Method for extracting and purifying ursocholic acid from bear gall powder

Abstract

The invention discloses a method for extracting and purifying ursocholic acid from bear gall powder, and relates to the technical field of traditional Chinese medicine preparation.A rack is included, a reaction mechanism is arranged on the rack, a purification mechanism is arranged under the reaction mechanism, and an adaptive opening and closing mechanism is arranged between the reaction mechanism and the purification mechanism; bear gall powder raw materials and purified water are injected through an injection pipe at the top end of the reaction mechanism, and the driving mechanism drives a main shaft power piece and an external load rotating assembly of the stirring and pressing mechanism to mix mixed feed liquid, so that the bear gall powder raw materials are fully dissolved, and the dissolving time is shortened; the state of the main shaft power part, the state of the outer load rotating assembly and the state of the inner rotating assembly are adjusted through the adjusting assembly, meanwhile, the adaptive opening and closing mechanism is started, the dissolved material liquid is flushed into the purification mechanism to be purified, and the purification process is further shortened through the rotating pressurization state. The purification efficiency is higher, and a new process of extracting ursocholic acid is facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and more specifically to a method for extracting and purifying total bile acid from bear bile powder. Background Art

[0002] Bear bile powder is a powdered substance made from the dried bile of brown bears or black bears. It is widely used in traditional medicine. As a Chinese patent medicine, bear bile powder has the effects of clearing away heat, calming the liver, and improving eyesight. It is often used clinically to treat symptoms such as convulsions, red and swollen eyes, and sore throat. In addition, bear bile powder can also be used externally to treat sores, carbuncles, hemorrhoids and other diseases.

[0003] The components with higher content in bear bile powder include ursodeoxycholic acid and chenodeoxycholic acid. Ursodeoxycholic acid is an organic compound, odorless and bitter. It is used in medicine to increase bile acid secretion, change the composition of bile, reduce cholesterol and cholesterol esters in bile, and help the cholesterol in gallstones to gradually dissolve.

[0004] Although bear bile powder contains a variety of pharmacologically active ingredients, total ursocholic acid (mainly including ursodeoxycholic acid and ursocholic acid, etc.) is its main active ingredient. Bear bile powder also contains impurities such as protein, fat, amino acids, sugars, some pigments, inorganic salts, etc., which may reduce the effect of total ursocholic acid. Therefore, by extracting and purifying total ursocholic acid, the effectiveness and purity of the drug can be significantly improved, and the interference of ineffective ingredients and impurities on the drug effect can be reduced. At the same time, when the purified total ursocholic acid is used in preparations such as injections, it can reduce the occurrence of adverse reactions such as hemolysis and improve the safety of the drug.

[0005] Traditional extraction and purification methods, such as alkaline hydrolysis, acidification, extraction, concentration and crystallization, can achieve the extraction of total bile acid to a certain extent, but due to the many steps and the long reaction time of hydrolysis and filtration, the efficiency of the entire extraction and purification process is low, and it is difficult to completely remove impurities, resulting in low purity of the final product, affecting its medicinal value and market prospects. In view of this, we propose a method for extracting and purifying total bile acid from bear bile powder. Summary of the invention

[0006] The purpose of the present invention is to provide a method for extracting and purifying total bile acid from bear bile powder, so as to solve the technical problem that the existing method for extracting total bile acid from bear bile is inefficient.

[0007] In order to solve the above technical problems, the present invention provides the following technical solutions: a method for extracting and purifying total bile acid from bear bile powder, the method is implemented based on a purification device, the device is characterized in that it comprises a frame, a reaction mechanism is arranged on the frame, a purification mechanism is arranged at a position directly below the reaction mechanism, an adaptive opening and closing mechanism is arranged between the reaction mechanism and the purification mechanism, an injection pipe is arranged on the outer wall of the top of the reaction mechanism, a bearing mounting frame is arranged at the top of the reaction mechanism, a driving mechanism is arranged on the bearing mounting frame, and a stirring and pressing mechanism is hoisted on the bearing mounting frame at a position directly above the reaction mechanism; The stirring and pressing mechanism comprises an adjusting component, a main shaft power member, an external load-carrying rotating component and an internal rotation component, wherein the main shaft power member is connected to the output end of the driving mechanism and is located directly below the carrying mounting frame, one end of the adjusting component is connected to the driving mechanism, and the other end of the adjusting component is movably sleeved on the main shaft power member, the external load-carrying rotating component is rotatably sleeved on the main shaft power member, the adjusting component is also movably inserted on the external load-carrying rotating component, and the internal rotation component is movably arranged at the bottom end of the external load-carrying rotating component in an annular and equidistant manner and located between the main shaft power member and the external load-carrying rotating component; The driving mechanism drives the adjusting component so that the main shaft power part, the external rotating component and the internal rotating component form a mixing and stirring state or a rotating and pressurizing state.

[0008] Preferably, the main shaft power component includes a transmission main shaft, a power disc, a locking slot, an outer ring tooth groove, a stirring shaft and inner blades. The transmission main shaft is connected to the output end of the driving mechanism and is located directly below the supporting mounting frame. The power disc is fixedly connected to the bottom end of the transmission main shaft. The locking slot is opened at the top of the power disc. The outer ring tooth groove is opened on the outer wall of the power disc. The stirring shaft is connected to the bottom end of the power disc. The inner blades are connected to the outer wall of the transmission main shaft in a ring-shaped and equidistant manner. The locking slot is adapted to the adjusting component, and the outer ring tooth groove is adapted to the inner rotating component.

[0009] Preferably, the adjustment assembly includes a sliding plate, a locking block, a fixing rod and a fixing ring, the sliding plate is movably mounted on the transmission main shaft, the locking block is movably mounted on the transmission main shaft at a position directly below the sliding plate, the sliding plate and the locking block are fixedly connected via the fixing rod, the fixing ring is fixedly mounted on the outer wall of the sliding plate, and the fixing ring is connected to the output end of the driving mechanism at one end away from the sliding plate.

[0010] Preferably, the external load rotation assembly comprises a rotating disk, a connecting frame, an outer ring frame, a top ring plate, an inner ring tooth groove, an annular sliding groove and an outer paddle member, the rotating disk is rotatably sleeved on the transmission main shaft, the connecting frame is fixedly connected to the outer wall of the rotating disk in an annular shape with equal intervals, the outer ring frame is fixedly connected to the end of the connecting frame away from the rotating disk, the top ring plate is fixedly arranged on the top end of the inner wall of the outer ring frame, the annular sliding groove is arranged at the bottom end of the top ring plate, the inner ring tooth groove is arranged at the bottom end of the inner wall of the outer ring frame, the inner ring tooth groove and the annular sliding groove are adapted to the inner rotating assembly, and the outer paddle member is fixedly connected to the bottom end of the outer ring frame in an annular shape with equal intervals; The outer paddle member includes a connecting rod and an outer paddle blade. The connecting rod is fixedly connected to the bottom end of the outer ring frame in an annular shape with equal intervals. The outer paddle blade is fixedly connected to the bottom end of the connecting rod, and the outer paddle blade is adapted to the inner paddle blade.

[0011] Preferably, the inner rotating component includes a sliding rod and a first gear, the sliding rod is movably inserted in the annular groove in a ring shape with equal intervals, the first gear is connected to the bottom end of the sliding rod, one end of the first gear is meshed and connected to the outer ring tooth groove, and the other end of the first gear is meshed and connected to the inner ring tooth groove.

[0012] Preferably, the reaction mechanism comprises a reaction tank, a reaction chamber and an output hole, the reaction tank is arranged on the frame, the reaction chamber is opened inside the reaction tank, the output hole is opened at the bottom of the reaction tank, the reaction chamber is connected with the output hole, and the output hole is connected with the adaptive opening and closing mechanism.

[0013] Preferably, the purification mechanism includes a purification outer cylinder, an attached filter cartridge and a drain valve, the purification outer cylinder is connected to the frame at a position directly below the reaction mechanism, the attached filter cartridge is arranged inside the purification outer cylinder, the drain valve is arranged at the bottom end of the purification outer cylinder, and the output hole is connected to the purification outer cylinder.

[0014] Preferably, the adaptive opening and closing mechanism includes a fixed top ring, a first long hole, a sliding rod, a moving block, a rotating bottom ring, a second long hole, an external tooth groove, a servo motor and a second gear. The fixed top ring is fixedly connected to the bottom end of the reaction mechanism, the first long hole is arranged in a ring shape with equal intervals on the fixed top ring, the rotating bottom ring is rotatably connected to the top of the purification mechanism, the second long hole is arranged in a ring shape with equal intervals on the rotating bottom ring, one end of the sliding rod is movably inserted in the first long hole, and the other end of the sliding rod is movably inserted in the second long hole, the moving block is sleeved on the sliding rod, the external tooth groove is arranged on the outer wall of the rotating bottom ring, the servo motor is arranged on the frame, one end of the second gear is connected to the output end of the servo motor, and the other end of the second gear is meshedly connected to the external tooth groove.

[0015] Preferably, the driving mechanism includes a reduction motor and a cylinder, the reduction motor is arranged on the bearing mounting frame at a position directly above the transmission main shaft, the transmission main shaft is connected to the output end of the reduction motor, the cylinder is arranged on the bearing mounting frame, and the end of the fixing ring away from the sliding plate is connected to the output end of the cylinder.

[0016] Preferably, the present invention also provides a method comprising the following steps: S1, raw material conveying operation; Firstly, bear bile powder and purified water are injected into the reaction chamber of the reaction tank through the injection tube; S2, state adjustment operation; Select the specific adjustment mode according to the required mixing state or rotating pressurization state; S2.1. If a mixing and dissolving operation is required, the fixed ring is driven upward by the return stroke of the cylinder. The fixed sleeve of the fixed ring is arranged on the sliding plate, driving the sliding plate to move synchronously. The sliding plate is fixedly connected to the locking block by the fixing rod. Therefore, when the return stroke of the cylinder drives the fixed ring to move upward, the sliding plate, the fixing rod and the locking block are synchronously driven to slide on the transmission main shaft, and the locking block is disengaged from the locking slot of the power disc. The driving mechanism drives the transmission main shaft to rotate, and the transmission main shaft drives the power disc, the locking slot, the outer ring tooth groove, the stirring shaft and the inner blade to rotate synchronously, and the outer ring tooth groove is meshed with the first gear. The first gear is driven to rotate on the ring slide groove, and the other side of the first gear is meshed with the inner ring tooth groove to drive the outer ring frame to rotate, the outer ring frame drives the connecting rod, and the connecting rod drives the outer blade to rotate. Since the radius of the power disc is smaller than the radius of the outer ring frame, there is a speed difference between the power disc and the outer ring frame, so that the rotation of the inner blade and the outer blade also produces a speed difference, so that in the process of mixing and stirring the bear bile powder and purified water for dissolution, the speed difference generated between the inner blade and the outer blade offsets part of the centrifugal force generated by the stirring rotation, so that the bear bile powder and purified water can be dissolved more fully; S2.2. If a rotary boost operation is required, the cylinder stroke drives the fixed ring to move downward, and the fixed ring is fixedly mounted on the sliding plate, driving the sliding plate to move synchronously. The sliding plate is fixedly connected to the locking block through a fixed rod. Therefore, when the cylinder stroke drives the fixed ring to move downward, the sliding plate, the fixed rod and the locking block are synchronously driven to slide on the transmission main shaft, and the locking block is inserted into the locking slot of the power disc. At this time, the driving mechanism drives the transmission main shaft to rotate, and the transmission main shaft drives the power disc, the locking slot, the outer ring tooth groove, the stirring shaft and the inner blade to rotate synchronously. The locking block is inserted in the locking slot. At this time, the power disc and the locking slot rotate synchronously to drive the locking block and the fixed rod to rotate. The fixed rod is inserted in the rotating disc to drive the rotating disc to rotate synchronously. The rotating disc drives the connecting frame, the outer ring frame, the connecting rod and the outer blade to rotate synchronously. At this time, the power disc and the outer ring frame rotate at the same speed. Therefore, the outer blade and the inner blade rotate as a whole at the same speed. The outer blade and the inner blade are spliced ​​into a shape similar to a negative pressure blade. After the opening and closing mechanism is adapted to be opened, the mixed liquid is evenly pressed into the purification mechanism for filtration. S3, adaptive opening and closing operation; The driving servo motor drives the second gear to rotate, the meshing of the second gear drives the external tooth groove to rotate, the external tooth groove drives the rotating bottom ring to rotate, the rotating bottom ring drives the second long hole to rotate, the rotation of the second long hole causes the slide bar to slide in the second long hole and the first long hole, so that the position of the slide bar moves, and the slide bar drives the moving block to move synchronously to achieve the opening and closing effect. When the stirring and pressing mechanism is in the mixing and stirring state, the opening and closing mechanism is adapted to be in the closed state, and when the stirring and pressing mechanism is in the rotating and pressurizing state, the opening and closing mechanism is adapted to be in the open state; S4, purification operation; When the mixed liquid enters the purification outer cylinder through the adaptive opening and closing mechanism, the impurities such as protein, fat, amino acid, sugar, some pigments and inorganic salts are filtered out by the attached filter cartridge, and the liquid with higher purity of total bile acid is obtained by opening the discharge valve.

[0017] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention arranges a reaction mechanism on a frame, arranges a purification mechanism directly below the reaction mechanism, arranges an adaptive opening and closing mechanism between the reaction mechanism and the purification mechanism, injects bear bile powder raw material and purified water through an injection pipe at the top of the reaction mechanism, drives the main shaft power parts and the external load rotating assembly of the stirring and pressing mechanism by a driving mechanism to mix the mixed liquid, so that the bear bile powder raw material is fully dissolved and its dissolution time is shortened, and adjusts the states of the main shaft power parts, the external load rotating assembly and the internal rotating assembly through an adjusting assembly, and at the same time opens the adaptive opening and closing mechanism, so that the dissolved liquid rushes into the purification mechanism for purification, and the purification process is further shortened by the rotation and pressurization state. The stirring and pressing mechanism of the present invention has a shorter purification and stripping time and a higher purification efficiency, which is beneficial to the new process of total bile acid extraction of bears.

[0018] 2. The rotating disk of the present invention is rotatably sleeved on the transmission main shaft. When the locking block of the adjusting component is not inserted into the locking slot of the power disc, the driving mechanism drives the transmission main shaft to rotate, and the transmission main shaft drives the power disc, the locking slot, the outer ring tooth groove, the stirring shaft and the inner paddle to rotate synchronously. The outer ring tooth groove is meshed with the first gear to drive the first gear to rotate on the ring groove. The other side of the first gear is meshed with the inner ring tooth groove to drive the outer ring frame to rotate, the outer ring frame drives the connecting rod, and the connecting rod drives the outer paddle to rotate. Since the radius of the power disc is smaller than the radius of the outer ring frame, there is a speed difference between the power disc and the outer ring frame at this time, so that the rotation of the inner paddle and the outer paddle also produces a speed difference, so that in the process of mixing and stirring the bear bile powder and purified water for dissolution, the speed difference generated between the inner paddle and the outer paddle offsets part of the centrifugal force generated by the stirring rotation, so that the bear bile powder and purified water can be more fully dissolved, further improving the dissolution efficiency, and facilitating the subsequent uniform pressing into the purification mechanism, further shortening the extraction time.

[0019] 3. The present invention also drives the fixed ring to move through the driving mechanism, and the fixed ring is fixedly sleeved on the sliding plate, driving the sliding plate to move synchronously. The sliding plate is fixedly connected to the locking block through the fixing rod. Therefore, when the driving mechanism drives the fixed ring to move, the sliding plate, the fixing rod and the locking block are synchronously driven to slide on the transmission main shaft, and the locking block is inserted into the locking slot of the power disc. At this time, the driving mechanism drives the transmission main shaft to rotate, and the transmission main shaft drives the power disc, the locking slot, the outer ring tooth groove, the stirring shaft and the inner blade to rotate synchronously. Since the locking block is inserted in the lock On the stop slot, at this time, the power disc and the locking slot rotate synchronously, driving the locking block and the fixed rod to rotate, and the fixed rod is inserted on the rotating disk, driving the rotating disk to rotate synchronously, and the rotating disk drives the connecting frame, the outer ring frame, the connecting rod and the outer blade to rotate synchronously. At this time, the power disc and the outer ring frame rotate at the same speed, so the outer blade and the inner blade rotate as a whole at the same speed. The outer blade and the inner blade are spliced ​​into a negative pressure blade-like shape. After the opening and closing mechanism is opened, the mixed liquid is evenly pressed into the purification mechanism for filtration, thereby further improving the purification efficiency.

[0020] 4. In the present invention, the second gear is driven to rotate by driving the servo motor, the second gear meshing drives the outer tooth groove to rotate, the outer tooth groove drives the rotating bottom ring to rotate, the rotating bottom ring drives the second long hole to rotate, the second long hole rotates to make the slide bar slide in the second long hole and the first long hole, so that the position of the slide bar moves, and the slide bar drives the moving block to move synchronously to achieve the opening and closing effect. When the stirring and pressing mechanism is in the mixing and stirring state, the adaptive opening and closing mechanism is in the closed state; when the stirring and pressing mechanism is in the rotating and pressurizing state, the adaptive opening and closing mechanism is in the open state. The adaptive opening and closing mechanism of the present invention can adaptively adjust the size of the flow hole according to the filter flow of the purification mechanism, and cooperate with the rotating and pressurizing state of the stirring and pressing mechanism to adjust the pressure of the mixed liquid entering the purification mechanism, thereby achieving more precise control, which is beneficial to further improve the extraction quality and efficiency of total bile acid. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the other side of the whole and the internal structure of the reaction mechanism of the present invention; Figure 3 It is a cross-sectional view of the reaction mechanism, the adaptive opening and closing mechanism, the driving mechanism and the stirring and pressing mechanism of the present invention; Figure 4 It is a schematic diagram of the cross-sectional view of the reaction mechanism, the driving mechanism and the stirring and pressing mechanism of the present invention; Figure 5 It is a schematic structural diagram of the reaction mechanism cross-section, the adaptive opening and closing mechanism cross-section and the purification mechanism cross-section of the present invention; Figure 6 It is a schematic diagram of the split structure of the adaptive opening and closing mechanism and the purification mechanism of the present invention; Figure 7 It is a schematic diagram of the split structure of the adaptive opening and closing mechanism of the present invention; Figure 8 It is a cross-sectional view of the reaction mechanism, the driving mechanism and the stirring and pressing mechanism of the present invention; Fig. 9 It is a schematic diagram of the top surface structure of the stirring and pressing mechanism of the present invention; Fig.10 It is a schematic diagram of the bottom structure of the stirring and pressing mechanism of the present invention; Fig.11 It is a schematic diagram of the split structure of the stirring and pressing mechanism of the present invention; Fig.12 It is a schematic diagram of the side view of the driving mechanism, the adjusting assembly and the main shaft power part of the present invention; Fig.13 This is a schematic diagram of the mixing and stirring use state of the present invention; Fig.14 It is a schematic diagram of the rotary supercharging in use of the present invention.

[0022] Description of the numbers in the figure: 1. Frame; 2. Reaction mechanism; 3. Purification mechanism; 4. Adaptive opening and closing mechanism; 5. Injection pipe; 6. Load-bearing mounting frame; 7. Driving mechanism; 8. Stirring and pressing mechanism; 201, reaction tank; 202, reaction chamber; 203, output hole; 301, purification outer cylinder; 302, attached filter cartridge; 303, drain valve; 401, fixed top ring; 402, first long hole; 403, slide bar; 404, moving block; 405, rotating bottom ring; 406, second long hole; 407, external tooth groove; 408, servo motor; 409, second gear; 701, reduction motor; 702, cylinder; 801, adjustment assembly; 802, spindle power component; 803, external load rotation assembly; 804, internal rotation assembly; 8011, sliding plate; 8012, locking block; 8013, fixing rod; 8014, fixing ring; 8021, transmission main shaft; 8022, power disc; 8023, locking slot; 8024, outer ring tooth groove; 8025, stirring shaft; 8026, inner blade; 8031, rotating plate; 8032, connecting frame; 8033, outer ring frame; 8034, top ring plate; 8035, inner ring tooth groove; 8036, ring slide groove; 8037, outer paddle member; 8038, connecting rod; 8039, outer paddle blade; 8041, a sliding rod; 8042, a first gear. DETAILED DESCRIPTION

[0023] like Figures 1 to 14 As shown, the present invention relates to a device for extracting and purifying total bile acid from bear bile powder, characterized in that it comprises a frame 1, a reaction mechanism 2 is arranged on the frame 1, a purification mechanism 3 is arranged on the frame 1 directly below the reaction mechanism 2, an adaptive opening and closing mechanism 4 is arranged between the reaction mechanism 2 and the purification mechanism 3, an injection pipe 5 is arranged on the outer wall of the top end of the reaction mechanism 2, a bearing mounting frame 6 is arranged on the top end of the reaction mechanism 2, a driving mechanism 7 is arranged on the bearing mounting frame 6, and a stirring and pressing mechanism 8 is hoisted on the bearing mounting frame 6 directly above the reaction mechanism 2; The stirring and pressing mechanism 8 includes an adjusting component 801, a main shaft power member 802, an external load-carrying rotating component 803 and an internal rotation component 804. The main shaft power member 802 is connected to the output end of the driving mechanism 7 and is located directly below the load-carrying mounting frame 6. One end of the adjusting component 801 is connected to the driving mechanism 7, and the other end of the adjusting component 801 is movably sleeved on the main shaft power member 802. The external load-carrying rotating component 803 is rotatably sleeved on the main shaft power member 802. The adjusting component 801 is also movably inserted on the external load-carrying rotating component 803. The internal rotation component 804 is movably arranged at the bottom end of the external load-carrying rotating component 803 in a circular shape with equal spacing, and is located between the main shaft power member 802 and the external load-carrying rotating component 803. The driving mechanism 7 drives the adjusting component 801 to cause the main shaft power component 802, the external rotating component 803 and the internal rotating component 804 to form a mixing and stirring state or a rotating and pressurizing state.

[0024] The present invention arranges a reaction mechanism 2 on a frame 1, arranges a purification mechanism 3 directly below the reaction mechanism 2, arranges an adaptive opening and closing mechanism 4 between the reaction mechanism 2 and the purification mechanism 3, injects bear bile powder raw material and purified water through an injection pipe 5 at the top of the reaction mechanism 2, drives the main shaft power part 802 and the external load rotation component 803 of the stirring and pressing mechanism 8 through a driving mechanism 7 to mix the mixed liquid, so that the bear bile powder raw material is fully dissolved and its dissolution time is shortened, and adjusts the states of the main shaft power part 802, the external load rotation component 803 and the internal rotation component 804 through an adjusting component 801, and at the same time opens the adaptive opening and closing mechanism 4, so that the dissolved liquid rushes into the purification mechanism 3 for purification, and the purification process is further shortened by the rotation and pressurization state. The stirring and pressing mechanism 8 of the present invention has a shorter purification and stripping time and a higher purification efficiency, which is beneficial to the new process of extracting total bile acid of bears.

[0025] In an embodiment of the present invention, the main shaft power component 802 includes a transmission main shaft 8021, a power disc 8022, a locking slot 8023, an outer ring tooth groove 8024, a stirring shaft 8025 and an inner paddle 8026. The transmission main shaft 8021 is connected to the output end of the driving mechanism 7 and is located directly below the load-bearing mounting frame 6. The power disc 8022 is fixedly connected to the bottom end of the transmission main shaft 8021. The locking slot 8023 is opened at the top of the power disc 8022. The outer ring tooth groove 8024 is opened on the outer wall of the power disc 8022. The stirring shaft 8025 is connected to the bottom end of the power disc 8022. The inner paddle 8026 is connected to the outer wall of the transmission main shaft 8021 in a ring-shaped and equidistant manner. The locking slot 8023 is adapted to the adjustment component 801, and the outer ring tooth groove 8024 is adapted to the inner rotation component 804. In the present invention, the transmission main shaft 8021 is driven to rotate by the driving mechanism 7, and the transmission main shaft 8021 drives the power disc 8022, the locking slot 8023, the outer ring tooth groove 8024, the stirring shaft 8025 and the inner blade 8026 to rotate synchronously.

[0026] The adjustment component 801 includes a sliding plate 8011, a locking block 8012, a fixing rod 8013 and a fixing ring 8014. The sliding plate 8011 is movably mounted on the transmission main shaft 8021. The locking block 8012 is movably mounted on the transmission main shaft 8021 at a position directly below the sliding plate 8011. The sliding plate 8011 and the locking block 8012 are fixedly connected by the fixing rod 8013. The fixing ring 8014 is fixedly mounted on the outer wall of the sliding plate 8011. The end of the fixing ring 8014 away from the sliding plate 8011 is connected to the output end of the driving mechanism 7. In the present invention, the fixed ring 8014 is driven to move by the driving mechanism 7. The fixed ring 8014 is fixedly sleeved on the sliding plate 8011, driving the sliding plate 8011 to move synchronously. The sliding plate 8011 is fixedly connected to the locking block 8012 through the fixing rod 8013. Therefore, when the driving mechanism 7 drives the fixed ring 8014 to move, the sliding plate 8011, the fixing rod 8013 and the locking block 8012 are synchronously driven to slide on the transmission main shaft 8021.

[0027] The external load-carrying rotating assembly 803 comprises a rotating disk 8031, a connecting frame 8032, an outer ring frame 8033, a top ring plate 8034, an inner ring tooth groove 8035, an annular sliding groove 8036 and an outer paddle member 8037. The rotating disk 8031 ​​is rotatably sleeved on the transmission main shaft 8021. The connecting frame 8032 is fixedly connected to the outer wall of the rotating disk 8031 ​​in an annular shape with equal intervals. The outer ring frame 8033 is fixedly connected to the end of the connecting frame 8032 away from the rotating disk 8031. The top ring plate 8034 is fixedly arranged on the top of the inner wall of the outer ring frame 8033. The annular sliding groove 8036 is provided at the bottom end of the top ring plate 8034. The inner ring tooth groove 8035 is provided at the bottom end of the inner wall of the outer ring frame 8033. The inner ring tooth groove 8035 and the annular sliding groove 8036 are adapted to the internal rotating assembly 804. The outer paddle member 8037 is fixedly connected to the bottom end of the outer ring frame 8033 in an annular shape with equal intervals. The outer paddle component 8037 includes a connecting rod 8038 and an outer paddle blade 8039. The connecting rod 8038 is fixedly connected to the bottom end of the outer ring frame 8033 in a ring shape with equal intervals. The outer paddle blade 8039 is fixedly connected to the bottom end of the connecting rod 8038, and the outer paddle blade 8039 is adapted to the inner paddle blade 8026.

[0028] The inner rotating component 804 includes a sliding rod 8041 and a first gear 8042. The sliding rod 8041 is movably inserted in the annular groove 8036 in a ring shape with equal intervals. The first gear 8042 is connected to the bottom end of the sliding rod 8041. One end of the first gear 8042 is meshedly connected to the outer ring groove 8024, and the other end of the first gear 8042 is meshedly connected to the inner ring groove 8035.

[0029] The rotating disk 8031 ​​of the present invention is rotatably sleeved on the transmission main shaft 8021. When the locking block 8012 of the adjustment component 801 is not inserted into the locking slot 8023 of the power disc 8022, the driving mechanism 7 drives the transmission main shaft 8021 to rotate, and the transmission main shaft 8021 drives the power disc 8022, the locking slot 8023, the outer ring tooth groove 8024, the stirring shaft 8025 and the inner blade 8026 to rotate synchronously. The outer ring tooth groove 8024 meshes with the first gear 8042 to drive the first gear The wheel 8042 rotates on the ring groove 8036, and the other side of the first gear 8042 meshes with the inner ring tooth groove 8035 to drive the outer ring frame 8033 to rotate, and the outer ring frame 8033 drives the connecting rod 8038, and the connecting rod 8038 drives the outer blade 8039 to rotate. Since the radius of the power disc 8022 is smaller than the radius of the outer ring frame 8033, there is a speed difference between the power disc 8022 and the outer ring frame 8033, so that the rotation of the inner blade 8026 and the outer blade 8039 also produces a speed difference, such as Fig.13 As shown, during the process of mixing and stirring the bear bile powder and purified water for dissolution, the speed difference between the inner blade 8026 and the outer blade 8039 offsets part of the centrifugal force generated by the stirring rotation, so that the bear bile powder and purified water can be dissolved more fully, further improving the dissolution efficiency, and facilitating the subsequent uniform pressing into the purification mechanism 3, further shortening the extraction time.

[0030] The present invention also drives the fixed ring 8014 to move through the driving mechanism 7. The fixed ring 8014 is fixedly sleeved on the sliding plate 8011, driving the sliding plate 8011 to move synchronously. The sliding plate 8011 is fixedly connected to the locking block 8012 through the fixing rod 8013. Therefore, when the driving mechanism 7 drives the fixed ring 8014 to move, the sliding plate 8011, the fixing rod 8013 and the locking block 8012 are synchronously driven to slide on the transmission main shaft 8021, and the locking block 8012 is inserted into the locking slot 8023 of the power disc 8022. At this time, the driving mechanism 7 drives the transmission main shaft 8021 to rotate, and the transmission main shaft 8021 drives the power disc 8022, the locking slot 8023, the outer ring tooth groove 8024, the stirring shaft 8025 and the inner blade 8026 to rotate synchronously. 012 is inserted into the locking slot 8023. At this time, the power disc 8022 and the locking slot 8023 rotate synchronously to drive the locking block 8012 and the fixing rod 8013 to rotate, and the fixing rod 8013 is inserted into the rotating disk 8031, driving the rotating disk 8031 ​​to rotate synchronously. The rotating disk 8031 ​​drives the connecting frame 8032, the outer ring frame 8033, the connecting rod 8038 and the outer blade 8039 to rotate synchronously. At this time, the power disc 8022 and the outer ring frame 8033 rotate at the same speed, so the outer blade 8039 and the inner blade 8026 rotate as a whole at the same speed. The outer blade 8039 and the inner blade 8026 are spliced ​​into a negative pressure blade-like shape. After the opening and closing mechanism 4 is opened, the mixed liquid is evenly pressed into the purification mechanism 3 for filtration, thereby further improving the purification efficiency.

[0031] In an embodiment of the present invention, the reaction mechanism 2 includes a reaction tank 201, a reaction chamber 202 and an output hole 203. The reaction tank 201 is arranged on the frame 1, the reaction chamber 202 is opened inside the reaction tank 201, the output hole 203 is opened at the bottom of the reaction tank 201, the reaction chamber 202 is connected with the output hole 203, and the output hole 203 is connected with the adaptive opening and closing mechanism 4. In the present invention, the bear bile powder and purified water are injected through the injection pipe 5 and enter the reaction chamber 202 of the reaction tank 201. After being fully mixed and dissolved in the reaction chamber 202, they enter the purification mechanism 3 through the output hole 203 and the adaptive opening and closing mechanism 4 to achieve filtration.

[0032] As another embodiment of the present invention, the purification mechanism 3 includes a purification outer cylinder 301, an attached filter cartridge 302 and a discharge valve 303. The purification outer cylinder 301 is connected to the frame 1 at a position directly below the reaction mechanism 2, the attached filter cartridge 302 is arranged inside the purification outer cylinder 301, the discharge valve 303 is arranged at the bottom of the purification outer cylinder 301, and the output hole 203 is connected to the purification outer cylinder 301. In the present invention, when the mixed liquid enters the purification outer cylinder 301 through the adaptive opening and closing mechanism 4, the attached filter cartridge 302 filters out impurities such as protein, fat, amino acid, sugar, part of the pigment and inorganic salt, and the liquid with a higher purity of ursine total bile acid is obtained by opening the discharge valve 303.

[0033] As another embodiment of the present invention, the adaptive opening and closing mechanism 4 includes a fixed top ring 401, a first long hole 402, a slide rod 403, a moving block 404, a rotating bottom ring 405, a second long hole 406, an outer tooth groove 407, a servo motor 408 and a second gear 409, the fixed top ring 401 is fixedly connected to the bottom end of the reaction mechanism 2, the first long hole 402 is annularly arranged at equal intervals on the fixed top ring 401, the rotating bottom ring 405 is rotatably connected to the top of the purification mechanism 3, and the second long hole 4 06 are opened on the rotating bottom ring 405 in a ring shape with equal intervals, one end of the sliding rod 403 is movably inserted in the first long hole 402, and the other end of the sliding rod 403 is movably inserted in the second long hole 406, the moving block 404 is sleeved on the sliding rod 403, the external tooth groove 407 is opened on the outer wall of the rotating bottom ring 405, the servo motor 408 is arranged on the frame 1, one end of the second gear 409 is connected to the output end of the servo motor 408, and the other end of the second gear 409 is meshed and connected to the external tooth groove 407. In the present invention, the servo motor 408 is driven to drive the second gear 409 to rotate, the second gear 409 is engaged to drive the outer tooth groove 407 to rotate, the outer tooth groove 407 drives the rotating bottom ring 405 to rotate, the rotating bottom ring 405 drives the second long hole 406 to rotate, the second long hole 406 rotates to make the slide bar 403 slide in the second long hole 406 and the first long hole 402, so that the position of the slide bar 403 moves, and the slide bar 403 drives the moving block 404 to move synchronously, such as Figure 6 and Figure 7 As shown, the opening and closing effect is achieved. When the stirring and pressing mechanism 8 is in a mixing and stirring state, the adaptive opening and closing mechanism 4 is in a closed state. When the stirring and pressing mechanism 8 is in a rotating and pressurizing state, the adaptive opening and closing mechanism 4 is in an open state. The adaptive opening and closing mechanism 4 of the present invention can adaptively adjust the size of the flow hole according to the filter flow of the purification mechanism 3, and cooperate with the rotating and pressurizing state of the stirring and pressing mechanism 8 to adjust the pressure of the mixed liquid entering the purification mechanism 3, thereby achieving more precise control, which is beneficial to further improve the extraction quality and efficiency of total bile acid.

[0034] As another embodiment of the present invention, the driving mechanism 7 includes a reduction motor 701 and a cylinder 702. The reduction motor 701 is arranged on the supporting mounting frame 6 at a position directly above the transmission main shaft 8021. The transmission main shaft 8021 is connected to the output end of the reduction motor 701. The cylinder 702 is arranged on the supporting mounting frame 6, and the end of the fixing ring 8014 away from the sliding plate 8011 is connected to the output end of the cylinder 702.

[0035] Working principle: This embodiment provides a method for extracting and purifying total bile acid from bear bile powder, comprising the following steps: S1, raw material conveying operation; First, bear bile powder and purified water are injected into the reaction chamber 202 of the reaction tank 201 through the injection tube 5; S2, state adjustment operation; Select the specific adjustment mode according to the required mixing state or rotating pressurization state; S2.1. If a mixing and dissolving operation is required, the fixed ring 8014 is driven upward by the return stroke of the cylinder 702. The fixed ring 8014 is fixedly sleeved on the sliding plate 8011, driving the sliding plate 8011 to move synchronously. The sliding plate 8011 is fixedly connected to the locking block 8012 through the fixing rod 8013. Therefore, when the cylinder 702 drives the fixed ring 8014 to move upward by the return stroke, the sliding plate 8011, the fixing rod 8013 and the locking block 8012 are synchronously driven to slide on the transmission main shaft 8021, and the locking block 8012 is disengaged from the locking slot 8023 of the power disc 8022. The driving mechanism 7 drives the transmission main shaft 8021 to rotate, and the transmission main shaft 8021 drives the power disc 8022, the locking slot 8023, the outer ring tooth groove 8024, the stirring shaft 8025 and the inner blade 8026 to rotate synchronously. The ring tooth groove 8024 meshes with the first gear 8042 to drive the first gear 8042 to rotate on the ring slide groove 8036. The other side of the first gear 8042 meshes with the inner ring tooth groove 8035 to drive the outer ring frame 8033 to rotate. The outer ring frame 8033 drives the connecting rod 8038, and the connecting rod 8038 drives the outer paddle 8039 to rotate. Since the radius of the power disc 8022 is smaller than the radius of the outer ring frame 8033, there is a speed difference between the power disc 8022 and the outer ring frame 8033, so that the rotation of the inner paddle 8026 and the outer paddle 8039 also produces a speed difference. In the process of mixing and stirring the bear bile powder and purified water for dissolution, the speed difference generated between the inner paddle 8026 and the outer paddle 8039 offsets part of the centrifugal force generated by the stirring rotation, so that the bear bile powder and purified water can be dissolved more fully; S2.2, if a rotary boost operation is required, the fixed ring 8014 is driven downward by the stroke of the cylinder 702, and the fixed ring 8014 is fixedly sleeved on the sliding plate 8011, driving the sliding plate 8011 to move synchronously. The sliding plate 8011 is fixedly connected to the locking block 8012 through the fixing rod 8013. Therefore, when the stroke of the cylinder 702 drives the fixed ring 8014 to move downward, the sliding plate 8011, the fixing rod 8013 and the locking block 8012 are synchronously driven to slide on the transmission main shaft 8021, and the locking block 8012 is inserted into the locking slot 8023 of the power disc 8022. At this time, the driving mechanism 7 drives the transmission main shaft 8021 to rotate, and the transmission main shaft 8021 drives the power disc 8022, the locking slot 8023, the outer ring tooth groove 8024, the stirring shaft 8025 and the inner blade 8 026 rotates synchronously, because the locking card block 8012 is inserted in the locking card slot 8023, at this time, the power disc 8022 and the locking card slot 8023 rotate synchronously to drive the locking card block 8012 and the fixed rod 8013 to rotate, and the fixed rod 8013 is inserted in the rotating disk 8031, driving the rotating disk 8031 ​​to rotate synchronously, and the rotating disk 8031 ​​drives the connecting frame 8032, the outer ring frame 8033, the connecting rod 8038 and the outer blade 8039 to rotate synchronously. At this time, the power disc 8022 and the outer ring frame 8033 rotate at the same speed, so the outer blade 8039 and the inner blade 8026 rotate as a whole at the same speed. The outer blade 8039 and the inner blade 8026 are spliced ​​into a negative pressure blade-like shape. After the opening and closing mechanism 4 is adapted to be opened, the mixed liquid is evenly pressed into the purification mechanism 3 for filtration; S3, adaptive opening and closing operation; The servo motor 408 is driven to rotate the second gear 409, and the meshing of the second gear 409 drives the external tooth groove 407 to rotate, and the external tooth groove 407 drives the rotating bottom ring 405 to rotate, and the rotating bottom ring 405 drives the second long hole 406 to rotate, and the second long hole 406 rotates to make the slide bar 403 slide in the second long hole 406 and the first long hole 402, so that the position of the slide bar 403 moves, and the slide bar 403 drives the moving block 404 to move synchronously to achieve the opening and closing effect. When the stirring and pressing mechanism 8 is in the mixing and stirring state, the opening and closing mechanism 4 is adapted to be in the closed state, and when the stirring and pressing mechanism 8 is in the rotating and pressurizing state, the opening and closing mechanism 4 is adapted to be in the open state; S4, purification operation; When the mixed liquid enters the purification outer cylinder 301 through the adaptive opening and closing mechanism 4, impurities such as protein, fat, amino acid, sugar, some pigments and inorganic salts are filtered out by the attached filter cylinder 302, and the liquid with high purity of ursine total bile acid is obtained by opening the discharge valve 303.

[0036] The embodiments of the present invention disclose preferred embodiments, but are not limited thereto. A person skilled in the art can easily understand the spirit of the present invention based on the above embodiments and make different extensions and changes. However, as long as they do not deviate from the spirit of the present invention, they are all within the protection scope of the present invention.

Claims

1. A method for extracting and purifying total bile acid from bear bile powder, the method being implemented based on a purification device, characterized in that: The machine comprises a frame (1), a reaction mechanism (2) being arranged on the frame (1), a purification mechanism (3) being arranged on the frame (1) at a position directly below the reaction mechanism (2), an adaptive opening and closing mechanism (4) being arranged between the reaction mechanism (2) and the purification mechanism (3), an injection pipe (5) being arranged on the outer wall of the top end of the reaction mechanism (2), a bearing mounting frame (6) being arranged on the top end of the reaction mechanism (2), a driving mechanism (7) being arranged on the bearing mounting frame (6), and a stirring and pressing mechanism (8) being hoisted on the bearing mounting frame (6) at a position directly above the reaction mechanism (2); The stirring and pressing mechanism (8) comprises an adjusting component (801), a main shaft power member (802), an external load-carrying rotating component (803) and an internal rotation component (804); the main shaft power member (802) is connected to the output end of the driving mechanism (7) and is located directly below the bearing mounting frame (6); one end of the adjusting component (801) is connected to the driving mechanism (7); the other end of the adjusting component (801) is movably sleeved on the main shaft power member (802); the external load-carrying rotating component (803) is rotatably sleeved on the main shaft power member (802); the adjusting component (801) is also movably inserted on the external load-carrying rotating component (803); and the internal rotation component (804) is movably arranged at equal intervals in a ring shape at the bottom end of the external load-carrying rotating component (803) and is located between the main shaft power member (802) and the external load-carrying rotating component (803); The driving mechanism (7) drives the regulating component (801) so that the main shaft power component (802), the external load rotating component (803) and the internal rotating component (804) form a mixed stirring state or a rotating pressurized state.

2. A method for extracting and purifying total bile acid from bear bile powder according to claim 1, characterized in that: The main shaft power component (802) comprises a transmission main shaft (8021), a power disc (8022), a locking slot (8023), an outer ring tooth groove (8024), a stirring shaft (8025) and an inner paddle (8026); the transmission main shaft (8021) is connected to the output end of the driving mechanism (7) and is located directly below the bearing mounting frame (6); the power disc (8022) is fixedly connected to the bottom end of the transmission main shaft (8021); the locking slot (8023) ) is provided at the top of the power disc (8022), the outer ring tooth groove (8024) is provided on the outer wall of the power disc (8022), the stirring shaft (8025) is connected to the bottom end of the power disc (8022), the inner blades (8026) are connected to the outer wall of the transmission main shaft (8021) in a ring-shaped and equidistant manner, the locking slot (8023) is adapted to the adjusting component (801), and the outer ring tooth groove (8024) is adapted to the inner rotating component (804).

3. A method for extracting and purifying total bile acid from bear bile powder according to claim 2, characterized in that: The adjustment component (801) comprises a sliding plate (8011), a locking block (8012), a fixing rod (8013) and a fixing ring (8014); the sliding plate (8011) is movably sleeved on the transmission main shaft (8021); the locking block (8012) is movably sleeved on the transmission main shaft (8021) at a position directly below the sliding plate (8011); the sliding plate (8011) and the locking block (8012) are fixedly connected via the fixing rod (8013); the fixing ring (8014) is fixedly sleeved on the outer wall of the sliding plate (8011); and one end of the fixing ring (8014) away from the sliding plate (8011) is connected to the output end of the driving mechanism (7).

4. A method for extracting and purifying total bile acid from bear bile powder according to claim 3, characterized in that: The external load rotation assembly (803) comprises a rotating disk (8031), a connecting frame (8032), an outer ring frame (8033), a top ring plate (8034), an inner ring tooth groove (8035), an annular sliding groove (8036) and an outer paddle member (8037); the rotating disk (8031) is rotatably sleeved on the transmission main shaft (8021); the connecting frame (8032) is fixedly connected to the outer wall of the rotating disk (8031) in an annular shape with equal spacing; the outer ring frame (8033) is fixedly connected to the connecting frame (8032) at a distance of 100 m. At one end away from the rotating disk (8031), the top ring plate (8034) is fixedly arranged on the top end of the inner wall of the outer ring frame (8033), the ring slide groove (8036) is arranged on the bottom end of the top ring plate (8034), the inner ring tooth groove (8035) is arranged on the bottom end of the inner wall of the outer ring frame (8033), the inner ring tooth groove (8035) and the ring slide groove (8036) are adapted to the inner rotating component (804), and the outer paddle member (8037) is fixedly connected to the bottom end of the outer ring frame (8033) in an annular shape with equal spacing; The outer paddle member (8037) comprises a connecting rod (8038) and an outer paddle blade (8039); the connecting rod (8038) is annularly fixedly connected to the bottom end of the outer ring frame (8033) at equal intervals; the outer paddle blade (8039) is fixedly connected to the bottom end of the connecting rod (8038); the outer paddle blade (8039) is adapted to fit the inner paddle blade (8026).

5. A method for extracting and purifying total bile acid from bear bile powder according to claim 4, characterized in that: The inner rotating assembly (804) comprises a sliding rod (8041) and a first gear (8042); the sliding rod (8041) is movably inserted in the annular groove (8036) at equal intervals in a ring shape; the first gear (8042) is connected to the bottom end of the sliding rod (8041); one end of the first gear (8042) is meshedly connected to the outer ring tooth groove (8024); and the other end of the first gear (8042) is meshedly connected to the inner ring tooth groove (8035).

6. A method for extracting and purifying total bile acid from bear bile powder according to claim 5, characterized in that: The reaction mechanism (2) comprises a reaction tank (201), a reaction chamber (202) and an output hole (203); the reaction tank (201) is arranged on the frame (1); the reaction chamber (202) is opened inside the reaction tank (201); the output hole (203) is opened at the bottom end of the reaction tank (201); the reaction chamber (202) is communicated with the output hole (203); and the output hole (203) is communicated with the adaptive opening and closing mechanism (4).

7. A method for extracting and purifying total bile acid from bear bile powder according to claim 6, characterized in that: The purification mechanism (3) comprises a purification outer cylinder (301), an attached filter cartridge (302) and a drain valve (303); the purification outer cylinder (301) is connected to the frame (1) at a position directly below the reaction mechanism (2); the attached filter cartridge (302) is arranged inside the purification outer cylinder (301); the drain valve (303) is arranged at the bottom end of the purification outer cylinder (301); and the output hole (203) is in communication with the purification outer cylinder (301).

8. A method for extracting and purifying total bile acid from bear bile powder according to claim 7, characterized in that: The adaptive opening and closing mechanism (4) comprises a fixed top ring (401), a first long hole (402), a sliding rod (403), a moving block (404), a rotating bottom ring (405), a second long hole (406), an external tooth groove (407), a servo motor (408) and a second gear (409), wherein the fixed top ring (401) is fixedly connected to the bottom end of the reaction mechanism (2), the first long holes (402) are arranged in a circular shape and are evenly spaced on the fixed top ring (401), the rotating bottom ring (405) is rotatably connected to the top end of the purification mechanism (3), and the second long holes (406) are arranged in a circular shape and are evenly spaced on the bottom end. On the rotating bottom ring (405), one end of the sliding rod (403) is movably inserted into the first long hole (402), and the other end of the sliding rod (403) is movably inserted into the second long hole (406). The moving block (404) is sleeved on the sliding rod (403). The external tooth groove (407) is opened on the outer wall of the rotating bottom ring (405). The servo motor (408) is arranged on the frame (1). One end of the second gear (409) is connected to the output end of the servo motor (408), and the other end of the second gear (409) is meshedly connected to the external tooth groove (407).

9. A method for extracting and purifying total bile acid from bear bile powder according to claim 8, characterized in that: The driving mechanism (7) comprises a reduction motor (701) and a cylinder (702); the reduction motor (701) is arranged on the support mounting frame (6) at a position directly above the transmission main shaft (8021); the transmission main shaft (8021) is connected to the output end of the reduction motor (701); the cylinder (702) is arranged on the support mounting frame (6); and the end of the fixing ring (8014) away from the sliding plate (8011) is connected to the output end of the cylinder (702).

10. A method for extracting and purifying total bile acid from bear bile powder according to claim 9, characterized in that: The following steps are involved: S1, raw material conveying operation; First, bear bile powder and purified water are injected into the reaction chamber (202) of the reaction tank (201) through the injection tube (5); S2, state adjustment operation; Select the specific adjustment mode according to the required mixing state or rotating pressurization state; S2.

1. If a mixed dissolving operation is required, the cylinder (702) drives the fixed ring (8014) to move upward through the return stroke. The fixed ring (8014) is fixedly sleeved on the sliding plate (8011), driving the sliding plate (8011) to move synchronously. The sliding plate (8011) is fixedly connected to the locking block (8012) through the fixing rod (8013). Therefore, when the cylinder (702) drives the fixed ring (8014) to move upward through the return stroke, the sliding plate (8011) is synchronously driven. The fixing rod (8013) and the locking block (8012) slide on the transmission main shaft (8021), and the locking block (8012) is disengaged from the locking slot (8023) of the power disc (8022). The driving mechanism (7) drives the transmission main shaft (8021) to rotate, and the transmission main shaft (8021) drives the power disc (8022), the locking slot (8023), the outer ring tooth groove (8024), the stirring shaft (8025) and the inner paddle (8026). The outer ring gear (8024) meshes with the first gear (8042) to drive the first gear (8042) to rotate on the ring groove (8036), and the other side of the first gear (8042) meshes with the inner ring gear (8035) to drive the outer ring frame (8033) to rotate. The outer ring frame (8033) drives the connecting rod (8038), and the connecting rod (8038) drives the outer blade (8039) to rotate. Since the radius of the power disc (8022) is smaller than that of the outer ring frame ( 8033), at this time, there is a speed difference between the power disc (8022) and the outer ring frame (8033), so that the rotation of the inner blade (8026) and the outer blade (8039) also produces a speed difference, so that in the process of mixing and stirring the bear bile powder and purified water for dissolution, the speed difference generated between the inner blade (8026) and the outer blade (8039) offsets part of the centrifugal force generated by the stirring rotation, so that the bear bile powder and purified water can be dissolved more fully; S2.

2. If a rotary boost operation is required, the fixed ring (8014) is driven downward by the stroke of the cylinder (702). The fixed ring (8014) is fixedly mounted on the sliding plate (8011), driving the sliding plate (8011) to move synchronously. The sliding plate (8011) is fixedly connected to the locking block (8012) through the fixing rod (8013). Therefore, when the fixed ring (8014) is driven downward by the stroke of the cylinder (702), the sliding plate (8011) is synchronously driven. ), the fixing rod (8013) and the locking block (8012) slide on the transmission main shaft (8021), and the locking block (8012) is inserted into the locking slot (8023) of the power disc (8022). At this time, the driving mechanism (7) drives the transmission main shaft (8021) to rotate, and the transmission main shaft (8021) drives the power disc (8022), the locking slot (8023), the outer ring tooth groove (8024), the stirring shaft (8025) and the inner paddle (8026) rotate synchronously, because the locking card block (8012) is inserted in the locking card slot (8023), at this time, the power disc (8022) and the locking card slot (8023) rotate synchronously to drive the locking card block (8012) and the fixed rod (8013) to rotate, and the fixed rod (8013) is inserted in the rotating disc (8031), driving the rotating disc (8031) to rotate synchronously, and the rotating disc (8031) drives the connecting frame (8032) and the outer ring frame (8032) to rotate synchronously. 8033), the connecting rod (8038) and the outer blade (8039) rotate synchronously. At this time, the power disc (8022) and the outer ring frame (8033) rotate at the same speed, so the outer blade (8039) and the inner blade (8026) rotate as a whole at the same speed. The outer blade (8039) and the inner blade (8026) are spliced ​​into a shape similar to a negative pressure blade. After the adaptive opening and closing mechanism (4) is opened, the mixed liquid is evenly pressed into the purification mechanism (3) for filtration; S3, adaptive opening and closing operation; The servo motor (408) is driven to rotate the second gear (409), the second gear (409) is meshed to rotate the external tooth groove (407), the external tooth groove (407) drives the rotating bottom ring (405) to rotate, the rotating bottom ring (405) drives the second long hole (406) to rotate, the second long hole (406) rotates to make the slide bar (403) slide in the second long hole (406) and the first long hole (402), so that the position of the slide bar (403) moves, the slide bar (403) drives the moving block (404) to move synchronously, and realizes the opening and closing effect. When the stirring and pressing mechanism (8) is in the mixing and stirring state, the opening and closing mechanism (4) is adapted to be in the closed state, and when the stirring and pressing mechanism (8) is in the rotating and pressurizing state, the opening and closing mechanism (4) is adapted to be in the open state; S4, purification operation; When the mixed liquid enters the purification outer cylinder (301) through the adaptive opening and closing mechanism (4), impurities such as protein, fat, amino acid, sugar, some pigments and inorganic salts are filtered out by the attached filter cylinder (302), and a liquid with a high purity of total bile acid of ursine is obtained by opening the discharge valve (303).

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