A uterus-warming Chinese medicine composition, a uterus-warming acupoint patch containing the same, and a preparation method

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and relates to a kind of uterus warming Chinese medicine composition, uterus warming acupoint patch containing it and preparation method. The composition includes by weight: 100-200 parts of wormwood, 80-120 parts of evodia rutaecarpa, 10-50 parts of prickly ash, 50-80 parts of dried ginger, 20-80 parts of cassia twig, 40-60 parts of chuanxiong and 50-100 parts of stir-fried white mustard seeds. The uterus warming Chinese medicine composition of the present invention has simple prescription, reasonable dosage and remarkable drug effect, and is used for uterus warming acupoint patch, and has remarkable therapeutic effect for the symptoms such as dysmenorrhea and irregular menstruation caused by cold palace etc. in women's menstrual period.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a uterus-warming traditional Chinese medicine composition, a uterus-warming acupoint patch containing the composition, and a preparation method. Background Art

[0002] Treatment of uterine cold is a treatment for diseases caused by coldness in the uterus of female patients in traditional Chinese medicine, such as dysmenorrhea, late menstruation, infertility, etc. Traditional Chinese medicine believes that uterine cold is related to kidney deficiency, spleen deficiency, blood deficiency, liver depression, phlegm dampness, damp heat, blood stasis, etc. Western medicine believes that such symptoms are mostly related to age factors, nutritional factors, mental factors, endocrine factors (hypothalamus, thyroid, adrenal glands, pancreas), developmental factors, inflammation, tumors, etc.

[0003] Chinese invention patent application CN104107318A discloses a Chinese medicine composition for treating menstrual disorders of blood stasis and yin stagnation type, which is composed of the following components in proportion by weight: 20-40 parts of Leonurus japonicus, 10-15 parts of Angelica sinensis, 6-12 parts of Chuanxiong, 6-12 parts of White Peony Root, 6-12 parts of Aucklandia lappa, 6-12 parts of Vinegar-processed Corydalis yanhusuo, 10-15 parts of Rehmannia glutinosa, 6-12 parts of Red Peony Root, 6-12 parts of Carthamus tinctorius, and 12 parts of Radix Codonopsis pilosulae. The Chinese medicine composition comprises 6-12 parts of Chinese medicine, 12-18 parts of Atractylodes macrocephala, 12-18 parts of Salvia miltiorrhiza, 10-15 parts of Cyperus rotundus, 10-15 parts of Evodia rutaecarpa, 10-15 parts of Herba Lycopodiellae, 12-18 parts of Caulis Spatholobi, 10-15 parts of Cuscuta australis, 10-15 parts of Artemisia argyi carbon, 12-18 parts of Poria, 6-12 parts of Fennel, 6-12 parts of Paeonia suffruticosa, 6-12 parts of Dipsacus asper, 6-12 parts of Scutellaria baicalensis, 10-15 parts of Radix Ophiopogonis, and 3-9 parts of Licorice. The Chinese medicine composition is used in combination by all the medicines to promote blood circulation and replenish blood, and to relieve pain by promoting qi circulation, and has a good therapeutic effect on menstrual disorders of blood stasis type. However, it is necessary to decoct the medicine before taking the Chinese medicine, which is time-consuming and laborious, and the taste is heavy, and the patient compliance is poor.

[0004] Chinese invention patent application CN117298295A discloses a dysmenorrhea patch and a preparation method thereof, wherein the effective ingredients of the dysmenorrhea patch include a volatile oil cyclodextrin inclusion compound and a drug concentrate, wherein the volatile oil cyclodextrin inclusion compound is prepared by embedding volatile oil in the cavity of β-cyclodextrin, and the raw materials of the drug concentrate include Chinese medicine residues remaining after extracting volatile oil from cinnamon, roasted ginger, wormwood, and Chuanxiong, as well as Wulingzhi, Typhae Pollen, Angelica, Red Peony Root, Vinegar Cyperus, Aucklandia, Chuanwu, Trillium, Vinegar Corydalis, Toosendan Fructus and Fennel. The dysmenorrhea patch can relieve the symptoms of primary dysmenorrhea, has a good curative effect, and can also be used in combination with a self-heating pack to make the effect of the plaster more obvious on the basis of hot compress. However, the dysmenorrhea patch and the aforementioned Chinese medicine composition contain more active drug ingredients, and the full play of their drug effects will be subject to certain restrictions.

[0005] Based on this, it is necessary to conduct in-depth research on the mechanism of action of ingredients with corresponding functions and their compatibility with each other, and streamline the formulation to maximize the efficacy of active ingredients and save costs. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention provides a uterus warming Chinese medicine composition, a uterus warming acupoint patch containing the same and a preparation method. The uterus warming Chinese medicine composition has a simple formula, a reasonable dosage and significant efficacy. It is used in the uterus warming acupoint patch, and has a significant therapeutic effect on symptoms such as dysmenorrhea and irregular menstruation caused by uterine coldness during women's menstrual period.

[0007] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0008] The invention provides a uterus warming Chinese medicine composition, which comprises, by weight, 100-200 parts of wormwood leaves, 80-120 parts of evodia rutaecarpa, 10-50 parts of prickly ash, 50-80 parts of dried ginger, 20-80 parts of cassia twigs, 40-60 parts of chuanxiong and 50-100 parts of stir-fried white mustard seeds.

[0009] Preferably, the composition comprises, by weight: 120-180 parts of wormwood leaves, 90-110 parts of evodia rutaecarpa, 20-40 parts of prickly ash, 60-80 parts of dried ginger, 20-60 parts of cassia twig, 45-55 parts of ligusticum chuanxiong and 70-100 parts of stir-fried white mustard seeds.

[0010] More preferably, the composition comprises, by weight: 120-150 parts of wormwood leaves, 100-110 parts of evodia rutaecarpa, 30-40 parts of prickly ash, 60-70 parts of dried ginger, 40-60 parts of cassia twig, 45-50 parts of ligusticum chuanxiong and 70-80 parts of stir-fried white mustard seeds.

[0011] Further preferably, the composition comprises, by weight: the composition comprises, by weight: 140 parts of mugwort leaves, 100 parts of evodia rutaecarpa, 35 parts of zanthoxylum bungeanum, 65 parts of dried ginger, 50 parts of cassia twig, 47 parts of ligusticum chuanxiong and 75 parts of stir-fried white mustard seeds.

[0012] Still more preferably, the weight ratio of wormwood leaf and Evodia rutaecarpa is (7-10):(4-5).

[0013] Still further preferably, the peppercorns are 15-25% of the total weight of the fried white mustard seeds and dried ginger.

[0014] The Chinese medicinal ingredients used in the present invention have the following effects:

[0015] Tao Hongjing's "Famous Doctors' Records" made a comprehensive discussion on the medicinal properties of mugwort: "Mugwort is bitter, slightly warm, and non-toxic. It cures all kinds of inflammatory diseases, can be boiled, stops diarrhea, hematemesis, lower body sores, women's bleeding, benefits yin, builds muscles, avoids wind and cold, and makes people have children. It is also called ice platform and medical grass, and grows in the fields." The applications of "stopping diarrhea, women's bleeding, and epistaxis" recorded in it have been followed by later generations. In modern clinical applications, mugwort is widely used to treat gynecological diseases such as metrorrhagia, dysmenorrhea, ectopic pregnancy, fetal movement disorder, miscarriage, infertility, and women's leucorrhea.

[0016] Evodia rutaecarpa has the effects of warming the middle, relieving pain, and treating abdominal pain during menstruation;

[0017] Zanthoxylum bungeanum is used to treat abdominal pain caused by cold, vomiting and diarrhea caused by cold and dampness. When taken with ginger and jujube, it has a stronger effect in removing cold and dampness and can also relieve abdominal pain. It is also used to relieve the symptoms of cold uterus (excessive and thin leucorrhea, long-term dysmenorrhea) in women.

[0018] Dried ginger has the effect of warming the middle and dispelling cold, and can be used to treat dysmenorrhea caused by stagnation of cold pathogens;

[0019] Cinnamon twig can warm and dredge the meridians, and can be used to treat amenorrhea and dysmenorrhea caused by cold stagnation of qi and blood.

[0020] According to the Ben Jing, Tangye Bencao and Pharmacopoeia, Chuanxiong can be used to promote blood circulation and qi, dispel wind and relieve pain, and has a certain effect on symptoms such as headache and irregular menstruation.

[0021] Fried white mustard seeds are made by frying white mustard seeds, which have the effect of warming the middle and dispersing cold.

[0022] The components in the uterus warming composition of the present invention work synergistically, such as Chuanxiong and cinnamon twig are used to promote blood circulation and qi movement; Evodia rutaecarpa, dried ginger and white mustard seeds warm the middle and dispel cold, and combined with Zanthoxylum bungeanum, the cold-dispelling effect is better; Artemisia argyi, Evodia rutaecarpa and dried ginger can relieve menstrual abdominal pain, and as a whole, it has a good therapeutic effect on female dysmenorrhea and menstrual disorders.

[0023] The present invention also provides a uterus warming acupoint patch, comprising any one of the above-mentioned uterus warming traditional Chinese medicine compositions.

[0024] Furthermore, the uterus warming acupoint patch also includes pharmaceutically acceptable excipients; specifically one or more selected from vaseline, lanolin, zinc oxide, glycerin, laurocapram and rosin and their derivatives.

[0025] The present invention also provides a method for preparing any of the above-mentioned uterus warming acupoint patches, comprising the following steps:

[0026] (1) Mix wormwood leaf, evodia rutaecarpa, prickly ash, dried ginger, cassia twig, ligusticum chuanxiong and fried white mustard seeds, grind and sieve to obtain raw material powder;

[0027] (2) adding the raw drug powder into ginger juice and stirring evenly to obtain the raw drug liquid;

[0028] (3) Add auxiliary materials to the raw material liquid and stir evenly to obtain the product.

[0029] Furthermore, the mass volume ratio of the raw medicinal powder to the ginger juice is 1:(1-5).

[0030] The preparation method of ginger juice is as follows: wash fresh ginger with clean water, cut it into pieces, put it in a stone mortar, add 5-10 times (w / v) clean water, and squeeze it to get the juice. Add clean water (2:1) to the ginger residue and pound it, and then squeeze it to get the juice; repeat 2-3 times, filter out the ginger residue, and the juice is obtained.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] The components in the uterus warming composition of the present invention cooperate with each other, such as wormwood and evodia rutaecarpa cooperate to relieve dysmenorrhea; dried ginger and white mustard seeds warm the middle and dispel cold, and with pepper, the effect of expelling cold is better; Chuanxiong and cassia twig are used to promote blood circulation and qi. With wormwood and evodia rutaecarpa as the main medicine, stir-fried white mustard seeds, dried ginger and pepper as the assistant medicine, relieving dysmenorrhea and warming the middle and dispersing qi are the main medicines; Chuanxiong and cassia twig are used to promote blood circulation and qi; the Chinese medicine composition is used for uterus warming acupoint patch, which has a good therapeutic effect on dysmenorrhea and menstrual disorders caused by uterine cold in women. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described in combination with the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] It is worth noting that the raw materials used in the present invention are all common commercially available products, and their sources are not specifically limited.

[0035] Example 1

[0036] A uterus-warming Chinese medicine composition is composed of the following raw materials in weight ratio: 140 parts of wormwood leaves, 100 parts of evodia rutaecarpa, 35 parts of prickly ash, 65 parts of dried ginger, 50 parts of cassia twigs, 47 parts of chuanxiong, and 75 parts of fried white mustard seeds; the raw materials are directly mixed according to weight, ground and passed through a 200-mesh sieve to obtain the composition.

[0037] Example 2

[0038] A uterus-warming Chinese medicine composition is composed of the following raw materials in weight ratio: 130 parts of wormwood leaves, 110 parts of evodia rutaecarpa, 32 parts of prickly ash, 63 parts of dried ginger, 55 parts of cassia twigs, 42 parts of chuanxiong, and 80 parts of fried white mustard seeds; the raw materials are directly mixed according to weight, ground and passed through a 200-mesh sieve to obtain the composition.

[0039] Example 3

[0040] A uterine warming Chinese medicine composition is composed of the following raw materials in weight ratio: 150 parts of mugwort leaves, 90 parts of evodia rutaecarpa, 25 parts of prickly ash, 50 parts of dried ginger, 37 parts of cassia twigs, 60 parts of chuanxiong, and 100 parts of fried white mustard seeds; the raw materials are directly mixed according to weight parts, ground and passed through a 200-mesh sieve to obtain the composition.

[0041] Example 4

[0042] A uterus-warming Chinese medicine composition is composed of the following raw materials in weight ratio: 130 parts of mugwort leaves, 110 parts of evodia rutaecarpa, 35 parts of prickly ash, 65 parts of dried ginger, 50 parts of cassia twigs, 47 parts of chuanxiong, and 75 parts of fried white mustard seeds; the raw materials are directly mixed according to weight, ground and passed through a 200-mesh sieve to obtain the composition.

[0043] Example 5

[0044] A uterus-warming Chinese medicine composition is composed of the following raw materials in weight ratio: 140 parts of wormwood leaves, 100 parts of evodia rutaecarpa, 40 parts of prickly ash, 60 parts of dried ginger, 50 parts of cassia twigs, 47 parts of chuanxiong, and 75 parts of fried white mustard seeds; the raw materials are directly mixed according to weight, ground and passed through a 200-mesh sieve to obtain the composition.

[0045] Comparative Example 1

[0046] Compared with Example 1, the only difference is that Evodia rutaecarpa is not included and the amount of Artemisia argyi is 240 parts.

[0047] Comparative Example 2

[0048] Compared with Example 1, the only difference is that it does not contain Artemisia argyi and the amount of Evodia rutaecarpa is 240 parts.

[0049] Comparative Example 3

[0050] Compared with Example 1, the difference is only that the wormwood leaves are 100 parts and the Evodia rutaecarpa is 140 parts.

[0051] Comparative Example 4

[0052] Compared with Example 1, the only difference is that the wormwood leaves are 180 parts and the Evodia rutaecarpa is 60 parts.

[0053] Comparative Example 5

[0054] Compared with Example 1, the only difference is that no Zanthoxylum bungeanum is included, and the amount of dried ginger is 81.25 parts and the amount of fried white mustard seeds is 93.75 parts.

[0055] Comparative Example 6

[0056] Compared with Example 1, the only difference is that an equal amount of Salvia miltiorrhiza is used to replace Rhizoma Chuanxiong.

[0057] Comparative Example 7

[0058] Compared with Example 1, the only difference is that an equal amount of Panax notoginseng is used to replace Rhizoma Chuanxiong.

[0059] Test Example 1: Therapeutic Effects on Dysmenorrhea Model Rats

[0060] 150 SD female rats (weight (200±20) g) were selected and randomly divided into 15 groups, 10 rats in each group, namely blank control group, model group, positive control group, experimental group 1-5, and comparative experimental group 1-7. Except for the blank control group, the other groups were subcutaneously injected with diethylstilbestrol for 10 days, once a day, 0.8 mg / rat on the 1st and 10th days, and 0.4 mg / rat on the 2nd to 9th days. Among them, each group was gavaged starting from the 5th day after the subcutaneous injection of diethylstilbestrol. The blank control group and the model group were gavaged with the same amount of distilled water; the positive control group was gavaged with 0.6 g·kg -1 ·d -1 Tianqi Tongjing Capsule, experimental groups 1-5 and control groups 1-7 were gavaged with 0.6 g kg -1 ·d -1 The compositions of Examples 1-5 and Comparative Examples 1-7.

[0061] The drug was administered once a day for 7 consecutive days. One hour after the last administration, oxytocin was injected intraperitoneally at a rate of 2 μL / rat. The pain response of rats in each group was observed within 30 minutes. The number of writhing animals in each group and the average number of writhing were recorded, and the inhibition rate of writhing reaction was calculated. The writhing reaction was an indicator of strong uterine contraction (dysmenorrhea) when the rat's abdomen contracted and concave, the trunk and hind limbs extended, and the arms and one side rotated inward. Among them: the inhibition rate of writhing reaction (%) = (the number of writhing in the model group - the number of writhing in the drug administration group) / the number of writhing in the model group.

[0062] One hour after the rats were injected with oxytocin, they were anesthetized by intraperitoneal injection of chloral hydrate, the abdominal cavity was opened, 2 mL of blood was collected from the abdominal aorta and placed in a test tube, the plasma was separated, and after the blood sample was collected, 50 mg of the uterus in the same position on the same side was taken out, and it was weighed with a precision tissue balance, washed with ice NS (normal saline) containing EDTA-Na2, and then cut into pieces, put into a homogenizer, and 0.5 mL of ice NS was added, and the homogenate was ground to make a uterine homogenate. The mixture was allowed to stand and centrifuged at 2500 r / min and 4°C for 10 min. The supernatant was taken and the content of β-EP in rat plasma and PGF2 in uterine tissue was detected.

[0063] The results of the writhing test of rats in each group are shown in Table 1; the results of the determination of plasma β-EP and uterine tissue PGF2 levels are shown in Table 2.

[0064] Table 1 Analgesic effect on rat writhing test (n=10, )

[0065] Group Number of twists Inhibition rate (%) Blank control group 0 - Model Group 25.3±3.5 - Positive control group 16.4±3.0* 35.18 Experimental Group 1 14.2±4.6* 43.87 Experimental Group 2 15.6±3.8* 38.34 Experimental Group 3 14.9±4.2* 41.11 Experimental Group 4 17.1±3.4* 32.41 Experimental Group 5 16.8±4.6* 33.60 Comparative experimental group 1 19.4±5.1# 23.32 Comparative experimental group 2 20.3±4.9# 19.76 Comparative experimental group 3 18.8±4.7 25.69 Comparative experimental group 4 19.0±5.0 24.90 Comparative experimental group 5 19.7±4.8# 22.13 Comparative experimental group 6 22.5±5.3# 11.07 Comparative experimental group 7 21.7±6.1# 14.23

[0066] Note: Compared with the model group: * P<0.05; compared with experimental group 1: # P<0.05.

[0067] As shown in Table 1, compared with the model group, the composition of experimental groups 1-5 significantly reduced the number of twisting events in rats with oxytocin-induced dysmenorrhea within 30 minutes, and the inhibition rate of twisting was greater than 30%, with the highest reaching 43.87%. Among them, the inhibition rate of experimental groups 1-3 was higher than that of the positive control group Tianqi Dysmenorrhea Capsules. However, the composition of comparative examples 1-7 was not statistically significant compared with the model group. The number of twisting events in comparative experimental groups 1 and 2 was significantly higher than that in experimental group 1, indicating that Artemisia argyi and Evodia rutaecarpa have a synergistic therapeutic effect on oxytocin-induced dysmenorrhea in the composition; the number of twisting events in comparative experimental groups 3 and 4 was higher than that in experimental group 1, but there was no statistical difference; the number of twisting events in comparative experimental groups 5, 6, and 7 was also significantly higher than that in experimental group 1, indicating that Zanthoxylum bungeanum and Chuanxiong also play a key role in the composition.

[0068] Table 2 Effects on plasma β-EP and uterine tissue PGF2 in rats

[0069] Group β-EP(pg / mL) <![CDATA[PGF2(pg / mL)]]> Blank control group 185.34±23.17 117.32±19.65 Model Group 121.78±15.89 199.38±40.07 Positive control group <![CDATA[175.44±30.12 ** ]]> <![CDATA[108.25±16.97 ** ]]> Experimental Group 1 <![CDATA[189.46±34.71 ** ]]> <![CDATA[96.43±18.24 ** ]]> Experimental Group 2 <![CDATA[185.33±41.90 ** ]]> <![CDATA[112.43±20.15 ** ]]> Experimental Group 3 <![CDATA[188.35±35.56 ** ]]> <![CDATA[100.47±17.85 ** ]]> Experimental Group 4 <![CDATA[173.26±34.07 ** ]]> <![CDATA[117.49±23.74 ** ]]> Experimental Group 5 <![CDATA[177.42±40.25 ** ]]> <![CDATA[110.32±19.80 ** ]]> Comparative experimental group 1 <![CDATA[153.13±25.44 *# ]]> <![CDATA[173.86±30.28 ## ]]> Comparative experimental group 2 <![CDATA[158.81±30.61 **# ]]> <![CDATA[160.59±26.44 *## ]]> Comparative experimental group 3 <![CDATA[170.88±32.11 ** ]]> <![CDATA[149.39±25.68 *# ]]> Comparative experimental group 4 <![CDATA[165.42±28.91 ** ]]> <![CDATA[155.57±28.63 *# ]]> Comparative experimental group 5 <![CDATA[143.76±25.50 *# ]]> <![CDATA[165.85±25.14 *## ]]> Comparative experimental group 6 <![CDATA[154.31±38.42 *# ]]> <![CDATA[177.36±28.91 ## ]]> Comparative experimental group 7 <![CDATA[160.48±27.77 ** ]]> <![CDATA[165.27±30.05 *## ]]>

[0070] Note: Compared with the model group: * P<0.05, ** P<0.01; compared with experimental group 1: # P<0.05.

[0071] As shown in Table 2, compared with the model group, the compositions of experimental groups 1-5 significantly increased the content of endogenous analgesic substance β-EP in plasma of rats with oxytocin-induced dysmenorrhea model, and significantly reduced the content of PGF2 in uterine tissue of rats with oxytocin-induced dysmenorrhea model, and the effect of experimental groups 1-3 was better, which was the preferred embodiment of the present invention. The compositions of comparative examples 1-7 can also increase the content of endogenous analgesic substance β-EP in plasma and reduce the content of PGF2 in uterine tissue, but the effect is worse than that of experimental groups 1-5. Among them, the content of β-EP in comparative experimental groups 1 and 2 is significantly different from that in experimental group 1, and the content of PGF2 is significantly different, indicating that wormwood and Evodia rutaecarpa can synergistically enhance the analgesic effect; the content of β-EP in comparative experimental groups 3 and 4 is lower than that in experimental group 1, but there is no significant difference, the content of PGF2 is higher, and there is a significant difference. There were significant differences in the content of β-EP in experimental group 5 compared with experimental group 1, indicating that the dosage of wormwood and Evodia rutaecarpa also played a certain role in the relief of oxytocin-induced dysmenorrhea; compared with experimental group 1, there was a significant difference in the content of β-EP in experimental group 5, and a very significant difference in the content of PGF2, indicating that the combination of Zanthoxylum bungeanum with dried ginger and fried white mustard had a better effect; compared with experimental group 1, there were also certain differences in the content of β-EP in experimental groups 6 and 7, and a very significant difference in the content of PGF2, indicating that the type of blood-activating ingredients in the combination with other ingredients is also crucial to the relief of dysmenorrhea.

[0072] Example 6

[0073] A uterus warming acupuncture point patch, the preparation method is as follows:

[0074] (1) Grind the raw materials of the composition of Example 1 and pass them through a 200-mesh sieve to obtain raw material powder;

[0075] (2) Preparation of ginger juice: Wash fresh ginger with clean water, cut it into pieces, put it into a stone mortar, add 10 times (w / v) clean water, and squeeze it to extract juice. Add clean water (2:1) to the ginger residue and pound it, then squeeze it to extract juice; repeat 2-3 times, filter out the ginger residue, and set aside;

[0076] (3) Add the raw drug powder to ginger juice (the mass volume ratio of the two is 1:1), stir evenly, then add 30 parts of white vaseline, 18 parts of laurocapram, and 45 parts of medical glycerin, stir thoroughly, and apply to the acupuncture point patch to obtain the product.

[0077] Test case 2: Clinical case

[0078] General data: A total of 100 clinical cases were collected from the North Hospital of Yulin Traditional Chinese Medicine Hospital during the period of November 2023 to March 2024, mainly with symptoms such as delayed menstruation, scanty menstruation, dysmenorrhea or amenorrhea, and metrorrhagia.

[0079] Usage: Apply two pieces (or one piece) to the Qihai and Guanyuan points (or Shenjue point) once a day. Take 2-3 jin of coarse salt, add 5g of peppercorns, fry in a pot for 2-3 minutes, and put into a gauze bag. Apply on the acupoint patch. Keep the coarse salt for 30 minutes and the acupoint patch for 2-3 hours.

[0080] Efficacy criteria:

[0081] (1) Recovery: Clinical symptoms and signs completely disappear or almost disappear;

[0082] (2) Markedly effective: most clinical symptoms and signs improved or significantly improved;

[0083] (3) Ineffective: There is no significant improvement in clinical symptoms and signs, the symptoms remain the same, and the effect is not obvious.

[0084] The total effective rate of treatment is the sum of the cure rate and the markedly effective rate.

[0085] Typical cases:

[0086] Patient Zhang, female, 27 years old

[0087] Initial visit: January 23, 2024. Main complaint: menstruation is delayed by about 10 days, and no pregnancy for half a year without contraception. Current medical history: cold pain in the lower abdomen, chills, ultrasound shows that the endometrium is 0.9cm. Past history: previous menstruation was once every 37 days, the amount was heavy, the color was dark red, there were blood clots, the menstrual period was 7 days, dysmenorrhea, and the lower abdomen was cold to the touch. Moxibustion and magic lamp irradiation in the beauty salon were not effective. Came to our department for treatment on January 23, 2024, and menstruation came after 4 days of medication with the warm palace degree patch of Example 6.

[0088] Second visit: January 29, 2024. Main complaint: On the second day of menstruation, the menstrual volume was less than before, the color was normal, there were no blood clots, the lower abdomen was slightly painful, and the cold abdomen was significantly improved. There was no other discomfort. Our department continued to take the medicine for 14 days as before.

[0089] Third visit: February 29, 2024. Main complaint: 3rd day of menstruation, 29 days of cycle, normal menstrual flow, normal color, no blood clots, slight pain in lower abdomen, cold abdomen has disappeared, no other discomfort. Our department continued to give medication for 7 days.

[0090] Follow-up 3 months later showed that the symptoms had disappeared and no recurrence was observed.

[0091] The statistical results of clinical data are shown in Table 3.

[0092] Table 3 Clinical treatment effects of the warm uterus acupoint patch of the present invention

[0093]

[0094] As can be seen from the above table, the uterus warming Chinese medicine composition of the present invention can relieve women's menstrual disorders, scanty menstruation, lower abdominal pain and other problems, and after safety observation, no adverse reactions were found and no side effects.

[0095] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A uterine warming Chinese medicine composition, characterized in that The composition is composed of the following raw materials in parts by weight: 100-200 parts of mugwort leaves, 80-120 parts of evodia rutaecarpa, 10-50 parts of prickly ash, 50-80 parts of dried ginger, 20-80 parts of cassia twigs, 40-60 parts of chuanxiong and 50-100 parts of fried white mustard seeds.

2. The uterus-warming Chinese medicine composition according to claim 1, characterized in that The composition is composed of the following raw materials in parts by weight: 120-180 parts of mugwort leaves, 90-110 parts of evodia rutaecarpa, 20-40 parts of prickly ash, 60-80 parts of dried ginger, 20-60 parts of cassia twigs, 45-55 parts of chuanxiong and 70-100 parts of fried white mustard seeds.

3. The uterus-warming Chinese medicine composition according to claim 2, characterized in that The composition is composed of the following raw materials in parts by weight: 120-150 parts of mugwort leaves, 100-110 parts of evodia rutaecarpa, 30-40 parts of prickly ash, 60-70 parts of dried ginger, 40-60 parts of cassia twigs, 45-50 parts of chuanxiong and 70-80 parts of fried white mustard seeds.

4. The uterus-warming Chinese medicine composition according to claim 3, characterized in that: The composition is composed of the following raw materials in parts by weight: the composition comprises, in parts by weight: 140 parts of mugwort leaves, 100 parts of evodia rutaecarpa, 35 parts of prickly ash, 65 parts of dried ginger, 50 parts of cassia twigs, 47 parts of ligusticum chuanxiong and 75 parts of stir-fried white mustard seeds.

5. The uterus-warming Chinese medicine composition according to claim 1, characterized in that: The weight ratio of the wormwood leaf and the Evodia rutaecarpa is (7-10):(4-5).

6. The uterus-warming Chinese medicine composition according to claim 1, characterized in that: The peppercorns are 15-25% of the total weight of the fried white mustard and dried ginger.

7. A uterus warming acupuncture point patch, characterized in that: A uterine warming Chinese medicine composition comprising any one of claims 1-6.

8. The uterus warming acupuncture point patch according to claim 7, characterized in that: It also includes pharmaceutically acceptable excipients, which are specifically selected from one or more of vaseline, lanolin, zinc oxide, glycerin, laurocapram and rosin.

9. The method for preparing the uterus warming acupoint patch according to claim 7 or 8, characterized in that: The following steps are involved: (1) Mix wormwood leaf, evodia rutaecarpa, prickly ash, dried ginger, cassia twig, ligusticum chuanxiong and fried white mustard seeds, grind and sieve to obtain raw material powder; (2) adding the raw drug powder into ginger juice and stirring evenly to obtain the raw drug liquid; (3) Add auxiliary materials to the raw material liquid and stir evenly to obtain the product.

10. The preparation method according to claim 9, characterized in that: The mass volume ratio of the raw medicinal powder to the ginger juice is 1:(1-5).

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