Medicine with effects of warming and invigorating kidney yang, generating essence and nourishing blood and preparation method thereof

Abstract

The invention relates to the technical field of biological medicine, in particular to a medicine with the effects of warming and invigorating kidney yang, generating essence and nourishing blood and a preparation method of the medicine, and every 1 L of the medicine comprises the following raw materials by mass: 9-11 g of cornu cervi pantotrichum, 200-900 g of honey, 5-15 g of sodium citrate, 0.5-3 g of citric acid and the balance of water. The pH (Potential of Hydrogen) value of the medicine is 5.0 to 5.7. By limiting the pH value of the medicine to 5.0-5.7, the stability of the medicine can be improved, and the risk of precipitation can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of biomedicine, and in particular to a medicine having the functions of warming and tonifying kidney yang, producing essence and nourishing blood, and a preparation method thereof. Background Art

[0002] Deer antlers come from the young horns of male deer (Cervus nippon) or red deer (Cervus elaphus) that are not ossified and accompanied by fine hairs during growth. They are a good medicine for warming the kidney yang, producing essence and nourishing blood, and have extremely high medicinal value. Deer antlers are composed of cartilage or bone and attached skin, blood vessels, nerves, etc., and are the only mammalian organ known to be able to regenerate completely. "Suwen" records that "kidneys are the root of storage and the place where essence is stored, and they are filled in bones." Modern studies have also found that the growth and development of bones are closely related to kidney essence-brain marrow-bone marrow. Modern pharmacology has found that the main active ingredients of deer antlers are deer antler polypeptides, deer antler polysaccharides, deer antler polyamines, proteins, amino acids, sex hormones and fat-soluble components.

[0003] At present, deer antler is usually prepared into oral liquid to achieve the effect of warming and nourishing kidney yang, producing essence and nourishing blood. The oral liquid made from deer antler contains active ingredients in the deer antler concentrate, and also contains some high molecular impurity components. These components are highly soluble when heated and gradually precipitate after cooling, or the oral liquid precipitates due to changes in the type of solvent, temperature, oxidation, pH value, etc. The deer antler oral liquid prepared by the existing technology has poor stability and is prone to precipitation during storage. The precipitation of the oral liquid will not only reduce the content of the active ingredients, but also affect the effectiveness and stability of the oral liquid. On the other hand, it will make consumers mistakenly believe that the product is deteriorating, affecting the patient's psychology.

[0004] Therefore, how to improve the stability of pilose antler oral liquid and reduce the risk of precipitation is a technical problem to be solved urgently in this field. Summary of the invention

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, and a preparation method thereof. The present invention can improve the stability of the medicine and reduce the risk of precipitation by limiting the pH value of the medicine to 5.0-5.7.

[0006] In order to achieve the above object, the present invention adopts the following technical solutions:

[0007] In a first aspect, the present invention provides a medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, wherein each 1L of the medicine comprises the following raw materials of the following mass:

[0008]

[0009] The pH value of the drug is 5.0-5.7.

[0010] Further, the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood is an oral liquid having the effects of warming and tonifying kidney yang, producing essence and nourishing blood;

[0011] and / or, taking water as a reference substance, the relative density of the drug is not less than 1.16;

[0012] And / or, each 1L of the drug further includes the following raw materials:

[0013] Flavor 0.1~1g.

[0014] Furthermore, the flavor includes at least one of strawberry flavor, orange flavor, pineapple flavor, apple flavor, mint flavor, lemon flavor, chocolate flavor, and grape flavor.

[0015] Furthermore, each 1L of the drug also includes the following raw materials:

[0016] 3-6 g of metal ion compound;

[0017] Wherein, the metal ions in the metal ion compound include at least one of zinc ions and magnesium ions.

[0018] Furthermore, the metal ion compound is a metal ion salt, and the anions forming the metal ion salt include at least one of acetate, carbonate, chloride, nitrate, nitrite, phosphate, sulfate, and borate.

[0019] In a second aspect, the present invention provides a method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood as described in the first aspect, the preparation method comprising the following steps:

[0020] S1, preparing a pilose antler extract concentrate, adding water to the pilose antler extract concentrate for dilution and filtering to obtain a first filtrate;

[0021] S2, weighing the sodium citrate and honey in the formula amount, dissolving the sodium citrate in water to obtain an aqueous solution of sodium citrate, adding the aqueous solution of sodium citrate to the honey, stirring and heating, and filtering while hot to obtain a second filtrate;

[0022] S3, adding the first filtrate obtained in step S1 to the second filtrate, stirring, then adding water to make up the volume, and then adding the citric acid to adjust the pH value of the drug to 5.0-5.7, filling, sterilizing, and obtaining.

[0023] Further, in step S3, after the stirring is completed, a formula amount of essence is added to the second filtrate after cooling;

[0024] and / or, in step S1, after the filtration, adding a formulated amount of an aqueous solution of the metal ion compound to the filtrate to obtain a first filtrate;

[0025] And / or, the preparation method of the pilose antler extract concentrate comprises the following steps:

[0026] S11, slicing the antler, then vacuum freeze-drying the antler slices, crushing the vacuum freeze-dried antler to obtain antler powder, and adding the antler powder to an extraction tank;

[0027] S12, adding 50% to 80% ethanol solution in an amount of 2 to 10 times the weight of the velvet antler powder to the extraction tank, and reflux extraction for 2 to 6 hours;

[0028] S13, repeating step S12 2-6 times, taking the supernatant each time, combining the supernatants after reflux extraction 2-6 times, concentrating, and concentrating the antler extract until the mass ratio of the extract to the antler powder is 1:1;

[0029] S14, inputting the concentrated antler extract in step S13 into an alcohol precipitation tank, adding 95% ethanol solution in an amount of 5-12 times the weight of the concentrated antler extract, stirring evenly, standing for 24-36 hours, taking the supernatant, recovering ethanol until there is no alcohol taste, and concentrating until the mass ratio of the extract to the antler powder is (0.6-0.8):1, to obtain the antler extract concentrate.

[0030] Furthermore, in step S11, the vacuum freeze drying temperature is -55 to -65°C, and the vacuum freeze drying time is 12 to 48 hours;

[0031] And / or, in step S13, the concentration pressure is controlled at 0.1-0.2 MPa, the concentration temperature is controlled at 60-80° C., and the concentration vacuum is controlled at -0.06--0.08 MPa;

[0032] And / or, in step S14, the concentration pressure is controlled at 0.1-0.2 MPa, the concentration temperature is controlled at 60-80° C., and the concentration vacuum degree is controlled at -0.06--0.08 MPa.

[0033] Furthermore, in step S1, the mass ratio of the velvet antler powder to the solution diluted with water is (60-70):100;

[0034] and / or, in step S2, the mass ratio of the sodium citrate to the water is 1:(4-6);

[0035] And / or, in step S2, the heating temperature is 90-100° C., and the heating time is 10-30 minutes;

[0036] And / or, in step S3, the sterilization temperature is 115° C. and the sterilization time is 1800 seconds;

[0037] And / or, in step S3, filtering is performed using a filter membrane after the volume is fixed, wherein the pore size of the filter membrane is 1.0 μm.

[0038] Furthermore, in step S3, the flavor is added in the form of an alcohol solution of the flavor, and the preparation method of the alcohol solution of the flavor includes: weighing a formula amount of the flavor, adding an ethanol solution with a volume percentage of 50% to 95% to the flavor, to obtain an alcohol solution of the flavor, wherein the mass ratio of the flavor to the ethanol solution is 1:(3 to 10).

[0039] Compared with the prior art, the beneficial effects of the present invention include at least one of the following:

[0040] (1) The present invention can improve the stability of the drug and reduce the risk of precipitation by limiting the pH value of the drug to 5.0-5.7.

[0041] (2) The present invention limits the raw materials of the drug to include metal ion compounds, so that the active ingredients in the velvet antler can form chelates with the metal ions. The spatial chelation between the active ingredients and the metal ions is utilized to stabilize the spatial structure of the active ingredients, thereby improving the spatial stability of the compound, thereby further improving the stability of the drug and reducing the risk of precipitation. DETAILED DESCRIPTION

[0042] In order to make the purpose, technical scheme and advantages of the present invention clearer, the technical scheme in the embodiment of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present invention. The process parameters of the following embodiments that do not specify specific conditions are usually based on conventional conditions.

[0043] The endpoints and any values ​​of the ranges disclosed in the present invention are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of each range, the endpoint values ​​of each range and the individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be regarded as specifically disclosed in the present invention.

[0044] In a first aspect, the present invention provides a medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, wherein each 1L of the medicine comprises the following raw materials of the following mass:

[0045]

[0046] The pH value of the drug is 5.0-5.7.

[0047] The present invention can improve the stability of the drug and reduce the risk of precipitation by limiting the pH value of the drug to 5.0-5.7.

[0048] Among the above-mentioned medicines having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation manner, the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood is an oral liquid (deer antler oral liquid) having the effects of warming and tonifying kidney yang, producing essence and nourishing blood.

[0049] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation manner, taking water as a reference substance, the relative density of the medicine is not less than 1.16.

[0050] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation manner, taking water as a reference substance, the relative density of the medicine is 1.16 to 1.20.

[0051] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation, each 1L of the medicine further includes the following raw materials of mass:

[0052] 0.1-1g of flavor (for example, 0.1g, 0.3g, 0.5g, 0.7g or 1g).

[0053] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation manner, the flavor includes at least one of strawberry flavor, orange flavor, pineapple flavor, apple flavor, mint flavor, lemon flavor, chocolate flavor, and grape flavor.

[0054] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation, each 1L of the medicine further includes the following raw materials of mass:

[0055] 3-6 g of metal ion compound;

[0056] Wherein, the metal ions in the metal ion compound include at least one of zinc ions and magnesium ions.

[0057] In the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional embodiment, the metal ion compound is a metal ion salt, and the anions forming the metal ion salt include at least one of acetate, carbonate, chloride, nitrate, nitrite, phosphate, sulfate and borate.

[0058] In a second aspect, the present invention provides a method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood as described in the first aspect, the preparation method comprising the following steps:

[0059] S1, preparing a pilose antler extract concentrate, adding water to the pilose antler extract concentrate for dilution and filtering to obtain a first filtrate;

[0060] S2, weighing the sodium citrate and honey in the formula amount, dissolving the sodium citrate in water to obtain an aqueous solution of sodium citrate, adding the aqueous solution of sodium citrate to the honey, stirring and heating, and filtering while hot to obtain a second filtrate;

[0061] S3, adding the first filtrate obtained in step S1 to the second filtrate, stirring, then adding water to make up the volume, and then adding the citric acid to adjust the pH value of the drug to 5.0-5.7, filling, sterilizing, and obtaining.

[0062] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood comprises the following steps: in step S3, after the stirring is completed, a formulated amount of essence is added to the second filtrate after cooling.

[0063] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood comprises, in step S1, adding a formulated amount of an aqueous solution of the metal ion compound to the filtrate after the filtration to obtain a first filtrate.

[0064] The preparation method of the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation, the preparation method of the velvet antler extract concentrate comprises the following steps:

[0065] S11, slicing the antler, then vacuum freeze-drying the antler slices, crushing the vacuum freeze-dried antler to obtain antler powder, and adding the antler powder to an extraction tank;

[0066] S12, adding 50% to 80% (for example, 50%, 60%, 70% or 80%) ethanol solution in an amount 2 to 10 times the weight of the velvet antler powder to the extraction tank, and reflux extraction for 2 to 6 hours;

[0067] S13, repeating step S12 2-6 times, taking the supernatant each time, combining the supernatants after reflux extraction 2-6 times, concentrating, and concentrating the antler extract until the mass ratio of the extract to the medicinal material (antler powder) is 1:1 (the mass ratio of the concentrated antler extract to the antler powder is 1:1);

[0068] S14, inputting the concentrated antler extract in step S13 into an alcohol precipitation tank, adding 95% ethanol solution in an amount of 5-12 times the weight of the concentrated antler extract, stirring evenly, standing for 24-36 hours, taking the supernatant, recovering ethanol until there is no alcohol taste, and concentrating until the mass ratio of the extract to the medicinal material (antler powder) is (0.6-0.8):1, to obtain the antler extract concentrate.

[0069] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, in step S11, the temperature of the vacuum freeze-drying is -55 to -65°C, and the time of the vacuum freeze-drying is 12 to 48 hours.

[0070] The preparation method of the above-mentioned medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation mode, in step S13, the concentration pressure is controlled at 0.1~0.2MPa, the concentration temperature is controlled at 60~80℃ (for example, it can be 60℃, 65℃, 70℃, 75℃ or 80℃), and the concentration vacuum degree is controlled at -0.06~-0.08Mpa.

[0071] The preparation method of the above-mentioned medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation mode, in step S14, the concentration pressure is controlled at 0.1~0.2MPa, the concentration temperature is controlled at 60~80℃ (for example, it can be 60℃, 65℃, 70℃, 75℃ or 80℃), and the concentration vacuum degree is controlled at -0.06~-0.08Mpa.

[0072] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, in step S1, the mass ratio of the velvet antler powder to the solution after dilution with water is (60-70):100.

[0073] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, in step S2, the mass ratio of the sodium citrate to the water is 1:(4-6).

[0074] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, in step S2, the heating temperature is 90-100° C., and the heating time is 10-30 minutes.

[0075] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, in step S3, the sterilization temperature is 115° C. and the sterilization time is 1800 seconds (30 minutes).

[0076] The method for preparing the above-mentioned medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood, as an optional implementation manner, in step S3, the essence is added in the form of an alcohol solution of the essence, and the method for preparing the alcohol solution of the essence comprises: weighing a formula amount of the essence, adding an ethanol solution with a volume percentage of 50% to 95% (for example, 50%, 60%, 70% or 95%) to the essence, to obtain an alcohol solution of the essence, wherein the mass ratio of the essence to the ethanol solution is 1:(3 to 10).

[0077] As an optional implementation, the method for preparing the above-mentioned medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood comprises the following steps: in step S3, filtering is performed using a filter membrane after volume is fixed, wherein the pore size of the filter membrane is 1.0 μm.

[0078] The present invention will be further described in detail below with reference to specific embodiments and comparative examples.

[0079] Example 1

[0080] This embodiment provides a medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of oral liquid with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid includes the following raw materials of the following quality:

[0081]

[0082] The pH value of the oral liquid is 5.3 and the relative density is 1.18.

[0083] The preparation method of the oral liquid provided in this embodiment comprises the following steps:

[0084] S1, slicing 120 kg of velvet antler (without fur), and then freeze-drying the velvet antler slices at -55°C for 24 hours, breaking the velvet antler after vacuum freeze-drying to obtain velvet antler powder, and adding the velvet antler powder into an extraction tank;

[0085] The method comprises the following steps: adding 50% ethanol solution by volume in an amount of 10 times the weight of the antler powder into the extraction tank, opening the steam valve, heating the liquid to boil, starting the timing for 2 hours, closing the steam valve after the extraction, filtering the extract through a double filter (100 meshes), and pumping the extract into a storage tank; repeating the reflux extraction for 5 times, taking the supernatant each time, combining the supernatants after reflux extraction for 5 times, pumping the supernatants into a concentrator, opening the steam valve, controlling the pressure at 0.1 MPa, the concentration temperature at 80°C, the vacuum at -0.08 MPa, starting the concentration, and concentrating the antler extract to 120 kg;

[0086] The concentrated antler extract is input into an alcohol precipitation tank, and then an ethanol solution with a volume percentage of 95% is added in an amount 10 times the weight of the concentrated antler extract, stirred for 30 minutes, and allowed to stand for 24 hours, and the supernatant is taken, and the steam valve is opened, and the pressure is controlled at 0.1MPa, the concentration temperature is controlled at 80°C, and the vacuum degree is controlled at -0.08Mpa, and concentration is started, and ethanol is recovered until there is no alcohol taste. The antler extract is concentrated to 72kg to obtain a antler extract concentrate;

[0087] Dissolve 60 kg of zinc sulfate in an appropriate amount of water to obtain an aqueous solution of zinc sulfate;

[0088] Add water to the velvet antler extract concentrate to dilute it to 200 kg, filter it, collect the filtrate, add an aqueous solution of zinc sulfate to the filtrate, stir it evenly, and obtain a first filtrate;

[0089] S2, add 8400kg of honey to a preparation tank, warm (45°C); take 120kg of sodium citrate, add 600kg of purified water to dissolve, and obtain an aqueous solution of sodium citrate; add the aqueous solution of sodium citrate (dissolved sodium citrate) to the honey, stir well, heat to 100°C, keep for 20 minutes, filter through a 100-mesh filter cloth while hot into another preparation tank, rinse the residual honey with rinse water, continue filtering, combine the filtrate, and obtain a second filtrate;

[0090] S3, adding the first filtrate obtained in step S1 to the second filtrate under stirring, and stirring evenly; taking 1.8 kg of strawberry essence, adding 9 kg of 95% ethanol by volume to dilute while stirring; when the temperature of the liquid medicine is cooled to below 60° C., adding the strawberry essence diluent, and then adding purified water, the volume is fixed to 12000 L, stirring for 30 minutes, filtering into another liquid preparation tank, the filter membrane pore size is: 1.0 μm, and the preparation and filtration are completed within 5 hours; adding 24 kg of citric acid to the filtrate to adjust the pH value to 5.3, potting, sterilization, and the sterilization temperature is 115° C. and the sterilization time is 1800 seconds.

[0091] Example 2

[0092] This embodiment provides a medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of oral liquid with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid includes the following raw materials of the following quality:

[0093]

[0094] The pH value of the oral liquid is 5.5 and the relative density is 1.17.

[0095] The preparation method of the oral liquid provided in this embodiment comprises the following steps:

[0096] S1, slicing 120 kg of velvet antler (without fur), and then freeze-drying the velvet antler slices at -60°C for 36 hours, breaking the velvet antler after vacuum freeze-drying to obtain velvet antler powder, and adding the velvet antler powder into an extraction tank;

[0097] The method comprises the following steps: adding 60% ethanol solution by volume in an amount of 10 times the weight of the antler powder into the extraction tank, opening the steam valve, heating the liquid to boil, starting the timing for 2 hours, closing the steam valve after the extraction, filtering the extract through a double filter (100 meshes), and injecting the extract into a storage tank; repeating the reflux extraction for 5 times, taking the supernatant each time, combining the supernatants after reflux extraction for 5 times, injecting the supernatants into a concentrator, opening the steam valve, controlling the pressure at 0.1 MPa, the concentration temperature at 80°C, the vacuum degree at -0.08 MPa, starting the concentration, and concentrating the antler extract to 120 kg;

[0098] The concentrated antler extract was input into an alcohol precipitation tank, and then an ethanol solution with a volume percentage of 95% was added in an amount 10 times the weight of the concentrated antler extract, and stirred for 30 minutes, and then allowed to stand for 36 hours, and the supernatant was taken, and the steam valve was opened, and the pressure was controlled at 0.1MPa, the concentration temperature was controlled at 80°C, and the vacuum degree was controlled at -0.08Mpa, and concentration was started, and ethanol was recovered until there was no alcohol taste. The antler extract was concentrated to 84kg to obtain a antler extract concentrate;

[0099] Dissolve 60 kg of zinc sulfate in an appropriate amount of water to obtain an aqueous solution of zinc sulfate;

[0100] Add water to the velvet antler extract concentrate to dilute it to 200 kg, filter it, collect the filtrate, add an aqueous solution of zinc sulfate to the filtrate, stir it evenly, and obtain a first filtrate;

[0101] S2, add 6000kg of honey to a preparation tank, warm (45°C); take 120kg of sodium citrate, add 480kg of purified water to dissolve it, and obtain an aqueous solution of sodium citrate; add the aqueous solution of sodium citrate (dissolved sodium citrate) to the honey, stir well, heat to 100°C, keep for 20 minutes, filter with a 100-mesh filter cloth while hot into another preparation tank, rinse the residual honey with rinse water, continue filtering, combine the filtrate, and obtain a second filtrate;

[0102] S3. Add the first filtrate obtained in step S1 to the second filtrate under stirring and stir evenly; take 1.8 kg of lemon essence, add 9 kg of 95% ethanol by volume to dilute while stirring; when the temperature of the liquid medicine cools to below 60°C, add the lemon essence diluent, then add purified water, fix the volume to 12000 L, stir for 30 minutes, filter into another liquid preparation tank, the filter membrane pore size is: 1.0 μm, and the preparation and filtration are completed within 5 hours; add 20 kg of citric acid to the filtrate to adjust the pH value to 5.5, potting, sterilization, and the sterilization temperature is 115°C and the sterilization time is 1800 seconds.

[0103] Example 3

[0104] This embodiment provides a medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of oral liquid with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid includes the following raw materials of the following quality:

[0105]

[0106]

[0107] The pH value of the oral liquid is 5.0 and the relative density is 1.18.

[0108] The preparation method of the oral liquid provided in this embodiment comprises the following steps:

[0109] S1, slicing 120 kg of velvet antler (without fur), and then freeze-drying the velvet antler slices at -55°C for 24 hours, breaking the velvet antler after vacuum freeze-drying to obtain velvet antler powder, and adding the velvet antler powder into an extraction tank;

[0110] The method comprises the following steps: adding 50% ethanol solution by volume in an amount of 10 times the weight of the antler powder into the extraction tank, opening the steam valve, heating the liquid to boil, starting the timing for 2 hours, closing the steam valve after the extraction, filtering the extract through a double filter (100 meshes), and pumping the extract into a storage tank; repeating the reflux extraction for 5 times, taking the supernatant each time, combining the supernatants after reflux extraction for 5 times, pumping the supernatants into a concentrator, opening the steam valve, controlling the pressure at 0.1 MPa, the concentration temperature at 80°C, the vacuum at -0.08 MPa, starting the concentration, and concentrating the antler extract to 120 kg;

[0111] The concentrated antler extract is input into an alcohol precipitation tank, and then an ethanol solution with a volume percentage of 95% is added in an amount 10 times the weight of the concentrated antler extract, stirred for 30 minutes, and allowed to stand for 24 hours, and the supernatant is taken, and the steam valve is opened, and the pressure is controlled at 0.1MPa, the concentration temperature is controlled at 80°C, and the vacuum degree is controlled at -0.08Mpa, and concentration is started, and ethanol is recovered until there is no alcohol taste. The antler extract is concentrated to 72kg to obtain a antler extract concentrate;

[0112] Dissolve 60 kg of zinc sulfate in an appropriate amount of water to obtain an aqueous solution of zinc sulfate;

[0113] Add water to the velvet antler extract concentrate to dilute it to 200 kg, filter it, collect the filtrate, add an aqueous solution of zinc sulfate to the filtrate, stir it evenly, and obtain a first filtrate;

[0114] S2, add 9600kg of honey to a preparation tank, warm (45°C); take 120kg of sodium citrate, add 600kg of purified water to dissolve, and obtain an aqueous solution of sodium citrate; add the aqueous solution of sodium citrate (dissolved sodium citrate) to the honey, stir well, heat to 100°C, keep for 20 minutes, filter with a 100-mesh filter cloth while hot into another preparation tank, rinse the residual honey with rinse water, continue filtering, combine the filtrate, and obtain a second filtrate;

[0115] S3. Add the first filtrate obtained in step S1 to the second filtrate under stirring and mix well; take 1.8 kg of apple essence, add 9 kg of 95% ethanol by volume to dilute while stirring; when the temperature of the liquid medicine cools to below 60° C., add the apple essence diluent, then add purified water, fix the volume to 12000 L, stir for 30 minutes, filter into another liquid preparation tank, the filter membrane pore size is 1.0 μm, and the preparation and filtration are completed within 5 hours; add 28 kg of citric acid to the filtrate to adjust the pH value to 5.0, potting, sterilization, and the sterilization temperature is 115° C. and the sterilization time is 1800 seconds.

[0116] Comparative Example 1

[0117] This comparative example provides a medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of an oral liquid with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid is basically the same as Example 1, except that the amount of citric acid is adjusted to a pH value of 4.5 for the oral liquid.

[0118] The oral liquid provided in this comparative example was prepared by referring to the preparation method provided in Example 1.

[0119] Comparative Example 2

[0120] This comparative example provides a medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of an oral liquid having the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid is basically the same as Example 1, except that the amount of citric acid is adjusted to a pH value of 6.5 for the oral liquid.

[0121] The oral liquid provided in this comparative example was prepared by referring to the preparation method provided in Example 1.

[0122] Comparative Example 3

[0123] This comparative example provides a medicine with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The medicine is 12000L of oral liquid with the effects of warming and tonifying kidney yang, producing essence and nourishing blood. The oral liquid is basically the same as Example 1, except that the raw materials of the oral liquid do not include zinc sulfate.

[0124] The oral liquid provided in this comparative example was prepared by referring to the preparation method provided in Example 1.

[0125] Performance Testing

[0126] The oral liquids provided in the examples and comparative examples were placed under accelerated test conditions (temperature 40°C / humidity 75%), and samples were taken for testing in January, February, March and June, respectively. The test results are shown in Table 1.

[0127]

[0128] From Table 1 we can at least see that:

[0129] (1) By comparing Examples 1-3 with Comparative Examples 1 and 2, it can be seen that the present invention can improve the stability of the drug and reduce the risk of precipitation by limiting the pH value of the drug to 5.0-5.7.

[0130] (2) By comparing Examples 1-3 with Comparative Example 3, it can be seen that the present invention can further improve the stability of the oral liquid and reduce the risk of precipitation by adding metal ions to the oral liquid. The reason may be that the active ingredients in the deer antler oral liquid can form chelates with metal ions, and the active ingredients and metal ions form spatial chelation to stabilize the spatial structure of the active ingredients, improve the spatial stability of the compound, and thus improve the stability of the deer antler oral liquid.

[0131] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood, characterized in that: Each 1L of the drug contains the following raw materials: The pH value of the drug is 5.0-5.

7.

2. The medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 1, characterized in that: The medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood is an oral liquid having the effects of warming and tonifying kidney yang, producing essence and nourishing blood; and / or, taking water as a reference substance, the relative density of the drug is not less than 1.16; And / or, each 1L of the drug further includes the following raw materials: Flavor 0.1~1g.

3. The medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 2, characterized in that: The flavor includes at least one of strawberry flavor, orange flavor, pineapple flavor, apple flavor, mint flavor, lemon flavor, chocolate flavor, and grape flavor.

4. The medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 1, characterized in that: Each 1L of the drug also includes the following raw materials: 3-6 g of metal ion compound; Wherein, the metal ions in the metal ion compound include at least one of zinc ions and magnesium ions.

5. The medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 4, characterized in that: The metal ion compound is a metal ion salt, and the anions forming the metal ion salt include at least one of acetate, carbonate, chloride, nitrate, nitrite, phosphate, sulfate and borate.

6. A method for preparing a medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood as claimed in any one of claims 1 to 5, characterized in that: The preparation method comprises the following steps: S1, preparing a pilose antler extract concentrate, adding water to the pilose antler extract concentrate for dilution and filtering to obtain a first filtrate; S2, weighing the sodium citrate and honey in the formula amount, dissolving the sodium citrate in water to obtain an aqueous solution of sodium citrate, adding the aqueous solution of sodium citrate to the honey, stirring and heating, and filtering while hot to obtain a second filtrate; S3, adding the first filtrate obtained in step S1 to the second filtrate, stirring, then adding water to make up the volume, and then adding the citric acid to adjust the pH value of the drug to 5.0-5.7, filling, sterilizing, and obtaining.

7. The method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 6, characterized in that: In step S3, after the stirring is completed, a formula amount of essence is added to the second filtrate after cooling; and / or, in step S1, after the filtration, adding a formulated amount of an aqueous solution of the metal ion compound to the filtrate to obtain a first filtrate; And / or, the preparation method of the velvet antler extract concentrate comprises the following steps: S11, slicing the antler, then vacuum freeze-drying the antler slices, crushing the vacuum freeze-dried antler to obtain antler powder, and adding the antler powder to an extraction tank; S12, adding 50% to 80% ethanol solution in an amount of 2 to 10 times the weight of the velvet antler powder to the extraction tank, and reflux extraction for 2 to 6 hours; S13, repeating step S12 2-6 times, taking the supernatant each time, combining the supernatants after reflux extraction 2-6 times, concentrating, and concentrating the antler extract until the mass ratio of the extract to the antler powder is 1:1; S14, inputting the concentrated antler extract in step S13 into an alcohol precipitation tank, adding 95% ethanol solution in an amount of 5-12 times the weight of the concentrated antler extract, stirring evenly, standing for 24-36 hours, taking the supernatant, recovering ethanol until there is no alcohol taste, and concentrating until the mass ratio of the extract to the antler powder is (0.6-0.8):1, to obtain the antler extract concentrate.

8. The method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 7, characterized in that: In step S11, the vacuum freeze drying temperature is -55 to -65°C, and the vacuum freeze drying time is 12 to 48 hours; And / or, in step S13, the concentration pressure is controlled at 0.1-0.2 MPa, the concentration temperature is controlled at 60-80° C., and the concentration vacuum is controlled at -0.06--0.08 MPa; And / or, in step S14, the concentration pressure is controlled at 0.1-0.2 MPa, the concentration temperature is controlled at 60-80° C., and the concentration vacuum degree is controlled at -0.06--0.08 MPa.

9. The method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 6, characterized in that: In step S1, the mass ratio of the velvet antler powder to the solution diluted with water is (60-70):100; and / or, in step S2, the mass ratio of the sodium citrate to the water is 1:(4-6); And / or, in step S2, the heating temperature is 90-100° C., and the heating time is 10-30 minutes; And / or, in step S3, the sterilization temperature is 115° C. and the sterilization time is 1800 seconds; And / or, in step S3, filtering is performed using a filter membrane after the volume is fixed, wherein the pore size of the filter membrane is 1.0 μm.

10. The method for preparing the medicine having the effects of warming and tonifying kidney yang, producing essence and nourishing blood according to claim 7, characterized in that: In step S3, the flavor is added in the form of an alcohol solution of the flavor. The preparation method of the alcohol solution of the flavor includes: weighing a formula amount of the flavor, adding an ethanol solution with a volume percentage of 50% to 95% to the flavor, to obtain an alcohol solution of the flavor, wherein the mass ratio of the flavor to the ethanol solution is 1:(3 to 10).

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