A multi-well reference solution preparation instrument

Abstract

This invention discloses a multi-well reference solution preparation instrument, comprising a preparation box, a placement mechanism, a solubilization monitoring mechanism, and a quantitative preparation mechanism. The placement mechanism is used to place several reference containers. The quantitative preparation mechanism quantitatively delivers the solvent from the solvent box to the reference containers. The solubilization monitoring mechanism includes several solubilization monitoring components. This multi-well reference solution preparation instrument, by setting a placement mechanism in the preparation box to hold several reference containers, combined with the use of the quantitative preparation mechanism, enables the solvent in the solvent box to be quantitatively and precisely delivered to the reference containers. The solubilization monitoring mechanism can heat and shake the reference solvent in the reference containers before monitoring the clarity. This reduces the errors caused by different transfer instruments and human judgment during the preparation process, reduces the problem of bias in the true concentration of the reference solvent, and provides more accurate preparation of the reference solvent.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical testing technology, and in particular to a multi-well reference solution preparation instrument. Background Technology

[0002] The accuracy of reference standard preparation is crucial to the results of drug testing. Currently, reference standards are prepared manually, with volumetric flasks used for final volume adjustment. If dilution is involved, pipettes or pipettes are often used to transfer the solution and then bring the volume to the specified level. However, the accuracy of the reference standard during the entire preparation process is often affected by factors such as the increase in preparation steps, the accuracy of the transfer tools, and human judgment differences, leading to deviations in the true concentration of the reference standard. Therefore, to address the above problems, this application provides a multi-well reference standard solution preparation instrument, which achieves more accurate preparation of reference standards while reducing errors caused by different transfer instruments and human judgment. Summary of the Invention

[0003] Purpose of the invention: To provide a multi-well reference solution preparation instrument that can achieve more accurate preparation of reference solutions while reducing errors caused by different transfer instruments and human judgment.

[0004] Technical solution:

[0005] A multi-well reference solution preparation instrument includes a preparation box, a placement mechanism, a solubilization monitoring mechanism, and a quantitative preparation mechanism. The placement mechanism and the solubilization monitoring mechanism are both located inside the preparation box. The quantitative preparation mechanism is located above the preparation box and connected to a solvent tank mounted on a support platform. The placement mechanism is used to place several reference containers. The quantitative preparation mechanism quantitatively delivers the solvent from the solvent tank to the reference containers. The solubilization monitoring mechanism includes several solubilization monitoring components, which are used to heat, shake, and monitor the reference solvent in the several reference containers, respectively.

[0006] The support platform is also equipped with a cleaning and recycling mechanism, which is located on one side of the quantitative preparation mechanism. The support platform is connected to the base via a lifting assembly. The lifting assembly drives the support platform to move up and down along the height direction of the preparation box. The base is connected to the bottom of the preparation box via a moving mechanism. The moving mechanism is used to drive the preparation box to move back and forth below the quantitative preparation mechanism and the cleaning and recycling mechanism, so that after the reference solution in the preparation box is prepared at the quantitative preparation mechanism, the preparation box moves to the cleaning and recycling mechanism to complete the cleaning operation of the reference container.

[0007] The configuration box is also equipped with a drying mechanism, which dries the control container after the cleaning operation is completed.

[0008] In a further embodiment, the placement mechanism includes a placement plate fixed inside the configuration box, the placement plate having a plurality of placement holes for placing control containers, and each placement hole corresponding to a solubilization monitoring component;

[0009] The solubility monitoring component includes a heating element, a shaking element, and a solution clarity monitoring element. The heating element is disposed on the inner wall of the placement hole and wraps around the outside of the control container. The shaking element is located below the placement hole and attached to the bottom of the control container. The solution clarity monitoring element is disposed above the placement hole for monitoring the reference solvent in the control container.

[0010] In a further embodiment, the quantitative delivery mechanism includes a quantitative delivery pump and a plurality of quantitative delivery tubes. The quantitative delivery pump is fixed on the support platform, the suction end of the quantitative delivery pump extends into the solvent tank, and the delivery end of the quantitative delivery pump is connected to the plurality of quantitative delivery tubes through a first main pipe.

[0011] Several quantitative delivery tubes are arranged in a one-to-one correspondence with several control containers, and a first solenoid valve is installed at both ends of each quantitative delivery tube.

[0012] In a further embodiment, the cleaning and recycling mechanism includes a cleaning water delivery pump and a waste liquid recycling pump, both of which are fixed on the support platform. The suction end of the cleaning water delivery pump and the delivery end of the waste liquid recycling pump extend into the cleaning liquid tank and the waste liquid recycling tank, respectively. The delivery end of the cleaning water delivery pump and the suction end of the waste liquid recycling pump are both connected to a second main pipe. The second main pipe is equipped with a cleaning valve and a recycling valve. The recycling valve is used to control the connection between the waste liquid recycling pump and the second main pipe, and the cleaning valve is used to control the connection between the cleaning and recycling pump and the second main pipe.

[0013] The second main pipe is connected to a plurality of cleaning and recovery pipes, and the plurality of cleaning and recovery pipes are arranged in a one-to-one correspondence with the plurality of control containers. A second solenoid valve is provided at one end of each of the plurality of cleaning and recovery pipes that is connected to the second main pipe.

[0014] In a further embodiment, the drying mechanism includes an air supply component located on one side outside the configuration box, a plurality of drying pipes, and a first power component. One end of each of the drying pipes is located inside the configuration box and corresponds to one of the control containers. The other end of each of the drying pipes passes through the configuration box and connects to the air supply component. The air supply component includes a hot air blower and a main air supply pipe. The main air supply pipe inputs the hot air output by the hot air blower into the plurality of drying pipes.

[0015] The air drying duct is in the shape of an inverted "L". The air drying duct includes a vertical air supply section and a horizontal connecting section that are connected to each other. The horizontal connecting section is a bellows-type telescopic structure. The bottom end of the vertical air supply section corresponds to the control container, and the top end is connected to one end of the horizontal connecting section. The other end of the horizontal connecting section is connected to the main air supply duct.

[0016] The first power component is connected to the transverse connecting part for driving the transverse connecting part to move horizontally above the control container along the radial direction of the placement hole.

[0017] In a further embodiment, the first power component includes a telescopic electric cylinder, the fixed end of which is fixed to the configuration box, and the telescopic end is connected to a push plate, which is connected to a plurality of the transverse connecting portions.

[0018] In a further embodiment, the air-drying mechanism further includes a drying element disposed on the inner wall of the configuration box, the drying element including a heating tube.

[0019] In a further embodiment, the moving mechanism includes a moving motor and a moving component, the moving motor being mounted on the base and connected to the configuration box via the moving component;

[0020] The movable component includes a movable nut and a movable lead screw that cooperates with the movable nut. The movable nut is fixedly connected to the bottom of the configuration box. One end of the movable lead screw is installed on the output end of the movable motor, and the other end is rotatably connected to the base.

[0021] In a further embodiment, a sliding connector is provided between the base and the configuration box. The sliding connector includes a slider installed at the bottom of the configuration box, which slides horizontally in a groove opened on the base; this can improve the stability of the cover's movement and coverage.

[0022] In a further embodiment, a covering mechanism is also provided inside the configuration box. The covering mechanism includes two cover plates symmetrically arranged about the center line of the longitudinal direction of the placement plate. The cover plates are connected to a second power member, which drives the two cover plates to move towards each other to cover the top of the control container.

[0023] The second power component includes a power motor and a long rod. The power motor is installed inside the configuration box on one side. One end of the long rod is connected to the output end of the power motor, and the other end is rotatably connected to the inner wall of the configuration box. The long rod is provided with two threaded areas with opposite directions. Each threaded area is threaded with a threaded movable sleeve. Each threaded movable sleeve is fixedly connected to one end of a cover plate.

[0024] The other end of the cover plate is connected to an auxiliary sliding member, which includes a sliding sleeve installed at the other end of the cover plate. The sliding sleeve is slidably fitted onto a sliding rod, which is parallel to the long rod and fixed to the other side inside the configuration box; it can be configured with a vibrating element to maintain the stability of the control container.

[0025] The beneficial effects of this invention are:

[0026] (1) By setting up a placement mechanism in the preparation box that can hold several control containers, and using a quantitative preparation mechanism located above the preparation box, the solvent in the solvent box can be quantitatively and precisely delivered to the corresponding control container through the quantitative preparation mechanism. Furthermore, the solubilization monitoring mechanism set up in the preparation box can heat and shake the reference solvent in the control container before monitoring whether the clarity of the reference solvent meets expectations. In this preparation process, the errors of different transfer instruments and human judgment are reduced, the problem of bias in the true concentration of the reference solvent is reduced, and the reference solvent can be prepared more accurately.

[0027] (2) A cleaning and recycling mechanism is also provided on one side of the quantitative configuration mechanism. After the configuration box completes the configuration operation, the moving mechanism on the base moves the configuration box to the cleaning and recycling mechanism. The cleaning and recycling mechanism can clean the control container. It is not necessary to manually remove the control container and clean it separately. It is more convenient and the efficiency is also effectively improved. Attached Figure Description

[0028] Figure 1 This is a schematic cross-sectional view of the right side of the present invention.

[0029] Figure 2 This is a schematic diagram of the left side structure of the present invention.

[0030] Figure 3 This is a partial cross-sectional view of the front of the present invention.

[0031] Figure 4 This is the invention Figure 1 Enlarged structural diagram at point A in the middle.

[0032] Figure 5 This is the invention Figure 3 Enlarged structural diagram at point B.

[0033] Figure 6 This is a top view of the configuration box structure of the present invention.

[0034] Figure 7 This is a schematic diagram of the structure of the present invention under solvent delivery conditions on the right side.

[0035] Figure 8 This is a top view of the support platform structure of the present invention.

[0036] Figure 9 This is a top view of the base structure of the present invention.

[0037] The attached diagram is labeled as follows: 1. Configuration box; 2. Placement plate; 21. Placement hole; 22. Control container; 23. Heating element; 24. Shaking element; 25. Solution clarity monitoring element; 3. Quantitative delivery mechanism; 31. Solvent tank; 4. Support platform; 41. Lifting assembly; 5. Cleaning and recovery mechanism; 51. Cleaning liquid tank; 52. Waste liquid recovery tank; 6. Base; 61. Moving mechanism; 62. Sliding connector; 7. Drying mechanism; 71. Drying pipe; 72. Air supply assembly; 73. First power component; 8. Drying component; 9. Covering mechanism; 91. Cover plate; 92. Second power component; 93. Auxiliary sliding component. Detailed Implementation

[0038] In the following description, numerous specific details are set forth in order to provide a more thorough understanding of the invention. However, it will be apparent to those skilled in the art that the invention can be practiced without one or more of these details. In other instances, certain technical features well-known in the art have not been described in order to avoid obscuring the invention.

[0039] The present invention will be further described in detail below with reference to the accompanying drawings.

[0040] Reference Figure 1-9This invention discloses a multi-well reference solution preparation instrument, comprising a preparation box 1, a placement mechanism, a solubilization monitoring mechanism, and a quantitative preparation mechanism. The placement mechanism and the solubilization monitoring mechanism are both located within the preparation box 1. The quantitative preparation mechanism is located above the preparation box 1 and connected to a solvent tank 31 mounted on a support platform 4. The placement mechanism is used to place several reference containers 22. The quantitative preparation mechanism quantitatively delivers the solvent from the solvent tank 31 to the reference containers 22 to obtain the reference solvent. The solubilization monitoring mechanism includes several solubilization monitoring components, which are used to heat, shake, and monitor the reference solvent in the several reference containers 22 respectively. A cleaning and recovery mechanism 5 is also provided on the support platform 4. Located on one side of the quantitative preparation mechanism, the support platform 4 is connected to the base 6 via a lifting assembly 41. The lifting assembly 41 drives the support platform 4 to move up and down along the height direction of the preparation box 1. The lifting assembly 41 includes a lifting electric cylinder. The base 6 is connected to the bottom of the preparation box 1 via a moving mechanism 61. The moving mechanism 61 is used to drive the preparation box 1 to move back and forth below the quantitative preparation mechanism and the cleaning and recovery mechanism 5, so that after the reference solution in the preparation box 1 is prepared at the quantitative preparation mechanism, the preparation box 1 moves to the cleaning and recovery mechanism 5 to complete the cleaning operation of the reference container 22. The preparation box 1 is also equipped with a drying mechanism 7, which performs a drying operation on the reference container 22 after the cleaning operation is completed.

[0041] The placement mechanism includes a placement plate 2 fixed inside the configuration box 1. The placement plate 2 has several placement holes 21 for placing control containers 22. Each placement hole 21 corresponds to a solubility monitoring component. The solubility monitoring component includes a heating element 23, a shaking element 24, and a solution clarity monitoring element 25. The heating element 23 is located on the inner wall of the placement hole 21 and wraps around the outside of the control container 22. The shaking element 24 is located below the placement hole 21 and fits against the bottom of the control container 22. The solution clarity monitoring element 25 is located above the placement hole 21 to monitor the reference solvent in the control container 22. The heating element 23 includes a heating ring, the shaking element 24 includes a vortex oscillator, and the solution clarity monitoring element 25 includes a camera. The oscillating element 24 and the solution clarity monitoring element 25 are both electrically connected to the background control system, thereby obtaining control signals and adjusting the operating parameters of each component according to different needs. For poorly soluble or high-concentration reference standards, a heating module is selected, and a heating template is used to control the heating element 23. The heating temperature and time can be set. The oscillating module can control the oscillating element 24, and the oscillation frequency and time can be set to ensure that the reference standard is fully dissolved in the solution. The solution clarity monitoring module controls the solution clarity monitoring element 25 to detect the clarity of the prepared reference standard solution. Based on the results, it can be determined whether the reference standard is completely dissolved, whether there are undissolved fine particles (i.e., invisible to the naked eye), and whether the solution is a homogeneous system, i.e., whether the clarity values ​​of different parts of the solution are consistent, so as to determine the degree of dissolution of the reference standard solution.

[0042] The quantitative delivery mechanism 3 includes a quantitative delivery pump and several quantitative delivery tubes. The quantitative delivery pump is fixed on the support platform 4, and its suction end extends into the solvent tank 31. The delivery end of the quantitative delivery pump is connected to the several quantitative delivery tubes through a first main pipe. Each of the several quantitative delivery tubes corresponds to one of the several control containers 22. A first solenoid valve is installed at both ends of each quantitative delivery tube. According to the configuration requirements, the quantitative delivery pump first draws a fixed amount of solvent from the solvent tank 31, and then the quantitative delivery tube corresponding to the control container 22 connected to the first main pipe... The first solenoid valve opens, allowing the solvent in the first main tube to enter the quantitative delivery tube according to the configuration. The first main tube is in the shape of an inverted "T". At this time, the first solenoid valve at the end of the quantitative delivery tube facing the control container 22 is in the closed state. According to the configuration requirements, when one or more quantitative delivery tubes are all filled with a certain amount of solvent, the lifting component 41 drives the support platform 4 to descend until the lower part of the quantitative delivery tube enters the control container 22. At this time, the closed first solenoid valve opens, allowing the solvent to enter the control container 22 from the quantitative delivery tube, preventing the solvent from splashing to the outside when flowing out of the quantitative delivery tube.

[0043] The cleaning and recycling mechanism 5 includes a cleaning water delivery pump and a waste liquid recycling pump, both of which are fixed on the support platform 4. The suction end of the cleaning water delivery pump and the delivery end of the waste liquid recycling pump extend into the cleaning liquid tank 51 and the waste liquid recycling tank 52, respectively. Both the delivery end of the cleaning water delivery pump and the suction end of the waste liquid recycling pump are connected to a second main pipe. The second main pipe is equipped with a cleaning valve and a recycling valve. The recycling valve controls the connection between the waste liquid recycling pump and the second main pipe, and the cleaning valve controls the connection between the cleaning and recycling pump and the second main pipe. A plurality of cleaning and recycling pipes are connected to the second main pipe, and each of the cleaning and recycling pipes corresponds one-to-one with one of the control containers 22. A plurality of cleaning and recycling pipes are connected to the second main pipe... Each end is equipped with a second solenoid valve, and the second main pipe is in the shape of an "I". When the control container 22 needs to be cleaned, the configuration box 1 moves to the bottom of the cleaning and recovery mechanism 5, and the support platform 4 descends, so that the cleaning and recovery pipe approaches and enters the control container 22. The cleaning valve and the cleaning water delivery pump are opened, and the second solenoid valve on the cleaning and recovery pipe of the control container 22 that needs to be cleaned is also opened. This allows the cleaning water delivery pump to input the cleaning liquid in the cleaning liquid tank 51 into the control container 22 through the cleaning and recovery pipe opened at the corresponding position to complete the cleaning operation. After that, the cleaning water delivery pump and the cleaning valve are closed, and the waste liquid recovery pump and the recovery valve are opened. The waste liquid recovery pump can then draw and recover the waste liquid after cleaning into the waste liquid recovery tank 52 through the cleaning and recovery pipe with the second solenoid valve opened. Then the support platform 4 is raised, and the control container 22 completes the cleaning operation.

[0044] The air-drying mechanism 7 includes an air supply assembly 72 located on one side of the configuration box 1, several air-drying pipes 71, and a first power component 73. One end of each of the air-drying pipes 71 is located inside the configuration box 1 and corresponds one-to-one with each of the reference containers 22. The other end of each of the air-drying pipes 71 passes through the configuration box 1 and connects to the air supply assembly 72. The air supply assembly 72 includes a hot air blower and a main air supply pipe. The main air supply pipe inputs the hot air output by the hot air blower into the several air-drying pipes 71. Each air-drying pipe 71 is equipped with an opening and closing solenoid valve between it and the main air supply pipe. Selectively opening and closing the solenoid valve connects the corresponding air-drying pipe 71 and the main air supply pipe. The air-drying pipes 71 are inverted "L" shapes. 1 includes a vertical air supply section and a horizontal connecting section that are interconnected. The horizontal connecting section is an accordion-style telescopic structure. The bottom end of the vertical air supply section corresponds to the control container 22, and the top end is connected to one end of the horizontal connecting section. The other end of the horizontal connecting section is connected to the main air supply pipe. The first power component 73 is connected to the horizontal connecting section to drive the horizontal connecting section to move horizontally above the control container 22 along the radial direction of the placement hole 21. After cleaning is completed, the first power component 73 drives the horizontal connecting section to extend and approach the control container 22 until the bottom end of the vertical air supply section corresponds to the top of the control container 22. Then, the hot air blower and the corresponding opening and closing solenoid valve are turned on to complete the heating and drying operation of the control container 22 by delivering hot air.

[0045] The first power component 73 includes a telescopic electric cylinder. The fixed end of the telescopic electric cylinder is fixed on the configuration box 1, and the telescopic end is connected to a push plate. The push plate is connected to several of the transverse connecting parts. When the telescopic electric cylinder extends or retracts, the push plate can simultaneously drive several air drying pipes 71 to complete the telescopic movement. When cleaning, recycling and quantitative configuration are performed, the telescopic electric cylinder retracts to the minimum position. At this time, the air drying pipes 71 are far away from the symmetrical containers and will not obstruct the descending quantitative conveying pipe and cleaning and recycling pipe.

[0046] The air-drying mechanism 7 also includes a drying component 8, which is disposed on the inner wall of the configuration box 1. The drying component 8 includes a heating tube, which can be turned on during the air-drying operation to improve the efficiency of heating and air-drying.

[0047] The moving mechanism 61 includes a moving motor and a moving component. The moving motor is mounted on the base 6 and connected to the configuration box 1 through the moving component. The moving component includes a moving nut and a moving screw that cooperates with the moving nut. The moving nut is fixedly connected to the bottom of the configuration box 1. One end of the moving screw is mounted on the output end of the moving motor, and the other end is rotatably connected to the base 6. When the moving motor is running, the moving screw rotates, thereby driving the moving nut and the configuration box 1 to move along the length of the moving screw to complete the configuration cleaning operation.

[0048] A sliding connector 62 is also provided between the base 6 and the configuration box 1. The sliding connector 62 includes a slider installed at the bottom of the configuration box 1. The slider slides horizontally in a groove opened on the base 6. The sliding direction and sliding range of the slider in the groove are consistent with the moving direction and moving direction of the moving nut on the moving screw.

[0049] The configuration box 1 is also equipped with a covering mechanism 9, which includes two cover plates 91 symmetrically arranged about the center line of the placement plate 2 along its length. The cover plates 91 are connected to a second power component 92, which drives the two cover plates 91 to move towards each other to cover the top of the control container 22. A flexible rubber layer is provided on the side of the cover plate 91 facing the top of the control container 22, so that excessive friction is avoided when the cover plate 91 moves to the top of the control container 22, and the sealing performance is also good. The sum of the areas of the two cover plates 91 is equal to the area of ​​the placement plate 2, thus enabling them to completely cover and close several placement holes 21 when they move towards each other, improving the stability of the control container 22 during vibration. The second power component 92 includes a power motor and a long rod. The power motor is installed inside the configuration box 1, and one end of the long rod is connected to the output end of the power motor, while the other end is rotatably connected to the inner wall of the configuration box 1. The long rod has two threaded areas with opposite directions. Each threaded area is threaded with a threaded movable sleeve, and each threaded movable sleeve is fixedly connected to one end of a cover plate 91. The other end of the cover plate 91 is connected to an auxiliary sliding member 93. The auxiliary sliding member 93 includes a sliding sleeve installed at the other end of the cover plate 91. The sliding sleeve is slidably mounted on a sliding rod. The sliding rod is parallel to the long rod and fixed to the other side inside the configuration box 1. After the solvent enters the control container 22, the support platform 4 rises, and the power motor runs, causing the two cover plates 91 to move towards each other until the two cover plates 91 are pressed together and closed on the top of the control container 22 to facilitate the shaking operation. Since the cover plates 91 are located below the solution clarity monitoring device 25 and the air drying pipe 71, when the two cover plates 91 are unfolded and moved to the maximum opposite position, the solution clarity monitoring device 25 can detect the solvent in the control container 22, and the movement of the air drying pipe 71 will not obstruct the unfolded cover plates 91.

[0050] The implementation principle of this invention is as follows: the solute is first added to the corresponding control container 22, and then the quantitative delivery mechanism 3 is opened so that the solvent in the solvent tank 31 is quantitatively transferred to the quantitative delivery tube at the corresponding position. The lifting component 41 is operated to lower the support platform 4, and the quantitative delivery tube is brought close to the control container 22 to input the solvent into the control container 22. The heating element 23 and the shaking element 24 are turned on to heat and shake the solute and solvent, thereby improving the preparation efficiency. Then, the solvent is monitored and identified by the solution clarity monitoring element 25. After the preparation is completed, the preparation box 1 is moved to the cleaning and recovery mechanism 5 by the moving mechanism 61, and the support platform 4 is lowered again. The control container 22 is cleaned by the cleaning and recovery mechanism 5 and the waste liquid after cleaning is recovered.

[0051] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

[0052] The preferred embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the specific details of the above embodiments. Within the scope of the technical concept of the present invention, various equivalent transformations can be made to the technical solutions of the present invention, and all such equivalent transformations fall within the protection scope of the present invention.

Claims

1. A multi-well standard solution preparation instrument, characterized in that: The device includes a preparation box, a placement mechanism, a solubility monitoring mechanism, and a quantitative preparation mechanism. The placement mechanism and the solubility monitoring mechanism are both located inside the preparation box. The quantitative preparation mechanism is located above the preparation box and connected to a solvent tank on a support platform. The placement mechanism is used to place several control containers. The quantitative preparation mechanism quantitatively delivers the solvent from the solvent tank to the control containers. The solubility monitoring mechanism includes several solubility monitoring components, which are used to heat, shake, and monitor the reference solvent in the several control containers, respectively. The support platform is also equipped with a cleaning and recycling mechanism, which is located on one side of the quantitative preparation mechanism. The support platform is connected to the base via a lifting assembly. The lifting assembly drives the support platform to move up and down along the height direction of the preparation box. The base is connected to the bottom of the preparation box via a moving mechanism. The moving mechanism is used to drive the preparation box to move back and forth below the quantitative preparation mechanism and the cleaning and recycling mechanism, so that after the reference solution in the preparation box is prepared at the quantitative preparation mechanism, the preparation box moves to the cleaning and recycling mechanism to complete the cleaning operation of the reference container. The placement mechanism includes a placement plate fixed inside the configuration box. The placement plate has several placement holes for placing control containers. Each placement hole is correspondingly provided with a solubility monitoring component. The solubility monitoring component includes a heating element, a shaking element, and a solution clarity monitoring element. The heating element is located on the inner wall of the placement hole and wraps around the outside of the control container. The shaking element is located below the placement hole and attached to the bottom of the control container. The solution clarity monitoring element is located above the placement hole for monitoring the reference solvent in the control container. The configuration box is also equipped with a drying mechanism, which dries the control container after the cleaning operation is completed.

2. The multi-well reference solution preparation instrument according to claim 1, characterized in that: The quantitative preparation mechanism includes a quantitative delivery pump and several quantitative delivery tubes. The quantitative delivery pump is fixed on the support platform. The suction end of the quantitative delivery pump extends into the solvent tank. The delivery end of the quantitative delivery pump is connected to the several quantitative delivery tubes through a first main pipe. Several quantitative delivery tubes are arranged in a one-to-one correspondence with several control containers, and a first solenoid valve is installed at both ends of each quantitative delivery tube.

3. The multi-well reference solution preparation instrument according to claim 1, characterized in that: The cleaning and recycling mechanism includes a cleaning water delivery pump and a waste liquid recycling pump, both of which are fixed on the support platform. The suction end of the cleaning water delivery pump and the delivery end of the waste liquid recycling pump extend into the cleaning liquid tank and the waste liquid recycling tank, respectively. The delivery end of the cleaning water delivery pump and the suction end of the waste liquid recycling pump are both connected to a second main pipe. The second main pipe is equipped with a cleaning valve and a recycling valve. The recycling valve is used to control the connection between the waste liquid recycling pump and the second main pipe, and the cleaning valve is used to control the connection between the cleaning water delivery pump and the second main pipe. The second main pipe is connected to a plurality of cleaning and recovery pipes, and the plurality of cleaning and recovery pipes are arranged in a one-to-one correspondence with the plurality of control containers. A second solenoid valve is provided at one end of each of the plurality of cleaning and recovery pipes that is connected to the second main pipe.

4. The multi-well standard solution preparation apparatus according to claim 1, characterized in that: The air drying mechanism includes an air supply component located on one side of the outside of the configuration box, a plurality of air drying pipes and a first power component. One end of each of the plurality of air drying pipes is located inside the configuration box and is arranged in a one-to-one correspondence with a plurality of the control containers. The other end of each of the plurality of air drying pipes passes through the configuration box and is connected to the air supply component. The air supply component includes a hot air blower and a main air supply pipe. The main air supply pipe inputs the hot air output by the hot air blower into the plurality of air drying pipes. The air drying duct is in the shape of an inverted "L". The air drying duct includes a vertical air supply section and a horizontal connecting section that are connected to each other. The horizontal connecting section is a bellows-type telescopic structure. The bottom end of the vertical air supply section corresponds to the control container, and the top end is connected to one end of the horizontal connecting section. The other end of the horizontal connecting section is connected to the main air supply duct. The first power component is connected to the transverse connecting part for driving the transverse connecting part to move horizontally above the control container along the radial direction of the placement hole.

5. The multi-well reference solution preparation instrument according to claim 4, characterized in that: The first power component includes a telescopic electric cylinder, the fixed end of which is fixed to the configuration box, and the telescopic end is connected to a push plate, which is connected to several of the transverse connecting parts.

6. The multi-well reference solution preparation instrument according to claim 4, characterized in that: The air-drying mechanism further includes a drying component, which is disposed on the inner wall of the configuration box and includes a heating tube.

7. The multi-well standard solution preparation apparatus according to claim 1, characterized in that: The moving mechanism includes a moving motor and a moving component. The moving motor is mounted on the base and connected to the configuration box through the moving component. The movable component includes a movable nut and a movable lead screw that cooperates with the movable nut. The movable nut is fixedly connected to the bottom of the configuration box. One end of the movable lead screw is installed on the output end of the movable motor, and the other end is rotatably connected to the base.

8. A multi-well reference solution preparation apparatus according to claim 7, characterized in that: A sliding connector is also provided between the base and the configuration box. The sliding connector includes a slider installed at the bottom of the configuration box, and the slider slides horizontally in a groove opened on the base.

9. A multi-well reference solution preparation apparatus according to claim 1, characterized in that: The configuration box is also equipped with a covering mechanism, which includes two cover plates symmetrically arranged about the center line of the length direction of the placement plate. The cover plates are connected to a second power component, which drives the two cover plates to move towards each other to cover the top of the control container. The second power component includes a power motor and a long rod. The power motor is installed inside the configuration box on one side. One end of the long rod is connected to the output end of the power motor, and the other end is rotatably connected to the inner wall of the configuration box. The long rod is provided with two threaded areas with opposite directions. Each threaded area is threaded with a threaded movable sleeve. Each threaded movable sleeve is fixedly connected to one end of a cover plate. The other end of the cover plate is connected to an auxiliary sliding member, which includes a sliding sleeve installed at the other end of the cover plate. The sliding sleeve is slidably fitted onto a sliding rod, which is parallel to the long rod and fixed to the other side inside the configuration box.

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