Liquid medicine for treating tinea of feet and hands and preparation method thereof

Abstract

The invention discloses a liquid medicine for treating tinea manus and pedis and a preparation method thereof. The liquid medicine for treating tinea of feet and hands is prepared from the following raw materials in parts by weight: 6-8 parts of urea, 30-40 parts of white vinegar with acidity greater than 9 degrees, 6-8 parts of borneol, 5-9 parts of parachlorometaxylenol, 5-9 parts of dried alum, 12-16 parts of cortex dictamni, 8-10 parts of fructus kochiae, 6-8 parts of clove, 10-12 parts of fructus cnidii, 3-6 parts of radix sophorae flavescentis, 2-4 parts of pepper, 1-3 parts of rumex madaio, 2-4 parts of radix angelicae pubescentis, 4-7 parts of cortex phellodendri, 7-9 parts of cortex pseudolaricis and 6-9 parts of a skin penetrant. The preparation method of the liquid medicine for treating tinea manus and pedis comprises the following steps: respectively extracting each medicinal material by adopting an extracting agent, and respectively concentrating various obtained extracting solutions. The tinea manus and pedis treatment liquid medicine can effectively kill tinea manus and pedis pathogenic bacteria, the treatment process is efficient, and the recurrence rate of tinea manus and pedis can be reduced.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceuticals, in particular to a medicinal solution for treating tinea manuum and pedis and a preparation method thereof. Background Art

[0002] Tinea pedis is a common and frequently occurring disease, which often occurs on the palms, soles, between the fingers and between the soles. It is mainly caused by mold, Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton floccosum. Papules, papulovesicles, dry cracks and peeling often appear in the site of tinea pedis. In summer, tinea pedis and hand are also prone to induce eczema, bacterial infection or cause erysipelas, cellulite and other damage. Tinea pedis and hand have a high incidence rate, are difficult to cure, and have a long course. Patients may even be pathogenic bacteria for life, and are prone to relapse and difficult to eradicate.

[0003] Most of the drugs currently sold on the market for treating tinea pedis and tinea manuum have the effects of relieving itching, antibacterial and anti-inflammatory, but it is difficult to eradicate pathogenic bacteria. Chinese invention patent CN102224975B discloses a soaking liquid for treating tinea pedis and tinea manuum, which can effectively kill the pathogenic bacteria of tinea pedis and tinea manuum. On the basis of this patent, combined with patient feedback from clinical applications, the composition and preparation method of the liquid are further improved, and it is expected to obtain a more effective liquid for treating tinea pedis and tinea manuum. Summary of the invention

[0004] Therefore, the technical problem to be solved by the present invention is to provide a tinea pedis treatment liquid and a preparation method thereof. The tinea pedis treatment liquid provided in the present invention can effectively kill the pathogenic bacteria of tinea pedis, the treatment process is efficient, and the recurrence rate of tinea pedis can be reduced.

[0005] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0006] A tinea pedis treatment liquid, the raw materials used to prepare the tinea pedis treatment liquid include the following substances in parts by weight:

[0007] 6-8 parts of urea, 30-40 parts of white vinegar with acidity>9°, 6-8 parts of borneol, 5-9 parts of parachlorometaxylenol, 5-9 parts of alum, 12-16 parts of white ringworm peels, 8-10 parts of Kochia scoparia, 6-8 parts of cloves, 10-12 parts of Cnidium monnieri, 3-6 parts of Sophora flavescens, 2-4 parts of Zanthoxylum bungeanum, 1-3 parts of Rheum officinale, 2-4 parts of Angelica dahurica, 4-7 parts of Phellodendron amurense, 7-9 parts of Radix Sophorae Flavescentis, and 6-9 parts of skin penetrant.

[0008] The tinea manuum and pedis treatment liquid of the present invention has remarkable uniqueness and innovation in the selection of ingredients and proportion matching. The precise proportions between these ingredients effectively play a synergistic role. The combination of urea and white vinegar can not only soften the stratum corneum, but also has a strong antibacterial effect; the combination of parachlorometaxylenol and alum can significantly enhance the bactericidal effect and reduce the survival rate of pathogenic bacteria; and Chinese medicinal ingredients such as white ringworm peel, Kochia scoparia, and cloves have excellent effects in anti-inflammatory and antipruritic aspects. In addition, the addition of skin penetrants such as azone or dimethyl sulfoxide improves the penetration ability of the liquid, ensures that the active ingredients can act on the affected area at a deeper level, thereby improving the overall therapeutic effect. Through fine ingredient proportions and scientific preparation methods, the tinea manuum and pedis treatment liquid of the present invention shows efficient therapeutic effects in clinical applications, and the recurrence rate is low, reflecting its unique advantages in the treatment of tinea manuum and pedis.

[0009] A method for preparing a medicinal solution for treating tinea pedis and tinea manuum comprises the following steps:

[0010] (1) using an extractant to extract each medicinal material separately, and obtaining a plurality of extracts after filtering;

[0011] (2) concentrating the multiple extracts obtained in step (1) respectively to obtain multiple concentrated solutions;

[0012] (3) mixing urea, white vinegar with an acidity of more than 9°, borneol, parachlorometaxylenol, a skin penetrant, alum and the concentrated solution obtained in step (2) and stirring them uniformly to obtain a liquid medicine for treating tinea pedis and tinea manuum;

[0013] The medicinal materials in step (1) are respectively as follows by weight: 12-16 parts of white ringworm peels, 8-10 parts of Kochia scoparia, 6-8 parts of cloves, 10-12 parts of Cnidium monnieri, 3-6 parts of Sophora flavescens, 2-4 parts of Zanthoxylum bungeanum, 1-3 parts of Rheum officinale, 2-4 parts of Angelica dahurica, 4-7 parts of Phellodendron amurense, and 7-9 parts of Radix Sophorae flavescentis;

[0014] In step (3), the amounts of urea, white vinegar with an acidity of >9°, borneol, parachlorometaxylenol, skin penetrant and alum used are respectively: 6 to 8 parts of urea, 30 to 40 parts of white vinegar with an acidity of >9°, 6 to 8 parts of borneol, 5 to 9 parts of parachlorometaxylenol, 6 to 9 parts of skin penetrant and 5 to 9 parts of alum, by weight.

[0015] In the above-mentioned method for preparing the medicinal solution for treating tinea pedis and tinea manuum, in step (1), the extractant used is water, and the extraction method is a steaming method.

[0016] In the above-mentioned method for preparing the medicinal solution for treating tinea pedis, in step (1), when extracting the medicinal materials, the pressure in the extraction device is 0.1 MPa; when extracting each medicinal material separately, the volume / weight ratio of the extractant to the medicinal material is 10:1 mL / g.

[0017] In the preparation method of the above-mentioned tinea pedis rehabilitation liquid, in step (1), the extraction temperature of white ringworm peel is 60-80°C, the extraction temperature of Kochia scoparia is 70-80°C, the extraction temperature of clove is 70-80°C, the extraction temperature of Cnidium monnieri is 60-80°C, the extraction temperature of Sophora flavescens is 70-80°C, the extraction temperature of Zanthoxylum bungeanum is 70-80°C, the extraction temperature of Rheum officinale is 70-80°C, the extraction temperature of Angelica dahurica is 70-80°C, the extraction temperature of Phellodendron chinense is room temperature, and the extraction temperature of Rhizoma Cyperi is 70-80°C.

[0018] In the above-mentioned method for preparing the liquid medicine for treating tinea pedis and tinea manuum, in step (2), a vacuum rotary evaporator is used for concentration, the vacuum degree during concentration is 0.05-0.08Mpa, and the rotation speed is 100-200rpm; for any extract of medicinal materials, the volume of the concentrated liquid formed after concentration is 1 / 5 of the volume of the extract. The concentration is carried out under low pressure and the temperature is lower than that during extraction, which effectively retains the volatile oil and polysaccharide substances in the medicinal materials and avoids the degradation of the effective ingredients and the decline of the drug effect caused by high temperature.

[0019] In the method for preparing the above-mentioned liquid for treating tinea pedis and tinea manuum, in step (2), the rotary evaporation temperature of the extract of white ringworm skin is 50-55°C, the rotary evaporation temperature of the extract of Kochia scoparia is 45-50°C, the rotary evaporation temperature of the extract of Clove is 45-50°C, the rotary evaporation temperature of the extract of Cnidium monnieri is 55-60°C, the rotary evaporation temperature of the extract of Sophora flavescens is 50-55°C, the rotary evaporation temperature of the extract of Zanthoxylum bungeanum is 45-50°C, the rotary evaporation temperature of the extract of Rheum officinale is 55-60°C, the rotary evaporation temperature of the extract of Angelica dahurica is 50-55°C, the rotary evaporation temperature of the extract of Phellodendron chinense is 25-35°C, and the rotary evaporation temperature of the extract of Rhizoma Cyperi is 50-55°C. In the process of preparing the extract, by extending the extraction time in exchange for the temperature reduction during the steaming and extraction, the damage of the heat-sensitive components in the medicinal materials by high temperature is effectively avoided, ensuring that the active components in the medicinal materials are retained to the maximum extent.

[0020] The preparation method of the above-mentioned tinea pedis treatment convalescent solution, in step (3), the amounts of urea, white vinegar, borneol, parachloro-meta-xylenol, skin permeation agent and alum used are respectively: 8 parts of urea, 40 parts of white vinegar, 8 parts of borneol, 9 parts of parachloro-meta-xylenol, 9 parts of skin permeation agent, and 9 parts of alum by weight. Volatile substances such as borneol and white vinegar are added after concentration and stirred at a relatively low temperature, which is conducive to preventing the loss of their effective ingredients. The addition of azone or dimethyl sulfoxide not only improves the permeability of the liquid medicine, but also enhances the absorption efficiency of the effective ingredients of the body's medicinal materials, thereby further improving the overall therapeutic effect of the liquid medicine.

[0021] In the above method for preparing the medicinal solution for treating tinea pedis and tinea manuum, in step (3), the skin penetrant used is azone or dimethyl sulfoxide.

[0022] In the above-mentioned method for preparing the medicinal solution for treating tinea pedis and tinea manuum, in step (3), stirring is carried out under normal pressure; the temperature during stirring is less than or equal to 60° C., and the stirring time is 0.5 to 1.0 h.

[0023] The technical solution of the present invention achieves the following beneficial technical effects:

[0024] 1. The tinea pedis treatment liquid provided in the present invention increases the types of drugs, and through the methods of separate extraction and concentration, the effective ingredients in the medicinal materials are retained as much as possible, thereby improving the treatment effect. Clinical experiments show that the total effective rate of the tinea pedis treatment liquid prepared in the present invention reaches 100%, and the cure rate is not less than 78%.

[0025] 2. The tinea manuum and pedis treatment liquid of the present invention has remarkable uniqueness and innovation in the selection of ingredients and proportion matching. The precise proportions between these ingredients effectively play a synergistic role. The combination of urea and white vinegar can not only soften the stratum corneum, but also has a strong antibacterial effect; the combination of parachlorometaxylenol and alum can significantly enhance the bactericidal effect and reduce the survival rate of pathogenic bacteria; and Chinese medicinal ingredients such as white ringworm peel, Kochia scoparia, and cloves have excellent effects in anti-inflammatory and antipruritic aspects. In addition, the addition of skin penetrants such as azone or dimethyl sulfoxide improves the penetration ability of the liquid, ensuring that the active ingredients can act on the affected area at a deeper level, thereby improving the overall therapeutic effect.

[0026] 3. In the present invention, when preparing the treatment solution for tinea pedis and tinea manuum, various medicinal materials are extracted separately, and the extracts are concentrated separately. By extracting and concentrating separately, the most suitable extraction or concentration conditions, such as temperature, time and pressure, can be selected according to the characteristics of each medicinal material, thereby avoiding the destruction of heat-sensitive components by high temperature or inappropriate conditions, and avoiding the reaction of various components in the medicinal materials during mixed extraction or concentration, ensuring the maximum retention of active ingredients in the medicinal materials. And because the conditions of each step can be precisely controlled by extracting and concentrating separately, this method helps to improve the consistency and quality stability of the medicinal solution between batches, ensuring that each batch of medicinal solution has the same efficient therapeutic effect.

[0027] 4. The tinea pedis treatment liquid provided in the present invention is easy to use. When using the liquid to treat tinea pedis, it is only necessary to soak the affected part in the liquid, or wear gloves or socks soaked in the liquid, and each treatment lasts 50 to 60 minutes. In addition, the raw materials are easily available, the pharmaceutical process is simple, and the overall production cost is low, making this treatment method not only effective but also economical and has broad application prospects. DETAILED DESCRIPTION

[0028] Example 1

[0029] The tinea pedis treatment liquid prepared in this embodiment is made of the following medicinal materials by weight:

[0030] 15 kg of white ringworm peel, 9 kg of Kochia scoparia, 7 kg of cloves, 11 kg of Cnidium monnieri, 5 kg of Sophora flavescens, 3 kg of Zanthoxylum bungeanum, 2 kg of Rheum officinale, 3 kg of Angelica dahurica, 6 kg of Phellodendron amurense, and 8 kg of Sophora japonica bark.

[0031] In addition to the above-mentioned medicinal materials, urea, white vinegar, borneol, parachlorometaxylenol, skin penetrant and alum are also used in the preparation of the tinea pedis treatment liquid, and the amounts used are: 8 kg of urea, 40 kg of white vinegar, 8 kg of borneol, 9 kg of parachlorometaxylenol, 9 kg of skin penetrant and 9 kg of alum. Among them, the acidity of the white vinegar used is greater than 9°.

[0032] In this embodiment, the skin penetrant used is azone. In some other embodiments, the skin penetrant can be any one of azone and dimethyl sulfoxide.

[0033] Prepare the tinea pedis treatment solution as follows:

[0034] (1) Using water as the extractant, each medicinal material is subjected to steaming extraction by the steaming method (i.e., the medicinal material is placed in the extractant for steaming), and a variety of extracts are obtained (depending on the medicinal material, there are 10 types of extracts). During extraction, the extraction temperature and extraction time are determined according to the characteristics of different medicinal materials (the extraction time can be adjusted according to actual conditions). The air pressure in the extraction device is 0.1Mpa. When each medicinal material is subjected to steaming extraction, the volume / weight ratio of water to medicinal material is 10:1mL / g.

[0035] Table 1 shows the recommended extraction temperature and time for each herbal extract. During extraction, it is important to note that the fluctuations in temperature and time should not exceed the recommended range.

[0036] Table 1

[0037] Name of medicinal material Recommended extraction temperature (℃) Recommended extraction time (minutes) White ringworm skin 60～80 90～120 Kochia scoparia 70～80 90～120 clove 70～80 100～150 Cnidium monnieri 60～80 90～120 Sophora flavescens 70～80 90～120 Sichuan peppercorn 70～80 70～90 Rhubarb 70～80 90～120 Angelica dahurica 70～80 90～120 Cork Room temperature 40～60 Tushinpi 70～80 90～120

[0038] (2) The various extracts obtained in step (1) are concentrated respectively to obtain various concentrated solutions (there are 10 types of concentrated solutions); a vacuum rotary evaporator is used for concentration, and the vacuum degree during concentration is 0.06 MPa and the rotation speed is 150 rpm; for any extract of medicinal materials, it is concentrated to 1 / 5 of the volume of the extract. Table 2 shows the recommended rotary evaporation temperature for the concentration of extracts of various medicinal materials. During rotary evaporation, the temperature can be adjusted as long as it does not exceed the recommended rotary evaporation temperature range.

[0039] Table 2

[0040]

[0041] In some other embodiments, the conditions during concentration can also be adjusted according to actual conditions, but the vacuum degree is preferably 0.05-0.08 MPa, and the rotation speed is preferably 100-200 rpm.

[0042] (3) Mix and stir urea, white vinegar, borneol, parachloro-meta-xylenol, skin penetrant, alum and the multiple concentrated solutions obtained in step (2) to obtain a liquid for treating tinea pedis and tinea manuum. Stirring is carried out under normal pressure; the temperature during stirring is 40° C., and the stirring time is 1 hour.

[0043] In some other embodiments, the stirring temperature should be less than or equal to 60° C., and the stirring time should be between 0.5 and 1 h.

[0044] Example 2 Practical application of tinea manuum and pedis treatment liquid

[0045] The inventor was infected with tinea pedis bacteria in 1973 and visited various major specialist hospitals in Beijing for many times. He was diagnosed as a lifelong carrier of the bacteria. Later, the inventor was determined to overcome difficulties and made a breakthrough in 2011. He successfully cured tinea pedis diagnosed as "lifelong carrier" with his own formula, and there has been no recurrence since then. The relevant formula has obtained an invention patent (Grant Announcement No.: CN 102224975 B). On the basis of this patent, the inventor further adjusted the composition and preparation method of the tinea pedis treatment liquid in combination with patient feedback, and conducted a drug efficacy test on the tinea pedis treatment liquid prepared in Example 1.

[0046] Case 1: Wang, male, 32 years old, complained of tinea pedis for more than 2 years, with symptoms of dry cracks and bleeding on both feet. Soak socks with the tinea pedis treatment solution provided in Example 1 and provide them to the patient for wearing. Wear once every 10 days, 50 to 60 minutes each time. After wearing, remove the old skin on the affected area and wash it. After immersion treatment 3 times, the patient recovered. Follow-up for one year showed no recurrence.

[0047] Case 2: Li, female, 45 years old, had recurrent tinea pedis for 5 years. The patient had rough and itchy skin on both hands and feet, accompanied by small blisters and peeling. In February 2023, the patient was treated with gloves and socks soaked in the tinea pedis treatment solution in Example 1 and provided to the patient for treatment. Treatment was performed once a week, each time for 60 minutes. After the treatment, the old skin on the affected area was removed and then washed, and the treatment was continued for four weeks. During the treatment, the patient was careful to keep his hands and feet dry to avoid cross infection. After the treatment, the skin of the patient's hands and feet was significantly smoother, and the symptoms of itching and peeling disappeared. After six months of follow-up, the condition was stable and no recurrence was observed.

[0048] Case 3: Hu, male, 28 years old, acute tinea pedis infection for 1 week, self-reported poor accommodation conditions for business trips, sudden acute tinea pedis, redness, swelling, pain, accompanied by a large amount of exudate. The tinea manuum and pedis treatment liquid in Example 1 was used for emergency treatment, soaking the feet once a day, 60 minutes each time, for 3 consecutive days, and combined with external anti-inflammatory ointment. After three days, the redness and swelling subsided, the exudation decreased, and the symptoms disappeared completely after one week. The patient continued consolidation treatment for two weeks and followed up for three months, and no infection symptoms recurred.

[0049] Case 4: Yang, female, 58 years old, had intractable tinea manuum for 10 years, with thickened and severely keratinized skin on both hands, often with cracks between fingers, and unbearable pain. Since April 2022, the tinea manuum and pedis treatment liquid in Example 1 has been used for treatment. Soak the hands twice a week for 1 hour each time, remove the old skin after soaking, wear silicone gloves daily to keep the hands moist. After three months of continuous treatment, the skin of the hands gradually softened, the keratinized layer fell off, and the cracks healed. After two months of continued consolidation treatment, the skin of the hands returned to normal, and there was no recurrence after one year of follow-up.

[0050] Case 5: Liu, male, 15 years old, adolescent tinea pedis with interdigital erosion. Self-reported long-term football training, accidentally infected with tinea pedis, redness and swelling between the toes, exudate, accompanied by bad odor. After consultation, the tinea manuum and pedis treatment liquid in Example 1 was used for targeted treatment. Soak your feet before going to bed every day for 20 minutes each time, and pay special attention to cleaning and drying between the toes. After one week of treatment, the red and swollen surface was significantly reduced, the exudate decreased, and the symptoms basically disappeared after two weeks. To prevent recurrence, it is recommended that the patient continue to soak once a week for one month and strengthen personal hygiene habits. Follow-up so far, the patient's feet are healthy and no similar symptoms have recurred.

[0051] Statistics on the therapeutic effects of more than 200 patients showed that the total effective rate of the tinea pedis and tinea manuum prepared by the above method was 100%, and the cure rate was 78.6%.

[0052] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the claims of this patent application.

Claims

1. A medicinal solution for treating tinea pedis and tinea manuum, characterized in that: The raw materials used to make the tinea pedis treatment liquid include the following substances by weight: 6-8 parts of urea, 30-40 parts of white vinegar with acidity>9°, 6-8 parts of borneol, 5-9 parts of parachlorometaxylenol, 5-9 parts of alum, 12-16 parts of white ringworm peels, 8-10 parts of Kochia scoparia, 6-8 parts of cloves, 10-12 parts of Cnidium monnieri, 3-6 parts of Sophora flavescens, 2-4 parts of Zanthoxylum bungeanum, 1-3 parts of Rheum officinale, 2-4 parts of Angelica dahurica, 4-7 parts of Phellodendron amurense, 7-9 parts of Radix Sophorae Flavescentis, and 6-9 parts of skin penetrant.

2. A method for preparing a medicinal solution for treating tinea pedis and tinea manuum, characterized in that: The following steps are involved: (1) using an extractant to extract each medicinal material separately, and obtaining a plurality of extracts after filtering; (2) concentrating the multiple extracts obtained in step (1) respectively to obtain multiple concentrated solutions; (3) mixing urea, white vinegar with an acidity of more than 9°, borneol, parachlorometaxylenol, a skin penetrant, alum and the concentrated solution obtained in step (2) and stirring them uniformly to obtain a liquid medicine for treating tinea pedis and tinea manuum; The medicinal materials in step (1) are respectively as follows by weight: 12-16 parts of white ringworm peels, 8-10 parts of Kochia scoparia, 6-8 parts of cloves, 10-12 parts of Cnidium monnieri, 3-6 parts of Sophora flavescens, 2-4 parts of Zanthoxylum bungeanum, 1-3 parts of Rheum officinale, 2-4 parts of Angelica dahurica, 4-7 parts of Phellodendron amurense, and 7-9 parts of Radix Sophorae flavescentis; In step (3), the amounts of urea, white vinegar with an acidity of >9°, borneol, parachlorometaxylenol, skin penetrant and alum used are respectively: 6 to 8 parts of urea, 30 to 40 parts of white vinegar with an acidity of >9°, 6 to 8 parts of borneol, 5 to 9 parts of parachlorometaxylenol, 6 to 9 parts of skin penetrant and 5 to 9 parts of alum, by weight.

3. The method for preparing the tinea manuum and pedis treatment liquid according to claim 2, characterized in that: In step (1), the extractant used is water, and the extraction method is a cooking method.

4. The method for preparing the tinea pedis treatment liquid according to claim 2, characterized in that: In step (1), when the medicinal materials are extracted, the pressure in the extraction device is 0.1 MPa; when each medicinal material is extracted separately, the volume / weight ratio of the extractant to the medicinal material is 10:1 mL / g.

5. The method for preparing the tinea pedis treatment liquid according to claim 4, characterized in that: In step (1), the extraction temperature of white ringworm peel is 60-80°C, the extraction temperature of Kochia scoparia is 70-80°C, the extraction temperature of clove is 70-80°C, the extraction temperature of Cnidium monnieri is 60-80°C, the extraction temperature of Sophora flavescens is 70-80°C, the extraction temperature of Zanthoxylum bungeanum is 70-80°C, the extraction temperature of Rheum officinale is 70-80°C, the extraction temperature of Angelica dahurica is 70-80°C, the extraction temperature of Phellodendron chinense is room temperature, and the extraction temperature of Rhizoma Cyperi is 70-80°C.

6. The method for preparing the tinea pedis treatment liquid according to claim 2, characterized in that: In step (2), a vacuum rotary evaporator is used for concentration, the vacuum degree during concentration is 0.05-0.08Mpa, and the rotation speed is 100-200rpm; for any kind of medicinal material extract, the volume of the concentrated solution formed after concentration is 1 / 5 of the volume of the extract.

7. The method for preparing the tinea pedis treatment liquid according to claim 6, characterized in that: In step (2), the rotary evaporation temperature of the white ringworm peel extract is 50-55°C, the rotary evaporation temperature of the Kochia scoparia extract is 45-50°C, the rotary evaporation temperature of the clove extract is 45-50°C, the rotary evaporation temperature of the Cnidium monnieri extract is 55-60°C, the rotary evaporation temperature of the Sophora flavescens extract is 50-55°C, the rotary evaporation temperature of the Zanthoxylum bungeanum extract is 45-50°C, the rotary evaporation temperature of the Rheum officinale extract is 55-60°C, the rotary evaporation temperature of the Angelica dahurica extract is 50-55°C, the rotary evaporation temperature of the Phellodendron chinense extract is 25-35°C, and the rotary evaporation temperature of the Tussop cortex sylvestris extract is 50-55°C.

8. The method for preparing the tinea pedis treatment liquid according to claim 2, characterized in that: In step (3), the amounts of urea, white vinegar, borneol, parachlorometaxylenol, skin penetrant and alum used are respectively: 8 parts of urea, 40 parts of white vinegar, 8 parts of borneol, 9 parts of parachlorometaxylenol, 9 parts of skin penetrant and 9 parts of alum, by weight.

9. The method for preparing the tinea pedis treatment liquid according to claim 2, characterized in that: In step (3), the skin penetrant used is azone or dimethyl sulfoxide.

10. The method for preparing the tinea pedis treatment liquid according to claim 2, characterized in that: In step (3), stirring is carried out under normal pressure; the temperature during stirring is less than or equal to 60° C., and the stirring time is 0.5 to 1.0 h.

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