Xianglian stagnation transforming composition for treating infantile hot dysentery

Abstract

The invention relates to a radix aucklandiae and rhizoma coptidis stagnation transforming composition for treating infantile heat dysentery. The composition is prepared from 10-20 g of radix aucklandiae, 5-15 g of fructus aurantii immaturus, 5-20 g of radix glycyrrhizae, 10-30 g of rhizoma coptidis, 10-30 g of radix scutellariae, 5-15 g of betel nut slices, 5-15 g of cortex magnoliae officinalis, 5-15 g of pericarpium citri reticulatae viride, 10-30 g of radix angelicae sinensis, 5-15 g of fructus forsythiae, 5-15 g of pericarpium citri reticulatae, 10-30 g of radix paeoniae rubra, 5-15 g of talcum powder and 20-50 g of radix et rhizoma rhei. The composition is obtained by improving an existing Xianglian stagnation eliminating pill prescription, radix paeoniae alba in the Xianglian stagnation eliminating pill is changed into wine-processed radix paeoniae rubra, the effects of clearing heat and cooling blood are enhanced, and the cold property of the radix paeoniae alba medicine is relieved; in addition, the rhubarb and the fructus forsythiae are added, and the rhubarb, the talcum powder, the radix scutellariae and the rhizoma coptidis jointly achieve the effects of eliminating dampness and heat in intestinal tracts, stopping dysentery, cooling blood, eliminating evil and calming the body resistance; the lotus meat is matched with the pericarpium citri reticulatae, the pericarpium citri reticulatae viride, the fructus aurantii immaturus and the radix aucklandiae, so that the effects of tonifying spleen, promoting the circulation of qi, removing food retention, relieving dyspepsia and strengthening diarrhea with astringents can be achieved, and the prescription has a relatively good treatment effect on damp-heat dysentery and epidemic diarrhea.

Description

Technical Field

[0001] The invention relates to the field of medicine, and more particularly to a Xianglian Huazhi composition for treating febrile dysentery in children. Background Art

[0002] Heat dysentery is a common disease in summer and autumn. The pathogenesis of heat dysentery is divided into damp-heat dysentery and epidemic dysentery. Damp-heat dysentery is affected by damp-heat evil. At the same time, damp-heat is contained in the body, and food cannot be digested, stagnating in the middle and lower parts of the body. The exogenous evil and the internal damp-heat stagnate in the stomach and intestines, causing the water and grain to not be properly decomposed. The evil qi and the corrupted things are combined, and the qi and blood of the stomach and intestines are stagnant in the intestines. The key to the pathogenesis of damp-heat heat dysentery is that damp-heat and corrupted food are combined in the stomach and intestines, and the evil qi and corrupted water and grain are soaked in the middle and lower parts of the body. When damp-heat dysentery occurs, the dysentery is red and white, sticky like jelly, fishy, ​​burning in the anus, short and red urine, intermittent abdominal pain, pain and refusal to press, abdominal pain temporarily relieved after defecation, yellow and greasy tongue coating, slippery and rapid pulse. Treatment should be clearing the intestines to eliminate dampness, detoxification, regulating qi and promoting blood circulation. The key point of the pathogenesis of epidemic dysentery is the object of epidemic toxicity. The evil is strong inside, and the evil of epidemic toxicity fills the stomach and intestines, and the food cannot be digested. It also combines with the blood of the stomach and intestines, and the poison, bad food, and rotten blood are mixed down. The onset of epidemic toxic dysentery is rapid, with vomiting, tenesmus, frequent bowel movements, and even incontinence. The pus and blood in the dysentery are bright purple, the limbs are cold, the mouth is dry, irritability, and confusion. In severe cases, the mind is confused, vomiting frequently, and convulsions occur from time to time. In severe cases, the pupils are unequal in size, the tongue is red and the coating is yellow and dry, and the pulse is slippery and rapid or weak and about to stop; the treatment should be to clear away heat, detoxify, and cool the blood. For the above-mentioned hot dysentery, the prescriptions of Bai Tou Weng Decoction, Qinlian Shaoyao Decoction, and Xianglian Pills are commonly used.

[0003] Xianglian Huazhi Pills are composed of 60 grams each of costus root and coptis root, 75 grams each of fried green peel, dried tangerine peel, Magnolia officinalis (roasted), fried immature bitter orange, and scutellaria baicalensis; 150 grams each of angelica and white peony root, and 60 grams each of talc, licorice, and areca catechu; it has the effects of clearing away heat and dampness, eliminating accumulation and relieving stagnation, can treat dysentery caused by damp-heat in the large intestine, and is mainly used to treat red and white diarrhea during pregnancy; it is not effective in treating dysentery caused by epidemic toxins. Summary of the invention

[0004] The invention aims to provide a Xianglian Huazhi composition for treating heat dysentery in children. The composition is obtained by improving the existing Xianglian Huazhi pill prescription. The white peony root in the Xianglian Huazhi pill is replaced with red peony root processed with wine, which not only enhances the effect of clearing heat and cooling blood, but also alleviates the coldness of the white peony root. In addition, rhubarb and lotus seed pulp are added. The rhubarb, talcum powder, scutellaria baicalensis and coptis chinensis can work together to eliminate intestinal damp-heat, stop dysentery and cool blood, and remove evil and calm the body. Lotus seed is compatible with tangerine peel, green peel, immature bitter orange and costus root, which can invigorate the spleen and promote qi, eliminate accumulation and remove stagnation, and enhance the effect of astringing the intestine and stopping diarrhea. The prescription has a uniform and good therapeutic effect on damp-heat dysentery and epidemic dysentery.

[0005] To achieve the above object, the present invention adopts the following technical solution:

[0006] A fragrant and lianhuazhi composition for treating febrile dysentery in children, the composition comprising 10-20g of costusroot, 5-15g of immature bitter orange, 5-20g of liquorice, 10-30g of coptis root, 10-30g of scutellaria baicalensis, 5-15g of betel nut slices, 5-15g of magnolia bark, 5-15g of green tangerine peel, 10-30g of angelica, 5-15g of lian flesh, 5-15g of tangerine peel, 10-30g of red peony root, 5-15g of talcum powder, and 20-50g of rhubarb.

[0007] As a preferred embodiment of the present invention, the composition is composed of 10g of costus root, 10g of immature bitter orange, 10g of liquorice, 20g of coptis root, 20g of scutellaria baicalensis, 10g of betel nut slices, 10g of magnolia bark, 10g of green tangerine peel, 20g of angelica sinensis, 10g of tangerine peel, 10g of red peony root, 10g of talcum powder, and 40g of rhubarb.

[0008] As the preferred embodiment of the present invention, the Citrus aurantium is stir-fried Citrus aurantium with bran (the Citrus aurantium is processed with wheat bran and used), the Magnolia officinalis is ginger Magnolia officinalis (raw Magnolia officinalis is processed with ginger juice and used); the Citrus aurantium is vinegar Citrus aurantium (the Citrus aurantium is stewed and fried with vinegar and then dried for use as medicine); the Red Peony Root is wine-processed Red Peony Root (the Red Peony Root is stewed and fried with wine and then dried for use as medicine); the Betel Nut Slices are stir-fried Betel Nut Slices (a medicinal material made by stir-frying raw Betel Nut).

[0009] The drug components of the Xianglian Huazhi composition provided by the present invention are strictly compatible with each other, each drug component performs its own function, and cooperates with each other to jointly exert the effects of clearing away heat and dampness, promoting blood circulation and removing stagnation, cooling blood and detoxifying; it has a good therapeutic effect on damp-heat dysentery and epidemic toxic dysentery in children, so the Xianglian Huazhi composition can be used in the preparation of drugs for treating pediatric heat dysentery; the heat dysentery includes damp-heat dysentery and epidemic toxic dysentery.

[0010] The Xianglian Huazhi composition for treating pediatric febrile dysentery of the present invention is an oral preparation; wherein the oral preparation is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

[0011] The present invention also provides a Xianglian Huazhi powder for treating pediatric heat dysentery, which is composed of the following raw materials by weight: 10-20g of costusroot, 5-15g of bran-fried immature bitter orange, 5-20g of liquorice, 10-30g of coptis root, 10-30g of scutellaria baicalensis, 5-15g of betel nut slices, 5-15g of ginger magnolia bark, 5-15g of vinegar green peel, 10-30g of angelica, 5-15g of lian flesh, 5-15g of tangerine peel, 10-30g of wine-processed red peony root, 5-15g of talcum powder, and 20-50g of rhubarb;

[0012] The preparation method of the Xianglian Huazhi powder is as follows: mix the above 14 ingredients, crush them into fine powder, sieve, mix them evenly, and package them.

[0013] Advantages and beneficial effects of the present invention:

[0014] (1) The Xianglian Huazhi composition provided by the present invention is obtained by improving the existing Xianglian Huazhi Pills prescription, and the white peony root in the Xianglian Huazhi Pills is replaced with red peony root processed with wine, which not only enhances the effect of clearing heat and cooling blood, but also alleviates the coldness of the white peony root, and also has the effects of relieving pain, enhancing immune function, and resisting pathogenic microorganisms; in addition, rhubarb and lian meat are added to the prescription, and rhubarb clears heat and purges fire, cools blood and detoxifies, and together with talcum powder, scutellaria and coptis root, it can eliminate intestinal dampness and heat, stop dysentery, cool blood, and remove evil and calm the body. Rhubarb, talcum powder, scutellaria baicalensis and coptis chinensis can work together to remove intestinal dampness and heat, stop dysentery and cool blood, and remove evil and restore health; lotus seeds are sweet and astringent, and can strengthen the spleen and stop diarrhea. Lotus seeds are used with tangerine peel, vinegar-fried green peel, bran-fried immature bitter orange, and costus root to strengthen the spleen and promote qi circulation, eliminate accumulation and remove stagnation, and enhance the effect of astringing the intestines and stopping diarrhea. The medicinal ingredients in this prescription are strictly compatible, and each medicinal ingredient performs its own function, and cooperates with each other to jointly play the effects of clearing away heat and dampness, promoting blood circulation and removing stagnation, cooling blood and detoxifying, and have a good therapeutic effect on damp-heat dysentery and epidemic dysentery.

[0015] (2) In the Xianglian Huazhi composition provided by the present invention, both Coptis chinensis and Scutellaria baicalensis are key herbs for clearing away heat and drying dampness. The combination of the two can significantly enhance the effect of clearing away heat and removing dampness; Aucklandia lappa is pungent and bitter, and is good at removing qi stagnation in the spleen, stomach and large intestine, and is a key herb for promoting qi and relieving pain; when combined with Coptis chinensis and Scutellaria baicalensis, it can not only clear away heat and dry dampness, but also promote qi and relieve pain, and has a good therapeutic effect on symptoms such as abdominal pain and tenesmus caused by damp-heat blocking the qi mechanism; Fried Citrus aurantium immaturus with bran can break up qi and eliminate stagnation, eliminate accumulation and guide stagnation; Ginger Magnolia officinalis can dry dampness and eliminate phlegm, and relieve qi and eliminate fullness. The combination of the two can enhance the effect of promoting qi and eliminating stagnation, and has a significant therapeutic effect on symptoms such as indigestion and abdominal distension; Tangerine peel can regulate qi and strengthen the spleen, dry dampness and eliminate stagnation phlegm; vinegar and green peel soothe the liver and break up qi, disperse stagnation and eliminate stagnation. The combination of the two can not only regulate qi and harmonize the stomach, but also soothe the liver and relieve depression. It has a good effect on symptoms such as chest and abdominal distension and pain caused by liver-stomach disharmony and qi stagnation; betel nut is pungent, dispersing and bitter, and enters the gastrointestinal meridian, is good at promoting gastrointestinal qi, eliminating accumulation and guiding stagnation, and can also relieve constipation. After frying, its medicinal properties are more mild, and when used with the above-mentioned drugs, they can jointly play the role of promoting qi and eliminating stagnation, guiding stagnation and relieving constipation; talcum powder is sweet, cold and slippery, and can clear away heat and dampness, open the orifices and relieve stranguria; angelica sinensis replenishes blood and promotes blood circulation, moisturizes the intestines and promotes constipation; licorice harmonizes all the drugs and relieves pain. These four drugs work together to clear away heat and dampness, promote blood circulation and relieve pain, and moisturize the intestines and promote constipation.

[0016] (3) The Xianglian Huazhi composition provided by the present invention has a rapid effect, does not hurt the spleen and stomach, has a total effective rate of 100% for damp-heat dysentery, and a total effective rate of 94.4% for epidemic dysentery, and has a significant therapeutic effect. DETAILED DESCRIPTION

[0017] The present invention discloses a Xianglian Huazhi composition for treating pediatric febrile dysentery. Those skilled in the art can refer to the contents of this article and appropriately improve the component parameters or process parameters to achieve the effect. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art and are deemed to be included in the protection scope of the present invention.

[0018] Example 1

[0019] This embodiment provides a Xianglian Huazhi composition for treating heat dysentery in children, the composition is composed of 10g of costus root, 10g of immature bitter orange, 10g of liquorice, 20g of coptis root, 20g of scutellaria baicalensis, 10g of betel nut slices, 10g of magnolia bark, 10g of green peel, 20g of angelica, 10g of lian flesh, 10g of tangerine peel, 20g of red peony root, 10g of talcum powder, and 40g of rhubarb;

[0020] Among them, the Citrus aurantium is stir-fried with bran, the Magnolia officinalis is Magnolia officinalis with ginger; the Citrus aurantium peel is vinegar-prepared Citrus aurantium peel; the Red Peony Root is wine-prepared Red Peony Root; and the Betel Nut Slices are stir-fried Betel Nut Slices.

[0021] The Xianglian Huazhi composition provided in this embodiment can be made into an oral preparation in actual use; the oral preparation includes powders, granules, tablets, capsules, oral liquids or pills, etc. Among the above dosage forms, powders have the advantage of being simple and easy to prepare, so powders are preferred.

[0022] Specifically, the preparation method of the powder (Xianglian Huazhi Powder) is: mix the above 14 ingredients, crush them into fine powder, sieve, mix them evenly, and package them.

[0023] It should be noted that the bran-fried Citrus aurantium in the Xianglian Huazhi Powder provided in this embodiment refers to the Citrus aurantium prepared with wheat bran, the ginger Magnolia bark refers to the raw Magnolia bark prepared with ginger juice, the vinegar-processed green peel refers to the green peel stewed and fried with vinegar and then dried for medicine, the wine-processed red peony root refers to the red peony root stewed and fried with wine and then dried for medicine, and the fried betel nut slices are the medicinal materials fried with raw betel nut. The processing methods of the above-mentioned medicinal materials are all processed using existing processes. The specific preparation method is not the key point of this application. Those skilled in the art can directly use the existing commercially available processed products as medicine.

[0024] Example 2

[0025] This embodiment provides a Xianglian Huazhi composition for treating pediatric heat dysentery, the composition comprising 15g of costusroot, 10g of immature bitter orange, 15g of liquorice, 15g of coptis root, 20g of scutellaria, 15g of areca slices, 15g of magnolia bark, 5g of green peel, 25g of angelica, 10g of lian flesh, 10g of tangerine peel, 20g of red peony root, 10g of talcum powder, and 30g of rhubarb;

[0026] Among them, the Citrus aurantium is stir-fried with bran, the Magnolia officinalis is Magnolia officinalis with ginger; the Citrus aurantium peel is vinegar-prepared Citrus aurantium peel; the Red Peony Root is wine-prepared Red Peony Root; and the Betel Nut Slices are stir-fried Betel Nut Slices.

[0027] In the Xianglian Huazhi composition provided by the present invention, the white peony root in the Xianglian Huazhi pill is replaced with red peony root processed with wine, which not only enhances the effect of clearing heat and cooling blood, but also alleviates the coldness of the white peony root, and also has the effects of relieving pain, enhancing immune function, and resisting pathogenic microorganisms; in addition, rhubarb and lianrou are added to the formula, and rhubarb clears heat and purges fire, cools blood and detoxifies, and together with talcum powder, scutellaria baicalensis and coptis chinensis, it has the effects of removing intestinal dampness and heat, stopping dysentery and cooling blood, and removing evil and calming the body; rhubarb, talcum powder, scutellaria baicalensis and coptis chinensis The lotus seeds are sweet and astringent, and can invigorate the spleen and stop diarrhea. Lotus seeds are compatible with dried orange peel, vinegar green peel, bran fried bitter orange, and costus root, which can invigorate the spleen and promote qi, eliminate accumulation and guide stagnation, and strengthen the effect of astringing the intestines and stopping diarrhea. The compatibility between the drug components of this prescription is rigorous, and each drug component performs its own duties and cooperates with each other to jointly play the effects of clearing heat and dampness, promoting blood circulation and removing stagnation, cooling blood and detoxifying, and has a uniform and good therapeutic effect on damp-heat dysentery and epidemic dysentery. This prescription has been used in Jilin Children's Hospital for many years. The following clinical data will illustrate the therapeutic effect of the fragrant and stagnant composition of the present invention, as follows:

[0028] 1. Clinical data

[0029] A total of 56 children with heat dysentery admitted to Jilin Children's Hospital from March 2021 to December 2021 were selected as research subjects. They were randomly divided into a study group and a control group, with 28 cases in each group; the study group had 15 males and 13 females, aged 3 to 12 years old, 10 children with damp-heat dysentery (typical clinical symptoms were red and white diarrhea, jelly-like, intermittent abdominal pain, and temporary abdominal pain after defecation), and 18 children with epidemic dysentery (typical clinical symptoms were vomiting, frequent defecation, pus and blood in diarrhea, and fever); the control group had 13 males and 15 females, aged 2 to 12 years old, 12 children with damp-heat dysentery, and 16 children with epidemic dysentery. There was no statistically significant difference in general data between the two groups, and they were comparable. Severe malnutrition and other systemic diseases were excluded.

[0030] 2. Treatment Methods

[0031] The two groups of children were given fluid replacement, correction of water and electrolyte disorders, correction of acidosis, nutritional support therapy and symptomatic treatment. The control group was given Xianglian Huazhi Pills (Beijing Tongrentang, each pill weighs 6g), 2 to 3 years old, 3g once, twice a day; 4 to 6 years old, 4g once, twice a day; 7 to 10 years old, 6g once, twice a day; over 10 years old, 8g once, twice a day; The research group was given Xianglian Huazhi Powder of Example 1, 2 to 3 years old: 1g once, twice a day; 4 to 6 years old, 2g once, twice a day; 7 to 10 years old, 3.5g once, twice a day; over 10 years old, 5g once, twice a day.

[0032] 3. Observation indicators

[0033] The evaluation criteria for the overall clinical efficacy are as follows:

[0034] Markedly effective: stool characteristics and frequency return to normal (<3 times / day) within 72 hours of treatment, and systemic symptoms disappear;

[0035] Effective: The stool characteristics and frequency are significantly improved within 72 hours of treatment, and systemic symptoms are significantly improved;

[0036] Ineffective: There is no improvement in stool characteristics and systemic symptoms within 72 hours of treatment, or even worsens, and other drug treatments must be switched.

[0037] Total effective rate = (markedly effective + effective) / total number of cases × 100%.

[0038] 4. Treatment Outcomes

[0039] The comparison of the overall clinical efficacy between the two groups of children is shown in Table 1.

[0040] Table 1 shows the comparison of the total effective rate of treatment between the two groups of children

[0041]

[0042] Compared with the control group: * P<0.05.

[0043] The above description is a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A Xianglian Huazhi composition for treating febrile dysentery in children, characterized in that: The composition consists of 10-20g of costusroot, 5-15g of immature bitter orange, 5-20g of liquorice, 10-30g of coptis root, 10-30g of scutellaria baicalensis, 5-15g of betel nut slices, 5-15g of magnolia bark, 5-15g of green tangerine peel, 10-30g of angelica sinensis, 5-15g of tangerine peel, 10-30g of red peony root, 5-15g of talcum powder and 20-50g of rhubarb.

2. The Xianglian Huazhi composition for treating febrile dysentery in children according to claim 1, characterized in that: The composition consists of 10g of costusroot, 10g of immature bitter orange, 10g of liquorice, 20g of coptis root, 20g of scutellaria baicalensis, 10g of betel nut slices, 10g of magnolia bark, 10g of green tangerine peel, 20g of angelica sinensis, 10g of tangerine peel, 10g of red peony root, 10g of talcum powder and 40g of rhubarb.

3. A Xianglian Huazhi composition for treating febrile dysentery in children according to claim 1 or 2, characterized in that: The Citrus aurantium is stir-fried with bran, the Magnolia officinalis is Magnolia officinalis with ginger; the Citrus aurantium peel is Citrus aurantium with vinegar; the Red Peony Root is Red Peony Root processed with wine; and the Areca Nut Slices are stir-fried Areca Nut Slices.

4. Use of the Xianglian Huazhi composition according to claim 3 in the preparation of a medicine for treating febrile dysentery in children.

5. The use according to claim 4, characterized in that: The heat dysentery includes damp-heat dysentery and epidemic toxic dysentery.

6. The use according to claim 4, characterized in that: The Xianglian Huazhi composition is an oral preparation; wherein, the oral preparation is selected from any one of powders, granules, tablets, capsules, oral liquids or pills.

7. A Xianglian Huazhi powder for treating febrile dysentery in children, characterized in that: The Xianglian Huazhi powder is composed of the following raw materials by weight: 10-20g of costusroot, 5-15g of bran-fried immature bitter orange, 5-20g of liquorice, 10-30g of coptis root, 10-30g of scutellaria root, 5-15g of betel nut slices, 5-15g of ginger and magnolia bark, 5-15g of vinegar green peel, 10-30g of angelica, 5-15g of lian flesh, 5-15g of tangerine peel, 10-30g of wine-processed red peony root, 5-15g of talcum powder, and 20-50g of rhubarb; The preparation method of the Xianglian Huazhi powder is as follows: mix the above 14 ingredients, crush them into fine powder, sieve, mix them evenly, and package them.

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