Traditional Chinese medicine composition and traditional Chinese medicine preparation for promoting recovery of vitiligo and preparation method of traditional Chinese medicine preparation

Abstract

The invention discloses a traditional Chinese medicine composition for promoting vitiligo recovery, a traditional Chinese medicine preparation and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from the following components in parts by weight: 60 to 90 parts of radix notoginseng, 60 to 80 parts of fructus psoraleae, 60 to 90 parts of radix astragali seu hedysari, 60 to 90 parts of rhizoma polygonati, 60 to 90 parts of fructus tribuli, 60 to 90 parts of radix salviae miltiorrhizae, 100 to 140 parts of caulis spatholobi, 60 to 90 parts of radix codonopsis, 60 to 90 parts of rhizoma atractylodis macrocephalae, 60 to 90 parts of radix bupleuri and 15 to 35 parts of liquorice root. The traditional Chinese medicine composition has a good promoting effect on the rehabilitation of leucoderma patients, and effectively solves the problem of poor curative effect of medicines in the prior art.

Description

Technical Field

[0001] The present invention belongs to the technical field of Chinese medicine compositions, and in particular relates to a Chinese medicine composition for promoting recovery of vitiligo, a Chinese medicine preparation and a preparation method thereof. Background Art

[0002] Vitiligo is an acquired depigmented skin disease caused by the destruction of melanocytes. Its clinical manifestations are depigmented spots on the skin or mucous membranes, which may involve hair follicles, accompanied by local whitening of hair. Its incidence rate is increasing year by year. The disease is prone to occur in exposed and rubbed areas, and is more common in spring and summer. There is no age or gender difference in the onset of the disease. Studies have shown that multiple factors contribute to the occurrence of vitiligo, which can be induced by anxiety, depression, environment, trauma, exposure to the sun, etc., but the specific mechanism is not yet fully understood and may be related to genetic, immune, oxidative stress, sun exposure, and mental factors. Vitiligo is easy to diagnose, difficult to treat, has a protracted course, and is prone to recurrence. The disease seriously damages the patient's appearance and has a great negative impact on their normal life, social life, and even mental health.

[0003] At present, Western medicine has a rich variety of treatment methods and many options. Topical medications, glucocorticoids and phototherapy are still the first-line options for treating vitiligo. However, there is no specific treatment for this disease, the treatment effect is limited, and the individual treatment response varies greatly. Therefore, it is particularly important to find better, safer and more effective treatment methods. Summary of the invention

[0004] In view of the above-mentioned deficiencies in the prior art, the present invention provides a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a preparation method thereof for promoting the recovery of vitiligo. The traditional Chinese medicine composition has a good promoting effect on promoting the recovery of patients in the recovery period of vitiligo, and effectively solves the problem of poor efficacy of drugs in the prior art.

[0005] To achieve the above purpose, the technical solution adopted by the present invention to solve the technical problem is:

[0006] A traditional Chinese medicine composition for promoting the recovery of vitiligo comprises the following components in parts by weight: 60-90 parts of Panax notoginseng, 60-80 parts of Psoralea corylifolia, 60-90 parts of Astragalus, 60-90 parts of Polygonatum sibiricum, 60-90 parts of Tribulus terrestris, 60-90 parts of Salvia miltiorrhiza, 100-140 parts of Millettia reticulata, 60-90 parts of Codonopsis pilosula, 60-90 parts of Atractylodes macrocephala, 60-90 parts of Bupleurum chinense and 15-35 parts of Licorice.

[0007] Further, the invention comprises the following components in parts by weight: 70-80 parts of Panax notoginseng, 70-80 parts of Psoralea corylifolia, 70-80 parts of Astragalus membranaceus, 70-80 parts of Polygonatum sibiricum, 75-85 parts of Tribulus terrestris, 75-85 parts of Salvia miltiorrhiza, 120-130 parts of Millettia reticulata, 70-80 parts of Codonopsis pilosula, 75-85 parts of Atractylodes macrocephala, 75-85 parts of Bupleurum chinense and 20-30 parts of Licorice.

[0008] Further, the following components are included in parts by weight: 80 parts of Panax notoginseng, 70 parts of Psoralea corylifolia, 70 parts of Astragalus membranaceus, 80 parts of Polygonatum sibiricum, 85 parts of Tribulus terrestris, 75 parts of Salvia miltiorrhiza, 130 parts of Millettia reticulata, 80 parts of Codonopsis pilosula, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

[0009] Further, the invention comprises the following components in parts by weight: 70 parts of Panax notoginseng, 80 parts of Psoralea corylifolia, 80 parts of Astragalus membranaceus, 70 parts of Polygonatum sibiricum, 75 parts of Tribulus terrestris, 85 parts of Salvia miltiorrhiza, 120 parts of Millettia spatholobi, 70 parts of Codonopsis pilosula, 75 parts of Atractylodes macrocephala, 85 parts of Bupleurum chinense and 30 parts of Licorice.

[0010] Furthermore, the polygonatum is steamed polygonatum.

[0011] Furthermore, the Tribulus terrestris is fried Tribulus terrestris.

[0012] A traditional Chinese medicine preparation for promoting recovery of vitiligo, comprising the above-mentioned traditional Chinese medicine composition.

[0013] Furthermore, Chinese medicine preparations include pills, tablets, granules, powders and mixtures.

[0014] Furthermore, the method comprises the following steps: the eleven herbs are decocted twice with water, the decoctions are combined, concentrated to 70-80% of the target volume, filtered, and then the water is added to the target volume, filled, sterilized, and the product is obtained.

[0015] Furthermore, 9-11 times the weight of the medicinal material is added with water for the first time, and the decoction time is 1-3 hours. The second time, 7-9 times the weight of the medicinal material is added with water, and the decoction time is 0.5-1.5 hours.

[0016] The beneficial effects produced by the present invention are:

[0017] In the composition of the present invention, astragalus has the effects of tonifying the middle and replenishing qi, raising yang and consolidating the exterior; psoralea has the effect of tonifying the kidney and assisting the spleen; codonopsis has the effect of tonifying the middle and replenishing qi, strengthening the spleen and nourishing the stomach; polygonatum has the effect of tonifying the kidney and replenishing essence, nourishing the stomach and moistening the intestines; atractylodes has the effect of strengthening the spleen and replenishing qi, stopping sweat and consolidating the exterior; panax notoginseng has the effect of harmonizing the blood circulation and stopping bleeding, unblocking the meridians and removing blood stasis. The above are all monarch drugs, which promote the smooth circulation of qi and blood in the patient's body and directly reach the epidermis through the effects of tonifying the middle and replenishing qi, raising yang and lifting depression, soothing the liver and relieving depression, and promoting blood circulation and removing blood stasis;

[0018] Salvia miltiorrhiza plays the role of promoting blood circulation, removing blood stasis, regulating menstruation and relieving pain, Millettia reticulata plays the role of promoting blood circulation, removing blood stasis and regulating menstruation, and Tribulus terrestris mainly plays the role of pungent and warming to reach the Wei, promoting the flow of hair pores, and opening the skin. The above are all assistant drugs, which are used to assist the main drug to directly reach the affected part of the skin surface and promote recovery.

[0019] Bupleurum has the effect of soothing the liver and relieving the exterior symptoms, and is used to assist Astragalus to lift the sunken middle qi, and is an adjuvant, while Licorice harmonizes the other drugs, and is used as a guiding drug. The Chinese medicinal materials in the prescription of the present invention are mostly warming drugs, and the various medicinal materials cooperate and synergize with each other to promote the circulation of qi and blood in the body, directly reaching the epidermis, and the epidermis is nourished by qi and blood, and the affected area is naturally repaired. DETAILED DESCRIPTION

[0020] In order to make the purpose, technical scheme and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention, that is, the embodiments described are only part of the embodiments of the present invention, rather than all of the embodiments.

[0021] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0022] It should be noted that relational terms such as "first" and "second" are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0023] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0024] Example 1

[0025] A traditional Chinese medicine composition for promoting the recovery of vitiligo, composed of the following components in parts by weight: 60g of Panax notoginseng, 60g of Psoralea corylifolia, 60g of Astragalus membranaceus, 90g of steamed Polygonatum sibiricum, 90g of stir-fried Tribulus terrestris, 60g of Salvia miltiorrhiza, 140g of Millettia reticulata, 90g of Codonopsis pilosula, 90g of Atractylodes macrocephala, 60g of Bupleurum chinense and 15g of Licorice.

[0026] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 9 times the weight of the herbs are added with water, and the decocting time is 1 hour, the second time 7 times the amount of water is added, and the decocting time is 0.5 hour, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0027] Example 2

[0028] A traditional Chinese medicine composition for promoting the recovery of vitiligo, composed of the following components in parts by weight: 90g of Panax notoginseng, 80g of Psoralea corylifolia, 90g of Astragalus membranaceus, 60g of steamed Polygonatum sibiricum, 60g of stir-fried Tribulus terrestris, 90g of Salvia miltiorrhiza, 100g of Millettia reticulata, 60g of Codonopsis pilosula, 60g of Atractylodes macrocephala, 90g of Bupleurum chinense and 35g of Licorice.

[0029] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 11 times the weight of the herbs are added with water, and the decocting time is 3 hours, the second time 9 times the amount of water is added, and the decocting time is 1.5 hours, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0030] Example 3

[0031] A traditional Chinese medicine composition for promoting the recovery of vitiligo, composed of the following components in parts by weight: 80 parts of Panax notoginseng, 70 parts of Psoralea corylifolia, 70 parts of Astragalus membranaceus, 80 parts of steamed Polygonatum sibiricum, 85 parts of stir-fried Tribulus terrestris, 75 parts of Salvia miltiorrhiza, 130 parts of Millettia reticulata, 80 parts of Codonopsis pilosula, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

[0032] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 10 times the weight of the herbs are added with water, and the decocting time is 2 hours, the second time 8 times the amount of water is added, and the decocting time is 1 hour, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0033] Example 4

[0034] A traditional Chinese medicine composition for promoting recovery from vitiligo, composed of the following components in parts by weight: 70 parts of Panax notoginseng, 80 parts of Psoralea corylifolia, 80 parts of Astragalus membranaceus, 70 parts of steamed Polygonatum sibiricum, 75 parts of stir-fried Tribulus terrestris, 85 parts of Salvia miltiorrhiza, 120 parts of Millettia reticulata, 70 parts of Codonopsis pilosula, 75 parts of Atractylodes macrocephala, 85 parts of Bupleurum chinense and 30 parts of Licorice.

[0035] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 11 times the weight of the herbs are added with water, and the decocting time is 3 hours, the second time 7 times the amount of water is added, and the decocting time is 0.5 hours, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0036] Comparative Example 1

[0037] A traditional Chinese medicine composition for promoting recovery of vitiligo, composed of the following components in parts by weight: 80 parts of Panax notoginseng, 70 parts of Psoralea corylifolia, 85 parts of stir-fried Tribulus terrestris, 75 parts of Salvia miltiorrhiza, 130 parts of Millettia reticulata, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

[0038] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eight medicines are decocted twice with water, the first time 10 times the weight of the medicinal materials is added with water, and the decocting time is 2 hours, the second time 8 times the amount of water is added, and the decocting time is 1 hour, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0039] Comparative Example 2

[0040] A traditional Chinese medicine composition for promoting recovery of vitiligo, composed of the following components in parts by weight: 80 parts of Panax notoginseng, 70 parts of Psoralea corylifolia, 70 parts of Astragalus membranaceus, 80 parts of steamed Polygonatum sibiricum, 85 parts of Ephedra sinica, 75 parts of Salvia miltiorrhiza, 130 parts of Angelica sinensis, 80 parts of Codonopsis pilosula, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

[0041] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 10 times the weight of the herbs are added with water, and the decocting time is 2 hours, the second time 8 times the amount of water is added, and the decocting time is 1 hour, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0042] Comparative Example 3

[0043] A traditional Chinese medicine composition for promoting the recovery of vitiligo, composed of the following components in parts by weight: 40 parts of Panax notoginseng, 40 parts of Psoralea corylifolia, 70 parts of Astragalus membranaceus, 80 parts of steamed Polygonatum sibiricum, 85 parts of stir-fried Tribulus terrestris, 35 parts of Salvia miltiorrhiza, 130 parts of Millettia reticulata, 80 parts of Codonopsis pilosula, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

[0044] The above-mentioned traditional Chinese medicine preparation for promoting the recovery of vitiligo is in the form of a mixture, and its preparation method is as follows: the above eleven herbs are decocted twice with water, the first time 10 times the weight of the herbs are added with water, and the decocting time is 2 hours, the second time 8 times the amount of water is added, and the decocting time is 1 hour, the two decoctions are combined, concentrated to 800 ml, filtered, and then water is added to 1000 ml, filled, and sterilized at 105°C for 30 minutes to obtain the product.

[0045] Test example

[0046] 1. General Information

[0047] Patients diagnosed with vitiligo who came to the hospital were aged between 19 and 71 years old;

[0048] 2. Methods

[0049] 2.1 Diagnostic criteria

[0050] The Western medicine diagnostic standards refer to the "Consensus on the Diagnosis and Treatment of Vitiligo (2021 Edition)", which are divided into progressive and stable stages. The disease stage is determined based on the Vitiligo Disease Activity Score (VIDA), clinical characteristics, Wood lamp examination results, and isomorphic reactions.

[0051] (1) Installment

[0052] ①VIDA

[0053] "+4 points" if the original lesions have enlarged or new lesions have appeared in the past 6 weeks;

[0054] "+3 points" if the original lesions have expanded or new lesions have appeared in the past 3 months;

[0055] "+2 points" if the original lesions enlarged or new lesions appeared in the past 6 months;

[0056] "+1 point" if the original skin lesions enlarge or new skin lesions appear within the past year;

[0057] "+0 points" if the skin lesions are stable for at least 1 year;

[0058] Lesions that have been stable for at least 1 year with spontaneous pigmentation are scored as -1 points;

[0059] A VIDA score of 0 indicates a stable stage.

[0060] ②Clinical features: Lesions with unclear edges, inflammatory symptoms such as itching and erythema, confetti-like white spots, tricolor vitiligo or hypopigmented spots can be judged as progressive vitiligo. Lesions that are porcelain white with clear borders or pigmentation at the edges indicate a stable stage.

[0061] ③ Isomorphic reaction: The appearance of white spots within 1 year at the site of skin damage caused by various factors such as physical, chemical, allergic, other inflammatory skin diseases, irritant reactions, treatments, etc. can be judged as progressive vitiligo. No isomorphic reaction for more than 1 year indicates a stable period.

[0062] ④Wood lamp: The area of ​​white spot under Wood lamp is greater than the area estimated by eyes, the border is unclear, and it is grayish white, which can be judged as progressive stage. The area of ​​white spot under Wood lamp is less than the area estimated by eyes, which indicates stable stage.

[0063] (2) Classification

[0064] Segmental type: usually refers to unilateral asymmetric vitiligo that is distributed along the skin area innervated by a certain cutaneous nerve segment (completely or partially matching the skin segment).

[0065] Non-segmental (usual) type: includes the following 5 types: sporadic type: refers to the number of white spots being 2 or more, and the area is less than 50% of the body surface area; generalized type: refers to the area of ​​white spots being greater than 50% of the body surface area; face and neck type: the white spots are limited to the face and neck; acrofacial type: the white spots are limited to the extremities; mucosal type: the white spots are distributed in more than 2 mucosal areas.

[0066] Mixed type: There are both non-segmental and segmental types.

[0067] Or the TCM diagnostic criteria meet the diagnosis of liver depression, qi stagnation and blood stasis in the "Expert Consensus on TCM Treatment of Vitiligo", with the main symptoms of long course of disease, fixed white spots, white hair in white spots, and dark white spots; secondary symptoms: ① irritability; ② chest ribs or lower abdominal distension and pain; ③ women may have premenstrual breast pain; ④ women's menstrual color is dark, there are blood clots or dysmenorrhea; ⑤ lips and nails are purple and dark complexion. Tongue and pulse: dull tongue, tortuous sublingual veins or ecchymosis, deep and thin pulse or astringent. If any two of the five main and secondary symptoms are present at the same time, combined with tongue and pulse, the diagnosis can be made.

[0068] 2.2 Inclusion criteria

[0069] ① Meet the diagnostic criteria of Western medicine; or ② Meet the diagnostic criteria of Traditional Chinese Medicine for Qi stagnation and blood stasis: white patches of a long duration, porcelain white or milky white in color, with clear borders, or irritability, chest rib or lower abdominal distension and pain.

[0070] 2.3 Exclusion criteria

[0071] ① Patients who do not meet the TCM syndrome type are excluded; ② Patients with concurrent autoimmune diseases, cardiovascular diseases, liver and kidney dysfunction, etc.; ③ Allergic constitution; ④ Signs of infection in the skin lesions; ⑤ Patients who have received relevant treatment in the past 2 months; ⑥ Patients who are pregnant or breastfeeding.

[0072] 2.4 Efficacy evaluation criteria

[0073] (1) Clinical efficacy: evaluated according to the Diagnosis and Treatment Standards for Chloasma and Vitiligo (2010 Edition). The white spots completely disappear and the skin color returns to normal, which is considered cured; the white spots mostly disappear and the skin recovery area accounts for 50% or more of the skin lesion area, which is considered markedly effective; the white spots partially disappear and the skin recovery area accounts for 10% to 50%, which is considered effective; the white spots have no obvious changes and the skin recovery area is less than 10%, which is considered ineffective.

[0074] Effective rate (%) = (number of cured patients + number of effective patients + number of effective patients) / total number of patients * 100%

[0075] 2.5 Treatment methods

[0076] The patients diagnosed with vitiligo were randomly divided into 4 groups, with 20 people in each group. Different groups of cases were treated with the compositions of Example 3 and Comparative Examples 1-3, respectively. 200 ml was taken orally, twice a day, for 15 consecutive days. Spicy and irritating foods were not taken during the treatment.

[0077] 3. Efficacy statistics

[0078] Table 1: Efficacy statistics

[0079]

[0080] It can be seen from the data in the above table that after treatment with the preparations in Examples 3 and 4 of the present application, the effective rate is as high as over 85%, proving that the Chinese medicine preparations in the present application have a good therapeutic effect on vitiligo.

[0081] The composition in Comparative Example 1 was compared with the composition in Example 3, and the addition of Astragalus, Polygonatum, and Codonopsis was eliminated. It was found from the therapeutic effect that the therapeutic effect of the composition became worse after the above-mentioned medicinal materials were eliminated. It is speculated that this is because after the elimination, the overall effects of the composition in tonifying the middle and replenishing Qi, raising Yang and consolidating the exterior, strengthening the spleen and nourishing the stomach are weakened, affecting the biochemistry and circulation of Qi and blood in the body, making it impossible for Qi and blood to reach the surface of the skin, thereby affecting the treatment of vitiligo.

[0082] The composition in Comparative Example 2 was compared with the composition in Example 3, and stir-fried Tribulus terrestris was replaced with Ephedra sinica, and Millettia reticulata was replaced with Angelica sinensis. The therapeutic effect showed that after the above-mentioned medicinal materials were removed, the therapeutic effect of the composition became worse. It is speculated that this is because after the replacement, the effects of the composition in promoting blood circulation and removing blood stasis, unblocking the pores, and opening the skin were weakened or disappeared, so that qi and blood could not reach the surface of the skin, affecting the therapeutic effect on vitiligo.

[0083] The composition in Comparative Example 3 was compared with the composition in Example 3, and the dosages of Psoralea corylifolia, Panax notoginseng and Salvia miltiorrhiza were reduced. It was found from the therapeutic effect that the therapeutic effect of the composition became worse after the dosages of the above-mentioned medicinal materials were reduced. It is speculated that the possible reason is that the effects of tonifying the kidney and spleen, promoting blood circulation and removing blood stasis are weakened, affecting the biochemistry and circulation of qi and blood in the body, making it impossible for qi and blood to reach the surface of the skin, thereby affecting the treatment of vitiligo.

[0084] Typical Cases

[0085] Case 1: He Yi, male, 19 years old; Date of visit: July 2024

[0086] Chief complaint: Pale white patches were found on the patient's buttocks without obvious cause one week ago. The patient came to the hospital for treatment today. The patient was depressed, had chest tightness, stomach bloating, flank pain, loss of appetite, pale tongue with white fur, and stringy pulse.

[0087] Examination: The patient had scattered pale white patches on the skin around the right eye, mouth, armpit, buttocks, and right foot. They were painless and itchy, and of different sizes and shapes. The skin fluorescence reaction of the white patches under the Wood's lamp was (+), the boundaries of the white patches were unclear, and the area of ​​the white patches was larger than the visually estimated area.

[0088] Initial diagnosis: Vitiligo

[0089] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0090] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0091] The main complaint of the follow-up visit: No special discomfort after taking the medicine. Melanin islands were formed inside the white spots, and the area was slightly reduced. The border was clear under the Wood lamp, and the area of ​​the white spots under the lamp was equal to the visual area. The chest tightness and stomach distension were improved. The tongue was pale, the tongue coating was white, and the pulse was stringy.

[0092] Case 2: Lv Dan, female, 16 years old. Date of visit: July 2024;

[0093] Chief complaint: The patient had pale white patches behind the left ear and on the left thigh when he was born, but he did not pay much attention to them at first. Later, the area of ​​the white patches gradually expanded, so he came to the hospital for treatment today. The patient was usually in a low mood, had a poor appetite, had a reddish-yellow complexion, a pale tongue, was not thirsty, had a thin white fur, and a stringy pulse.

[0094] Examination: Wood examination revealed scattered white patches on the patient's skin behind the left ear and on the left thigh. The size and shape of the patches were irregular. The fluorescence reaction of the skin at the white patches under the Wood's lamp was (+). The boundaries were not clear, and the area of ​​the white patches was larger than the visually observed area.

[0095] Initial diagnosis: Vitiligo

[0096] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0097] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0098] The main complaint of the follow-up visit: No special discomfort after taking the medicine. The patient has small islands of melanin formed inside the white spot, and the area is slightly reduced. The border is clear under the Wood lamp, and the area of ​​the white spot under the lamp is equal to the visual area. Normal diet, occasional sighing, pale tongue, white fur, and stringy pulse.

[0099] Case 3: Wang Xijuan, female, 37 years old, date of consultation: October 2023;

[0100] Chief complaint: Over 7 years ago, pale white patches of halo nevus type were found on the back skin without obvious cause. Then he went to a hospital in Shanghai for treatment and was diagnosed with "vitiligo". He was treated with topical medication (unknown details) for a period of time, but no obvious effect was seen. Because he failed to persist in the treatment, the white spots later spread to the skin around the eyes, occipital area, armpits, back, right hand and left hip. Later, he went to Nanjing Dermatology Research Institute for treatment and was treated with oral and topical medication (unknown details) for a period of time, but no effect was seen. When he came to the hospital today, his complexion was dull, he had palpitations, shortness of breath, fatigue, pale tongue, and slow pulse.

[0101] Examination: Wood's examination showed scattered white patches on the patient's head, face, right ear and back. The patches varied in size and shape. The white patches showed white fluorescence under the Wood's lamp, with unclear boundaries and a larger area than the visually observed area.

[0102] Initial diagnosis: Vitiligo

[0103] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0104] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0105] The main complaint of the follow-up visit: No special discomfort after taking the medicine. Melanin is produced inside the white spot of the patient, and the area is significantly reduced. The border of the white spot is clear under the Wood lamp, and the area of ​​the white spot under the lamp is equal to the visual area. The patient's face is ruddy, his voice is loud, he is energetic, his tongue is white, his tongue coating is pale, and his pulse is slow.

[0106] Case 4: Wang Jinqin, female, 34 years old, consultation date: November 2020;

[0107] Chief complaint: scattered pale white patches appeared on the skin around the left ear, chest, bilateral armpits, and right groin without obvious cause more than 2 months ago. Today, he came to our hospital for treatment. The patient had fullness in the stomach, stabbing pain, pain in both flanks, which was aggravated by emotional distress, acid swallowing, belching, decreased appetite, pale red tongue, thin white fur, and stringy pulse.

[0108] Examination: Wood's examination: The skin fluorescence reaction of the white spots is (+), and the boundaries of the white spots are not clear.

[0109] Initial diagnosis: Vitiligo

[0110] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0111] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0112] The main complaint of the follow-up visit: No special discomfort after taking the medicine. There are scattered pale white patches on the skin around the left ear, chest, bilateral armpits, and right groin, with different sizes and shapes, and some parts are fused into patches. The skin of the white spots under the Wood's lamp shows a white fluorescent reaction, with clear boundaries, and the area under the lamp is equal to the visual area. Melanin is produced inside the white spots, and the surrounding pigment is darkened. The patient's fullness is relieved, his diet is normal, the pain in both flanks is reduced, and he occasionally has belching and acid swallowing. The tongue is red with white fur and the pulse is stringy.

[0113] Case 5: Xu Chuancheng, male, 11 years old. Date of visit: March 2020;

[0114] Chief complaint: Pale white patches appeared on the skin around the right eye, mouth, armpit, buttocks, and right foot without obvious cause more than 1 year ago. He went to a local hospital for treatment and was given oral and topical medications (unknown details), but the effect was not good. The patient had a sallow complexion, occasional dizziness, and often felt weak, which worsened after exercise. His tongue was pale with white fur, and his pulse was deep, thin, and weak.

[0115] Examination: Wood's examination: Pale white patches are scattered around the right eye, mouth, armpit, buttocks, and right foot, which are painless and of different sizes and shapes. The skin fluorescence reaction of the white spots is (+), and the boundaries of the white spots are unclear.

[0116] Initial diagnosis: Vitiligo

[0117] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0118] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0119] The main complaint of the follow-up visit: No special discomfort after taking the medicine. There are scattered pale white patches on the skin around the right eye, mouth, armpit, buttocks, and right foot, with different sizes and shapes. The skin of the white spots shows white fluorescence reaction under the Wood's lamp, with slightly clear boundaries, and the area under the lamp is slightly larger than the visual area. The patient's face is slightly yellow, dizziness and blurred vision have decreased, fatigue has improved slightly, the tongue is pale with white fur, bowel movements are normal, and the pulse is deep and fine.

[0120] Case 6: Wu Hao, male, 15 years old. Date of visit: November 2020;

[0121] Chief complaint: 6 years ago, there were scattered pale white patches on the skin of the scalp, corners of the eyes, around the nose, around the mouth, abdomen, and elbows without obvious cause. He then went to Peking Union Medical College Hospital for treatment and was diagnosed with "vitiligo". He was given oral and topical medications (unknown details) for more than 2 years of treatment. Later, he was treated at Nanjing Dermatological Research Institute and diagnosed with "vitiligo". He was given oral and topical medications (unknown details), but the effect was poor. He was then referred to Hefei Huaxia Vitiligo Hospital and diagnosed with "vitiligo". He was given phototherapy, medicated bath fumigation, and oral medications (unknown details) for more than 2 years of treatment, and the white spots did not recover. Today, the patient came to the hospital for treatment. The patient had a sallow complexion, loss of appetite, occasional dizziness, and often felt weak, which worsened after exercise. The tongue was pale with white fur, and the pulse was deep and thin.

[0122] Past history: Past health.

[0123] Examination: The patient's scalp, eye corners, nose, mouth, abdomen, elbows have scattered white patches of varying sizes and shapes, some of which are fused into patches, with clear boundaries, flat surface, redness due to friction, and no itching, desquamation, or atrophy. The skin at the white spots shows white fluorescence reaction under WOOD lamp, with clear boundaries, and the area of ​​white spots under Wood lamp is equal to the visually observed area.

[0124] Initial diagnosis: Vitiligo

[0125] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0126] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0127] The main complaint of the follow-up visit: No special discomfort after taking the medicine. The patient's scalp, eye corners, nose, mouth, abdomen, elbows have scattered pale white patches of different sizes and shapes. The skin of the white spots shows white fluorescence reaction under the Wood's lamp, with clear boundaries, and the area under the lamp is equal to the visual area. The patient's complexion is slightly yellow, normal diet, normal bowel movements, slight improvement in fatigue, pale tongue with white fur, and deep pulse.

[0128] Case 7: Tang Jingjing, female, 30 years old, date of consultation: November 2020;

[0129] Chief complaint: 20 years ago, scattered pale white patches appeared on the skin of the lower neck without obvious cause, and no treatment was given. Today, the patient came to the hospital for treatment. He was depressed, tired, sighed from time to time, felt stuffy and uncomfortable in the chest and flanks, had a dark tongue, white fur, and a stringy and slippery pulse.

[0130] Examination: Wood examination showed a patch of white spots on the patient's neck with irregular shape. The skin fluorescence reaction of the white spots under the Wood lamp was (+). The boundaries were not clear and the area of ​​the white spots was larger than the visually observed area.

[0131] Initial diagnosis: Vitiligo

[0132] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0133] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0134] The main complaint of the follow-up visit: No special discomfort after taking the medicine. Melanin islands are formed inside the white spots, and the area is slightly reduced. The border is clear under the Wood lamp, and the area of ​​the white spots under the lamp is equal to the visual area. The fatigue symptoms are significantly improved, with occasional sighing, pale tongue, white fur, and a stringy and slippery pulse.

[0135] Case 8: Wei Jun, male, 37 years old. Date of visit: April 2024;

[0136] Chief complaint: In 2008, pale white patches were found on the skin of the neck without obvious cause, but no attention was paid to them at first. Later, the area of ​​the white patches expanded, so he went to Beijing Zhongke Vitiligo Hospital for treatment, and was diagnosed with "vitiligo". He was given epidermal melanin implantation treatment, and some white patches were restored. Now he comes to our hospital for further treatment. Since the onset of the disease, the patient has been sleeping well, eating well, and urinating and defecating normally. Recently, there has been no significant decrease in physical strength and weight. He is depressed, has chest tightness and shortness of breath, feels as if there is a foreign body in the throat, and sometimes feels bloated and uncomfortable in the chest and ribs. His tongue is pale red, his fur is thin and white, and his pulse is stringy.

[0137] Examination: Wood examination showed scattered flake-like white spots on the patient's neck with irregular shapes. The skin fluorescence reaction of the white spots under the Wood lamp was (+), with clear boundaries, and the area of ​​the white spots was equal to the visually observed area.

[0138] Initial diagnosis: Vitiligo

[0139] TCM diagnosis: Vitiligo-liver depression and qi stagnation

[0140] Treatment: Prescribe the Chinese medicine preparation in Example 3 for continuous use for 15 days;

[0141] The main complaint of the follow-up visit: No special discomfort after taking the medicine. The patient's neck white spots have formed small islands of melanin, and the area has slightly shrunk. The border is clear under the Wood lamp, and the area of ​​the white spots under the lamp is equal to the visual area. Chest tightness and shortness of breath have been significantly improved, there is no foreign body in the throat, and sighing is occasionally seen. The tongue is pale, the tongue coating is white, and the pulse is stringy and slippery.

Claims

1. A Chinese medicine composition for promoting recovery from vitiligo, characterized in that: The invention comprises the following components in parts by weight: 60-90 parts of Panax notoginseng, 60-80 parts of Psoralea corylifolia, 60-90 parts of Astragalus, 60-90 parts of Polygonatum sibiricum, 60-90 parts of Tribulus terrestris, 60-90 parts of Salvia miltiorrhiza, 100-140 parts of Millettia reticulata, 60-90 parts of Codonopsis pilosula, 60-90 parts of Atractylodes macrocephala, 60-90 parts of Bupleurum and 15-35 parts of Licorice.

2. The Chinese medicine composition for promoting recovery of vitiligo according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 70-80 parts of Panax notoginseng, 70-80 parts of Psoralea corylifolia, 70-80 parts of Astragalus membranaceus, 70-80 parts of Polygonatum sibiricum, 75-85 parts of Tribulus terrestris, 75-85 parts of Salvia miltiorrhiza, 120-130 parts of Millettia reticulata, 70-80 parts of Codonopsis pilosula, 75-85 parts of Atractylodes macrocephala, 75-85 parts of Bupleurum chinense and 20-30 parts of Licorice.

3. The Chinese medicine composition for promoting recovery from vitiligo according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 80 parts of Panax notoginseng, 70 parts of Psoralea corylifolia, 70 parts of Astragalus membranaceus, 80 parts of Polygonatum sibiricum, 85 parts of Tribulus terrestris, 75 parts of Salvia miltiorrhiza, 130 parts of Millettia spatholobi, 80 parts of Codonopsis pilosula, 85 parts of Atractylodes macrocephala, 75 parts of Bupleurum chinense and 20 parts of Licorice.

4. The Chinese medicine composition for promoting recovery from vitiligo according to claim 1 or 2, characterized in that: The invention comprises the following components in parts by weight: 70 parts of Panax notoginseng, 80 parts of Psoralea corylifolia, 80 parts of Astragalus membranaceus, 70 parts of Polygonatum sibiricum, 75 parts of Tribulus terrestris, 85 parts of Salvia miltiorrhiza, 120 parts of Millettia spatholobi, 70 parts of Codonopsis pilosula, 75 parts of Atractylodes macrocephala, 85 parts of Bupleurum chinense and 30 parts of Licorice.

5. The Chinese medicine composition for promoting recovery from vitiligo according to claim 1 or 2, characterized in that: The polygonatum sibiricum is steamed polygonatum sibiricum.

6. The Chinese medicine composition for promoting recovery from vitiligo according to claim 1 or 2, characterized in that: The tribulus terrestris is fried tribulus terrestris.

7. A Chinese medicine preparation for promoting recovery from vitiligo, characterized in that: A Chinese medicine composition comprising any one of claims 1-6.

8. The Chinese medicine preparation for promoting recovery of vitiligo according to claim 1, characterized in that: The Chinese medicine preparations include pills, tablets, granules, powders and mixtures.

9. The method for preparing the Chinese medicine preparation for promoting recovery of vitiligo according to claim 8, characterized in that: The following steps are involved: The above eleven herbs are decocted twice with water, the decoctions are combined, concentrated to 70-80% of the target volume, filtered, and then water is added to the target volume, filled, sterilized, and the product is obtained.

10. The method for preparing the Chinese medicine preparation for promoting recovery of vitiligo according to claim 9, characterized in that: Add 9-11 times the weight of the medicinal materials in water for the first time, and the decoction time is 1-3 hours. Add 7-9 times the amount of water for the second time, and the decoction time is 0.5-1.5 hours.

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