Preparation method of compound system for protecting oxidation stability of vitamin C
By adding specific components to vitamin C to form supramolecular complexes, the problem of vitamin C instability in aqueous solution is solved, and its oxidative stability and biological activity are significantly improved, simplifying the preparation process.
Patent Information
- Application Number
- CN202411563793.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-05
- Publication Date
- 2025-02-14
AI Technical Summary
Vitamin C is extremely unstable in aqueous solution and is prone to oxidation or hydrolysis, causing it to degrade during processing or storage, affecting its bioavailability and biological activity.
By adding L-arginine, glutathione, lactoxin and sodium hyaluronate to vitamin C, non-covalent modes of action such as hydrogen bonding, aptamer inclusion, electrostatic coupling and solvation, etc. to vitamin C, it is possible to use non-covalent modes of action such as hydrogen bonding, aptamer inclusion, electrostatic coupling and solvation. , form a vitamin C supramolecular complex to enhance its oxidative stability.
It significantly improves the stability of vitamin C in aqueous solution, extends its storage time, maintains its biological activity, and simplifies the preparation process.
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Figure CN119424414A_ABST
Abstract
Description
Technical Field
[0001] The invention relates to a composite system for protecting the oxidation stability of vitamin C and a preparation method thereof, and belongs to the technical fields of chemistry, fine chemical industry and biomedicine. Background Art
[0002] Vitamin C is a water-soluble vitamin that acts as an antioxidant and free radical scavenger and can be used as one of the cheapest drugs to protect humans from infection, cancer, autoimmune diseases and poisoning. Vitamin C comes from many sources, especially vegetables and fruits. The entry of vitamin C into the human body is affected by its bioavailability and bioactivity. Factors affecting the bioavailability and bioactivity of vitamin C include pH, interaction with other organic compounds, interaction with minerals, oxygen, processing methods and lifestyle. However, vitamin C is the most perishable vitamin and is easily degraded by temperature, humidity and oxygen during processing or storage. This is the reason for the low utilization efficiency of vitamin C and affects the bioavailability and bioactivity of vitamin C. Researchers have applied various technologies to improve the bioavailability and bioactivity of vitamin C, including encapsulation processes, the use of antioxidants and the use of emulsions. In 2010, Chang Dawei et al. encapsulated vitamin C in a low glucose equivalent maltodextrin matrix by extrusion, and found that the vitamin C yield of the extrudate was higher than 96%, but the vitamin C yield decreased slightly with the increase of water content. In 2013, Talita A et al. used microfluidics to produce solid lipid microcapsules (SLM) loaded with vitamin C, demonstrating two methods to improve the encapsulation efficiency and stability of vitamin C: pore closure method and micromolecular chelators in the core. The designed medium has great potential to prevent the degradation of vitamin C in food and the carrier can mask the acidic taste of vitamin C. In 2018, Carvalho, JDD et al. used spray cooling to produce and characterize solid lipid microparticles (SLM) with different proportions of fully hydrogenated palm oil (FHPO) and palm oil (PO) as wall materials (WM) to encapsulate vitamin C, and obtained encapsulation efficiencies of 80.22% to 93.51%, respectively. However, vitamin C is extremely unstable in aqueous solution and reacts rapidly, but the use of low-cost, green, and mild solvents to solve the stability of vitamin C in aqueous solution is still a bottleneck problem in this field to improve the stability of vitamin C.
[0003] The present invention develops a vitamin C complex which can effectively enhance the oxidative stability of vitamin C and reduce the hydrolysis effect based on hydrogen bonding, aptamer inclusion, electrostatic coupling, solvation and the like, and develops an effective process and preparation method. Summary of the invention
[0004] The present invention is aimed at the deficiencies in the prior art, and develops a vitamin C complex that effectively enhances the oxidative stability of vitamin C and reduces the hydrolysis effect based on hydrogen bonding, aptamer inclusion, electrostatic coupling, solvation, etc., and develops an effective process and preparation method.
[0005] To solve the above problems, the technical solutions adopted by the present invention are as follows:
[0006] A method for preparing a composite system for protecting the oxidative stability of vitamin C, wherein the raw material composition and content thereof are as follows, calculated by mass concentration:
[0007]
[0008] The preparation method is as follows:
[0009] Step 1: Dissolve a certain amount of antioxidant, animal protein aptamer, and small molecule regulator in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then add a certain amount of VC to dissolve in phase A;
[0010] Step 2: Prepare a macromolecular polymer aqueous solution as phase B: then mix phases A and B evenly, and use a pH regulator to adjust the pH of the mixed solution system to 4.5-6.0, thereby obtaining a composite system that protects the oxidative stability of vitamin C.
[0011] As an improvement of the above technical solution, the antioxidant described in the above preparation method is one or more of glutathione, coenzyme Q10, and lipoic acid, and the mass percentage thereof is 0.02-1.0%; the animal protein aptamer is one or more of bovine serum albumin, β-lactoglobulin, whey protein, and casein, and the mass percentage thereof is 0.05-2.0%; the macromolecular polymer is one or more of sodium hyaluronate, tremella polysaccharide, dextran, and xanthan gum, and the mass percentage thereof is 0.02-0.5%; the small molecule regulator is one or more of arginine, histidine, and lysine, and the mass percentage thereof is 0.05-0.50%; the pH regulator is citric acid or triethanolamine, and the pH of the regulating system is 4.5-6.0.
[0012] Compared with the prior art, the implementation effects of the present invention are as follows:
[0013] The present invention adds L-arginine, glutathione, lactoglobulin and sodium hyaluronate to VC (vitamin C), forms a VC supramolecular complex through non-covalent interaction modes such as hydrogen bonding, aptamer inclusion, electrostatic coupling and solvation, thereby improving the stability of vitamin C in aqueous solution, does not affect the biological activity of VC itself, and the preparation method is simple and effective. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] Figure 1 The change of the solution of the vitamin C blank (a) system of the present invention after being placed in the dark for 72 hours;
[0015] Figure 2 The change of the solution of the system of Example 8(b) of the present invention after being placed in the dark for 72 hours;
[0016] Figure 3 The change of the solution of the system of Example 9(c) of the present invention after being placed in the dark for 72 hours;
[0017] Figure 4 The change of the solution of the system of Example 10(d) of the present invention after being placed in the dark for 72 hours;
[0018] Figure 5 The change of the solution of the system of Example 11(e) of the present invention after being placed in the dark for 72 hours;
[0019] Figure 6 The change of the solution of the system of Example 12(f) of the present invention after being placed in the dark for 72 hours;
[0020] Figure 7 The change of the solution of the system of Example 13(g) of the present invention after being placed in the dark for 72 hours;
[0021] Figure 8 It is the infrared spectrum of vitamin C and its compound L-arginine; Figure 8 In, A: Vitamin C; B: L-arginine C: homogeneous phase of vitamin C and L-arginine;
[0022] Fig. 9 It is the infrared spectrum of vitamin C and its compound β-lactoglobulin; Fig. 9 In the figure, A: β-lactoglobulin; B: vitamin C; C: homogeneous phase of vitamin C and β-lactoglobulin;
[0023] Fig.10 It is the infrared spectrum of vitamin C and its compound; Fig.10 In the figure, A: sodium hyaluronate; B: lactoglobulin; C: glutathione; D: vitamin C; E: L-arginine; F: homogeneous phase of vitamin C, L-arginine, lactoglobulin, glutathione and sodium hyaluronate. DETAILED DESCRIPTION
[0024] The content of the present invention will be described below with reference to specific embodiments.
[0025] Vitamin C (L-ascorbic acid, VC for short) is a water-soluble vitamin and a type of small molecule organic compound necessary for maintaining normal life activities of the body. Its main physiological functions include promoting the synthesis of collagen and connective tissue, promoting wound healing and enhancing the body's immunity, improving enzyme activity, preventing cancer, etc. It can synthesize collagen and mucopolysaccharides, reduce the damage of free radicals to the skin, delay aging, inhibit the deposition of abnormal skin pigments and the activity of tyrosinase, and reduce the formation of melanin. It is widely used in whitening and antioxidant skin care cosmetics. However, due to the conjugated structure of 2,3-enediol and lactone ring hydroxyl, vitamin C is prone to oxidation or hydrolysis to generate yellow diketone compounds, which are extremely unstable in water, thus restricting its application in cosmetics and other fields.
[0026] The preparation method in the prior art is as follows:
[0027] Chemical modification method: By changing the structure of vitamin C, vitamin C derivatives such as vitamin C acetate and vitamin C succinate are generated. However, these methods change the original structure of vitamin C, resulting in a significant decrease in the biological activity of VC.
[0028] Physical modification method: When the pH is below 3.0, vitamin C is most stable, but it is highly irritating to the skin and unsafe when used in products. It is usually necessary to adjust the value to a weakly acidic environment to keep the stability of the substance at its best, but overly acidic and overly alkaline environments limit the application scenarios of active substances. By isolating the oxygen in the environment with nitrogen, vitamin C can be protected from oxidation and its stability can be improved. This method makes the production process complicated and increases production costs.
[0029] Physical coating or secondary sealing forms, using microcapsules to coat vitamin C to improve the stability of vitamin C, but this method makes the production process complicated and increases the cost.
[0030] The present invention develops a vitamin C complex which can effectively enhance the oxidative stability of vitamin C and reduce the hydrolysis effect based on hydrogen bonding, aptamer inclusion, electrostatic coupling, solvation and the like, and develops an effective process and preparation method.
[0031] Example 1
[0032] 0.05g Tremella polysaccharide was dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent. As shown in Table 1, compared with the VC aqueous solution retention rate of 36.83% at the same concentration, the uniform phase system formed by adding only Tremella polysaccharide had a retention rate of 34.53%, and this composite system did not play a protective role in the oxidative stability of VC.
[0033] Example 2
[0034] 0.05g L-arginine was dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to the phase A, and the pH of the mixed solution system was adjusted to 5.0 using triethanolamine, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The VC retention rate after adding the protective agent was investigated using the 10.00% VC aqueous solution itself after 72h as a control, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the VC aqueous solution retention rate of 36.83% at the same concentration, the retention rate of the uniform phase system formed by adding only L-arginine was 48.64%, and this composite system had no obvious protective effect on the oxidative stability of VC.
[0035] Example 3
[0036] 0.05g of anhydrous glucose was dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g of VC was added to the phase A, and the pH of the mixed solution system was adjusted to 5.0 using triethanolamine, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the VC aqueous solution retention rate of 36.83% at the same concentration, the retention rate of the uniform phase system formed by adding only anhydrous glucose was 39.13%, and this composite system had almost no protective effect on the oxidative stability of VC.
[0037] Example 4
[0038] 0.05g of glutathione was dissolved in deionized water by stirring and dissolving to obtain a uniform phase A, and then 10.00g of VC was added to the phase A, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the 36.83% retention rate of the VC aqueous solution at the same concentration, the retention rate of the uniform phase system formed by adding only glutathione was 59.63%, and this composite system greatly increased the oxidative stability of VC.
[0039] Example 5
[0040] 1.00g of fetal bovine serum albumin was dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g of VC was added to dissolve in phase A, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the VC aqueous solution retention rate of 36.83% at the same concentration, the retention rate of the uniform phase system formed by adding only fetal bovine serum albumin was 52.90%, and this composite system greatly increased the oxidative stability of VC.
[0041] Example 6
[0042] 10.00g of VC was added to a 0.50% sodium hyaluronate aqueous solution, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the 36.83% retention rate of the VC aqueous solution at the same concentration, the retention rate of the homogeneous phase system formed by adding only sodium hyaluronate was 57.99%, and this composite system greatly increased the oxidative stability of VC.
[0043] Example 7
[0044] 0.01g of lipoic acid was dissolved in deionized water by stirring and dissolving to obtain a uniform phase A, and then 10.00g of VC was added to the phase A, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent, and the experimental results are shown in Table 1. As can be seen from Table 1, compared with the VC aqueous solution retention rate of 36.83% at the same concentration, the retention rate of the uniform phase system formed by adding only lipoic acid was 52.58%, and this composite system greatly increased the oxidative stability of VC.
[0045] Example 8
[0046] 0.05g glutathione, 1.00g fetal bovine serum albumin and 0.05g arginine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% sodium hyaluronate aqueous solution was prepared as phase B. Phases A and B were then mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 4.5, thereby obtaining a composite system for protecting the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself was used as a control after 72 hours to investigate the retention rate of VC after the addition of the protective agent. The experimental results are shown in Table 1. After adding the VC supramolecular complex protective agent, the retention rate of VC was 66.68%, which greatly increased the oxidative stability of VC. After the solution was placed away from light for 72 hours, the vitamin C blank solution became yellow and transparent. Compared with the blank sample, Figure 2 There is almost no obvious color change, which shows that the vitamin C solution is relatively stable.
[0047] Example 9
[0048] 0.01g lipoic acid, 1.00g fetal bovine serum albumin, and 0.05g arginine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% sodium hyaluronate aqueous solution was prepared as phase B. Then, phases A and B were mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system that protects the oxidative stability of vitamin C. The 10.00% VC aqueous solution itself after 72 hours was used as a control to examine the oxidative stability of VC after adding the protective agent. The experimental results are as follows: Figure 1 , 3 As shown in Table 1, compared with the control, the retention rate of VC after adding the VC supramolecular complex protective agent is 63.40%, which greatly increases the oxidative stability of VC. After the solution is placed away from light for 72 hours, the vitamin C blank solution is yellow and transparent. Compared with the blank sample, Figure 3 There is almost no obvious color change, which shows that the vitamin C solution is relatively stable.
[0049] Example 10
[0050] 0.05g glutathione, 2.00g lactoglobulin, and 0.05g arginine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% Tremella polysaccharide aqueous solution was prepared as phase B. Then, phases A and B were mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 5.5, thus obtaining a composite system that protects the oxidative stability of vitamin C. The 10% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent. The experimental results are as follows: Figure 1 , 4 As shown in Table 1, the retention rate of VC after adding the VC supramolecular complex protective agent is 65.69%, which greatly increases the oxidative stability of VC. After the solution is placed away from light for 72 hours, the vitamin C blank solution is yellow and transparent. Compared with the blank sample, Figure 4 There is no obvious color change, which shows that the vitamin C solution is relatively stable.
[0051] Embodiment 11
[0052] 0.05g glutathione, 2.00g lactoglobulin, and 0.05g arginine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% sodium hyaluronate solution was prepared as phase B. Then, phases A and B were mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 6.0, thus obtaining a composite system that protects the oxidative stability of vitamin C. The 10% VC aqueous solution itself was used as a control after 72 hours to examine the VC retention rate after adding the protective agent. The experimental results are as follows: Figure 1 , 5 As shown. After adding the VC supramolecular complex protective agent, the retention rate of VC was 79.80%, which greatly increased the oxidative stability of VC. After the solution was placed away from light for 72 hours, the vitamin C blank solution was yellow and transparent. Compared with the blank sample, Figure 5 There is no color change, which shows that the vitamin C solution is relatively stable.
[0053] Example 12
[0054] 0.10g glutathione, 2.00g lactoglobulin, and 0.05g histidine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% sodium hyaluronate solution was prepared as phase B. Then, phases A and B were mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 5.0, thus obtaining a composite system that protects the oxidative stability of vitamin C. The 10% VC aqueous solution itself was used as a control after 72 hours to investigate the VC retention rate after adding the protective agent. The experimental results are as follows: Figure 1 , 6 As shown. After adding the VC supramolecular complex protective agent, the retention rate of VC was 60.77%, which greatly increased the oxidative stability of VC. After the solution was placed away from light for 72 hours, the vitamin C blank solution was yellow and transparent. Compared with the blank sample, Figure 6 The solution is light yellow in color but lighter than the blank solution. It can be seen that the system improves the stability of the vitamin C solution.
[0055] Embodiment 13
[0056] 0.05g glutathione, 1.00g lactoglobulin, and 0.02g arginine were dissolved in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then 10.00g VC was added to dissolve in phase A. At the same time, a 0.50% sodium hyaluronate solution was prepared as phase B. Then, phases A and B were mixed evenly, and triethanolamine was used to adjust the pH of the mixed solution system to 6.0, thus obtaining a composite system that protects the oxidative stability of vitamin C. The 10% VC aqueous solution itself was used as a control after 72 hours to examine the VC retention rate after adding the protective agent. The experimental results are as follows: Figure 1 , 7 As shown. After adding the VC supramolecular complex protective agent, the retention rate of VC was 69.63%, which greatly increased the oxidative stability of VC. After the solution was placed away from light for 72 hours, the vitamin C blank solution was yellow and transparent. Compared with the blank sample, Figure 7 The solution is slightly yellow in color, and it can be seen that the system improves the stability of the vitamin C solution.
[0057] In order to improve the stability of the vitamin C system, the stability of the vitamin C aqueous solution of Examples 1-6 was studied respectively, and the retention rate of the vitamin C aqueous solution after dilution was measured by UV-visible spectrophotometer after 72 hours ( c n : VC concentration in the mixed solution on the nth day, c0: initial VC concentration), the results are shown in Table 1.
[0058] Table 1 VC aqueous solution 72h retention rate under different protection conditions %
[0059] name Retention rate (%) VC Blank 36.83 Example 1 34.53 Example 2 48.64 Example 3 39.13 Example 4 59.63 Example 5 52.90 Example 6 57.99 Example 7 52.58 Example 8 66.68 Example 10 63.40 Embodiment 11 79.80 Example 12 60.77 Embodiment 13 69.63
[0060] According to the proportions of Examples 1-4, it was investigated whether VC and each active component formed a small molecule binding system, rather than simply mixing, which had a protective effect on the stability of VC. First, the interaction between vitamin C and L-arginine was studied by infrared spectroscopy ( Figure 8 ), as can be seen from the figure, at 1355cm-1 is a hydroxyl stretching weak vibration peak in the enol structure of vitamin C, at 1401cm-1 is a weak vibration peak of L-arginine amide, as arginine and vitamins are mixed, molecules collide, and it is found that strong and wide vibration bands are presented at 1401 and 1355cm-1, which is due to the combination of the amide of L-arginine and a hydroxyl hydrogen bond in the enol structure of vitamin C. In addition, compared to arginine and VC themselves, the strong vibration band also presented by the mixture system at 3351cm-1 is due to the combination of the amine linked by the carbon-nitrogen double bond of L-arginine and another hydroxyl in the enol structure of vitamin C. The above explanation shows that after arginine and VC are mixed, the guanidine amine of arginine and the enol hydroxyl of VC form a complex through static electricity and hydrogen bonding.
[0061] Furthermore, the interaction between vitamin C and β-lactoglobulin was investigated using infrared spectroscopy. Fig. 9 Compared with VC and lactoglobulin itself, the complex of lactoglobulin and VC has a strong vibration band at 1392cm-1. This is due to the β-folding of lactoglobulin caused by the aptamer inclusion effect between the two hydroxyl groups in the enol structure of vitamin C and the carboxyl groups in the β-lactoglobulin structure, indicating that β-lactoglobulin and VC form a more stable conjugate.
[0062] Furthermore, the interaction between vitamin C and L-arginine and lactoglobulin homogeneous phase was studied. Fig.10 As shown in the figure, compared with the single system of vitamin C, L-arginine and lactoglobulin, the infrared spectrum of the composite system has new peaks at 2930 and 1392 cm-1, which is due to the aptamer inclusion reaction between the hydroxyl group of vitamin C and the hydroxyl group of L-arginine and lactoglobulin respectively. The above results show that vitamin C forms supramolecular aggregates after compounding with L-arginine and lactoglobulin, which promotes the stability of the vitamin C structure. In addition, the glutathione and hyaluronic acid system assisted in enhancing the stability of VC.
[0063] The above content is a detailed description of the present invention in combination with specific embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For those skilled in the art of the present invention, without departing from the concept of the present invention, several simple deductions or substitutions can be made, which should be regarded as falling within the scope of protection of the present invention.
Claims
1. A method for preparing a composite system for protecting the oxidative stability of vitamin C, characterized in that: Calculated by mass concentration, the raw material composition and content are as follows: The preparation method is as follows: Step 1: Dissolve a certain amount of antioxidant, animal protein aptamer, and small molecule regulator in deionized water by stirring and ultrasonic dissolution to obtain a uniform phase A, and then add a certain amount of VC to dissolve in phase A; Step 2: Prepare a macromolecular polymer aqueous solution as phase B: then mix phases A and B evenly, and use a pH regulator to adjust the pH of the mixed solution system to 4.5-6.0, thereby obtaining a composite system that protects the oxidative stability of vitamin C.
2. A method for preparing a composite system for protecting the oxidative stability of vitamin C as claimed in claim 1, characterized in that: The antioxidant is one or more of glutathione, coenzyme Q10, and lipoic acid, and the mass percentage thereof is 0.02-1.0%; the animal protein aptamer is one or more of bovine serum albumin, β-lactoglobulin, whey protein, and casein, and the mass percentage thereof is 0.05-2.0%; the macromolecular polymer is one or more of sodium hyaluronate, tremella polysaccharide, dextran, and xanthan gum, and the mass percentage thereof is 0.02-0.5%; the small molecule regulator is one or more of arginine, histidine, and lysine, and the mass percentage thereof is 0.05-0.50%; the pH regulator is citric acid or triethanolamine, and the pH of the regulating system is 4.5-6.0.