Method for detecting dynamic adhesion performance of hydrogel patch

Abstract

The invention discloses a method for detecting the dynamic adhesion performance of a hydrogel patch. The method comprises a method for detecting the adhesion performance of the hydrogel patch under the wriggling action and a method for detecting the adhesion performance of the hydrogel patch under the bending, twisting and stretching actions. The bending and rotating actions of a human wrist are simulated through a bionic method, the bending and rotating actions of the hydrogel patch adhered to the human wrist are simulated, and the dynamic adhesion performance of the hydrogel patch under the stretching of the human skin surface is tested; the dynamic adhesion performance of the hydrogel patch on the wet surface of the organ is tested by simulating the action of organ muscle wriggling, simulating the liquid impact on the hydrogel patch when the hydrogel patch is adhered inside the organ and the influence of intestinal wall wriggling on the adhesion effect of the hydrogel patch; the device simulates the contraction and relaxation actions of human and animal skins, simulates the compression and stretching of the hydrogel patch adhered to the human skin, can obtain the effect of the actual working condition through simulation, and can detect the dynamic adhesion performance of the hydrogel patch without clinical tests.

Description

Technical Field

[0001] The invention relates to an adhesion performance detection method, in particular to a method for detecting the dynamic adhesion performance of a hydrogel patch, and belongs to the technical field of hydrogel patch detection. Background Art

[0002] Hydrogel patches refer to patches made of hydrophilic materials such as hydrogels, which can be used for sensing, medication, electronic skin, etc. As an emerging material, hydrogel has a dense network structure and contains a large amount of water. It is a type of extremely hydrophilic three-dimensional network structure gel. Due to its extremely high biocompatibility and soft, porous network structure, hydrogels are often used in the medical field and hydrogel wearable electronics. For the medical field, hydrogel drug delivery is an innovative and superior clinical treatment method. The porous network structure is conducive to the release of drugs. Therefore, it will become a convenient and efficient method to apply hydrogel patches or hydrogel microneedle patches to the affected area of ​​the patient for treatment. Hydrogel patches can also be used for drug application or hole filling in the oral cavity, intestines and other affected areas. However, whether it is drug application or intestinal hole filling, hydrogels need to be firmly adhered to the affected area under a dynamic environment. The common hydrogel viscosity detection method can only detect the static adhesion strength between the hydrogel and the adhesion substrate. The dynamic adhesion strength can only be found and detected through actual clinical applications, which greatly increases the R&D cost of hydrogel patches. For the field of hydrogel electronics, hydrogel patches are also a very promising product. Hydrogels have a high bending limit and good tensile properties, which allows them to fit well with the skin. Not only that, hydrogels can be combined with conductive materials to prepare advanced hydrogel conductive sensors, which can accurately monitor tiny movements of the human body and are an important direction for the future development of hydrogel electronics. However, the premise for hydrogel electronic sensors to achieve precise control of human movements is to ensure that the hydrogel patch is completely attached to the human skin and does not fall off. Therefore, it is necessary to perform dynamic adhesion strength tests on hydrogel patches. Other emerging hydrogel materials are also similar to the application scenarios of hydrogels, so dynamic adhesion performance tests are required.

[0003] The adhesion performance of hydrogel patches applied to the human body is different from that of hydrogel patches applied to the surface of hard objects. Human skin and organs are soft and ductile, so the dynamic adhesion performance of hydrogel patches on human skin and organs needs to be tested before application.

[0004] Existing adhesion strength test methods include: (1) Determination of initial adhesion: Using an adhesion tester, the initial adhesion of plasters and patches is determined by the rolling ball ramp stop method. This method is to let steel balls of different sizes roll over the sticky surface of the patch and evaluate its initial adhesion based on the largest ball size that can be adhered. (2) Determination of sustained adhesion: Also using an adhesion tester, stick the sticky surface of the patch to the surface of the test plate, place it vertically, and hang a weight of a specified mass along the length direction. Record the time it takes for the patch to slide until it falls off or the distance it moves within a certain period of time to reflect the ability of the plaster or patch paste to resist deformation or fracture caused by persistent external forces. (3) Determination of peel strength: Using the 180° peel strength test method, use a tensile testing machine to continuously peel the patch and the test plate or polyester film at a certain speed, obtain the peel curve through a drawing device that records the peel load, and calculate the peel strength. (4) Determination of adhesion: Applicable to larger-sized plasters and patches. Pressure is applied to the patch through a specific test device and a pressure roller to measure the adhesion of the patch after it comes into contact with the skin. (5) Electrophysiological performance test: For patches with electrophysiological monitoring functions, such as electrocardiogram (ECG) or electromyogram (EMG) monitoring patches, the adhesion performance of the patch can be indirectly evaluated by connecting to the corresponding monitoring equipment and recording the clarity and stability of the signal. Most of these methods can only perform static adhesion tests and cannot detect the degree of sustained adhesion of hydrogel patches under dynamic conditions, especially complex movements. The electrophysiological performance test method can only test patches with electrophysiological monitoring functions and cannot detect hydrogel drug-loaded patches and hydrogel organ patches. Summary of the invention

[0005] The purpose of the present invention is to provide a method for detecting the dynamic adhesion performance of a hydrogel patch in order to solve the problem that the prior art is unable to detect the sustained adhesion degree of a hydrogel patch under dynamic conditions, especially complex movements. By detecting the dynamic adhesion performance of the hydrogel patch through bionic movements and combining it with the traditional static adhesion performance detection method, the comprehensive adhesion performance of the tested hydrogel patch can be fully evaluated.

[0006] The present invention achieves the above-mentioned purpose through the following technical scheme: a method for detecting the dynamic adhesion performance of a hydrogel patch, including a method for detecting the adhesion performance of a hydrogel patch under peristaltic motion and a method for detecting the adhesion performance of a hydrogel patch under bending, torsion and extension motion. The method for detecting the adhesion performance of a hydrogel patch under peristaltic motion comprises the following steps: S11, pre-treating the tested hydrogel patch, cutting the tested hydrogel patch into thin slices of a certain size, and pasting a circular iron sheet in the center of one side where the hydrogel patch and the peristaltic motion dynamic detection device are pasted; S12, attaching the hydrogel patch to be tested, extending the pretreated patch to be tested from the port into the peristaltic motion dynamic detection device through a clamping tool, and attaching the peristaltic motion dynamic detection device to the simulated affected area position set by the bionic detection device; S13, simulating peristaltic motion, after pasting the patch to be tested to the affected part, starting the peristaltic motion detection device to simulate the peristaltic motion of the organ muscle, and simultaneously starting the electromagnetic induction detection device outside the bionic detection device, after the bionic detection device has worked for a certain period of time, using the electromagnetic induction detection device to detect whether the circular patch is still at the affected part and has not moved, if the circular patch has not moved, it is proved that the dynamic adhesion force of the peristaltic motion of the patch to be tested meets the design requirements of the peristaltic patch for stretching the organ muscle; S14, fluid impact test, based on step S13, connecting the two ends of the peristaltic motion detection device to pipes, inputting a thick liquid with a pH value of 5-7 into the peristaltic motion detection device through the pipes, and during this process, always detecting the position of the circular iron piece through the electromagnetic induction detection device. If the circular patch does not move after a period of time, it proves that the dynamic adhesion performance of the hydrogel patch meets the requirements of the intestinal wall peristaltic motion patch; The method for testing the adhesion performance of the hydrogel patch under bending, twisting and stretching motions comprises the following steps: S21, pre-treating the hydrogel patch to be tested, and pre-cutting the hydrogel patch to be tested into slices of a certain size; S22, attaching the hydrogel patch to be tested, attaching the pretreated patch to be tested to the surface of the dynamic adhesion test device through a clamping tool, and applying initial pressure to ensure that the hydrogel patch is completely attached to the surface of the dynamic adhesion test device; S23, simulating joint pulling and contraction action detection, starting the dynamic adhesion force detection device to simulate the joint bending, twisting and stretching action, and making the dynamic adhesion force detection device bend back and forth at a certain angle continuously. After working for a period of time, the position of the hydrogel patch is detected by the electromagnetic induction detection device. If the hydrogel patch is still attached to the surface of the dynamic adhesion force detection device, the joint bending dynamic adhesion requirement is met; S24, simulate joint rotation and swinging motion detection, start joint rotation motion simulation while the dynamic adhesion force detection device simulates joint bending, twisting and stretching motion, at this time the joint motion is rotation + bending, simulating the "circling" motion of the human wrist, after repeating this motion for a period of time, the dynamic adhesion force detection device starts to swing back and forth 15°, after swinging for a period of time, detect the position of the hydrogel patch through the electromagnetic induction detection device, if the hydrogel patch is still attached to the surface of the bionic joint and has not fallen off, then the dynamic adhesion requirement of the surface skin at the human joint is met.

[0007] As a further solution of the present invention: the hydrogel patch to be tested is pre-cut into thin slices of 20 mm×20 mm×2 mm.

[0008] As a further solution of the present invention: the dimensions of the circular iron sheet used are: 5 mm in diameter and 0.5 mm in thickness.

[0009] As a further solution of the present invention: the peristaltic motion dynamic detection device adopted in the method for detecting the adhesion performance of the hydrogel patch under the peristaltic motion includes an annular air capsule and an inflation tube. A plurality of annular air capsules are arranged side by side, each of which is connected to an inflation tube, and the outer side surface of each annular air capsule is a hard outer shell, and the inner side surface of each annular air capsule is an elastic rubber stretch membrane.

[0010] As a further solution of the present invention: the bionic detection device includes but is not limited to human body movements such as walking, lying on your back and jumping, and the design requirements of the peristaltic movement of the tested patch specifically include: After the bionic detection device has been working for 1 hour, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion of the tested patch's peristaltic motion has reached the design requirements for peristaltic motion patches applied to small-amplitude stretching organs such as the heart and spleen; After the bionic detection device has been working for 2 hours, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion force of the peristaltic motion of the tested patch has reached the design requirements for muscle peristaltic patches used in large-scale contraction and extension organs such as the stomach, intestines, and bladder.

[0011] As a further solution of the present invention: a method for detecting the adhesion performance of a hydrogel patch under peristaltic motion and an electromagnetic induction detection device used in the method for detecting the adhesion performance include a conductive medium and a conductivity tester, and the conductive medium includes but is not limited to conductive hydrogel, an extremely thin metal sheet or a conductive new material film, the conductive medium is placed under the hydrogel patch to be tested, and wires are connected at both ends of the hydrogel patch, and the wires connect a power supply and a conductivity tester.

[0012] As a further solution of the present invention: the dynamic adhesion detection device adopted in the method for detecting the adhesion performance of the hydrogel patch under bending, torsion and extension action includes a cylindrical cylinder, a hinge, a rotating ring and a soft rubber plate. There are two cylindrical cylinders, and the two cylindrical cylinders are connected by a hinge. A rotating ring is mounted on the body of the cylindrical cylinder, and a soft rubber plate is connected between the two rotating rings.

[0013] The beneficial effects of the present invention are as follows: the present invention uses bionics to invent two devices for detecting the dynamic adhesion performance of the hydrogel patch; including imitating the bending, twisting, stretching, rotating, swinging and other movements of the wrist; imitating the creeping and stretching movements of the organ muscles; based on the above two devices, a method for detecting the dynamic adhesion performance of the hydrogel patch is invented, during creeping movements, the electromagnetic induction device detects the position of the patch in the device in real time to determine whether the patch falls off; during bending, twisting and stretching movements, a layer of extremely thin conductive medium is attached between the patch and the detection device, and a wire is used to connect the two sides of the hydrogel patch to the power supply and the conductivity tester, and the conductivity curve is drawn to determine the adhesion between the hydrogel patch and the device; By imitating the bending and rotating action of the human wrist through a bionic method, the bending and rotating action of the hydrogel patch adhering to the human wrist is simulated, so as to test the dynamic adhesion performance of the hydrogel patch under the expansion and contraction of the human skin surface; imitating the peristaltic action of the organ muscle, simulating the liquid impact of the hydrogel patch when it adheres inside the organ, and the influence of the peristalsis of the intestinal wall on the adhesion effect of the hydrogel patch, so as to test the dynamic adhesion performance of the hydrogel patch on the wet surface of the organ; imitating the contraction and relaxation action of human and animal skin, simulating the compression and stretching of the hydrogel patch adhering to the human skin. By simulating the above actions, the hydrogel patch can obtain the effect of the actual working situation through simulation in the research and development stage, and the dynamic adhesion performance of the hydrogel patch can be detected without clinical trials. The present invention simulates the peristaltic action of the organ muscle and the bending, twisting, stretching and contraction action of the skin at the joints of the human body, greatly reducing the research and development test cost of the hydrogel patch, and the problem of insufficient adhesion can be found without clinical treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the detection process of the present invention; Figure 2 It is a schematic diagram of the three-dimensional structure of the peristaltic motion dynamic detection device of the present invention; Figure 3 It is a schematic diagram of the detection state structure of the peristaltic motion dynamic detection device of the present invention; Figure 4 It is a schematic diagram of the bending and stretching action structure of the dynamic adhesion force detection device of the present invention; Figure 5 It is a schematic diagram of the swinging action structure of the dynamic adhesion force detection device of the present invention; Figure 6 It is a schematic diagram of the twisting action structure of the dynamic adhesion force detection device of the present invention.

[0015] In the figure: 1. annular air chamber, 2. inflatable tube, 3. cylindrical tube, 4. hinge, 5. rotating ring, 6. soft rubber sheet. DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0017] Embodiment 1, as Figures 1 to 6 As shown, a method for detecting the dynamic adhesion performance of a hydrogel patch includes a method for detecting the adhesion performance of a hydrogel patch under creeping motion and a method for detecting the adhesion performance of a hydrogel patch under bending, twisting and stretching motion. The method for detecting the adhesion performance of a hydrogel patch under creeping motion includes the following steps: S11, pre-treating the tested hydrogel patch, cutting the tested hydrogel patch into thin slices of a certain size, and pasting a circular iron sheet in the center of one side where the hydrogel patch and the peristaltic motion dynamic detection device are pasted; S12, attaching the hydrogel patch to be tested, extending the pretreated patch to be tested from the port into the peristaltic motion dynamic detection device through a clamping tool, and attaching the peristaltic motion dynamic detection device to the simulated affected area position set by the bionic detection device; S13, simulating peristaltic motion, after pasting the patch to be tested to the affected part, starting the peristaltic motion detection device to simulate the peristaltic motion of the organ muscle, and simultaneously starting the electromagnetic induction detection device outside the bionic detection device, after the bionic detection device has worked for a certain period of time, using the electromagnetic induction detection device to detect whether the circular patch is still at the affected part and has not moved, if the circular patch has not moved, it is proved that the dynamic adhesion force of the peristaltic motion of the patch to be tested meets the design requirements of the peristaltic patch for stretching the organ muscle; S14, fluid impact test. Organ muscle peristalsis and contraction are a major obstacle to the adhesion of the hydrogel patch to the organ. In addition, the inner wall of the intestine and the stomach are full of liquid. It is also necessary to simulate the flow of liquid in the intestine to see whether the hydrogel patch can still adhere firmly to the intestinal wall. On the basis of step S13, the two ends of the peristaltic motion detection device are connected to pipes, and a thick liquid with a pH value of 5-7 is input into the peristaltic motion detection device through the pipe. During this process, the position of the circular iron sheet is always detected by the electromagnetic induction detection device. After a period of time, if the circular patch does not move, it proves that the dynamic adhesion performance of the hydrogel patch meets the requirements of the intestinal wall peristaltic motion patch. The method for testing the adhesion performance of the hydrogel patch under bending, twisting and stretching motions comprises the following steps: S21, pre-treating the hydrogel patch to be tested, and pre-cutting the hydrogel patch to be tested into slices of a certain size; S22, attaching the hydrogel patch to be tested, attaching the pretreated patch to be tested to the surface of the dynamic adhesion test device through a clamping tool, and applying initial pressure to ensure that the hydrogel patch is completely attached to the surface of the dynamic adhesion test device; S23, simulating joint pulling and contraction action detection, starting the dynamic adhesion force detection device to simulate the joint bending, twisting and stretching action, and making the dynamic adhesion force detection device bend back and forth at a certain angle continuously. After working for a period of time, the position of the hydrogel patch is detected by the electromagnetic induction detection device. If the hydrogel patch is still attached to the surface of the dynamic adhesion force detection device, the joint bending dynamic adhesion requirement is met; S24, simulate joint rotation and swinging motion detection, start joint rotation motion simulation while the dynamic adhesion force detection device simulates joint bending, twisting and stretching motion, at this time the joint motion is rotation + bending, simulating the "circling" motion of the human wrist, this motion is repeated for a period of time, and then the dynamic adhesion force detection device starts to swing back and forth 15°, after swinging for a period of time, the position of the hydrogel patch is detected by the electromagnetic induction detection device, if the hydrogel patch is still attached to the bionic joint surface and has not fallen off, then the dynamic adhesion requirement of the skin on the surface of the human joint is met, because the dynamic pulling situation of the skin surface of the joint part such as the wrist is relatively complicated, so it is only necessary to ensure that the patch will not fall off during complex movements at the joint, and then this hydrogel patch meets the dynamic adhesion requirement of the human skin surface.

[0018] The dynamic adhesion performance index of the hydrogel patch is: The hydrogel patch must be able to peristalsize 3,000 times without falling off in a peristaltic device without being filled with water, and thus meet the dynamic adhesion performance requirements for adhering to the surface of human organs.

[0019] The hydrogel patch must be able to withstand 6,000 repeated peristalsis cycles in a continuous flushing state in a peristaltic device without falling off, thus meeting the dynamic adhesion performance requirements for adhesion inside human organs.

[0020] The hydrogel patch must be able to withstand bending at ±30° for 2,000 times on the surface of a bending and torsion expansion device without falling off, which means it can meet the dynamic adhesion performance requirements for adhesion to the front side of the human hip joint and ankle joint, and also meet the dynamic adhesion performance requirements for adhesion to the surface of human skin with small expansion and contraction.

[0021] The hydrogel patch must be able to withstand bending at ±30° for 2000 times and swinging at ±10° for 2000 times on the surface of the bending and torsion expansion device without falling off, which can meet the dynamic adhesion performance requirements for adhesion to the human ball and socket joint.

[0022] Embodiment 2, in addition to all the technical features of Embodiment 1, this embodiment also includes: pre-cutting the hydrogel patch to be tested into a sheet of 20mm×20mm×2mm. The size of the circular iron sheet used is: 5mm in diameter and 0.5mm in thickness.

[0023] The adhesion performance detection method of the hydrogel patch under the peristaltic motion and the electromagnetic induction detection device used in the adhesion performance detection method include a conductive medium and a conductivity tester, and the conductive medium includes but is not limited to conductive hydrogel, an extremely thin metal sheet or a conductive new material film. The conductive medium is placed under the hydrogel patch to be tested, and wires are connected at both ends of the hydrogel patch. The wires connect the power supply and the conductivity tester. During normal cyclic bending, torsion and expansion movements, the conductivity curve should be a periodic curve. When the hydrogel patch partially falls off, the conductivity curve will undergo an overall change. When it falls off completely, the conductivity tester is not powered on. This method can accurately and digitally characterize and judge the adhesion state of the hydrogel patch.

[0024] Embodiment 3. In addition to all the technical features of Embodiment 1, this embodiment also includes: a peristaltic motion dynamic detection device used in the method for detecting the adhesion performance of the hydrogel patch under peristaltic motion includes an annular air capsule 1 and an inflation tube 2. A plurality of annular air capsules 1 are arranged side by side, each annular air capsule 1 is connected to an inflation tube 2, and the outer side surface of each annular air capsule 1 is a hard shell, and the inner side surface of each annular air capsule 1 is an elastic rubber stretch film. The hard shell can limit the deformation of the outer side surface of the annular air capsule 1, so that the annular air capsule 1 can bulge inward after inflation, and the internal plastic stretch film can be deformed by inflating the air capsules in turn. Therefore, the peristaltic motion of the muscle can be simulated by inflating the inflation tube 2 in sequence.

[0025] Furthermore, the bionic detection device includes but is not limited to human body movements such as walking, lying on your back and jumping, and the design requirements for the peristaltic movement of the patch under test specifically include: After the bionic detection device has been working for 1 hour, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion of the tested patch's peristaltic motion has reached the design requirements for peristaltic motion patches applied to small-amplitude stretching organs such as the heart and spleen; After the bionic detection device has been working for 2 hours, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion force of the peristaltic motion of the tested patch has reached the design requirements for muscle peristaltic patches used in large-scale contraction and extension organs such as the stomach, intestines, and bladder.

[0026] Embodiment 4. In addition to all the technical features of Embodiment 1, this embodiment also includes: a dynamic adhesion force detection device used in the method for detecting the adhesion performance of the hydrogel patch under bending, torsion and extension action includes a cylindrical tube 3, a hinge 4, a rotating ring 5 and a soft rubber plate 6. Two cylindrical tubes 3 are provided, and the two cylindrical tubes 3 are connected by a hinge 4. A rotating ring 5 is sleeved on the body of the cylindrical tube 3, and a soft rubber plate 6 is connected between the two rotating rings 5. The two cylindrical tubes 3 are connected to the hinge 4 to simulate the joints of the human body, and then the two cylindrical tubes 3 can be bent, swung or twisted to simulate the bending action, swinging action or twisting action at the joint, that is, the dynamic adhesion performance of the hydrogel patch can be detected in various situations where it is placed on the joint.

[0027] By imitating the bending and rotating movements of the human wrist through bionic methods, the bending and rotating movements of the hydrogel patch attached to the human wrist are simulated, so as to test the dynamic adhesion performance of the hydrogel patch under the expansion and contraction of the human skin surface; by imitating the peristalsis of organ muscles, the liquid impact on the hydrogel patch when it adheres inside the organ is simulated, as well as the influence of intestinal wall peristalsis on the adhesion effect of the hydrogel patch, so as to test the dynamic adhesion performance of the hydrogel patch on the moist surface of the organ; by imitating the contraction and relaxation of human and animal skin, the compression and stretching of the hydrogel patch when it adheres to the human skin are simulated.

[0028] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

[0029] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A method for detecting the dynamic adhesion performance of a hydrogel patch, including a method for detecting the adhesion performance of a hydrogel patch under creeping motion and a method for detecting the adhesion performance of a hydrogel patch under bending, torsion and extension motion, characterized in that: The method for detecting the adhesion performance of the hydrogel patch under peristaltic motion comprises the following steps: S11, pre-treating the tested hydrogel patch, cutting the tested hydrogel patch into thin slices of a certain size, and pasting a circular iron sheet in the center of one side where the hydrogel patch and the peristaltic motion dynamic detection device are pasted; S12, attaching the hydrogel patch to be tested, extending the pretreated patch to be tested from the port into the peristaltic motion dynamic detection device through a clamping tool, and attaching the peristaltic motion dynamic detection device to the simulated affected area position set by the bionic detection device; S13, simulating peristaltic motion, after pasting the patch to be tested to the affected part, starting the peristaltic motion detection device to simulate the peristaltic motion of the organ muscle, and simultaneously starting the electromagnetic induction detection device outside the bionic detection device, after the bionic detection device has worked for a certain period of time, using the electromagnetic induction detection device to detect whether the circular patch is still at the affected part and has not moved, if the circular patch has not moved, it is proved that the dynamic adhesion force of the peristaltic motion of the patch to be tested meets the design requirements of the peristaltic patch for stretching the organ muscle; S14, fluid impact test, based on step S13, connecting the two ends of the peristaltic motion detection device to pipes, inputting a thick liquid with a pH value of 5-7 into the peristaltic motion detection device through the pipes, and during this process, always detecting the position of the circular iron piece through the electromagnetic induction detection device. If the circular patch does not move after a period of time, it proves that the dynamic adhesion performance of the hydrogel patch meets the requirements of the intestinal wall peristaltic motion patch; The method for detecting the adhesion performance of the hydrogel patch under bending, twisting and stretching action comprises the following steps: S21, pre-treating the hydrogel patch to be tested, and pre-cutting the hydrogel patch to be tested into slices of a certain size; S22, attaching the hydrogel patch to be tested, attaching the pretreated patch to be tested to the surface of the dynamic adhesion test device through a clamping tool, and applying initial pressure to ensure that the hydrogel patch is completely attached to the surface of the dynamic adhesion test device; S23, simulating joint pulling and contraction action detection, starting the dynamic adhesion force detection device to simulate the joint bending, twisting and stretching action, and making the dynamic adhesion force detection device bend back and forth at a certain angle continuously. After working for a period of time, the position of the hydrogel patch is detected by the electromagnetic induction detection device. If the hydrogel patch is still attached to the surface of the dynamic adhesion force detection device, the joint bending dynamic adhesion requirement is met; S24, simulate joint rotation and swinging motion detection, start joint rotation motion simulation while the dynamic adhesion force detection device simulates joint bending, twisting and stretching motion, at this time the joint motion is rotation + bending, simulating the "circling" motion of the human wrist, after repeating this motion for a period of time, the dynamic adhesion force detection device starts to swing back and forth 15°, after swinging for a period of time, the position of the hydrogel patch is detected by the electromagnetic induction detection device, if the hydrogel patch is still attached to the bionic joint surface and has not fallen off, then the dynamic adhesion requirement of the surface skin at the human joint is met.

2. The detection method according to claim 1, characterized in that: In both S11 and S21, the hydrogel patch to be tested is pre-cut into thin sheets of 20 mm×20 mm×2 mm.

3. The detection method according to claim 1, characterized in that: In the step S11, the size of the circular iron sheet used is: 5 mm in diameter and 0.5 mm in thickness.

4. The detection method according to claim 1, characterized in that: The peristaltic motion dynamic detection device used in the method for detecting the adhesion performance of the hydrogel patch under peristaltic motion comprises a plurality of annular air capsules (1) and an inflation tube (2), wherein the annular air capsules (1) are arranged in a parallel manner, each of the annular air capsules (1) is connected to an inflation tube (2), and the outer side surface of each of the annular air capsules (1) is a hard shell, and the inner side surface of each of the annular air capsules (1) is an elastic rubber stretch film, and the deformation of the outer side surface of the annular air capsule (1) can be limited by the hard shell, so that the annular air capsule (1) can swell inward after being inflated, and the internal plastic stretch film can be deformed by inflating the air capsules in turn, so that the peristaltic motion of the muscle can be simulated by inflating the inflation tubes (2) in sequence.

5. The detection method according to claim 1, characterized in that: In S13, the bionic detection device includes but is not limited to bionic human movements such as walking, lying on your back and jumping, and the design requirements for the peristaltic movement of the patch under test specifically include: After the bionic detection device has been working for 1 hour, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion of the tested patch's peristaltic motion has reached the design requirements for peristaltic motion patches applied to small-amplitude stretching organs such as the heart and spleen; After the bionic detection device has been working for 2 hours, if the circular patch detected by the electromagnetic induction detection device is still at the affected area and has not moved, it proves that the dynamic adhesion force of the peristaltic motion of the tested patch has reached the design requirements for muscle peristaltic patches used in large-scale contraction and extension organs such as the stomach, intestines, and bladder.

6. The detection method according to claim 1, characterized in that: The adhesion performance detection method of the hydrogel patch under peristaltic motion and the electromagnetic induction detection device used in the adhesion performance detection method include a conductive medium and a conductivity tester, and the conductive medium includes but is not limited to conductive hydrogel, an extremely thin metal sheet or a conductive new material film. The conductive medium is placed under the hydrogel patch to be tested, and wires are connected at both ends of the hydrogel patch, which connect a power supply and a conductivity tester.

7. The detection method according to claim 1, characterized in that: The dynamic adhesion force detection device used in the method for detecting the adhesion performance of the hydrogel patch under bending, twisting and stretching motions comprises a cylindrical tube (3), a hinge (4), a rotating ring (5) and a soft rubber plate (6). The cylindrical tubes (3) are provided with two, and the two cylindrical tubes (3) are connected via a hinge (4). The cylindrical tubes (3) are sleeved with a rotating ring (5), and a soft rubber plate (6) is connected between the two rotating rings (5). The two cylindrical tubes (3) are connected to the hinge (4) to simulate the joints of the human body. The two cylindrical tubes (3) can be bent, swung or twisted to simulate the bending, swinging or twisting motion of the joints, so that the dynamic adhesion performance detection of the hydrogel patch in various situations where it is attached to the joints can be realized.

Images