Kumquat and bletilla striata buccal tablet and preparation method thereof
By mixing Jinguan powder and Bletilla powder in equal proportions and adding auxiliary materials system, the tableting method is used to prepare Jinguan Bletilla Lozenges, which solves the lack of mixed use of Jinguan and Bletilla in the existing technology, and achieves product stability and market Improvement of potential.
Patent Information
- Application Number
- CN202411223297.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-03
- Publication Date
- 2025-02-14
AI Technical Summary
There has been no research on the use of mixed citrine and Bletilla in the prior art, which has led to the inadequate use of its potential in the field of medicine.
Jintang Bletilla Lotion tablets are prepared by mixing Jintang powder and Bletilla powder in equal proportions and adding auxiliary materials (including sweeteners, lubricants, disintegrants, wetting agents and fillers).
It realizes effective mixing and stability of tangerine and Bletilla striata, simplifies the production process, facilitates transportation and preservation, has good market potential and broad application prospects.
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Figure SMS_1 
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a kumquat and bletilla striata lozenge and a preparation method thereof. Background Art
[0002] Kumquat is a kind of fruit of the genus Kumquat of the Rutaceae family, which is a close relative of the genus Citrus. It is also known as kumquat, golden jujube, etc. Kumquat is rich in kumquat glycosides, vitamin C, flavonoids, limonin and other biologically active ingredients, and is a fruit with high nutritional value. According to the Compendium of Materia Medica, kumquat has the effects of "reducing qi, quenching thirst, relieving fishy smell, and preventing body odor". Modern pharmacological studies have shown that kumquat has the effects of lowering blood sugar, blood pressure, blood lipids, antibacterial and antiviral. Bletilla striata is the name of a traditional Chinese medicine. From September to October every year, when the stems and leaves of Bletilla striata wither, the tubers are dug, the fibrous roots are removed, washed, boiled in boiling water until there is no white heart, dried until half dry, the outer skin is removed and dried for medicinal use. Bletilla striata tastes bitter, sweet, astringent, and is slightly cold in nature. It belongs to the lung, liver, and stomach meridians. In the past decade, scholars at home and abroad have conducted extensive research and discussion on the medicinal value of Bletilla striata, and found that Bletilla striata has a variety of pharmacological effects, including antibacterial, antiviral, anti-tumor, antioxidant, hemostatic and wound healing. At present, it is clinically used for the treatment of cerebral hemorrhage, vaginal bleeding, airway bleeding, peptic ulcer, ulcerative colitis, anal fistula, perianal abscess, tuberculosis and chloasma. There is no research on the mixed use of the two, but according to the analysis of the ingredients, the mixed use of the two is beneficial to health. Therefore, the market for Kumquat Bletilla striata lozenges is broad and has great potential.
[0003] The invention uses kumquat and bletilla striata as main ingredients to produce a kumquat and bletilla striata lozenge which is beneficial to human health and has a longer shelf life, thereby opening a new way for the types and production of lozenges and also having important significance for traditional Chinese medicine treatment and carrying. Summary of the invention
[0004] The technical problem to be solved by the present invention is to overcome the deficiencies and defects mentioned in the above background technology and provide a Kumquat Bletilla striata lozenge. The method has the unique advantages of good stability, simple and flexible design, convenient transportation and storage, etc., which are easy to promote and use on a large scale and have great potential and broad prospects in the market.
[0005] The technical solution adopted by the present invention is:
[0006] The invention discloses a kumquat and bletilla striata lozenge, which takes kumquat powder and bletilla striata powder as main components, and the kumquat powder and bletilla striata powder have the same mass parts.
[0007] Preferably, the composition further comprises an auxiliary material system, which includes a sweetener, a lubricant, a disintegrant, a wetting agent and a filler.
[0008] Preferably, the sweetener is white sugar powder, with a mass fraction of 12.5 parts.
[0009] Preferably, the lubricant is magnesium stearate, with a mass fraction of 0.5-0.8 parts.
[0010] Preferably, the disintegrant is microcrystalline cellulose, with a mass fraction of 5 parts.
[0011] Preferably, the wetting agent is pure water, with a mass fraction of .
[0012] Preferably, the filler is starch, with a mass fraction of 8 parts.
[0013] The reaction principle is as follows: a variety of active ingredients, including flavonoids, alkaloids and volatile oils, were isolated and identified from kumquat. Literature shows that flavonoids, especially hesperidin, naringenin, nobiletin, naringin, tangeretin, hesperidin and eriodictyol are the main representative biologically active ingredients of kumquat, with important antioxidant, anti-tumor, antibacterial and other biological activities. At the same time, citrus flavonoids are safe and non-toxic, easy to separate, and have very high research and development value. They have been widely used in food processing, medicine and other aspects. The antioxidant effect of citrus flavonoids, its antioxidant capacity is significantly positively correlated with the total amount of flavonoid components, and its active mechanism research mainly has the following three pathways: directly scavenging free radicals, increasing the content of antioxidant substances in the body and chelating variable-valence metal ions. In the current literature reports, the main active ingredients of Bletilla striata are glycosides, bibenzyls, phenanthrenes and their derivatives, a small amount of volatile oils, etc. Polysaccharide is the main active ingredient of the traditional Chinese medicine Bletilla striata. It has physiological functions such as anti-oxidation, anti-tumor, antibacterial, immune regulation, anti-inflammatory, hypoglycemic, and hypolipidemic, and is widely used in the fields of health food, medicine, and cosmetics. Bletilla striata polysaccharide can improve the body's immune function as a whole, enhance the body's ability to scavenge free radicals, delay aging, and prevent and treat senile diseases. At the same time, due to its large molecular weight and significant bioadhesion properties, it has excellent clinical performance in gel formation, swelling, biomolecule binding, and adhesion. It can not only be used as a filler for traditional dosage forms, but also as a functional material for new drug preparations.
[0014] A method for preparing kumquat and bletilla striata tablets, the preparation method comprising the following steps:
[0015] (1) Preparation of kumquat and bletilla powder: fresh kumquat fruit is washed, stems and cores are removed, and pre-frozen in a refrigerator at -40°C or above for more than 48 hours, freeze-dried for 1 week, and the dried fruit is put into a grinder for crushing to obtain kumquat powder; bletilla tubers are selected, fibrous roots are removed, washed, boiled in boiling water until there is no white core, air-dried to half dry, the outer skin is removed and dried, and the dried bletilla tubers are put into a grinder for crushing to obtain bletilla powder;
[0016] (2) Preparation of Kumquat and Bletilla striata lozenges: Mix equal amounts of Kumquat powder and Bletilla striata powder evenly, sieve, and then add other auxiliary materials in sequence and mix evenly, including 12.5 parts by weight of granulated sugar, 0.5-0.8 parts by weight of magnesium stearate, 5 parts by weight of microcrystalline cellulose, and 8 parts by weight of starch, sieve, add 0.8-1.2 parts of wetting agent to the material that has passed the sieve, add a small amount each time, and stir continuously to make it fully and evenly wetted, put it into a tablet press for tableting, and dry it after tableting to form the lozenges to obtain Kumquat and Bletilla striata lozenges.
[0017] The beneficial effects of the present invention are:
[0018] The present invention uses kumquat powder and bletilla tuber powder as main ingredients, adds auxiliary materials and moistens with water to form tablets by direct tableting, and patients take the tablets orally to play their activity in the body, release substances beneficial to the human body, and thus achieve the effect beneficial to human health. The method has good stability, simple and flexible design, convenient transportation and storage and other unique advantages, the operation process can be mastered without professional training, and it is easy to promote and use on a large scale, and has great potential and broad prospects in the market. The formula of the present invention is of great significance in the promotion of human health and traditional Chinese medicine treatment. BRIEF DESCRIPTION OF THE DRAWINGS
[0019] Figure 1 A product diagram of the present invention;
[0020] Figure 2 This is a production flow chart of the product described in the present invention;
[0021] Figure 3 This is a graph of the single factor experiment results described in the present invention. DETAILED DESCRIPTION
[0022] In order to make the purpose, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0023] Example 1
[0024] A kumquat and bletilla lozenge, with kumquat powder and bletilla powder as main ingredients, and the kumquat powder and bletilla powder have the same mass fraction. Preferably, it also comprises an auxiliary material system, and the auxiliary material system includes a sweetener, a lubricant, a disintegrant, a wetting agent, and a filler. The sweetener is white granulated sugar powder, and the mass fraction is 12.5 parts. The lubricant is magnesium stearate, and the mass fraction is 0.5-0.8 parts. The disintegrant is microcrystalline cellulose, and the mass fraction is 5 parts. The wetting agent is purified water, and the mass fraction is 0.8-1.2 parts. The filler is selected from starch, and the mass fraction is 8 parts.
[0025] A method for preparing kumquat and bletilla striata tablets, the preparation method comprising the following steps:
[0026] (1) Preparation of kumquat and bletilla powder: fresh kumquat fruit is washed, stems and cores are removed, and pre-frozen in a refrigerator at -40°C or above for more than 48 hours, freeze-dried for 1 week, and the dried fruit is put into a grinder for crushing to obtain kumquat powder; bletilla tubers are selected, fibrous roots are removed, washed, boiled in boiling water until there is no white core, air-dried to half dry, the outer skin is removed and dried, and the dried bletilla tubers are put into a grinder for crushing to obtain bletilla powder;
[0027] (2) Preparation of Kumquat and Bletilla striata lozenges: Mix equal amounts of kumquat powder and Bletilla striata powder evenly, sieve, and then add other auxiliary materials in turn and mix evenly, 12.5 parts by mass of granulated sugar, 0.5-0.8 parts by mass of magnesium stearate, 5 parts by mass of microcrystalline cellulose, 8 parts by mass of starch, sieve, add 0.8-1.2 parts of wetting agent to the material that has passed the sieve, add a small amount each time, and stir continuously to make it fully and evenly wetted, put it into a tablet press for tableting, and dry it after tableting to form the lozenges to obtain Kumquat and Bletilla striata lozenges. The shape of Kumquat and Bletilla striata lozenges is as follows Figure 1 The preparation process is as shown in Figure 2 shown.
[0028] Example 2
[0029] Specificity experiments:
[0030] Through a single factor experimental design, different proportions of auxiliary materials were added to the reaction system described in Example 1 as controls, and the lozenges were prepared and subjected to sensory analysis and evaluation. The sensory analysis and evaluation are described in Table 1. Figure 3 It was found that the kumquat and bletilla striata lozenges prepared in Example 1 had the best taste and flavor, which further proved the practicality and specificity of the formula.
[0031] Table 1 is a table of sensory evaluation standards of the present invention
[0032]
Claims
1. A Kumquat and Bletilla striata lozenge, characterized in that: The main components are kumquat powder and bletilla striata powder, and the kumquat powder and bletilla striata powder have the same mass fraction.
2. The Kumquat Bletilla striata buccal tablet according to claim 1, characterized in that: The invention also comprises an auxiliary material system, which comprises a sweetener, a lubricant, a disintegrant, a wetting agent and a filler.
3. The Kumquat Bletilla striata buccal tablet according to claim 2, characterized in that: The sweetener is white sugar powder, with a mass fraction of 12.5 parts.
4. The Kumquat Bletilla striata buccal tablet according to claim 3, characterized in that: The lubricant is magnesium stearate, with a mass fraction of 0.5-0.8 parts.
5. The Kumquat Bletilla striata buccal tablet according to claim 4, characterized in that: The disintegrant is microcrystalline cellulose, with a mass fraction of 5 parts.
6. The Kumquat and Bletilla striata buccal tablet according to claim 5, characterized in that: The wetting agent is pure water, with a mass fraction of 0.8-1.2 parts.
7. The Kumquat and Bletilla striata buccal tablet according to claim 6, characterized in that: The filler is starch, with a mass fraction of 8 parts.
8. The method for preparing the Kumquat Bletilla striata tablets according to any one of claims 1 to 7, characterized in that: The preparation method comprises the following steps: (1) Preparation of kumquat and bletilla powder: fresh kumquat fruit is washed, stems and cores are removed, and pre-frozen in a refrigerator at -40°C or above for more than 48 hours, freeze-dried for 1 week, and the dried fruit is put into a grinder for crushing to obtain kumquat powder; bletilla tubers are selected, fibrous roots are removed, washed, boiled in boiling water until there is no white core, air-dried to half dry, the outer skin is removed and dried, and the dried bletilla tubers are put into a grinder for crushing to obtain bletilla powder; (2) Preparation of Kumquat and Bletilla striata lozenges: Mix equal amounts of Kumquat powder and Bletilla striata powder evenly, sieve, and then add other auxiliary materials in sequence and mix evenly, including 12.5 parts by weight of granulated sugar, 0.5-0.8 parts by weight of magnesium stearate, 5 parts by weight of microcrystalline cellulose, and 8 parts by weight of starch, sieve, add 0.8-1.2 parts of wetting agent to the material that has passed the sieve, add a small amount each time, and stir continuously to make it fully and evenly wetted, put it into a tablet press for tableting, and dry it after tableting to form the lozenges to obtain Kumquat and Bletilla striata lozenges.