A nucleic acid POCT detector

Abstract

The application discloses a nucleic acid POCT detector. The detection device of the detector comprises a consumable bin, a mobile mechanical arm module, a nucleic acid extraction and purification module and an amplification and detection module. The mobile mechanical arm module is provided with a magnetic bar position for installing a magnetic bar, a suction nozzle position and a first clamping jaw. The amplification and detection module is used for amplifying and real-time fluorescent detecting the nucleic acid in the sample to be detected. The application provides a detector which can automatically complete nucleic acid detection. The detector has multiple detection channels and can simultaneously detect one or more samples. The detector adopts rapid temperature rising and falling, rapid and accurate constant temperature, photoelectric signal denoising and amplification and other technical means, achieves high integration, high automation and extreme miniaturization, can automatically complete 1 to 21 pathogen nucleic acid detection from the sample to the result within 30 minutes, and can send the result. Compared with the traditional fluorescent PCR method, the detection time is greatly shortened, the convenience is greatly improved, the requirements for professionals and places are very low, and therefore the application range is wide.

Description

Technical Field

[0001] This invention relates to the field of nucleic acid testing instrument technology, and in particular to a nucleic acid POCT testing instrument. Background Technology

[0002] In existing technologies, the testing personnel typically use a pipette to draw up the sample, then add it to a reaction tube, and use a PCR amplification instrument to perform nucleic acid testing.

[0003] However, this testing method relies heavily on manual operation, which is inefficient and may lead to inaccurate results due to improper operation. Summary of the Invention

[0004] The main objective of this invention is to provide a nucleic acid POCT detection instrument, which aims to automate nucleic acid detection, improve detection efficiency, and enhance the accuracy of detection results.

[0005] To achieve the above objectives, the present invention proposes a nucleic acid POCT detection instrument, comprising at least one detection device, wherein each detection device includes:

[0006] Support platform;

[0007] The consumables compartment is located on the support platform and is provided with a reagent tank holding position for placing reagent tanks, a sample tube holding position for placing sample tubes, and a reaction tube holding position for placing reaction tubes.

[0008] A mobile robotic arm module, mounted on the support platform, is equipped with a magnetic rod mounting position, a suction nozzle mounting position, and a first gripper for holding the reaction tube and / or the sample tube and opening / closing it; and

[0009] An amplification and detection module is mounted on the support platform and has a detection slot for accommodating the reaction tube. The amplification and detection module is used to amplify nucleic acids in the sample to be tested and perform real-time fluorescence detection.

[0010] Optionally, the nucleic acid POCT detector further includes a first driving mechanism, which is drivenly connected to the consumables compartment and used to drive the consumables compartment to slide in and out relative to the support platform.

[0011] Optionally, the mobile robotic arm module includes a slide rail, a slider, a second drive mechanism, a third drive mechanism, and a fourth drive mechanism. The slider is slidably disposed on the slide rail and drivenly connected to the second drive mechanism. The second drive mechanism is used to drive the slider to slide. The first gripper is disposed on the slider and drivenly connected to the third drive mechanism and the fourth drive mechanism respectively. The third drive mechanism is used to drive the first gripper to open and close, and the fourth drive mechanism is used to drive the first gripper to rotate to open / close the cover.

[0012] Optionally, the sample tube accommodating position is formed by a second gripper disposed on the support platform. The second gripper is connected to a fifth driving mechanism, which is used to drive the second gripper to open and close.

[0013] Optionally, a movable light-blocking component is provided at the opening of the detection slot, and the first gripper is also used to grip or push the movable light-blocking component and move the movable light-blocking component under the drive of the second driving mechanism.

[0014] Optionally, the mobile robotic arm module further includes a magnetic rod mounting block and a sixth drive mechanism. The magnetic rod is mounted on the magnetic rod mounting block, and the magnetic rod mounting block is vertically and vertically mounted on the slider and drivenly connected to the sixth drive mechanism. The sixth drive mechanism is used to drive the magnetic rod mounting block to perform vertical movement.

[0015] Optionally, the mobile robotic arm module further includes a suction nozzle mounting block and a seventh drive mechanism. The suction nozzle is located on the suction nozzle mounting block, and the suction nozzle mounting block is vertically and vertically mounted on the slider and drivenly connected to the seventh drive mechanism. The seventh drive mechanism is used to drive the suction nozzle mounting block to perform vertical movement.

[0016] Optionally, the consumables compartment further includes a consumables rack, which is mounted on the support platform and has a plurality of magnetic rod slots for placing the magnetic rods and a plurality of nozzle slots for placing the nozzles.

[0017] Optionally, the nucleic acid POCT detector further includes a heating device, which is located at the bottom of the reagent tank and used to heat and amplify the sample to be tested.

[0018] Optionally, the nucleic acid POCT detector further includes a barcode scanner, which is disposed on the support platform and close to the sample tube receiving position, and is used to identify the sample information of the sample tube.

[0019] In the technical solution of this invention, the nucleic acid POCT detector includes a support platform and at least one detection device disposed on the support platform. Each detection device includes a consumable compartment, a mobile robotic arm module, and an amplification detection module. The consumable compartment is disposed on the support platform and has a reagent compartment for placing reagent slots, a sample tube compartment for placing sample tubes, and a reaction tube compartment for placing reaction tubes. The mobile robotic arm module is mounted on the support platform and has a magnetic rod compartment for mounting magnetic rods, a pipette compartment for mounting pipette tips, and a first gripper for clamping reaction tubes and / or sample tubes and opening / closing them. The amplification detection module is disposed on the support platform and has a detection slot for accommodating reaction tubes. The amplification detection module is used for amplifying nucleic acids in the sample to be tested and performing real-time fluorescence detection. It can be understood that by setting at least one detection device, this invention can simultaneously perform nucleic acid detection on at least one sample. Operations such as opening / closing, sampling, extraction, and detection are all automatically completed by the machine, significantly improving nucleic acid detection efficiency, achieving automation of nucleic acid detection, and effectively avoiding inaccurate detection results due to improper operation, thus improving the accuracy of the detection results. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the structure of an embodiment of the four-channel nucleic acid POCT detection instrument of the present invention;

[0022] Figure 2 This is a schematic diagram of the structure of an embodiment of the dual-channel nucleic acid POCT detection instrument of the present invention;

[0023] Figure 3 This is a schematic diagram of the reaction tube structure in one embodiment of the dual-channel nucleic acid POCT detector of the present invention.

[0024] Explanation of icon numbers:

[0025] 100. Support platform; 200. Detection device; 10. Consumables compartment; 20. Mobile robotic arm module; 30. Amplification detection module; 101. Reagent tank holding position; 102. Sample tube holding position; 103. Reaction tube holding position; 201. Magnetic rod position; 202. Pipette position; 203. First gripper; 301. Detection tank; 221. Slide rail; 222. Slider; 223. Second drive mechanism; 224. Third drive mechanism 225. Fourth drive mechanism; 104. Consumable rack; 105. Fifth drive mechanism; 302. Movable light-blocking component; 228. First drive mechanism; 226. Sixth drive mechanism; 227. Seventh drive mechanism; 110. Container body; 120. Light-transmitting component; 130. Cover; 10a. Notch; 10b. Flow channel; 111. Detection hole; 11. Circular tube; 12. Diverter plate; 112. Protruding column.

[0026] The realization of the objective, functional features and advantages of the present invention will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation

[0027] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0028] It should be noted that all directional indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present invention are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indication will also change accordingly.

[0029] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0030] Furthermore, the use of terms such as "first" and "second" in this invention is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the word "and / or" throughout the text means including three parallel solutions; for example, "A and / or B" includes solution A, solution B, or a solution that simultaneously satisfies A and B. Furthermore, the technical solutions of the various embodiments can be combined with each other, but this must be based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or impossible to implement, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection claimed by this invention.

[0031] This invention proposes a nucleic acid POCT detection instrument for detecting pathogen nucleic acids, but this is not limited to this.

[0032] Reference Figure 1 and Figure 2 In some embodiments of the present invention, the nucleic acid POCT detector includes a support platform 100 and at least one detection device 200 disposed on the support platform 100. Each detection device 200 includes a consumable compartment 10, a mobile robotic arm module 20, and an amplification detection module 30. The consumable compartment 10 is disposed on the support platform 100 and has a reagent compartment holding position 101 for placing reagent compartments, a sample tube holding position 102 for placing sample tubes, and a reaction tube holding position 103 for placing reaction tubes. The mobile robotic arm module 20 is mounted on the support platform 100 and has a magnetic rod position 201 for mounting magnetic rods, a pipette position 202 for mounting pipette tips, and a first gripper 203 for clamping reaction tubes and / or sample tubes and opening / closing them. The amplification detection module 30 is disposed on the support platform 100 and has a detection slot 301 for holding reaction tubes. The amplification detection module 30 is used to amplify nucleic acids in the sample to be tested and perform real-time fluorescence detection. The magnetic rod, pipette tips, and reagent compartment constitute a nucleic acid extraction and purification module.

[0033] In this embodiment, the aforementioned accommodating position can be a slot structure, a clamping structure, a supporting structure, etc., and is not limited here.

[0034] In this embodiment, the magnetic rod and the suction nozzle can be installed using detachable methods such as snap-fit ​​or plug-in, and there is no limitation here.

[0035] In this embodiment, the nucleic acid POCT detector is also equipped with a heating device, which is located at the bottom of the reagent tank and is used to heat and amplify the sample to be tested.

[0036] During nucleic acid testing, the mobile robotic arm module 20, equipped with a pipette, moves to the sample tube receiving position 102 to pick up the sample, then moves it to the reagent tank receiving position 101 and adds it to the reagent tank. The mobile robotic arm module 20, equipped with a magnetic rod, then inserts it into the reagent tank for adsorption. After the nucleic acid is heated and amplified, the mobile robotic arm module 20, equipped with a first gripper 203, opens / closes the lid of the reaction tube. Then, the pipette is used to pick up the test solution into the reaction tube, and finally, the test sample is subjected to fluorescence detection.

[0037] It is understood that by setting up at least one detection device 200, the present invention can simultaneously perform nucleic acid detection on at least one sample, and the operations such as opening / closing the cap, sampling, extraction, and detection are all automatically completed by the machine, which greatly improves the efficiency of nucleic acid detection, realizes the automation of nucleic acid detection, and effectively avoids inaccurate test results due to improper operation, thereby improving the accuracy of test results.

[0038] To facilitate the retrieval and placement of consumables and further improve operational convenience, refer to Figure 1 and Figure 2 In some embodiments, the nucleic acid POCT detector further includes a first driving mechanism 228, which is drivenly connected to the consumables compartment 10 and used to drive the consumables compartment 10 to slide in and out relative to the support platform 100.

[0039] In this embodiment, the first drive mechanism 228 and the following second drive mechanism 223, third drive mechanism 224, fourth drive mechanism 225, fifth drive mechanism 105, sixth drive mechanism 226 and seventh drive mechanism 227 can be motors, cylinders, hydraulic cylinders, etc., and are not limited here.

[0040] Reference Figure 1 and Figure 2In some embodiments, the mobile robotic arm module 20 may include a slide rail 221, a slider 222, a second drive mechanism 223, a third drive mechanism 224, and a fourth drive mechanism 225. The slider 222 is slidably mounted on the slide rail 221 and drivenly connected to the second drive mechanism 223, which drives the slider 222 to slide. A first gripper 203 is mounted on the slider 222 and drivenly connected to the third drive mechanism 224 and the fourth drive mechanism 225, respectively. The third drive mechanism 224 drives the first gripper 203 to open and close, and the fourth drive mechanism 225 drives the first gripper 203 to rotate to open / close the lid of the reaction tube, wherein the bottom of the reaction tube can be limited by its corresponding slot. Furthermore, the first gripper 203 may also be equipped with an independent lifting motor for convenient gripping of items. Thus, the first gripper 203 can slide along the length of the slide rail 221 and perform lifting movements, while also functioning as an open / close lid, further improving the automation level of the nucleic acid POCT detector and significantly increasing detection efficiency.

[0041] Specifically, the first gripper 203 in this embodiment may include a mounting base, a rod, and two clamping blocks. One end of the rod is connected to the third drive mechanism 224, and the other end of the rod is movably inserted into the mounting base and has two inclined surfaces. The two clamping blocks are disposed opposite each other on the mounting base and abut against the inclined surfaces on the rod. The mounting base is connected to the fourth drive mechanism 225 via a belt drive mechanism. This allows the first gripper 203 to open and close to accommodate the clamping needs of liquid tubes or bottles of different sizes and to meet the requirements of automatic opening / closing, thus broadening its applicability.

[0042] In addition, to mitigate damage caused by collisions between the moving parts of the drive mechanism and other components, and to extend its service life, refer to Figure 1 and Figure 2 In some embodiments, each drive component that performs lifting motion can be provided with a lifting block at its output end, and a buffer such as a spring is provided between the lifting block and the fixed seat of the corresponding drive component.

[0043] To facilitate the handling of sample tubes and to automatically open / close the caps, thereby further improving automation, based on the above embodiment, the sample tube receiving position 102 is composed of a second gripper mounted on the support stage 100. The second gripper is connected to a fifth drive mechanism 105, which drives the second gripper to open and close. In this embodiment, the first gripper 203 and the second gripper can be used in conjunction. The second gripper clamps the bottom of the sample tube, and the first gripper 203 clamps the cap, then rotates to open / close the cap of the sample tube.

[0044] To avoid light interference with fluorescence detection and further improve the accuracy of the detection results, refer to... Figure 1 and Figure 2In some embodiments, a movable light-blocking member 302 is provided at the opening of the detection slot 301, and the first gripper 203 is also used to grip or push the movable light-blocking member 302 and move the movable light-blocking member 302 under the drive of the second drive mechanism 223.

[0045] To further improve the automation level of this nucleic acid POCT testing instrument, increase testing efficiency, and save labor costs, refer to Figure 1 and Figure 2 In some embodiments, the mobile robotic arm module 20 may further include a magnetic rod mounting block and a sixth drive mechanism 226. The magnetic rod position 201 is disposed on the magnetic rod mounting block, and the magnetic rod mounting block is vertically mounted on the slider 222 and drivenly connected to the sixth drive mechanism 226. The sixth drive mechanism 226 is used to drive the magnetic rod mounting block to perform vertical movement.

[0046] In this embodiment, the mobile robotic arm module 20 also includes a suction nozzle mounting block and a seventh drive mechanism 227. The suction nozzle position 202 is disposed on the suction nozzle mounting block. The suction nozzle mounting block is vertically mounted on the slider 222 and is drivenly connected to the seventh drive mechanism 227. The seventh drive mechanism 227 is used to drive the suction nozzle mounting block to perform vertical movement.

[0047] To facilitate the retrieval and placement of various testing consumables and further improve testing efficiency, in some embodiments, the consumables compartment 10 also includes a consumables rack 104. The consumables rack 104 is mounted on the support platform 100 and is provided with a number of magnetic rod slots for placing magnetic rods and a number of suction nozzle slots for placing suction nozzles.

[0048] To achieve automatic printing of test reports, refer to Figure 1 and Figure 2 In some embodiments, the nucleic acid POCT detector also includes a barcode scanner and a printer, which are respectively mounted on the support platform 100. The barcode scanner is positioned near the sample tube receiving position 102. The barcode scanner is used to identify the sample information of the sample tube, and the printer is used to print the test report.

[0049] Furthermore, the single-use pre-packaged nucleic acid extraction and membrane-walled PCR amplification reaction tube used with the nucleic acid POCT detection instrument of this invention is an original product, suitable for automated operation. This invention proposes a novel PCR reaction tube:

[0050] Reference Figure 3 In one embodiment, the reaction tube includes a container body 110 and a light-transmitting element 120. The container body 110 is provided with a liquid inlet, at least two notches 10a, and a flow channel 10b connecting the liquid inlet and the at least two notches 10a. The light-transmitting element 120 is disposed at the notch 10a of the container body 110 and surrounds the notch 10a to form at least two detection holes 111.

[0051] In this embodiment, the reaction tube may further include a cap 130, which is screwed onto the liquid inlet of the container body 110. The container body 110 and the cap 130 may be made of medical-grade plastic material, and the light-transmitting element 120 may be made of medical-grade PPMA, PC, etc., which is not limited here.

[0052] In this embodiment, there are preferably seven notches 10a, which can simultaneously meet the needs of nucleic acid detection for 21 pathogens. The notches 10a are all opened at the edge of the container body 110 away from the liquid inlet and are evenly spaced.

[0053] During manufacturing, the light-transmitting element 120 and the container body 110 can be injection molded, the light-transmitting element 120 can also be snapped onto the container body 110, the light-transmitting element 120 can also be glued onto the container body 110, or the light-transmitting element 120 can be fused onto the container body 110.

[0054] It is understood that the present invention provides a reaction tube with multiple detection wells 111, which can meet the requirements of the reaction tube for simultaneous detection of multiple pathogen nucleic acids. The multiple detection wells 111 are set one-to-one with the detection optical channels of multiple detectors. During fluorescence detection, light passes through the light-transmitting element 120 and shines on the nucleic acid of the sample to be tested in the detection well 111. It can simultaneously complete the detection of 1 to 21 pathogen nucleic acids, greatly improve the detection efficiency, significantly shorten the time of pathogen nucleic acid detection, significantly improve convenience, and greatly shorten the diagnostic cycle.

[0055] To save materials and facilitate processing, while simultaneously meeting the needs for nucleic acid detection of multiple pathogens, refer to Figure 3 In one embodiment, the container body 110 may include a circular tube 11 and a flow divider 12 integrally formed with the circular tube 11. The liquid inlet is located at one end of the circular tube 11, and the flow channel 10b and the notch 10a are located on the flow divider 12.

[0056] In this embodiment, the light-transmitting element 120 can be U-shaped to simultaneously surround all the gaps 10a, facilitating assembly and providing better sealing. Of course, in some other embodiments, multiple light-transmitting elements can be used to seal the multiple gaps 10a on the edge of the diverter plate 12 respectively; the number and shape of the light-transmitting elements 120 are not limited here.

[0057] In addition, to improve the stability of the electric gripper of the detector in holding the reaction tube, refer to Figures 1 to 3 In some embodiments, the circular tube 11 is provided with a protrusion 112 extending radially thereon, and when the electric gripper clamps, the protrusion 112 of the reaction tube is inserted into the corresponding socket of the electric gripper.

[0058] In this embodiment, a detection optical channel is provided at the detection hole 111 corresponding to the reaction tube within the detection slot 301. This arrangement allows for the simultaneous detection of 1 to 21 pathogen nucleic acids, significantly improving detection efficiency, greatly shortening the detection time, enhancing convenience, and ensuring the accuracy of the detection results.

[0059] In summary, the nucleic acid POCT detection instrument of the present invention has at least the following beneficial effects:

[0060] The nucleic acid POCT detection instrument of the present invention is fully automated from sample loading to result reporting, requiring no professional personnel to operate. In addition to being suitable for use in hospitals, it can also be used in non-medical institutions such as communities, airports, docks, and customs, and even in homes.

[0061] The nucleic acid POCT detection instrument of the present invention has multiple compartments and can simultaneously detect 1 to 4 samples or more. It can perform multi-channel simultaneous detection and the detection time is 15 to 30 minutes, making it the fastest instrument for pathogen nucleic acid detection at present.

[0062] The nucleic acid POCT detection instrument of the present invention is based on an original structural design and core algorithm, which can achieve rapid heating and cooling, rapid and accurate constant temperature, and photoelectric signal noise reduction and amplification, achieving high integration, high automation, and infinitely miniaturized size.

[0063] This invention relates to a nucleic acid POCT detector with multiple detection channels, capable of simultaneously detecting one to multiple samples. Employing technologies such as rapid heating and cooling, rapid and precise temperature control, and photoelectric signal noise reduction and amplification, it achieves high integration, high automation, and minimal size. It can automatically complete the entire process from sample to result within 30 minutes, detecting nucleic acids for 1 to 21 pathogens, and can print and send the results. Compared to traditional fluorescent PCR methods, the detection time is significantly reduced, convenience is greatly improved, and requirements for professional personnel and facilities are very low, thus its applicability is very wide.

[0064] This invention's nucleic acid POCT detection instrument integrates sample addition, nucleic acid extraction, and PCR amplification detection. After the original sample tube is loaded and the system is started, it automatically scans the barcode, opens / closes the cap, adds the sample, extracts the sample, constructs the PCR reaction system, closes the cap, centrifuges to remove bubbles, loads the sample, and performs detection. Results are available in 15-30 minutes and automatically transmitted, significantly reducing detection time. This nucleic acid POCT detection instrument can automatically detect pathogens in samples in a short time, greatly improving the diagnosis and treatment or prevention of infectious diseases, providing a new method to reduce medical costs, contributing to health strategies, and further enhancing the competitiveness of molecular diagnostic products.

[0065] The above description is merely an optional embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A nucleic acid POCT detection instrument, characterized in that, Includes a support platform and at least one detection device disposed on the support platform, wherein each detection device includes: The consumables compartment is located on the support platform and has a reagent tank holding position for placing reagent tanks, a sample tube holding position for placing sample tubes, and a reaction tube holding position for placing reaction tubes. The sample tube holding position is formed by a second gripper located on the support platform. The second gripper is connected to a fifth driving mechanism, which drives the second gripper to open and close. A mobile robotic arm module is mounted on the support platform and includes a magnetic rod mounting position, a suction nozzle mounting position, and a first gripper for clamping the reaction tube and / or the sample tube and opening / closing its cap. The mobile robotic arm module includes a slide rail, a slider, a second drive mechanism, a third drive mechanism, a fourth drive mechanism, a magnetic rod mounting block, a sixth drive mechanism, a suction nozzle mounting block, and a seventh drive mechanism. The slider is slidably mounted on the slide rail and driven by the second drive mechanism, which drives the slider to slide. The first gripper is mounted on the slider and driven by the third drive mechanism and the seventh drive mechanism. The fourth driving mechanism is respectively driven and connected; the third driving mechanism is used to drive the first gripper to open and close; the fourth driving mechanism is used to drive the first gripper to rotate to open / close the cover; the magnetic rod is located on the magnetic rod mounting block, the magnetic rod mounting block is vertically and vertically mounted on the slider and driven and connected to the sixth driving mechanism, the sixth driving mechanism is used to drive the magnetic rod mounting block to move up and down; the suction nozzle is located on the suction nozzle mounting block, the suction nozzle mounting block is vertically and vertically mounted on the slider and driven and connected to the seventh driving mechanism, the seventh driving mechanism is used to drive the suction nozzle mounting block to move up and down; and An amplification and detection module is mounted on the support platform and has a detection slot for accommodating the reaction tube. The amplification and detection module is used to amplify nucleic acids in the sample to be tested and perform real-time fluorescence detection.

2. The nucleic acid POCT detection instrument as described in claim 1, characterized in that, The detection device further includes a first driving mechanism, which is drivenly connected to the consumables compartment and used to drive the consumables compartment to slide in and out relative to the support platform.

3. The nucleic acid POCT detection instrument as described in claim 1, characterized in that, The detection slot is provided with a movable light-blocking component. The first gripper is also used to grip or push the movable light-blocking component and move the movable light-blocking component under the drive of the second drive mechanism.

4. The nucleic acid POCT detection instrument as described in claim 1, characterized in that, The consumables compartment also includes a consumables rack, which is mounted on the support platform and has several magnetic rod slots for placing the magnetic rods and several nozzle slots for placing the nozzles.

5. The nucleic acid POCT detection instrument as described in claim 1, characterized in that, The detection device also includes a heating element, which is located at the bottom of the reagent tank and is used to heat and amplify the sample to be tested.

6. The nucleic acid POCT detection instrument according to any one of claims 1 to 5, characterized in that, The nucleic acid POCT detector also includes a barcode scanner, which is located on the support platform and close to the sample tube receiving position. The barcode scanner is used to identify the sample information of the sample tube.

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