Instant red-removing composition and application thereof, cosmetic composition and preparation method thereof

Abstract

The invention provides an instant red-removing composition and application thereof, a cosmetic composition and a preparation method thereof, and relates to the technical field of cosmetics. The instant redness-removing composition comprises the magnolin and the fibronectin, and compared with single use of the magnolin or compound use of the magnolin and the redness-removing agent, the instant redness-removing composition comprising the magnolin and the fibronectin is high in safety and can quickly relieve and eliminate the phenomenon that the skin becomes red. The cosmetic composition capable of instantly removing redness is high in stability, can solve the problem and demand of instantly removing redness on different skins, is simple and convenient in preparation method and high in operability, and has a wide market prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to an instant redness-removing composition and application thereof, a cosmetic composition and a preparation method thereof. Background Art

[0002] Normal skin has an even complexion, a natural luster, a firm and elastic feel, good tolerance, and is not prone to allergic symptoms. Generally speaking, the normal skin color of Chinese people is fair with a rosy complexion, but if they encounter stress factors or disease factors, the skin color will turn red, that is, the skin will turn red or red. If not treated, it will not only affect the senses, but may also damage the skin barrier or cause other potential health problems.

[0003] Skin redness is mainly related to the high reactivity of skin blood vessels caused by inflammatory factors. Some physical factors, such as large temperature differences, can also lead to accelerated blood flow and even capillary dilation. There are also a few special cases of redness, such as congenital red blood streak problems, "highland redness", facial flushing caused by changes in hormone levels in the body, and hormone face caused by the abuse of glucocorticoids. The causes of skin redness are varied, including skin discomfort such as redness and itching caused by sensitive skin, as well as skin damage caused by ultraviolet and infrared radiation. Medical cosmetic treatments or excessive cleaning can also lead to damaged skin barriers, sensitive skin or skin lesions (such as psoriasis and eczema), and the skin may also experience skin physiological disorders such as redness, itching, and pain.

[0004] In the process of exploring the mechanism of skin redness removal, researchers found that when the skin barrier is damaged, if the skin inflammatory factors, neurotransmitters and other factors related to skin redness can be restored to the normal physiological range in time, the recovery of the skin barrier will be significantly accelerated, and the skin redness will be rapidly improved; this is why the main additives of many anti-redness / redness-reducing products on the market today also work from the mechanism of inhibiting the release of inflammatory factors. Some products also add some raw material groups that inhibit capsaicin receptors, reduce the effects of alternating hot and cold on the skin, and other related mechanisms. As people pay more attention to skin health trials,

[0005] Instant redness removal can be further divided into anti-redness and instant redness fading. Anti-redness focuses on preventing skin redness and is suitable for scenarios that may damage the skin, such as those that require medical beauty treatments; instant redness fading focuses on quickly reducing and eliminating skin redness. The main ingredients added to many anti-redness / redness fading products also work by inhibiting the release of inflammatory factors. Some raw material groups that inhibit capsaicin receptors and reduce the effects of alternating hot and cold on the skin are also added. In addition, as consumers pay more attention to skin health, the demand for redness removal products has not only actual redness removal effects, but also puts forward new requirements for the speed of improving skin redness, and they expect to get instant improvement results. Summary of the invention

[0006] In view of the deficiencies in the prior art, the present invention discloses an instant redness-removing composition and its application, a cosmetic composition and its preparation method. The instant redness-removing composition of the present invention has simple ingredients and high safety, can quickly reduce and eliminate the phenomenon of redness of skin color, and is suitable for the preparation of related cosmetics.

[0007] In order to achieve the above technical objectives, on the one hand, the present invention provides an instant redness-removing composition, which includes magnolin and fibronectin.

[0008] Based on exploratory experiments, the research and development team of the present invention discovered that magnolia is a component with the effect of removing redness from the skin, but its redness-removing effect is not good when used alone. The research and development team tried to enhance the redness-removing effect of magnolia by compounding the redness-removing agent with magnolia, such as saffron extract, but the experimental results did not meet expectations: compared with the technical solution of using magnolia alone, the technical solution of compounding magnolia and redness-removing agent did not clearly show a synergistic redness-removing effect. Based on this, the research and development team of the present invention further carried out a large number of exploratory experiments, trying to compound magnolia with other functional components. It was unexpectedly discovered in the experiment that the composition formed by compounding magnolia and fibronectin has an excellent redness-removing effect, which is significantly better than the technical solution of using magnolia alone, and the composition has high redness-removing efficiency, safe raw materials, and can quickly alleviate and eliminate the redness of the skin color, thus proposing the above technical solution.

[0009] The embodiments and comparative examples of the present invention show that the technical solution of the present invention has the effect of synergistically inhibiting the expression of TRPV1, and has the efficacy of instantly removing redness, repairing and improving skin conditions.

[0010] In a further example of the present invention, the ratio of magnolia resin and fibronectin in the above technical solution was explored and optimized. Optionally, the weight ratio of the magnolia resin to the fibronectin is 1:0.02-1.0. The research and development team found through experiments that when the amount of fibronectin added is less than 0.02 times the quality of magnolia resin, the redness removal effect is poor; when the amount of fibronectin added is higher than 1.0 times the quality of magnolia resin, the stability of the composition is poor and the cost is too high; when the amount of fibronectin added is within the range of 0.02-1.0 of the quality of magnolia resin, the redness removal effect of the instant redness removal composition can be significantly higher than the redness removal effect of the technical solution using magnolia resin alone. In some optional examples of the present invention, the weight ratio of the magnolia resin to the fibronectin is preferably 1:(0.15-0.6), and further preferably 1:0.15.

[0011] It should be noted that the present invention is not limited to the preparation method of the instant redness-removing composition. In an optional example of the present invention, the instant redness-removing composition is prepared by uniformly mixing magnolia resin and fibronectin in proportion; in an optional example of the present invention, the instant redness-removing composition is prepared by respectively adding magnolia resin and fibronectin to a solvent, and mixing them uniformly by stirring, wherein the solvent can be selected from at least one of 1,3-propylene glycol, butylene glycol, glycerol, 1,2-hexanediol, and water.

[0012] On the other hand, the present invention provides the use of the instant redness-removing composition in the preparation of cosmetics.

[0013] Optionally, the cosmetics are soothing cosmetics, cosmetics for skin after sun exposure, or cosmetics for repairing skin after medical and cosmetic treatments. The instant redness-removing composition of the present invention can be used for the preparation of soothing cosmetics, cosmetics for repairing skin after sun exposure, and cosmetics for repairing skin after medical and cosmetic treatments. The prepared cosmetics are suitable for use on sensitive skin.

[0014] Preferably, the cosmetics include any one of water-based agents, emulsions, creams, facial masks, gels, and essences.

[0015] On the other hand, the present invention provides a cosmetic composition for instantly removing redness, comprising the instant redness removing composition and a moisturizer, an emulsifier, a thickener, a preservative and a pH adjuster, with the balance being water.

[0016] The cosmetic composition of the present invention enhances the stability of the instant redness-removing composition and improves the compatibility between the instant redness-removing composition and other ingredients through synergy with matrix components including moisturizers, emulsifiers and thickeners, thereby increasing the efficiency of transdermal delivery and absorption of the instant redness-removing composition.

[0017] Further, the emollients include tri(ethylhexanoic acid)glyceryl, caprylic / capric triglyceride, isononyl isononanoate, dibutyl adipate, C12-15 alkyl benzoate, coconut oil alcohol-caprylate / caprate, propyl heptyl caprylate, coconut oil glyceryl, isotridecyl isononanoate, squalane, tri(ethylhexanoic acid)glyceryl, triisostearate, neopentyl glycol diheptanoate, isooctyl palmitate, isopropyl palmitate, propylene glycol dibenzoate, diheptyl succinate, shea butter, cetyl alcohol, polyol At least one of dimethicone, cyclopentasiloxane, cyclohexasiloxane, phenethyl benzoate, pentaerythrityl tetra(ethylhexanoate), diisopropyl sebacate, olive oil, grape seed oil, white meadowfoam seed oil, avocado oil, corn oil, squalane, dicaprylyl carbonate, isopropyl myristate, hydrogenated polydecene, hydrogenated polyisobutene, sunflower seed oil, undecane, tridecane, isohexadecane, stearic acid, jojoba seed oil, lanolin, paraffin, microcrystalline wax and beeswax; preferably caprylic / capric triglyceride Esters, Isononyl Isononanoate, Dibutyl Adipate, C12-15 Alkyl Benzoate, Coco-Caprylate / Caprate, Propylheptyl Caprylate, Glyceryl Cocoate, Squalane, Isooctyl Palmitate, Isopropyl Palmitate, Butyrospermum Parkii Butter, Cetyl Alcohol, Dimethicone, Cyclopentasiloxane, Cyclohexasiloxane, Hydrogenated Polyisobutene, Pentaerythrityl Tetraethylhexanoate, Olive Oil, Limnanthes Alba Seed Oil, Avocado Oil, Squalane, Dicaprylyl Carbonate, Isopropyl Myristate, Helianthus Annuus Seed Oil , isohexadecane, and stearic acid; preferably at least one of polyglyceryl-6 stearate, polyglyceryl-6 behenate, PEG-100 stearate, glyceryl stearate, cetearyl olive oil ester, sorbitan olive oil ester, sorbitan oleate, lecithin, cetearyl glucoside, C12-20 alkyl glucoside, sorbitan stearate, glyceryl stearate, glyceryl stearate SE, ethylene glycol distearate, monoglyceride lactate, and sorbitan monotartrate.

[0018] Further, the emulsifier includes polyglyceryl-6 stearate, polyglyceryl-6 behenate, PEG-100 stearate, glyceryl stearate, cetearyl olive oil ester, sorbitan olive oil ester, sorbitan oleate, glyceryl stearate citrate, potassium cetyl phosphate, sodium stearoyl glutamate, cetearyl glucoside, C12-20 alkyl glucoside, steareth-2, steareth-21, sorbitan stearate, polysorbate-20, polysorbate-60, polysorbate-80, trideceth-6, PEG-60 hydrogenated castor oil, PEG-9 polydimethylsiloxyethyl polydimethicone, sorbitan olive oil ester, PPG-13-decyltetradecyl alcohol polyether-24, sorbitan monoisostearate, C10-C22 At least one of fatty acids, monoglyceryl citrate, glyceryl stearate, glyceryl stearate SE, glyceryl stearate citrate, isostearyl glyceryl ether, potassium cetyl phosphate, lecithin, methyl glucose sesquistearate, lactic acid monoglyceride, acetate monoglyceride, citric acid monoglyceride, diacetyl tartaric acid monoglyceride, lactic acid monoglyceride, tartaric acid monoglyceride, Na salt of lauryl sulfate, and sodium cetyl phosphate; preferably at least one of polyglyceryl-6 stearate, polyglyceryl-6 behenate, PEG-100 stearate, glyceryl stearate, cetearyl olive oil ester, sorbitan olive oil ester, sorbitan oleate, lecithin, cetearyl glucoside, C12-20 alkyl glucoside, sorbitan stearate, glyceryl stearate, and glyceryl stearate SE;

[0019] Further, the thickener includes at least one of carbomer, xanthan gum, hydroxyethyl cellulose, hydroxypropyl cellulose, sphingomonas fermentation product extract, acrylic acid (ester) / C10 30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer, sodium polyacryloyldimethyl taurate, sodium polyacrylate grafted starch, dextrin palmitate, gum arabic, disteardimethyl ammonium hectorite, polyethylene glycol 14M, polyethylene glycol 90M and succinoglycan; preferably at least one of carbomer, xanthan gum, hydroxyethyl cellulose, sphingomonas fermentation product extract, acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer.

[0020] Furthermore, the preservative includes at least one of phenoxyethanol, benzyl alcohol, phenylethyl alcohol, potassium sorbate, sodium benzoate, chlorphenesin, 1,2-hexanediol, caprylyl glycol and p-hydroxyacetophenone; preferably p-hydroxyacetophenone and 1,2-hexanediol.

[0021] Furthermore, the pH regulator includes at least one of triethanolamine, arginine, sodium hydroxide, potassium hydroxide, tromethamine, disodium EDTA, citric acid and sodium citrate; preferably disodium EDTA.

[0022] Furthermore, the weight ratio of magnoliavine, fibronectin, emollient, emulsifier, thickener, preservative and pH adjuster in the instant redness-removing cosmetic composition can be selected as (0.001-1): (0.0001-1): (1-50): (0.1-10): (0.1-10): (0.01-2): (0.01-3); in the optional instant redness-removing cosmetic composition of the present invention, the weight percentage of magnoliavine, fibronectin, emollient, emulsifier, thickener, preservative and pH adjuster is (0.001-1%): (0.0001-1%): (1-50%): (0.1-10%): (0.1-10%): (0.01-2%): (0.01-3%).

[0023] Furthermore, the weight ratio of magnolia, fibronectin, emollient, emulsifier, thickener, preservative and pH adjuster in the cosmetic composition is preferably (0.01-0.1): (0.001-0.1): (5-30): (0.2-5): (0.2-8): (0.1-2): (0.05-2); in the optional instant redness-removing cosmetic composition of the present invention, the weight percentages of magnolia, fibronectin, emollient, emulsifier, thickener, preservative and pH adjuster are (0.01-0.1%): (0.001-0.1%): (5-30%): (0.2-5%): (0.2-8%): (0.1-2%): (0.05-2%).

[0024] Furthermore, the instant redness-removing cosmetic composition also includes functional ingredients; the functional ingredients include at least one of antioxidants, moisturizers, anti-wrinkle agents, whitening agents, soothing agents, and skin conditioners. By compounding the instant redness-removing composition with different functional ingredients according to different skin problems or needs, the effect of the overall cosmetic composition is synergistically enhanced.

[0025] Furthermore, the oxidant comprises at least one of ascorbic acid, ubiquinone, ergothioneine and idebenone; preferably ergothioneine.

[0026] Furthermore, the moisturizing agent includes at least one of glycerol, dipropylene glycol, 1,3-butylene glycol, 1,3-propylene glycol, propylene glycol, 1,2-pentanediol, betaine, glyceryl glucoside, methyl gluceth 20, glyceryl glucoside 26, trehalose, sucrose, mannitol, rhamnose, xylitol, hyaluronic acid, sodium hyaluronate, polyethylene glycol-8, methyl gluceth-10, PEG / PPG-17 / 6 copolymer, sodium polyglutamate, hydrolyzed sclerotium gum, budding pullulan polysaccharide, tremella polysaccharide, sodium polyglutamate, PPG-10 methyl glucoside, panthenol and PPG-20 methyl glucoside; preferably at least one of glycerol, betaine, 1,3-propylene glycol, glyceryl glucoside, trehalose and sodium hyaluronate.

[0027] Furthermore, the anti-wrinkle agent includes at least one of collagen, retinol palmitate, acetyl hexapeptide-8 and silk core protein; preferably collagen.

[0028] Furthermore, the whitening agent includes at least one of niacinamide, glabridin, hexylresorcinol, phenethylresorcinol and tranexamic acid; niacinamide is preferred.

[0029] Furthermore, the allergy-relief agent includes at least one of dipotassium glycyrrhizinate, madecassoside, patchouli extract, glycyrrhetinic acid, gentian extract, iris extract and purslane extract; preferably dipotassium glycyrrhizinate.

[0030] Furthermore, the skin conditioning agent includes at least one of pearl extract, sialic acid, carnosine, hexapeptide-9 and ceramide; preferably carnosine.

[0031] Furthermore, the weight ratio of magnolia linalool, fibronectin, emollient, emulsifier, thickener, functional ingredient, preservative and pH adjuster in the instant redness-removing cosmetic composition is (0.001-1): (0.0001-1): (1-50): (0.1-10): (0.1-10): (0.1-50): (0.01-2): (0.01-3); In the selected instant redness-removing cosmetic composition, the weight percentages of magnoliavine, fibronectin, moisturizer, emulsifier, thickener, functional ingredient, preservative and pH adjuster are (0.001-1%): (0.0001-1%): (1-50%): (0.1-10%): (0.1-10%): (0.1-50%): (0.01-2%): (0.01-3%).

[0032] Furthermore, the weight ratio of magnolia renin, fibronectin, emollient, emulsifier, thickener, functional ingredient, preservative and pH adjuster in the instant redness-removing cosmetic composition is preferably (0.01-0.1): (0.001-0.1): (5-30): (0.2-5): (0.2-8): (0.1-20): (0.1-2): (0.05-2); in the optional instant redness-removing cosmetic composition of the present invention, the weight percentage of magnolia renin, fibronectin, emollient, emulsifier, thickener, functional ingredient, preservative and pH adjuster is (0.01-0.1%): (0.001-0.1%): (5-30%): (0.2-5%): (0.2-8%): (0.1-20%): (0.1-2%): (0.05-2%).

[0033] On the other hand, the present invention provides a method for preparing the above-mentioned instant redness-removing cosmetic composition, comprising the following steps:

[0034] (1) mixing a moisturizer, a thickener, a pH adjuster, and a preservative and heating the mixture to 75° C. to 85° C. to obtain a first mixed material;

[0035] (2) mixing the emollient and the emulsifier and heating the mixture to 75° C. to 85° C. to obtain a second mixed material;

[0036] (3) Then, the second mixed material is slowly pumped into the first mixed material, homogenized, stirred and mixed evenly, and then cooled to 35° C.-45° C.; then the instant redness removing composition is added, mixed evenly, and then cooled to room temperature;

[0037] When the instant redness-removing cosmetic composition contains an effective ingredient, the effective ingredient is added to the cooled mixed material in step (3).

[0038] It should be noted that the preparation method of the present invention is not limited to the order of preparing the first mixed material, the second mixed material and the instant redness-removing composition. When the instant redness-removing cosmetic composition contains an effective ingredient, the order of adding the effective ingredient to the cooled mixed material and the instant redness-removing composition in step (3) is not limited.

[0039] Optionally, after the second mixed material is pumped into the first mixed material, it is kept warm and stirred for a period of time and then cooled to improve the stability of the system. It should be noted that in the preparation method of the present invention, homogenization or stirring can be used to promote uniform mixing of materials or cooling of materials. For example, after the second mixed material is pumped into the first mixed material, a homogenization operation can be performed to promote material mixing, and stirring and cooling can be used to cool down, which does not limit the scope of protection of the present invention. It should be noted that the present invention does not limit the specific power and time of homogenization, as well as the specific operation mode of stirring, and those skilled in the art can choose according to their needs.

[0040] Compared with the prior art, the present invention has the following beneficial effects: compared with the use of magnolia alone or the combination of magnolia and a red-removing agent, the instant red-removing composition comprising magnolia and fibronectin of the present invention has high safety and can quickly alleviate and eliminate the phenomenon of skin redness. The instant red-removing cosmetic composition of the present invention has high stability, can solve the problem and demand of instant red-removing for different skins, and its preparation method is simple, highly operable, and has broad market prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] The drawings constituting a part of the present application are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the drawings:

[0042] Figure 1 The changes in skin redness before the skin tape was torn off, 10 minutes after the tape was torn off, and 50 minutes after the use of the cosmetic composition for instantly removing redness in Formulation Example 5 were shown. DETAILED DESCRIPTION

[0043] In order to facilitate the understanding of the present invention, the present invention will be described more comprehensively below, and preferred embodiments of the present invention are given. However, it should be understood that these embodiments are only used for more detailed description and should not be understood as limiting the present invention in any form, i.e., not intended to limit the scope of protection of the present invention.

[0044] Unless otherwise defined, the technical terms used in the following examples have the same meanings as those generally understood by those skilled in the art to which the present invention belongs. The test reagents used in the following examples, unless otherwise specified, are all conventional biochemical reagents; the experimental methods, unless otherwise specified, are all conventional methods.

[0045] Example 1

[0046] An instant redness-removing composition is prepared by adding magnolianoside and fibronectin into water at a mass ratio of 1:0.3 and stirring and mixing the mixture evenly, wherein the mass concentration of magnolianoside is 0.125% and the mass concentration of fibronectin is 0.0375%.

[0047] Example 2

[0048] An instant redness-removing composition is prepared by adding magnolia resin and fibronectin into 1,3-propylene glycol at a mass ratio of 1:0.6, and stirring and mixing the mixture evenly, wherein the mass concentration of magnolia resin is 0.25%, and the mass concentration of fibronectin is 0.15%.

[0049] Example 3

[0050] An instant redness-removing composition is prepared by adding magnolianoside and fibronectin into water at a mass ratio of 1:0.15 and stirring and mixing the mixture evenly, wherein the mass concentration of magnolianoside is 0.5% and the mass concentration of fibronectin is 0.075%.

[0051] Example 4

[0052] An instant redness-removing composition is prepared by adding magnolianoside and fibronectin into water at a mass ratio of 1:0.15 and stirring and mixing the mixture evenly, wherein the mass concentration of magnolianoside is 1% and the mass concentration of fibronectin is 0.15%.

[0053] Comparative Example 1

[0054] A redness-removing composition is prepared by adding magnolianoside and fibronectin into water at a mass ratio of 1:0.005 and stirring and mixing the mixture evenly, wherein the mass concentration of magnolianoside is 1% and the mass concentration of fibronectin is 0.005%.

[0055] Comparative Example 2

[0056] A redness-removing composition is prepared by adding magnolia resin and saffron extract into 1,3-propylene glycol at a mass ratio of 1:0.5, and stirring and mixing the mixture evenly, wherein the mass concentration of magnolia resin is 0.5%, and the mass concentration of saffron extract is 0.25%.

[0057] Comparative Example 3

[0058] A composition is obtained by adding synephrine and fibronectin into 1,3-propylene glycol at a mass ratio of 1:2 and stirring and mixing evenly, wherein the mass concentration of synephrine is 0.0187% and the mass concentration of fibronectin is 0.0375%.

[0059] Test Example 1

[0060] 2. TRPV1 expression test

[0061] This test example uses the instant redness-removing composition of Examples 1-4 and the redness-removing composition of Comparative Examples 1-3 to test the expression of TRPV1. Specifically: keratinocytes are inoculated into a 24-well plate at a seeding density of 1.8×105 cells / well and incubated overnight in an incubator (37°C, 5% CO2); when the cell plating rate in the 24-well plate reaches 40%-50%, group medication is performed, and the dosage per well is 1 mL, and 3 replicates are set for each group. After the administration is completed, the 24-well plate is placed in an incubator (37°C, 5% CO2) and incubated for 24 hours. After the incubation is completed, it is fixed with 4% paraformaldehyde. After fixation for 30 minutes, the immunofluorescence detection of TRPV1 is performed, and photos are taken under a microscope for observation, and pictures are collected and analyzed.

[0062] Data were statistically analyzed using GraphPad Prism, and the results were expressed as Mean ± SD. The t-test was used for statistical analysis between the groups. P < 0.05 was considered to be significantly different, and P < 0.01 was considered to be extremely significantly different. The results are shown in Table 2.

[0063] Table 2

[0064] Sample name concentration Inhibition rate % p-value CON / / / NC(Capsaicin) 15μM / / PC(trans-4-tert-butylcyclohexanol) 15.6 μg / mL 70.55 / Magnoliaceae 12.5ppm 22.97 / Synephrine 1.87ppm 47.83 / Fibronectin 3.75ppm 36.64 / Example 1 1％ 64.67 <0.05 Example 2 1％ 67.30 <0.05 Example 3 1％ 72.52 <0.05 Example 4 1％ 75.15 <0.05 Comparative Example 1 1％ 38.82 >0.05 Comparative Example 2 1％ 40.71 >0.05 Comparative Example 3 1％ 54.71 >0.05

[0065] It can be verified from the data in Table 2 that the instant redness-removing composition prepared by magnolia and fibronectin of the present invention has the effect of synergistically inhibiting the expression of TRPV1, which is significantly different from magnolia and fibronectin alone (p<0.05). However, the effect of the comparison ratio containing magnolia and redness-removing agent, or magnolia and redness-removing agent on TRPV1 expression is not better than magnolia alone, and the results are not significantly different (p>0.05).

[0066] Combined with Comparative Example 3, it was confirmed that the composition obtained by compounding fibronectin with other redness-removing agents was not as effective in inhibiting TRPV1 expression as fibronectin and magnolia oleracea, and experiments found that the stability of the cosmetic composition containing the composition of Comparative Example 3 was relatively poor.

[0067] In addition, in combination with the embodiment and comparative example 1, it can be confirmed that the addition amount of fibronectin relative to magnolia in the instant redness removing composition of the present invention affects the expression of TRPV1. Therefore, the weight ratio of the magnolia to the fibronectin in the instant redness removing composition of the present invention can be selected as 1:0.02-1.0, preferably 1:(0.15-0.6), and further preferably 1:0.15.

[0068] Example 5

[0069] This embodiment provides a cosmetic composition for instantly removing redness. The types and addition amounts of the components in the cosmetic composition for instantly removing redness are shown in Table 3.

[0070] Table 3

[0071]

[0072] The preparation method of the instant redness-removing cosmetic composition of this embodiment is as follows: (1) mixing phase A to obtain a first mixed material, and heating it to 80° C.; (2) mixing phase B to obtain a second mixed material, and heating it to 80° C.; (3) slowly pumping phase B into phase A, homogenizing (3000 rpm / min, 8 min), and stirring while keeping warm (30 rpm, 20 min); (4) stirring and cooling to 40° C., adding phase C, mixing evenly, and cooling to room temperature to obtain the cosmetic composition.

[0073] Test Example 2

[0074] 1. Stability test

[0075] This test example tests the stability of the instant redness-removing cosmetic combination of Example 5. Specifically, the stability tests of heat resistance, cold resistance, alternating, and light exposure were conducted; the heat resistance test conditions were: 45±1°C, constant temperature and light-proof, 7 days; the cold resistance test conditions were: 4±1°C, constant temperature and light-proof, 7 days; the alternating test conditions were: -18°C constant temperature and light-proof for 1 day to 25°C constant temperature and light-proof for 1 day, and 3 cycles of testing; the light exposure test conditions were: natural light exposure, 7 days. The test results are shown in Table 4.

[0076] Table 4

[0077] Sample name Heat resistant Cold resistant Alternation illumination Example 5 No abnormality No abnormality No abnormality No abnormality

[0078] It can be confirmed from Table 4 that the instant redness-removing cosmetic composition of the present invention has excellent stability.

[0079] 2. Human efficacy evaluation

[0080] The instant redness-removing cosmetic combination of Example 5 and the cosmetic composition of Comparative Example 7 were used to conduct human efficacy tests to evaluate whether they have the efficacy of instant redness-removing and skin-repairing. The specific evaluation process is as follows:

[0081] Subjects: A total of 5 subjects completed the assessment, ranging in age from 32 to 54 years old.

[0082] Test method: Select a 2cm×2cm area on the inner side of the forearm and use tape to tear and make a mold, and observe the improvement of redness before and after using the product.

[0083] Test cycle: after injury (D0), 10min, 30min, 50min after using the product.

[0084] Test equipment: C-cube is used for image acquisition and skin redness analysis.

[0085] Test steps: After the subject arrives, use a facial cleanser to clean the inside of the forearm and dry the skin with a dandruff-free dry facial tissue, and sit in a laboratory at a temperature of 23±1℃ and 50±10% RH for 10 minutes; the laboratory tester will perform 10 tape tearing injuries on the test area of ​​the subject, and then collect C-cube images of the test area, wait for 10 minutes before applying the product, wait for 10 minutes, 30 minutes, and 50 minutes, and then collect C-cube images again. Figure 1 The graph shows the changes in skin redness before the skin tape is torn off, 10 minutes after the tape is torn off and the product is used, and 50 minutes after the product is used when the instant redness-removing cosmetic composition prepared in Example 5 is applied to the subjects.

[0086] Data analysis: Excel was used to perform statistical analysis on the results, with a statistical significance level of p<0.05; the blank control was the result of not using the product. The a* values ​​of the skin red area are shown in Table 5.

[0087] Table 5

[0088]

[0089] Furthermore, the TEWL of Example 5 and Comparative Example 7 was tested using a Tewameter. The open skin TEWL meter is based on Fick's diffusion law to evaluate the skin barrier function. The larger the value, the more serious the damage to the skin barrier function; the smaller the value, the better the skin barrier function. The results are shown in Table 6.

[0090] Table 6

[0091]

[0092] Combining Table 5 and Table 6, the evaluation results of 5 subjects before and after continuous use of the product show that the instant redness-removing cosmetic composition of the present invention has the effects of instantly removing redness and repairing the skin barrier, and the effect is better than that of the blank control.

[0093] It should be noted that the above contents are further detailed descriptions of the present invention in combination with specific implementation methods, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, several simple improvements can be made without departing from the concept of the present invention, which should be regarded as falling within the scope of protection of the present invention.

Claims

1. An instant redness-removing composition, characterized in that: The instant redness-removing composition comprises magnoliavine and fibronectin.

2. The instant redness-removing composition according to claim 1, characterized in that: The weight ratio of the magnoliavine to the fibronectin is 1:0.02-1.0, preferably 1:0.15-0.

6.

3. Use of the instant redness-removing composition according to claim 1 or 2 in the preparation of cosmetics.

4. The use according to claim 3, characterized in that: The cosmetics are soothing cosmetics, cosmetics for repairing the skin after sun exposure, or cosmetics for repairing the skin after medical and cosmetic treatment; Preferably, the cosmetics include any one of water-based agents, emulsions, creams, facial masks, gels, and essences.

5. A cosmetic composition for instantly removing redness, characterized in that: The instant redness-removing composition comprises the instant redness-removing composition according to claim 1 or 2, a moisturizer, an emulsifier, a thickener, a preservative and a pH regulator, and the balance is water.

6. The instant redness-removing cosmetic composition according to claim 5, characterized in that: The emollients include triethylhexanoin, caprylic / capric triglyceride, isononyl isononanoate, dibutyl adipate, C12-15 alkyl benzoate, coconut oil-caprylate / caprate, propylheptyl caprylate, coconut oil glyceryl, isotridecyl isononanoate, squalane, triethylhexanoin, triisostearin, neopentyl glycol diheptanoate, isooctyl palmitate, isopropyl palmitate, propylene glycol dibenzoate, diheptyl succinate, shea butter, cetyl alcohol, dimethicone, cyclopentasiloxane, cyclohexasiloxane, phenethyl benzoate, pentaerythrityl tetraethylhexanoate, diisopropyl sebacate, olive oil, grape seed oil, white meadowfoam seed oil, avocado oil, corn oil, squalane, dicaprylyl carbonate, isopropyl myristate , hydrogenated polydecene, hydrogenated polyisobutene, sunflower seed oil, undecane, tridecane, isohexadecane, stearic acid, jojoba seed oil, lanolin, paraffin, microcrystalline wax and beeswax; preferably at least one of caprylic / capric triglyceride, isononyl isononanoate, dibutyl adipate, C12-15 alkyl benzoate, coconut oil alcohol-caprylate / caprate, propylheptyl caprylate, coconut oil glyceryl, squalane, isooctyl palmitate, isopropyl palmitate, avocado tree fruit butter, cetyl alcohol, dimethicone, cyclopentasiloxane, cyclohexasiloxane, hydrogenated polyisobutene, pentaerythrityl tetra(ethylhexanoate), olive oil, white meadowfoam seed oil, avocado oil, squalane, dicaprylyl carbonate, isopropyl myristate, sunflower seed oil, isohexadecane, and stearic acid; And / or, the emulsifier includes polyglyceryl-6 stearate, polyglyceryl-6 behenate, PEG-100 stearate, glyceryl stearate, cetearyl olive oil ester, sorbitan olive oil ester, sorbitan oleate, glyceryl stearate citrate, potassium cetyl phosphate, sodium stearoyl glutamate, cetearyl glucoside, C12-20 alkyl glucoside, steareth-2, steareth-21, sorbitan stearate, polysorbate-20, polysorbate-60, polysorbate-80, trideceth-6, PEG-60 hydrogenated castor oil, PEG-9 polydimethylsiloxyethyl polydimethicone, sorbitan olive oil ester, PPG-13-decyltetradecyl alcohol polyether-24, sorbitan monoisostearate, C10-C22 At least one of fatty acids, monoglyceryl citrate, glyceryl stearate, glyceryl stearate SE, glyceryl stearate citrate, isostearyl glyceryl ether, potassium cetyl phosphate, lecithin, methyl glucose sesquistearate, lactic acid monoglyceride, acetate monoglyceride, citric acid monoglyceride, diacetyl tartaric acid monoglyceride, lactic acid monoglyceride, tartaric acid monoglyceride, Na salt of lauryl sulfate, and sodium cetyl phosphate; preferably at least one of polyglyceryl-6 stearate, polyglyceryl-6 behenate, PEG-100 stearate, glyceryl stearate, cetearyl olive oil ester, sorbitan olive oil ester, sorbitan oleate, lecithin, cetearyl glucoside, C12-20 alkyl glucoside, sorbitan stearate, glyceryl stearate, and glyceryl stearate SE; And / or, the thickener includes at least one of carbomer, xanthan gum, hydroxyethyl cellulose, hydroxypropyl cellulose, sphingomonas fermentation product extract, acrylic acid (ester) / C10 30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer, sodium polyacryloyldimethyl taurate, sodium polyacrylate grafted starch, dextrin palmitate, gum arabic, disteardimonium hectorite, polyethylene glycol 14M, polyethylene glycol 90M and succinoglycan; preferably at least one of carbomer, xanthan gum, hydroxyethyl cellulose, sphingomonas fermentation product extract, acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, ammonium acryloyldimethyl taurate / behenyl alcohol polyether-25 methacrylate crosspolymer; And / or, the preservative includes at least one of phenoxyethanol, benzyl alcohol, phenylethyl alcohol, potassium sorbate, sodium benzoate, chlorphenesin, 1,2-hexanediol, caprylyl glycol and p-hydroxyacetophenone; preferably p-hydroxyacetophenone and 1,2-hexanediol; And / or, the pH regulator includes at least one of triethanolamine, arginine, sodium hydroxide, potassium hydroxide, tromethamine, disodium EDTA, citric acid and sodium citrate; preferably disodium EDTA.

7. The instant redness-removing cosmetic composition according to claim 5 or 6, characterized in that: The weight ratio of magnolia linalool, fibronectin, emollient, emulsifier, thickener, preservative and pH adjuster in the instant redness-removing cosmetic composition is (0.001-1): (0.0001-1): (1-50): (0.1-10): (0.1-10): (0.01-2): (0.01~3), preferably (0.01~0.1): (0.001~0.1): (5~30): (0.2~5): (0.2~8): (0.1～2)：(0.05～2)。 8. The instant redness-removing cosmetic composition according to claim 5, characterized in that: The instant redness-removing cosmetic composition further comprises an effective ingredient; the effective ingredient comprises at least one of an antioxidant, a moisturizer, an anti-wrinkle agent, a whitening agent, a soothing agent, and a skin conditioning agent; Preferably, the oxidant comprises at least one of ascorbic acid, ubiquinone, ergothioneine and idebenone; preferably ergothioneine; Preferably, the moisturizing agent includes at least one of glycerol, dipropylene glycol, 1,3-butylene glycol, 1,3-propylene glycol, propylene glycol, 1,2-pentanediol, betaine, glyceryl glucoside, methyl gluceth 20, glyceryl glucoside 26, trehalose, sucrose, mannitol, rhamnose, xylitol, hyaluronic acid, sodium hyaluronate, polyethylene glycol-8, methyl gluceth-10, PEG / PPG-17 / 6 copolymer, sodium polyglutamate, hydrolyzed sclerotium gum, budding pullulan polysaccharide, tremella polysaccharide, sodium polyglutamate, PPG-10 methyl glucoside, panthenol and PPG-20 methyl glucoside; preferably at least one of glycerol, betaine, 1,3-propylene glycol, glyceryl glucoside, trehalose and sodium hyaluronate; Preferably, the anti-wrinkle agent comprises at least one of collagen, retinol palmitate, acetyl hexapeptide-8 and silk core protein; preferably collagen; Preferably, the whitening agent comprises at least one of niacinamide, glabridin, hexylresorcinol, phenethylresorcinol and tranexamic acid; preferably niacinamide; Preferably, the allergy-relief agent comprises at least one of dipotassium glycyrrhizinate, madecassoside, patchouli extract, glycyrrhetinic acid, gentian extract, iris extract and purslane extract; preferably dipotassium glycyrrhizinate; Preferably, the skin conditioning agent comprises at least one of pearl extract, sialic acid, carnosine, hexapeptide-9 and ceramide; preferably carnosine.

9. The instant redness-removing cosmetic composition according to any one of claim 8, characterized in that: The weight ratio of magnolia linalool, fibronectin, emollient, emulsifier, thickener, functional ingredient, preservative and pH adjuster in the instant redness-removing cosmetic composition is (0.001-1): (0.0001-1): (1-50): (0.1-10): (0.1-10): (0.1~50):(0.01~2):(0.01~3), preferably (0.01~0.1):(0.001~0.1):(5~30): (0.2～5)：(0.2～8)：(0.1～20)：(0.1～2)：(0.05～2)。 10. A method for preparing the instant redness-removing cosmetic composition according to any one of claims 5 to 9, characterized in that: The following steps are involved: (1) mixing a moisturizer, a thickener, a pH adjuster, and a preservative and heating the mixture to 75° C. to 85° C. to obtain a first mixed material; (2) mixing the emollient and the emulsifier and heating the mixture to 75° C. to 85° C. to obtain a second mixed material; (3) Then, the second mixed material is slowly pumped into the first mixed material, homogenized, stirred and mixed evenly, and then cooled to 35° C.-45° C.; then the instant redness removing composition is added, mixed evenly, and then cooled to room temperature; When the instant redness-removing cosmetic composition contains an effective ingredient, the effective ingredient is added to the cooled mixed material in step (3).

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