Mixing device based on hereditary deafness gene detection

Abstract

A disclosed blending device based on hereditary hearing loss gene detection comprises a box body, a rotating disc and a conversion assembly, the conversion assembly comprises a moving groove formed in the box body, a sliding column coaxially connected with the bottom end of the rotating disc is slidably clamped in the moving groove, a guide groove is formed in the bottom end of the sliding column, and a suspension is arranged at the top end of the inner wall of the box body; a first bevel gear is rotationally clamped at the bottom end of the suspension, a motor is arranged on the inner bottom wall of the box body, the output shaft end of the motor is coaxially connected with a second bevel gear through a coupler, the first bevel gear is meshed with the second bevel gear, the top end of the first bevel gear is coaxially connected with a guide plate, the guide plate is clamped in the guide groove, and a controller arranged on the suspension can drive the sliding column to move. The conversion assembly arranged in the device can be used in cooperation with the rotating disc, so that the device can achieve vortex oscillation and centrifugal oscillation at the same time, and when the oscillation mode needs to be adjusted, the controller drives the sliding column to move in the moving groove, and the position relation between the sliding shaft and the axis of the first bevel gear is changed.

Description

Technical Field

[0001] The present invention relates to the technical field of gene detection, and more specifically, to a mixing device based on hereditary deafness gene detection. Background Art

[0002] Hereditary deafness refers to deafness caused by gene and chromosomal abnormalities. This disease is caused by changes in the genetic material of parents and is passed on to offspring, and appears in a certain number of grandchildren. Current non-invasive prenatal tests usually screen for this common genetic disease by drawing blood for genetic testing.

[0003] However, existing genetic testing methods usually use a vortex oscillator to oscillate and mix the sample tube when mixing the sample. The oscillation of the sample tube is achieved by eccentric rotation of the oscillation plate. However, during the oscillation process, the tester needs to pinch the top of the sample tube by hand. At the same time, after oscillating with the vortex oscillator, a centrifuge is required for further mixing, which reduces the detection efficiency. Summary of the invention

[0004] The present invention provides a mixing device based on hereditary deafness gene detection to solve the problem that in the prior art gene detection methods, when mixing samples, a vortex oscillator is usually used to oscillate and mix the sample tube, but the detection personnel need to pinch the top of the sample tube by hand during the oscillation process, and after oscillating with the vortex oscillator, a centrifuge is needed to further mix the sample tube, thereby reducing the detection efficiency.

[0005] In order to achieve the above object, the present invention provides the following technical solutions:

[0006] A mixing device based on genetic detection of hereditary deafness includes a housing, a rotating disk and a conversion component, wherein the conversion component includes a moving groove opened on the housing, a sliding column coaxially connected to the bottom end of the rotating disk is slidably clamped in the moving groove, a guide groove is opened at the bottom end of the sliding column, a suspension is provided at the top end of the inner wall of the housing, a first bevel gear is rotatably clamped at the bottom end of the suspension, a motor is provided on the inner bottom wall of the housing, a second bevel gear is coaxially connected to the output shaft end of the motor through a coupling, the first bevel gear and the second bevel gear are meshed, a guide plate is coaxially connected to the top end of the first bevel gear, the guide plate is clamped in the guide groove, and a controller provided on the suspension can drive the sliding column to move.

[0007] Preferably, a limiting groove is coaxially provided on the top of the rotating disk, an inclination angle is arranged on the outer side of the top of the rotating disk, and clamps are evenly arranged on the inclination angle surface.

[0008] Preferably, the rear end of the box body is rotatably connected to a connecting frame, and the connecting frame is connected to a cantilever through a folding component. The folding component includes slots opened on both sides of the connecting frame, and limit plates are slidably clamped in the two slots. The two limit plates are connected by a pressing frame, and the cantilever is hinged to a fixed axis set at the top of the connecting frame, and the two limit plates are clamped at the bottom end of the cantilever.

[0009] Preferably, a limiting assembly is arranged between the connecting frame and the limiting plate, the limiting assembly includes side plates connected to the outer sides of the limiting plate, magnetic blocks are arranged on both sides of the connecting frame, and support arms are rotatably connected to both ends of the connecting frame, one end of the two support arms are respectively attracted to the bottom ends of the two magnetic blocks, the side plate and the support arms are arranged on the same vertical line, and a locking block is connected to one end of the hinge axis of the connecting frame and the box body through an elastic plate, and a locking groove is opened on the connecting frame, the locking block is clamped in the locking groove, and the locking block and the pressure frame are located in the same vertical direction.

[0010] Preferably, an elastic ring is provided at one end of the cantilever, a sample tube is clamped on the inner side of the elastic ring, three connecting blocks are provided at the bottom of one end of the cantilever, the bottom ends of the three connecting blocks are connected to splints through damping hinges, and the bottom ends of the splints are in contact with the outer wall of the sample tube.

[0011] Preferably, a pair of brackets are provided at the top of the cantilever, a pressure plate is connected between the two brackets via a pair of coil springs, a friction button is provided at the bottom end of the pressure plate, and the bottom end of the friction button is in contact with the top cover of the sample tube.

[0012] The principle and beneficial effects of this technical solution:

[0013] (1) The conversion assembly provided in the present invention can be used in conjunction with the rotating disk, so that the device can simultaneously realize vortex oscillation and centrifugal oscillation. When vortex oscillation is required, the slide column is driven to move in the moving groove through the controller, and the rotating disk coaxially connected to the slide column will move synchronously. At the same time, since the guide plate provided at the bottom end of the slide column is coaxially connected to the first bevel gear through the guide groove, when the slide shaft and the axis of the first bevel gear are not colinear, the sample tube is first clamped on the cantilever, and then the motor is started, and the second bevel gear connected to the output shaft end of the motor will drive the first bevel gear to rotate, so that the first gear rotates on the suspension, thereby driving the rotating disk coaxially connected to the slide shaft to rotate eccentrically;

[0014] When centrifugal oscillation is required, the controller drives the slide column to move in the moving groove until the slide shaft is in line with the axis of the first bevel gear. After the sample tube is fixed to the outside of the inclination angle of the outer periphery of the rotating disk by a clamp, the motor is started and the rotating disk is driven by the motor to rotate, causing the sample tube to undergo centrifugal oscillation.

[0015] (2) The limiting assembly provided in the present invention can lock the position of the limiting plate and the connecting frame in the folding assembly so that the cantilever can fix and support the sample tube, thereby reducing the amount of operation required by the inspector. When it is necessary to fold the connecting frame and the cantilever, the pressing frame is pressed down with force so that the pressing frame compresses the elastic plate at the bottom end of the locking block until the top end of the locking block is tangent to the outer edge of the hinge shaft between the connecting frame and the box body. At this time, the rotation restriction of the connecting frame is also released, and the connecting frame is rotated to the horizontal direction, and the cantilever is rotated 180 degrees to complete the folding of the connecting frame and the cantilever.

[0016] (3) The cantilever provided in the present invention can support the sample tube, replacing manual gripping of the top of the sample tube for vortex oscillation. When vortex oscillation is required, first lift the pressure plate connected by the coil spring between the two brackets, then insert the sample tube into the elastic ring, clamp the sample tube by the clamping plate, and then release the pressure plate so that the friction button at the bottom of the pressure plate is pressed into contact with the top cover of the sample tube, thereby fixing the rotation center of the sample tube to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 It is a schematic diagram of the structure after the present invention is split;

[0019] Figure 3 for Figure 2 Schematic diagram of the enlarged structure of the A area in the middle;

[0020] Figure 4 for Figure 2 Schematic diagram of the enlarged structure of the middle B area;

[0021] Figure 5 It is a schematic diagram of the structure after cutting of the present invention;

[0022] Figure 6 for Figure 5 Schematic diagram of the enlarged structure of the middle C area;

[0023] The figure marks in the drawings of the specification include: 1, box body; 2, sample tube; 3, limit groove; 4, connecting frame; 5, rotating disk; 6, guide groove; 7, sliding column; 8, coil spring; 9, bracket; 10, cantilever; 11, connecting block; 12, pressure plate; 13, friction button; 14, elastic ring; 15, clamping plate; 16, limit plate; 17, side plate; 18, magnetic block; 19, support arm; 20, slot; 21, pressure frame; 22, fixed shaft; 23, locking slot; 24, locking block; 25, elastic plate; 26, controller; 27, suspension; 28, movable slot; 29, guide plate; 30, first bevel gear; 31, second bevel gear; 32, motor. DETAILED DESCRIPTION

[0024] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments:

[0025] Example:

[0026] like Figures 1 to 6 As shown, the present invention provides a mixing device based on hereditary deafness gene detection, including a housing 1, a rotating disk 5 and a conversion component, the conversion component including a moving groove 28 opened on the housing 1, a sliding post 7 coaxially connected to the bottom end of the rotating disk 5 is slidably clamped in the moving groove 28, a guide groove 6 is opened at the bottom end of the sliding post 7, a suspension 27 is arranged at the top end of the inner wall of the housing 1, a first bevel gear 30 is rotatably clamped at the bottom end of the suspension 27, a motor 32 is arranged on the inner bottom wall of the housing 1, an output shaft end of the motor 32 is coaxially connected to a second bevel gear 31 through a coupling, the first bevel gear 30 and the second bevel gear 31 are meshed, a guide plate 29 is coaxially connected to the top end of the first bevel gear 30, the guide plate 29 is clamped in the guide groove 6, and a controller 26 arranged on the suspension 27 can drive the sliding post 7 to move.

[0027] like Figure 1 and Figure 2 As shown, a limiting groove 3 is coaxially provided at the top of the rotating disk 5, an inclination angle is arranged at the outer side of the top of the rotating disk 5, and clamps are evenly arranged on the inclination angle surface.

[0028] like Figures 1 to 4 As shown, the rear end of the box body 1 is rotatably connected to the connecting frame 4, and the connecting frame 4 is connected to the cantilever 10 through a folding assembly. The folding assembly includes slots 20 opened on both sides of the connecting frame 4, and limit plates 16 are slidably clamped in the two slots 20. The two limit plates 16 are connected by a pressing frame 21. The cantilever 10 is hinged to the fixed axis 22 set at the top of the connecting frame 4, and the two limit plates 16 are clamped at the bottom of the cantilever 10.

[0029] like Figure 1 , Figure 4 and Figure 5 As shown, a limiting assembly is arranged between the connecting frame 4 and the limiting plate 16, and the limiting assembly includes a side plate 17 connected to the outside of the limiting plate 16, and magnetic blocks 18 are arranged on both sides of the connecting frame 4. Support arms 19 are rotatably connected to both ends of the connecting frame 4, and one end of the two support arms 19 is respectively attracted to the bottom ends of the two magnetic blocks 18, and the side plate 17 and the support arms 19 are arranged on the same vertical straight line. One end of the hinge axis of the connecting frame 4 and the box body 1 is connected with a locking block 24 through an elastic plate 25. A locking groove 23 is opened on the connecting frame 4, and the locking block 24 is clamped in the locking groove 23. The locking block 24 and the pressing frame 21 are located in the same vertical direction.

[0030] The limiting assembly can lock the position of the limiting plate 16 and the connecting frame 4 in the folding assembly so that the cantilever 10 can fix and support the sample tube 2, thereby reducing the amount of operation for the inspector; and after unlocking, the folding assembly can fold the connecting frame 4 and the limiting plate 16 to prevent the connecting frame 4 and the cantilever 10 from affecting the centrifugal oscillation of the sample tube 2. When the connecting frame 4 and the cantilever 10 need to be folded, the pressing frame 21 is pressed down with force, and the limiting plates 16 connected at both ends of the pressing frame 21 will move downward together with the side plates 17 arranged on both sides thereof. At this time, the limiting plates 16 are no longer The card is set at the bottom end of the cantilever 10, and the cantilever 10 releases the rotation restriction. Continue to press down the press frame 21, so that the side plate 17 squeezes the support arm 19, and the support arm 19 is separated from the attraction with the magnetic block 18. At this time, continue to press down the press frame 21, so that the press frame 21 compresses the elastic plate 25 at the bottom end of the locking block 24 until the top of the locking block 24 is tangent to the outer edge of the hinge axis of the connecting frame 4 and the box body 1. At this time, the connecting frame 4 is also released from the rotation restriction, and the connecting frame 4 is rotated to the horizontal direction. The cantilever 10 is rotated 180 degrees to complete the folding of the connecting frame 4 and the cantilever 10.

[0031] like Figure 1 and Figure 3 As shown, an elastic ring 14 is provided at one end of the cantilever 10, and a sample tube 2 is clamped on the inner side of the elastic ring 14. Three connecting blocks 11 are provided at the bottom of one end of the cantilever 10. The bottom ends of the three connecting blocks 11 are connected to a splint 15 through a damping hinge, and the bottom end of the splint 15 contacts the outer wall of the sample tube 2.

[0032] like Figure 1 and Figure 3 As shown, a pair of brackets 9 are arranged at the top of the cantilever 10, a pressure plate 12 is connected between the two brackets 9 via a pair of coil springs 8, a friction button 13 is arranged at the bottom end of the pressure plate 12, and the bottom end of the friction button 13 contacts the top cover of the sample tube 2.

[0033] The cantilever 10 can support the sample tube 2, replacing manual gripping of the top of the sample tube 2 for vortex oscillation. When vortex oscillation is required, first lift the pressure plate 12 connected by the coil spring 8 between the two brackets 9, then insert the sample tube 2 into the elastic ring 14, clamp the sample tube 2 by the clamping plate 15, and then release the pressure plate 12 so that the friction button 13 at the bottom end of the pressure plate 12 is in contact with the top cover of the sample tube 2, thereby fixing the rotation center of the sample tube 2 to a certain extent.

[0034] The specific usage and function of this embodiment are as follows:

[0035] The conversion assembly provided in the present invention can be used in conjunction with the rotating disk 5, so that the device can simultaneously realize vortex oscillation and centrifugal oscillation. When vortex oscillation is required, the controller 26 drives the slide post 7 to move in the moving groove 28, and the rotating disk 5 coaxially connected to the slide post 7 will move synchronously. At the same time, since the guide plate 29 provided at the bottom end of the slide post 7 is coaxially connected to the first bevel gear 30 through the guide groove 6, when the axis of the slide shaft and the first bevel gear 30 are not colinear, the sample tube 2 is first clamped onto the cantilever 10, and then the motor is started, and the second bevel gear 31 connected to the output shaft end of the motor will drive the first bevel gear 30 to rotate, so that the first gear rotates on the suspension 27, thereby driving the rotating disk 5 coaxially connected to the slide shaft to rotate eccentrically;

[0036] When centrifugal oscillation is required, the controller 26 drives the slide column 7 to move in the movable groove 28 until the slide shaft is in line with the axis of the first bevel gear 30. After the sample tube 2 is fixed to the outside of the inclination angle of the outer periphery of the rotating disk 5 by a clamp, the motor is started, and the rotating disk 5 will rotate driven by the motor, so that the sample tube 2 is centrifugally oscillated.

[0037] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A mixing device based on hereditary deafness gene detection, characterized in that: The invention comprises a housing (1), a rotating disk (5) and a conversion assembly, wherein the conversion assembly comprises a movable groove (28) provided on the housing (1), a sliding column (7) coaxially connected to the bottom end of the rotating disk (5) and slidably clamped in the movable groove (28), a guide groove (6) provided at the bottom end of the sliding column (7), a suspension (27) provided at the top end of the inner wall of the housing (1), a first bevel gear (30) rotatably clamped at the bottom end of the suspension (27), a motor (32) provided on the inner bottom wall of the housing (1), an output shaft end of the motor (32) coaxially connected to a second bevel gear (31) through a coupling, the first bevel gear (30) and the second bevel gear (31) meshing, a guide plate (29) coaxially connected to the top end of the first bevel gear (30), the guide plate (29) clamped in the guide groove (6), and a controller (26) provided on the suspension (27) can drive the sliding column (7) to move.

2. A mixing device based on hereditary deafness gene detection according to claim 1, characterized in that: A limiting groove (3) is coaxially provided at the top end of the rotating disk (5), an inclination angle is arranged on the outer side of the top end of the rotating disk (5), and clamps are evenly arranged on the inclination angle surface.

3. A mixing device based on hereditary deafness gene detection according to claim 2, characterized in that: The rear end of the box body (1) is rotatably connected to a connecting frame (4), and the connecting frame (4) is connected to a cantilever (10) through a folding assembly. The folding assembly includes slots (20) opened on both sides of the connecting frame (4), and limit plates (16) are slidably clamped in the two slots (20). The two limit plates (16) are connected by a pressing frame (21). The cantilever (10) is hinged to a fixed shaft (22) arranged at the top end of the connecting frame (4), and the two limit plates (16) are clamped at the bottom end of the cantilever (10).

4. A mixing device based on hereditary deafness gene detection according to claim 3, characterized in that: A limiting assembly is arranged between the connecting frame (4) and the limiting plate (16), and the limiting assembly comprises a side plate (17) connected to the outer side of the limiting plate (16). Magnetic blocks (18) are arranged on both sides of the connecting frame (4). Support arms (19) are rotatably connected to both ends of the connecting frame (4). One end of the two support arms (19) is respectively attracted to the bottom ends of the two magnetic blocks (18). The side plate (17) and the support arms (19) are arranged on the same vertical straight line. A locking block (24) is connected to one end of the hinge shaft between the connecting frame (4) and the box body (1) through an elastic plate (25). A locking groove (23) is provided on the connecting frame (4). The locking block (24) is clamped in the locking groove (23). The locking block (24) and the pressing frame (21) are located in the same vertical direction.

5. A mixing device based on hereditary deafness gene detection according to claim 4, characterized in that: An elastic ring (14) is provided at one end of the cantilever (10), and a sample tube (2) is clamped inside the elastic ring (14). Three connecting blocks (11) are provided at the bottom of one end of the cantilever (10), and the bottom ends of the three connecting blocks (11) are connected to a clamping plate (15) through a damping hinge, and the bottom end of the clamping plate (15) is in contact with the outer wall of the sample tube (2).

6. A mixing device based on hereditary deafness gene detection according to claim 5, characterized in that: A pair of brackets (9) are arranged at the top of the cantilever (10), a pressure plate (12) is connected between the two brackets (9) via a pair of coil springs (8), a friction button (13) is arranged at the bottom end of the pressure plate (12), and the bottom end of the friction button (13) is in contact with the top cover of the sample tube (2).

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