Pathogenic microorganism resistance detection device

Abstract

The present invention is applicable to the field of pathogenic microorganism research technology and provides a pathogenic microorganism resistance detection device, comprising: a detection box for pathogenic microorganism resistance detection, wherein two vertical partitions are fixedly installed in the detection box, and a horizontal partition is fixedly installed between the two vertical partitions, and the horizontal partition divides the space between the two vertical partitions into two upper and lower detection chambers, namely a hot detection chamber and a cold detection chamber; two first placement seats disposed within the two detection chambers, each of the first placement seats being provided with a plurality of annular placement slots for accommodating multiple culture dishes for culturing pathogenic microorganisms; wherein the detection box is provided with a drug injection mechanism for injecting a drug for detecting pathogenic microorganism resistance into the culture dishes. The pathogenic microorganism resistance detection device provided by this solution can simultaneously perform resistance detection at different temperatures and drug concentrations, greatly shortens the time required for pathogenic microorganism resistance detection, and improves detection efficiency.

Description

Technical Field

[0001] The present invention belongs to the technical field of pathogenic microorganism research, and in particular relates to a pathogenic microorganism resistance detection device. Background Art

[0002] Pathogens are microorganisms that can invade the human body and cause infection or even infectious diseases. Among pathogens, bacteria and viruses are the most harmful. Pathogens include prions, fungi, bacteria, spirochetes, mycoplasmas, rickettsiae, chlamydiae, and viruses. Studying pathogens and their resistance is crucial for preventing and controlling disease, guiding clinical treatment, and optimizing the use of antimicrobial drugs. Understanding the resistance mechanisms of pathogens can guide rational clinical drug use, avoid the misuse of antimicrobial drugs, and reduce the development of drug resistance. Studying the resistance of pathogens can also help explore new antimicrobial drug targets and provide insights and methods for the development of new antimicrobial drugs.

[0003] Currently, existing pathogen resistance detection devices typically place the test sample in a culture dish, add the drug, and then place the dish in a testing chamber. Resistance is determined by observing the growth of the microorganisms in the dish. However, existing pathogen resistance detection devices struggle to simultaneously detect resistance in pathogens at different temperatures and drug concentrations. Multiple resistance tests are required to fully understand the effects of temperature and drug concentration on pathogens, significantly increasing resistance testing time and reducing detection efficiency. Summary of the Invention

[0004] In order to solve the technical problem that existing devices are difficult to simultaneously evaluate the drug resistance of pathogenic microorganisms at different temperatures and drug concentrations, and often require multiple repeated tests, which is not only time-consuming but also reduces detection efficiency, the present invention provides a pathogen resistance detection device.

[0005] The present invention is implemented as follows: a pathogen resistance detection device includes: a detection box for pathogen resistance detection, two vertical partitions are fixedly installed in the detection box, and a horizontal partition is fixedly installed between the two vertical partitions, and the horizontal partition divides the space between the two vertical partitions into two upper and lower detection chambers, namely a hot detection chamber and a cold detection chamber; two first placement seats are arranged in the two detection chambers, and the first placement seats are provided with multiple annular placement grooves for placing multiple culture dishes for culturing pathogenic microorganisms; wherein, the detection box is provided with a drug injection mechanism for injecting a drug for detecting the resistance of pathogenic microorganisms into the culture dish; and a first transmission mechanism is provided in the detection box for causing the two first placement seats to rotate simultaneously to switch the culture dishes.

[0006] Preferably, two mounting plates are fixedly installed between the two vertical partitions for supporting the two first placement seats, and the first transmission mechanism includes: two first central shafts respectively fixedly installed on the bottom of the two first placement seats, and the two first central shafts are respectively rotatably connected to the two mounting plates; a first rotating rod rotatably installed on one side of one of the vertical partitions; four first synchronous pulleys respectively fixedly mounted on the bottom ends of the two first central shafts and the first rotating rod, and a first synchronous belt is respectively mounted between the two first synchronous pulleys at the bottom ends of the two first central shafts and the two first synchronous pulleys on the first rotating rod; wherein, the first transmission mechanism is also equipped with a power drive mechanism for driving the first rotating rod in the first transmission mechanism to rotate so as to realize the rotation of the first placement seat.

[0007] Preferably, a second placement seat is provided above the top of the detection box, and a plurality of annular placement slots are provided on the second placement seat for placing a plurality of medicine bottles containing medicines of different concentrations to provide medicines of different concentrations for pathogen resistance testing. A second transmission mechanism is installed in the detection box to drive the second placement seat to rotate so as to switch different medicine bottles.

[0008] Preferably, the second transmission mechanism includes: a second central shaft fixedly mounted on the bottom of the second placement seat, the second central shaft being rotatably connected to the top of the detection box; two second synchronous pulleys respectively fixedly sleeved on the bottom end of the second central shaft and the first rotating rod, a second synchronous belt being sleeved between the two second synchronous pulleys.

[0009] Preferably, the top of the detection box is hinged with a protective box with an open bottom, and the protective box covers the second placement seat and the medicine bottles thereon inside the protective box. A U-shaped handle is installed on one side of the protective box for opening the protective box.

[0010] Preferably, the injection mechanism includes: a micro liquid pump fixedly mounted on the inner wall of one side of the detection box and located outside the detection room, the liquid inlet end of the micro liquid pump being connected to a liquid inlet hose; a liquid inlet elbow fixedly connected to the other end of the liquid inlet hose, one end of the liquid inlet elbow being connected to a straw for drawing liquid medicine from a medicine bottle; an electric telescopic rod fixedly mounted on the protective box, the output dry bottom end of the electric telescopic rod fixedly connected to the liquid inlet elbow, for moving vertically downward to extend the bottom end of the straw into the medicine bottle; a three-way pipe fixedly connected to the liquid outlet end of the micro liquid pump, the other two ports of the three-way pipe being connected to a liquid outlet hose; two liquid outlet elbows both fixedly mounted on a vertical partition, one end of the two liquid outlet elbows being respectively connected to one end of two liquid outlet hoses; two nozzles respectively fixedly mounted on the bottom ends of the two liquid outlet elbows, both nozzles being horizontally arranged, and a plurality of liquid spray holes being opened at the bottom, and the nozzles being located directly above the corresponding culture dishes.

[0011] Preferably, a plurality of placement slots on the first placement seat are each provided with a placement plate, a placement slot for placing a culture dish is provided on the top of the placement plate, and a third transmission mechanism is provided in the detection box for driving the corresponding placement plates on the two first placement seats to rotate synchronously, so that the agent can be evenly sprayed into the entire culture dish, thereby improving the resistance detection effect of pathogenic microorganisms, and the third transmission mechanism includes: a plurality of third central shafts respectively fixedly mounted on the bottom of the plurality of placement plates, and the plurality of third central shafts are respectively rotatably connected to the two first placement seats; a plurality of first straight shafts respectively fixedly sleeved on the bottom ends of the plurality of third central shafts Gears; respectively rotate the two fourth central shafts mounted on the two mounting plates, the top ends of the two fourth central shafts are fixedly sleeved with a second spur gear, and the two second spur gears are respectively engaged with the two first spur gears; rotate the second rotating rod mounted on the side of the vertical partition away from the first rotating rod, and the second rotating rod is fixedly sleeved with two third synchronous pulleys; respectively fixedly sleeved with two fourth synchronous pulleys on the bottom ends of the two fourth central shafts, and the two fourth synchronous pulleys are respectively sleeved with third synchronous belts on the two third synchronous pulleys; wherein, the power drive mechanism is also used to drive the second rotating rod to rotate so as to rotate the corresponding two storage plates.

[0012] It should be noted that the bearings used for the rotation of the first central axis, the second central axis and the fourth central axis are damping bearings, that is, the first placement seat, the second placement seat and the storage plate will not rotate at will without the action of external force.

[0013] Preferably, the power drive mechanism includes: a dual-axis motor fixedly mounted on the inner wall of the bottom of the detection box; two connecting shafts respectively fixedly mounted on the two output shafts of the dual-axis motor, and a connecting block is fixedly mounted on one end of the two connecting shafts away from each other; two rotating shafts respectively mounted on the two vertical partitions, the bottom end of the first rotating rod and one end of the corresponding rotating shaft are fixedly sleeved with a first bevel gear, and the two first bevel gears are meshed with each other; two second bevel gears respectively fixedly sleeved on the second rotating rod and one end of the other rotating shaft, and the two second bevel gears are meshed with each other; wherein a ratchet mechanism is connected between the rotating shaft and the connecting block, and the two ratchet mechanisms are symmetrically arranged, for making the two rotating shafts only able to rotate in one direction and reverse direction, that is, when the dual-axis motor rotates forward, the connecting shaft can drive one rotating shaft to rotate, while the other rotating shaft does not rotate, conversely, that is, when the dual-axis motor reverses, one rotating shaft does not rotate, and the connecting shaft can drive the other rotating shaft to rotate in the reverse direction.

[0014] Preferably, a semiconductor refrigeration plate is embedded in the transverse partition, with the heat-generating side of the semiconductor refrigeration plate facing upward and the cooling side facing downward. Fans are installed on both sides of the semiconductor refrigeration plate, and a plurality of heat dissipation holes are provided on the upper mounting plate for allowing heat to pass through the heat dissipation holes to heat the thermal detection chamber.

[0015] Preferably, two temperature sensors are installed on one of the vertical partitions, and probes of the two temperature sensors extend into the two detection chambers respectively.

[0016] Preferably, a plurality of germicidal lamps are fixedly installed on the side of the two vertical partitions close to each other. The germicidal lamps are located in the two detection chambers and are used to sterilize and disinfect the two detection chambers before performing resistance testing on pathogenic microorganisms.

[0017] Preferably, a control panel is provided in the detection box for setting parameters and controlling the operation of the equipment, and two front door panels are provided on the front side of the detection box, corresponding to two detection chambers for taking and placing culture dishes, and visual glass observation windows are provided on the two front door panels. The rear side of the detection box is set to be open and is installed with a rear inspection panel.

[0018] Compared with related technologies, the pathogenic microorganism resistance detection device provided by the present invention has the following beneficial effects:

[0019] The pathogenic microorganism resistance detection device of the present invention exhibits significant advantages in that it can simultaneously perform resistance detection at different temperatures and drug concentrations, a function that is crucial for the screening of new drugs and the re-evaluation of existing drugs.

[0020] The automated testing process of the present invention significantly reduces human interference and ensures high repeatability and accuracy of experimental results. This feature not only improves detection efficiency but also ensures the reliability and consistency of experimental data, providing a solid foundation for scientific research and clinical applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 A schematic diagram of the three-dimensional structure of a pathogenic microorganism resistance detection device provided by the present invention;

[0022] Figure 2 This is a schematic front view of the structure of a pathogenic microorganism resistance detection device provided by the present invention;

[0023] Figure 3 A schematic diagram of a front cross-sectional structure of a pathogenic microorganism resistance detection device provided by the present invention;

[0024] Figure 4 for Figure 3 Schematic diagram of the enlarged structure of part A shown in FIG;

[0025] Figure 5 for Figure 3 Schematic diagram of the enlarged structure of part B shown in FIG;

[0026] Figure 6 for Figure 3 Schematic diagram of the enlarged structure of part C shown in;

[0027] Figure 7 for Figure 3 Schematic diagram of the enlarged structure of part D shown in FIG;

[0028] Figure 8 for Figure 3 Schematic diagram of the enlarged structure of part E shown in FIG;

[0029] Figure 9 for Figure 3 Schematic diagram of the enlarged structure of part F shown in FIG;

[0030] Figure 10 for Figure 3 Schematic diagram of the enlarged structure of part G shown in FIG;

[0031] Figure 11 for Figure 3 Schematic diagram of the enlarged structure of part H shown in FIG;

[0032] Figure 12 for Figure 3 Schematic diagram of the enlarged structure of part I shown in FIG;

[0033] Figure 13 Schematic diagram of the top view of the assembly of the first placement seat and the storage plate in the present invention;

[0034] Figure 14 Schematic diagram of the top view of the mounting plate located in the hot chamber of the present invention;

[0035] Figure 15 Schematic diagram of the side structure of the connecting block in the present invention;

[0036] Figure 16 It is a rear view structural schematic diagram of the present invention;

[0037] Figure 17 It is a schematic side cross-sectional structural diagram of the interior of the ratchet mechanism in the present invention.

[0038] Figure numerals: 1, detection box; 2, vertical partition; 3, horizontal partition; 4, first placement seat; 5, mounting plate; 6, first central axis; 7, first rotating rod; 8, first synchronous pulley; 9, first synchronous belt; 10, second placement seat; 11, medicine bottle; 12, second central axis; 13, second synchronous pulley; 14, second synchronous belt; 15, protective box; 16, micro liquid pump; 17, liquid inlet hose; 18, liquid inlet elbow; 19, straw; 20, electric telescopic rod; 21, three-way pipe; 22, liquid outlet hose; 23, liquid outlet elbow; 24, nozzle; 25, storage plate; 26, culture dish; 27, third central axis; 28, first A straight gear; 29, fourth center axis; 30, second spur gear; 31, second rotating rod; 32, third synchronous pulley; 33, fourth synchronous pulley; 34, third synchronous belt; 35, dual-axis motor; 36, connecting shaft; 37, connecting block; 38, rotating shaft; 39, first bevel gear; 40, second bevel gear; 41, ratchet mechanism; 42, semiconductor cooling plate; 43, fan; 44, temperature sensor; 45, germicidal lamp; 101, control panel; 102, front door panel; 103, rear inspection panel; 201, U-shaped handle; 411, ratchet; 412, driven wheel; 413, pawl; 501, heat dissipation hole. DETAILED DESCRIPTION

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of the application are only for the purpose of describing specific embodiments and are not intended to limit this application. The terms "including" and "having" and any variations thereof in the specification of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification of this application and the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.

[0040] References herein to "embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0041] The embodiment of the present invention provides a pathogenic microorganism resistance detection device, such as Figure 1-17As shown, the pathogen resistance detection device includes: a detection box 1 for pathogen resistance detection, two vertical partitions 2 are fixedly installed in the detection box 1, and a horizontal partition 3 is fixedly installed between the two vertical partitions 2, and the horizontal partition 3 divides the space between the two vertical partitions 2 into two upper and lower detection chambers, namely a hot detection chamber and a cold detection chamber; two first placement seats 4 are arranged in the two detection chambers, and the first placement seats 4 are provided with a plurality of annular placement grooves for placing a plurality of culture dishes 26 for culturing pathogenic microorganisms; wherein, the detection box 1 is provided with a drug injection mechanism for injecting a drug for detecting the resistance of pathogenic microorganisms into the culture dish 26; and a first transmission mechanism is provided in the detection box 1 for rotating the two first placement seats 4 at the same time to switch the culture dish 26.

[0042] In this embodiment, the pathogen resistance detection device significantly improves detection efficiency through ingenious design. Two vertical partitions 2 fixedly mounted within the detection chamber 1 work together with a horizontal partition 3 to precisely divide the chamber space into a hot detection chamber and a cold detection chamber, enabling pathogen resistance testing under different temperature conditions. The annular placement slots on the first placement seat 4 can simultaneously accommodate multiple culture dishes 26. Combined with the first transmission mechanism, this enables automatic switching of culture dishes, eliminating the need for frequent manual operation and significantly improving the automation level and work efficiency of the test. The provision of a drug injection mechanism enables the precise injection of the drug into each culture dish 26, ensuring consistent testing conditions and reducing human error. The use of the first transmission mechanism allows the two first placement seats 4 to rotate synchronously, saving operating time and ensuring parallelism and comparability of the tests. By simultaneously testing the resistance of pathogens under different temperature conditions and drug concentrations, the device significantly shortens the detection cycle and improves detection efficiency.

[0043] In a further preferred embodiment of the present invention, two mounting plates 5 are fixedly installed between the two vertical partitions 2 for supporting the two first placement seats 4, and the first transmission mechanism includes: two first central shafts 6 respectively fixedly installed on the bottom of the two first placement seats 4, and the two first central shafts 6 are respectively rotatably connected to the two mounting plates 5; a first rotating rod 7 rotatably installed on one side of one of the vertical partitions 2; four first synchronous pulleys 8 respectively fixedly mounted on the bottom ends of the two first central shafts 6 and the first rotating rod 7, and a first synchronous belt 9 is respectively mounted between the two first synchronous pulleys 8 at the bottom ends of the two first central shafts 6 and the two first synchronous pulleys 8 on the first rotating rod 7; wherein, the first transmission mechanism is also equipped with a power drive mechanism for driving the first rotating rod 7 in the first transmission mechanism to rotate so as to realize the rotation of the first placement seat 4.

[0044] In this embodiment, the two mounting plates 5 added between the two vertical partitions 2 not only firmly support the two first placement seats 4 but also cleverly integrate key components of the first transmission mechanism. The rotatable connection between the first central axis 6 and the mounting plates 5 ensures flexible rotation of the first placement seats 4. The rotatable mounting of the first rotating rod 7, along with the four first synchronous pulleys 8 and first synchronous belt 9, forms an efficient and precise transmission system, enabling stable and synchronized rotation of the first placement seats 4.

[0045] The introduction of a power drive mechanism provides a source of power for the rotation of the first rotating rod 7. This, in turn, drives the precise rotation of the two first placement seats 4 through the linkage of the first synchronous pulley 8 and the first synchronous belt 9, ensuring the automatic switching of the culture dishes 26. This design not only reduces the complexity of manual operation but also significantly improves the level of automation in testing, making the pathogen resistance testing process more efficient and accurate. By optimizing the first transmission mechanism, this invention further improves detection efficiency while ensuring the reliability of test results, providing strong technical support for pathogen resistance research.

[0046] In a further preferred embodiment of the present invention, a second placement seat 10 is provided above the top of the detection box 1. The second placement seat 10 is provided with a plurality of annular placement slots for placing a plurality of medicine bottles 11 containing medicines of different concentrations to provide medicines of different concentrations for pathogen resistance testing. A second transmission mechanism is installed in the detection box 1 to drive the second placement seat 10 to rotate to switch different medicine bottles 11.

[0047] In this embodiment, a second placement seat 10 is cleverly positioned on the top of the test box 1. The multiple, annularly arranged storage slots are not only aesthetically pleasing but, more importantly, can efficiently accommodate multiple medicine bottles 11 containing varying concentrations of medication, providing a diverse selection of medications for pathogen resistance testing. The assembly of a second transmission mechanism enables automatic rotation of the second placement seat 10, enabling rapid and precise switching to the desired medicine bottle 11, ensuring pathogen resistance testing at varying concentrations. This design not only greatly enriches testing conditions, enabling the assessment of pathogen tolerance to varying concentrations within the same test, but also reduces human error through automated operation, improving test accuracy and repeatability. Through the efficient operation of the second transmission mechanism, the present invention further optimizes the testing process, shortens the testing cycle, and provides a more precise and efficient technical approach for in-depth research on pathogen resistance and drug development.

[0048] In a further preferred embodiment of the present invention, the second transmission mechanism includes: a second central shaft 12 fixedly mounted on the bottom of the second placement seat 10, the second central shaft 12 being rotatably connected to the top of the detection box 1; two second synchronous pulleys 13 respectively fixedly sleeved on the bottom end of the second central shaft 12 and the first rotating rod 7, and a second synchronous belt 14 being sleeved between the two second synchronous pulleys 13.

[0049] In this embodiment, the sophisticated design of the second transmission mechanism further enhances the automation and efficiency of the inspection device. A second central shaft 12, fixed to the bottom of the second placement seat 10 and pivotally connected to the top of the inspection box 1, ensures stable rotation of the second placement seat 10. Two second synchronous pulleys 13, respectively fixed to the bottom end of the second central shaft 12 and the first rotating rod 7, synchronize the movement of the second placement seat 10 and the first rotating rod 7 through the linkage of a second synchronous belt 14.

[0050] This design not only simplifies the operational process by enabling simultaneous adjustment of both the first and second placement seats 4, 10 with a single actuation, ensuring precise switching of testing conditions, but also significantly enhances testing flexibility and efficiency. The rapid switching of different concentration vials 11, combined with the automatic rotation of the culture dish 26, enables comprehensive assessment of pathogen resistance under a variety of conditions within a single test. This provides strong technical support for in-depth research into pathogen resistance mechanisms and antimicrobial drug development, significantly shortens testing cycles, and improves the accuracy and reliability of test results.

[0051] In another embodiment of the present invention, a protective box 15 with an open bottom is hinged on the top of the detection box 1. The protective box 15 covers the second placement seat 10 and the medicine bottle 11 thereon in the protective box 15. A U-shaped handle 201 is installed on one side of the protective box 15 for opening the protective box 15.

[0052] In this embodiment, a protective box 15 with an open bottom is cleverly hinged to the top of the testing box 1. This design encloses the second placement seat 10 and the medicine bottles 11 on it, creating a relatively closed yet user-friendly environment. A U-shaped handle 201 mounted on one side of the protective box 15 facilitates opening the protective box 15, allowing testers to quickly place or replace medicine bottles 11. This design not only effectively protects the medicine bottles 11 from external contamination, ensuring pure testing conditions, but also helps maintain the stability of the testing environment, preventing external interference from affecting test results.

[0053] In another embodiment of the present invention, the injection mechanism includes: a micro liquid pump 16 fixedly mounted on the inner wall of one side of the detection box 1 and located outside the detection room, the liquid inlet end of the micro liquid pump 16 is connected to a liquid inlet hose 17; a liquid inlet elbow 18 fixedly connected to the other end of the liquid inlet hose 17, one end of the liquid inlet elbow 18 is connected to a straw 19 for sucking liquid medicine from the medicine bottle 11; an electric telescopic rod 20 fixedly mounted on the protective box 15, the output dry bottom end of the electric telescopic rod 20 is fixedly connected to the liquid inlet elbow 18, and is used to move vertically downward. , insert the bottom end of the pipette 19 into the medicine bottle 11; a three-way pipe 21 is fixedly connected to the liquid outlet end of the micro liquid pump 16, and the other two ports of the three-way pipe 21 are connected to a liquid outlet hose 22; two liquid outlet elbows 23 are fixedly installed on a vertical partition 2, and one end of the two liquid outlet elbows 23 is respectively connected to one end of the two liquid outlet hoses 22; two nozzles 24 are respectively fixedly installed at the bottom ends of the two liquid outlet elbows 23, and the two nozzles 24 are both horizontally arranged and have multiple liquid spray holes at the bottom. The nozzles 24 are located directly above the corresponding culture dishes 26.

[0054] In this embodiment, the design of the injection mechanism realizes the precise and automatic delivery of the medicine. The micro liquid pump 16 is the core component. Through the connection of the liquid inlet hose 17 and the liquid inlet elbow 18, it cooperates with the suction pipe 19 to accurately extract the medicine in the medicine bottle 11. The setting of the electric telescopic rod 20 ensures that the suction pipe 19 can accurately extend into the medicine bottle 11 to achieve the absorption of the medicine. The configuration of the three-way pipe 21 and the liquid outlet hose 22, supplemented by the liquid outlet elbow 23 and the nozzle 24, forms a complete medicine delivery system. The nozzle 24 is horizontally arranged just above the culture dish 26, and the multiple liquid spray holes opened at its bottom ensure that the medicine can be sprinkled on the culture dish 26, thereby ensuring the consistency of the detection conditions. This series of designs not only realizes the automatic and precise delivery of medicines, but also greatly improves the accuracy and reproducibility of the detection, provides strong technical support for the resistance detection of pathogenic microorganisms, and ensures the reliability of the detection results and the improvement of detection efficiency.

[0055] In a further preferred embodiment of the present invention, a plurality of placement slots on each of the first placement seats 4 are provided with placement plates 25, and a placement slot for placing a culture dish 26 is provided on the top of each of the placement plates 25. A third transmission mechanism is provided in the detection box 1 for driving the corresponding placement plates 25 on the two first placement seats 4 to rotate synchronously so that the agent can be evenly sprayed into the entire culture dish 26 to improve the resistance detection effect of pathogenic microorganisms. The third transmission mechanism includes: a plurality of third central shafts 27 respectively fixedly mounted on the bottom of the plurality of placement plates 25, and the plurality of third central shafts 27 are respectively rotatably connected to the two first placement seats 4; a plurality of first straight gears respectively fixedly sleeved on the bottom ends of the plurality of third central shafts 27. 28; the two fourth central shafts 29 respectively mounted on the two mounting plates 5 are rotated, the top ends of the two fourth central shafts 29 are fixedly sleeved with a second spur gear 30, and the two second spur gears 30 are respectively engaged with the two first spur gears 28; the second rotating rod 31 mounted on the side of the vertical partition 2 away from the first rotating rod 7 is rotated, and two third synchronous pulleys 32 are fixedly sleeved on the second rotating rod 31; the two fourth synchronous pulleys 33 respectively fixedly sleeved on the bottom ends of the two fourth central shafts 29, and the two fourth synchronous pulleys 33 are respectively sleeved with third synchronous belts 34 on the two third synchronous pulleys 32; wherein, the power drive mechanism is also used to drive the second rotating rod 31 to rotate, so as to rotate the corresponding two storage plates 25.

[0056] In this embodiment, multiple storage plates 25 on the first storage seat 4, through slots defined at their tops, precisely position culture dishes 26. The introduction of a third transmission mechanism enables synchronized rotation of the storage plates 25, ensuring that the reagent evenly covers the entire culture dish 26, significantly improving the accuracy and reliability of pathogen resistance testing. Multiple third central shafts 27, rotatably connected to the first storage seat 4, cooperate with the first spur gear 28 to ensure stable rotation of the storage plates 25.

[0057] The meshing of the second spur gears 30 and first spur gears 28 on the two fourth central shafts 29 ensures efficient power transmission, while the combination of the second rotating rod 31, third synchronous pulley 32, fourth synchronous pulley 33, and third synchronous belt 34 further enhances transmission precision and stability. The reuse of the power drive mechanism demonstrates efficient resource integration, enabling the rotation of the second rotating rod 31 and, in turn, ensuring precise rotation of the storage plate 25, ensuring uniform spraying of the medication.

[0058] It should be noted that the bearings used to rotate the first central axis 6, the second central axis 12, and the fourth central axis 29 are damping bearings. This means that the first and second placement seats 4, 10, and the storage plate 25 will not rotate freely without external forces. The use of damping bearings effectively prevents the first and second placement seats 4, 10, and the storage plate 25 from rotating freely without external forces, ensuring stable testing conditions.

[0059] In a further preferred embodiment of the present invention, the power drive mechanism includes: a dual-axis motor 35 fixedly mounted on the inner wall of the bottom of the detection box 1; two connecting shafts 36 respectively fixedly mounted on the two output shafts of the dual-axis motor 35, and a connecting block 37 is fixedly mounted on one end of the two connecting shafts 36 away from each other; two rotating shafts 38 respectively rotatably mounted on the two vertical partitions 2, the bottom end of the first rotating rod 7 and one end of the corresponding rotating shaft 38 are fixedly sleeved with a first bevel gear 39, and the two first bevel gears 39 are meshed; respectively fixedly sleeved on the first The two second bevel gears 40 on the second rotating rod 31 and one end of the other rotating shaft 38 are meshed with each other; wherein a ratchet mechanism 41 is connected between the rotating shaft 38 and the connecting block 37, and the two ratchet mechanisms 41 are symmetrically arranged to enable the two rotating shafts 38 to rotate only in one direction and reversely, that is, when the dual-axis motor 35 rotates forward, the connecting shaft 36 can drive one rotating shaft 38 to rotate, while the other rotating shaft does not rotate; conversely, when the dual-axis motor 35 rotates reversely, one rotating shaft does not rotate, and the connecting shaft 36 can drive the other rotating shaft 38 to rotate reversely.

[0060] In this embodiment, the ingenious design of the power drive mechanism provides a stable source of power for core operations. The dual-axis motor 35, serving as the power source, effectively transmits power through the connecting shaft 36 and connecting block 37 on its output shaft. The precise meshing of the first bevel gear 39 and the second bevel gear 40 ensures precise distribution and conversion of power. The innovative use of two ratchet mechanisms 41 enables the two rotating shafts 38 to rotate in both directional and opposite directions. This, combined with the forward and reverse rotation of the dual-axis motor 35, enables precise control of the first rotating rod 7 and the second rotating rod 31.

[0061] This design not only achieves efficient power transmission and conversion, but also, through clever structural arrangement, ensures the independent and coordinated operation of the first and second placement seats 4, 10, and the precise rotation of the storage plate 25, creating conditions for uniform spraying of the agent. By optimizing the power drive mechanism, the present invention achieves a highly automated and intelligent detection device, significantly improving detection accuracy and efficiency, and providing strong technical support for in-depth research on pathogen resistance testing. The innovative and practical nature of this design not only demonstrates precise control of testing conditions, but also greatly simplifies the testing process and shortens the testing cycle, providing a solid technical foundation for efficient and accurate pathogen resistance testing.

[0062] In a further preferred embodiment of the present invention, a semiconductor refrigeration plate 42 is embedded on the transverse partition 3, with the heat-generating side of the semiconductor refrigeration plate 42 facing upward and the cooling side facing downward. Fans 43 are installed on both sides of the semiconductor refrigeration plate 42, and a plurality of heat dissipation holes 501 are provided on the upper mounting plate 5 for allowing heat to pass through the heat dissipation holes 501 to heat the thermal detection chamber.

[0063] In this embodiment, the semiconductor cooling plate 42 cleverly embedded in the transverse partition 3 is the key to regulating the temperature within the detection chamber. With the heat-generating side facing upward and the cooling side facing downward, it is assisted by a fan 43, forming a unique temperature control system. Multiple heat dissipation holes 501 on the upper mounting plate 5 ensure efficient heat dissipation, providing the necessary heating strips for the thermal detection chamber. Furthermore, the fan 43 and heat dissipation holes 501 work together to effectively dissipate heat into the thermal detection chamber, maintaining a suitable, relatively warm temperature for the culture dishes within.

[0064] In a further preferred embodiment of the present invention, two temperature sensors 44 are installed on one of the vertical partitions 2, and the probes of the two temperature sensors 44 extend into the two detection chambers respectively.

[0065] In this embodiment, two temperature sensors 44 are cleverly installed on the vertical partition 2, with their probes extending into the two detection chambers, enabling real-time monitoring of the experimental environment temperature. This design not only ensures accurate collection of temperature parameters but also provides critical data support for temperature control during the experiment. The sensitive detection of the temperature sensors 44, combined with the precise control of the semiconductor cooling plate 42, creates the ideal temperature control environment required for the experiment, greatly improving the accuracy and reliability of the experimental results.

[0066] In a further preferred embodiment of the present invention, a plurality of germicidal lamps 45 are fixedly installed on the side of the two vertical partitions 2 close to each other. The germicidal lamps 45 are located in the two detection chambers and are used to sterilize and disinfect the two detection chambers before performing resistance testing on pathogenic microorganisms.

[0067] In this embodiment, several germicidal lamps 45 are fixedly mounted on the adjacent sides of the two vertical partitions 2, providing efficient sterilization and disinfection within the testing chambers. These germicidal lamps 45, located within both chambers, ensure that the internal environment is thoroughly purified before pathogen resistance testing is conducted, eliminating potential sources of contamination and paving the way for smooth experimental execution. This design not only enhances the safety of the experimental environment but also improves the reliability and validity of the experimental results. Pre-sterilization effectively prevents interference from external bacteria, ensuring the purity and consistency of experimental conditions. The introduction of the germicidal lamps 45 not only provides strong support for preliminary experimental preparations, but also simplifies the experimental process, saves experimental time, and creates favorable conditions for the efficient conduct of pathogen resistance testing.

[0068] In a further preferred embodiment of the present invention, a control panel 101 is provided in the detection box 1 for setting parameters and controlling the operation of the equipment, and two front door panels 102 are provided on the front side of the detection box 1, corresponding to two detection chambers, for taking and placing culture dishes 26, and visual glass observation windows are provided on the two front door panels 102. The rear side of the detection box 1 is set to an opening and is installed with a rear inspection panel 103.

[0069] In this embodiment, the control panel 101 within the test chamber 1 serves as the "brain" of the entire device, responsible for parameter setting and device operation control, ensuring the accuracy and automation of the experimental process. Two front door panels 102 correspond to the two test chambers, allowing the experimenter to easily access the culture dishes 26. A visual glass observation window allows real-time monitoring of the internal conditions during the experiment, ensuring both safety and efficiency. The rear opening and removable rear access panel 103 ensure convenient equipment maintenance and troubleshooting.

[0070] It should be noted that the ratchet mechanism 41 includes a ratchet 411, a driven wheel 412, and a pawl 413. The principle of the ratchet mechanism 41 is the same as that of the ratchet mechanism on the market, which belongs to the existing mature technology. Its structural principle will not be described in detail here. Figure 17 From the perspective shown, when the ratchet wheel 411 rotates counterclockwise, it drives the driven wheel 412 to rotate via the pawl 413. When the ratchet wheel 411 rotates clockwise, the driven wheel 412 does not rotate. This ensures that when the dual-axis motor 35 is activated, only one of the rotating shafts 38 rotates, causing the first and second placement seats 4, 10 to rotate synchronously while the storage plate 25 does not rotate. Furthermore, when the storage plate 25 rotates, the first and second placement seats 4, 10 do not rotate.

[0071] The ingenious design of the ratchet mechanism 41 ensures unidirectional rotation of the rotating shaft 38, thereby enabling independent yet coordinated movement between the first and second receiving seats 4, 10, and the storage plate 25. When the connecting block 37 rotates counterclockwise under the power of the dual-axis motor 35, the ratchet 411, via the pawl 413, drives the driven wheel 412, thereby rotating one rotating shaft 38 while the other remains stationary. Conversely, clockwise rotation activates the other rotating shaft 38, achieving alternating operation of the two rotating shafts. This ensures independent movement of the first and second receiving seats 4, 10, while the storage plate 25 rotates independently when needed, without interfering with each other.

[0072] It is worth noting that the circuits, electronic components, and modules involved in the present invention are all prior art and can be fully implemented by those skilled in the art. Needless to say, the content protected by the present invention does not involve improvements to software and methods.

[0073] This solution also provides a controller, which is installed on the equipment. When in use, the controller can start each electrical device to automatically run, and automatically control the temperature of the cooling and heat generation of the semiconductor refrigeration plate 42. The power connection method of each electrical device is an existing mature technology, and the control circuit of the controller can be realized by simple programming by technicians in this field. It is a well-known technology for people in this field and will not be elaborated here.

[0074] In summary, compared with related technologies, the device of the present invention can simultaneously explore the resistance detection of pathogenic microorganisms under different control temperatures and drug concentrations. This is of great significance for the screening of new drugs and the re-evaluation of existing drugs because it can reveal changes in the sensitivity of pathogenic microorganisms to drugs, thereby guiding the formulation and optimization of clinical treatment plans.

[0075] In addition, the device of the present invention reduces human operation errors and improves the repeatability and accuracy of detection through an automated detection process.

[0076] In the several embodiments provided in this application, it should be understood that the disclosed device can be implemented in other ways.

[0077] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the scope of protection of the invention. Obviously, the embodiments described are only some embodiments of the present invention, rather than all embodiments. Based on these embodiments, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in this field can still combine, add, delete or make other adjustments to the features in the various embodiments of the present invention according to the circumstances without conflict, without making creative work, so as to obtain different other technical solutions that do not deviate from the concept of the present invention in essence, and these technical solutions also fall within the scope of protection of the present invention.

Claims

1. A pathogenic microorganism resistance detection device, characterized in that: include: A test box (1) for pathogenic microorganism resistance testing, wherein two vertical partitions (2) are fixedly installed in the test box (1), and a transverse partition (3) is fixedly installed between the two vertical partitions (2), and the transverse partition (3) divides the space between the two vertical partitions (2) into two upper and lower test chambers, namely a hot test chamber and a cold test chamber; Two first placement seats (4) are provided in the two detection chambers, and the first placement seats (4) are provided with a plurality of annular placement slots for placing a plurality of culture dishes (26) for culturing pathogenic microorganisms; The detection box (1) is provided with a drug injection mechanism for injecting a drug for detecting the resistance of pathogenic microorganisms into the culture dish (26); A first transmission mechanism is provided in the detection box (1) for causing the two first placement seats (4) to rotate simultaneously to switch the culture dishes (26); Two mounting plates (5) are fixedly installed between the two vertical partitions (2) for supporting the two first placement seats (4), and the first transmission mechanism comprises: two first central shafts (6) respectively fixedly installed on the bottom of the two first placement seats (4), the two first central shafts (6) being rotatably connected to the two mounting plates (5); a first rotating rod (7) rotatably installed on one side of one of the vertical partitions (2); four first synchronous pulleys (8) respectively fixedly sleeved on the bottom ends of the two first central shafts (6) and the first rotating rod (7), a first synchronous belt (9) being sleeved between the two first synchronous pulleys (8) at the bottom ends of the two first central shafts (6) and the two first synchronous pulleys (8) on the first rotating rod (7); wherein the first transmission mechanism is further equipped with a power driving mechanism for driving the first rotating rod (7) in the first transmission mechanism to rotate so as to realize the rotation of the first placement seat (4); A second placement seat (10) is provided above the top of the detection box (1), and a plurality of annular placement slots are provided on the second placement seat (10) for placing a plurality of medicine bottles (11) containing medicines of different concentrations, so as to provide medicines of different concentrations for pathogenic microorganism resistance detection. A second transmission mechanism is installed in the detection box (1) for driving the second placement seat (10) to rotate so as to switch different medicine bottles (11); The second transmission mechanism comprises: a second central shaft (12) fixedly mounted on the bottom of the second placement seat (10), the second central shaft (12) being rotatably connected to the top of the detection box (1); two second synchronous pulleys (13) respectively fixedly sleeved on the bottom end of the second central shaft (12) and the first rotating rod (7), a second synchronous belt (14) being sleeved between the two second synchronous pulleys (13); The top of the detection box (1) is hingedly connected to a protective box (15) with an open bottom. The protective box (15) covers the second placement seat (10) and the medicine bottle (11) thereon in the protective box (15). A U-shaped handle (201) is installed on one side of the protective box (15) for opening the protective box (15). The injection mechanism comprises: a micro-liquid pump (16) fixedly mounted on the inner wall of one side of the detection box (1) and located outside the detection room, the liquid inlet end of the micro-liquid pump (16) being connected to a liquid inlet hose (17); a liquid inlet elbow (18) fixedly connected to the other end of the liquid inlet hose (17), one end of the liquid inlet elbow (18) being connected to a straw (19) for drawing liquid medicine from a medicine bottle (11); an electric telescopic rod (20) fixedly mounted on the protection box (15), the output stem bottom end of the electric telescopic rod (20) being fixedly connected to the liquid inlet elbow (18) and being used to move vertically downward to move the straw (19) ) extends into the medicine bottle (11); a three-way pipe (21) fixedly connected to the liquid outlet end of the micro liquid pump (16), and the other two ports of the three-way pipe (21) are connected to the liquid outlet hose (22); two liquid outlet elbows (23) are fixedly mounted on a vertical partition (2), and one end of the two liquid outlet elbows (23) is connected to one end of the two liquid outlet hoses (22); two nozzles (24) are fixedly mounted on the bottom ends of the two liquid outlet elbows (23), and the two nozzles (24) are both horizontally arranged and have a plurality of liquid spray holes at the bottom, and the nozzles (24) are located directly above the corresponding culture dishes (26); A plurality of placement slots on the first placement seat (4) are each provided with a placement plate (25), a placement slot for placing a culture dish (26) is provided on the top of the placement plate (25), and a third transmission mechanism is provided in the detection box (1) for driving the corresponding placement plates (25) on the two first placement seats (4) to rotate synchronously so that the medicine can be evenly sprayed into the entire culture dish (26), and the third transmission mechanism includes: a plurality of third central shafts (27) respectively fixedly mounted on the bottom of the plurality of placement plates (25), the plurality of third central shafts (27) being rotatably connected to the two first placement seats (4); a plurality of first straight gears (28) respectively fixedly sleeved on the bottom ends of the plurality of third central shafts (27); and a plurality of first straight gears (28) respectively rotatably mounted on the two mounting plates (5). Two fourth central shafts (29) on the upper portion, the top ends of the two fourth central shafts (29) are fixedly sleeved with second spur gears (30), and the two second spur gears (30) are respectively engaged with the two first spur gears (28); a second rotating rod (31) is rotatably mounted on one side of the vertical partition (2) away from the first rotating rod (7), and two third synchronous pulleys (32) are fixedly sleeved on the second rotating rod (31); two fourth synchronous pulleys (33) are respectively fixedly sleeved on the bottom ends of the two fourth central shafts (29), and the two fourth synchronous pulleys (33) are respectively sleeved with third synchronous belts (34) on the two third synchronous pulleys (32); wherein the power driving mechanism is also used to drive the second rotating rod (31) to rotate, so as to rotate the corresponding two storage plates (25); The power drive mechanism comprises: a double-shaft motor (35) fixedly mounted on the inner wall of the bottom of the detection box (1); two connecting shafts (36) respectively fixedly mounted on the two output shafts of the double-shaft motor (35), and a connecting block (37) fixedly mounted on the ends of the two connecting shafts (36) away from each other; two rotating shafts (38) respectively rotatably mounted on the two vertical partitions (2), and a first bevel gear (39) fixedly sleeved on the bottom end of the first rotating rod (7) and one end of the corresponding rotating shaft (38), and the two first bevel gears (39) are meshed with each other; two second bevel gears (40) respectively fixedly sleeved on the second rotating rod (31) and one end of the other rotating shaft (38), and the two second bevel gears (40) are meshed with each other; wherein a ratchet mechanism (41) is connected between the rotating shaft (38) and the connecting block (37), and the two ratchet mechanisms (41) are symmetrically arranged to enable the two rotating shafts (38) to rotate only in one direction and in the opposite direction.

2. The pathogenic microorganism resistance detection device according to claim 1, wherein A semiconductor cooling plate (42) is embedded in the transverse partition (3), with the heat-generating side of the semiconductor cooling plate (42) facing upward and the cooling side facing downward. Fans (43) are installed on both sides of the semiconductor cooling plate (42), and a plurality of heat dissipation holes (501) are provided on the upper mounting plate (5) for allowing heat to pass through the heat dissipation holes (501) to heat the thermal detection chamber.

3. The pathogenic microorganism resistance detection device according to claim 1, wherein Two temperature sensors (44) are installed on one of the vertical partitions (2), and probes of the two temperature sensors (44) extend into the two detection chambers respectively.

4. The pathogenic microorganism resistance detection device according to claim 1, wherein A plurality of sterilizing lamps (45) are fixedly mounted on the sides of the two vertical partitions (2) adjacent to each other. The plurality of sterilizing lamps (45) are located in the two detection chambers and are used to sterilize and disinfect the two detection chambers before performing resistance testing on pathogenic microorganisms.

5. The pathogenic microorganism resistance detection device according to claim 1, wherein The detection box (1) is provided with a control panel (101) for setting parameters and controlling the operation of the equipment, and the front side of the detection box (1) is provided with two front door panels (102), corresponding to two detection chambers, for taking and placing culture dishes (26), and the two front door panels (102) are provided with visual glass observation windows. The rear side of the detection box (1) is set as an opening and is installed with a rear inspection panel (103).

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