Implant and implant delivery device

Abstract

The invention provides an implant and an implant conveying device. The implant conveying device comprises a puncture needle which is provided with an inner cavity arranged in a penetrating mode in the axial direction; the implant is accommodated in the inner cavity; the push rod is partially located in the inner cavity, and the implant is pushed out of the inner cavity through the push rod to be implanted into the body; wherein the implant has a non-swelled first state and a swelled second state, the outer diameter of the implant in the first state is D1, the outer diameter of the implant in the second state is D2, the inner diameter of the puncture needle is D3, and D1 < D3 < D2. According to the implant and the conveying device, a tissue incision can be reduced, and tissue damage is reduced.

Description

Technical Field

[0001] The present application relates to the field of medical biomaterial technology, and in particular to an implant and an implant delivery device. Background Art

[0002] With the continuous advancement of medical technology in recent years, minimally invasive techniques have been gradually applied to treat various diseases. Compared with conventional treatments, minimally invasive surgery results in smaller wounds, shorter recovery periods, and significantly fewer adverse reactions and complications. However, this technology is still under development, and many challenges remain to be addressed.

[0003] In minimally invasive techniques, implants are introduced into the body using a delivery system or by pre-forming an incision in the tissue. The implant is then carried by the delivery system and delivered through the incision to a specific location in the tissue. However, any incision causes some damage to the tissue, and making the incision as small as possible while ensuring safety and effectiveness is a common goal within the industry. Summary of the Invention

[0004] In response to the problems existing in the prior art, the embodiments of the present application provide an implant and an implant delivery system that can effectively reduce the size of the incision during the implantation process into the tissue.

[0005] In a first aspect, an embodiment of the present application provides an implant delivery system, comprising:

[0006] The puncture needle has an inner cavity provided through the axial direction;

[0007] an implant housed in the lumen; and

[0008] A push rod is partially located in the inner cavity, and the implant is pushed out of the inner cavity by the push rod to be implanted into the body; wherein,

[0009] The implant has a first state in which the implant is not swollen and a second state in which the implant is swollen. The outer diameter of the implant in the first state is D1, the outer diameter of the implant in the second state is D2, the inner diameter of the puncture needle is D3, and D1<D3<D2.

[0010] The outer diameter D1 of the implant in the first state, the outer diameter D2 in the second state, and the inner diameter D3 of the puncture needle are limited to satisfy D1<D3<D2. The implant can be well accommodated in the inner cavity of the puncture needle in the first state. When the implant is implanted into the tissue through the puncture needle, the implant absorbs liquid and swells to a specified size. As a result, the diameter of the implant when it is not swollen can be reduced as much as possible, thereby minimizing the tissue incision and reducing damage to the tissue.

[0011] In some embodiments, 0<D2-D1≤0.5mm.

[0012] In some embodiments, the outer diameter of the puncture needle is D4, and D4≤D2.

[0013] In some embodiments, 0.06 mm ≤ D1 ≤ 0.3 mm.

[0014] In some embodiments, 0.18 mm ≤ D2 ≤ 0.6 mm.

[0015] In some embodiments, 0.1 mm ≤ D3 ≤ 0.3 mm.

[0016] In some embodiments, 0.18 mm ≤ D4 ≤ 0.6 mm.

[0017] In some embodiments, the swelling rate of the implant is from 1 min to 60 min.

[0018] In some embodiments, the swelling rate of the implant is from 5 min to 30 min.

[0019] In some embodiments, the material of the implant includes one or more of sodium alginate, collagen, cellulose, dextran, gelatin, chitin, chitosan, sodium hyaluronate, polyvinyl alcohol, polyester, polyurethane, polyurea, and hydrophilic acrylic acid.

[0020] In some embodiments, the surface of the implant has a coating, and the material of the coating includes one or more of expanded polytetrafluoroethylene, perfluoroethylene propylene copolymer, polyparaxylene, polyester, and polyurethane.

[0021] In some embodiments, the coating film has a thickness of 0.01 μm to 3 μm.

[0022] In some embodiments, the coating film has a thickness of 0.1 μm to 1.5 μm.

[0023] In some embodiments, the implant further comprises an outer coating, wherein the outer coating comprises one or more of a drug-loaded coating, an anticoagulant coating, and an anti-cell adhesion coating.

[0024] In some embodiments, the elastic modulus of the implant is 10 2 Pa to 10 6 Pa.

[0025] In some embodiments, the implant is a drainage implant having a drainage channel.

[0026] In some embodiments, the implant is an occlusive implant having a porous structure.

[0027] In a second aspect, an embodiment of the present application provides an implant having a first unswollen state and a second swollen state. The outer diameter of the implant in the first state is D1, and the outer diameter of the implant in the second state is D2, where D1<D2.

[0028] In some embodiments, the material of the implant includes one or more of sodium alginate, collagen, cellulose, dextran, gelatin, chitin, chitosan, sodium hyaluronate, polyvinyl alcohol, polyester, polyurethane, polyurea, and hydrophilic acrylic acid.

[0029] In some embodiments, the material of the covering film includes one or more of expanded polytetrafluoroethylene, perfluoroethylene propylene copolymer, polyparaxylene, polyester, and polyurethane. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0031] Figure 1 Schematic diagram of the structure of the implant delivery device in some embodiments of the present application.

[0032] Figure 2 This is a schematic diagram comparing the sizes of the implant before and after swelling and the puncture needle in some embodiments of the present application.

[0033] Figure 3 Schematic diagram comparing the size of the implant before and after swelling and the puncture needle in other embodiments of the present application.

[0034] In the accompanying drawings, the drawings are not necessarily drawn to scale.

[0035] The reference numerals are as follows: 1. puncture needle; 2. implant; 3. push rod. DETAILED DESCRIPTION

[0036] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In the detailed description below, many specific details are set forth in order to provide a comprehensive understanding of the present application. However, it will be apparent to those skilled in the art that the present application can be implemented without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the present application by illustrating examples of the present application. In the accompanying drawings and the following description, at least some of the well-known structures and technologies are not shown in order to avoid unnecessary ambiguity in the present application; and, for clarity, the sizes of some structures may be exaggerated. In addition, the features, structures, or characteristics described below may be combined in any suitable manner in one or more embodiments.

[0037] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish an entity or operation from another entity or operation, and do not necessarily require or imply that there is any such actual relationship or order between these entities or operations. In the description of the present application, it should be noted that, unless otherwise stated, the meaning of "plurality" is more than two. Moreover, the term "comprises", "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that the process, method, article or equipment comprising a series of elements not only include those elements, but also include other elements not clearly listed, or also include elements inherent to such process, method, article or equipment. In the absence of more restrictions, the elements limited by the statement "comprises..." do not exclude the presence of other identical elements in the process, method, article or equipment comprising the elements.

[0038] As described in the background, implants are typically implanted via a delivery system. These delivery systems typically have a longitudinally extending needle mechanism at the distal end. This needle mechanism typically includes a needle-shaped guide mechanism, such as an injection needle or puncture needle. The size of the tissue incision depends on the outer ring dimensions of the needle mechanism. Therefore, to minimize the size of the tissue incision, the outer ring dimensions of the needle mechanism must be reduced. However, due to the characteristics of materials such as medical stainless steel, the wall thickness of the needle mechanism also has certain size limitations. Therefore, a feasible method for reducing the outer ring dimensions of the needle mechanism is to reduce the inner lumen dimensions. Because the inner lumen dimensions of the needle mechanism need to accommodate the implant, the size of the implant is one of the main factors limiting the inner lumen dimensions of the needle mechanism. However, to function effectively, implants must be of a certain size. Designing an implant too small can significantly reduce its performance, making it difficult to effectively function. Therefore, resolving the conflict between implant size and tissue incision is a pressing issue.

[0039] The embodiments of the present application provide an implant and an implant delivery device. Figure 1and Figure 2 , the implant delivery device comprises:

[0040] The puncture needle 1 has an inner cavity extending through the axial direction;

[0041] an implant 2, housed in the inner cavity; and

[0042] The push rod 3 is partially located in the inner cavity, and the implant is pushed out of the inner cavity by the push rod to be implanted into the body; wherein,

[0043] The implant has a first state without swelling and a second state after swelling. The outer diameter of the implant in the first state is D1, the outer diameter of the implant in the second state is D2, the inner diameter of the puncture needle is D3, and D1<D3<D2.

[0044] In the present application, the outer diameter D1 of the implant in the first state and the outer diameter D2 of the implant in the second state are both the average values ​​of the outer diameters of the implant in their respective states. The implant in the embodiment of the present application is an implant that can swell. When the implant is not implanted into the body tissue, it maintains the first state of non-swelling. After the implant is implanted into the body tissue, the implant can absorb liquids such as tissue fluid to swell, increase in volume, and reach the second state after swelling. The outer diameter D1 of the implant in the first state, the outer diameter D2 of the second state, and the inner diameter D3 of the puncture needle are limited to satisfy D1<D3<D2. The implant can be well accommodated in the inner cavity of the puncture needle in the first state. When the implant is implanted into the tissue through the puncture needle, the implant absorbs liquid and swells to a specified size. Therefore, the diameter of the implant when it is not swollen can be reduced as much as possible, thereby minimizing the tissue incision and reducing damage to the tissue.

[0045] In the embodiment of the present application, the implant assembled in the inner cavity of the puncture needle can be pushed out and implanted into the body by the push rod. In the process of pushing the implant out by the push rod, the puncture needle can be fixed, and external force is applied to the push rod to make it move to push the implant out; or the push rod can be fixed, and external force is applied to the puncture needle to make the puncture needle and the push rod produce relative movement and thus push the implant out. The specific pushing method can be selected according to actual needs and is not limited by the embodiment of the present application.

[0046] In some embodiments, the outer diameter D1 of the implant in the first state and the outer diameter D2 of the implant in the second state satisfy: 0< D2 − D1 ≤ 0.5 mm.

[0047] By limiting the difference between the outer diameter of the implant in the first state and the outer diameter of the implant in the second state to be within the above range, the implant has an appropriate swelling degree and can swell to an appropriate size after being implanted in body tissue.

[0048] Reference Figure 3In some embodiments, the outer diameter of the puncture needle is D4, where D4 ≤ D2. By limiting the outer diameter of the puncture needle to be smaller than the outer diameter of the swollen implant, the size of the puncture needle can be further reduced, thereby further reducing the tissue incision and minimizing tissue damage.

[0049] It should be noted that in Figure 2 and Figure 3 In the figure, for the convenience of comparison, the puncture needle in the state after the implant is swollen uses the axial cross-section, and the implant uses the radial cross-section; In addition, Figure 2 and Figure 3 It is only used to illustrate the size relationship between the implant and the puncture needle in different states in some embodiments of the present application, and does not constitute a limitation on the specific size and assembly relationship between the implant and the puncture needle.

[0050] In some embodiments, the outer diameter D1 of the implant in the first state can be 0.06 mm to 0.3 mm. For example, the outer diameter D1 of the implant in the first state can be 0.06 mm, 0.07 mm, 0.08 mm, 0.09 mm, 0.10 mm, 0.12 mm, 0.15 mm, 0.18 mm, 0.20 mm, 0.23 mm, 0.25 mm, 0.27 mm, 0.28 mm, 0.3 mm, or any range thereof.

[0051] In some embodiments, the outer diameter D2 of the implant in the second state can be 0.18 mm to 0.6 mm. For example, the outer diameter D2 of the implant in the second state can be 0.18 mm, 0.20 mm, 0.25 mm, 0.30 mm, 0.35 mm, 0.40 mm, 0.45 mm, 0.50 mm, 0.55 mm, 0.6 mm, or any range thereof.

[0052] In some embodiments, the inner diameter D3 of the puncture needle can be 0.1 mm to 0.3 mm. For example, the inner diameter D3 of the puncture needle can be 0.1 mm, 0.12 mm, 0.15 mm, 0.18 mm, 0.20 mm, 0.23 mm, 0.25 mm, 0.27 mm, 0.3 mm, or a range thereof.

[0053] In some embodiments, the outer diameter D4 of the puncture needle may be 0.18 mm to 0.6 mm. For example, the outer diameter D4 of the puncture needle may be 0.18 mm, 0.20 mm, 0.25 mm, 0.30 mm, 0.35 mm, 0.40 mm, 0.45 mm, 0.50 mm, 0.55 mm, 0.6 mm, or any range thereof.

[0054] In some embodiments, the swelling rate of the implant may be 1 min to 60 min, optionally 5 min to 30 min, and more optionally 8 min to 25 min.

[0055] In this application, the "swelling rate" of an implant refers to the time it takes for the implant to swell from a first state to a second state after absorbing liquid. By limiting the implant's swelling rate to the aforementioned range, the implant can, on the one hand, swell to a specified size after implantation. Furthermore, by regulating the implant's swelling rate, damage to the implant, which can occur when the implant is partially within the tissue and partially within the puncture needle, can be avoided. Furthermore, by regulating the implant's swelling rate, the swelling of each part of the implant can be made more uniform, improving the implant's effectiveness after implantation.

[0056] In some embodiments, the material of the implant may include one or more of sodium alginate, collagen, cellulose, dextran, gelatin, chitin, chitosan, sodium hyaluronate, polyvinyl alcohol, polyester, polyurethane, polyurea, and hydrophilic acrylic acid.

[0057] Implants are made from biocompatible materials that exhibit good affinity with the implanted tissue, minimizing the risk of side effects and other adverse reactions. Furthermore, by combining these materials, the swelling rate and degree of the implant can be further regulated. By blending and cross-linking one or more of these materials to form an implant, the implant's swelling rate can be controlled within an appropriate range.

[0058] In some embodiments, the surface of the implant has a coating, and the material of the coating includes one or more of expanded polytetrafluoroethylene (ePTFE), perfluoroethylene propylene copolymer (FEP), parylene, polyester, and polyurethane.

[0059] The coating film can regulate the swelling rate of the implant. By setting a coating layer on the surface of the implant, the rapid absorption and swelling of the implant after implantation into the tissue in the body can be inhibited, the swelling equilibrium time of the implant can be prolonged, and the implant will not swell immediately after implantation into the body, thereby avoiding pressure on the puncture needle and damage to the implant itself.

[0060] In some embodiments, the coating film may have a thickness of 0.01 μm to 3 μm; alternatively, the coating film may have a thickness of 0.1 μm to 1.5 μm; more alternatively, the coating film may have a thickness of 0.5 μm to 1.2 μm.

[0061] The thickness of the coating film is limited to the above range, which can better limit the swelling of the implant due to liquid absorption, so that the implant has a suitable swelling rate and reduce damage to the puncture needle and the implant itself during the implantation process.

[0062] In some embodiments, the implant further includes an outer coating, disposed on the outermost surface of the implant. The outer coating may be one or more of a drug-loaded coating, an anticoagulant coating, or an anti-cell adhesion coating. The outer coating can provide various benefits for the implant. For example, the drug-loaded coating can carry targeted drugs for drug delivery or long-term sustained release, thereby further enhancing the efficacy of the implant.

[0063] In some embodiments, the outer coating may contain a drug, which may be one or more of mitomycin, 5-F uracil, an anti-vascular endothelial growth factor (VEGF) drug, an anticoagulant, an antimetabolite, rapamycin, and paclitaxel. Different effects can be achieved by varying the drug content of the outer coating.

[0064] In some embodiments, the elastic modulus of the implant may be 10 2 Pa to 10 6 Pa. By limiting the elastic modulus of the implant to the above range, it has an elastic modulus close to that of human tissue, which can further improve the affinity with the implanted tissue. For example, when the implant is used in brain tissue or nerve tissue, the elastic modulus of the implant can be controlled within 10 2 Pa to 10 3 Pa; when the implant is used for liver, fat, loose muscle, breast tissue, etc., the elastic modulus of the implant can be controlled within 10 3 Pa to 10 4 a; When the implant is used in tissues such as dermis, connective tissue, and contractile muscle, the elastic modulus of the implant can be controlled within 10 5 Pa to 10 6 Pa. Therefore, the elastic modulus of the implant can be adjusted according to the different implantation sites, further improving the application range of the implant.

[0065] In some embodiments, the implant may be one or more of an ocular drainage implant and a tissue incision sealing implant. The structure, shape, and morphology of the implant may be designed according to the site of action of the implant.

[0066] In some embodiments, the implant may have a drainage channel extending axially therethrough, so that the implant can be implanted as an ocular aqueous humor drainage device.

[0067] In some embodiments, the implant may be a solid porous structure, utilizing the pore structure to achieve a fluid drainage effect.

[0068] Example

[0069] Some specific embodiments of the implants and implant delivery devices provided herein are provided below. The embodiments described below are exemplary and are intended only to explain the present application and are not to be construed as limiting the present application. Where specific techniques or conditions are not specified in the embodiments, the techniques or conditions described in the literature in the art or in accordance with the product specifications were used. Reagents or instruments used without manufacturer specified are all commercially available conventional products.

[0070] Example 1

[0071] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0072] The inner diameter D3 of the puncture needle is 0.21 mm, and the outer diameter D4 of the puncture needle is 0.33 mm.

[0073] The implant is a drainage tube with a drainage channel. The material of the drainage tube is cross-linked collagen. The outer diameter D1 of the unswollen drainage tube is 0.17 mm, and the outer diameter of the swollen drainage tube is 0.25 mm. The outer surface of the drainage tube is coated with an FEP film with a thickness of 0.1 μm. The swelling rate is 5 minutes.

[0074] Example 2

[0075] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0076] The inner diameter D3 of the puncture needle is 0.18 mm, and the outer diameter D4 of the puncture needle is 0.3 mm.

[0077] The implant is a drainage tube with a drainage channel. Made of cross-linked collagen, the tube has an unswollen outer diameter (D1) of 0.13 mm and a swollen outer diameter of 0.2 mm. The outer surface of the tube is coated with a 0.5 μm thick Parylene film. The swelling rate is 10 minutes.

[0078] Example 3

[0079] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0080] The inner diameter D3 of the puncture needle is 0.14 mm, and the outer diameter D4 of the puncture needle is 0.26 mm.

[0081] The implant is a drainage tube with a drainage channel. The material of the drainage tube is hydrophilic acrylic. The outer diameter D1 of the unswollen tube is 0.09 mm, and the outer diameter after swelling is 0.18 mm. The outer surface of the drainage tube is coated with a Parylene film with a thickness of 1.0 μm. The swelling rate is 20 minutes. The outer surface of the film is coated with heparin.

[0082] Example 4

[0083] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0084] The inner diameter D3 of the puncture needle is 0.26 mm, and the outer diameter D4 of the puncture needle is 0.41 mm.

[0085] The implant is a drainage tube with a drainage channel. Made of inexpensive polyvinyl alcohol, the tube has an unswollen outer diameter (D1) of 0.24 mm and a swollen outer diameter of 0.4 mm. The outer surface of the tube is coated with a 2.0 μm thick Parylene film. The swelling rate is 35 minutes. The outer surface of the film is coated with mitomycin.

[0086] Example 5

[0087] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0088] The inner diameter D3 of the puncture needle is 0.30 mm, and the outer diameter D4 of the puncture needle is 0.51 mm.

[0089] The implant is a drainage tube with a drainage channel. The material of the drainage tube is cross-linked sodium alginate. The outer diameter D1 of the unswollen drainage tube is 0.28 mm, and the outer diameter after swelling is 0.53 mm. The outer surface of the drainage tube is coated with a Parylene film with a thickness of 3.0 μm. The swelling rate is 60 minutes. The outer surface of the film is coated with heparin.

[0090] Example 6

[0091] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0092] The inner diameter D3 of the puncture needle is 0.18 mm, and the outer diameter D4 of the puncture needle is 0.3 mm.

[0093] The implant is a drainage tube with a drainage channel. The tube is made of a cross-linked gelatin and hydrophilic acrylic acid. The unswollen outer diameter D1 of the tube is 0.15 mm, and the swollen outer diameter is 0.24 mm. The outer surface of the tube is coated with a Parylene film with a thickness of 1.0 μm. The swelling rate is 15 minutes. The outer surface of the film is coated with heparin.

[0094] Example 7

[0095] An implant delivery device includes a puncture needle and a push rod. The puncture needle has an inner cavity arranged along the axial direction. The inner cavity of the puncture needle accommodates an implant. The push rod is partially located in the inner cavity of the puncture needle. The implant can be pushed out of the inner cavity by the push rod to be implanted into the body.

[0096] The inner diameter D3 of the puncture needle is 0.21 mm, and the outer diameter D4 of the puncture needle is 0.33 mm.

[0097] The implant has a solid porous structure and is made of cross-linked collagen. The unswollen outer diameter D1 of the implant is 0.17 mm, and the swollen outer diameter is 0.25 mm. The outer surface of the implant is coated with an FEP film with a thickness of 0.5 μm. The swelling rate is 10 minutes.

[0098] Although the present application has been described with reference to preferred embodiments, various modifications may be made thereto and components may be substituted with equivalents without departing from the scope of the present application. In particular, the various technical features described in the various embodiments may be combined in any manner as long as there are no structural conflicts. The present application is not limited to the specific embodiments disclosed herein, but encompasses all technical solutions within the scope of the claims.

Claims

1. An implant delivery device, characterized in that: include: The puncture needle has an inner cavity which is arranged to penetrate along the axial direction; an implant, accommodated in the inner cavity; as well as A push rod is partially located in the inner cavity, and the implant is pushed out of the inner cavity by the push rod to be implanted in the body; wherein, The implant has a first state in which the implant is not swollen and a second state in which the implant is swollen. The outer diameter of the implant in the first state is D1, the outer diameter of the implant in the second state is D2, the inner diameter of the puncture needle is D3, and D1<D3<D2.

2. The implant delivery device according to claim 1, characterized in that 0<D2-D1≤0.5mm.

3. The implant delivery device according to claim 1, characterized in that: The outer diameter of the puncture needle is D4, and D4≤D2.

4. The implant delivery device according to any one of claims 1 to 3, characterized in that: 0.06mm≤D1≤0.3mm; and / or 0.18mm≤D2≤0.6mm; and / or 0.1mm≤D3≤0.3mm; and / or 0.18mm≤D4≤0.6mm.

5. The implant delivery device according to claim 1, characterized in that: The swelling rate of the implant is from 1 min to 60 min, and can be optionally from 5 min to 30 min.

6. The implant delivery device according to claim 1, characterized in that The material of the implant includes one or more of sodium alginate, collagen, cellulose, dextran, gelatin, chitin, chitosan, sodium hyaluronate, polyvinyl alcohol, polyester, polyurethane, polyurea, and hydrophilic acrylic acid.

7. The implant delivery device according to claim 1, characterized in that: The surface of the implant is provided with a coating film, and the material of the coating film includes one or more of expanded polytetrafluoroethylene, perfluoroethylene-propylene copolymer, polyparaxylene, polyester, and polyurethane.

8. The implant delivery device according to claim 7, characterized in that: The coating film has a thickness of 0.01 μm to 3 μm, and can be optionally 0.1 μm to 1.5 μm.

9. The implant delivery device according to claim 1, characterized in that: The implant further comprises an outer coating, which comprises one or more of a drug-loaded coating, an anticoagulant coating, and an anti-cell adhesion coating.

10. The implant delivery device according to claim 1, wherein: The elastic modulus of the implant is 10 2 Pa to 10 6 Pa.

11. The implant delivery device according to any one of claims 1 to 10, characterized in that: The implant is a drainage implant having a drainage channel; or The implant is a blocking implant with a porous structure.

12. An implant, characterized in that The implant has a first state where the implant is not swollen and a second state where the implant is swollen. The outer diameter of the implant in the first state is D1, and the outer diameter of the implant in the second state is D2, where D1<D2.

13. The implant according to claim 12, characterized in that The material of the implant includes one or more of sodium alginate, collagen, cellulose, dextran, gelatin, chitin, chitosan, sodium hyaluronate, polyvinyl alcohol, polyester, polyurethane, polyurea, and hydrophilic acrylic acid.

14. The implant according to claim 12, characterized in that The surface of the implant is provided with a coating film, and the material of the coating film includes one or more of expanded polytetrafluoroethylene, perfluoroethylene-propylene copolymer, polyparaxylene, polyester, and polyurethane.

Images