A method for testing the swelling degree of carbomer gel

Abstract

The present application provides a method for testing the swelling degree of carbomer gel. By testing the swelling degree of carbomer gel in the same electrolyte and solvents with different concentrations, the first swelling degree corresponding to each selected sol is obtained; based on all the first swelling degrees, the contribution degree of the hydrophilicity of carbomer gel to the change in swelling degree is determined; the swelling degree of carbomer gel is tested in different electrolytes and solvents with different concentrations to obtain the second swelling degree corresponding to each selected sol; based on all the second swelling degrees, the amount of solvent wrapped by the molecular chains in carbomer gel under unit ionic strength is determined; according to the contribution degree and the wrapped amount, the swelling responsiveness of the swelling degree of carbomer gel to the change in ionic strength in the solvent is determined, and the swelling degree test result is generated based on the swelling responsiveness. By adopting the solution of the present application, a transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent can be established, thereby improving the versatility of the swelling degree test result of carbomer gel.

Description

Technical Field

[0001] The present application relates to the technical field of compatibility testing, and more specifically, to a method for testing the swelling degree of carbomer gel. Background Art

[0002] Compatibility testing is a common experimental method mainly used to determine whether different materials, chemical substances, components or systems can be compatible with each other in a certain environment without adverse reactions or failures. Such tests are widely used in many fields, including pharmaceuticals, chemical engineering, food science, materials science, biology, etc.

[0003] The swelling degree test of the gel is one of the compatibility tests of the gel. When evaluating the interaction between the gel material and the solvent or other environmental factors (such as temperature, pH value, ion concentration, etc.), the swelling degree test helps to evaluate the compatibility of the gel material in different media. In the prior art, the swelling degree of carbomer gel is usually tested by the gravimetric method, the volumetric method and the image analysis method. However, these three methods only detect the swelling degree of carbomer gel in a certain specific solvent. In the actual application of carbomer gel, carbomer gel will contact solvents with various different ionic strengths, which results in the lack of universality of the existing carbomer gel swelling degree test methods. Therefore, how to establish the transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, and then improve the universality of the carbomer gel swelling degree test results has become a difficult problem faced by the industry. Summary of the Invention

[0004] The present application provides a method for testing the swelling degree of carbomer gel, which can establish the transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, and then improve the universality of the carbomer gel swelling degree test results.

[0005] In the first aspect, the present application provides a method for testing the swelling degree of carbomer gel, and the method includes:

[0006] Preparing a sample of carbomer gel and preparing the test equipment required for the test, and the test equipment includes a centrifuge and an intelligent sensor;

[0007] Performing a first swelling degree test on the sample of carbomer coagulant with the same electrolyte and solvents with different concentrations through the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor;

[0008] Determining the order of change of the free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determining the contribution degree of the hydrophilicity of the carbomer gel to the change of the swelling degree according to the order of change;

[0009] The sample of the carbomer coagulant is subjected to a second swelling degree test under different electrolytes and solvents with different concentrations by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected based on the intelligent sensor;

[0010] Based on all the second swelling degrees, the non-linear deviation caused by the cross-linking degree of the carbomer gel on the change of the swelling degree of the carbomer gel is determined, and then the amount of solvent wrapped by the molecular chains in the carbomer gel under unit ionic strength is determined according to the non-linear deviation;

[0011] The swelling responsiveness of the carbomer gel swelling degree to the change of ionic strength in the solvent is determined according to the contribution degree and the amount of wrapping, and the swelling degree test result is generated based on the swelling responsiveness.

[0012] In some embodiments, preparing a sample of the carbomer gel means taking any weight of the carbomer gel and drying it in an oven for a preset period, and using the dried carbomer gel as the sample of the carbomer gel.

[0013] In some embodiments, the first swelling degree test of the carbomer gel sample under the same electrolyte and solvents with different concentrations by the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor specifically includes:

[0014] Select an electrolyte, and prepare multiple solvents with different electrolyte concentrations according to the electrolyte;

[0015] Select a solvent as the first selected solvent;

[0016] Weigh the sample of the carbomer gel through the intelligent sensor to obtain the first sample mass;

[0017] Add the sample of the carbomer gel and the first selected solvent into a dry centrifuge tube and stir;

[0018] Put the stirred centrifuge tube into the centrifuge for centrifugation;

[0019] Tilt and let stand the centrifuge tube after centrifugation, then remove the upper-layer solvent in the centrifuge tube, and weigh the centrifuge tube after removing the upper-layer solvent through the intelligent sensor to obtain the first test mass;

[0020] Determine the first swelling degree corresponding to the first swelling degree test of the first selected solvent according to the first sample mass and the first test mass;

[0021] Select the remaining other solvents, and continue to obtain the first swelling degrees corresponding to the first swelling degree tests of the remaining solvents.

[0022] In some embodiments, determining the order of change in free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees specifically includes:

[0023] Convert all the first swelling degrees into a first swelling degree sequence;

[0024] Determine the first difference sequence of the first swelling degree sequence;

[0025] Determine the change amount of free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence;

[0026] Determine the order of change in free energy related to the hydrophilicity of the carbomer gel according to the change amounts of all free energies.

[0027] In some embodiments, determining the change amount of free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence specifically includes:

[0028] Preset the offset coefficients of multiple solvent solubilities, and determine the solubility offset sequences corresponding to each offset coefficient according to each offset coefficient and the first difference sequence;

[0029] Determine the change amount of free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to all the solubility offset sequences.

[0030] In some embodiments, determining the contribution degree of the hydrophilicity of the carbomer gel to the change in swelling degree according to the order of change specifically includes:

[0031] Construct a fitting model for the first swelling degree test according to the order of change;

[0032] Fit all the first swelling degrees and the concentration of the solvent corresponding to each first swelling degree according to the fitting model, and further obtain the contribution degree of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0033] In some embodiments, performing a second swelling degree test on the carbomer gel sample under different electrolytes and solvents with different concentrations by the centrifuge, and detecting the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor specifically includes:

[0034] Select a variety of electrolytes, and prepare multiple solvents with different electrolytes and different concentrations according to all the electrolytes;

[0035] Select one solvent as the second selected solvent;

[0036] Weigh the carbomer gel sample by the intelligent sensor to obtain the second sample mass;

[0037] Add the sample of carbomer gel and the second selected solvent to a dry centrifuge tube and stir;

[0038] Place the stirred centrifuge tube in a centrifuge for centrifugation;

[0039] Tilt and let stand the centrifuge tube after centrifugation, then remove the upper layer of solvent in the centrifuge tube, and weigh the centrifuge tube after removing the upper layer of solvent through the intelligent sensor to obtain the second test mass;

[0040] Determine the second swelling degree corresponding to the second swelling degree test of the second selected solvent according to the second sample mass and the second test mass;

[0041] Select the remaining other solvents, and continue to obtain the second swelling degrees corresponding to the second swelling degree tests of the remaining solvents.

[0042] In some embodiments, the centrifuge is a floor-standing low-speed electric centrifuge.

[0043] In some embodiments, the intelligent sensor is an integrated sensor for weighing and temperature measurement.

[0044] In some embodiments, generating the swelling degree test result based on the swelling responsiveness means drawing a swelling degree curve graph of the carbomer gel according to the swelling responsiveness, and using the swelling degree curve graph as the swelling degree test result.

[0045] The technical solutions provided by the embodiments disclosed in this application have the following beneficial effects:

[0046] In the carbomer gel swelling degree test method provided by this application, first, by preparing a sample of carbomer gel and preparing the test equipment required for the test, the test equipment includes a centrifuge and an intelligent sensor; performing a first swelling degree test on the sample of carbomer coagulant under the same electrolyte and different concentration solvents through the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor; determining the change order of the free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and further determining the contribution degree of the hydrophilicity of the carbomer gel to the change in the swelling degree according to the change order; performing a second swelling degree test on the sample of carbomer coagulant under different electrolytes and different concentration solvents through the centrifuge, and detecting the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor; determining the non-linear deviation caused by the cross-linking degree of the carbomer gel to the change in the swelling degree of the carbomer gel based on all the second swelling degrees, and further determining the amount of molecular chains in the carbomer gel wrapping the solvent under the unit ionic strength according to the non-linear deviation; determining the swelling responsiveness of the carbomer gel swelling degree to the change in the ionic strength in the solvent according to the contribution degree and the wrapping amount, and generating the swelling degree test result based on the swelling responsiveness.

[0047] It can be seen that in this application, the swelling degree of carbomer gel is tested under the same electrolyte and solvents with different concentrations, and then, based on the change characteristics of the test results (i.e., the order of change of free energy), the contribution of the hydrophilicity of carbomer gel to the change of swelling degree is evaluated; subsequently, the swelling degree of carbomer gel is tested with different electrolytes and solvents with different concentrations, and the non-linear deviation of the cross-linking degree of carbomer gel from the change of swelling degree of carbomer gel under solvents with different molecular weights is obtained. Then, based on this non-linear deviation, the amount of aqueous solution wrapped by the molecular chains in carbomer gel under unit ionic strength is determined. Finally, based on this contribution and the amount of wrapping, the non-linear characteristics of the swelling degree of carbomer gel changing with ionic strength are determined. Furthermore, based on this non-linear characteristic, the swelling responsiveness of carbomer gel to the change of ionic strength in the solvent is fitted, and the final swelling degree test result is generated based on the swelling responsiveness. To sum up, this application can establish the transfer relationship between the swelling degree of carbomer gel and the ionic strength in the solvent, thereby improving the versatility of the test results of the swelling degree of carbomer gel. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 is an exemplary flowchart of a method for testing the swelling degree of carbomer gel according to some embodiments of the present application;

[0049] Figure 2 is a schematic structural diagram of a centrifuge according to some embodiments of the present application;

[0050] Figure 3 is an exemplary flowchart of a first swelling degree test according to some embodiments of the present application;

[0051] Figure 4 is an exemplary flowchart for determining the swelling responsiveness according to some embodiments of the present application

[0052] Figure 5 is a swelling degree curve graph of carbomer gel according to some embodiments of the present application;

[0053] Figure 6 is a schematic structural diagram of a device for testing the swelling degree of carbomer gel according to some embodiments of the present application. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0054] In order to better understand the technical solution of the present application, the technical solution of the present application will be described in detail below in conjunction with the drawings in the specification and specific embodiments.

[0055] Reference Figure 1, This figure is an exemplary flowchart of a method for testing the swelling degree of carbomer gel according to some embodiments of the present application. The method 100 for testing the swelling degree of carbomer gel mainly includes the following steps:

[0056] In step 101, a sample of carbomer gel is prepared, and the test equipment required for the test is prepared. The test equipment includes a centrifuge and an intelligent sensor.

[0057] In some embodiments, preparing a sample of carbomer gel means taking any weight of carbomer gel and drying it in an oven for a preset period, and using the dried carbomer gel as the sample of carbomer gel.

[0058] It should be noted that in the present application, the preset period is usually preset to any value not less than 24 hours. For example, in the present application, the preset period is preset to 24 hours. Those skilled in the art know that the preset period can also be preset to any other value not less than 24 hours, which all fall within the protection scope of the present invention and will not be elaborated here.

[0059] In some embodiments, refer to Figure 2 , This figure is a schematic structural diagram of a centrifuge according to some embodiments of the present application. The centrifuge is a floor-standing low-speed electric centrifuge, and specifically includes: a centrifuge body, a centrifuge console, a touch display screen, a positioning groove, a centrifuge drum, a machine cover, and a positioning iron pillar.

[0060] In some embodiments, the intelligent sensor is an integrated sensor for weighing and temperature measurement.

[0061] In specific implementation, preparing the test equipment required for the test can be achieved by the following method, that is: calibrating the zero point of the integrated sensor to eliminate the measurement error of the integrated sensor, and performing an unloaded low-speed test on the centrifuge to ensure the normal operation of the centrifuge.

[0062] In step 102, the sample of carbomer coagulant is subjected to a first swelling degree test under the same electrolyte and solvents with different concentrations by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected based on the intelligent sensor.

[0063] In some embodiments, refer to Figure 3 , This figure is an exemplary flowchart of the first swelling degree test according to some embodiments of the present application. In the present application, the sample of carbomer coagulant is subjected to a first swelling degree test under the same electrolyte and solvents with different concentrations by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected based on the intelligent sensor, which can be achieved by the following steps:

[0064] In step 1021, an electrolyte is selected, and solvents with multiple different electrolyte concentrations are prepared according to the electrolyte;

[0065] In step 1022, a solvent is selected as the first selected solvent;

[0066] In step 1023, the sample of carbomer gel is weighed by the intelligent sensor to obtain the first sample mass;

[0067] In step 1024, the sample of carbomer gel and the first selected solvent are added to a dry centrifuge tube and stirred;

[0068] In step 1025, the stirred centrifuge tube is placed in a centrifuge for centrifugation;

[0069] In step 1026, the centrifuged centrifuge tube is tilted and left standing, then the upper-layer solvent in the centrifuge tube is removed, and the centrifuge tube after removing the upper-layer solvent is weighed by the intelligent sensor to obtain the first test mass;

[0070] In step 1027, the first swelling degree corresponding to the first swelling degree test of the first selected solvent is determined according to the first sample mass and the first test mass;

[0071] In step 1028, the remaining solvents are selected, and the first swelling degrees corresponding to the first swelling degree tests of the remaining solvents are continuously obtained.

[0072] In specific implementation, the first swelling degree test of the carbomer coagulant sample under the same electrolyte and different concentration solvents is carried out by the centrifuge, and the first swelling degrees corresponding to each selected solvent during the first swelling degree test are detected based on the intelligent sensor. It can be implemented in the following manner: the sample of carbomer gel is weighed by the intelligent sensor, and the obtained mass is used as the first sample mass. The sample of carbomer gel is placed in a dry centrifuge tube. Subsequently, the first selected solvent is added to the dry centrifuge tube and stirred. After 15 minutes, it is stirred again, and 15 minutes after the secondary stirring, it is centrifuged at a preset centrifugal speed for 20 minutes. Then, the centrifuge tube is tilted to remove the upper-layer solvent, and the centrifuge tube together with the sample is weighed again. The obtained mass is used as the first test mass. The centrifugal speed can be preset according to actual needs. For example, in this application, the centrifugal speed can be preset to 4000 r / min.

[0073] In specific implementation, the first swelling degree corresponding to the first selected solvent for the first swelling degree test can be determined according to the first sample mass and the first test mass in the following manner: subtract the mass of the centrifuge tube from the first test mass, divide the obtained value by the first sample mass, and use the resulting quotient as the first swelling degree corresponding to the first selected solvent for the first swelling degree test. It should be noted that in this application, multiple solvents with the same electrolyte but different concentrations are prepared in advance. For example, ammonium chloride can be selected as the electrolyte in the solvent, and the concentrations of the solvent are preset to eight concentrations: 0.5 g / L, 1.0 g / L, 2.0 g / L, 5.0 g / L, 10.0 g / L, 25 g / L, 50 g / L, and 100 g / L.

[0074] It should be noted that in this application, "first" and "second" do not represent the order of precedence and do not limit the first swelling degree test of the carbomer gel. They are only used to distinguish the swelling degrees obtained from the two first swelling degree tests. For example, the "first" and "second" in the first swelling degree and the second swelling degree are only used to distinguish and indicate that these are the swelling degrees obtained from the first swelling degree tests of different processes.

[0075] In addition, it should be noted that in this application, the temperature inside the centrifuge tube during each first swelling degree test can be collected by the intelligent sensor, and the temperature during each first swelling degree test can be kept constant by the heating device and the cooling device.

[0076] In step 103, based on all the first swelling degrees, determine the order of change in free energy related to the hydrophilicity of the carbomer gel, and then determine the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree according to the order of change.

[0077] In some embodiments, the order of change in free energy related to the hydrophilicity of the carbomer gel can be determined based on all the first swelling degrees by the following steps:

[0078] Convert all the first swelling degrees into a first swelling degree sequence;

[0079] Determine the first difference sequence of the first swelling degree sequence;

[0080] Determine the change amount of free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence;

[0081] Determine the order of change in free energy related to the hydrophilicity of the carbomer gel according to the change amounts of all free energies.

[0082] In specific implementation, converting all the first swelling degrees into a first swelling degree sequence can be achieved in the following manner, that is: all the first swelling degrees can be sorted in ascending order according to the concentration of the solvent used in the first swelling degree test, and the obtained sorted sequence is used as the first swelling degree sequence.

[0083] In specific implementation, determining the first difference sequence of the first swelling degree sequence can be achieved in the following manner, that is: select two adjacent first swelling degrees in the first swelling degree sequence, subtract the earlier first swelling degree from the later one, and then use the obtained difference value as the difference value corresponding to the two selected first swelling degrees. Subsequently, select other adjacent two first swelling degrees in the first swelling degree sequence, and continue to obtain the difference values corresponding to each remaining pair of adjacent first swelling degrees. Finally, arrange all the obtained difference values in the arrangement order of the first swelling degrees in the first swelling degree sequence, and the obtained arranged sequence is used as the first difference sequence.

[0084] In some embodiments, determining the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence can be achieved through the following steps:

[0085] Preset offset coefficients for multiple solvent concentrations, and determine the solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first difference sequence;

[0086] Determine the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to all the solubility offset sequences.

[0087] It should be noted that the offset coefficient of the solvent concentration in the present application is a parameter used for offset comparison between the solvent concentration and the first swelling degree in the first swelling degree test. This offset comparison refers to comparing the first swelling degrees corresponding to different solvent concentrations, and this offset coefficient can be preset according to actual needs. For example, in the present application, this offset coefficient can be preset as 1, 2, 3, 4, and 5 respectively.

[0088] In specific implementation, determining the solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first difference sequence can be achieved in the following manner, that is: for each offset coefficient, add n zeros before the first difference value in the first difference sequence, and the obtained sequence is used as the solubility offset sequence corresponding to the offset coefficient, where n is the offset coefficient of the solvent concentration.

[0089] It should be noted that in this application, the solubility offset sequence refers to the sequence after the corresponding relationship between the difference value and the solvent concentration is offset. For example, for the solubility offset sequence with an offset coefficient of a, the b-th difference value in the first difference sequence corresponds to the (b + a)-th value in this solubility offset sequence, that is, each difference value is offset by a.

[0090] When specifically implemented, the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test can be determined according to all the solubility offset sequences in the following way: First, select a solubility offset sequence as the selected solubility offset sequence, subtract the average value of the first difference sequence from the first value in the selected solubility offset sequence, and use the obtained value as the first deviation of the selected solubility offset sequence. Subsequently, add i zeros after the last difference value in the first difference sequence to make the length of the added sequence equal to that of the selected solubility offset sequence, subtract the average value of the first difference sequence from the first difference value in the added sequence, and use the obtained value as the first deviation of the first difference sequence, and multiply the first deviation of the selected solubility offset sequence by the first deviation of the first difference sequence. Then, divide the obtained value by the variance of the first difference sequence, and use the obtained value after division as the change amount of the free energy related to the hydrophilicity of the carbomer gel in the first first swelling degree test. Finally, select the remaining solubility offset sequences as the selected solubility offset sequences, and repeat the above steps to obtain the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test.

[0091] It should be noted that the change amount of the free energy in this application is a parameter representing the degree of change in the free energy generated when the carbomer gel interacts with the solvent. The larger this change amount, the more free energy changes are generated when the carbomer gel interacts with the solvent in the first swelling degree test; the smaller this change amount, the less free energy changes are generated when the carbomer gel interacts with the solvent in the first swelling degree test.

[0092] When specifically implemented, the change order of the free energy related to the hydrophilicity of the carbomer gel can be determined according to all the change amounts of the free energy in the following way: First, arrange all the change amounts of the free energy in ascending order according to the size of the solvent concentration in the corresponding first swelling degree test. Then, compare each change amount with a preset change threshold in turn in the arranged sequence. If the k-th change amount is less than the preset change threshold for the first time, then use k as the change order of the free energy related to the hydrophilicity of the carbomer gel.

[0093] It should be noted that the change threshold is usually preset as a relatively small positive number. For example, the change threshold can be preset as 0.05. Those skilled in the art know that the change threshold can be preset as other values according to actual needs, and all fall within the protection scope of the present invention, and will not be elaborated here.

[0094] It should be noted that in this application, the order of change of free energy is a parameter representing the complexity of the change in the free energy of the carbomer gel during the swelling degree test with respect to the change in solvent concentration. The larger this order of change, the more complex the change in the free energy related to the hydrophilicity of the carbomer gel with respect to the change in solvent concentration during the first swelling degree test. The smaller this order of change, the less complex the change in the free energy related to the hydrophilicity of the carbomer gel with respect to the change in solvent concentration during the first swelling degree test.

[0095] In some embodiments, determining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree based on the order of change can be achieved by the following steps:

[0096] Construct a fitting model for the first swelling degree test according to the order of change;

[0097] Perform fitting on all the first swelling degrees and the concentrations of the solvents corresponding to each first swelling degree according to the fitting model, and then obtain the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0098] Specifically, constructing a fitting model for the first swelling degree test according to the order of change can be achieved in the following manner: select an autoregressive model in the prior art, and set the maximum order of the dependent variable in the autoregressive model to the same value as the order of change, and then use the obtained autoregressive model as the fitting model for the first swelling degree test.

[0099] Specifically, performing fitting on all the first swelling degrees and the concentrations of the solvents corresponding to each first swelling degree according to the fitting model, and then obtaining the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree can be achieved in the following manner: input all the first swelling degrees and the concentrations of the solvents corresponding to each first swelling degree into the fitting model for fitting, and use the intercept of the fitted function as the contribution of the hydrophilicity of the carbomer gel to the change in swelling degree.

[0100] It should be noted that in this application, the contribution degree is a parameter representing the degree of promotion of the hydrophilicity of the carbomer gel to the entry of water molecules in the solvent into the carbomer gel. The larger this contribution degree, the more the hydrophilicity of the carbomer gel promotes the entry of water molecules in the solvent into the carbomer gel during the first swelling degree test. The smaller this contribution degree, the less the hydrophilicity of the carbomer gel promotes the entry of water molecules in the solvent into the carbomer gel during the first swelling degree test.

[0101] In addition, it should be noted that the stronger the hydrophilicity of the carbomer gel, the easier the gel molecular chains are to interact with water molecules to form attractive forces such as hydrogen bonds. The greater this interaction, the more it will promote more water to enter the gel structure, increasing the swelling degree, that is, the greater the contribution of the hydrophilicity to the change in swelling degree.

[0102] In step 104, the sample of carbomer coagulant is subjected to a second swelling degree test under different electrolytes and solvents with different concentrations by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected based on the intelligent sensor.

[0103] In some embodiments, the sample of carbomer coagulant is subjected to a second swelling degree test under different electrolytes and solvents with different concentrations by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected based on the intelligent sensor, which can be realized by the following steps:

[0104] Select a variety of electrolytes and prepare multiple solvents with different electrolytes and different concentrations according to all the electrolytes;

[0105] Select one solvent as the second selected solvent;

[0106] Weigh the sample of carbomer gel by the intelligent sensor to obtain the second sample mass;

[0107] Add the sample of carbomer gel and the second selected solvent into a dry centrifuge tube and stir;

[0108] Put the stirred centrifuge tube into the centrifuge for centrifugation;

[0109] Tilt and let stand the centrifuge tube after centrifugation, then remove the upper-layer solvent in the centrifuge tube, and weigh the centrifuge tube after removing the upper-layer solvent by the intelligent sensor to obtain the second test mass;

[0110] Determine the second swelling degree corresponding to the second swelling degree test of the second selected solvent according to the second sample mass and the second test mass;

[0111] Select the remaining other solvents and continue to obtain the second swelling degree corresponding to the second swelling degree test of the remaining solvents.

[0112] When specifically implemented, the sample of carbomer coagulant is subjected to a second swelling degree test under different electrolytes and solvents with different concentrations by the centrifuge, which can be realized in the following way: First, weigh the sample of carbomer gel by the intelligent sensor, take the obtained mass as the second sample mass, place the sample of carbomer gel in a dry centrifuge tube, then add the second selected solvent into the dry centrifuge tube and stir. After 15 minutes, stir again, and after 15 minutes of the second stirring, centrifuge at a preset centrifugal speed for 20 minutes. Then, tilt the centrifuge tube, remove the upper-layer solvent, weigh the centrifuge tube again, and take the obtained mass as the second test mass. Among them, the centrifugal speed can be preset according to actual needs. For example, in this application, the centrifugal speed can be preset to 4000 r / min.

[0113] In specific implementation, the second swelling degree corresponding to the second selected solvent for the second swelling degree test can be determined according to the second sample mass and the second test mass in the following manner, that is: subtract the mass of the centrifuge tube from the second test mass, divide the obtained value by the second sample mass, and use the obtained quotient as the second swelling degree corresponding to the second selected solvent for the second swelling degree test.

[0114] It should be noted that different electrolytes and different concentration solvents in this application refer to multiple solvents prepared in advance. For example, in this application, six electrolytes with monovalent cations such as ammonium chloride, ammonium nitrate, potassium nitrate, potassium chloride, ammonium bicarbonate, and dipotassium hydrogen phosphate can be selected as the electrolytes in the solvent, and the concentrations of the solvents can be preset to eight concentrations of 0.5 g / L, 1.0 g / L, 2.0 g / L, 5.0 g / L, 10.0 g / L, 25 g / L, 50 g / L, and 100 g / L. That is, there are a total of 48 solvents with different electrolytes and different concentrations. In other embodiments, other electrolytes or solvents with other concentrations can also be used, which are not limited here.

[0115] In addition, it should be noted that "first" and "second" in this application do not represent the order of priority and do not limit the test operation either. They are only used to distinguish the swelling degrees obtained from two tests. For example, the first and second in the first swelling degree and the second swelling degree are only used to distinguish to indicate that these are the swelling degrees obtained from different test processes.

[0116] In addition, it should be noted that in this application, the temperature inside the centrifuge tube during each second swelling degree test can be collected by the intelligent sensor, and the temperature during each second swelling degree test can be kept constant by the heating device and the cooling device.

[0117] In step 105, based on all the second swelling degrees, determine the non-linear deviation caused by the cross-linking degree of the carbomer gel on the change of the carbomer gel swelling degree, and then determine the amount of solvent wrapped by the molecular chains in the carbomer gel at a certain ionic strength according to the non-linear deviation.

[0118] In some embodiments, determining the non-linear deviation caused by the cross-linking degree of the carbomer gel on the change of the carbomer gel swelling degree based on all the second swelling degrees can be implemented by the following steps:

[0119] Convert all the second swelling degrees into a second swelling degree sequence;

[0120] Determine the second difference sequence of the second swelling degree sequence;

[0121] Determine the swelling deviation caused by the cross-linking degree of the carbomer gel on the test result during each second swelling degree test according to the second difference sequence;

[0122] Determine the non-linear deviation caused by the cross-linking degree of the carbomer gel on the swelling degree change of the carbomer gel according to all swelling deviations.

[0123] When specifically implemented, converting all the second swelling degrees into a second swelling degree sequence can be achieved in the following manner, that is: all the second swelling degrees can be sorted from smallest to largest according to the molecular weight of the solvent used in the second swelling degree test, and the sorted sequence is used as the second swelling degree sequence.

[0124] When specifically implemented, determining the second difference sequence of the second swelling degree sequence can be achieved in the following manner, that is: select two adjacent second swelling degrees in the second swelling degree sequence, subtract the earlier second swelling degree from the later second swelling degree, then, use the obtained difference value as the difference value corresponding to the two selected second swelling degrees. Subsequently, select other adjacent two second swelling degrees in the second swelling degree sequence, and continue to obtain the difference values corresponding to each remaining adjacent pair of second swelling degrees. Finally, arrange all the obtained difference values in the order of the second swelling degrees in the second swelling degree sequence, and the arranged sequence is used as the second difference sequence.

[0125] In some embodiments, determining the swelling deviation caused by the cross-linking degree of the carbomer gel in each second swelling degree test according to the second difference sequence can be achieved through the following steps:

[0126] Preset multiple offset coefficients for the molecular weight of the solvent, and determine the molecular weight offset sequence corresponding to each offset coefficient according to each offset coefficient and the second difference sequence;

[0127] Determine the swelling deviation caused by the cross-linking degree of the carbomer gel in each second swelling degree test according to all the molecular weight offset sequences.

[0128] It should be noted that the offset coefficient of the solvent molecular weight in the present application is a parameter used for offset comparison between the solvent molecular weight and the second swelling degree in the second swelling degree test. This offset comparison refers to comparing the second swelling degrees corresponding to different molecular weights, and this offset coefficient can be preset according to actual needs. For example, in the present application, this offset coefficient can be preset to 1, 2, 3, 4, 5 respectively.

[0129] When specifically implemented, determining the molecular weight offset sequence corresponding to each offset coefficient according to each offset coefficient and the second difference sequence can be achieved in the following manner, that is: for each offset coefficient, add m zeros before the second difference value in the second difference sequence, and the obtained sequence is used as the molecular weight offset sequence corresponding to the offset coefficient, where m is the offset coefficient of the solvent molecular weight.

[0130] It should be noted that in this application, the molecular weight offset sequence refers to the sequence after the corresponding relationship between the difference value and the molecular weight of the solvent is offset. For example, for the molecular weight offset sequence with an offset coefficient of x, the y-th difference value in the second difference sequence corresponds to the (y + x)-th value in this molecular weight offset sequence, that is, each difference value is offset by x.

[0131] In specific implementation, to determine the swelling deviation caused by the crosslinking degree of the carbomer gel in each second swelling degree test according to all the molecular weight offset sequences, the following method can be adopted, that is: First, select a molecular weight offset sequence as the selected molecular weight offset sequence. Subsequently, add j zeros after the last difference value in the second difference sequence to make the length of the added sequence the same as that of the selected molecular weight offset sequence. Then, input the added sequence and the selected molecular weight offset sequence into the Yule-Walker equation in the prior art, and use the output result as the swelling deviation caused by the crosslinking degree of the carbomer gel in the first second swelling degree test on the test result. Finally, select the remaining molecular weight offset sequences as the selected molecular weight offset sequences, and repeat the above steps to obtain the swelling deviation caused by the crosslinking degree of the carbomer gel in each second swelling degree test on the test result.

[0132] It should be noted that in this application, the swelling deviation is a parameter representing the degree of loss of the crosslinking degree of the carbomer gel on the swelling degree of the carbomer gel. The larger this swelling deviation is, the more loss the crosslinking degree of the carbomer gel causes to the swelling degree of the carbomer gel in the second swelling degree test, that is, the greater the deviation between the swelling degree of the test result and the true value. The smaller this swelling deviation is, the less loss the crosslinking degree of the carbomer gel causes to the swelling degree of the carbomer gel in the second swelling degree test, that is, the smaller the deviation between the swelling degree of the test result and the true value.

[0133] In specific implementation, to determine the non-linear deviation caused by the crosslinking degree of the carbomer gel on the change of the swelling degree of the carbomer gel according to all the swelling deviations, the following method can be adopted, that is: First, arrange all the swelling deviations in ascending order according to the molecular weight of the solvent in the second swelling degree test. Then, compare each swelling deviation with a preset deviation threshold in turn in the arranged sequence. If the t-th swelling deviation is less than the deviation threshold for the first time, then use t as the non-linear deviation caused by the crosslinking degree of the carbomer gel on the change of the swelling degree of the carbomer gel.

[0134] It should be noted that the deviation threshold is usually preset as a small positive number. For example, this deviation threshold can be preset as 0.05. Those skilled in the art know that the deviation threshold can be preset as other values according to actual needs, and all fall within the protection scope of the present invention, and will not be elaborated here.

[0135] It should be noted that in this application, the non - linear deviation is a parameter indicating the degree to which the swelling degree of carbomer gel deviates from the linear relationship with the change of solution ionic strength. The larger the non - linear deviation, the more the relationship between the swelling degree of carbomer gel and the change of solution ionic strength deviates from linearity; the smaller the non - linear deviation, the less the relationship between the swelling degree of carbomer gel and the change of solution ionic strength deviates from linearity.

[0136] In some embodiments, determining the amount of solvent wrapped by the molecular chains in carbomer gel at unit ionic strength according to the non - linear deviation can be achieved by the following steps:

[0137] Construct a moving average model for the second swelling degree test according to the non - linear deviation;

[0138] Obtain the ionic strength of each solvent in the second swelling test;

[0139] Fit all the second swelling degrees and the ionic strengths of the solvents corresponding to each second swelling degree according to the moving average model, so as to obtain the amount of solvent wrapped by the molecular chains in carbomer gel at unit ionic strength.

[0140] Specifically, constructing a moving average model for the second swelling degree test according to the non - linear deviation can be achieved in the following way: that is, the autoregressive moving average model in the prior art can be used as the moving average model for the second swelling degree test. Set the autoregressive order in the autoregressive moving average model to the same value as the change order in this application, and set the moving average order in the autoregressive moving average model to the same value as the non - linear deviation in this application. Subsequently, set the difference order in the autoregressive moving average model to one. Finally, use this autoregressive moving average model as the moving average model for the second swelling degree test.

[0141] Specifically, fitting all the second swelling degrees and the ionic strengths of the solvents corresponding to each second swelling degree according to the moving average model, so as to obtain the amount of solvent wrapped by the molecular chains in carbomer gel at unit ionic strength can be achieved in the following way: that is, input all the second swelling degrees and the concentrations of the solvents corresponding to each second swelling degree into the moving average model for fitting. Factorize the obtained moving average function and convert it into a function with only one coefficient. Use this coefficient as the amount of solvent wrapped by the molecular chains in carbomer gel at unit ionic strength.

[0142] It should be noted that in the present application, the encapsulation amount is a parameter indicating how much the aqueous solution is encapsulated by the molecular chains in the carbomer gel. This encapsulation amount refers to the amount of aqueous solution encapsulated when the molecules in the carbomer gel form a three-dimensional network chain structure (i.e., molecular chains) from a random state to an extended state under a unit ionic strength. The larger the encapsulation amount, the more the aqueous solution is encapsulated by the three-dimensional network chain structure formed by the molecules in the carbomer gel from a random state to an extended state under a unit ionic strength; the smaller the encapsulation amount, the less the aqueous solution is encapsulated by the three-dimensional network chain structure formed by the molecules in the carbomer gel from a random state to an extended state under a unit ionic strength.

[0143] In addition, it should be noted that under a unit ionic strength, due to the electroviscous effect, the carbomer gel combines with carboxylate ions in the aqueous solution to form a counterion atmosphere, causing mutual repulsion between the carboxylate ions on the molecular chains. When the molecules form a three-dimensional network chain structure from a random state to an extended state, they will encapsulate the aqueous solution. When the electrolyte ionic strength increases, the repulsive force between the carboxylate ions is reduced, the degree of molecular expansion decreases, and the molecular chains in the carbomer gel will show a more curled state, which will lead to a decrease in the amount of encapsulated solution, and macroscopically, it is manifested as a decrease in the swelling degree of the carbomer gel.

[0144] In step 106, based on the contribution degree and the encapsulation amount, determine the swelling responsiveness of the carbomer gel swelling degree to the change in ionic strength in the solvent, and generate a swelling degree test result based on the swelling responsiveness.

[0145] In some embodiments, refer to Figure 4 , this figure is an exemplary flowchart for determining the swelling responsiveness according to some embodiments of the present application. In the present application, the swelling responsiveness of the carbomer gel swelling degree to the change in ionic strength in the solvent can be determined based on the contribution degree and the encapsulation amount by the following steps:

[0146] In step 1061, determine the intercept of the Flory formula according to the contribution degree;

[0147] In step 1062, determine the slope of the Flory formula according to the encapsulation amount;

[0148] In step 1063, determine the power of the dependent variable in the Flory formula according to the non-linear deviation;

[0149] In step 1064, use the Flory formula constructed by the intercept, the slope, and the power of the dependent variable as the swelling responsiveness of the carbomer gel swelling degree to the change in ionic strength in the solvent.

[0150] In specific implementation, determining the intercept of the Flory formula according to the contribution degree means using the contribution degree as the intercept of the Flory formula; in addition, determining the slope of the Flory formula according to the wrapping amount means using the wrapping amount as the slope of the Flory formula; further, determining the power of the dependent variable in the Flory formula according to the non-linear deviation means using the non-linear deviation as the power of the dependent variable in the Flory formula.

[0151] It should be noted that in this application, the swelling responsiveness refers to the characteristic that the swelling degree of the carbomer gel changes with the ionic strength in the solvent, which describes how the swelling degree of the carbomer gel changes correspondingly when the ionic strength in the solvent changes.

[0152] In some embodiments, generating a swelling degree test result based on the swelling responsiveness means plotting a swelling degree curve graph of the carbomer gel according to the swelling responsiveness and using the swelling degree curve graph as the swelling degree test result.

[0153] In specific implementation, plotting the swelling degree curve graph of the carbomer gel according to the swelling responsiveness can be achieved in the following way, that is: the formula corresponding to the swelling responsiveness can be input into Mathematica software, and the swelling degree curve graph is generated through Mathematica software and used as the swelling degree test result of the carbomer gel. In other embodiments, the swelling degree curve graph of the carbomer gel can also be plotted through other existing technologies, which is not limited here.

[0154] It should be noted that in this application, all the first swelling degrees, the concentrations of the solvents corresponding to each first swelling degree, all the second swelling degrees, and the molecular weights of the electrolytes in the solvents corresponding to each second swelling degree can be recorded as test data in the test report; at the same time, the swelling degree curve graph is recorded as the test result in the compatibility test report of the carbomer gel, which will not be elaborated here.

[0155] In some embodiments, referring to Figure 5 , this figure is the swelling degree curve graph of the carbomer gel shown in some embodiments of this application. Through this curve graph, the change situation of the swelling degree of the carbomer gel under different ionic strength environments can be known.

[0156] In addition, on the other hand of this application, in some embodiments, this application provides a device for testing the swelling degree of a carbomer gel. In specific implementation, first prepare a sample of the carbomer gel and prepare the test equipment required for the test. The test equipment includes a centrifuge and an intelligent sensor, and the test equipment is controlled by the device for testing the swelling degree of the carbomer gel to conduct the test. Referring to Figure 6, This figure is a schematic structural diagram of a carbomer gel swelling degree testing device shown according to some embodiments of the present application. The carbomer gel swelling degree testing device 600 includes: a first testing module 601, a first processing module 602, a second testing module 603, a second processing module 604, and an execution module 605, which are described as follows:

[0157] The first testing module 601. In the present application, the first testing module 601 is mainly used to instruct the centrifuge to perform a first swelling degree test on a sample of carbomer coagulant under the same electrolyte and different concentration solvents, and detect the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor;

[0158] The first processing module 602. In the present application, the first processing module 602 is mainly used to determine the order of change of free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determine the contribution degree of the hydrophilicity of the carbomer gel to the change in swelling degree according to the order of change;

[0159] The second testing module 603. In the present application, the second testing module 603 is mainly used to instruct the centrifuge to perform a second swelling degree test on a sample of carbomer coagulant under different electrolytes and different concentration solvents, and detect the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor;

[0160] The second processing module 604. In the present application, the second processing module 604 is mainly used to determine the non-linear deviation caused by the crosslinking degree of the carbomer gel to the change in the swelling degree of the carbomer gel based on all the second swelling degrees, and then determine the amount of solvent wrapped by the molecular chains in the carbomer gel at a unit ionic strength according to the non-linear deviation;

[0161] The execution module 605. In the present application, the execution module 605 is mainly used to determine the swelling responsiveness of the carbomer gel swelling degree to the change in ionic strength in the solvent according to the contribution degree and the amount of wrapping, and generate a swelling degree test result based on the swelling responsiveness.

[0162] In summary, in the method for testing the swelling degree of carbomer gel disclosed in the embodiments of the present application, first, a sample of carbomer gel is prepared, and the test equipment required for the test is prepared. The test equipment includes a centrifuge and an intelligent sensor. The first swelling degree test of the carbomer gel sample is carried out under the same electrolyte and different concentration solvents by the centrifuge, and the first swelling degree corresponding to each selected solvent during the first swelling degree test is detected based on the intelligent sensor. The change order of the free energy related to the hydrophilicity of the carbomer gel is determined based on all the first swelling degrees, and then the contribution degree of the hydrophilicity of the carbomer gel to the change of the swelling degree is determined according to the change order. The second swelling degree test of the carbomer gel sample is carried out under different electrolytes and different concentration solvents by the centrifuge, and the second swelling degree corresponding to each selected solvent during the second swelling degree test is detected based on the intelligent sensor. The non-linear deviation caused by the cross-linking degree of the carbomer gel to the change of the swelling degree of the carbomer gel is determined based on all the second swelling degrees, and then the amount of solvent wrapped by the molecular chains in the carbomer gel under the unit ionic strength is determined according to the non-linear deviation. The swelling responsiveness of the carbomer gel to the change of the ionic strength in the solvent is determined according to the contribution degree and the amount of wrapping, and the swelling degree test result is generated based on the swelling responsiveness.

[0163] It can be seen that the present application conducts the swelling degree test of the carbomer gel under the same electrolyte and different concentration solvents, and then evaluates the contribution degree of the hydrophilicity of the carbomer gel to the change of the swelling degree through the change characteristics of the test results (i.e., the change order of the free energy). Subsequently, the swelling degree test of the carbomer gel is carried out with different electrolytes and different concentration solvents, and the non-linear deviation caused by the cross-linking degree of the carbomer gel to the change of the swelling degree of the carbomer gel under solvents with different molecular weights is obtained. Then, the amount of wrapping of the molecular chains in the carbomer gel to the aqueous solution under the unit ionic strength is determined through the non-linear deviation. Finally, the non-linear characteristics of the swelling degree of the carbomer gel with the change of the ionic strength are determined through the contribution degree and the amount of wrapping, and the swelling responsiveness of the carbomer gel to the change of the ionic strength in the solvent is fitted through the non-linear characteristics. The swelling degree test result is generated based on the swelling responsiveness. In summary, the present application can establish the transfer relationship between the swelling degree of the carbomer gel and the ionic strength in the solvent, and thus improve the versatility of the swelling degree test result of the carbomer gel.

[0164] Although the preferred embodiments of the present application have been described, those skilled in the art can make additional changes and modifications once they know the basic creative concept. Therefore, the appended claims are intended to be construed to include the preferred embodiments and all changes and modifications falling within the scope of the present application.

[0165] Obviously, those skilled in the art can make various changes and modifications to this application without departing from the spirit and scope of this application. Thus, if these modifications and variations of this application fall within the scope of the claims of this application and their equivalent technologies, this application is also intended to cover these modifications and variations.

Claims

1. A method for testing the swelling degree of carbomer gel, characterized in that, The method includes the following steps: Prepare a sample of carbomer gel and prepare the test equipment required for testing. The test equipment includes a centrifuge and an intelligent sensor; Perform a first swelling degree test on the sample of carbomer gel under the same electrolyte and different concentration solvents through the centrifuge, and detect the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor; Determine the order of change of the free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees, and then determine the contribution of the hydrophilicity of the carbomer gel to the change in the swelling degree according to the order of change; Perform a second swelling degree test on the sample of carbomer gel under different electrolytes and different concentration solvents through the centrifuge, and detect the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor; Determine the non-linear deviation caused by the cross-linking degree of the carbomer gel to the change in the swelling degree of the carbomer gel based on all the second swelling degrees, and then determine the amount of solvent wrapped by the molecular chains in the carbomer gel under unit ionic strength according to the non-linear deviation; Determine the swelling responsiveness of the carbomer gel swelling degree to the change in ionic strength in the solvent according to the contribution degree and the amount of wrapping, and generate a swelling degree test result based on the swelling responsiveness; Among them, determining the order of change of the free energy related to the hydrophilicity of the carbomer gel based on all the first swelling degrees specifically includes: Convert all the first swelling degrees into a first swelling degree sequence; Determine the first difference sequence of the first swelling degree sequence; Determine the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence; Determine the order of change of the free energy related to the hydrophilicity of the carbomer gel according to all the change amounts of the free energy; Among them, determining the contribution of the hydrophilicity of the carbomer gel to the change in the swelling degree according to the order of change specifically includes: Construct a fitting model for the first swelling degree test according to the order of change; Fit all the first swelling degrees and the concentration of the solvent corresponding to each first swelling degree according to the fitting model, and then obtain the contribution of the hydrophilicity of the carbomer gel to the change in the swelling degree; Among them, determining the non-linear deviation caused by the cross-linking degree of the carbomer gel to the change in the swelling degree of the carbomer gel based on all the second swelling degrees specifically includes: Convert all the second swelling degrees into a second swelling degree sequence; Determine the second difference sequence of the second swelling degree sequence; Determine the swelling deviation caused by the cross-linking degree of the carbomer gel to the test result in each second swelling degree test according to the second difference sequence; Determine the non-linear deviation caused by the cross-linking degree of the carbomer gel to the change in the swelling degree of the carbomer gel according to all the swelling deviations; Among them, determining the amount of solvent wrapped by the molecular chains in the carbomer gel under unit ionic strength according to the non-linear deviation specifically includes: Construct a moving average model for the second swelling degree test according to the non-linear deviation; Obtain the ionic strength of each solvent in the second swelling test; Fitting all the second swelling degrees and the ionic strength of the solvent corresponding to each second swelling degree according to the moving average model, so as to obtain the amount of molecular chains in the carbomer gel wrapping the solvent under unit ionic strength; Among them, determining the swelling responsiveness of the carbomer gel swelling degree to the change of ionic strength in the solvent according to the contribution degree and the wrapping amount specifically includes: Determining the intercept of the Flory formula according to the contribution degree; Determining the slope of the Flory formula according to the wrapping amount; Determining the power of the dependent variable in the Flory formula according to the non-linear deviation; Taking the Flory formula constructed by the intercept, the slope and the power of the dependent variable as the swelling responsiveness of the carbomer gel swelling degree to the change of ionic strength in the solvent.

2. The method according to claim 1, wherein Preparing a sample of the carbomer gel means taking any weight of the carbomer gel and drying it in an oven for a preset period, and using the dried carbomer gel as the sample of the carbomer gel.

3. The method according to claim 1, characterized in that, Testing the first swelling degree of the sample of the carbomer gel under the same electrolyte and solvents with different concentrations by the centrifuge, and detecting the first swelling degree corresponding to each selected solvent during the first swelling degree test based on the intelligent sensor specifically includes: Selecting an electrolyte, and preparing solvents with multiple different electrolyte concentrations according to the electrolyte; Selecting a solvent as the first selected solvent; Weighing the sample of the carbomer gel by the intelligent sensor to obtain the first sample mass; Adding the sample of the carbomer gel and the first selected solvent into a dry centrifuge tube and stirring; Putting the stirred centrifuge tube into a centrifuge for centrifugation; Tilting and standing the centrifuged centrifuge tube, then removing the upper-layer solvent in the centrifuge tube, and weighing the centrifuge tube after removing the upper-layer solvent by the intelligent sensor to obtain the first test mass; Determining the first swelling degree of the first selected solvent corresponding to the first swelling degree test according to the first sample mass and the first test mass; Selecting the remaining other solvents, and continuing to obtain the first swelling degrees of the remaining solvents corresponding to the first swelling degree test.

4. The method according to claim 1, wherein Determining the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to the first difference sequence specifically includes: Presetting offset coefficients of multiple solvent solubilities, and determining the solubility offset sequence corresponding to each offset coefficient according to each offset coefficient and the first difference sequence; Determining the change amount of the free energy related to the hydrophilicity of the carbomer gel in each first swelling degree test according to all the solubility offset sequences.

5. The method according to claim 1, wherein Testing the second swelling degree of the sample of the carbomer gel under different electrolytes and solvents with different concentrations by the centrifuge, and detecting the second swelling degree corresponding to each selected solvent during the second swelling degree test based on the intelligent sensor specifically includes: Selecting multiple electrolytes, and preparing solvents with multiple different electrolytes and different concentrations according to all the electrolytes; Selecting a solvent as the second selected solvent; Weighing the sample of the carbomer gel by the intelligent sensor to obtain the second sample mass; Adding the sample of the carbomer gel and the second selected solvent into a dry centrifuge tube and stirring; Putting the stirred centrifuge tube into a centrifuge for centrifugation; Tilt and let the centrifuge tube stand still after centrifugation, then remove the upper-layer solvent in the centrifuge tube, and weigh the centrifuge tube after removing the upper-layer solvent through the intelligent sensor to obtain the second test mass; Determine the second swelling degree corresponding to the second swelling degree test of the second selected solvent according to the second sample mass and the second test mass; Select the remaining other solvents, and continue to obtain the second swelling degrees corresponding to the second swelling degree tests of the remaining solvents.

6. The method according to claim 1, characterized in that, The centrifuge is a floor-standing low-speed electric centrifuge.

7. The method according to claim 1, characterized in that, The intelligent sensor is an integrated sensor for weighing and temperature measurement.

8. The method according to claim 1, wherein Generating the swelling degree test result based on the swelling responsiveness means drawing a swelling degree curve graph of the carbomer gel according to the swelling responsiveness, and taking the swelling degree curve graph as the swelling degree test result.

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