering device, a bag forming device, a middle sealing device, a horizontal sealing device, a cutting device, a bag turning mechanism and a feeding chute 2 respectively arranged on the frame 1. Through the above modules, the Chaigui antipyretic granules for children can be packaged and bagged, and finally fall from the feeding chute 2 and are collected. Since the above-mentioned existing technology is adopted, it will not be repeated in this embodiment. It should be noted that the internal packaging equipment drops bags one by one from the feeding chute 2.

[0040] The inner packaging equipment also includes a detection device, which is arranged on the feed chute 2; the detection device includes a bracket 3 movably arranged on the frame 1, a sampling inspection mechanism for sampling the medicinal composite film bag, an extrusion mechanism for extrusion inspection of the medicinal composite film bag, and a recovery mechanism, the recovery mechanism is used to recover the unpackaged particles in the package, the sampling inspection mechanism is used to collect the medicinal composite film bag dropped from the feed chute 2, the bracket 3 moves in a horizontal direction, the movement direction of the bracket 3 can be along the falling direction of the medicinal composite film bag or perpendicular to the falling direction of the medicinal composite film bag, as long as it can be ensured that the sampling inspection mechanism can collect the medicinal composite film bag, after the sampling inspection mechanism completes the collection of the medicinal composite film bag, the extrusion mechanism squeezes the medicinal composite film bag, because there is some air in the medicinal composite film bag during the process of loading the particles, if the medicinal composite film bag is not damaged, the medicinal composite film bag will be squeezed and bulged, if it is damaged, the medicinal composite film bag will not bulge, and finally the broken medicinal composite film bag and the particles are encapsulated by the recovery mechanism.

[0041] Reference Figure 1-Figure 3 The sampling mechanism includes a sampling plate 4 fixed on the bracket 3, a limiting plate 5 for limiting the position of the medicinal composite film bag, and an adjusting component for adjusting the position of the medicinal composite film bag. The limiting plate 5 slides above the sampling plate 4 and is controlled by a power piece 6. The power piece 6 in this embodiment can be an electric push rod or a cylinder. When the sampling plate 4 follows the bracket 3 to move to the bottom of the feed chute 2, the medicinal composite film bag falls on the sampling plate 4, completing the sampling work of the medicinal composite film bag, and quickly pulling the bracket 3 to a position away from the feed chute 2 to ensure that the bracket 3 is not It will affect the normal unloading of the medicinal composite film bag. Due to the inertia of the medicinal composite film bag, the limiting plate 5 is required to limit the medicinal composite film bag. The limiting plate 5 moves in the vertical direction, and its initial position is located at one end of the sampling plate 4 and below the sampling plate 4. In this embodiment, the end of the medicinal composite film bag close to the sampling plate 4 is called the front end, and the other end of the medicinal composite film bag close to the sampling plate 4 is called the tail end, and the medicinal composite film bag originally falls along its length direction, so the front end abuts against the limiting plate 5, and the rear end is close to one end of the sampling plate 4.

[0042] The adjustment assembly includes two adjustment plates 7, a double-headed threaded rod 8, two sliders 9 and an adjustment motor 10. The sampling plate 4 is provided with an inner cavity. The double-headed threaded rod 8 is rotatably arranged in the inner cavity. The adjustment motor 10 is fixed in the inner cavity and is used to control the rotation of the double-headed threaded rod 8. The two sliders 9 are respectively screwed on the two ends of the double-headed threaded rod 8. The slider 9 is fixedly connected to the adjustment plate 7. The slider 9 slides in the slide groove 11 and is fixedly connected to the bottom end of the adjustment plate 7. The spiral directions of the two ends of the double-headed threaded rod 8 are opposite, that is, the two sliders 9 are respectively screwed with the two ends of the double-headed threaded rod 8. The inner cavity is provided with a slide groove 11 for the slider 9 to slide. The length direction of the slide groove 11 It is arranged along the width direction of the medicinal composite film bag; since the position of the medicinal composite film bag may be offset when it falls onto the sampling plate 4, that is, it is tilted, the adjusting motor 10 controls the double-headed threaded rod 8 to rotate, and the rotation of the slider 9 is restricted by the slide groove 11, so the slider 9 can only move along the length direction of the slide groove 11, and the two sliders 9 respectively drive the two adjustment plates 7 to move closer to each other. At this time, if the medicinal composite film bag is tilted, the two adjustment plates 7 will straighten the medicinal composite film bag, that is, the medicinal composite film bag is arranged along the length direction of the sampling plate 4 without tilting, and is located in the middle of the sampling plate 4, which is convenient for subsequent extrusion operations.

[0043] Reference Figure 1-Figure 3The extrusion mechanism includes an extrusion frame 12 which is lifted and arranged on the bracket 3, a fixing component for fixing the tail end of the medicinal composite film bag, an extrusion roller 13 for extruding the medicinal composite film bag, and an identification component for marking whether the medicinal composite film bag is damaged. The extrusion roller 13 is movably arranged on the extrusion frame 12 and its rotation axis is perpendicular to the length direction of the medicinal composite film bag. When the extrusion roller 13 squeezes the medicinal composite film bag from the tail end to the front end, the tail end of the medicinal composite film bag will expand. The lifting and lowering of the extrusion frame 12 can be achieved by an electric push rod or a cylinder. The extrusion frame 12 is slidably connected to an extrusion block 26 along the length direction of the medicinal composite film bag, and an extrusion electric push rod for controlling the movement of the extrusion block 26 is installed on the extrusion frame 12. The extrusion roller 13 is rotatably arranged on the extrusion block 26, the length direction of the extrusion roller 13 is perpendicular to the length direction of the medicinal composite film bag, and the fixing component includes a fixing rod 30 and a fixing plate 31. The fixing rod 30 is fixedly connected to the extrusion frame 12, and the fixing plate 31 is fixedly connected to the bottom end of the fixing rod 30. The fixing plate 31 squeezes the medicinal composite film bag on the sampling plate 4 and fixes it. When the fixing plate 31 squeezes and positions the tail end of the medicinal composite film bag, the extrusion electric push rod controls the movement of the extrusion block 26, and the extrusion roller 13 starts to move along the tail end of the medicinal composite film bag toward the front end. If the medicinal composite film bag is intact, the front end of the medicinal composite film bag bulges, and in this embodiment, the movement distance of the extrusion roller 13 is set to be less than the length of the medicinal composite film bag, and the medicinal composite film bag cannot be squeezed and damaged.

[0044] The identification component is elastically arranged on the identification rod 14 on the extrusion roller 13, the identification piece 15 fixed at the bottom end of the identification rod 14 and the trigger part. The trigger part is triggered by the identification rod 14, and the identification plate abuts against the tail end of the medicinal composite film bag. The extrusion frame 12 is provided with an identification hole, and the identification rod 14 passes through the identification hole. The outer sleeve of the identification rod 14 is provided with a spring, one end of the spring is fixedly connected to the extrusion frame 12, and the other end is fixedly connected to the identification piece 15. Of course, in this embodiment, the identification piece 15 can also be inserted into the identification hole, and the identification rod 14 and the identification piece 15 naturally droop on the medicinal composite film bag by their own weight. When the fixing plate 31 squeezes the bottom end of the medicinal composite film bag into position, the identification piece 15 just abuts against the front end of the medicinal composite film bag, and the spring is in a naturally drooping state. The identification rod 14 and the identification piece 15 are made of light material, and the elastic force of the spring is much smaller than the thrust applied to the identification piece 15 when the medicinal composite film bag is bulging.

[0045] The triggering part includes a triggering plate 16, a triggering rod 17, a proximity switch 18 and a buzzer 19. The triggering plate 16 is hinged to the triggering rod 17. The hinged position of the triggering plate 16 and the triggering rod 17 is not the midpoint position. The triggering rod 17 is raised and lowered on the extrusion frame 12. The hinged position of the triggering rod 17 and the triggering rod 17 is close to the identification rod 14. One end of the identification rod 14 abuts against one end of the triggering plate 16, and the other end of the triggering plate 16 abuts against the proximity switch 18. The proximity switch 18 is located above the triggering plate 16. In the initial position, the triggering plate 16 abuts against the identification rod 14 and the proximity switch 18 and is in a horizontal state. Since the bulging state of each medicinal composite film bag is inconsistent in the initial state, the identification sheet 15 The position is also different, so the trigger rod 17 needs to be raised and lowered to make the trigger plate 16 abut against the top of the identification rod 14, and the position where the trigger rod 17 and the trigger plate 16 are hinged is close to the identification rod 14. The main function is to reduce the distance that the trigger plate 16 is pushed during the bulging of the medicinal composite film bag. Through the lever principle, the flipping distance of the other end of the trigger plate 16 can be made farther, thereby ensuring that the trigger plate 16 can be away from the buzzer 19, and the proximity switch 18 and the buzzer 19 are controlled and connected by a PLC controller. As long as the trigger plate 16 is away from the proximity switch 18, the buzzer 19 can make a sound, proving that the medicinal composite film bag can push the identification rod 14, that is, the medicinal composite film bag is not damaged.

[0046] Reference Figure 1-Figure 3 The collecting device includes a collecting rod 20 hinged to the bracket 3, a torsion spring 21, a collecting plate 22 fixed to the end of the collecting rod 20, a tearing assembly for tearing the medicinal composite film bag, a driving assembly for controlling the swing of the collecting rod 20, a recycling box 23, and a recycling assembly for recycling the medicinal composite film bag. The torsion spring 21 ejects the collecting rod 20 toward the sampling plate 4, and the tearing assembly is arranged on the collecting plate 22. The two ends of the torsion spring 21 are fixedly connected to the collecting rod 20 and the bracket 3 respectively. The collecting rod 20 and the bracket 3 The hinged position is located at one end of the collecting rod 20, and the collecting plate 22 is located at the movable end of the collecting rod 20. When it is proved that the medicinal composite film bag is damaged, it is necessary to collect the medicinal composite film bag. When there is no problem with the medicinal composite film bag, the staff can take it away. Because when the plastic is damaged, if the operator at the inner sealing position takes it, it will cause the particles to scatter. Of course, a robot arm can also be set on the sampling plate 4 to clamp the complete medicinal composite film bag on the sampling plate 4 to the position of the discharge trough 2 so that it can fall normally.

[0047] Reference Figure 2-Figure 5The driving assembly includes a gear 25, a rack 24, an electromagnet 27 and a driving electric push rod 28. The gear 25 is coaxially fixed with the collecting rod 20. The gear 25 is meshed with the rack 24. The rack 24 slides on the bracket 3. The electromagnet 27 is fixed at the output end of the driving electric push rod 28. The electromagnet 27 is used to adsorb the end of the rack 24. In the initial state, the electromagnet 27 adsorbs the rack 24 and the collecting rod 20 is in a position away from the sampling plate 4. At this time, the torsion spring 21 is in a deformed state, and the recycling box 23 is located at the position where the collecting rod 20 is in the initial position. After the medicinal composite film bag is torn, the particles fall into the recycling box 23. In the initial state, the collecting rod 20 is located away from the sampling inspection plate 4. When the medicinal composite film bag is determined to be damaged, the adsorption effect on the electromagnet 27 and the rack 24 is released at this time, and the electric push rod 28 is driven to quickly move away from the rack 24. Under the elastic force of the torsion spring 21, the collecting rod 20 is quickly ejected toward the sampling inspection plate 4, and the tearing assembly recovers the medicinal composite film bag. When the collecting rod 20 needs to be recovered, the rack 24 is adsorbed by the electromagnet 27. Through the mutual cooperation of the rack 24 and the gear 25, the collecting rod 20 is pulled toward the direction away from the sampling inspection plate 4, and the torsion spring 21 is deformed.

[0048] The tearing assembly includes two needles 29, two movable plates 32, two movable electric push rods 33 for respectively controlling the two movable plates 32 to move outward, and two barbs 34. The two movable plates 32 slide on the collecting plate 22, and the tail ends of the needles 29 are fixed on the movable plates 32. The barbs 34 are fixed at positions close to the tips of the needles 29 and the barbs 34 are inclined toward the movable plates 32. An avoidance groove 35 for the needles 29 and the barbs 34 to enter is provided on the sampling plate; the two needles 29 are located close to each other, and when the collecting rod 20 swings toward the sampling plate 4, the opening size of the avoidance groove 35 is sufficient for the two needles 29 to penetrate, so the needles 29 puncture the medicinal composite film bag, but at this time, since the needles 29 still penetrate the medicinal composite film bag, The particles in this medicinal composite film bag will not fall out, and the driving electric push rod 28 is used to control the movement of the electromagnet 27. Under the mutual cooperation of the rack 24 and the gear 25, the collecting rod 20 swings toward the direction of the recycling box 23. Since the collecting plate 22 is set in a frame shape in this embodiment, when the medicinal composite film bag follows the needle 29 to move to the top of the recycling box 23, and then the moving electric push rod 33 is controlled to start moving, under the action of the barb 34, the two needles 29 move away from each other, which facilitates the tearing of the medicinal composite film bag. At this time, the particles fall from the medicinal composite film bag into the recycling box 23, and only a small part of the particles may remain on the collecting plate 22, which can be ignored in this embodiment, thereby completing the recovery effect of the particles in the medicinal composite film bag.

[0049] Reference Figure 2-Figure 5The recycling component includes a recycling rack 36 that is lifted and arranged on the bracket 3, a manipulator 37 that is lifted and arranged on the recycling rack 36, an adhesive tape 38 that is movably arranged under the manipulator 37, and a winding part for winding the adhesive tape 38. The manipulator 37 is used to clamp the medicinal composite film bag. The manipulator 37 tears the medicinal composite film bag from the puncture needle 29 and drops it onto the adhesive tape 38. The lifting and lowering of the recycling rack 36 and the manipulator 37 are also achieved by an electric push rod. The manipulator 37 can use the existing technology to clamp the medicinal composite film bag. The adhesive tape 38 can use transparent tape, and the adhesive side of the adhesive tape 38 faces the manipulator 37. The winding part has multiple winding ropes 40, two winding rollers 39 and two winding motors. The two winding rollers 39 are respectively located on both sides of the machine. The multiple winding ropes 40 are divided into two groups. The two winding ropes 40 connect the adjacent adhesive tapes 38 to ensure that the machine The manipulator 37 can pass between the two winding ropes 40, and the winding motor is used to control the rotation of the winding roller 39. The winding ropes 40 at both ends are fixedly connected to the outer peripheral walls of the two winding rollers 39 respectively; when the particles in the medicinal composite film bag have fallen out, the rack 24 is gradually moved until the collecting rod 20 and the collecting plate 22 are moved to a vertical position. At this time, the recovery frame 36 is lowered, and the manipulator 37 is controlled to descend. The manipulator 37 pulls the adhesive tape 38, and under the action of the barbs 34, the medicinal composite film bag can be smoothly torn and separated from the puncture needle 29, and then the machine is moved above the winding rope 40, and the two winding motors are controlled to work, and the adhesive tape 38 moves to the bottom of the manipulator 37, and the manipulator 37 releases the medicinal composite film bag, and the medicinal composite film bag falls onto the adhesive tape 38, and the adhesive tape 38 collects the medicinal composite film bag, thereby achieving the collection effect of the broken medicinal composite film bag.

[0050] The implementation principle of an automated production line for Chaigui antipyretic granules for children in an embodiment of the present application is as follows: when the sampling plate 4 follows the bracket 3 to move to the bottom of the feed chute 2, the medicinal composite film bag falls on the sampling plate 4, and the sampling work of the medicinal composite film bag is completed, and the bracket 3 is quickly pulled to a position away from the feed chute 2 to ensure that the bracket 3 does not affect the normal feeding work of the medicinal composite film bag. Due to the inertia of the medicinal composite film bag, the limiting plate 5 is required to limit the medicinal composite film bag. The limiting plate 5 moves in the vertical direction. If the medicinal composite film bag is tilted, the two adjustment plates 7 will straighten the medicinal composite film bag, that is, the medicinal composite film bag is arranged along the length direction of the sampling plate 4 without tilting, and is located in the middle of the sampling plate 4 to facilitate subsequent extrusion operations.

[0051] If the medicinal composite film bag is tilted, the two adjustment plates 7 will straighten the medicinal composite film bag, that is, the medicinal composite film bag is arranged along the length direction of the sampling plate 4 without being tilted, and is located in the middle of the sampling plate 4 to facilitate subsequent extrusion operations. When the medicinal composite film bag is squeezed by the extrusion roller 13 and the front end bulges, the identification sheet 15 and the identification rod 14 move upward. Through the lever principle, the flipping distance of the other end of the trigger plate 16 can be increased, thereby ensuring that the trigger plate 16 can be away from the buzzer 19. As long as the trigger plate 16 is away from the proximity switch 18, the buzzer 19 can make a sound, proving that the medicinal composite film bag can push the identification rod 14, that is, the medicinal composite film bag is not damaged.

[0052] When the medicinal composite film bag is determined to be damaged, the adsorption effect on the electromagnet 27 and the rack 24 is released, and the electric push rod 28 is driven to quickly move away from the rack 24. Under the elastic force of the torsion spring 21, the collecting rod 20 is quickly ejected toward the direction of the sampling inspection plate 4, and the puncture needle 29 punctures the medicinal composite film bag. However, at this time, since the puncture needle 29 still pierces the medicinal composite film bag, the particles in the medicinal composite film bag will not fall out. The driving electric push rod 28 is then used to control the movement of the electromagnet 27. Under the mutual cooperation of the rack 24 and the gear 25, the collecting rod 20 swings toward the direction of the recycling box 23, and the moving electric push rod 33 is controlled to start moving. Under the action of the barbs 34, the two puncture needles 29 move away from each other, which facilitates the tearing of the medicinal composite film bag. At this time, the particles fall from the medicinal composite film bag into the recycling box 23;

[0053] When all the particles in the medicinal composite film bag have fallen out, the rack 24 is gradually moved until the collecting rod 20 and the collecting plate 22 are moved to a vertical position. At this time, the recovery frame 36 is lowered, and the manipulator 37 is controlled to descend. The manipulator 37 pulls the adhesive tape 38, and under the action of the barbs 34, the medicinal composite film bag can be smoothly torn and separated from the puncture needle 29. Then the machine is moved above the winding rope 40, and the two winding motors are controlled to work. The adhesive tape 38 moves to the bottom of the manipulator 37, and the manipulator 37 releases the medicinal composite film bag, and the medicinal composite film bag falls onto the adhesive tape 38. The adhesive tape 38 collects the medicinal composite film bag, thereby achieving the collection effect of the broken medicinal composite film bag. Embodiment 2

[0054] The present application example discloses a method for producing a pediatric Chaigui antipyretic granule. Figure 1 A method for producing Xiaoer Chaigui Antipyretic Granules comprises the following steps:

[0055] S1. Crush cinnamon twig and bupleurum root into coarse powder, add 12 times the amount of water, heat to 80°C, soak for 1 hour, distill for 4 hours, add 10% sodium chloride to the distillate, refrigerate for 12 hours, separate the upper oil, add 4 times the amount of beta-cyclodextrin and 8 times the amount of water, grind in a colloid mill for 20 to 30 minutes, and take out the paste;

[0056] S2, drying the paste in an oven at 50°C-60°C, and checking to ensure that the moisture is completely dried, crushing and sieving for later use; filtering the distilled water, adding 5-6 times the amount of water to the residue and boiling for 0.5-1 hour, filtering, combining the filtrate with the distilled water for later use;

[0057] S3. Take Pueraria root, crush it into the coarsest powder, and use the percolation method under the extract and fluid extract, using 50% ethanol as the solvent, soak for 24 hours and then percolate, collect 8 times the percolate, recover ethanol under reduced pressure, and continue to concentrate to a relative density of about 1.25;

[0058] S4, take Scutellaria baicalensis and crush it into the coarsest powder, bag and decoct it, add water and decoct it three times, add 8 times the amount of water for the first time, decoct it for 1 hour, add 8 times the amount of water for the second and third times, decoct it for 0.5 hours, combine the decoctions, filter, add 10% hydrochloric acid to the filtrate at 80-85°C to adjust the pH to 1.5-2.0, keep it warm for 1 hour, let it stand for 24 hours, filter it through 200 mesh, add 6 times the amount of water to the precipitate, stir and dissolve it, adjust the pH to 7.0-7.5 with 40% sodium hydroxide, add an equal amount of ethanol, filter it through 200 mesh, adjust the pH of the filtrate to 2.0 with 10% hydrochloric acid, keep it warm at 60°C for 30 minutes, let it stand for 24 hours, filter it through 200 mesh, wash the precipitate with water until it is neutral, and obtain a crude extract of Scutellaria baicalensis;

[0059] S5, take white peony root, duckweed, cicada shell and add water to decoct twice, add 10 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time to extract for 0.5 hours, combine the decoction, filter, combine the filtrate with the cinnamon twig and bupleurum water extract, concentrate to a relative density of about 1.07-1.10, add ethanol to make the alcohol content reach 60%, refrigerate for 24 hours, filter, recover ethanol under reduced pressure, and continue to concentrate to a relative density of about 1.25-1.28;

[0060] S6, combining the concentrated solution after recovering ethanol through water extraction and alcohol precipitation with the concentrated solution of Pueraria root extract, adding Scutellaria baicalensis extract; taking the obtained thick paste, adding appropriate amount of sucrose, dextrin, beta-cyclodextrin inclusion compound and sweet orange essence, making a soft material, making granules, drying, and granulating to obtain;

[0061] S7. Packaging: The particles are packaged in a medicinal composite film bag, and during the inner packaging process, the medicinal composite film bag needs to be sampled to determine whether the medicinal composite film bag has leakage or the like. If leakage occurs, all products in the batch need to be tested and the packaging machine needs to be debugged. That is, when the medicinal composite film bag is squeezed by the squeezing roller 13 and the front end bulges, the identification sheet 15 and the identification rod 14 move upward, and through the lever principle, the distance that the other end of the trigger plate 16 flips can be increased, thereby ensuring that the trigger plate 16 can be away from the buzzer 19. As long as the trigger plate 16 is away from the proximity switch 18, the buzzer 19 can make a sound, proving that the medicinal composite film bag can push the identification rod 14, that is, the medicinal composite film bag is not damaged, and the particles in the damaged medicinal composite film bag are recovered into the recovery box 23 and the medicinal composite film bag is collected by the adhesive tape 38. Embodiment 3

[0062] The present application example discloses a kind of Xiaoer Chaigui antipyretic granules. Figure 1 A kind of pediatric Chaigui antipyretic granules is prepared by the production method of the pediatric Chaigui antipyretic granules in Example 2, comprising the following raw medicinal materials in parts by weight: 702 parts of bupleurum; 243 parts of cinnamon twig; 702 parts of kudzu root; 324 parts of scutellaria baicalensis; 243 parts of duckweed; 243 parts of white peony root; 243 parts of cicada shell; the weight ratio of the mixture of the above drugs and the auxiliary materials is: mixture of drugs: 447-608 parts of thick paste, 5-7 parts of betadextrin inclusion compound; auxiliary materials: 1755 parts of sucrose, 750 parts of dextrin, 4.05 parts of sweet orange essence. The pediatric Chaigui antipyretic granules prepared by the above ingredients have the characteristics of sweating and relieving exterior symptoms, clearing away heat and detoxifying, good taste, less loss of effective ingredients, stable quality, safe auxiliary materials, and easy to take, and are mainly used to treat exogenous fever in children.

[0063] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. An automated production line for Xiaoer Chaigui antipyretic granules, comprising an inner packaging device, the inner packaging device comprising a frame (1), and a paper support component, a filling and metering device, a bag forming mechanism, a middle sealing device, a horizontal sealing device, a cutting device, a bag turning mechanism and a feeding chute (2) respectively arranged on the frame (1), characterized in that: The inner packaging device further comprises a detection device, wherein the detection device is arranged on the feed chute (2); The detection device comprises a support (3) movably arranged on the frame (1), a sampling mechanism for sampling the medicinal composite film bags, an extrusion mechanism for extrusion detection of the medicinal composite film bags, and a recovery mechanism, wherein the recovery mechanism is used to recover the unpackaged particles in the package, the sampling mechanism is used to collect the medicinal composite film bags dropped from the feed chute (2), and the support (3) moves in a horizontal direction; The sampling inspection mechanism comprises a sampling inspection plate (4) fixed on the bracket (3), a limiting plate (5) for limiting the position of the medicinal composite film bag, and an adjusting component for adjusting the position of the medicinal composite film bag, wherein the limiting plate (5) slides above the sampling inspection plate (4) and is controlled by a power member (6), and the adjusting component moves one end of the medicinal composite film bag along its length direction toward the limiting plate (5); The squeezing mechanism comprises an squeezing frame (12) which is lifted and arranged on the support (3), a fixing component for fixing the rear end of the medicinal composite film bag, an squeezing roller (13) for squeezing the medicinal composite film bag, and an identification component for identifying whether the medicinal composite film bag is damaged, wherein the squeezing roller (13) is movably arranged on the squeezing frame (12) and its rotation axis is perpendicular to the length direction of the medicinal composite film bag, and when the squeezing roller (13) squeezes the medicinal composite film bag from the rear end to the front end, the rear end of the medicinal composite film bag will expand; the identification component is elastically arranged on the squeezing roller (13) The identification rod (14), the identification sheet (15) fixed at the bottom end of the identification rod (14) and a trigger part, the trigger part is triggered by the identification rod (14), and the identification sheet (15) abuts against the rear end of the medicinal composite film bag; the trigger The triggering part comprises a trigger plate (16), a trigger rod (17), a proximity switch (18) and a buzzer (19); the trigger plate (16) is hinged to the trigger rod (17); the position where the trigger plate (16) and the trigger rod (17) are hinged is not the midpoint position; the trigger rod (17) is lifted and lowered on the extrusion frame (12); the position where the trigger plate (16) and the trigger rod (17) are hinged is close to the identification rod (14); one end of the identification rod (14) abuts against one end of the trigger plate (16); the other end of the trigger plate (16) abuts against the proximity switch (18); the proximity switch (18) is located above the trigger plate (16); and the trigger plate (16) abuts against the identification rod (14) and the proximity switch (18) in the initial position and is in a horizontal state; The recycling mechanism comprises a collecting rod (20) hinged to the bracket (3), a torsion spring (21), a collecting plate (22) fixed to the end of the collecting rod (20), a tearing assembly for tearing the medicinal composite film bag, a driving assembly for controlling the swing of the collecting rod (20), a recycling box (23), and a recycling assembly for recycling the medicinal composite film bag. The torsion spring (21) ejects the collecting rod (20) toward the sampling plate (4). The tearing assembly is arranged on the collecting plate (22). The driving assembly comprises a gear (25), a rack (24), an electromagnet (27) and a driving electric push rod (28). The gear (25) is coaxially fixed with the collecting rod (20). The gear (25) is meshingly connected with the rack (24). The rack (24) slides on the bracket (3). The electromagnet (27) is fixed to the output end of the driving electric push rod (28). The electromagnet (27) is used to adsorb the rack (2 4), the electromagnet (27) absorbs the rack (24) in the initial state and the collecting rod (20) is in a position away from the sampling plate (4), at this time the torsion spring (21) is in a deformed state, the recovery box (23) is located at the position where the collecting rod (20) is in the initial position, and the particles of the medicinal composite film bag fall into the recovery box (23) after being torn; the tearing assembly includes two needles (29), two movable plates (32), two A movable electric push rod (33) and two barbs (34) are provided for respectively controlling the two movable plates (32) to move outwards. The two movable plates (32) slide on the collecting plate (22). The tail end of the needle (29) is fixed on the movable plate (32). The barb (34) is fixed at a position close to the tip of the needle (29) and the barb (34) is inclined toward the movable plate (32). The sampling plate (4) is provided with an avoidance groove (35) for the needle (29) and the barb (34) to enter.

2. The automated production line of Xiaoer Chaigui Antipyretic Granules according to claim 1 is characterized in that: The adjustment component comprises two adjustment plates (7), a double-headed threaded rod (8), two sliders (9) and an adjustment motor (10); the sampling plate (4) is provided with an inner cavity, the double-headed threaded rod (8) is rotatably arranged in the inner cavity, the adjustment motor (10) is fixed in the inner cavity and is used to control the rotation of the double-headed threaded rod (8); the two sliders (9) are respectively screwed on the two ends of the double-headed threaded rod (8); the slider (9) is fixedly connected to the adjustment plate (7); the inner cavity is provided with a slide groove (11) for the slider (9) to slide; the slider (9) slides in the slide groove (11) and is fixedly connected to the bottom end of the adjustment plate (7).

3. A method for producing Chaigui Antipyretic Granules for Children, based on the automated production line of Chaigui Antipyretic Granules for Children according to any one of claims 1-2, characterized in that: The steps include: S1. Crush cinnamon twig and bupleurum root into coarse powder, add 12 times the amount of water, heat to 80°C, soak for 1 hour, distill for 4 hours, add 10% sodium chloride to the distillate, refrigerate for 12 hours, separate the upper oil, add 4 times the amount of beta-cyclodextrin and 8 times the amount of water, grind in a colloid mill for 20 to 30 minutes, and take out the paste; S2, drying the paste in an oven at 50°C-60°C, and checking to ensure that the moisture is completely dried, crushing and sieving for later use; filtering the distilled water, adding 5-6 times the amount of water to the residue and boiling for 0.5-1 hour, filtering, combining the filtrate with the distilled water for later use; S3. Take Pueraria root, crush it into the coarsest powder, and use the percolation method under the extract and fluid extract, using 50% ethanol as the solvent, soak for 24 hours and then percolate, collect 8 times the percolate, recover ethanol under reduced pressure, and continue to concentrate to a relative density of about 1.25; S4, take Scutellaria baicalensis and crush it into the coarsest powder, bag and decoct it, add water and decoct it three times, add 8 times the amount of water for the first time, decoct it for 1 hour, add 8 times the amount of water for the second and third times, decoct it for 0.5 hours, combine the decoctions, filter, add 10% hydrochloric acid to the filtrate at 80-85°C to adjust the pH to 1.5-2.0, keep it warm for 1 hour, let it stand for 24 hours, filter it through 200 mesh, add 6 times the amount of water to the precipitate, stir and dissolve it, adjust the pH to 7.0-7.5 with 40% sodium hydroxide, add an equal amount of ethanol, filter it through 200 mesh, adjust the pH of the filtrate to 2.0 with 10% hydrochloric acid, keep it warm at 60°C for 30 minutes, let it stand for 24 hours, filter it through 200 mesh, wash the precipitate with water until it is neutral, and obtain a crude extract of Scutellaria baicalensis; S5, take white peony root, duckweed, cicada shell and add water to decoct twice, add 10 times the amount of water for the first time, extract for 1 hour, add 10 times the amount of water for the second time to extract for 0.5 hour, combine the decoction, filter, combine the filtrate with the cinnamon twig and bupleurum water extract, concentrate to a relative density of 1.07-1.10, add ethanol to make the alcohol content reach 60%, refrigerate for 24 hours, filter, recover ethanol under reduced pressure, and continue to concentrate to a relative density of 1.25-1.28; S6, combining the concentrated solution after recovering ethanol through water extraction and alcohol precipitation with the concentrated solution of Pueraria root extract, adding Scutellaria baicalensis extract; taking the obtained thick paste, adding appropriate amount of sucrose, dextrin, beta-cyclodextrin inclusion compound and sweet orange essence, making a soft material, making granules, drying, and granulating to obtain; S7. Packaging: The particles are packaged in medicinal composite film bags, and during the inner packaging process, the medicinal composite film bags need to be sampled to determine whether there is any leakage in the medicinal composite film bags. If leakage occurs, all products in this batch need to be tested and the packaging machine needs to be debugged.

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