Traditional Chinese medicine composition for treating skin inflammation caused by damp-heat and preparation method thereof

Abstract

The embodiment of the invention discloses a traditional Chinese medicine composition for treating skin inflammation caused by damp-heat and a preparation method thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: 8-12 parts of rheum officinale, 15-25 parts of radix sophorae flavescentis, 8-12 parts of radix paeoniae rubra, 12-18 parts of cortex phellodendri, 12-18 parts of flos chrysanthemi indici, 8-12 parts of rhizoma atractylodis, 12-18 parts of rhizoma coptidis tablets and 5-8 parts of liquorice. The traditional Chinese medicine composition provided by the invention has the effects of clearing heat, promoting diuresis, purging fire and detoxifying, is used for treating skin inflammation caused by damp-heat, particularly has a remarkable curative effect on perianal eczema, can obviously improve symptoms such as perianal itching, swelling and pain and the like, is high in safety and has a relatively good clinical popularization value.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and specifically to a traditional Chinese medicine composition for treating skin inflammation caused by damp heat and a preparation method thereof. Background Art

[0002] Skin diseases caused by damp heat include eczema, pemphigus, pemphigoid, herpes zoster, lupus erythematosus, erythema multiforme, dermatomyositis, scleroderma, etc., which are manifested by skin erythema, papules, and itching. In severe cases, dry skin, cracks, and exudation may occur.

[0003] Perianal eczema is a common perianal inflammatory skin disease that can occur in any age group. It can cause flaky erythema, papules, blisters or lichenoid lesions on the perianal skin, accompanied by local itching symptoms, and often recurrent attacks. Due to the particularity of the site of onset of perianal eczema, it causes great physical and mental pain to patients. At present, Western medicine clinical practice has no ideal treatment method for this, and generally adopts anti-allergic and anti-inflammatory treatment for symptomatic treatment. Levocetirizine tablets and hydrocortisone butyrate ointment are both commonly used Western medicines for the treatment of perianal eczema, but they are prone to relapse after discontinuation of the drug, and adverse reactions are obvious during long-term use. Summary of the invention

[0004] To this end, the embodiments of the present invention provide a Chinese medicine composition and a preparation method for treating skin inflammation caused by damp heat. The Chinese medicine composition is an ancestral prescription, which has been proven to be effective in treating skin inflammation caused by damp heat, especially perianal eczema, and has passed the approval and appraisal of the "Intangible Cultural Heritage Project".

[0005] In order to achieve the above purpose, the embodiment of the present invention provides the following technical solutions:

[0006] According to a first aspect of an embodiment of the present invention, the present invention provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, wherein the traditional Chinese medicine composition comprises, by weight: 8-12 parts of rhubarb, 15-25 parts of sophora flavescens, 8-12 parts of red peony root, 12-18 parts of phellodendron chinense, 12-18 parts of wild chrysanthemum, 8-12 parts of atractylodes, 12-18 parts of coptis slices, and 5-8 parts of licorice.

[0007] Furthermore, the Chinese medicine composition comprises, by weight: 10 parts of rhubarb, 20 parts of sophora flavescens, 10 parts of red peony root, 15 parts of phellodendron, 15 parts of wild chrysanthemum, 10 parts of atractylodes, 15 parts of coptis slices, and 6 parts of liquorice.

[0008] Furthermore, the dosage form of the Chinese medicine composition is an external preparation.

[0009] Furthermore, the external preparation is a powder.

[0010] Furthermore, the skin inflammation includes perianal eczema.

[0011] According to a second aspect of an embodiment of the present invention, the present invention provides a method for preparing the above-mentioned Chinese medicine composition for treating skin inflammation caused by damp heat, wherein each medicinal material is weighed according to a weight ratio, mixed, and then crushed and sieved.

[0012] Furthermore, the sieved particle size is 200-300 mesh.

[0013] The effects of each raw material used in the present invention are as follows:

[0014] Rhubarb: bitter, cold. Enters the stomach meridian, large intestine meridian, and liver meridian. It can purge heat and toxins, break up stagnation, and promote blood circulation.

[0015] Sophora flavescens: bitter in taste, cold in nature. Enters the heart, liver, stomach, large intestine, and bladder meridians. Clears away heat and dampness, kills insects, and is a diuretic.

[0016] Red Peony Root: bitter, slightly cold. Enters the Liver Channel. Clears away heat, cools blood, dissipates blood stasis and relieves pain.

[0017] Phellodendron chinense: bitter, cold in nature. Kidney and bladder meridians. Has the effects of clearing away heat and dampness, purging fire and removing steam, detoxifying and curing sores.

[0018] Wild chrysanthemum: bitter, pungent, slightly cold. Enters the liver meridian and heart meridian. Dispels wind and heat, reduces swelling and detoxifies.

[0019] Atractylodes: pungent, bitter, warm in nature. Enters the spleen, stomach, and liver meridians. Drys dampness and strengthens the spleen, dispels wind and cold, and improves eyesight.

[0020] Huanglian Tablets: bitter; cold. Heart meridian; liver meridian; stomach meridian; large intestine meridian. Purging fire, drying dampness, detoxifying, killing insects.

[0021] Licorice: sweet, neutral. Enters the spleen, stomach and lung meridians. Harmonizes the middle and relieves urgency, moistens the lungs, detoxifies, and harmonizes various medicines.

[0022] The compatibility relationship of the Chinese medicine composition for treating skin inflammation caused by damp heat provided by the present invention is as follows:

[0023] Junyao

[0024] The main drug is the drug in the prescription that plays the main role in treating the main disease. Rhubarb and Sophora flavescens can be the main drugs. Rhubarb can clear away heat and purge fire, detoxify and relieve constipation, while Sophora flavescens can kill insects, dry dampness and clear heat.

[0025] Minister medicine

[0026] Minister drugs assist monarch drugs and enhance or expand the effects of monarch drugs. Red peony root is a minister drug, which can cool blood, activate blood circulation, and help rhubarb and sophora flavescens to remove heat and toxins from the body.

[0027] Adjuvant

[0028] Adjuvant drugs are used to help the main and auxiliary drugs to work better, or to treat concurrent symptoms. Phellodendron chinense and wild chrysanthemum can help the main drug to clear away heat and detoxify. Phellodendron chinense can also dry dampness and cool blood, while wild chrysanthemum is good at clearing heat and detoxifying.

[0029] Drug

[0030] The guiding drugs are mainly used to guide other drugs to the lesion site, or to coordinate the effects of the entire prescription. Atractylodes, Coptis chinensis and Licorice are guiding drugs. Atractylodes can dry out dampness and strengthen the spleen, Coptis chinensis can clear away heat and dampness, purge fire and detoxify, and Licorice coordinates the drugs.

[0031] Used to treat symptoms such as skin inflammation, perianal swelling and pain caused by damp heat.

[0032] The embodiments of the present invention have the following advantages:

[0033] 1. The Chinese medicine composition provided by the present invention uses specific amounts of rhubarb, sophora flavescens, red peony root, phellodendron, wild chrysanthemum, atractylodes, coptis slices, and liquorice as raw materials. The components exert the greatest synergistic effect, have the effects of clearing away heat and dampness, purging fire and detoxifying, and are used to treat skin inflammation caused by damp heat, especially for perianal eczema, and can significantly improve symptoms such as perianal itching, swelling and pain, and at the same time have high safety and good clinical promotion value.

[0034] 2. The external preparation provided by the present invention has obvious advantages over other oral preparations, such as good efficacy and fewer side effects. DETAILED DESCRIPTION

[0035] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Example 1

[0037] This embodiment provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, the raw materials of which are: 8g of rhubarb, 22g of sophora flavescens, 10g of red peony root, 16g of phellodendron, 15g of wild chrysanthemum, 12g of atractylodes, 12g of coptis slices, and 7g of liquorice.

[0038] The preparation method of the Chinese medicine composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0039] Example 2

[0040] This embodiment provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, the raw materials of which are: 10g of rhubarb, 20g of sophora flavescens, 10g of red peony root, 15g of phellodendron, 15g of wild chrysanthemum, 10g of atractylodes, 15g of coptis slices, and 6g of liquorice.

[0041] The preparation method of the Chinese medicine composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0042] Example 3

[0043] This embodiment provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, the raw materials of which are: 10g of rhubarb, 16g of sophora flavescens, 12g of red peony root, 14g of phellodendron, 15g of wild chrysanthemum, 8g of atractylodes, 18g of coptis slices, and 6g of liquorice.

[0044] The preparation method of the Chinese medicine composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0045] Example 4

[0046] This embodiment provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, the raw materials of which are: 8g of rhubarb, 25g of sophora flavescens, 10g of red peony root, 12g of phellodendron, 12g of wild chrysanthemum, 10g of atractylodes, 12g of coptis slices, and 8g of liquorice.

[0047] The preparation method of the Chinese medicine composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0048] Example 5

[0049] This embodiment provides a traditional Chinese medicine composition for treating skin inflammation caused by damp heat, the raw materials of which are: 12g of rhubarb, 18g of sophora flavescens, 8g of red peony root, 18g of phellodendron, 18g of wild chrysanthemum, 8g of atractylodes, 15g of coptis slices, and 5g of liquorice.

[0050] The preparation method of the Chinese medicine composition comprises: weighing various medicinal materials according to the weight ratio, mixing, and then crushing and passing through a 240 sieve.

[0051] Test Example 1

[0052] This test example is used to illustrate the clinical effect of the Chinese medicine composition for treating skin inflammation caused by damp heat provided by the embodiment of the present invention.

[0053] 1. General Information

[0054] 86 patients with anal eczema diagnosed in our outpatient clinic were selected as the research subjects. Among them: 48 males and 38 females, aged 25-65 years, with a course of 1 month to 2 years, symptoms: anal itching, especially at night, accompanied by moisture, exudation, and pain; anal examination showed moisture and exudation in the anal and perineal areas, redness and brittleness of the skin, skin cracking, and obvious tenderness. The patients were randomly divided into two groups, treatment group 1 and treatment group 2, 43 people / group. There was no statistically significant difference in gender, age, and course of disease between the two groups (P>0.05), and they were comparable.

[0055] 2. Methods

[0056] Treatment Group 1 was treated with the Chinese medicine composition of Example 2, and Treatment Group 2 was treated with the Chinese medicine composition of Example 5.

[0057] Usage: On the second day after surgery, first clean the wound surface of the patient with a sterilized dry cotton ball, and then evenly spray the Chinese medicine composition of the embodiment of the present invention on the wound surface, once in the morning and once in the evening, and 7 days is a course of treatment.

[0058] 3. Observation methods and efficacy determination

[0059] It is implemented in accordance with the provisions of the "Diagnostic Criteria for Anal Eczema".

[0060] Cure: The symptoms of perianal itching disappeared, there were no cracks, exudation, pain or moisture in the perianal skin, and the skin elasticity increased compared to before.

[0061] Markedly effective: The symptoms of perianal itching were significantly improved, with occasional itching and moisture around the anus. There was no chapped or painful skin, and the skin color gradually returned to normal.

[0062] Effective: Symptoms and skin lesions were improved.

[0063] Ineffective: No significant improvement in symptoms.

[0064] 4. Results

[0065] The treatment cycle was 7 days. After the treatment, the comparison results of the efficacy between the two groups were shown in 1.

[0066] Table 1

[0067] Group cure Significant effect efficient invalid Total Effectiveness Treatment Group 1 18 17 7 1 97.67％ Treatment Group 2 16 15 9 3 93.02％

[0068] The results show that the Chinese medicine composition provided by the embodiment of the present invention can significantly improve symptoms such as perianal itching, swelling and pain, promote wound healing, and prevent further skin damage, and has excellent therapeutic effects. At the same time, all patients were observed, and no recurrence or skin lesions returned to normal after drug withdrawal, indicating that the Chinese medicine composition provided by the embodiment of the present invention is highly safe and worthy of clinical promotion.

[0069] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A Chinese medicine composition for treating skin inflammation caused by damp heat, characterized in that: The Chinese medicine composition comprises, by weight: 8-12 parts of rhubarb, 15-25 parts of sophora flavescens, 8-12 parts of red peony root, 12-18 parts of phellodendron, 12-18 parts of wild chrysanthemum, 8-12 parts of atractylodes, 12-18 parts of coptis slices and 5-8 parts of liquorice.

2. The Chinese medicine composition for treating skin inflammation caused by damp heat according to claim 1, characterized in that: The Chinese medicine composition comprises, by weight: 10 parts of rhubarb, 20 parts of sophora flavescens, 10 parts of red peony root, 15 parts of phellodendron, 15 parts of wild chrysanthemum, 10 parts of atractylodes, 15 parts of coptis slices and 6 parts of liquorice.

3. The Chinese medicine composition for treating skin inflammation caused by damp heat according to claim 1, characterized in that: The dosage form of the composition is an external preparation.

4. The Chinese medicine composition for treating skin inflammation caused by damp heat according to claim 3, characterized in that: The external preparation is a powder.

5. The Chinese medicine composition for treating skin inflammation caused by damp heat according to claim 3, characterized in that: The skin inflammation includes perianal eczema.

6. A method for preparing the Chinese medicine composition for treating skin inflammation caused by damp heat as claimed in claim 1, characterized in that: Weigh each medicinal material according to the weight ratio, mix them, and then crush and sieve them.

7. The method according to claim 6, characterized in that The sieved particle size is 200-300 meshes.