A pulverizing device for producing pharmaceutical intermediates

Abstract

The present invention relates to the technical field of crushing devices, and specifically discloses a crushing device for producing pharmaceutical intermediates, comprising a frame, a hopper, a screen, and a rotating drum, wherein the rotating drum comprises a scraper; two fixed disks are located at the left and right ends of the rotating drum in the length direction, and two push disks are located between the two fixed disks, each push disk is guided left and right and is movable and assembled on the rotating drum in a limited manner along the circumference of the push disk, and there is a bottom material gap between the outer edge of each push disk and the outer edge of the scraper, and a transmission shaft is distributed along the central axis of the rotating drum and passes through each push disk, and a first spiral groove that is spirally driven with each push disk is provided on the transmission shaft; a plurality of crushing rods are arranged on the opposite sides of the two fixed disks and on the left and right sides of each push disk; a cleaning brush is arranged on the outer peripheral side of each push disk, and the cleaning brush can extend into the material passing hole of the screen. The crushing device for producing pharmaceutical intermediates improves the overall crushing efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of crushing devices, and in particular to a crushing device for producing pharmaceutical intermediates. Background Art

[0002] Pharmaceutical intermediates refer to intermediate chemicals made in the process of chemical drug synthesis and are fine chemical products. They play an important role in the pharmaceutical industry chain, connecting the basic chemical raw material manufacturing industry and the chemical drug API and preparation manufacturing industry. The production process of pharmaceutical intermediates is a complex and strictly controlled process involving multiple key steps and quality control measures. When the synthesized pharmaceutical intermediates are in solid form, further crushing processing is usually required to ensure that the particle size distribution of the pharmaceutical intermediates meets specific quality standards. The swing granulator is a crushing equipment that can be used for crushing pharmaceutical intermediates. It uses the swinging action of the rotating drum to squeeze and rub the material on the screen, thereby crushing it through the screen.

[0003] The Chinese patent document with authorization announcement number CN212017968U discloses a swing granulator for pharmaceutical production. During the specific operation of the swing granulator for pharmaceutical production, the driving motor is connected to the external AC power, and the driving wheel is rotated by turning on the external control switch. The driving wheel drives the rotating rod to rotate through the conveyor belt. At this time, the two fixed plates on the U-shaped rod can rotate, so that the rubber strip on the fixed strip can rotate in the inner cavity of the arc-shaped net. When the inside is filled with materials, the rubber strip on the rotating fixed plate can squeeze and crush the materials. At the same time, the outer side of the driving wheel can drive the arc-shaped net to swing in the particle bin through the connecting rod. When swinging, the materials can be evenly distributed in the particle bin, which can ensure the uniform distribution of the materials, improve the efficiency of material crushing, and avoid the situation of material retention. Compared with the existing metal net outer surface crushing operation, this operation also has the function of protecting the arc-shaped net and increases the service life of the arc-shaped net.

[0004] However, during the operation of the above-mentioned swing granulator for pharmaceutical production in the prior art, when the material particles fed into the feeding sleeve are large, the large material particles are at the angle between the fixed plate and the arc-shaped net, and may be pushed by the outer peripheral wall of the fixed plate, and it is difficult to be squeezed and quickly crushed by the rubber strip. In addition, the large material particles may also block the feed holes of the arc-shaped net, affecting the crushing effect of other materials, and the crushing efficiency is low. Summary of the invention

[0005] The invention provides a pulverizing device for producing pharmaceutical intermediates, aiming to solve the problem of low pulverizing efficiency existing in a swing granulator for producing medicines in the related art.

[0006] The present invention provides a pulverizing device for producing pharmaceutical intermediates using the following technical solution:

[0007] A pulverizing device for producing pharmaceutical intermediates comprises a frame, a hopper arranged on the frame, a screen arranged in the hopper and extending left and right, and a rotating drum arranged above the screen and extending left and right, wherein the rotating drum comprises a scraper, the outer edge of which can contact the upper surface of the screen, and the hopper is also provided with a fixed disk, a push disk, a transmission shaft, a crushing rod, and a cleaning brush; two of the fixed disks are located at the left and right ends of the rotating drum in the length direction, and two of the push disks are located between the two fixed disks, each of the push disks is guided left and right and is movable and assembled on the rotating drum in a limited manner along the circumference of the push disk, and each of the fixed disks is provided with a fixed disk. There is a bottom material gap between the outer edge of the push plate and the outer edge of the scraper. The transmission shaft is distributed along the central axis of the rotating drum and passes through each push plate. A first spiral groove that is spirally transmitted to each push plate is opened on the transmission shaft, so that the two push plates can approach or move away from each other when the rotating drum rotates; a plurality of crushing rods are arranged on the opposite sides of the two fixed plates and on the left and right sides of each push plate, and the crushing rods opposite to each other can cooperate with each other when approaching each other to crush the material; a cleaning brush is arranged on the outer peripheral side of each push plate, and the cleaning brush can extend into the material passing hole of the screen.

[0008] With the above technical solution, a fixed plate, a push plate, a transmission shaft, a crushing rod and a cleaning brush are arranged in the hopper. The push plate is driven to rotate by the rotating drum, and the two push plates can be moved closer or farther away from each other by the transmission shaft as the rotating drum rotates. When the two push plates are moved closer or farther away from each other, the left and right sides of the push plates can push the top material above the bottom material layer to move, so that the top material is filled into the bottom material layer, and the outer peripheral side of the push plate can make the bottom material layer uniform and flat, which helps to make the material easier to pass through the screen for crushing. Then, the bottom material layer is crushed through the screen under the extrusion and shearing of the scraper, and the excess top material will gather between the two push plates and between the push plate and the fixed plate as the push plate moves, and under the mutual cooperation of the left and right relative crushing rods, the material is extruded, ground and mixed, and the material is more effectively crushed preliminarily. The material after the preliminarily crushing is easier to pass through the screen, reducing the risk of screen blockage. At the same time, the cleaning brush can also clean the screen to avoid screen blockage affecting the crushing effect, thereby improving the overall crushing efficiency.

[0009] Furthermore, the first spiral groove includes a forward thread segment and a reverse thread segment, wherein a forward slider movably assembled in the forward thread segment is fixed on one of the pusher discs, and a reverse slider movably assembled in the reverse thread segment is fixed on the other pusher disc.

[0010] Furthermore, the cleaning brush includes a brush base and bristles. The brush base is arc-shaped. A plurality of the brush bases are fixed on the push plate along the circumference of the push plate. The bristles are distributed on the outer peripheral side of each brush base and are made of elastic material.

[0011] Furthermore, the rotating drum includes two rotating rings opposite to each other on the left and right, and a plurality of scrapers fixed between the two rotating rings. The cross section of each scraper is triangular, and each scraper passes between two adjacent brush tables.

[0012] Furthermore, the breaker rod comprises a fixed sleeve, a telescopic rod, and a first spring. The fixed sleeve extends left and right, the telescopic rod is movably assembled in the fixed sleeve, and the first spring is connected between the telescopic rod and the fixed sleeve; each brush table protrudes a pushing plate to accommodate the breaker rod.

[0013] The above technical solution is adopted so that when the two pushing plates are close to each other, the sides of the brush tables opposite to each other can contact each other, and when the pushing plates are close to the fixed plate, the sides of the brush tables close to the fixed plate can contact each other with the fixed plate. In this way, the materials between the two pushing plates and between the pushing plates and the fixed plate can be effectively concentrated, so as to be fully crushed by the crushing rod.

[0014] Furthermore, the opposite sides of two adjacent brush tables form a material guiding slope for guiding the material to move outwards.

[0015] The above technical solution is adopted to help disperse the initially crushed materials into the bottom material layer.

[0016] Furthermore, a spiral spring is arranged between the transmission shaft and the fixed disk.

[0017] By adopting the above technical solution, the setting of the spiral spring enables the two push plates to move from the middle to the end of the first spiral groove, and the push plates can push the transmission shaft to rotate through the first spiral groove, so that the transmission shaft rotates synchronously with the push plates for a period of time to ensure the cleaning effect of the cleaning brush on the screens at the left and right ends.

[0018] Furthermore, one of the pushing plates includes a first plate body and a second plate body, the second plate body is rotatably installed in the first plate body, the first plate body faces the fixed plate and is provided with a plurality of crushing rods, the first plate body and the first spiral groove are spirally transmitted, the second plate body faces the other pushing plate and is provided with a plurality of crushing rods, a second spiral groove is also provided on the transmission shaft, the second plate body and the second spiral groove are spirally transmitted, so that when the two pushing plates rotate with the rotating drum, the rotation direction of the second plate body is opposite to the rotation direction of the first plate body.

[0019] Furthermore, the plurality of scrapers are divided into a first scraper and a second scraper, the cross section of the first scraper gradually increases from the middle to the left and right ends, and the cross section of the second scraper gradually increases from the left and right ends to the middle.

[0020] By adopting the above technical solution, when the rotary drum rotates, the first scraper can push the material in the middle to disperse to the left and right ends, and the second scraper can push the material at the left and right ends to disperse to the middle.

[0021] The beneficial effect of a pulverizing device for producing pharmaceutical intermediates provided by the present invention is that a fixed plate, a push plate, a transmission shaft, a crushing rod and a cleaning brush are arranged in the hopper. The push plate is driven to rotate by a rotating drum, and the two push plates can be moved closer to or farther away from each other by the transmission shaft when the rotating drum rotates. When the two push plates are moved closer to or farther away from each other, the left and right sides of the push plates can push the top material above the bottom material layer to move, so that the top material is filled into the bottom material layer, and the outer peripheral side of the push plate can make the bottom material layer uniform and flat, which helps to make the material easier to be crushed through the screen. Then, the bottom material layer is crushed through the screen under the extrusion and shearing of the scraper, and the excess top material will gather between the two push plates and between the push plate and the fixed plate as the push plate moves, and under the mutual cooperation of the left and right relative crushing rods, the material is extruded, ground and mixed, and the material is more effectively preliminarily crushed. The material after the preliminarily crushed is easier to pass through the screen, reducing the risk of screen blockage. At the same time, the cleaning brush can also clean the screen to avoid clogging of the screen and affect the crushing effect, thereby improving the overall crushing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a schematic diagram of the external structure of the pulverizing device for producing pharmaceutical intermediates of the present invention.

[0023] Figure 2 It is a cross-sectional view of a pulverizing device for producing a pharmaceutical intermediate according to the present invention.

[0024] Figure 3 It is a first structural schematic diagram of the hopper of the pulverizing device for producing pharmaceutical intermediates of the present invention.

[0025] Figure 4 It is a second structural schematic diagram of the hopper of the pulverizing device for producing pharmaceutical intermediates of the present invention.

[0026] Figure 5 It is a third structural schematic diagram of the hopper of the pulverizing device for producing pharmaceutical intermediates of the present invention.

[0027] Figure 6 The present invention is a schematic structural diagram of a rotating drum of a pulverizing device for producing a pharmaceutical intermediate.

[0028] Reference numerals:

[0029] 10. Frame; 110. Control cabinet; 120. Curvature adjustment mechanism; 20. Hopper; 210. Feed hopper body; 220. Crushing hopper body; 230. Discharge hopper body; 30. Rotating drum; 310. Rotating ring; 320. Scraper; 321. Clamping part; 322. Knife part; 40. Screen; 50. Fixed plate; 510. Volute spring; 60. Pushing plate; 610. First plate body; 620. Second plate body; 70. Transmission shaft; 710. First spiral groove; 711. Forward thread section; 712. Reverse thread section; 720. Second spiral groove; 80. Crushing rod; 810. Fixed sleeve; 820. Telescopic rod; 830. First spring; 90. Cleaning brush; 910. Brush table; 911. Material guide slope; 920. Bristles. DETAILED DESCRIPTION

[0030] Embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0031] like Figures 1 to 6 As shown, and refer to Figure 1 In the orientation shown in , the embodiment of the pulverizing device for producing pharmaceutical intermediates of the present invention comprises a frame 10, a control cabinet 110, a driving motor, a hopper 20, a screen 40, an arc adjustment mechanism 120, a rotating drum 30, a fixed plate 50, a push plate 60, a transmission shaft 70, a crushing rod 80, and a cleaning brush 90. Among them, the control cabinet 110 is fixedly mounted on the frame 10, and the driving motor is fixedly mounted in the control cabinet 110; four casters are installed at the lower end of the frame 10 to facilitate movement to adjust the position of the device; the hopper 20 is fixedly mounted on the left panel of the control cabinet 110; the screen 40, the rotating drum 30, the fixed plate 50, the push plate 60, the transmission shaft 70, the crushing rod 80, and the cleaning brush 90 are respectively installed in the hopper 20, and the arc adjustment mechanism 120 is arranged outside the hopper 20.

[0032] like Figures 1 to 3 As shown, the hopper 20 includes a feed hopper body 210, a crushing hopper body 220 and a discharge hopper body 230. The feed hopper body 210, the crushing hopper body 220 and the discharge hopper body 230 are arranged in sequence from top to bottom. The feed hopper body 210 is in a tapered shape with a gradually enlarged upper end, and is formed with a feed port for guiding the material into the crushing hopper body 220 for crushing. The screen 40, the rotating drum 30, the fixed plate 50, the push plate 60, the transmission shaft 70, the crushing rod 80, and the cleaning brush 90 are respectively installed in the crushing hopper body 220. The discharge hopper body 230 is in a tapered shape with a gradually reduced lower end, and is formed with a discharge port for guiding the material crushed in the crushing hopper body 220 to gather and discharge at the discharge port.

[0033] like Figure 2 As shown, the screen 40 is disposed in the crushing bucket 220 and extends in length to the left and right. The cross section of the screen 40 is U-shaped. The screen 40 has a material passing hole for passing the material to press the material into particles of a specific size. The mesh number of the screen 40 can be changed as needed to adjust the size of the particles. The curvature adjustment mechanism 120 is used to adjust the curvature of the screen 40 to meet different granulation requirements.

[0034] like Figures 2 to 6 As shown, the rotating drum 30 is arranged in the crushing bucket 220 and is located above the screen 40. The rotating drum 30 includes two rotating rings 310 opposite to each other on the left and right, and a plurality of scrapers 320 fixed between the two rotating rings 310. The length of each scraper 320 extends left and right, and the outer edge of the scraper 320 can contact the upper surface of the screen 40 to squeeze and shear the material. Each scraper 320 includes a clamping portion 321 and a knife portion 322 fixed to the outside of the clamping portion 321, the cross section of the clamping portion 321 is rectangular, and the cross section of the knife portion 322 is triangular. The output shaft of the driving motor is connected to the rotating ring 310 on the left to drive the rotating drum 30 to rotate around the central axis of the rotating drum 30.

[0035] The plurality of scrapers 320 are divided into a first scraper and a second scraper. The cross section of the first scraper gradually increases from the middle to the left and right ends, and the cross section of the second scraper gradually increases from the left and right ends to the middle. When the rotating drum 30 rotates, the first scraper can push the material in the middle to disperse to the left and right ends, and the second scraper can push the material at the left and right ends to disperse to the middle.

[0036] like Figure 3 As shown, two fixed disks 50 are fixed in the crushing bucket 220 and are respectively located at the left and right ends of the length direction of the rotating drum 30. Each fixed disk 50 is sleeved in the rotating ring 310, and the rotating ring 310 can rotate relative to the fixed disk 50.

[0037] like Figure 3 and Figure 5As shown, two pusher plates 60 are arranged in the crushing bucket 220 and located between the two fixed plates 50. The outer peripheral side of each pusher plate 60 is provided with a limiting groove corresponding to the scraper 320, and each limiting groove extends left and right. The clamping portion 321 of the scraper 320 is installed in the limiting groove, and the blade portion 322 of the scraper 320 extends out of the limiting groove, so that each pusher plate 60 is guided left and right and is moved and assembled on the rotating drum 30 along the circumferential direction of the pusher plate 60. That is, when the rotating drum 30 rotates, it can drive the pusher plate 60 to rotate synchronously, and the pusher plate 60 can move left and right on the rotating drum 30. There is a bottom material gap between the outer edge of each pusher plate 60 and the outer edge of the scraper 320, so that a thinner bottom material layer can be formed between the outer edge of the pusher plate 60 and the screen 40, which helps to make it easier for the material to pass through the screen 40, reduce the possibility of blockage, and improve the crushing efficiency.

[0038] like Figure 4 As shown, the push plate 60 on the right side includes a first plate body 610 and a second plate body 620. The second plate body 620 is located on the left side of the first plate body 610 and is rotatably mounted in the first plate body 610 to move left and right synchronously with the first plate body 610 and can rotate relative to the first plate body 610.

[0039] like Figures 2 to 4 As shown, the transmission shaft 70 is arranged in the crushing bucket 220 and distributed along the central axis of the rotating drum 30. The left and right ends of the transmission shaft 70 are rotatably mounted on the fixed disk 50 respectively, and each fixed disk 50 has a mounting cavity for accommodating a volute spring 510, and the volute spring 510 is connected between the transmission shaft 70 and the fixed disk 50. A first spiral groove 710 and a second spiral groove 720 are provided on the transmission shaft 70. The first spiral groove 710 includes a forward thread segment 711 located on the left side of the transmission shaft 70 and a reverse thread segment 712 located on the right side of the transmission shaft 70. The second spiral groove 720 is located on the right side of the transmission shaft 70, and has the same rotation direction as the forward thread segment 711.

[0040] The transmission shaft 70 passes through each pusher tray 60. A forward slider movably assembled in the forward thread segment 711 is fixed on the left pusher tray 60, and a reverse slider movably assembled in the reverse thread segment 712 is fixed on the first plate body 610 of the right pusher tray 60, so that the two pusher trays 60 can move closer to or farther away from each other as the rotating drum 30 rotates through spiral transmission. When the two pusher trays 60 move left and right, the left and right sides of the pusher trays 60 can push the top material above the bottom material layer to move, so that the top material is filled into the bottom material layer, and the outer peripheral side of the pusher tray 60 can make the bottom material layer uniform and flat, and then the bottom material layer is crushed through the screen 40 under the extrusion and shearing of the scraper 320; and the excess top material will gather between the two pusher trays 60 and between the pusher tray 60 and the fixed plate 50 as the pusher tray 60 moves, so as to facilitate the subsequent preliminary crushing of the gathered materials.

[0041] A second slider movably assembled in the second spiral groove 720 is fixed on the second disk body 620. Since the second spiral groove 720 has the same rotation direction as the forward thread segment 711, the second disk body 620 can be driven by the spiral so that when the second disk body 620 moves left and right with the first disk body 610, the rotation direction of the second disk body 620 is opposite to that of the first disk body 610.

[0042] like Figure 3 and Figure 4 As shown, a plurality of crushing rods 80 are provided on the opposite sides of the two fixed disks 50 and on the left and right sides of each push disk 60. Specifically, a plurality of crushing rods 80 are provided on the side of the first disk body 610 of the push disk 60 on the right side facing the fixed disk 50, and a plurality of crushing rods 80 are provided on the side of the second disk body 620 of the push disk 60 on the right side facing the other push disk 60. The crushing rods 80 opposite to each other are staggered and can cooperate with each other when approaching each other to extrude, grind, mix and crush the materials. The diameter and distribution density of the crushing rods 80 can be changed as needed to meet different crushing requirements. Each crushing rod 80 includes a fixed sleeve 810, a telescopic rod 820, and a first spring 830. The fixed sleeve 810 extends left and right, the telescopic rod 820 is movably assembled in the fixed sleeve 810, and the spring is connected between the telescopic rod 820 and the fixed sleeve 810. The provision of the elastic crushing rod 80 enables the crushing rod 80 to cooperate with the side of the pushing plate 60 or the fixed plate 50 to squeeze the material, providing a diversified crushing force and further improving the crushing effect.

[0043] It should be noted that when the two pusher plates 60 are close to each other so that the crushing rod 80 crushes the material between them, since the second plate body 620 rotates in the opposite direction to the first plate body 610, that is, the second plate body 620 rotates in the opposite direction to the pusher plate 60 on the left, the crushing rods 80 staggered on the pusher plate 60 on the left and the second plate body 620 produce a movement in the opposite direction of rotation, and the crushing rods 80 can apply force to the material from different angles, increasing the chance of the material being crushed, and can perform more effective preliminary crushing of the material. The material that has been initially crushed by the crushing rod 80 is dispersed to the left and right ends under the push of the first scraper, and is evenly spread into the bottom material layer, and then the bottom material layer is crushed through the screen 40 under the extrusion and shearing of the scraper 320. The material that has been initially crushed is easier to pass through the screen 40, reducing the risk of clogging of the screen 40 and improving the overall crushing efficiency.

[0044] In addition, the push plate 60 is close to the fixed plate 50, so that when the crushing rod 80 crushes the material between the two, the fixed plate 50 does not rotate, but the push plate 60 rotates, that is, the crushing rods 80 staggered on the push plate 60 and the fixed plate 50 rotate relative to each other, which also improves the crushing efficiency of the material. The material that has been initially crushed by the crushing rod 80 is dispersed to the middle under the push of the second scraper, and is evenly spread on the bottom material layer, and then the bottom material layer is crushed through the screen 40 under the extrusion and shearing of the scraper 320.

[0045] like Figure 2 , Figure 4 and Figure 5 As shown, a cleaning brush 90 is provided on the outer peripheral side of each push plate 60. The cleaning brush 90 includes a brush stand 910 and bristles 920. The brush stand 910 is arc-shaped, and a plurality of brush stands 910 are fixed on the push plate 60 along the circumference of the push plate 60. The bristles 920 are distributed on the outer peripheral side of each brush stand 910, and the bristles 920 are made of elastic material. The bristles 920 can extend into the feed hole of the screen 40 to clean the screen 40, so as to prevent the screen 40 from being blocked and affecting the crushing effect.

[0046] Each limiting groove is located between two adjacent brush stages 910, that is, each scraper 320 passes between two adjacent brush stages 910. In this way, when the push plate 60 drives the cleaning brush 90 to move left and right, the cleaning brush 90 moves left and right relative to the scraper 320, and the bristles 920 close to the scraper 320 can clean the material attached to the scraper 320.

[0047] Each brush table 910 protrudes from a pushing plate 60 to accommodate the crushing rod 80, so that when the two pushing plates 60 approach each other, the sides of the brush tables 910 opposite to each other can contact each other, and when the pushing plates 60 approach the fixed plate 50, the sides of the brush tables 910 close to the fixed plate 50 can contact each other with the fixed plate 50. In this way, the materials between the two pushing plates 60 and between the pushing plates 60 and the fixed plate 50 can be effectively concentrated, so as to be fully crushed by the crushing rod 80.

[0048] The opposite sides of two adjacent brush tables 910 form a material guiding slope 911 for guiding the material to move outward, which is beneficial to help the initially crushed material to be dispersed into the bottom material layer.

[0049] It should be noted that the setting of the spiral spring 510 enables the push plate 60 to push the transmission shaft 70 to rotate through the first spiral groove 710 after the two push plates 60 move from the middle to the end of the first spiral groove 710, so that the transmission shaft 70 rotates synchronously with the push plate 60 for a period of time to ensure the cleaning effect of the cleaning brush 90 on the left and right ends of the screen 40.

[0050] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0051] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0052] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A pulverizing device for producing pharmaceutical intermediates, comprising a frame, a hopper arranged on the frame, a screen arranged in the hopper and extending in length to the left and right, and a rotating drum arranged above the screen and extending in length to the left and right, characterized in that: The rotating drum includes a scraper, the outer edge of which can contact the upper surface of the screen, and the hopper is also provided with a fixed plate, a push plate, a transmission shaft, a breaking rod, and a cleaning brush; The two fixed plates are located at the left and right ends of the rotating drum in the length direction, and the two push plates are located between the two fixed plates. Each of the push plates is guided left and right and is movable and limitedly assembled on the rotating drum along the circumference of the push plate. There is a bottom material gap between the outer edge of each push plate and the outer edge of the scraper. The transmission shaft is distributed along the central axis of the rotating drum and passes through each push plate. A first spiral groove that is spirally transmitted with each push plate is opened on the transmission shaft, so that the two push plates can approach or move away from each other when the rotating drum rotates; A plurality of crushing rods are arranged on the opposite sides of the two fixed plates and on the left and right sides of each pushing plate. When the crushing rods on the left and right sides are close to each other, they can cooperate with each other to crush the materials. A cleaning brush is arranged on the outer circumference of each pusher plate, and the cleaning brush can extend into the feeding hole of the screen; the first spiral groove includes a forward thread segment and a reverse thread segment, one of the pushers is fixed with a forward slider movably assembled in the forward thread segment, and the other pusher plate is fixed with a reverse slider movably assembled in the reverse thread segment; The cleaning brush comprises a brush stand and bristles, the brush stand is arc-shaped, a plurality of the brush stands are fixed on the pushing plate along the circumference of the pushing plate, the bristles are distributed on the outer circumference of each brush stand, and the bristles are made of elastic material; A volute spring is arranged between the transmission shaft and the fixed disk; One of the pushing discs includes a first disc body and a second disc body, the second disc body is rotatably installed in the first disc body, the first disc body faces the fixed disc and is provided with a plurality of crushing rods, the first disc body and the first spiral groove are spirally driven, the second disc body faces the other pushing disc and is provided with a plurality of crushing rods, a second spiral groove is also provided on the transmission shaft, the second disc body and the second spiral groove are spirally driven, so that when the two pushing discs rotate with the rotating drum, the rotation direction of the second disc body is opposite to that of the first disc body; the second spiral groove is located on the right side of the transmission shaft and has the same rotation direction as the forward thread segment; The plurality of scrapers are divided into a first scraper and a second scraper. The cross section of the first scraper gradually increases from the middle to the left and right ends, and the cross section of the second scraper gradually increases from the left and right ends to the middle.

2. A pulverizing device for producing pharmaceutical intermediates according to claim 1, characterized in that: The rotating drum comprises two rotating rings opposite to each other, and a plurality of scrapers fixed between the two rotating rings. The cross section of each scraper is triangular, and each scraper passes between two adjacent brush tables.

3. A pulverizing device for producing pharmaceutical intermediates according to claim 1, characterized in that: The breaker rod comprises a fixed sleeve, a telescopic rod, and a first spring. The fixed sleeve extends left and right, the telescopic rod is movably assembled in the fixed sleeve, and the first spring is connected between the telescopic rod and the fixed sleeve. Each brush table protrudes a pushing plate to accommodate the breaker rod.

4. A pulverizing device for producing pharmaceutical intermediates according to claim 2, characterized in that: The opposite sides of two adjacent brush tables form a material guiding slope for guiding the material to move outwards.

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