Novel traditional Chinese medicine compound for preventing and treating anxiety insomnia as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a novel traditional Chinese medicine compound for preventing and treating anxiety insomnia as well as a preparation method and application thereof. The traditional Chinese medicine compound for preventing and treating anxiety insomnia comprises the following raw materials: 9g of cassia twig, 15g of white paeony root, 24g of crude dragon bone, 24g of raw oyster, 24g of fried spina date seed, 12g of lophatherum gracile, 24g of poria cocos, 24g of vinegar tortoise shell, 6g of ginger and 5 Chinese dates. The traditional Chinese medicine compound has remarkable curative effects on anxiety disorder, insomnia, somatic symptoms and the like, is sweet and mild in traditional Chinese medicine taste, and avoids body qi consumption and yin impairment or other adverse effects caused by over-dry and over-pungent medicine properties. All the components of the traditional Chinese medicine compound are natural components, and the traditional Chinese medicine compound is free of any hormone component, can be absorbed by a human body more easily, does not cause burden to liver and kidney, and is high in safety.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a new traditional Chinese medicine compound for preventing and treating anxiety-induced insomnia, and a preparation method and application thereof. Background Art

[0002] Anxiety insomnia is a common type of insomnia, with the coexistence of anxiety and insomnia as the main clinical manifestations, and is a comorbidity of insomnia and neuropsychiatric diseases. The "Expert Consensus on the Diagnosis and Treatment of Insomnia with Depression and Anxiety in Chinese Adults" (2020) points out that insomnia and anxiety often coexist. Patients are prone to anxiety symptoms due to long-term insomnia, and the emergence of anxiety will contribute to patients' misperception of insomnia, causing long-term insomnia. Therefore, the relationship between insomnia and anxiety is complicated and can be roughly divided into the following categories: insomnia with anxiety symptoms, comorbidity of insomnia and anxiety disorders, and physical illness with insomnia and anxiety symptoms. Epidemiological studies have shown that 40%-92% of insomnia symptoms are caused by mental illness. Patients with insomnia and anxiety account for 20%-30%. Although insomnia is often comorbid with anxiety, it has relatively independent and superimposed characteristics. Insomnia is an independent risk factor for anxiety, and vice versa.

[0003] At present, the treatment goal is to control insomnia and anxiety symptoms as early as possible, increase effective sleep time and (or) improve sleep quality; relieve and eliminate anxiety symptoms, reduce residual symptoms, prevent relapse and recurrence; reduce the impact of insomnia and anxiety on physical health, improve treatment compliance, improve quality of life, reduce and eliminate the risk of comorbidities, and avoid the negative effects of drug intervention. Western medicine treatment mainly includes benzodiazepines such as alprazolam, lorazepam, diazepam, as well as anti-anxiety and depression drugs such as melatonin, selective 5-HT reuptake inhibitors, and selective 5-HT and norepinephrine reuptake inhibitors. However, due to the side effects of these drugs such as increased risk of falling, weight gain, and dependence, many patients are reluctant to take medication. Traditional Chinese medicine has unique advantages in the diagnosis and treatment of such diseases, and there are almost no side effects. Traditional Chinese medicine believes that anxiety insomnia belongs to the categories of "insomnia", "depression", "visceral agitation", "lily disease", etc., and believes that it is mainly due to the heart, and the main pathogenesis is the internal disturbance of evil spirits, restlessness, and disharmony between body and spirit. Currently, there are many Chinese patent medicines for treating this disease in clinical practice, such as Zaoren Anshen Capsules and Tianmeng Oral Liquid.

[0004] Western medicine treatment for anxiety insomnia uses drugs for insomnia and anxiety symptoms separately, resulting in multiple types of drugs for patients, long medication cycles, and large adverse reactions. It often causes patients to gain weight, have many residual symptoms the next day, and have dystonia, increase the risk of falling, poor patient compliance, and is difficult to cure. In terms of traditional Chinese medicine treatment, each doctor combines his own experience, has a variety of syndromes, and different drug compositions. This disease is complex, with diverse clinical manifestations, both physical and mental illness, and is difficult to regulate comprehensively, and the effect is slow. Summary of the invention

[0005] The purpose of the present invention is to provide a new Chinese medicinal compound for preventing and treating anxiety-related insomnia and its preparation method and application according to the deficiencies of the prior art.

[0006] The invention provides a novel Chinese medicinal compound for preventing and treating anxiety-induced insomnia. The Chinese medicinal compound is prepared from cassia twig, white peony root, raw dragon bone, raw oyster, stir-fried spiny jujube seed, light bamboo leaf, tuckahoe, vinegar tortoise shell, ginger and jujube.

[0007] Furthermore, the Chinese herbal compound for preventing and treating anxiety-related insomnia is made from the following raw materials: 7-11g of cinnamon twig, 12-18g of white peony root, 20-28g of raw dragon bone, 20-28g of raw oyster, 20-28g of stir-fried spiny jujube kernel, 10-14g of loblolly leaf, 20-28g of poria, 20-28g of vinegar tortoise shell, 4-8g of ginger and 3-7 jujubes.

[0008] Furthermore, the Chinese medicinal compound for preventing and treating anxiety-related insomnia comprises the following raw materials in parts by weight:

[0009] 9g of cinnamon twig, 15g of white peony root, 24g of raw dragon bone, 24g of raw oyster, 24g of stir-fried sour jujube kernel, 12g of light bamboo leaf, 24g of poria, 24g of vinegar tortoise shell, 6g of ginger and 5 jujubes.

[0010] The preparation method of the Chinese medicinal compound for preventing and treating anxiety-induced insomnia is as follows: various medicinal materials are mixed, soaked in water, boiled, filtered, and the filtrate is combined to obtain the Chinese medicinal compound decoction for preventing and treating anxiety-induced insomnia.

[0011] Furthermore, the preparation method of the present invention is as follows: soak each medicinal material for 30-40 minutes, decoct the medicine with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 15-20 minutes each time, concentrate the filtrate to 100 ml, combine the filtrate, and obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0012] Furthermore, the preparation of the Chinese herbal compound for preventing and treating anxiety-related insomnia is a decoction, pill, gel, tablet, mixture, capsule, granule, powder or paste.

[0013] The present invention provides use of the traditional Chinese medicine compound for preventing and treating anxiety-induced insomnia in preparing a medicine for preventing or treating anxiety-induced insomnia.

[0014] There are a large number of records of diseases similar to anxiety and insomnia in TCM literature. For example, the descriptions of "women's visceral agitation", "lily disease", "fox-induced disease", "plum pit qi" and "running pig qi" in "Golden Chamber" should generally be classified as this disease, which is a psychosomatic disease caused by disharmony between body and spirit. In "Treatise on Febrile Diseases", the syndrome of Suanzaoren Decoction is "asthenia and restlessness and insomnia", and the syndrome of Zhizishi Decoction is "after sweating, vomiting and diarrhea, restlessness and insomnia...repeatedly upside down, upset in the heart" can be classified as transient anxiety and insomnia. In addition, "Treatise on Febrile Diseases" records abnormal lying and sleeping in Shaoyin disease more often, among which the abnormal lying and sleeping in Shaoyin heat syndrome is mainly manifested as "restlessness in the heart, unable to lie down" and "restlessness and insomnia". Combined with the patient's clinical symptoms, restlessness at night leads to insomnia, many dreams, and easy awakening; restlessness during the day leads to psychological symptoms such as restlessness, worry, tension, and somatic symptoms such as dizziness, bloating, palpitations, and chest tightness, which puts forward "evil disturbing the mind and disharmony between body and spirit" as the main pathogenesis.

[0015] In the prescription of the present invention, cinnamon twig is pungent and warm, warms and promotes yang qi, promotes qi and relieves depression; white peony root is bitter and flat, nourishes yin and harmonizes the ying, and the two are matched to harmonize yin and yang, and promote qi. Dragon bone and oyster are heavy and calm the mind, calm the liver and suppress yang, and astringe and consolidate. The four medicines are combined to harmonize the ying and wei, suppress yang and astringe. Light bamboo leaves can clear the heart and calm the mind, clear heat and relieve restlessness, Poria can strengthen the spleen and resolve phlegm, calm the mind and calm the mind, tortoise shell can nourish yin and suppress yang, and communicate the heart and kidney, stir-fried sour jujube seeds can soften the liver, nourish the heart, and calm the mind, ginger and jujube can nourish the middle and warm the body, and together they can play the role of clearing heat and calming the mind, resolving phlegm and calming the mind, and regulating both the body and the spirit.

[0016] The Chinese medicine compound of the present invention is based on "evil qi internal disturbance, restlessness, and disharmony of body and spirit" as the main pathogenesis, and is treated by clearing away heat and calming the mind, resolving phlegm and calming the mind, and regulating both body and spirit. It focuses on clearing heat, resolving phlegm, calming the mind, and calming the mind to achieve the effects of regulating the mind and body and achieving both body and spirit. The present invention is designed for the restlessness and disharmony of body and spirit in anxiety insomnia. The Chinese medicine compound of the present invention complies with the compatibility principle of Chinese medicine, has a small dosage of compatible drugs, is safe and non-toxic, has no incompatibility taboos, no dietary taboos, is convenient in dosage, has definite efficacy, is suitable for long-term use by patients, and a treatment cycle is 14 days.

[0017] Compared with the prior art, the present invention has the following advantages:

[0018] (1) The Chinese medicinal compound of the present invention is targeted at anxiety-related insomnia and has significant therapeutic effects on anxiety disorders, insomnia, somatization symptoms, etc.

[0019] (2) The Chinese medicine compound of the present invention is mostly sweet, mild and bland, thus avoiding the body's loss of qi and yin or other adverse effects caused by excessive dryness or spiciness of the medicine.

[0020] (3) All ingredients of the Chinese medicine compound of the present invention are natural ingredients, without any hormone components, and are more easily absorbed by the human body without causing any burden on the liver and kidneys.

[0021] (4) The Chinese medicine compound of the present invention takes both deficiency and excess into consideration, and focuses on clearing away heat and resolving phlegm, and calming the mind and tranquilizing the nerves. Therefore, the dosage can be flexibly adjusted according to the different pathogenesis of the patient. The efficacy can be enhanced by the principle of the original prescription of dredging the qi mechanism, calming the mind and tranquilizing the nerves, without damaging the body's positive energy. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 Comparison of sleep latency in each group and comparison with the model control group. * P<0.05, ** P<0.01; compared with the Example 1 group, # P<0.05, ## P<0.01.

[0023] Figure 2 Comparison of sleep duration in each group, compared with the model control group, * P<0.05, ** P<0.01; compared with the Example 1 group, # P<0.05.

[0024] Figure 3 Comparison of HAMA scores between the two groups, compared with the group before treatment, * P<0.05, compared with the control group after treatment, # P<0.05.

[0025] Figure 4 The PSQI scores of the two groups were compared with those before treatment. * P<0.05, compared with the control group after treatment, # P<0.05. DETAILED DESCRIPTION

[0026] The technical solution of the present invention is further described in detail below in conjunction with the accompanying drawings of the specification, but the protection scope of the present invention is not limited to the following.

[0027] Example 1

[0028] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 9g of cinnamon twig, 15g of white peony root, 24g of raw dragon bone, 24g of raw oyster, 24g of stir-fried spiny jujube kernel, 12g of light bamboo leaf, 24g of poria, 24g of vinegar tortoise shell, 6g of ginger and 5 jujubes.

[0029] Soak each medicinal material for 35 minutes, decoct with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 20 minutes each time, concentrate the filtrate to 100 ml, combine the filtrates to obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0030] Example 2

[0031] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 7g of cassia twig, 18g of white peony root, 25g of raw dragon bone, 28g of raw oyster, 20g of stir-fried spiny jujube kernel, 14g of light bamboo leaf, 28g of poria, 20g of vinegar tortoise shell, 4g of ginger and 7 jujubes.

[0032] Soak each medicinal material for 30 minutes, decoct with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 15 minutes each time, concentrate the filtrate to 100 ml, combine the filtrates to obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0033] Example 3

[0034] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 11g of cassia twig, 12g of white peony root, 20g of raw dragon bone, 20g of raw oyster, 28g of stir-fried spiny jujube kernel, 10g of light bamboo leaf, 20g of poria, 28g of vinegar tortoise shell, 8g of ginger and 3 jujubes.

[0035] Soak each medicinal material for 40 minutes, decoct with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 20 minutes each time, concentrate the filtrate to 100 ml, combine the filtrates to obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0036] Example 4

[0037] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 10g of cassia twig, 15g of white peony root, 22g of raw dragon bone, 26g of raw oyster, 28g of stir-fried spiny jujube kernel, 10g of light bamboo leaf, 23g of poria, 28g of vinegar tortoise shell, 6g of ginger and 5 jujubes.

[0038] Soak each medicinal material for 35 minutes, decoct with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 15 minutes each time, concentrate the filtrate to 100 ml, combine the filtrates to obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0039] Example 5

[0040] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 8g of cassia twig, 16g of white peony root, 20g of raw dragon bone, 28g of raw oyster, 20g of stir-fried spiny jujube kernel, 12g of light bamboo leaf, 28g of poria, 25g of vinegar tortoise shell, 7g of ginger and 6 jujubes.

[0041] Soak each medicinal material for 40 minutes, decoct with purified water, decoct each dose of medicine twice, add 500 ml of purified water each time, decoct for 20 minutes each time, concentrate the filtrate to 100 ml, combine the filtrates to obtain a traditional Chinese medicine compound decoction for preventing and treating anxiety-induced insomnia.

[0042] Comparative Example 1

[0043] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 9g of cinnamon twig, 15g of white peony root, 24g of raw dragon bone, 24g of raw oyster, 24g of cypress seed, 12g of light bamboo leaf, 24g of poria, 24g of buffalo horn, 6g of ginger and 5 jujubes.

[0044] The preparation method is the same as Example 1.

[0045] Comparative Example 2

[0046] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 13g of cassia twig, 21g of white peony root, 33g of raw dragon bone, 33g of raw oyster, 33g of stir-fried spiny jujube kernel, 33g of vinegar tortoise shell, 8g of ginger and 6 jujubes.

[0047] The preparation method is the same as Example 1.

[0048] Comparative Example 3

[0049] A traditional Chinese medicine compound for preventing or treating anxiety-related insomnia is prepared from the following raw materials: 12g of cassia twig, 10g of white peony root, 20g of raw dragon bone, 20g of raw oyster, 30g of stir-fried spiny jujube kernel, 8g of light bamboo leaf, 30g of poria, 28g of vinegar tortoise shell, 6g of ginger and 5 jujubes.

[0050] The preparation method is the same as Example 1.

[0051] Efficacy Example 1 Experimental study on the effect of the Chinese herbal compound of the present invention on anxiety-induced insomnia

[0052] Chlorophenylalanine, as an inhibitor of tryptophan hydrogenase, is a commonly used drug for establishing insomnia models. It can disrupt the day-night balance and cause insomnia by reducing the production of 5-HT.

[0053] 1. Establishment of insomnia rat model

[0054] 56 SPF SD rats, male, weighing (180±20) g, were fed with free access to water and food, and the room temperature was maintained at 20-25°C.

[0055] Eight rats were selected as the blank control group, and the rest of the rats were used for modeling. The modeling method was: intraperitoneal injection of 350 mg / kg of chlorophenylalanine suspension once a day for 3 consecutive days. At this time, the total sleep time of the rats decreased, the daytime activity increased, the circadian rhythm was disordered, and the fur was dry and shriveled, which was consistent with the general manifestations of chlorophenylalanine insomnia. The subsequent sodium pentobarbital synergistic sleep experiment further proved that the modeling was successful.

[0056] The modeled rats were randomly divided into 6 groups according to their body weight, with 8 rats in each group, namely, model control group, Example 1 group, Example 2 group, comparative example 1 group, comparative example 2 group, and comparative example 3 group.

[0057] The Example 1 group was gavaged with 5.5 g / kg of the Example 1 decoction. The Example 2 group was gavaged with 5.5 g / kg of the Example 2 decoction. The Comparative Example 1 group was gavaged with 5.5 g / kg of the Comparative Example 1 decoction. The Comparative Example 2 group was gavaged with 5.5 g / kg of the Comparative Example 2 decoction. The Comparative Example 3 group was gavaged with 5.5 g / kg of the Comparative Example 3 decoction. Rats in the blank control group and the model control group were gavaged with an equal volume of normal saline at a dose of 10 mL / kg. The drug was administered once a day. The drug was administered continuously for 7 days.

[0058] 2. Index detection

[0059] Pentobarbital sodium synergistic sleep experiment

[0060] Two hours after the last administration, rats in each group were intraperitoneally injected with 38 mg / kg sodium pentobarbital, and the sleep latency (the time from injection of sodium pentobarbital to the disappearance of righting reflex) and sleep duration (the time from the disappearance of righting reflex to the recovery) were recorded. The criterion for the disappearance of righting reflex was lying in the abdomen facing upward for more than 1 min.

[0061] 3. Statistical methods

[0062] ˉ

[0063] Graphpad Prism 9.0 software was used for data processing. The measured data were expressed as mean ± standard deviation (x ± s). One-way analysis of variance was used for comparison among multiple groups, and SNK-q was used for pairwise comparison among groups. P < 0.05 was considered statistically significant.

[0064] 4. Experimental Results

[0065] 4.1 Effects on sleep latency in insomnia rats

[0066] Compared with the model control group, the sleep latency of rats in Example 1 and Example 2 groups was shortened.

[0067] Compared with the comparative examples 1-3, the Example 1 group had significant differences in improving the sleep latency. Figure 1 .

[0068] 4.2 Effects on sleep duration in insomnia rats

[0069] Compared with the model control group, the sleep duration of rats in Example 1 and Example 2 groups was prolonged.

[0070] Compared with the comparative examples 1-3, the example 1 group had a significant difference in extending the sleep duration. Figure 2 .

[0071] The Chinese medicinal compound of the present invention shortens the sleep latency of chlorophenylalanine insomnia rats, prolongs the sleep duration, and significantly improves the insomnia symptoms caused by chlorophenylalanine.

[0072] Clinical example: Observation on the therapeutic effect of the Chinese herbal compound of the present invention on anxiety-induced insomnia

[0073] 1. Materials and Methods

[0074] 1. Clinical data

[0075] The 80 patients with anxiety-related insomnia who entered this study were randomly divided into a control group and an experimental group of 40 people each. The control group had 22 males and 18 females with an average age of (56.19±5.26) years old; the observation group had 19 males and 21 females with an average age of (58.34±3.52) years old. The two groups were comparable in age and gender.

[0076] 2. Diagnostic criteria

[0077] Western medicine: Refer to the "Classification and Diagnostic Criteria of Mental Disorders of the Chinese Psychiatric Society" for the definition of sleep disorders, including the presence of sleep problems, poor sleep quality, difficulty falling asleep, frequent dreams and easy awakening, daytime fatigue, decreased concentration, dizziness, and fatigue; the total score of the Hamilton Anxiety Rating Scale is >14 points, and the Pittsburgh Sleep Quality Index score is >7 points; the duration is at least 1 month.

[0078] Traditional Chinese Medicine: Refer to the "Guidelines for Clinical Research of New Chinese Medicines" issued by the Ministry of Health of China and the "Practical Diagnosis of Traditional Chinese Medicine" published by the People's Medical Publishing House to determine the diagnostic criteria for "insomnia": the presence of frequent inability to obtain normal sleep: difficulty falling asleep, waking up easily after falling asleep, and difficulty continuing to sleep after waking up.

[0079] 3. Exclusion criteria

[0080] ① Those with incomplete medical records and those who do not cooperate with relevant treatment measures; ② Those who have allergic reactions to the drugs involved in the study; ③ Those with other serious diseases.

[0081] 4. Inclusion criteria

[0082] ① Those who meet the above-mentioned Chinese and Western medicine diagnostic criteria; ② Aged 18-70 years old; ③ Have not taken any medication for insomnia in the past week. ④ The patient and his family members have informed consent and signed the informed consent form.

[0083] 5. Treatment Methods

[0084] Control group: Zopiclone tablets, 3 mg / time, once a day, orally.

[0085] Observation group: Orally take the decoction of Example 1, one dose per day, divided into two doses.

[0086] One course of treatment is 14 days, and there are 3 courses in total, totaling 6 weeks.

[0087] During the trial medication period, it is not allowed to use other drugs or methods to treat anxiety-related insomnia, and lifestyle and exercise habits are not changed.

[0088] 6.Indicator observation

[0089] (1) Clinical efficacy evaluation criteria: Clinical efficacy was evaluated according to the "Guidelines for Clinical Research of New Chinese Medicines": marked effect means that sleep time returned to normal (≥6h) and the patient felt energetic after waking up; effective means that sleep quality improved and sleep time was >3h; ineffective means that sleep time and sleep quality did not improve at all. Total effective rate = (marked effect + effective) cases / total cases × 100%.

[0090] (2) Hamilton Anxiety Rating Scale (HAMA) and Pittsburgh Sleep Quality Inventory (PSQI) scores: The HAMA scale was used to assess anxiety before and after treatment. It includes 14 items. Each item is scored from asymptomatic to severe according to the severity of the symptoms. The total score is 0, 1, 2, 3, and 4 points, with a total score of 56 points. The higher the score, the more severe the anxiety symptoms. The PSQI scale was used to assess sleep quality. It includes 19 self-assessment items and 5 other-assessment items. The total score is 21 points. The higher the score, the worse the sleep quality.

[0091] 7. Statistical methods

[0092] SPSS 22.0 software was used for data processing, and the data were expressed as mean ± standard deviation. The data of each group were subjected to normal distribution test and variance homogeneity test, and the inter-group comparison was performed with one-way analysis of variance, with P < 0.05 as the difference being statistically significant.

[0093] 2. Results

[0094] 1. Comparison of clinical efficacy

[0095] The total effective rate of the observation group was better than that of the control group. The results are shown in Table 1.

[0096] Table 1 Comparison of clinical efficacy between the two groups

[0097]

[0098]

[0099] 2. HAMA and PSQI scores

[0100] Depend on Figure 3 , Figure 4The results showed that before treatment, there was no statistically significant difference in HAMA and PSQI scores between the two groups of patients; after treatment, HAMA and PSQI scores between the two groups of patients decreased significantly, and the scores of the observation group were significantly lower than those of the control group, with a significant difference.

[0101] The Chinese medicinal compound of the present invention reduces the HAMA and PSQI scores of patients with anxiety-related insomnia, and effectively improves the anxiety state and sleep quality of the patients.

[0102] The above embodiments are merely examples for clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description, and the obvious changes or modifications derived therefrom are still within the scope of protection of the present invention.

Claims

1. A Chinese medicinal compound for preventing and treating anxiety-related insomnia, characterized in that: The Chinese medicinal compound for preventing and treating anxiety-induced insomnia is prepared from the following raw materials: 7-11g of cassia twig, 12-18g of white peony root, 20-28g of raw dragon bone, 20-28g of raw oyster, 20-28g of stir-fried spiny jujube kernel, 10-14g of lophatherum gracile, 20-28g of poria, 20-28g of vinegar tortoise shell, 4-8g of ginger and 3-7 jujubes.

2. The Chinese medicinal compound for preventing and treating anxiety-related insomnia according to claim 1, characterized in that: The Chinese medicinal compound for preventing and treating anxiety-induced insomnia comprises the following raw materials: 9g of cinnamon twig, 15g of white peony root, 24g of raw dragon bone, 24g of raw oyster, 24g of stir-fried spiny jujube kernel, 12g of light bamboo leaf, 24g of poria, 24g of vinegar tortoise shell, 6g of ginger and 5 jujubes.

3. The Chinese medicinal compound for preventing and treating anxiety-related insomnia according to any one of claims 1 or 2, characterized in that: The preparation method of the Chinese medicinal compound for preventing and treating anxiety-induced insomnia is as follows: various medicinal materials are mixed, soaked in water, boiled, filtered, and the filtrate is combined to obtain the Chinese medicinal compound decoction for preventing and treating anxiety-induced insomnia.

4. The Chinese medicinal compound for preventing and treating anxiety-related insomnia according to any one of claims 1 or 2, characterized in that: The preparation method of the Chinese herbal compound for preventing and treating anxiety-induced insomnia is as follows: soaking various medicinal materials for 30-40 minutes, decocting the medicine with purified water, decocting each dose of medicine twice, adding 500 ml of purified water each time, decocting each time for 15-20 minutes, concentrating the filtrate to 100 ml, combining the filtrates, and obtaining the Chinese herbal compound decoction for preventing and treating anxiety-induced insomnia.

5. The Chinese medicinal compound for preventing and treating anxiety-related insomnia according to any one of claims 1 or 2, characterized in that: The preparation of the traditional Chinese medicine compound for preventing and treating anxiety-related insomnia is a decoction, a pill, a gel, a tablet, a mixture, a capsule, a granule, a powder or an ointment.

6. Use of the Chinese medicinal compound for preventing and treating anxiety-related insomnia according to any one of claims 1 or 2 in the preparation of a drug for preventing or treating anxiety-related insomnia.

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