Composition containing chlorine dioxide and method for preparing chlorine dioxide tablet

Abstract

The invention provides a composition containing chlorine dioxide and a method for preparing a chlorine dioxide tablet, the composition comprises a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, the stabilizer is selected from one or more than two of hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride, and after the composition is prepared into the tablet, the corrosion inhibitor is selected from one or more than two of hydroxypropyl-beta-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride. After activation, the use liquid has good stability, can be stably stored for 6 months, and has low corrosion to metals, so that the problems that the use liquid of the activated chlorine dioxide tablet is not easy to store and has strong corrosion to metals at present can be well solved.

Description

Technical Field

[0001] The present application relates to the field of disinfection technology, and in particular to a composition containing chlorine dioxide and a method for preparing chlorine dioxide tablets. Background Art

[0002] Chlorine dioxide was discovered by Sir Humphrey Davy in 1811, and around 1940, reports began to appear on its use in pulp bleaching and drinking water treatment. 2 When used at a pH level of 3.0 to 8.0, it will not form carcinogenic byproducts such as dioxins, chloroform, and haloacetic acids. 2 O, NaCl, CO 2 , and it does not combine with phenols to form toxic chlorophenols. Low concentrations of chlorine dioxide are considered harmless to humans, animals and plants. The oxidative activity of chlorine dioxide is 2.63 times that of chlorine gas, and its effect in killing bacteria, germs, algae and zooplankton is better than liquid chlorine. Due to the characteristics of high efficiency and low toxicity of chlorine dioxide, it has been recognized by the World Health Organization as an Al-level high-efficiency fungicide and a fungicide with excellent performance. At present, its application areas have involved water treatment, papermaking, food, medical and health, aquaculture and other industries.

[0003] Chlorine dioxide is a gas at room temperature. It is unstable, easily decomposed by light, and prone to low-level explosions, which makes it inconvenient to store and transport, thus affecting its widespread use. So people began to look for methods to produce stable chlorine dioxide solutions and solid chlorine dioxide preparations.

[0004] Chlorine dioxide is unstable in aqueous solution and will decay on its own. Chen Bingqi reported that ClO 2 Attenuation can occur at room temperature. Under acidic conditions, ClO 2 The decay product is Cl - Mainly, with a small amount of ClO under neutral conditions 2 - Under alkaline conditions, ClO 2 - and a small amount of ClO 3 -Mainly. There are also many external factors that affect the stability of chlorine dioxide, such as temperature, light, metal ions, pH value, microorganisms, etc. The short storage period of chlorine dioxide is the biggest factor restricting the large-scale promotion of chlorine dioxide. The emergence of chlorine dioxide tablets has solved the problem of short storage period, and the storage period of chlorine dioxide tablets can reach more than two years. However, even after the chlorine dioxide tablets are formulated into a liquid for use, the storage period of the liquid for use generally does not exceed one month. At present, the research on chlorine dioxide tablets is mostly to ensure the stability of the tablets, and there is less research on the stability of the liquid after activation. In addition, chlorine dioxide has a certain degree of corrosion to metals such as carbon steel, copper, and aluminum at different concentrations, especially to carbon steel. This also limits the application of chlorine dioxide to a certain extent, so it is particularly important to reduce the corrosiveness of the chlorine dioxide liquid for use. Summary of the invention

[0005] Based on the above problems, the present application provides a composition containing chlorine dioxide and a method for preparing chlorine dioxide tablets. After the composition containing chlorine dioxide is made into tablets and activated, the liquid stability is good and the corrosion to metal is low.

[0006] The specific technical solutions of this application are as follows:

[0007] The present invention provides a composition containing chlorine dioxide, which comprises a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, wherein the stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

[0008] Preferably, for the above-mentioned composition, the corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organosiloxane ketone.

[0009] For any of the above compositions, the composition further comprises an activator, a disintegrant, a binder and a lubricant.

[0010] For the above-mentioned composition, wherein, by mass percentage in the composition, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

[0011] For the above-mentioned composition, wherein the activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid; and / or

[0012] The disintegrant comprises sodium bicarbonate and citric acid, or comprises sodium bicarbonate and malic acid; and / or

[0013] The binder is selected from one or more of polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and polyethylene glycol; and / or

[0014] The lubricant is selected from one or more of talc, magnesium stearate and micro powder silica gel.

[0015] For any of the above-mentioned compositions, the composition is in the form of a tablet.

[0016] The present application provides a method for preparing a chlorine dioxide tablet, which comprises:

[0017] Mixing and grinding a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture;

[0018] Mixing and grinding the activator and the disintegrant to obtain a second mixture;

[0019] The first mixture and the second mixture are mixed and tabletted to obtain chlorine dioxide tablets;

[0020] The corrosion inhibitor is mixed and crushed with the chlorine dioxide precursor, the binder, the stabilizer and the lubricant to obtain a first mixture, or the corrosion inhibitor is mixed and crushed with the activator and the disintegrant to obtain a second mixture.

[0021] For the above method, wherein, by weight percentage in the composition, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

[0022] For the above method, wherein the activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid; and / or

[0023] The disintegrant comprises sodium bicarbonate and citric acid, or comprises sodium bicarbonate and malic acid; and / or

[0024] The binder is selected from one or more of polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and polyethylene glycol; and / or

[0025] The lubricant is selected from one or more of talc, magnesium stearate and micro-powder silica gel; and / or

[0026] The stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride; and / or

[0027] The corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organic siloxane ketone.

[0028] Effects of the Invention

[0029] After the composition described in the present application is made into tablets and activated, the liquid used has good stability and can be stably stored for 6 months, and has low corrosion to metals. This can well solve the problem that the liquid used after activation of chlorine dioxide tablets is difficult to store and has strong corrosion to metals. DETAILED DESCRIPTION

[0030] The present application is described in detail below in conjunction with the described embodiments. Although specific embodiments of the present application are shown, it should be understood that the present application can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present application and to enable the scope of the present application to be fully communicated to those skilled in the art.

[0031] It should be noted that certain words are used in the specification and claims to refer to specific components. Those skilled in the art should understand that technicians may use different nouns to refer to the same component. This specification and claims do not use the difference in nouns as a way to distinguish components, but use the functional differences of components as the criterion for distinction. As mentioned throughout the specification and claims, "including" or "comprising" are open-ended terms and should be interpreted as "including but not limited to". The subsequent description of the specification is a preferred embodiment of the present application, but the description is based on the general principles of the specification and is not intended to limit the scope of the present application. The scope of protection of the present application shall be determined by the attached claims.

[0032] The present application provides a composition containing chlorine dioxide, which comprises a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor, wherein the stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

[0033] The chlorine dioxide precursor may be a substance commonly used in the art, such as sodium chlorite, potassium chlorite, calcium chlorite, magnesium chlorite, barium chlorite, etc., preferably sodium chlorite.

[0034] In some embodiments, the corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organosiloxane ketone.

[0035] In some embodiments, the composition further comprises an activator, a disintegrant, a binder, and a lubricant.

[0036] In the present application, the activator, disintegrant, binder and lubricant are commonly used in the art, and those skilled in the art are not limited in any way, and they can be routinely selected as needed. For example, the activator can be citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum chloride and phytic acid or a combination thereof;

[0037] The disintegrant may include sodium bicarbonate and citric acid, or sodium bicarbonate and malic acid, etc.;

[0038] The binder can be polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, polyethylene glycol, or a combination thereof;

[0039] The lubricant can be talc, magnesium stearate, micro powder silica gel, or a combination thereof.

[0040] In some embodiments, based on the mass percentage in the composition, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

[0041] For example, the chlorine dioxide precursor may be 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, etc., in terms of mass percentage in the composition;

[0042] The activator can be 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, etc.;

[0043] The disintegrant is 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, etc.;

[0044] The adhesive may be 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, etc.;

[0045] The stabilizer is 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.65%, 0.7%, 0.75%, 0.8%, 0.85%, 0.9%, 0.95%, 1%, etc.;

[0046] The corrosion inhibitor can be 0.05%, 006%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, etc.;

[0047] The lubricant can be 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, etc.

[0048] In the present application, for the stabilizer, when two or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride are selected, any combination can be made, and one of the components in the combination shall not be less than one tenth of the other component, as long as the content of the stabilizer is within the above range. For example, when a combination of hydroxypropyl-β-cyclodextrin and sodium silicate is used as a stabilizer, the mass ratio (m 羟丙基-β-环糊精 :m 硅酸钠 ) can be 10:1 to 1:10. Similarly, when a combination of sodium hexametaphosphate and boron nitride is used as a stabilizer, the mass ratio of the two (m 六偏磷酸钠 :m 氮化硼 ) can be from 10:1 to 1:10;

[0049] For example, the mass ratio of hydroxypropyl-β-cyclodextrin and sodium silicate (m 羟丙基-β-环糊精 :m 硅酸钠 ) can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.;

[0050] The mass ratio of sodium hexametaphosphate and boron nitride (m 六偏磷酸钠 :m 氮化硼 ) can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

[0051] Similarly, for corrosion inhibitors, when two or more are selected from hydroxyethylidene diphosphonic acid, sodium salt of methylbenzotriazole, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organosiloxane ketone, they can be combined arbitrarily, and one of the components in the combination shall not be less than one tenth of the other component, as long as the content of the corrosion inhibitor is within the above range.

[0052] For example, when a combination of hydroxyethylidene diphosphonic acid and methylbenzotriazole sodium salt is used as a corrosion inhibitor, the mass ratio of the two (m 羟基乙叉二膦酸 :m 甲基苯并三氮唑钠盐 ) can be 10:1 to 1:10. Similarly, when a combination of azaphenyl ring polyaminocaproic acid and organosiloxane ketone is used as a corrosion inhibitor, the mass ratio of the two (m 氮杂苯环多氨基己酸 :m 有机硅氧烷酮 ) can be from 10:1 to 1:10;

[0053] For example, the mass ratio of hydroxyethylidene diphosphonic acid and methylbenzotriazole sodium salt (m 羟基乙叉二膦酸 :m 甲基苯并三氮唑钠盐 ) can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.;

[0054] The mass ratio of azaphenyl ring polyaminocaproic acid and organosiloxane ketone (m 氮杂苯环多氨基己酸 :m 有机硅氧烷酮 ) can be 10:1, 9:1, 8:1, 7:1, 6:1, 5:1, 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

[0055] In some embodiments, the composition is in the form of a tablet.

[0056] The composition described in the present application, after being made into tablets and activated, has good stability in the use liquid and can be stably stored for more than 6 months, while in the prior art, the use liquid can only be stored for about one month after activation; and the corrosion to metals is relatively low, with basically no corrosion to some metals and only slight corrosion to some metals.

[0057] The present application provides a method for preparing a chlorine dioxide tablet, which comprises:

[0058] Mixing and grinding a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture;

[0059] Mixing and grinding the activator and the disintegrant to obtain a second mixture;

[0060] The first mixture and the second mixture are mixed and tabletted to obtain chlorine dioxide tablets;

[0061] The corrosion inhibitor is mixed and crushed with the chlorine dioxide precursor, the binder, the stabilizer and the lubricant to obtain a first mixture, or the corrosion inhibitor is mixed and crushed with the activator and the disintegrant to obtain a second mixture.

[0062] In the present application, the specific corrosion inhibitor can be mixed and crushed with the chlorine dioxide precursor, the binder, the stabilizer and the lubricant to obtain a first mixture, or mixed and crushed with the activator and the disintegrant to obtain a second mixture according to its performance requirements.

[0063] For example, when the corrosion inhibitor is hydroxyethylidene diphosphonic acid and / or methylbenzotriazole sodium salt, it can be mixed with the activator and the disintegrant and crushed to obtain a second mixture;

[0064] When the corrosion inhibitor is azobenzene ring polyaminocaproic acid and / or organosiloxane ketone, it can be mixed and crushed with a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture.

[0065] In some embodiments, when preparing the second mixture, the activator, disintegrant and optional corrosion inhibitor are baked before pulverization, preferably in an oven at 50-60° C., preferably for 12-24 hours.

[0066] In some embodiments, during the preparation of the chlorine dioxide tablet, the temperature is 20-30° C., and / or the relative humidity is 20-40%.

[0067] For example, the temperature may be 20°C, 21°C, 22°C, 23°C, 24°C, 25°C, 26°C, 27°C, 28°C, 29°C, 30°C, etc.;

[0068] The relative humidity can be 20%, 22%, 24%, 26%, 28%, 30%, 32%, 34%, 36%, 38%, 40%, etc.

[0069] In some embodiments, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%. In some embodiments, the activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum chloride and phytic acid; and / or

[0070] The disintegrant comprises sodium bicarbonate and citric acid, or comprises sodium bicarbonate and malic acid; and / or

[0071] The binder is selected from one or more of polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and polyethylene glycol; and / or

[0072] The lubricant is selected from one or more of talc, magnesium stearate and micro-powder silica gel; and / or

[0073] The stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride; and / or

[0074] The corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organic siloxane ketone.

[0075] The chlorine dioxide tablets prepared by the above-mentioned method in the present application are very stable in use liquid after activation, can be stably stored for 6 months, and have little corrosion to metals.

[0076] Example

[0077] The present application provides a general and / or specific description of the materials and test methods used in the experiments. In the following examples, unless otherwise specified, % means wt%, i.e., weight percentage. The reagents or instruments used without indicating the manufacturer are all conventional reagent products that can be obtained commercially.

[0078] Example 1

[0079] (1) Add a chlorine dioxide precursor, a binder, a stabilizer and a lubricant into a pulverizer and grind the powder. Pass the powder through a 100-mesh sieve to obtain a first mixture.

[0080] The chlorine dioxide precursor is sodium chlorite, and the dosage is 500g.

[0081] The adhesive is polyvinyl pyrrolidone K30, and the amount used is 80g.

[0082] The stabilizer is a mixture of hydroxypropyl-β-cyclodextrin and sodium silicate, the amount of hydroxypropyl-β-cyclodextrin is 1g, and the amount of sodium silicate is 5g.

[0083] The lubricant is talcum powder, and the amount used is 5g.

[0084] (2) The activator, disintegrant and corrosion inhibitor are placed in an oven at 50°C and baked for 24 hours. After cooling, the mixture is taken out and crushed with a pulverizer. The powder is sieved through a 100-mesh sieve to obtain a second mixture.

[0085] The activator is tartaric acid, and the dosage is 300g.

[0086] The disintegrant is a mixture of citric acid and sodium bicarbonate, with the amount of citric acid being 30 g and the amount of sodium bicarbonate being 100 g.

[0087] The corrosion inhibitor is a mixture of hydroxyethylidene diphosphonic acid and methylbenzotriazole sodium salt, the dosage of hydroxyethylidene diphosphonic acid is 1g, and the dosage of methylbenzotriazole sodium salt is 1.5g.

[0088] (3) The first mixture and the second mixture are mixed evenly and directly compressed into tablets to obtain chlorine dioxide tablets.

[0089] The entire preparation process is carried out at a temperature of 20°C to 30°C and a relative humidity of 20% to 40%.

[0090] Example 2

[0091] (1) Add a chlorine dioxide precursor, a corrosion inhibitor, a binder, a stabilizer and a lubricant into a pulverizer and grind the powder. Pass the powder through a 100-mesh sieve to obtain a first mixture.

[0092] The chlorine dioxide precursor is sodium chlorite, and the dosage is 300g.

[0093] The corrosion inhibitor is a mixture of azaphenyl ring polyaminocaproic acid and organic siloxane ketone, the amount of azaphenyl ring polyaminocaproic acid is 3g, and the amount of organic siloxane ketone is 2g.

[0094] The binder is a mixture of hydroxypropyl methylcellulose and polyethylene glycol, the amount of hydroxypropyl methylcellulose is 50g, and the amount of polyethylene glycol is 100g.

[0095] The stabilizer is a mixture of sodium hexametaphosphate and boron nitride, the amount of sodium hexametaphosphate is 10g, and the amount of boron nitride is 1g.

[0096] The lubricant is micro powder silica gel, and the amount used is 3g.

[0097] (2) The activator and disintegrant are placed in an oven at 60°C and baked for 12 hours. The mixture is then taken out and crushed using a pulverizer. The powder is passed through a 100-mesh sieve to obtain a second mixture.

[0098] The activator is a mixture of potassium dihydrogen phosphate and aluminum trichloride, the amount of potassium dihydrogen phosphate is 150g, and the amount of aluminum trichloride is 150g.

[0099] The disintegrant is a mixture of malic acid and sodium bicarbonate, with the amount of malic acid being 50 g and the amount of sodium bicarbonate being 100 g.

[0100] (3) The first mixture and the second mixture are mixed evenly and directly compressed into tablets to obtain chlorine dioxide tablets.

[0101] The entire preparation process is carried out at a temperature of 20°C to 30°C and a relative humidity of 20% to 40%.

[0102] Example 3

[0103] The difference between Example 3 and Example 1 is that only hydroxypropyl-β-cyclodextrin is used in an amount of 6 g to prepare chlorine dioxide tablets.

[0104] Example 4

[0105] The difference between Example 4 and Example 3 is that 1 g of hydroxypropyl-β-cyclodextrin is used to prepare the chlorine dioxide tablets.

[0106] Example 5

[0107] The difference between Example 5 and Example 3 is that 10 g of hydroxypropyl-β-cyclodextrin is used to prepare the chlorine dioxide tablets.

[0108] Example 6

[0109] The difference between Example 6 and Example 3 is that 4 g of hydroxypropyl-β-cyclodextrin is used to prepare the chlorine dioxide tablets.

[0110] Example 7

[0111] The difference between Example 6 and Example 3 is that 15 g of hydroxypropyl-β-cyclodextrin is used to prepare the chlorine dioxide tablets.

[0112] Example 8

[0113] The difference between Example 8 and Example 1 is that only sodium silicate is used, and the amount of sodium silicate used is 6g to prepare the chlorine dioxide tablet.

[0114] Example 9

[0115] The difference between Example 9 and Example 3 is that 6 g of magnesium sulfate, a conventional stabilizer in the art, is used to prepare the chlorine dioxide tablets.

[0116] Example 10

[0117] The difference between Example 10 and Example 1 is that only methylbenzotriazole sodium salt is used to prepare the chlorine dioxide tablet.

[0118] Embodiment 11

[0119] The difference between Example 11 and Example 10 is that 1 g of methylbenzotriazole sodium salt is used to prepare the chlorine dioxide tablet.

[0120] Example 12

[0121] The difference between Example 12 and Example 10 is that 5 g of methylbenzotriazole sodium salt is used to prepare the chlorine dioxide tablets.

[0122] Embodiment 13

[0123] The difference between Example 13 and Example 10 is that 2.5 g of sodium phosphate, a conventional corrosion inhibitor in the art, is used to prepare the chlorine dioxide tablets.

[0124] Embodiment 14

[0125] The difference between Example 14 and Example 1 is that only 2.5 g of hydroxyethylidene diphosphonic acid is used to prepare chlorine dioxide tablets.

[0126] Embodiment 15

[0127] The difference between Example 15 and Example 2 is that only sodium hexametaphosphate is used, and the amount of sodium hexametaphosphate used is 11 g to prepare chlorine dioxide tablets.

[0128] Example 16

[0129] The difference between Example 16 and Example 2 is that only boron nitride is used, and the amount of boron nitride used is 11g to prepare the chlorine dioxide tablet.

[0130] Embodiment 17

[0131] The difference between Example 17 and Example 2 is that only azaphenyl ring polyaminocaproic acid is used, and the amount of azaphenyl ring polyaminocaproic acid used is 5g to prepare chlorine dioxide tablets.

[0132] Embodiment 18

[0133] The difference between Example 18 and Example 2 is that only organic silicon oxalone is used, and the amount of organic silicon oxalone used is 5g to prepare the chlorine dioxide tablet.

[0134] Embodiment 19

[0135] The difference between Example 19 and Example 1 is that 0.1 g of hydroxypropyl-β-cyclodextrin and 5 g of sodium silicate are used to prepare chlorine dioxide tablets.

[0136] Embodiment 20

[0137] The difference between Example 20 and Example 1 is that 5 g of hydroxypropyl-β-cyclodextrin and 1 g of sodium silicate are used to prepare chlorine dioxide tablets.

[0138] Embodiment 21

[0139] The difference between Example 21 and Example 1 is that 0.1 g of hydroxyethylidene diphosphonic acid and 1.5 g of methylbenzotriazole sodium salt are used to prepare chlorine dioxide tablets.

[0140] Embodiment 22

[0141] The difference between Example 22 and Example 1 is that 1.5 g of hydroxyethylidene diphosphonic acid and 1 g of methylbenzotriazole sodium salt are used to prepare chlorine dioxide tablets.

[0142] Embodiment 23

[0143] The difference between Example 23 and Example 2 is that 1 g of sodium hexametaphosphate and 10 g of boron nitride are used to prepare chlorine dioxide tablets.

[0144] Embodiment 24

[0145] The difference between Example 24 and Example 2 is that 2 g of azaphenyl ring polyaminocaproic acid and 3 g of organosiloxane ketone are used to prepare chlorine dioxide tablets.

[0146] Comparative Example 1

[0147] (1) Add a chlorine dioxide precursor, a binder and a lubricant into a pulverizer and grind the powder. Pass the powder through a 100-mesh sieve to obtain a first mixture.

[0148] The chlorine dioxide precursor is sodium chlorite, and the dosage is 500g.

[0149] The adhesive is polyvinyl pyrrolidone K30, and the amount used is 80g.

[0150] The lubricant is talcum powder, and the amount used is 5g.

[0151] (2) The activator and disintegrant are placed in an oven at 50°C and baked for 24 hours. After cooling, the mixture is taken out and crushed using a pulverizer. The powder is passed through a 100-mesh sieve to obtain a second mixture.

[0152] The activator is tartaric acid, and the dosage is 300g.

[0153] The disintegrant is a mixture of citric acid and sodium bicarbonate, with the amount of citric acid being 30 g and the amount of sodium bicarbonate being 100 g.

[0154] (3) The first mixture and the second mixture are mixed evenly and directly compressed into tablets to obtain chlorine dioxide tablets.

[0155] The entire preparation process is carried out at a temperature of 20°C to 30°C and a relative humidity of 20% to 40%.

[0156] Comparative Example 2

[0157] (1) Add a chlorine dioxide precursor, a binder and a lubricant into a pulverizer and grind the powder. Pass the powder through a 100-mesh sieve to obtain a first mixture.

[0158] The chlorine dioxide precursor is sodium chlorite, and the dosage is 300g.

[0159] The binder is a mixture of hydroxypropyl methylcellulose and polyethylene glycol, the amount of hydroxypropyl methylcellulose is 50g, and the amount of polyethylene glycol is 100g.

[0160] The lubricant is micro powder silica gel, and the amount used is 3g.

[0161] (2) The activator and disintegrant are placed in an oven at 60°C and baked for 12 hours. The mixture is then taken out and crushed using a pulverizer. The powder is passed through a 100-mesh sieve to obtain a second mixture.

[0162] The activator is a mixture of potassium dihydrogen phosphate and aluminum trichloride, the amount of potassium dihydrogen phosphate is 150g, and the amount of aluminum trichloride is 150g.

[0163] The disintegrant is a mixture of malic acid and sodium bicarbonate, with the amount of malic acid being 50 g and the amount of sodium bicarbonate being 100 g.

[0164] (3) The first mixture and the second mixture are mixed evenly and directly compressed into tablets to obtain chlorine dioxide tablets.

[0165] The entire preparation process is carried out at a temperature of 20°C to 30°C and a relative humidity of 20% to 40%.

[0166] Table 1 ; .

[0167] Experimental example: Stability and metal corrosion test

[0168] 1 g of the chlorine dioxide tablets in Examples 1-12 and Comparative Examples 1-2 were respectively dissolved in 1 L of purified water, and 50-200 mg / L chlorine dioxide solution was obtained after activation. The stability and metal corrosion resistance of the solution were tested according to the methods in 2.2.3 and 2.2.4 of Technical Specifications for Disinfection (2002 Edition). The results are shown in Table 2.

[0169] Table 2 .

[0170] In summary, the composition described in the present application has a stabilizer and a corrosion inhibitor added thereto, and the stabilizer and the corrosion inhibitor are specific stabilizers and corrosion inhibitors. After activation, the stability of the prepared tablets is greatly improved, and the corrosion to metals is greatly reduced, which is conducive to the large-scale promotion and application of chlorine dioxide.

[0171] The above is only the preferred embodiment of the present application, and does not limit the present application in other forms. Any technician familiar with the profession may use the above disclosed technical content to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present application without departing from the technical solution of the present application still falls within the protection scope of the technical solution of the present application.

Claims

1. A composition containing chlorine dioxide, comprising a chlorine dioxide precursor, a stabilizer and a corrosion inhibitor; The stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride.

2. The composition according to claim 1, wherein The corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organic siloxane ketone.

3. The composition according to any one of claims 1 to 2, wherein The composition also includes an activator, a disintegrant, a binder and a lubricant.

4. The composition according to claim 3, wherein In terms of mass percentage in the composition, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

5. The composition according to claim 3, wherein The activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid; and / or The disintegrant comprises sodium bicarbonate and citric acid, or comprises sodium bicarbonate and malic acid; and / or The binder is selected from one or more of polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and polyethylene glycol; and / or The lubricant is selected from one or more of talc, magnesium stearate and micro powder silica gel.

6. The composition according to any one of claims 1-2, wherein the composition is in the form of a tablet.

7. A method for preparing a chlorine dioxide tablet, comprising: Mixing and grinding a chlorine dioxide precursor, a binder, a stabilizer and a lubricant to obtain a first mixture; Mixing and grinding the activator and the disintegrant to obtain a second mixture; The first mixture and the second mixture are mixed and tabletted to obtain chlorine dioxide tablets; The corrosion inhibitor is mixed and crushed with the chlorine dioxide precursor, the binder, the stabilizer and the lubricant to obtain a first mixture, or the corrosion inhibitor is mixed and crushed with the activator and the disintegrant to obtain a second mixture.

8. The method according to claim 7, wherein: In terms of mass percentage in the composition, the chlorine dioxide precursor is 30-50%, the activator is 20-30%, the disintegrant is 2-8%, the binder is 8-15%, the stabilizer is 0.1-1%, the corrosion inhibitor is 0.05-0.5%, and the lubricant is 0.1-0.5%.

9. The method according to claim 7 or 8, wherein: The activator is selected from one or more of citric acid, tartaric acid, sodium bisulfate, potassium dihydrogen phosphate, aluminum trichloride and phytic acid; and / or The disintegrant comprises sodium bicarbonate and citric acid, or comprises sodium bicarbonate and malic acid; and / or The binder is selected from one or more of polyvinyl pyrrolidone K30, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose and polyethylene glycol; and / or The lubricant is selected from one or more of talc, magnesium stearate and micro-powder silica gel; and / or The stabilizer is selected from one or more of hydroxypropyl-β-cyclodextrin, sodium hexametaphosphate, sodium silicate and boron nitride; and / or The corrosion inhibitor is selected from one or more of hydroxyethylidene diphosphonic acid, methylbenzotriazole sodium salt, azaphenyl ring polyaminocaproic acid, tetrasodium iminodisuccinate and organic siloxane ketone.