Medical nursing functional dressing for cleaning and nursing and preparation method thereof

Abstract

The invention relates to a medical nursing functional dressing for cleaning and nursing and a preparation method thereof, and belongs to the technical field of functional dressings, and the functional dressing comprises sodium alginate, glycerol, alkyl glycoside, methylparaben and purified water. The invention also provides a preparation method of the sodium alginate raw material, which comprises the following steps: S1, pretreatment: respectively pretreating kelp with pure water, absolute ethyl alcohol, diethyl ether and anhydrous acetone to obtain pretreated kelp; s2, compound enzyme treatment: firstly carrying out ultrasonic enzymolysis on the pretreated kelp by adopting cellulase and pectinase, and then carrying out ultrasonic enzymolysis by adopting alginate lyase, pullulanase and neutral protease to obtain a mixture C; s3, preparing sodium alginate: digesting, decolorizing, acidifying and dehydrating the mixture C to obtain the sodium alginate. The sodium alginate prepared by the invention is high in purity, and can be used as one of the raw materials of the functional dressing to achieve a synergistic effect with other raw materials, so that the prepared functional dressing has cleaning and nursing effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of functional dressings, and in particular, relates to a medical nursing functional dressing for cleaning and care and a preparation method thereof. Background Art

[0002] In modern life, people have an increasing demand for skin cleansing and care. As the largest organ of the human body, the skin often faces various challenges such as environmental pollution and ultraviolet radiation. These factors can easily lead to excessive secretion of skin oil and accumulation of dirt. They may also cause the skin to lose moisture, become dry and rough. Traditional medical care products can only focus on providing care functions, but lack cleaning effects. Therefore, there is an urgent need for a care product that can effectively clean and remove grease while providing hydrating care for the skin. Dressings, as a common skin care tool, have the advantages of good fit and ease of use.

[0003] Therefore, developing a nursing functional dressing that has both cleansing and moisturizing care effects will bring new options for people's skin care and has great practical significance. Summary of the invention

[0004] The purpose of the present invention is to provide a medical nursing functional dressing for cleaning and nursing and a preparation method thereof, so as to solve the problem that the nursing functional dressing in the prior art is difficult to have both cleaning and nursing functions.

[0005] The purpose of the present invention can be achieved through the following technical solutions:

[0006] A medical nursing functional dressing for cleaning and nursing, the functional dressing specifically comprises the following raw materials in parts by weight:

[0007]

[0008]

[0009] As a preferred technical solution of the present invention, the preparation method of sodium alginate comprises the following steps:

[0010] S1. Pretreatment: pretreating the kelp with pure water, anhydrous ethanol, ether and anhydrous acetone respectively to obtain pretreated kelp;

[0011] S2, compound enzyme treatment: the pretreated kelp is first subjected to ultrasonic enzymolysis using cellulase and pectinase, and then subjected to ultrasonic enzymolysis using alginate lyase, pullulanase and neutral protease to obtain a mixture C;

[0012] S3. Preparation of sodium alginate: digesting, decolorizing, acidifying and dehydrating the mixed material C to obtain sodium alginate.

[0013] As a preferred technical solution of the present invention, step S1 is specifically:

[0014] The kelp was cleaned by brushing in running water, and then rinsed with pure water. After the rinsing, the kelp was taken out, chopped, and refluxed in an anhydrous ethanol water bath. After the reflux was completed, it was first washed with anhydrous ethanol and then with ether, and dried. It was refluxed in an anhydrous acetone water bath. After the reflux was completed, it was washed with anhydrous ethanol, dried, crushed, and sieved to obtain the pretreated kelp.

[0015] Furthermore, the pure water washing time is 40-45 minutes; the temperature of the reflux temperature controlled by anhydrous ethanol water bath is 74-76°C, and the time is 3-3.5 hours; the number of washing times is 3-5 times; the temperature of the reflux temperature controlled by anhydrous acetone water bath is 54-55°C, and the time is 2.5-3 hours; the screening is through a 200-mesh sieve.

[0016] As a preferred technical solution of the present invention, step S2 is specifically:

[0017] The pretreated kelp and deionized water are uniformly mixed to obtain a mixture A, the pH of the mixture A is adjusted by temperature control, cellulase and pectinase are added, ultrasonic enzymolysis is performed, and a mixture B is obtained after enzymolysis, the pH of the mixture B is adjusted by temperature control, alginate lyase, pullulanase and neutral protease are added, ultrasonic enzymolysis is performed, and heating and boiling are performed to inactivate the enzyme activity to obtain a mixture C.

[0018] Furthermore, the dosage ratio of the pretreated kelp and deionized water is 1g:20-25mL; the mass ratio of the mixture A, cellulase and pectinase is 1:0.03-0.05:0.03-0.04; the mass ratio of the mixture B, alginate lyase, pullulanase and neutral protease is 1:0.03-0.04:0.02-0.03:0.04-0.05.

[0019] Furthermore, the enzymatic activity of the cellulase is 1×10 5 U / g, the enzyme activity of pectinase is 3×10 4 U / g, and the enzyme activity of the alginate lyase was 1.5×10 4 U / g, the enzyme activity of the pullulanase is 1×10 3 U / g, the enzyme activity of the neutral protease is 2×10 5 U / g.

[0020] Furthermore, the temperature for adjusting the pH of the mixture A by temperature control is 50-55°C, pH=4.5; the temperature for adjusting the pH of the mixture A by temperature control is 55-60°C, pH=6.5; the time for ultrasonic enzymolysis is 2-2.5h; the time for heating and boiling to inactivate enzyme activity is 10-12min.

[0021] Furthermore, in the temperature-controlled adjustment of the pH of the mixture A and the temperature-controlled adjustment of the pH of the mixture B, the regulators used are at least one of 0.01M phosphate buffer and 1 mol / L sodium hydroxide solution.

[0022] As a preferred technical solution of the present invention, step S3 is specifically:

[0023] Add sodium carbonate solution to mixed material C, control the temperature, seal and control the speed to stir and digest, add hydrogen peroxide after digestion and control the temperature for decolorization to obtain mixed material D, adjust the pH of mixed material D, add calcium chloride solution and let it stand, filter to obtain precipitate A and filtrate A, add hydrochloric acid solution to precipitate A to acidify it twice, filter again to obtain precipitate B and filtrate B, add sodium carbonate solution to precipitate B, dehydrate it with anhydrous ethanol, filter, take the precipitate and control the temperature to dry it to obtain sodium alginate.

[0024] Furthermore, the mass ratio of the mixture C, sodium carbonate solution and hydrogen peroxide is 1:15-16:1.5-2; the mass ratio of the mixture D and calcium chloride solution is 1:0.25-0.3; the mass ratio of the precipitate A and hydrochloric acid solution is 1:28-30; the mass ratio of the precipitate B, sodium carbonate solution and anhydrous ethanol is 1:14-16:15-18.

[0025] Furthermore, the concentration of the sodium carbonate solution is 0.1 mol / L; the mass concentration of the hydrogen peroxide is 0.2%; the concentration of the calcium chloride solution is 1 mol / L; and the concentration of the hydrochloric acid solution is 0.1 mol / L.

[0026] Furthermore, the temperature of the temperature-controlled sealing and speed-controlled is 55-60°C, the speed is 200-250r / min, and the time is 1-1.5h; the temperature of the temperature-controlled bleaching is 55-60°C, and the time is 1-1.5h; the pH of the mixed material D is adjusted by adding 1 mol / L sodium hydroxide solution to adjust the pH of the mixed material D to 6.0; the standing time is 0.5-1h; the acidification time is 0.5-1h each time; the temperature of the temperature-controlled drying is 50-55°C.

[0027] A method for preparing a medical nursing functional dressing for cleaning and nursing, specifically comprising the following steps:

[0028] Add sodium alginate, glycerin and methylparaben to purified water in sequence, stir at controlled speed and temperature, stir and cool after stirring, add alkyl polyglycoside, stir at controlled speed to obtain a functional dressing product.

[0029] As a preferred technical solution of the present invention, the temperature of the speed and temperature control is 80-90°C, the speed is 20-25r / min, and the time is 20-30min; the re-stirring and cooling is cooling to 35-45°C; the speed of the speed-controlled stirring is 20-25r / min, and the time is 10-15min.

[0030] Beneficial effects of the present invention:

[0031] (1) The formula of the present invention has simple ingredients and significant efficacy, and has both cleaning and care effects. Specifically, the added alkyl glycoside has good cleaning ability and solubility, good compatibility with the skin, and at the same time, it also has a moisturizing function, which can significantly improve the mildness of the formula and effectively remove dirt and grease on the skin surface; the added methylparaben can inhibit the growth of microorganisms and effectively help the system maintain excellent cleanliness; the added glycerol has an excellent moisturizing and water-locking effect, which can effectively relieve dry skin and replenish moisture for the skin; the added sodium alginate can form a protective film to prevent the evaporation of skin moisture and keep the skin moisturized for a long time; therefore, the alkyl glycoside, methylparaben, glycerol and sodium alginate added in the present invention can work synergistically from the different dimensions of cleaning, care, decontamination and grease removal, antibacterial, moisturizing and water-locking, so that the functional dressing product prepared has both cleaning and care effects.

[0032] (2) The present invention pre-treats the kelp and then performs enzymolysis treatment, so that the pre-treatment effectively removes the inherent impurities in the kelp and avoids the sodium alginate yield affected by the impurities; and in the enzymolysis treatment, the dissolution of useful substances in the cell wall is accelerated by adding a composite enzyme, which saves the amount of sodium carbonate solution used in the digestion process. At the same time, the composite enzymolysis can also improve the purity and quality of the finished alginate to a certain extent. Specifically, in the process of composite enzyme treatment, the present invention first breaks the cell wall of the kelp with a composite of cellulase and pectinase and cuts off the alginate macromolecules. On this basis, the composite is connected to obtain alginate lyase, pullulanase and neutral protease, and the alginate lyase is used as the extraction tool enzyme to accelerate the dissolution rate of sodium alginate in the system, and the protein macromolecules are degraded by pullulanase and neutral protease, thereby reducing the solution viscosity, which is convenient for further assisting the dissolution of sodium alginate. At the same time, the entire enzymolysis process is accompanied by ultrasound assistance, which greatly improves the leaching quality of sodium alginate.

[0033] (3) The digestion step of the present invention adopts sealed speed-controlled stirring digestion, i.e., simmering digestion, which strengthens the solid-liquid mass transfer effect, helps the sodium carbonate solution to quickly penetrate into the kelp body during the digestion process, greatly improves the digestion ability of the kelp, and makes the finished product have a high yield, high viscosity, and good purity. DETAILED DESCRIPTION

[0034] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] Example 1

[0036] A medical nursing functional dressing for cleaning and nursing, the functional dressing specifically comprises the following raw materials in parts by weight:

[0037]

[0038] The preparation method of sodium alginate comprises the following steps:

[0039] S1, pretreatment: clean the kelp in running water, then rinse with pure water for 40 minutes, take out the kelp after rinsing, chop it, reflux it in anhydrous ethanol water bath at 74°C for 3 hours, wash it with anhydrous ethanol and then with ether for 5 times respectively after reflux, dry it, reflux it in anhydrous acetone water bath at 54°C for 3 hours, wash it with anhydrous ethanol 5 times after reflux, dry it, crush it, and pass it through a 200-mesh sieve to obtain the pretreated kelp;

[0040] S2. Compound enzyme treatment: pretreated kelp and deionized water were mixed uniformly at a dosage ratio of 1 g: 20 mL to obtain mixture A, the pH of mixture A was adjusted to 4.5 at 52.5°C, cellulase and pectinase were added, and ultrasonic enzymolysis was performed for 2 h to obtain mixture B, the pH of mixture B was adjusted to 6.5 at 60°C, alginate lyase, pullulanase and neutral protease were added, ultrasonic enzymolysis was performed for 2 h, and the mixture was heated and boiled for 10 min to inactivate the enzyme activity to obtain mixture C;

[0041] In the temperature control to adjust the pH of the mixture A and the temperature control to adjust the pH of the mixture B, the regulator used is 0.01M phosphate buffer. When the phosphate buffer is difficult to adjust to the required pH, 1 mol / L sodium hydroxide solution is used to assist in the adjustment;

[0042] The mass ratio of the mixture A, cellulase and pectinase is 1:0.03:0.035; the mass ratio of the mixture B, alginate lyase, pullulanase and neutral protease is 1:0.03:0.03:0.045;

[0043] The enzyme activity of the cellulase is 1×10 5 U / g, the enzyme activity of pectinase is 3×10 4 U / g, and the enzyme activity of the alginate lyase was 1.5×10 4U / g, the enzyme activity of the pullulanase is 1×10 3 U / g, the enzyme activity of the neutral protease is 2×10 5 U / g;

[0044] S3, preparation of sodium alginate: add 0.1mol / L sodium carbonate solution to mixture C, control the temperature to 55℃, seal and control the speed to 200r / min, stir and digest for 1h, add 0.2% hydrogen peroxide after digestion, control the temperature to 57.5℃ for decolorization for 1.5h, obtain mixture D, add 1mol / L sodium hydroxide solution to adjust the pH of mixture D to 6.0, add 1mol / L calcium chloride solution and let stand for 0.5h, filter to obtain precipitate A and filtrate A, add 0.1mol / L hydrochloric acid solution to precipitate A for acidification twice, each time for 0.5h, filter again to obtain precipitate B and filtrate B, add 0.1mol / L sodium carbonate solution to precipitate B, dehydrate with anhydrous ethanol, filter, take the precipitate and control the temperature to 52.5℃ for drying to obtain sodium alginate;

[0045] The mass ratio of the mixture C, sodium carbonate solution and hydrogen peroxide is 1:15:1.5; the mass ratio of the mixture D and calcium chloride solution is 1:0.25; the mass ratio of the precipitate A and hydrochloric acid solution is 1:29; the mass ratio of the precipitate B, sodium carbonate solution and anhydrous ethanol is 1:14:15.

[0046] The preparation method of the functional dressing specifically comprises the following steps:

[0047] The sodium alginate, glycerin and methylparaben prepared above were added to the purified water in turn, and the stirring was carried out at a speed of 20 r / min and a temperature of 80°C for 20 min. After the stirring was completed, the temperature was cooled to 35°C by stirring, and the alkyl glycoside was added. The stirring was carried out at a speed of 25 r / min for 12.5 min to obtain the functional dressing product.

[0048] After testing, the purity of the sodium alginate prepared in this embodiment is 98.8%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this embodiment is 45.9%, and the viscosity is 2.59 Pa·s.

[0049] Example 2

[0050] A medical nursing functional dressing for cleaning and nursing, the functional dressing specifically comprises the following raw materials in parts by weight:

[0051]

[0052] The preparation method of sodium alginate comprises the following steps:

[0053] S1, pretreatment: clean the kelp in running water, then rinse with pure water for 45 minutes, take out the kelp after rinsing, chop it, reflux it in anhydrous ethanol water bath at 75°C for 3 hours, wash it with anhydrous ethanol and then with ether for 3 times, dry it, reflux it at 54.5°C in anhydrous acetone water bath for 2.5 hours, wash it with anhydrous ethanol 3 times after reflux, dry it, crush it, and pass it through a 200-mesh sieve to obtain the pretreated kelp;

[0054] S2. Compound enzyme treatment: pretreated kelp and deionized water were mixed uniformly at a dosage ratio of 1 g: 22.5 mL to obtain mixture A, the pH value of mixture A was adjusted to 4.5 at 50°C, cellulase and pectinase were added, and ultrasonic enzymolysis was performed for 2 h to obtain mixture B, the pH value of mixture B was adjusted to 6.5 at 57.5°C, alginate lyase, pullulanase and neutral protease were added, ultrasonic enzymolysis was performed for 2 h, and the mixture was heated and boiled for 11 min to inactivate the enzyme activity to obtain mixture C;

[0055] In the temperature control to adjust the pH of the mixture A and the temperature control to adjust the pH of the mixture B, the regulator used is 0.01M phosphate buffer. When the phosphate buffer is difficult to adjust to the required pH, 1 mol / L sodium hydroxide solution is used to assist in the adjustment;

[0056] The mass ratio of the mixture A, cellulase and pectinase is 1:0.05:0.03; the mass ratio of the mixture B, alginate lyase, pullulanase and neutral protease is 1:0.035:0.025:0.05;

[0057] The enzyme activity of the cellulase is 1×10 5 U / g, the enzyme activity of pectinase is 3×10 4 U / g, and the enzyme activity of the alginate lyase was 1.5×10 4 U / g, the enzyme activity of the pullulanase is 1×10 3 U / g, the enzyme activity of the neutral protease is 2×10 5 U / g;

[0058] S3, preparation of sodium alginate: add 0.1mol / L sodium carbonate solution to mixed material C, control the temperature to 57.5℃, seal and control the speed to 225r / min, stir and digest for 1.5h, add 0.2% hydrogen peroxide and control the temperature to 55℃ for decolorization for 1h after digestion to obtain mixed material D, add 1mol / L sodium hydroxide solution to adjust the pH of mixed material D to 6.0, then add 1mol / L calcium chloride solution and let stand for 1h, filter to obtain precipitate A and filtrate A, add 0.1mol / L hydrochloric acid solution to precipitate A for acidification twice, each time for 1h, filter again to obtain precipitate B and filtrate B, add 0.1mol / L sodium carbonate solution to precipitate B, dehydrate with anhydrous ethanol, filter, take the precipitate and control the temperature to 50℃ for drying to obtain sodium alginate;

[0059] The mass ratio of the mixture C, sodium carbonate solution and hydrogen peroxide is 1:15.5:1.7; the mass ratio of the mixture D and calcium chloride solution is 1:0.28; the mass ratio of the precipitate A and hydrochloric acid solution is 1:28; the mass ratio of the precipitate B, sodium carbonate solution and anhydrous ethanol is 1:15:17.5.

[0060] The preparation method of the functional dressing specifically comprises the following steps:

[0061] The sodium alginate, glycerin and methylparaben prepared above were added to the purified water in turn, and the stirring was carried out at a speed of 25 r / min and a temperature of 85°C for 25 min. After the stirring was completed, the temperature was cooled to 45°C by stirring, and the alkyl glycoside was added. The stirring was carried out at a speed of 22.5 r / min and 10 min to obtain the functional dressing product.

[0062] After testing, the purity of the sodium alginate prepared in this embodiment is 98.9%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this embodiment is 46.2%, and the viscosity is 2.62 Pa·s.

[0063] Example 3

[0064] A medical nursing functional dressing for cleaning and nursing, the functional dressing specifically comprises the following raw materials in parts by weight:

[0065]

[0066] The preparation method of sodium alginate comprises the following steps:

[0067] S1, pretreatment: scrub the kelp in running water, then rinse with pure water for 43 minutes, take out the kelp after rinsing, chop it, reflux it in an absolute ethanol water bath at 76°C for 3.5 hours, wash it with an absolute ethanol and then with ether for 4 times respectively after reflux, dry it, reflux it at 55°C in an absolute acetone water bath for 2.5 hours, wash it with an absolute ethanol for 4 times after reflux, dry it, crush it, and pass it through a 200-mesh sieve to obtain the pretreated kelp;

[0068] S2. Compound enzyme treatment: pretreated kelp and deionized water were mixed uniformly at a dosage ratio of 1 g: 25 mL to obtain mixture A, the pH value of mixture A was adjusted to 4.5 at 55°C, cellulase and pectinase were added, and ultrasonic enzymolysis was performed for 2.5 h to obtain mixture B, the pH value of mixture B was adjusted to 6.5 at 55°C, alginate lyase, pullulanase and neutral protease were added, ultrasonic enzymolysis was performed for 2.5 h, and the mixture was heated and boiled for 12 min to inactivate the enzyme activity to obtain mixture C;

[0069] In the temperature control to adjust the pH of the mixture A and the temperature control to adjust the pH of the mixture B, the regulator used is 0.01M phosphate buffer. When the phosphate buffer is difficult to adjust to the required pH, 1 mol / L sodium hydroxide solution is used to assist in the adjustment;

[0070] The mass ratio of the mixture A, cellulase and pectinase is 1:0.04:0.04; the mass ratio of the mixture B, alginate lyase, pullulanase and neutral protease is 1:0.04:0.02:0.04;

[0071] The enzyme activity of the cellulase is 1×10 5 U / g, the enzyme activity of pectinase is 3×10 4 U / g, and the enzyme activity of the alginate lyase was 1.5×10 4 U / g, the enzyme activity of the pullulanase is 1×10 3 U / g, the enzyme activity of the neutral protease is 2×10 5 U / g;

[0072] S3, preparation of sodium alginate: add 0.1mol / L sodium carbonate solution to mixed material C, control the temperature at 60℃, seal and control the speed at 250r / min, stir and digest for 1h, add 0.2% hydrogen peroxide and control the temperature at 60℃ for decolorization for 1h after digestion to obtain mixed material D, add 1mol / L sodium hydroxide solution to adjust the pH of mixed material D to 6.0, then add 1mol / L calcium chloride solution and let stand for 1h, filter to obtain precipitate A and filtrate A, add 0.1mol / L hydrochloric acid solution to acidify precipitate A twice, each time for h, filter again to obtain precipitate B and filtrate B, add 0.1mol / L sodium carbonate solution to precipitate B, dehydrate with anhydrous ethanol, filter, take the precipitate and control the temperature at 55℃ to dry to obtain sodium alginate;

[0073] The mass ratio of the mixture C, sodium carbonate solution and hydrogen peroxide is 1:16:2; the mass ratio of the mixture D and calcium chloride solution is 1:0.3; the mass ratio of the precipitate A and hydrochloric acid solution is 1:30; the mass ratio of the precipitate B, sodium carbonate solution and anhydrous ethanol is 1:16:18.

[0074] The preparation method of the functional dressing specifically comprises the following steps:

[0075] The sodium alginate, glycerin and methylparaben prepared above were added to the purified water in turn, and the stirring was carried out at a speed of 22.5 r / min and a temperature of 90°C for 30 min. After the stirring was completed, the temperature was cooled to 40°C by stirring, and the alkyl glycoside was added. The stirring was carried out at a speed of 20 r / min for 15 min to obtain the functional dressing product.

[0076] After testing, the purity of the sodium alginate prepared in this embodiment is 99.1%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this embodiment is 46.4%, and the viscosity is 2.64 Pa·s.

[0077] Comparative Example 1

[0078] Compared with Example 3, the difference is that in Comparative Example 1, the original step S1 is replaced by:

[0079] S1. Pretreatment: clean the kelp in running water, then rinse with pure water for 43 minutes. After the rinsing is completed, take out the kelp, crush it, and pass it through a 200-mesh sieve to obtain the pretreated kelp;

[0080] The remaining operation steps and parameters remain unchanged.

[0081] After testing, the purity of the sodium alginate prepared in this comparative example is 96.1%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 43.3%, and the viscosity is 2.01 Pa·s.

[0082] Comparative Example 2

[0083] Compared with Example 3, the difference is that in step S2 of Comparative Example 2, no cellulase is added, and the usage ratio of the mixture A and pectinase is 1:0.08; the other operating steps and parameters remain unchanged.

[0084] After testing, the purity of the sodium alginate prepared in this comparative example is 90.7%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 39.3%, and the viscosity is 1.67 Pa·s.

[0085] Comparative Example 3

[0086] Compared with Example 3, the difference is that in step S2 of Comparative Example 3, pectinase is not added, and the usage ratio of the mixture A and cellulase is 1:0.08; the other operating steps and parameters remain unchanged.

[0087] After testing, the purity of the sodium alginate prepared in this comparative example is 91.9%; according to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 40.2%, and the viscosity is 1.71 Pa·s.

[0088] Comparative Example 4

[0089] Compared with Example 3, the difference is that in step S2 of Comparative Example 4, no cellulase and pectinase are added, that is, alginate lyase, pullulanase and neutral protease are directly used for ultrasonic enzymatic hydrolysis; the other operating steps and parameters remain unchanged.

[0090] After testing, the purity of the sodium alginate prepared in this comparative example is 82.6%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 32.5%, and the viscosity is 1.06 Pa·s.

[0091] Comparative Example 5

[0092] Compared with Example 3, the difference is that in step S2 of Comparative Example 5, no alginate lyase is added, and the usage ratio of the mixture B, pullulanase and neutral protease is 1:0.04:0.06; the other operating steps and parameters remain unchanged.

[0093] After testing, the purity of the sodium alginate prepared in this comparative example is 93.0%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 41.5%, and the viscosity is 1.80 Pa·s.

[0094] Comparative Example 6

[0095] Compared with Example 3, the difference is that in step S2 of Comparative Example 6, pullulanase is not added, and the usage ratio of the mixture B, alginate lyase and neutral protease is 1:0.05:0.05; the other operating steps and parameters remain unchanged.

[0096] After testing, the purity of the sodium alginate prepared in this comparative example is 93.8%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 42.2%, and the viscosity is 1.88 Pa·s.

[0097] Comparative Example 7

[0098] Compared with Example 3, the difference is that in step S2 of Comparative Example 7, no neutral protease is added, and the usage ratio of the mixture B, alginate lyase and pullulanase is 1:0.06:0.04; the other operating steps and parameters remain unchanged.

[0099] After testing, the purity of the sodium alginate prepared in this comparative example is 94.6%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 42.7%, and the viscosity is 1.94 Pa·s.

[0100] Comparative Example 8

[0101] Compared with Example 3, the difference is that in step S2 of Comparative Example 8, no alginate lyase, pullulanase and neutral protease are added, that is, cellulase and pectinase are directly used for ultrasonic enzymolysis; the other operating steps and parameters remain unchanged.

[0102] After testing, the purity of the sodium alginate prepared in this comparative example is 85.9%. According to GB1976-80, the extraction rate of the sodium alginate prepared in this comparative example is 34.6%, and the viscosity is 1.35 Pa·s.

[0103] Comparative Example 9

[0104] Compared with Example 3, the difference is that in Comparative Example 9, commercially available sodium alginate is used to replace the sodium alginate prepared in Example 3; the other operating steps and parameters remain unchanged.

[0105] Comparative Example 10

[0106] Compared with Example 3, the difference is that in Comparative Example 10, the prepared sodium alginate is not added, but glycerol is 5.26 parts by weight, and alkyl glycoside and methylparaben are both 0.33 parts by weight; the other operating steps and parameters remain unchanged.

[0107] Comparative Example 11

[0108] Compared with Example 3, the difference is that in Comparative Example 11, no glycerol is added, and the prepared sodium alginate is 2.46 parts by weight, and the alkyl glycoside and methylparaben are both 1.73 parts by weight; the other operating steps and parameters remain unchanged.

[0109] Comparative Example 12

[0110] Compared with Example 3, the difference is that in Comparative Example 12, no alkyl glycoside is added, and the prepared sodium alginate is 0.82 parts by weight, glycerol is 5.02 parts by weight, and methylparaben is 0.08 parts by weight; the other operating steps and parameters remain unchanged.

[0111] Comparative Example 13

[0112] Compared with Example 3, the difference is that in Comparative Example 13, no methylparaben is added, and the prepared sodium alginate is 0.82 parts by weight, glycerol is 5.02 parts by weight, and alkyl glycoside is 0.08 parts by weight; the other operating steps and parameters remain unchanged.

[0113] Test Case

[0114] 96 volunteers, half of whom were male and half were female, aged 25-55, were randomly divided into 8 groups with 12 people in each group. After washing their faces with clean water, the functional dressing products prepared in Examples 1-3 and Comparative Examples 9-13 were evenly applied on the washed faces, with a coating thickness of 0.5 mm. Half an hour after coating, the volunteers scored the degree of facial oiliness and skin hydration after coating, and the scoring was marked as follows:

[0115] Compared with before use, there is no obvious greasy feeling, the face is not dry, and the moisturizing effect is obvious, 5 points;

[0116] Compared with before use, it still feels slightly greasy, the face is slightly dry, and the moisturizing effect is poor, 3 points;

[0117] Compared with before use, the greasy feeling is very little different, the face is dry, and the moisturizing effect is poor, 1 point.

[0118] The final score of each group was the group average, and the results are shown in Table 1.

[0119] Table 1

[0120] Rating (points) Example 1 4.67 Example 2 4.83 Example 3 4.83 Comparative Example 9 4 Comparative Example 10 2.67 Comparative Example 11 3 Comparative Example 12 3.5 Comparative Example 13 3.67

[0121] It can be seen from Table 1 that the functional dressing product prepared by the present invention has both cleaning and care effects.

[0122] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0123] The above contents are merely examples and explanations of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the invention or exceed the scope defined by the claims, they shall all fall within the protection scope of the present invention.

Claims

1. A medical nursing functional dressing for cleaning and nursing, characterized in that: The functional dressing specifically comprises the following raw materials in parts by weight:

2. The medical nursing functional dressing for cleaning and nursing according to claim 1, characterized in that: The preparation method of sodium alginate comprises the following steps: S1. Pretreatment: pretreating the kelp with pure water, anhydrous ethanol, ether and anhydrous acetone respectively to obtain pretreated kelp; S2, compound enzyme treatment: the pretreated kelp is first subjected to ultrasonic enzymolysis using cellulase and pectinase, and then subjected to ultrasonic enzymolysis using alginate lyase, pullulanase and neutral protease to obtain a mixture C; S3. Preparation of sodium alginate: digesting, decolorizing, acidifying and dehydrating the mixed material C to obtain sodium alginate.

3. The medical nursing functional dressing for cleaning and nursing according to claim 2, characterized in that: Step S1 is specifically as follows: clean the kelp by brushing it in running water, then rinse it with pure water, take out the kelp after the rinsing is completed, chop it, and reflux it in an anhydrous ethanol water bath. After the reflux is completed, wash it with anhydrous ethanol and then with ether respectively, dry it, reflux it in an anhydrous acetone water bath, wash it with anhydrous ethanol after the reflux is completed, dry it, crush it, and sieve it to obtain the pretreated kelp.

4. The medical nursing functional dressing for cleaning and nursing according to claim 2, characterized in that: Step S2 is specifically as follows: the pretreated kelp and deionized water are mixed evenly to obtain a mixture A, the pH of the mixture A is adjusted by temperature control, cellulase and pectinase are added, ultrasonic enzymolysis is performed, and a mixture B is obtained after enzymolysis, the pH of the mixture B is adjusted by temperature control, alginate lyase, pullulanase and neutral protease are added, ultrasonic enzymolysis is performed, and heating and boiling are performed to inactivate the enzyme activity to obtain a mixture C.

5. The medical nursing functional dressing for cleaning and nursing according to claim 4, characterized in that: The dosage ratio of the pretreated kelp and deionized water is 1g:20-25mL; the mass ratio of the mixture A, cellulase and pectinase is 1:0.03-0.05:0.03-0.04; the mass ratio of the mixture B, alginate lyase, pullulanase and neutral protease is 1:0.03-0.04:0.02-0.03:0.04-0.

05.

6. The medical nursing functional dressing for cleaning and nursing according to claim 2, characterized in that: Step S3 is specifically as follows: Add sodium carbonate solution to mixed material C, control the temperature, seal and control the speed to stir and digest, add hydrogen peroxide after digestion and control the temperature for decolorization to obtain mixed material D, adjust the pH of mixed material D, add calcium chloride solution and let it stand, filter to obtain precipitate A and filtrate A, add hydrochloric acid solution to precipitate A to acidify it twice, filter again to obtain precipitate B and filtrate B, add sodium carbonate solution to precipitate B, dehydrate it with anhydrous ethanol, filter, take the precipitate and control the temperature to dry it to obtain sodium alginate.

7. The medical nursing functional dressing for cleaning and nursing according to claim 6, characterized in that: The mass ratio of the mixture C, sodium carbonate solution and hydrogen peroxide is 1:15-16:1.5-2; the mass ratio of the mixture D and calcium chloride solution is 1:0.25-0.3; the mass ratio of the precipitate A and hydrochloric acid solution is 1:28-30; the mass ratio of the precipitate B, sodium carbonate solution and anhydrous ethanol is 1:14-16:15-18.

8. The medical nursing functional dressing for cleaning and nursing according to claim 6, characterized in that: The temperature of the temperature-controlled sealing and speed-controlled process is 55-60°C, the speed is 200-250r / min, and the time is 1-1.5h; the temperature of the temperature-controlled decolorization is 55-60°C, and the time is 1-1.5h; the pH of the mixed material D is adjusted by adding 1mol / L sodium hydroxide solution to adjust the pH of the mixed material D to 6.0; the standing time is 0.5-1h; the acidification time is 0.5-1h each time; the temperature of the temperature-controlled drying is 50-55°C.

9. A method for preparing the cleaning and nursing medical nursing functional dressing according to any one of claims 1 to 8, characterized in that: The specific steps include: Add sodium alginate, glycerin and methylparaben to purified water in sequence, stir at controlled speed and temperature, stir and cool after stirring, add alkyl polyglycoside, stir at controlled speed to obtain a functional dressing product.

10. The method for preparing the cleaning and nursing medical nursing functional dressing according to claim 9, characterized in that: The temperature of the speed control and temperature control is 80-90°C, the speed is 20-25r / min, and the time is 20-30min; the re-stirring and cooling is cooling to 35-45°C; the speed of the speed control and stirring is 20-25r / min, and the time is 10-15min.

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