Traditional Chinese medicine composition, sunscreen cream as well as preparation method and application of sunscreen cream

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to a traditional Chinese medicine composition, a sunscreen cream and a preparation method and application of the sunscreen cream, and the traditional Chinese medicine composition is selected from any one of the following compositions: (a) a radix scutellariae extracting solution, a rhizoma coptidis extracting solution, a flos sophorae immaturus extracting solution and a rhizoma curcumae longae extracting solution; (b) a radix scutellariae extracting solution, a fructus evodiae extracting solution, a flos sophorae immaturus extracting solution and a rhizoma curcumae longae extracting solution; and (c) a fructus evodiae extracting solution, a rhizoma coptidis extracting solution, a flos sophorae immaturus extracting solution and a rhizoma curcumae longae extracting solution. The sunscreen cream prepared on the basis of the traditional Chinese medicine composition is mild, has no irritation effect on skin, has a relatively strong ultraviolet absorption effect in a UVA region or a UVB region, is natural sunscreen cream with broad-spectrum absorption property, and has excellent low-temperature stability and thermal stability.

Description

Technical Field

[0001] The invention belongs to the technical field of skin care products, and specifically relates to a traditional Chinese medicine composition, a sunscreen, and a preparation method and application thereof. Background Art

[0002] As an important cosmetic ingredient that protects the skin from UV damage, sunscreen has always been a hot topic of research. At present, sunscreen products on the market are mainly divided into two categories: chemical sunscreen and physical sunscreen. Chemical sunscreen mainly absorbs ultraviolet rays and converts them into heat energy for release, while physical sunscreen achieves the sunscreen effect by reflecting and scattering ultraviolet rays. However, chemical sunscreens may cause skin irritation and allergies during use, and may also cause pollution such as coral death; physical sunscreens are relatively safe, but the titanium dioxide and zinc oxide particles in them may clog pores and affect the breathability of the skin, causing skin problems such as dermatitis. Natural plant sunscreens are safe and environmentally friendly, and can well avoid the above problems.

[0003] Natural plant sunscreens have become the focus of research in recent years because of their natural, safe and environmentally friendly characteristics. The active ingredients of natural plant sunscreens are often derived from specific plant extracts, which are usually rich in antioxidants, vitamins and other ingredients that are beneficial to skin health. For example, baicalin in Scutellaria baicalensis, antioxidants and anti-inflammatory ingredients in Saussurea involucrata, and curcumin in turmeric are all known natural compounds with strong anti-inflammatory and antioxidant effects. These plant extracts can not only protect the skin from UV damage, but also provide other skin care benefits, such as moisturizing and repairing damaged skin.

[0004] The present invention aims to use Chinese herbal medicine extracts as the main raw materials to study the preparation of composite natural sunscreens and their application in cosmetics. Through the screening and compounding of a variety of natural plant extracts, a multifunctional composite natural sunscreen with full-band high absorption, safety and high efficiency is prepared with scientific formula design and preparation technology. Summary of the invention

[0005] The invention develops a Chinese medicine composition for sun protection and a sunscreen prepared therefrom. The sunscreen is based on Chinese medicine components, has excellent safety, does not irritate the skin, and has excellent sun protection effect and stability.

[0006] In order to achieve the above object, the present invention can adopt the following technical solutions:

[0007] On the one hand, the present invention provides a traditional Chinese medicine composition, which is selected from any one of the following compositions: (a) scutellaria baicalensis extract, coptis chinensis extract, sophora japonica seed extract and turmeric extract; (b) scutellaria baicalensis extract, evodia rutaecarpa extract, sophora japonica seed extract and turmeric extract; (c) evodia rutaecarpa extract, coptis chinensis extract, sophora japonica seed extract and turmeric extract.

[0008] Preferably, in the above-mentioned traditional Chinese medicine composition, the volume ratio of Scutellaria baicalensis extract, Coptis chinensis extract, Sophora japonica seed extract and Curcuma longa extract is 2:3:2:3; the volume ratio of Scutellaria baicalensis extract, Evodia rutaecarpa extract, Sophora japonica seed extract and Curcuma longa extract is 1:2:1:2; the volume ratio of Evodia rutaecarpa extract, Coptis chinensis extract, Sophora japonica seed extract and Curcuma longa extract is 1:2:1:2.

[0009] Preferably, the preparation method of the above-mentioned Chinese medicine extract comprises: drying the Chinese medicine raw material, crushing it to obtain Chinese medicine powder, mixing the Chinese medicine powder with ethanol, heating and soaking, ultrasonic extraction, and filtering to obtain a filtrate, namely the Chinese medicine extract.

[0010] Preferably, the preparation method of the scutellaria baicalensis extract comprises: drying scutellaria baicalensis, crushing to obtain scutellaria baicalensis powder, soaking the scutellaria baicalensis powder in 75% ethanol by mass, heating, ultrasonic extraction at 60°C for 60 minutes, and filtering to obtain a filtrate, namely the scutellaria baicalensis extract; the preparation method of the coptis chinensis extract comprises: drying coptis chinensis, crushing to obtain coptis chinensis powder, soaking the coptis chinensis powder in 75% ethanol by mass, heating, ultrasonic extraction at 50°C for 60 minutes, and filtering to obtain a filtrate, namely the coptis chinensis extract; the preparation method of the evodia rutaecarpa extract comprises: drying evodia rutaecarpa, crushing to obtain evodia rutaecarpa powder, and evodia rutaecarpa powder The method comprises the following steps: soaking the mixture in 50% ethanol by mass, heating the mixture, ultrasonically extracting the mixture at 60°C for 60 minutes, and filtering the mixture to obtain a filtrate, namely, the evodia rutaecarpa extract; the method for preparing the above-mentioned sophora japonica extract comprises the following steps: drying the scutellaria baicalensis, crushing the mixture to obtain sophora japonica powder, soaking the sophora japonica powder in 50% ethanol by mass, heating the mixture, ultrasonically extracting the mixture at 50°C for 50 minutes, and filtering the mixture to obtain a filtrate, namely, the sophora japonica extract; the method for preparing the above-mentioned turmeric extract comprises the following steps: drying the turmeric, crushing the mixture to obtain turmeric powder, soaking the turmeric powder in 75% ethanol by mass, heating the mixture, ultrasonically extracting the mixture at 50°C for 50 minutes, and filtering the mixture to obtain a filtrate, namely, the turmeric extract.

[0011] On the other hand, the present invention provides a sunscreen, which consists of an oil phase and a water phase, wherein the oil phase comprises white vaseline, lanolin, hexadecanol, stearic acid, Tween-80 and glyceryl monostearate; and the water phase comprises glycerin, methyl parahydroxybenzoate, sodium copper ethylenediaminetetraacetate, the Chinese medicine composition of the present invention and the balance water.

[0012] Preferably, the mass fraction of the above-mentioned traditional Chinese medicine composition in the sunscreen is 2.5%-3.5%.

[0013] Preferably, in the above-mentioned sunscreen, the mass fractions of vaseline, lanolin, cetyl alcohol, stearic acid, Tween-80, glyceryl monostearate, glycerin, methyl paraben, sodium copper ethylenediaminetetraacetate, Chinese medicine composition and water in the sunscreen are 0.5%, 0.5%, 3%, 3.5%, 1.2%, 0.15%, 5%, 0.15%, 0.05%, 2.5%-3.5% and the balance is water, respectively.

[0014] In another aspect, the present invention provides a method for preparing the sunscreen of the present invention, comprising: (1) dissolving raw materials in an oil phase to obtain a first solution; (2) mixing glycerin, methyl paraben, sodium copper ethylenediaminetetraacetate and water in an aqueous phase, heating and adding the Chinese medicine composition of the present invention to obtain a second solution; (3) slowly adding the second solution to the first solution, stirring and emulsifying the solution to obtain the sunscreen.

[0015] Preferably, in the above preparation method, the temperature for stirring and emulsifying is 80°C.

[0016] Preferably, in the above preparation method, the stirring and emulsification time is 30 minutes.

[0017] The beneficial effects of the present invention include at least:

[0018] (1) The sunscreen prepared based on the Chinese medicine composition of the present invention is mild and has no irritating effect on the skin.

[0019] (2) The sunscreen prepared based on the Chinese medicine composition of the present invention has a strong ultraviolet absorption effect in both the UVA region and the UVB region, and is a natural sunscreen with a broad-spectrum absorption property.

[0020] (3) The sunscreen prepared based on the Chinese medicine composition of the present invention has excellent low-temperature stability and thermal stability. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The effect of solvent concentration on the extraction of Chinese herbal medicines;

[0022] Figure 2 The effect of extraction time on the extraction of Chinese herbal medicines;

[0023] Figure 3 The effect of extraction temperature on the extraction of Chinese herbal medicines;

[0024] Figure 4 It is a concentrated Chinese herbal medicine extract;

[0025] Figure 5 is the absorbance of different compound ratios;

[0026] Figure 6 For sunscreens with different formulations;

[0027] Figure 7 It is a sunscreen after high temperature and centrifugation;

[0028] Figure 8 It is a sunscreen after low temperature and centrifugation;

[0029] Fig. 9 The UV absorption spectra of each sunscreen are shown in Figure 2. DETAILED DESCRIPTION

[0030] The examples are provided to better illustrate the present invention, but the present invention is not limited to the examples. Therefore, those skilled in the art may make non-essential improvements and adjustments to the implementation scheme according to the above invention content, which still fall within the protection scope of the present invention.

[0031] The terms used herein are only used to describe specific embodiments and are not intended to limit the present disclosure. Unless the context has a significantly different meaning, expressions in the singular include expressions in the plural. As used herein, it should be understood that terms such as "include", "have", "comprise" and the like are intended to indicate the presence of features, numbers, operations, components, parts, elements, materials or combinations. The terms of the present invention are disclosed in the specification, and are not intended to exclude the possibility that one or more other features, numbers, operations, components, parts, elements, materials or combinations thereof may exist or may be added. As used herein, " / " may be interpreted as "and" or "or", depending on the circumstances.

[0032] In order to better understand the present invention, the content of the present invention is further explained below in conjunction with specific examples, but the content of the present invention is not limited to the following examples.

[0033] 1. Screening of single Chinese herbal medicine extracts

[0034] (I) Preparation of Chinese medicine extracts

[0035] Each Chinese herbal medicine (chrysanthemum, evodia rutaecarpa, coptis root, sophora japonica seed, turmeric, safflower, scutellaria baicalensis, rhubarb, clove leaf, licorice, senna leaf, kudzu root, rhodiola rosea, knotweed, honeysuckle, kudingcha, aloe gel, Panax notoginseng, all purchased from Nanjing Tongrentang) was placed in a drying oven at 50°C for one night, and then crushed with a grinder after complete drying, and sieved to obtain Chinese herbal medicine powder; 1.0g of Chinese herbal medicine powder was weighed and placed in a 100mL test tube, and 50mL of 50% ethanol solution was added, and soaked in a water bath at 50 degrees Celsius for 60min, and then an ultrasonic cleaning machine was used to set the temperature to 50°C, the extraction frequency to 45KHz, and the extraction time to 60 minutes. After the extraction was completed, it was filtered, the filter residue was discarded, and 1mL of the filtrate was taken in a 50mL volumetric flask to 50mL to obtain different Chinese herbal medicine extracts.

[0036] (II) Determination of sunscreen ability of traditional Chinese medicine

[0037] The above 18 diluted Chinese herbal medicine extracts were measured by ultraviolet spectrophotometer for their respective ultraviolet absorption spectra at 280nm-400nm, with a 50% concentration of ethanol solution as a reference. Three average absorbance values ​​were calculated according to the following formula: (1) total average absorbance value; (2) average absorbance value at 280nm-320nm (UVB region); (3) average absorbance value at 320nm-400nm (UVA region). Based on the ultraviolet spectra measured by the diluted extracts, the three absorbance values ​​of each Chinese herbal medicine extract were compared and screened, and several plant extracts with larger average absorbance and larger coverage area were selected.

[0038] Total average absorbance:

[0039] Average absorbance in UVB region:

[0040] Average absorbance in UVA region:

[0041] According to the obtained UV absorption spectra of 18 kinds of Chinese herbal medicines, a UV absorbance value was taken every 10nm at a wavelength of 280nm to 400nm as the average value of UV absorption in this band, and the average absorbance in the UVB region and UVA region was calculated respectively. The herbs were sorted according to the UVA absorbance. The results are shown in Table 1.

[0042] Table 1 Average absorbance of Chinese herbal medicine extracts

[0043] type UVB average absorbance UVA average absorbance Coptis chinensis 4.900 4.175 Evodia rutaecarpa 5.200 3.338 Scutellaria baicalensis 5.160 2.525 safflower 3.640 3.663 Chrysanthemum 4.480 2.375 Sophora japonica 3.160 3.600 Kudingcha 4.280 2.188 Aloe Vera 3.140 2.525 Knotweed 4.100 1.325 rhubarb 3.660 1.313 turmeric 1.500 3.075 Pueraria root 3.720 0.825 honeysuckle 2.740 1.575 Rhodiola rosea 3.180 0.713 Senna 1.680 1.375 clove 1.600 1.050 Licorice 1.280 0.763 Panax notoginseng 0.600 0.450

[0044] According to the absorbance measurement results, the Chinese herbal medicine extracts with strong absorption in the UVB region include: Evodia rutaecarpa, Scutellaria baicalensis, Coptis chinensis, Chrysanthemum officinale, Kudingcha, Polygonum cuspidatum, Pueraria lobata and other 12 Chinese herbal medicines; the Chinese herbal medicines with strong absorption in the UVA region include: Coptis chinensis, Carthamus tinctorius, Sophora japonica, Evodia rutaecarpa, Curcuma longa and other 9 Chinese herbal medicines. Based on the principle of compounding an extract with broad-spectrum absorption, four plants with strong absorption in the UVB region were selected: Evodia rutaecarpa (strong absorption at 280nm~360nm), Scutellaria baicalensis (strong absorption at 280nm~330nm), Coptis chinensis (strong absorption at 280nm~360nm), Fetal chrysanthemum (strong absorption at 280nm ~ 350nm wavelength); two plants with strong absorption in the UVA area: Sophora japonica (strong absorption at 280nm ~ 380nm wavelength) and turmeric (strong absorption at 370nm ~ 400nm wavelength); by compounding 6 kinds of Chinese herbal medicine extracts, a natural ultraviolet absorber with high efficiency absorption in the entire band of 280nm ~ 400nm can be obtained; at the same time, it was found that safflower extract has broad-spectrum absorption properties, and its ultraviolet absorption spectrum is very close to a straight line, which is an ideal natural broad-spectrum ultraviolet absorber, so safflower was selected as the control of the compound extract.

[0045] 2. Single factor experiment of acoustic wave extraction method

[0046] (I) Determination of optimal extraction concentration

[0047] Weigh 5 portions of 0.5g of the above 6 kinds of Chinese medicine powder (sophora japonica, turmeric, scutellaria, fetal chrysanthemum, evodia rutaecarpa, coptis chinensis) respectively, extract for 40 minutes at 40℃ and 45KHz with 50mL of pure water, 25%, 50%, 75%, and 100% ethanol solution respectively; filter and collect the filtrate, dilute to 50mL (each mL is equivalent to 10mg of crude drug), take 1mL of the dilute solution to 25mL volumetric flask and dilute to 25mL (each mL is equivalent to 4mg of crude drug). Take the prepared solution with the solvent of each concentration as reference, and measure the ultraviolet absorption spectrum of each at 280nm~400nm. The optimal extraction concentration is obtained by comparing the ultraviolet absorbance under each condition.

[0048] like Figure 1 As shown in the figure, with the increase of extraction concentration, the average absorbance of the extract first increases and then decreases. Therefore, the optimal extraction concentration of Evodia rutaecarpa, Sophora japonica, and Carthamus tinctorius is 50% ethanol; the optimal extraction concentration of Coptis chinensis, Curcuma longa, Chrysanthemum morifolium, and Scutellaria baicalensis is 75% ethanol. Various Chinese herbal extracts contain both polar and non-polar products. The extraction rate of pure water or pure alcohol is low. A certain concentration of ethanol solution can extract polar and non-polar products at the same time, and the extraction rate is higher.

[0049] (II) Determination of the optimal extraction time

[0050] Take the ethanol of the best extraction concentration determined above as solvent, weigh 5 portions of 0.5g of the above 6 kinds of Chinese medicine powder, add 50mL of ethanol solution, and use ultrasonic extraction method to extract for 30min, 40min, 50min, 60min, and 70min respectively at 40℃ and 45KHz. Filter and collect the filtrate, dilute to 50mL (each milliliter is equivalent to 10mg of crude drug), take 1mL of the dilute solution to 25mL volumetric flask and dilute to 25mL (each milliliter is equivalent to 4mg of crude drug). Take the prepared solution with the solvent of each concentration as reference, and measure its ultraviolet absorption spectrum at 280-400nm. The best extraction time is obtained by comparing the ultraviolet absorbance under each condition.

[0051] like Figure 2 As shown in the figure, the absorbance of the extract increases first and then decreases with the extraction time. Under the current experimental conditions, the optimal extraction time for safflower, sophora japonica, and turmeric is 50 minutes, the optimal extraction time for coptis root, evodia rutaecarpa, and scutellaria baicalensis is 60 minutes, and the optimal extraction time for chrysanthemum is 70 minutes. It may be due to the different stability of the products with ultraviolet absorption. If the extraction time is too long, it will lose its activity or decompose. The longer the extraction time, the better. Instead, there should be a specific and scientifically reasonable time control.

[0052] (III) Determination of the optimal extraction temperature

[0053] Under the conditions of the best extraction concentration and best extraction time of the six Chinese herbal medicine raw materials, weigh five portions of 0.5g of each of the six Chinese herbal medicine powders, add 50mL of ethanol solution, and use ultrasonic extraction method to extract at 40℃, 50℃, 60℃, and 70℃ respectively. Filter and collect the filtrate, dilute to 50mL (each milliliter is equivalent to 10mg of crude drug), take 1mL of the dilute solution to a 25mL volumetric flask and dilute to 25mL (each milliliter is equivalent to 4mg of crude drug). The prepared solution is measured with reference to the solvent of each concentration, and its ultraviolet absorption spectrum at 280nm to 400nm is measured. The optimal extraction temperature is obtained by comparing the ultraviolet absorbance under each condition.

[0054] like Figure 3 As shown, the optimal extraction temperature for Evodia rutaecarpa, Chrysanthemum morifolium, Scutellaria baicalensis and Carthamus tinctorius is 60℃, the optimal extraction temperature for Sophora japonica seed and Curcuma longa is 50℃, and the optimal extraction temperature for Coptis chinensis is 50℃.

[0055] 3. Screening of compound ratio of Chinese herbal medicine extracts

[0056] (I) Preparation of Chinese medicine extracts

[0057] Weigh 15.0 g each of Scutellaria baicalensis, chrysanthemum, Evodia rutaecarpa, Coptis chinensis, Sophora japonica, Curcuma longa, and Carthamus tinctorius, and extract them at 45 kHz ultrasonic frequency using an ultrasonic cleaner under their respective optimal extraction conditions. After filtration and concentration, 50 mL of each extract was obtained. Each extract was as follows: Figure 4 shown.

[0058] (II) Compounding of Chinese herbal medicine extracts

[0059] Based on the principle of obtaining the best ratio covering the entire band absorption, four Chinese herbal medicines with strong UVB absorption, namely, scutellaria baicalensis, chrysanthemum, evodia rutaecarpa, and coptis chinensis, were combined in pairs, resulting in a total of 6 combinations. Since the absorption curves of chrysanthemum and evodia rutaecarpa in the UVB region were highly overlapped, this combination was discarded (since the absorption rate of safflower extract in the entire band was relatively high and the ultraviolet absorption curve was very close to a straight line, it was an ideal broad-spectrum ultraviolet absorber, so safflower extract was used as a control throughout the process). The remaining 5 combinations were matched with two Chinese herbal medicines with strong UVA absorption, namely, sophora japonica seed and turmeric, to obtain the following 5 compound combinations: (1) scutellaria baicalensis: chrysanthemum: sophora japonica seed: turmeric; (2) scutellaria baicalensis: evodia rutaecarpa: sophora japonica seed: turmeric; (3) scutellaria baicalensis: coptis chinensis: sophora japonica seed: turmeric; (4) chrysanthemum baicalensis: coptis chinensis: sophora japonica seed: turmeric; (5) evodia rutaecarpa: coptis chinensis: sophora japonica seed: turmeric.

[0060] The following 6 compounding ratios (volume ratios) were set: (1) 1:2:2:1; (2) 2:2:3:3; (3) 2:3:2:3; (4) 1:1:2:2; (5) 2:2:3:4; (6) 1:1:1:2; 1 mL of the obtained plant extract was taken, and the volume was made up to 50 mL with a solvent of corresponding concentration, and then 5 compounding combinations were used according to 6 volume ratios, and then the ultraviolet absorption spectra of all the compounding solutions at 280 nm to 400 nm were measured, and the average absorbance in the UVA and UVB regions and the total average absorbance were calculated respectively, so as to obtain the best ratio that can cover the full-band absorption and has a relatively high absorbance.

[0061] The results are as follows Figure 5 As shown in the figure, through the analysis of absorbance, three formulas with better absorption in the whole band were obtained: (1) Scutellaria baicalensis: Coptis chinensis: Sophora japonica seed: Curcuma longa = 2:3:2:3 (Formula 1); (2) Scutellaria baicalensis: Evodia rutaecarpa: Sophora japonica seed: Curcuma longa = 1:2:1:2 (Formula 2); (3) Evodia rutaecarpa: Coptis chinensis: Sophora japonica seed: Curcuma longa = 1:2:1:2 (Formula 3).

[0062] 4. Single factor determination of sunscreen prepared by emulsification

[0063] (1) Sunscreen base formula

[0064] In the example of the present invention, the matrix formula of the sunscreen is shown in Table 2.

[0065] Table 2 Matrix formula of sunscreen

[0066] Element Mass percentage (%) Phase A (Oil Phase) / White Vaseline 0.5 Lanolin 0.5 Cetyl Alcohol 3.0 Stearic acid 3.5 Twain-80 1.2 Glyceryl Monostearate 0.15 Phase B (water phase) / glycerin 5.0 Methylparaben 0.15 Sodium Copper Ethylenediaminetetraacetate 0.05 Chinese herbal medicine extract 3.0 Wahaha purified water Residual water

[0067] (II) Determination of optimal emulsification temperature

[0068] Based on the total amount of 200g, weigh the phase A and phase B drugs respectively, add safflower extract to phase B, and use a magnetic stirrer to emulsify for 30 minutes at 70℃, 75℃, 80℃, 85℃ and 90℃, and observe the emulsification effect at each emulsification temperature; the results show that when the emulsification temperature is 70℃, the emulsion is uneven and has more particles, and the emulsification is incomplete; when the emulsification temperature is 75℃, the emulsion is uniform, but has a small amount of particles, and the emulsification effect is poor; when the emulsification temperature is 80℃, 85℃, and 90℃, the emulsion is uniform and delicate, and the emulsification effect is good; in addition, the thermal stability of Chinese medicine extracts is poor, and too high emulsification temperature can easily inactivate them. The emulsification temperature should be as low as possible, but the emulsification effect is poor if the temperature is too low, so the optimal emulsification temperature is 80℃.

[0069] (III) Determination of optimal emulsification time

[0070] Based on the total amount of 200g, weigh the phase A and phase B drugs respectively, add safflower extract into phase B, and use a magnetic stirrer to emulsify for 20min, 30min, 40min and 50min respectively. The emulsification temperature is 80℃, and the emulsification effect at different emulsification times is observed to obtain the optimal emulsification time. The results show that when the emulsification time is 20min, the emulsification effect is poor, and oil-water separation occurs after standing. When the emulsification time is 30min, 40min and 50min, the emulsion is uniform and fine, without particles, and the emulsification effect is better. In addition, in order to avoid the inactivation of the effective ingredients in the extract at high temperature, the emulsification time should be reduced as much as possible, so the optimal emulsification time should be 30min.

[0071] 5. Preparation of Sunscreen

[0072] From the above, it can be known that the three best compound ratios for ultraviolet absorption are: (1) Scutellaria baicalensis: Coptis chinensis: Sophora japonica seed: Curcuma longa = 2:3:2:3 (Formula 1); (2) Scutellaria baicalensis: Evodia rutaecarpa: Sophora japonica seed: Curcuma longa = 1:2:1:2 (Formula 2); (3) Evodia rutaecarpa: Coptis chinensis: Sophora japonica seed: Curcuma longa = 1:2:1:2 (Formula 3); The three Chinese medicine extracts with different ratios are prepared according to the volume ratio for use; the safflower extract is used as a control, and the four Chinese medicine extracts are used as ultraviolet absorbers respectively, and are emulsified to prepare sunscreens according to the following steps:

[0073] Based on a total amount of 200g, weigh the phase A and phase B drugs respectively, put the phase A drugs into a 250mL beaker, use a magnetic stirrer in a constant temperature water bath at 80℃ until phase A is completely dissolved and stir continuously. After phase A is completely dissolved, keep warm for 10 minutes and keep stirring continuously. Except for the Chinese herbal extract, fully mix the remaining ingredients of phase B, heat to 80℃ in a constant temperature water bath at 80℃ and keep warm for 10 minutes, then add the Chinese herbal extract and mix thoroughly, then immediately pour the mixed phase B slowly into the phase A in the magnetic stirrer and stir continuously, continue stirring for 30 minutes to make it completely emulsified, then remove the beaker from the magnetic stirrer and stir continuously, stop stirring when the emulsion cools to about 40℃, and naturally cool to room temperature to obtain the obtained product.

[0074] 6. Testing of Sunscreen

[0075] 1. Quality testing of sunscreen

[0076] (1) Basic properties

[0077] ①Appearance

[0078] The four different Chinese herbal sunscreens prepared were all light yellow pastes (see Figure 6 ), the paste is uniform and fine without particles; it is easy to apply, skin-friendly, non-sticky and easy to rinse after application.

[0079] ② Determination of pH value

[0080] Take 2.5 g of each of the four sunscreen formulas and the commercially available sunscreen, add 50 mL of Wahaha purified water respectively, stir to mix thoroughly, boil until slightly boiling, cool to room temperature, filter, and use a pH meter to measure the pH value respectively. The measurements were taken three times and the average value was taken. The results are shown in Table 3. The pH values ​​of the five sunscreens are close to the normal pH value of the skin (4.5-5.5), which are relatively mild to the skin.

[0081] Table 3 pH values ​​of different sunscreens

[0082] formula pH Safflower control 5.75 Commercially available control 5.42 Recipe 1 6.62 Recipe 2 6.05 Recipe 3 5.88

[0083] (2) High temperature stability test

[0084] Take an appropriate amount of the 4 kinds of sunscreen lotions obtained (with safflower sunscreen as control 1, and the commercially available sunscreen - Maxine facial sunscreen as control 2), add them into a 15mL centrifuge tube, use the commercially available sunscreen as a control, place them in a 45℃ constant temperature water bath, take them out after 24 hours of constant temperature water bath and naturally cool to room temperature; then use a high-speed centrifuge to centrifuge at a speed of 10000r / min for 20 minutes, then take them out and observe whether the emulsion is uniform and whether there is any precipitation and stratification.

[0085] like Figure 7As shown, the five sunscreen creams are still uniform, without precipitation, stratification, oil-water separation, etc., and have good thermal stability.

[0086] (3) Low temperature stability test

[0087] Take an appropriate amount of the 4 kinds of sunscreen lotions obtained (with safflower sunscreen as control 1, and the commercially available sunscreen - Maxine facial sunscreen), add them into a 15mL centrifuge tube, use the commercially available sunscreen as a control, place in a -18℃ (±2℃) refrigerator, refrigerate for 24 hours, then take out and naturally return to room temperature; then use a high-speed centrifuge to centrifuge at a speed of 10000r / min for 20 minutes, take out and observe whether the emulsion is uniform, and whether there is precipitation and stratification.

[0088] like Figure 8 As shown in the figure, the pastes of the four natural sunscreens were still uniform, without any precipitation, stratification, oil-water separation, etc., and had good low-temperature stability. However, the control group of commercial sunscreens showed oil-water separation after centrifugation, and had relatively poor low-temperature stability.

[0089] (II) Sunscreen sunscreen effect test

[0090] Weigh 0.10 g of the obtained sunscreen and the purchased commercially available sunscreen (Mistin facial sunscreen), add 30 mL of 95% ethanol solution, use an ultrasonic extractor to completely mix them at 40°C, 45 kHz, then use 95% ethanol to make the volume to 50 mL, and take 5 mL to make the volume to 25 mL; use an ultraviolet spectrophotometer to scan at a wavelength of 280 nm to 400 nm to obtain its ultraviolet absorption spectrum, calculate its average absorbance in the UVA region and the UVB region, respectively, and evaluate the effect according to the evaluation method for the sunscreen effect of sunscreen cosmetics in the UVB region specified in QB / T2410-1998, as shown in Table 4.

[0091] Table 4 Evaluation criteria for sun protection effect

[0092]

[0093] The average absorbance of each prepared sunscreen is shown in Table 5. Fig. 9 shown.

[0094] Table 5 Average absorbance of sunscreen

[0095]

[0096]

[0097] Referring to the standards of average absorbance in the UVB zone and sunscreen effect, it was found that formula 1 (Scutellaria baicalensis: Coptis chinensis: Sophora japonica seed: Curcuma longa = 2:3:2:3) has a high ultraviolet protection effect; formula 2 (Scutellaria baicalensis: Evodia rutaecarpa: Sophora japonica seed: Curcuma longa = 1:2:1:2) and formula 3 (Evodia rutaecarpa: Coptis chinensis: Sophora japonica seed: Curcuma longa = 1:2:1:2) have moderate ultraviolet protection effects; the safflower control has the smallest ultraviolet protection effect; and the commercially available sunscreen control has a complete ultraviolet protection effect.

[0098] Currently, there is no relevant standard for the relationship between the sunscreen effect and the average absorbance in the UVA zone. By comparing with the standard of the average absorbance and the sunscreen effect in the UVB zone, Formula 1, Formula 2, and Formula 3 all have moderate UV protection effects, the safflower control has the smallest UV protection effect, and the commercially available sunscreen control has no sunscreen effect.

[0099] Formulas 1, 2, and 3 have strong ultraviolet absorption effects in both the UVA and UVB regions, and are ideal natural broad-spectrum sunscreens, among which Formula 3 has the best ultraviolet absorption effect.

[0100] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution of the present invention, which should be covered by the scope of the claims of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: Select any one of the following compositions: (a) scutellaria baicalensis extract, coptis chinensis extract, sophora japonica extract and turmeric extract; (b) Scutellaria baicalensis extract, Evodia rutaecarpa extract, Sophora japonica extract and Curcuma longa extract; (c) Evodia rutaecarpa extract, Coptis chinensis extract, Sophora japonica seed extract and Curcuma longa extract.

2. The Chinese medicine composition according to claim 1, characterized in that: The volume ratio of Scutellaria baicalensis extract, Coptis chinensis extract, Sophora japonica seed extract and turmeric extract is 2:3:2:3; the volume ratio of Scutellaria baicalensis extract, Evodia rutaecarpa extract, Sophora japonica seed extract and turmeric extract is 1:2:1:2; the volume ratio of Evodia rutaecarpa extract, Coptis chinensis extract, Sophora japonica seed extract and turmeric extract is 1:2:1:

2.

3. The Chinese medicine composition according to claim 1 or 2, characterized in that: The preparation method of the Chinese medicine extract comprises: drying the Chinese medicine raw material, crushing to obtain Chinese medicine powder, mixing the Chinese medicine powder with ethanol, heating and soaking, ultrasonic extraction, and filtering to obtain a filtrate, namely the Chinese medicine extract.

4. The Chinese medicine composition according to claim 3, characterized in that: The preparation method of the scutellaria baicalensis extract comprises: drying and crushing the scutellaria baicalensis to obtain scutellaria baicalensis powder, soaking the scutellaria baicalensis powder in 75% ethanol by mass, heating, ultrasonically extracting at 60°C for 60 minutes, and filtering to obtain a filtrate, namely the scutellaria baicalensis extract; The preparation method of the coptis chinensis extract comprises: drying the coptis chinensis, crushing the coptis chinensis to obtain coptis chinensis powder, soaking the coptis chinensis powder in 75% ethanol by mass, heating, ultrasonically extracting at 50°C for 60 minutes, and filtering to obtain a filtrate, namely the coptis chinensis extract; The preparation method of the Evodia rutaecarpa extract comprises: drying the Evodia rutaecarpa, crushing the Evodia rutaecarpa to obtain Evodia rutaecarpa powder, soaking the Evodia rutaecarpa powder in 50% ethanol by mass, heating, ultrasonically extracting at 60° C. for 60 minutes, and filtering to obtain a filtrate, namely the Evodia rutaecarpa extract; The preparation method of the sophora japonica extract comprises: drying and crushing scutellaria baicalensis to obtain sophora japonica powder, soaking the sophora japonica powder in 50% ethanol by mass, heating, ultrasonically extracting at 50°C for 50 minutes, and filtering to obtain a filtrate, namely the sophora japonica extract; The preparation method of turmeric extract comprises: drying turmeric, crushing turmeric to obtain turmeric powder, soaking the turmeric powder in 75% ethanol by mass, heating, ultrasonically extracting at 50°C for 50 minutes, and filtering to obtain a filtrate, namely, turmeric extract.

5. A sunscreen, characterized in that The sunscreen is composed of an oil phase and a water phase. The oil phase comprises white vaseline, lanolin, cetyl alcohol, stearic acid, Tween-80 and glyceryl monostearate; the water phase comprises glycerin, methyl parahydroxybenzoate, sodium copper ethylenediaminetetraacetate, the traditional Chinese medicine composition according to any one of claims 1 to 4 and the balance water.

6. The sunscreen according to claim 5, characterized in that The mass fraction of the Chinese medicine composition in the sunscreen is 2.5%-3.5%.

7. The sunscreen according to claim 6, characterized in that The mass fractions of vaseline, lanolin, cetyl alcohol, stearic acid, Tween-80, glyceryl monostearate, glycerin, methyl paraben, sodium copper ethylenediaminetetraacetate, traditional Chinese medicine composition and water in the sunscreen are 0.5%, 0.5%, 3%, 3.5%, 1.2%, 0.15%, 5%, 0.15%, 0.05%, 2.5%-3.5% and the balance is water, respectively.

8. The method for preparing the sunscreen according to any one of claims 5 to 7, characterized in that: include: (1) dissolving the raw materials in the oil phase to obtain a first solution; (2) mixing glycerol, methyl parahydroxybenzoate, sodium copper ethylenediaminetetraacetate and water in the aqueous phase, heating and adding the Chinese medicine composition to obtain a second solution; (3) Slowly adding the second solution into the first solution while stirring and emulsifying to obtain a sunscreen.

9. The preparation method according to claim 8, characterized in that: The temperature for stirring and emulsifying was 80°C.

10. The preparation method according to claim 8 or 9, characterized in that: The stirring emulsification time is 30 minutes.

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