Composition and application thereof, toothpaste and toothpaste preparation method

Abstract

The invention provides a composition and application thereof, toothpaste and a toothpaste preparation method, the composition comprises functional components, a thickening agent and a stabilizer, the functional components comprise percarbonate, persulfate and dihydric pyrophosphate, the thickening agent comprises polyethylene glycol 3350, polyvinylpyrrolidone K90 and sodium magnesium lithium silicate, and the stabilizer comprises polyethylene glycol 3350, polyvinylpyrrolidone K90 and sodium magnesium lithium silicate. The stabilizer comprises two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate. The functional components, the thickening agent and the stabilizing agent are compounded to play a synergistic role, so that the compatibility of the functional components and the thickening agent is improved, and the problems of water outlet and paste alkene at a tube opening of the toothpaste are relieved; meanwhile, the pH value in the using process is reduced, and the irritation to oral mucosa is reduced.

Description

Technical Field

[0001] The present application relates to the technical field of daily chemical products, and in particular to a composition and its application, a toothpaste and a toothpaste preparation method. Background Art

[0002] According to their functions, toothpaste can be divided into categories such as whitening, gum protection, anti-allergy, and anti-caries. Among them, whitening toothpaste occupies the first place in the domestic oral care market share, and consumers have a strong demand for teeth whitening. At present, most whitening toothpastes on the market are mainly for stain removal, and high-cleaning abrasives, chelating agents, etc. are commonly used. Peroxide is one of the ingredients that has been proven to have good stain removal and whitening effects, and its stain removal and whitening effects are more prominent than conventional chelating agents. However, there are very few toothpastes containing peroxide on the market, and during use, it is easy for peroxide to be incompatible with the thickener in the toothpaste formula, water leaking from the toothpaste tube, and the paste being thin. At the same time, during the use of anhydrous peroxide toothpaste, as the toothpaste contacts saliva, hydrogen peroxide is released, causing the pH value to rise rapidly in a short period of time, which is highly irritating to the oral mucosa to a certain extent. Summary of the invention

[0003] Based on this, the present application provides a composition and its application, a toothpaste and a method for preparing a toothpaste, so as to improve the compatibility of the effective ingredients with the thickener, alleviate the problems of water leakage from the toothpaste tube and paste olefins; at the same time, reduce the pH value during use and reduce irritation to the oral mucosa.

[0004] The first aspect of the present application provides a composition, comprising functional ingredients, a thickener and a stabilizer, wherein the functional ingredients include percarbonate, persulfate and dihydrogen pyrophosphate, the thickener includes polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate, and the stabilizer includes two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

[0005] In some embodiments, the mass ratio of polyethylene glycol 3350, lithium sodium magnesium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.3-1), and can be (2-6):(0.5-0.7):(0.3-1); and / or

[0006] The mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the functional ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5); and / or

[0007] The effective ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

[0008] In some embodiments, the mass ratio of the functional ingredient, the thickener and the stabilizer is (0.6-4.5):(3-7):(0.2-3).

[0009] The second aspect of the present application provides a use of the composition of the first aspect of the present application in the preparation of toothpaste.

[0010] The third aspect of the present application provides a toothpaste, which includes a composition, wherein the composition includes functional ingredients, a thickener and a stabilizer, wherein the functional ingredients include percarbonate, persulfate and dihydrogen pyrophosphate, the thickener includes polyethylene glycol 3350, polyvinyl pyrrolidone K90 and lithium magnesium sodium silicate, and the stabilizer includes two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

[0011] In some embodiments, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.3-1), and can be optionally (2-6):(0.5-0.7):(0.3-1).

[0012] In some embodiments, the mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the functional ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5); and / or

[0013] The effective ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

[0014] In some embodiments, the toothpaste further comprises a moisturizer, an abrasive, a foaming agent, and a flavor;

[0015] Optionally, the toothpaste comprises, by weight:

[0016] 0.6 to 4.5 parts of the functional ingredient, 3 to 7 parts of the thickener, 0.2 to 3 parts of the stabilizer, 34 to 50 parts of the moisturizer, 40 to 55 parts of the friction agent, 1.5 to 2 parts of the foaming agent and 0.5 to 1 part of the fragrance.

[0017] In some embodiments, the humectant includes one or more of polyethylene glycol 300 and polyethylene glycol 400;

[0018] Optionally, the humectant excludes glycerin, propylene glycol and sorbitol.

[0019] In some embodiments, the abrasive comprises one or more of the group consisting of calcium pyrophosphate and calcium carbonate; and / or

[0020] The foaming agent includes one or more of sodium lauryl sulfate, cocamidopropyl betaine and sodium methyl cocoyl taurate; and / or

[0021] The flavor includes any one of peppermint flavor, spearmint flavor and wintergreen flavor.

[0022] In some embodiments, the toothpaste is an anhydrous toothpaste.

[0023] The fourth aspect of the present application provides a method for preparing a toothpaste, the toothpaste comprising functional ingredients, a thickener, a stabilizer, a moisturizer, an abrasive, a foaming agent and a flavor; the functional ingredients comprising percarbonate, persulfate and dihydrogen pyrophosphate, the stabilizer comprising two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate, the thickener comprising polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate; the preparation method comprising the following steps:

[0024] preparing a melt A comprising polyethylene glycol 3350 and the humectant;

[0025] The cooled molten liquid A is mixed with polyvinyl pyrrolidone K90 to prepare a molten liquid B;

[0026] The melt B, the friction agent, the stabilizer and sodium magnesium lithium silicate are mixed to prepare a paste;

[0027] The functional ingredients, the foaming agent and the flavor are sequentially added into the paste to prepare the toothpaste.

[0028] In the above-mentioned composition, the compound of percarbonate, persulfate and dihydrogen pyrophosphate is used as the functional ingredient, which can effectively increase the release rate of hydrogen peroxide during use, and reduce the pH value during use, while protecting the oral mucosa while exerting its stain removal and whitening effect to the greatest extent; and it can also improve the storage stability of peroxide. The compound of polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate is used as a thickener to give the toothpaste formula good stability, solving the problem of easy water separation of toothpaste and too high or too low consistency. Using two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate as stabilizers can improve the stability of the functional ingredients in the formula, thereby improving the retention rate of active oxygen content. In summary, by compounding the functional ingredients, thickeners and stabilizers, a synergistic effect is exerted, the compatibility of the functional ingredients and thickeners is improved, and the problems of water discharge and paste ene at the toothpaste tube mouth are alleviated; at the same time, the pH value during use is reduced, and the irritation to the oral mucosa is reduced. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions in the embodiments of the present application and to more completely understand the present application and its beneficial effects, the following is a brief introduction to the drawings required for the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application, and those skilled in the art can obtain other drawings based on these drawings without creative work.

[0030] Figure 1 The appearance of the toothpaste in Example 3 and Comparative Example 5;

[0031] Figure 2 This is the appearance of the toothpaste paste in Example 3 and Comparative Example 5. DETAILED DESCRIPTION

[0032] For ease of understanding of the present invention, the application will be described more fully below with reference to relevant embodiments. The following provides preferred embodiments of the application. However, the application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the application more thorough and comprehensive.

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0034] The terms "and / or", "or / and", and "and / or" used herein include any one of two or more related listed items, and also include any and all combinations of the related listed items, wherein the any and all combinations include any combination of two related listed items, any more related listed items, or all related listed items. It should be noted that when at least three items are connected by at least two conjunctions selected from "and / or", "or / and", and "and / or", it should be understood that in the present application, the technical solution undoubtedly includes technical solutions connected by "logical and", and also undoubtedly includes technical solutions connected by "logical or".

[0035] In the present application, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0036] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are deemed to be continuous and include the minimum and maximum values ​​of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values ​​of the range is included. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be merged. In other words, unless otherwise specified, all ranges disclosed herein should be understood to include any and all subranges included therein.

[0037] Only some numerical ranges are specifically disclosed herein. However, any lower limit can be combined with any upper limit to form an unspecified range; and any lower limit can be combined with other lower limits to form an unspecified range, and likewise any upper limit can be combined with any other upper limit to form an unspecified range. In addition, each separately disclosed point or single value can itself be combined as a lower limit or upper limit with any other point or single value or with other lower limits or upper limits to form an unspecified range.

[0038] The temperature parameters in this application, unless otherwise specified, allow both constant temperature treatment and treatment within a certain temperature range. The constant temperature treatment allows the temperature to fluctuate within the accuracy range controlled by the instrument. Fluctuations within the range of ±5°C, ±4°C, ±3°C, ±2°C, and ±1°C are allowed.

[0039] Herein, the “suitable” mentioned in “suitable combination”, “suitable method”, “any suitable method”, etc., shall be based on the ability to implement the technical solution of this application, solve the technical problems of this application, and achieve the expected technical effects of this application.

[0040] In the present application, "further", "further", "particularly" and the like are used for descriptive purposes to indicate differences in content, but should not be construed as limiting the scope of protection of the present application.

[0041] In this application, "optionally", "optional", and "optional" mean optional or dispensable, that is, any one of the two parallel schemes of "yes" or "no". If multiple "options" appear in a technical solution, unless otherwise specified and there is no contradiction or mutual restriction, each "optional" is independent.

[0042] In the description of the application, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0043] Unless otherwise specified, all formulations and tests herein took place at 25°C.

[0044] As used herein, "includes," "comprising," "containing," "having," or other variations thereof are intended to encompass non-closed inclusions, and no distinction is made between these terms. The term "comprising" means that other steps and ingredients that do not affect the end result may be added. The compositions and methods / processes of the present invention comprise, consist of, and consist essentially of the essential elements and limitations described herein, as well as any additional or optional ingredients, components, steps, or limitations described herein. As used herein, no distinction is made between the terms "efficacy," "performance," "effect," and "efficacy."

[0045] If there is no special description, all embodiments and optional embodiments of the present application can be combined with each other to form a new technical solution. If there is no special description, all technical features and optional technical features of the present application can be combined with each other to form a new technical solution.

[0046] If there is no special explanation, all the steps of the present application can be performed sequentially or randomly, preferably sequentially.

[0047] There are few toothpastes containing peroxide on the market. During use, the peroxide is prone to incompatibility with the thickener in the toothpaste formula, water comes out of the toothpaste tube, and the paste is thin. At the same time, anhydrous peroxide toothpaste releases hydrogen peroxide as the toothpaste contacts saliva during use, resulting in a rapid increase in the pH value in a short period of time, which is highly irritating to the oral mucosa to a certain extent. In addition, peroxide toothpaste also has the problem of rapid decrease in active oxygen content and short retention period. Therefore, the present application adopts specific substances as functional ingredients, thickeners and stabilizers respectively, and by compounding the functional ingredients, thickeners and stabilizers, a synergistic effect is exerted, the compatibility of the functional ingredients and thickeners is improved, and the problems of water coming out of the toothpaste tube and the thin paste are alleviated; at the same time, the pH value during use is reduced, and the irritation to the oral mucosa is reduced.

[0048] One or more embodiments of the present application provide a composition, which includes an effective ingredient, a thickener and a stabilizer, wherein the effective ingredient includes one or more of percarbonate, persulfate and dihydrogen pyrophosphate, the thickener includes polyethylene glycol 3350 and one or more of polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate, and the stabilizer includes two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

[0049] It should be noted that the "peroxide" mentioned in the context is not limited to compounds containing peroxide groups (-OO-), such as metal peroxides (eg, sodium peroxide Na2O2, barium peroxide BaO2, etc.), hydrogen peroxide, peracids and their salts, etc. As long as the compound can produce peroxide groups (-OO-) under certain conditions, for example, percarbonate that can release hydrogen peroxide when in contact with water, it belongs to the category of peroxide.

[0050] Polyethylene glycol 3350 is a solid particle at room temperature with a melting point of 53°C-56°C. Based on this characteristic of polyethylene glycol 3350, polyethylene glycol 3350 can be first dispersed in low molecular weight polyethylene glycol during the toothpaste preparation process, and then the viscosity-enhancing formula system can be achieved by cooling, which provides a new idea for the preparation of toothpaste. When polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate are used as thickeners, the toothpaste formula has good suspension performance and stability.

[0051] In toothpaste, functional ingredients such as percarbonate and persulfate are easy to interact with moisturizers and thickeners in the formula, which will cause problems such as water leakage and tube swelling in the paste, which not only affects the stability of the paste but also reduces the effectiveness of percarbonate. In this application, by adding a stabilizer, the storage stability of the functional ingredients is significantly improved.

[0052] Sodium percarbonate becomes solid hydrogen peroxide, which can release hydrogen peroxide when it meets water, thereby achieving bleaching effect, but sodium percarbonate needs to be at about 60°C to quickly release active oxygen when it meets water. Therefore, most daily chemical products using sodium percarbonate will add tetraacetylethylenediamine (TAED) as an activator. However, when sodium percarbonate and TAED are added to the anhydrous toothpaste formula at the same time, the formula is prone to flatulence. In this application, the release of active oxygen can be accelerated without adding an activator, and the problem of too fast pH value rise during the use of toothpaste can be solved.

[0053] Understandably, in the composition of the present application, the use of percarbonate, persulfate and dihydrogen pyrophosphate as functional ingredients can effectively increase the release rate of hydrogen peroxide during use, while reducing the pH value during use, while protecting the oral mucosa while exerting its stain removal and whitening effect to the greatest extent; and it can also improve the storage stability of peroxide. Polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate are used as thickeners to give the toothpaste formula good stability, solving the problem of easy water separation, high or low consistency of toothpaste. Using two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate as stabilizers can improve the stability of the functional ingredients in the formula, thereby improving the retention rate of active oxygen content. In summary, by compounding the functional ingredients, thickeners and stabilizers, a synergistic effect is exerted, the compatibility of the functional ingredients and thickeners is improved, and the problems of water discharge and paste ene at the toothpaste tube mouth are alleviated; at the same time, the pH value during use is reduced, and the irritation to the oral mucosa is reduced.

[0054] In some embodiments, the mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.3-1); when the mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener is within the above range, it is beneficial to further improve the suspension performance and stability of the toothpaste formula.

[0055] As an example, the mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener can be limited to (2-6): (0.3-0.8): (0.3-1), (2-3): (0.5-0.7): (0.5-1) , (3-6):(0.3-0.8):(0.3-0.5), (2-5.5):(0.33-0.8):(0.33-1), (2-5):(0.35-0.78):(0.35-1), (2-4.5):(0.38-0.76):(0.38-1), (2-4):(0.4-0.74):(0.4-1), (2-3.5):(0.45-0.72):(0.45-1), (2-3):(0.5-0.7):(0.5-1), (2-6):(0.3-0.8):(0.5-1), (2-6):(0.5-0.7):(0.5-1) or (2-6):(0.5-0.7):(0.3-1), etc.

[0056] In some optional embodiments, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.5-1).

[0057] As a possible implementation manner, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.5-0.7):(0.3-1).

[0058] In some embodiments, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.5-0.7):(0.5-1).

[0059] In some optional embodiments, the functional ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

[0060] In some optional embodiments, the mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the functional ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5). This is conducive to further improving the release rate of active oxygen and solving the problem of too fast pH rise during the use of toothpaste.

[0061] As a non-limiting example, the mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the effective ingredients can be but is not limited to (0.4-1.5):(0.1-0.5):(0.1-2.5), (0.8-1.5):(0.2-0.5):(0.1-2), (0.4-0.8):(0.4-0.5):(0.1-1), (0.8-1.5):(0.1-0.4):(1-2.5), (0.4-0.8):(0.1-0.2):(1-2) or (0.4-1.5):(0.2-0.4):(2-2.5), etc.

[0062] In some embodiments, the mass ratio of the effective ingredient, the thickener and the stabilizer is (0.6-4.5):(3-7):(0.2-3); for example, it can be but not limited to (0.6-4.5):(3-7):(0.2-3), (0.6-3):(3-4.5):(0.2-1.6), (0.6-1.8):(4.5-7):(0.2-3), (1.8-4.5):(4.5-7):(1.6-3), (1.8-3):(3-4.5):(1.6-3) or (3-4.5):(3-7):(0.2-1.6), etc.

[0063] One or more embodiments of the present application provide a use of the above-mentioned composition in preparing toothpaste.

[0064] One or more embodiments of the present application provide a toothpaste comprising a composition, wherein the composition comprises functional ingredients, a thickener and a stabilizer, wherein the functional ingredients comprise percarbonate, persulfate and dihydrogen pyrophosphate, the thickener comprises polyethylene glycol 3350, polyvinyl pyrrolidone K90 and lithium magnesium sodium silicate, and the stabilizer comprises two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

[0065] Understandably, the use of percarbonate, persulfate and dihydrogen pyrophosphate as functional ingredients can effectively increase the release rate of hydrogen peroxide during use, while reducing the pH value during use, while protecting the oral mucosa while exerting its stain removal and whitening effect to the greatest extent; and it can also improve the storage stability of peroxide. The use of polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate as thickeners can give the toothpaste formula good stability and solve the problem of easy water separation and too high or too low consistency of toothpaste. Using two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate as stabilizers can improve the stability of the functional ingredients in the formula, thereby improving the retention rate of active oxygen content. In summary, by compounding the functional ingredients, thickeners and stabilizers, a synergistic effect is exerted, the compatibility of the functional ingredients and thickeners is improved, and the problems of water discharge and paste ene at the toothpaste tube mouth are alleviated; at the same time, the pH value during use is reduced, reducing the irritation to the oral mucosa.

[0066] In some embodiments, the mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6): (0.3-0.8): (0.3-1). This is conducive to further improving the suspension performance and stability of the toothpaste formula.

[0067] As an example, the mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener can be limited to (2-6): (0.3-0.8): (0.3-1), (2-3): (0.5-0.7): (0.5-1) , (3-6):(0.3-0.8):(0.3-0.5), (2-5.5):(0.33-0.8):(0.33-1), (2-5):(0.35-0.78):(0.35-1), (2-4.5):(0.38-0.76):(0.38-1), (2-4):(0.4-0.74):(0.4-1), (2-3.5):(0.45-0.72):(0.45-1), (2-3):(0.5-0.7):(0.5-1), (2-6):(0.3-0.8):(0.5-1), (2-6):(0.5-0.7):(0.5-1) or (2-6):(0.5-0.7):(0.3-1), etc.

[0068] In some optional embodiments, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.5-1).

[0069] As a possible implementation manner, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.5-0.7):(0.3-1).

[0070] In some embodiments, the mass ratio of polyethylene glycol 3350, lithium magnesium sodium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.5-0.7):(0.5-1).

[0071] As a possible implementation method, the mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the effective ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5); thereby, it is beneficial to further increase the release rate of active oxygen and solve the problem of pH value rising too fast during the use of toothpaste.

[0072] As a non-limiting example, the mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the effective ingredients can be but is not limited to (0.4-1.5):(0.1-0.5):(0.1-2.5), (0.8-1.5):(0.2-0.5):(0.1-2), (0.4-0.8):(0.4-0.5):(0.1-1), (0.8-1.5):(0.1-0.4):(1-2.5), (0.4-0.8):(0.1-0.2):(1-2) or (0.4-1.5):(0.2-0.4):(2-2.5), etc.

[0073] As a possible implementation manner, the functional ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

[0074] In some embodiments, the toothpaste further comprises a moisturizer, an abrasive, a foaming agent and a flavor.

[0075] In some optional embodiments, the toothpaste includes, by mass: 0.6-4.5 parts of effective ingredients, 3-7 parts of thickeners, 0.2-3 parts of stabilizers, 34-50 parts of moisturizers, 40-55 parts of abrasives, 1.5-2 parts of foaming agents and 0.5-1 parts of flavors.

[0076] In terms of mass fraction, the mass fraction of the effective ingredients contained in the toothpaste can be but is not limited to 0.6 parts, 0.8 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or a range between any two of the above mass fractions.

[0077] In terms of mass fraction, the mass fraction of the thickener contained in the toothpaste can be but is not limited to 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts or a range between any two of the above mass fractions.

[0078] In terms of mass fraction, the mass fraction of the stabilizer contained in the toothpaste can be but is not limited to 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 parts, 1.5 parts, 2 parts, 2.5 parts, 3 parts or a range between any two of the above mass fractions.

[0079] In terms of parts by mass, the amount of moisturizer contained in the toothpaste can be but is not limited to 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 ​​parts, 49 parts, 50 parts or a range between any two of the above parts by mass.

[0080] In terms of parts by mass, the amount of abrasive contained in the toothpaste can be but is not limited to 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 ​​parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts or a range between any two of the above parts by mass.

[0081] In terms of mass fraction, the mass fraction of the foaming agent contained in the toothpaste can be but is not limited to 1.5 parts, 1.6 parts, 1.7 parts, 1.8 parts, 1.9 parts, 2 parts or a range between any two of the above mass fractions.

[0082] In terms of mass fraction, the mass fraction of the flavor contained in the toothpaste can be, but is not limited to, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, or a range between any two of the above mass fractions.

[0083] In some embodiments, the moisturizer includes one or more of polyethylene glycol 300 and polyethylene glycol 400. This is beneficial to further improve the stability of the toothpaste.

[0084] In some optional embodiments, the humectant does not include glycerin, propylene glycol and sorbitol. Thus, the flatulence problem caused by the combination of glycerin, propylene glycol and sorbitol with peroxide can be avoided.

[0085] In some embodiments, the abrasive includes one or more of the group consisting of calcium pyrophosphate and calcium carbonate.

[0086] As a possible implementation, the foaming agent includes one or more of sodium lauryl sulfate, cocamidopropyl betaine and sodium methyl cocoyl taurate.

[0087] In some optional embodiments, the flavor includes any one of mint flavor, spearmint flavor and wintergreen flavor.

[0088] In some embodiments, the toothpaste is an anhydrous toothpaste.

[0089] One or more embodiments of the present application provide a method for preparing a toothpaste, the toothpaste comprising functional ingredients, a thickener, a stabilizer, a moisturizer, an abrasive, a foaming agent and a flavor; the functional ingredients comprising percarbonate, persulfate and dihydrogen pyrophosphate, the stabilizer comprising two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate, the thickener comprising polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate; the preparation method comprises the following steps:

[0090] Prepare a melt A containing polyethylene glycol 3350 and a moisturizer; mix the cooled melt A with polyvinyl pyrrolidone K90 to prepare a melt B; mix the melt B, a friction agent, a stabilizer and sodium magnesium lithium silicate to prepare a paste; and sequentially add functional ingredients, a foaming agent and a flavor to the paste to prepare a toothpaste.

[0091] This preparation process is helpful for formula components to exert their advantages, improve synergistic effects, and facilitate mass production.

[0092] In some optional embodiments, the step of preparing a molten liquid A comprising polyethylene glycol 3350 and a humectant comprises: adding polyethylene glycol 3350 to polyethylene glycol 400, heating to 60° C.-80° C., and stirring until completely melted to obtain a molten liquid A.

[0093] As a possible implementation manner, the step of mixing the cooled molten liquid A and polyvinyl pyrrolidone K90 includes: after the molten liquid A is cooled to room temperature, polyvinyl pyrrolidone K90 is added thereto, and stirred until uniform.

[0094] In some embodiments, the step of mixing the melt B, the friction agent, the stabilizer and the sodium magnesium lithium silicate comprises: adding the friction agent, the stabilizer and the sodium magnesium lithium silicate to the melt B, and stirring for 30 min-40 min under vacuum conditions.

[0095] In some optional embodiments, the step of sequentially adding the functional ingredient, the foaming agent and the flavor into the paste comprises:

[0096] Add the effective ingredients to the paste and stir for 10-15 minutes; then add the foaming agent to the paste and stir for 10-15 minutes under vacuum conditions; finally add the first to the paste and stir for 10-15 minutes under vacuum conditions.

[0097] The technical scheme of the present invention is described in detail below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods for which specific conditions are not specified in the following embodiments are preferably referred to the guidance given in the present invention, and can also be based on the experimental manuals or conventional conditions in the art, or can also be based on the conditions recommended by the manufacturer, or refer to experimental methods known in the art.

[0098] In the following specific embodiments, the measured parameters of raw material components may have slight deviations within the range of weighing accuracy unless otherwise specified. For temperature and time parameters, acceptable deviations caused by instrument test accuracy or operation accuracy are allowed.

[0099] It should be noted that the raw materials used in the above embodiments and comparative examples can be purchased from the market.

[0100] 1. Preparation of toothpaste

[0101] 1. Prescription composition

[0102] The formulation compositions of Examples 1-7 are shown in Table 1. The formulation compositions of Comparative Examples 1-12 are shown in Table 2.

[0103] Table 1

[0104]

[0105] Table 2

[0106]

[0107] Among them, in Table 1 and Table 2, CAB represents cocamidopropyl betaine; K12 represents sodium lauryl sulfate.

[0108] Each "portion" mentioned above refers to 100g.

[0109] It should be noted that the prescription compositions of Comparative Example 12 and Example 3 are the same, except that the preparation processes are different.

[0110] 2. Preparation process

[0111] The preparation methods of Examples 1-7, Comparative Examples 1-6 and Comparative Examples 9-11 are as follows:

[0112] Step S1, adding polyethylene glycol 3350 to polyethylene glycol 400, heating to 70° C., and stirring until completely dissolved to obtain a molten liquid A;

[0113] Step S2, cooling the molten solution A obtained in step 1 to room temperature, adding polyvinyl pyrrolidone K90, and stirring until uniform to obtain a molten solution B;

[0114] Step S3, adding the melt B into the paste making pot, adding the friction agent, stabilizer, sodium magnesium lithium silicate into the paste making pot, stirring for about 30 minutes under vacuum conditions to obtain a paste;

[0115] Step S4, mix the functional ingredients evenly, add them into the paste, and stir for about 10 minutes;

[0116] Step S5, adding a foaming agent to the paste, and stirring for about 10 minutes under vacuum conditions;

[0117] Step S6: adding essence to the paste, stirring for about 10 minutes under vacuum conditions to obtain toothpaste.

[0118] The preparation method of Comparative Example 7 is similar to the preparation methods of Examples 1-7, Comparative Examples 1-6 and Comparative Examples 9-11, except that in step S1 of Comparative Example 7, carbomer is used instead of polyethylene glycol 400.

[0119] The preparation method of Comparative Example 8 is similar to the preparation methods of Examples 1-7, Comparative Examples 1-6 and Comparative Examples 9-11, except that in Comparative Example 8, polyvinyl pyrrolidone K90 is directly added to polyethylene glycol 400, as follows:

[0120] Step 1, adding polyvinyl pyrrolidone K90 to polyethylene glycol 400, stirring until uniform, to obtain a dispersion;

[0121] Step 2, add the dispersion into the paste making pot, add the friction agent, stabilizer, sodium magnesium lithium silicate into the paste making pot, stir for about 30 minutes under vacuum conditions to obtain a paste;

[0122] Step 3: Mix the active ingredients evenly, add them into the paste, and stir for about 10 minutes;

[0123] Step 4: Add the foaming agent to the paste and stir for about 10 minutes under vacuum conditions;

[0124] Step 5: Add the essence into the paste and stir for about 10 minutes under vacuum conditions to obtain toothpaste.

[0125] The preparation method of Comparative Example 12 is similar to the preparation methods of Examples 1-7, 1-6 and 9-11, except that: in Comparative Example 12, step S1 is omitted, polyethylene glycol 3350 is added together with the friction agent, and polyvinyl pyrrolidone K90 is directly added to polyethylene glycol 400, as follows:

[0126] Step 1, adding polyvinyl pyrrolidone K90 to polyethylene glycol 400, stirring until uniform, to obtain a dispersion;

[0127] Step 2, add the dispersion into the paste making pot, add polyethylene glycol 3350, abrasive, stabilizer, sodium magnesium lithium silicate into the paste making pot, stir for about 30 minutes under vacuum conditions to obtain a paste;

[0128] Step 3: Mix the active ingredients evenly, add them into the paste, and stir for about 10 minutes;

[0129] Step 4: Add the foaming agent to the paste and stir for about 10 minutes under vacuum conditions;

[0130] Step 5: Add the essence into the paste and stir for about 10 minutes under vacuum conditions to obtain toothpaste.

[0131] 2. Performance Test

[0132] 1. Consistency, pH value and stability test

[0133] Test samples: Examples 1-7 and Comparative Examples 1-12;

[0134] Test indicators: pH value, consistency, stability;

[0135] Test method: According to the toothpaste consistency measurement method specified in GB8372-2001, the consistency of the toothpaste in each embodiment and the comparative example was tested; according to the toothpaste pH meter test method specified in GB / T8372-2017, the pH value of the toothpaste in each embodiment and the comparative example was tested;

[0136] Test results: The pH value, consistency and stability test results of the toothpastes in Examples 1-7 measured by the above method are shown in Table 3.

[0137] Table 3

[0138]

[0139] It can be seen from the results in Table 3 that the toothpaste in each example has good stability, suitable consistency and pH value. And from the comparison of the results of Examples 3-5, it can be seen that the dosage ratio of each substance in the functional component affects the pH value of the toothpaste.

[0140] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Examples 1-3 are shown in Table 4.

[0141] Table 4

[0142]

[0143] The difference between Comparative Examples 1-3 and Example 3 is mainly that the setting of the functional components in Comparative Examples 1-3 is different from that in Example 3. By comparing the results of Example 3 and Comparative Examples 1-3, it can be seen that the pH of the toothpaste using sodium percarbonate alone is relatively high, and the pH value of the toothpaste will continue to increase during storage, and the pH value of the toothpaste using potassium persulfate alone is relatively low, and the pH value of the toothpaste will decrease during storage. It shows that the toothpaste prepared by using a compound of percarbonate, persulfate and dihydrogen pyrophosphate as the functional component has a suitable pH value, and the pH value changes little during storage.

[0144] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Example 4 are shown in Table 5.

[0145] Table 5

[0146]

[0147] It should be noted that the toothpaste in Comparative Example 4 that had a short-term flatulence problem could not be continued in the experiment, and the subsequent consistency and pH value could not be tracked.

[0148] The main difference between Comparative Example 4 and Example 3 is that no stabilizer is added in Comparative Example 4. Comparison of the results of Example 3 and Comparative Example 4 shows that the absence of a stabilizer will cause the toothpaste to swell quickly and the functional ingredients to be unstable. This indicates that the stability of the functional ingredients in the toothpaste can be improved by adding a stabilizer.

[0149] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Examples 5-6 are shown in Table 6. The appearance of the toothpaste in Example 3 and Comparative Example 5 is as follows: Figure 1 As shown, Figure 1 The left side is the toothpaste in Comparative Example 5, and the right side is the toothpaste in Example 3; Figure 1 It can be seen that the toothpaste in Comparative Example 5 has flatulence. Figure 2 As shown, Figure 2 The left side is the toothpaste paste in Comparative Example 5, and the right side is the toothpaste paste in Example 3; Figure 2 It can be seen that liquid phase precipitation occurs in the toothpaste in Comparative Example 5.

[0150] Table 6

[0151]

[0152] It should be noted that the toothpastes in Comparative Examples 5-6 that had a short-term flatulence problem could not be continued in the experiment, and the subsequent consistency and pH value could not be tracked.

[0153] The main difference between Comparative Examples 5-6 and Example 3 is that propylene glycol and glycerol are used to replace part of polyethylene glycol 400 in Comparative Examples 5-6. The toothpaste in Comparative Examples 5-6 has flatulence, indicating that the addition of glycerol and propylene glycol as moisturizers will lead to abnormal stability of the toothpaste, and the effective ingredients will be quickly released during storage, resulting in flatulence problems, and liquid phase precipitation will occur in the paste. Using polyethylene glycol 300 and / or 400 as a moisturizer is conducive to further improving the stability of the toothpaste.

[0154] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Examples 7-8 are shown in Table 7.

[0155] Table 7

[0156]

[0157] The main difference between Comparative Examples 7-8 and Example 3 is that polyvinyl pyrrolidone K90 and carbomer are used as thickeners in Comparative Example 7, while only polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate are used as thickeners in Comparative Example 8, and polyethylene glycol 3350 is not used. Comparison of the results of Example 3 and Comparative Examples 7-8 shows that the addition of traditional thickeners such as carbomer will cause liquid phase precipitation problems in toothpaste, and the consistency of toothpaste will increase significantly with storage, affecting the performance of toothpaste; and when the thickener does not contain polyethylene glycol 3350, the consistency of toothpaste will decrease and the stability will be abnormal. It shows that the use of a compound of polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate as a thickener, combined with a specific preparation process, can give toothpaste good stability and solve the problem of easy water separation and too high or too low consistency of toothpaste.

[0158] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Examples 9-11 are shown in Table 8.

[0159] Table 8

[0160]

[0161] It should be noted that the toothpastes in Comparative Examples 9-11 that had a short-term flatulence problem could not be continued in the experiment, and the subsequent consistency and pH value could not be tracked.

[0162] The difference between Comparative Examples 9-11 and Example 3 is mainly that similar inorganic salts are used to replace potassium persulfate or dipotassium dihydrogen pyrophosphate in the functional ingredients in Comparative Examples 9-11. Comparison of the results of Example 3 and Comparative Examples 9-11 shows that the introduction of other similar inorganic salts such as sodium bicarbonate, disodium hydrogen phosphate, potassium persulfate, etc. will cause unstable storage of peroxides and flatulence problems in toothpaste. This shows that the use of percarbonate, persulfate and dihydrogen pyrophosphate as the functional ingredients in this application is conducive to improving the storage stability of percarbonate.

[0163] The pH value, consistency and stability test results of the toothpaste in Example 3 and Comparative Example 12 are shown in Table 9.

[0164] Table 9

[0165]

[0166] The difference between Comparative Example 12 and Example 3 is that Comparative Example 12 adopts a different preparation process, step S1 is omitted in Comparative Example 12, polyethylene glycol 3350 is added together with the abrasive, and polyvinyl pyrrolidone K90 is directly added to polyethylene glycol 400. By comparing the results of Example 3 and Comparative Example 12, it can be seen that under the same formulation conditions, different preparation processes have a greater impact on the stability and consistency of toothpaste.

[0167] 2. Active oxygen retention rate and release rate test

[0168] Refer to the method 16 of GB / T 13173-2021 "Test for active oxygen content in detergents".

[0169] Test samples: Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, Comparative Example 3 and corresponding high temperature 8-week samples;

[0170] Testing instruments: centrifuge, acid burette, measuring cylinder, pipette, Mini10k low-speed centrifuge, etc.

[0171] Test method: Accurately weigh 5g of the test sample, add it to 10g of water, stir it quickly with a glass rod to dissolve, take the solution once for 30s, 2min, 5min, and 10min, take 1.5mL each time, centrifuge it at 5000r / min for 1min, take the supernatant and add it to a conical flask, and make up to 100ml. Add 50mL of 2.5mol / L sulfuric acid solution, use 0.02mol / L potassium permanganate standard titrant, and titrate to a light pink color, which does not fade for at least 15s.

[0172] Test results: The test results of active oxygen content at different dissolution times of the embodiments and comparative examples are shown in Table 10.

[0173] Table 10

[0174]

[0175] From the comparison of the results of Examples 2-4 and Comparative Examples 1-3 in Table 10, it can be seen that if only potassium persulfate is included in the functional ingredients, the active oxygen content is almost undetectable; active oxygen can be detected when sodium percarbonate is added to the functional ingredients. From the comparison of the results of Examples 2-4, it can be seen that increasing the amount of potassium persulfate, dipotassium dihydrogen pyrophosphate and sodium percarbonate can increase the release rate of active oxygen; comparing the test results of room temperature samples and high temperature samples, it can be seen that after eight weeks at 45°C, the active oxygen content of the formula with sodium percarbonate added has a certain attenuation, but the attenuation ratio is controllable.

[0176] From the comparison of the results of Example 3 and Comparative Example 1, it can be seen that when the total amount of percarbonate and persulfate added is the same, the release rate of active oxygen can be significantly increased by compounding percarbonate, persulfate and dihydrogen pyrophosphate. It shows that the use of percarbonate, persulfate and dihydrogen pyrophosphate as a functional ingredient can effectively increase the release rate of active oxygen during use, and can also improve the storage stability of peroxide.

[0177] Although the test results of active oxygen retention rate and release rate of other embodiments are not given herein, it should be noted that other embodiments have similar or close results to Embodiments 2-4.

[0178] 3. Simulate the pH change rate during use

[0179] Test samples: Example 3, Comparative Example 1, Comparative Example 2, Comparative Example 3;

[0180] Testing instruments: pH meter, electronic balance, magnetic stirrer, etc.

[0181] Test method: Accurately weigh 5g of the test sample into a glass cup, put it into a rotor, add 20g of deionized water, put in the pH meter probe, turn on the magnetic stirrer, measure the real-time pH value every 30s, and measure for a total of 3 minutes to simulate a three-minute brushing process. The test results are shown in Table 11.

[0182] Table 11

[0183]

[0184] From the comparison of the results of Example 1 and Comparative Examples 1-3, it can be seen that when only sodium percarbonate is used as the effective ingredient, the pH value will rise rapidly during the brushing process; when sodium percarbonate and potassium persulfate are used as the effective ingredients, the pH value rises faster during the brushing process, and the problem of repeated pH values ​​will occur during use; when potassium persulfate is used alone as the effective ingredient, the pH of the toothpaste is acidic; when sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate are used as the effective ingredients, the pH value of the toothpaste rises slowly and is maintained within an appropriate range, the toothpaste is gentler during use, and the problem of high irritation to the oral mucosa during the use of peroxide toothpaste is effectively alleviated.

[0185] Although the test results of the pH value change rate during use of other embodiments are not given herein, it should be noted that other embodiments have similar or close results to Example 3.

[0186] 4. Stain removal effect test

[0187] Test samples: Example 2, Example 3, Example 4, Comparative Example 1, Comparative Example 2, Comparative Example 3;

[0188] Testing instruments: electric toothbrush, colorimeter, dyeing machine, electronic balance, etc.

[0189] Test method: Use 30 tea bags, soak them in 1000mL boiling water, seal the beaker mouth with plastic wrap, and keep the temperature between 70~90℃ and soak for 30 minutes. After 30 minutes, take out the tea bags and add 15g instant coffee, stir for 5 minutes to completely dissolve it, and then continue to seal the beaker mouth with plastic wrap. When the solution cools down to below 37℃, add 0.16g ferric chloride hexahydrate and 3.75g mucin, stir until completely dissolved, and then add 500mL TSB staining medium containing Sarcina lutea. Use a grinding and polishing machine to grind the cattle bone slices to the specifications of the brush slot size of the test brush machine, fix the polished sheet on the dyeing machine wheel, soak in the dyeing solution for 24 hours, take out the sheet, rinse the surface with tap water, and blow dry with cold air or dry at room temperature for use. Select sheets with uniform stain distribution and L values ​​between 60 and 75, and try to ensure that the initial values ​​are close. Accurately weigh 2g of toothpaste and place it on the dyed cow bone slices. Add 2ml of water with a dropper. Use an electric toothbrush with the same vibration frequency to brush the cow bone slices for 3 minutes. Rinse with clean water three times. After cooling, measure the L value of the cow bone slices. Then put them in artificial saliva and let them stand for 24 hours. Repeat the above operation twice. Record the L value after each brushing. The test results are shown in Table 12.

[0190] Table 12

[0191]

[0192] From the comparison between Examples 2-4 and Comparative Examples 1-3, it can be seen that the toothpaste in Examples 2-4 has good stain removal and whitening effects on teeth, and its effect is much better than that of Comparative Examples 1-3. Comparing the results of brushing once, it can be seen that only the toothpaste in Comparative Example 2 has a certain stain removal effect, and the whiteness of other test samples has decreased to a certain extent compared with the initial value. After analysis, it is believed that the active oxygen may have an oxidative effect on tea stains and coffee stains while removing stains, which deepens the color of the test samples. With the increase in the number of brushing times, after the second brushing, the advantages of the test samples with higher active oxygen content gradually become more prominent.

[0193] Although the stain removal effect test results of other embodiments are not given herein, it should be noted that other embodiments have similar or close results to Embodiments 2-4.

[0194] In summary, in the composition provided by the present application, percarbonate, persulfate and dihydrogen pyrophosphate are used as functional ingredients, which can effectively increase the release rate of hydrogen peroxide during use, and reduce the pH value during use, while protecting the oral mucosa while exerting its stain removal and whitening effect to the greatest extent; and the storage stability of peroxide can also be improved. Polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate are used as thickeners to give the toothpaste formula good stability, solving the problem of easy water separation, too high or too low consistency of toothpaste. Using two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate as stabilizers can improve the stability of the functional ingredients in the formula, thereby improving the retention rate of active oxygen content. The toothpaste containing the composition has excellent stain removal and whitening effects, and the problems of water discharge and paste ene at the toothpaste tube mouth are effectively alleviated, while reducing the pH value during use and reducing the irritation to the oral mucosa.

[0195] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0196] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A composition, characterized in that The invention comprises functional ingredients, a thickener and a stabilizer, wherein the functional ingredients comprise percarbonate, persulfate and dihydrogen pyrophosphate, the thickener comprises polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate, and the stabilizer comprises two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

2. The composition according to claim 1, characterized in that The mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.3-1), and can be (2-6):(0.5-0.7):(0.3-1); and / or The mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the functional ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5); and / or The effective ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

3. The composition according to claim 1, characterized in that The mass ratio of the functional ingredient, the thickener and the stabilizer is (0.6-4.5):(3-7):(0.2-3).

4. Use of the composition according to any one of claims 1 to 3 in the preparation of toothpaste.

5. A toothpaste, characterized in that: The toothpaste comprises a composition, which comprises functional ingredients, a thickener and a stabilizer, wherein the functional ingredients comprise percarbonate, persulfate and dihydrogen pyrophosphate, the thickener comprises polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate, and the stabilizer comprises two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate.

6. The toothpaste according to claim 5, characterized in that The mass ratio of polyethylene glycol 3350, sodium magnesium lithium silicate and polyvinyl pyrrolidone K90 in the thickener is (2-6):(0.3-0.8):(0.3-1), and can be optionally (2-6):(0.5-0.7):(0.3-1).

7. The toothpaste according to claim 5, characterized in that The mass ratio of percarbonate, persulfate and dihydrogen pyrophosphate in the functional ingredients is (0.4-1.5):(0.1-0.5):(0.1-2.5); and / or The effective ingredients include sodium percarbonate, potassium persulfate and dipotassium dihydrogen pyrophosphate.

8. The toothpaste according to any one of claims 5 to 7, characterized in that The toothpaste also includes a moisturizer, an abrasive, a foaming agent and a flavor; Optionally, the toothpaste comprises, by weight: 0.6 to 4.5 parts of the functional ingredient, 3 to 7 parts of the thickener, 0.2 to 3 parts of the stabilizer, 34 to 50 parts of the moisturizer, 40 to 55 parts of the friction agent, 1.5 to 2 parts of the foaming agent and 0.5 to 1 part of the fragrance.

9. The toothpaste according to claim 8, characterized in that The moisturizing agent includes one or more of polyethylene glycol 300 and polyethylene glycol 400; Optionally, the humectant excludes glycerin, propylene glycol and sorbitol.

10. The toothpaste according to claim 8, characterized in that The abrasive comprises one or more of the group consisting of calcium pyrophosphate and calcium carbonate; and / or The foaming agent includes one or more of sodium lauryl sulfate, cocamidopropyl betaine and sodium methyl cocoyl taurate; and / or The flavor includes any one of peppermint flavor, spearmint flavor and wintergreen flavor.

11. The toothpaste according to any one of claims 5-7 and 9-10, characterized in that The toothpaste is anhydrous toothpaste.

12. A method for preparing toothpaste, characterized in that: The toothpaste comprises functional ingredients, a thickener, a stabilizer, a moisturizer, an abrasive, a foaming agent and a flavor; the functional ingredients comprise percarbonate, persulfate and dihydrogen pyrophosphate; the stabilizer comprises two or more of sodium sulfate, sodium carbonate, sodium silicate and pentasodium tripolyphosphate; the thickener comprises polyethylene glycol 3350, polyvinyl pyrrolidone K90 and sodium magnesium lithium silicate; the preparation method comprises the following steps: preparing a melt A comprising polyethylene glycol 3350 and the humectant; The cooled molten liquid A is mixed with polyvinyl pyrrolidone K90 to prepare a molten liquid B; The melt B, the friction agent, the stabilizer and sodium magnesium lithium silicate are mixed to prepare a paste; The functional ingredients, the foaming agent and the flavor are sequentially added into the paste to prepare the toothpaste.

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