Perfusion system and ventricular assist device

Abstract

The invention relates to a perfusion system and a ventricular auxiliary device, and the perfusion system comprises an infusion module which comprises an infusion channel; the perfusion module comprises a liquid inlet end and a liquid outlet end, and the perfusion module is connected in series in the infusion channel through the liquid inlet end and the liquid outlet end; the bubble monitoring module is arranged on one side, close to the liquid inlet end, of the filling module and is used for monitoring bubbles in liquid flowing into the liquid inlet end from the liquid conveying channel; the pressure monitoring module is arranged on the side, close to the liquid outlet end, of the filling module, communicates with the liquid outlet end through the liquid conveying channel and is used for monitoring the pressure of liquid flowing out of the liquid outlet end; and the control module is electrically connected with the bubble monitoring module and the pressure monitoring module. By integrating the bubble monitoring module and the pressure monitoring module, effective monitoring and control of bubbles and pressure in the perfusion process are achieved, the safety and stability of the perfusion process are ensured, and a good treatment environment is provided for a patient.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a perfusion system and a ventricular assist device. Background Art

[0002] Percutaneous left ventricular assist device (PLVAD) is an important device for treating heart failure. Its working principle is to effectively pump the blood in the patient's left ventricle to the aorta through the built-in micro blood pump, so as to assist the heart to complete blood circulation and reduce the burden on the heart. During the operation of PLVAD, in order to ensure the stability and efficiency of the blood pump, a perfusion device is usually set up to deliver perfusion fluid to the blood pump for cooling and lubricating the blood pump to prevent it from overheating and wear. It can also effectively prevent the formation of blood clots and significantly reduce the risk of hemolysis, thereby improving the overall treatment effect.

[0003] In the perfusion system of PLVAD, accurate monitoring of the perfusion process is crucial. Key parameters such as flow, flow rate and pressure must be monitored in real time and regulated within a reasonable range to ensure the normal operation of the equipment. Once these parameters are abnormal, the system should provide feedback immediately so that timely measures can be taken to avoid potential risks.

[0004] The outside of traditional piezoresistive diffused silicon sensors is usually filled with non-corrosive, low-compression-coefficient insulating liquid as a pressure-transmitting medium. Despite this, the existing perfusion system has certain deficiencies in detecting bubbles in the pipeline. At present, the system mainly determines whether there are bubbles in the pipeline by analyzing the pressure waveform. However, this method has hysteresis, and the ability to resolve single small bubbles or dense small bubbles is limited, and the minimum bubble capacity that can be resolved is relatively large. This means that when the number of bubbles is small or the volume is small, the system may not be able to detect them in a timely and accurate manner, thereby increasing potential risks. Summary of the invention

[0005] Based on this, it is necessary to provide a perfusion system and a ventricular assist device to address the problems of untimely bubble detection and insufficient pressure detection accuracy in the existing perfusion system.

[0006] A perfusion system comprising:

[0007] An infusion module, including an infusion channel;

[0008] A perfusion module, comprising a liquid inlet end and a liquid outlet end, wherein the perfusion module is connected in series in the infusion channel via the liquid inlet end and the liquid outlet end;

[0009] A bubble monitoring module, arranged on a side of the perfusion module close to the liquid inlet end, for monitoring bubbles in the liquid flowing into the liquid inlet end through the infusion channel;

[0010] A pressure monitoring module, which is arranged on a side of the perfusion module close to the liquid outlet, is connected to the liquid outlet through the infusion channel, and is used to monitor the pressure of the liquid flowing out of the liquid outlet;

[0011] The control module is electrically connected to the bubble monitoring module and the pressure monitoring module respectively.

[0012] In one embodiment, the pressure monitoring module includes a pressure plate, a pressure cover, a strain gauge bridge and a circuit board, the strain gauge bridge is arranged on the circuit board, the pressure cover is arranged on the side of the strain gauge bridge away from the circuit board, and the pressure plate is arranged on the side of the pressure cover away from the strain gauge bridge; the pressure plate is connected to the infusion channel, and the pressure plate is used to transmit pressure to the strain gauge bridge through the pressure cover.

[0013] In one embodiment, the pressure plate includes a chamber and a flexible membrane, wherein the flexible membrane is arranged on a side of the chamber close to the pressure shield; an inlet and an outlet connected to the infusion channel are respectively arranged on both sides of the chamber, and when the perfusion liquid flows through the chamber, the flexible membrane expands and squeezes the pressure shield.

[0014] In one embodiment, the perfusion system includes a housing, the pressure monitoring module includes a socket, the socket is disposed in the housing, and the pressure disc is connected to the socket.

[0015] In one of the embodiments, the pressure monitoring module also includes a photoelectric trigger baffle, a photoelectric switch and a torsion spring, the photoelectric switch is arranged on a circuit board, one end of the photoelectric trigger baffle is electrically connected to the photoelectric switch, and the other end is abutted against the pressure plate; the photoelectric trigger baffle is movably arranged on the surface of the card seat through a fixing pin, the torsion spring is sleeved on the fixing pin, and the two ends of the torsion spring are respectively embedded in the side walls of the card seat.

[0016] In one embodiment, the perfusion module includes a perfusion box, a plunger pump and a motor, the perfusion box includes the liquid inlet end and the liquid outlet end, the plunger pump is disposed in the perfusion box, and the motor is used to drive the plunger pump to move.

[0017] In one embodiment, a one-way valve is provided between the infusion channel and the liquid inlet end, and between the liquid outlet end and the infusion channel.

[0018] In one embodiment, the perfusion system further comprises an air filtration module, wherein the air filtration module is disposed at an end of the pressure monitoring module away from the perfusion module, and the air filtration module is connected to the pressure monitoring module through the infusion channel.

[0019] In one embodiment, the perfusion system further comprises a pressure maintaining module, wherein the pressure maintaining module is disposed at one end of the air filtering module away from the pressure monitoring module, and the pressure maintaining module is connected to the air filtering module through the infusion channel.

[0020] The above-mentioned perfusion system, by integrating the bubble monitoring module and the pressure monitoring module, realizes the effective monitoring and control of the bubbles and pressure during the perfusion process, ensures the safety and stability of the perfusion process, and provides a good treatment environment for patients.

[0021] According to another object of the present invention, a ventricular assist device is provided, comprising the perfusion system as described above; the perfusion system is connected to the ventricular assist device.

[0022] The above-mentioned ventricular assist device is connected to the perfusion system to achieve precise control, real-time monitoring and high safety assurance of the perfusion process. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a schematic diagram of the structure of the perfusion system.

[0024] FIG. 2 is a structural schematic diagram 1 of the pressure monitoring module.

[0025] FIG. 3 is a second structural diagram of the pressure monitoring module.

[0026] FIG. 4 is an exploded schematic diagram of a pressure monitoring module.

[0027] FIG. 5 is a schematic structural diagram of a perfusion module.

[0028] FIG. 6 is a schematic cross-sectional view of a perfusion module.

[0029] In the figure: 1. perfusion module; 10. liquid inlet end; 11. liquid outlet end; 12. perfusion box; 13. plunger pump; 130. inner tube; 131. outer tube; 132. liquid inlet; 133. piston head; 134. transmission rod; 14. motor; 2. infusion module; 3. bubble monitoring module; 4. pressure monitoring module; 40. pressure plate; 400. chamber; 401. inlet; 402. outlet; 41. pressure cover; 42. strain gauge bridge; 43. circuit board; 44. card holder; 45. photoelectric trigger baffle; 46. photoelectric switch; 47. torsion spring; 48. waterproof cover; 5. air filter module; 6. pressure maintaining module; 7. Luer connector; 8. shell. DETAILED DESCRIPTION

[0030] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0031] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0032] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0033] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0034] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0035] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only implementation method.

[0036] Referring to Fig. 1, Fig. 1 shows a schematic diagram of the structure of a perfusion system in an embodiment of the present application. An embodiment of the present application provides a perfusion system, comprising a perfusion module 1, an infusion module 2, a bubble monitoring module 3, a pressure monitoring module 4 and a control module.

[0037] Specifically, the infusion module 2 includes a plurality of infusion pipelines, and an infusion channel is provided in the infusion pipeline for conveying liquid. The perfusion module 1 includes a liquid inlet end 10 and a liquid outlet end 11, wherein the liquid inlet end 10 is used to receive liquid from the infusion module 2, and the liquid outlet end 11 outputs the processed liquid to a target location such as a blood pump. The perfusion module 1 is connected in series in the infusion channel through the liquid inlet end 10 and the liquid outlet end 11. The bubble monitoring module 3 is arranged on the side of the perfusion module 1 close to the liquid inlet end 10, and a bubble detection sensor is integrated therein, which is used to monitor the bubbles in the liquid flowing into the liquid inlet end 10 through the infusion channel. The pressure monitoring module 4 is arranged on the side of the perfusion module 1 close to the liquid outlet end 11, and is connected to the liquid outlet end 11 through the infusion channel, and a pressure sensor is integrated therein, which is used to monitor the pressure of the liquid flowing out of the liquid outlet end 11. The control module is electrically connected to the bubble monitoring module 3 and the pressure monitoring module 4 respectively to ensure real-time transmission and processing of data.

[0038] During the perfusion process, the infusion module 2 delivers the liquid to the liquid inlet end 10 of the perfusion module 1 through the infusion channel. At the same time, the bubble detection sensor in the bubble monitoring module 3 starts to monitor in real time whether there are bubbles in the liquid. If bubbles with a volume greater than 5ul are detected, the sensor will immediately send a signal to the control module. After receiving the signal, the control module will analyze the number and size of the bubbles and determine whether it is necessary to trigger an alarm mechanism or take other protective measures based on a preset threshold or algorithm.

[0039] Furthermore, the pressure monitoring module 4 monitors in real time the pressure of the liquid flowing out of the liquid outlet 11 of the perfusion module 1. If the pressure exceeds a preset safety range, the control module will also receive an alarm signal and take corresponding protective measures.

[0040] As described above, the perfusion system realizes effective monitoring and control of bubbles and pressure during the perfusion process by integrating multiple functional modules such as the bubble monitoring module 3 and the pressure monitoring module 4, thereby ensuring the safety and stability of the perfusion process and providing a good treatment environment for patients; and the bubble detection sensor can detect bubbles with a volume greater than 5ul, and the response time is less than 200us, ensuring the accuracy and timeliness of bubble monitoring.

[0041] In one embodiment, the bubble detection sensor used in the bubble monitoring module 3 has high sensitivity, can detect bubbles with a volume greater than 5ul, and has an extremely short response time of less than 200us. The bubble detection sensor detects the presence of bubbles by monitoring optical or acoustic changes in the liquid. When bubbles enter the monitoring area, they change the optical or acoustic properties of the liquid, thereby triggering the response of the bubble detection sensor. The specific model and working principle of the bubble detection sensor are adaptively adjusted according to the use requirements, which will not be elaborated here.

[0042] In combination with Figures 2, 3 and 4, Figures 2, 3 and 4 are respectively a schematic diagram of the structure and an exploded diagram of a pressure monitoring module 4 provided in an embodiment of the present application. In some embodiments, the pressure monitoring module 4 includes a pressure plate 40, a pressure cover 41, a strain gauge bridge 42 and a circuit board 43.

[0043] Specifically, the pressure plate 40 is arranged on the side of the pressure cover 41 away from the strain gauge bridge 42, and one side of the pressure plate 40 is made of a flexible film, such as a flexible PVC film. The flexible PVC film has good elasticity and chemical stability, and can withstand the erosion of various liquids. The other side of the pressure plate 40 is a rigid structure, usually made of stainless steel or aluminum alloy, providing sufficient strength and stability. The two sides are tightly combined by ultrasonic welding technology to form a sealed internal liquid circuit.

[0044] Furthermore, the pressure plate 40 is communicated with the infusion channel, and the pressure plate 40 is used to transmit the pressure to the strain gauge bridge 42 through the pressure cover 41 .

[0045] In one embodiment, the pressure shield 41 is disposed on the side of the strain gauge bridge 42 away from the circuit board 43. The pressure shield 41 is a rigid shell whose shape and size match the strain gauge bridge 42 and is responsible for transmitting the pressure transmitted by the flexible membrane to the strain gauge bridge 42. In order to ensure the strength and durability of the pressure shield 41, it is usually made of high-strength materials such as stainless steel or aluminum alloy.

[0046] In one embodiment, the strain gauge bridge 42 is disposed on the circuit board 43, wherein the resistance element thereof will slightly deform when subjected to pressure. When the pressure shield 41 transmits the pressure to the strain gauge bridge 42, the resistance element in the bridge will deform, thereby causing a change in the resistance value, thereby reflecting the pressure change of the liquid in the liquid circuit.

[0047] In one embodiment, the circuit board 43 is the control center of the pressure monitoring module 4, which is responsible for providing a stable power supply to the strain gauge bridge 42, receiving, processing and transmitting the pressure signal from the strain gauge bridge 42, and outputting the pressure signal to the control module.

[0048] In the specific implementation process, when the perfusion liquid flows into the pressure disc 40 through the infusion channel, the liquid pressure acts on the flexible PVC film, causing the flexible film to expand and deform. Subsequently, the flexible film transmits this pressure change to the pressure cover 41, and finally transmits it to the strain gauge bridge 42 through the pressure cover 41. The strain gauge bridge 42 is deformed after being subjected to pressure, resulting in an unbalanced resistance value, thereby reflecting the pressure change of the liquid in the liquid circuit.

[0049] In one embodiment, the pressure plate 40 includes a chamber 400 .

[0050] Specifically, a chamber 400 is provided inside the pressure disc 40, and the chamber 400 is used to contain the liquid to be tested. A flexible membrane is arranged on one side of the chamber 400 near the pressure cover 41, and the flexible membrane has good elasticity and sealing performance, and can ensure that the liquid does not leak.

[0051] Furthermore, an inlet 401 and an outlet 402 connected to the infusion channel are respectively provided on both sides of the chamber 400. The inlet 401 is used to receive the infusion liquid, and the outlet 402 is used to discharge the liquid or maintain the flow of the liquid path. The inlet 401, the chamber 400 and the outlet 402 together form a liquid path, allowing the liquid to flow therein.

[0052] In a specific implementation process, when the perfusion liquid flows into the chamber 400 through the inlet 401, the liquid will fill the chamber 400 and squeeze the flexible membrane. Since the flexible membrane has good elasticity, it will expand and deform under the pressure of the liquid. The expansion and deformation of the flexible membrane will further squeeze the pressure cover 41, so that the pressure is transmitted to the strain bridge 42 through the pressure cover 41, causing the strain bridge 42 to deform slightly. By measuring the change in the resistance value in the strain bridge 42, the magnitude of the applied pressure can be calculated.

[0053] In this embodiment, the contact area between the flexible membrane and the pressure cover 41 is S, and the pressure of the liquid circuit in the pressure plate 40 is P. According to the pressure formula F=PS in physics, the pressure F on the strain gauge bridge 42 is calculated. In fact, when the liquid flows into the liquid circuit and squeezes the flexible membrane, the flexible membrane will completely transmit this pressure change to the pressure cover 41. Therefore, the pressure F on the strain gauge bridge 42 is equal to the product of the contact area S between the flexible membrane and the pressure cover 41 and the pressure P of the liquid circuit.

[0054] As described above, the precise measurement of liquid pressure is achieved through the structural design of the pressure plate 40, which has the advantages of simple structure and high measurement accuracy.

[0055] As shown in Figures 5 and 6, Figures 5 and 6 are respectively a schematic diagram of the structure and a schematic diagram of the cross section of the perfusion module 1 provided in an embodiment of the present application. In some embodiments, the perfusion system includes a housing 8, and the pressure monitoring module 4 includes a holder 44, which is disposed in the housing 8. The pressure disc 40 is firmly disposed in the holder 44 for easy disassembly and replacement.

[0056] In one embodiment, a waterproof cover 48 is provided outside the pressure cover 41 . The waterproof cover 48 can prevent the flexible membrane from being damaged and causing liquid to leak onto the strain gauge bridge 42 , thereby effectively improving the waterproof performance of the pressure monitoring module 4 .

[0057] In one embodiment, it also includes a photoelectric trigger baffle 45 , a photoelectric switch 46 and a torsion spring 47 .

[0058] Specifically, one end of the photoelectric trigger baffle 45 is electrically connected to the photoelectric switch 46, and the other end is in contact with the pressure plate 40. The torsion spring 47 is arranged at the connection between the photoelectric trigger baffle 45 and the holder 44. When the pressure plate 40 is installed in place, the photoelectric trigger circuit is disconnected by squeezing and pushing the photoelectric trigger baffle 45 away from the photoelectric switch 46, and it is considered that the pressure plate 40 is installed in place, thereby realizing intelligent detection of the installation state of the pressure plate 40. When the pressure plate 40 is not installed correctly or falls off, the torsion spring 47 resets the photoelectric trigger baffle 45 to connect with the photoelectric switch 46, so as to trigger the photoelectric switch 46 to send a reminder signal, which is convenient for the operator to handle in time.

[0059] Furthermore, the photoelectric trigger baffle 45 is movably disposed on the surface of the holder 44 through a fixing pin, the torsion spring 47 is sleeved on the fixing pin, and two ends of the torsion spring 47 are respectively embedded in the side walls of the holder 44 .

[0060] In one embodiment, the perfusion module 1 includes a perfusion box 12, a plunger pump 13 and a motor 14. The perfusion box 12 is installed in the housing 8, the perfusion box 12 includes a liquid inlet end 10 and a liquid outlet end 11, and the plunger pump 13 is disposed in the perfusion box 12.

[0061] Specifically, the liquid inlet 10 and the liquid outlet 11 of the perfusion box 12 are used for the suction and discharge of liquid. The motor 14 is used to drive the plunger pump 13 to move, so that the liquid flows into the liquid inlet 10 through the infusion channel and flows from the liquid outlet 11 to the pressure monitoring module 4, thereby controlling the flow of the liquid.

[0062] In this embodiment, the plunger pump 13 includes an inner tube 130 and an outer tube 131. The outer tube 131 is arranged on the side of the perfusion box 12 near the liquid outlet 11. One end of the outer tube 131 is provided with a liquid inlet 132. The liquid in the perfusion box 12 enters the outer tube 131 through the liquid inlet 132. A part of the inner tube 130 is arranged in the outer tube 131, and the other end extends out of the outer tube 131.

[0063] Furthermore, the plunger pump 13 also includes a piston head 133 and a transmission rod 134. The piston head 133 is connected to one end of the transmission rod 134. The piston head 133 is arranged in the inner tube 130. The other end of the transmission rod 134 is provided with a thread on the outside. The output end of the motor 14 is provided with a gear and a thread meshing transmission.

[0064] In a specific implementation process, the motor 14 rotates clockwise or counterclockwise, driving the transmission rod 134 to drive the piston head 133 to move, so that the volume between the piston head 133 and the inner tube 130 increases, generating negative pressure, thereby sucking the liquid in the perfusion box 12 into the inner tube 130 through the liquid inlet 132. The motor 14 rotates counterclockwise or clockwise, driving the transmission rod 134 to drive the piston head 133 to move, and the piston head 133 squeezes the liquid to flow out from the liquid outlet 11.

[0065] As shown in FIG. 1 , FIG. 1 is a schematic diagram of the structure of the perfusion system provided in an embodiment of the present application. In some embodiments, a bubble monitoring module 3 is provided between the liquid inlet 10 and the infusion channel to monitor in real time whether there are bubbles in the liquid, which helps prevent bubbles from entering the patient's body and improves the safety of the perfusion process. A pressure monitoring module 4 is provided between the liquid outlet 11 and another infusion channel to monitor in real time the liquid pressure during the perfusion process, which helps to determine whether there are bubbles or other abnormal conditions in the liquid and ensure the safety of the perfusion process.

[0066] In one embodiment, in order to detect whether the perfusion module 1 is installed in place, a perfusion box 12 detection module is also provided. When the perfusion module 1 is correctly installed, the perfusion box 12 detection module will send a signal to allow the motor 14 to start working, ensuring that the perfusion module 1 operates in a stable and reliable state.

[0067] In the specific implementation process, when the perfusion module 1 and the pressure monitoring module 4 are installed at the same time, the motor 14 will start to rotate rapidly clockwise / counterclockwise alternately, which helps to empty the gas in the perfusion pipeline and ensure the smooth progress of the perfusion process.

[0068] In one embodiment, the infusion module 2 includes a plurality of infusion pipelines, and an infusion channel is provided in the infusion pipeline. A one-way valve is provided between the liquid inlet end 10 and the infusion channel, and a one-way valve is also provided between the liquid outlet end 11 and the infusion channel, to ensure that the liquid can only flow in a predetermined direction, thereby preventing the backflow and cross contamination of the liquid.

[0069] In one embodiment, an air filter module 5 is further included. Specifically, the air filter module 5 is disposed at one end of the pressure monitoring module 4 away from the perfusion module 1, and the air filter module 5 is connected to the pressure monitoring module 4 through an infusion channel to filter out tiny bubbles and impurities in the liquid to ensure the purity of the perfusion liquid.

[0070] Furthermore, the air filter module 5 and the bubble detection sensor are mutually protected against single failures. When the bubble detection sensor fails, the air filter module 5 can still play a filtering role to prevent gas from entering the patient's body, thereby improving the safety and reliability of the perfusion system.

[0071] In one embodiment, the pressure maintaining module 6 is disposed at one end of the air filtering module 5 away from the pressure monitoring module 4, and the pressure maintaining module 6 is connected to the air filtering module 5 through an infusion channel. A large amount of perfusion liquid can be stored inside the pressure maintaining module 6, and pressure fluctuations can be absorbed and released to slow down the pressure change speed far from the liquid outlet end 11 of the perfusion module 1, thereby ensuring the stability and continuity of the perfusion process.

[0072] As described above, the purity and pressure stability of the perfusion liquid are both ensured through the design of the air filter module 5 and the pressure maintaining module 6. At the same time, the single fault protection measure improves the safety and reliability of the system.

[0073] According to another object of the present invention, a ventricular assist device is also provided. The ventricular assist device includes the perfusion system as described above, including a perfusion module 1, a bubble monitoring module 3, a pressure monitoring module 4, an air filtration module 5, and a pressure maintaining module 6. These modules are interconnected through an infusion channel to achieve precise control, real-time monitoring, and high safety assurance of the perfusion process. The perfusion system is connected to the ventricular assist device through a Luer connector 7.

[0074] In this embodiment, the perfusion system is connected to the catheter of the invasive left ventricular assist pump via the Luer connector 7, thereby achieving a close connection between the perfusion system and the ventricular assist device.

[0075] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0076] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A perfusion system, characterized in that: include: An infusion module (2), comprising an infusion channel; A perfusion module (1) comprising a liquid inlet end (10) and a liquid outlet end (11), wherein the perfusion module (1) is connected in series in the liquid infusion channel via the liquid inlet end (10) and the liquid outlet end (11); A bubble monitoring module (3) is arranged on a side of the perfusion module (1) close to the liquid inlet end (10) and is used to monitor bubbles in the liquid flowing into the liquid inlet end (10) through the infusion channel; a pressure monitoring module (4), arranged on a side of the perfusion module (1) close to the liquid outlet (11), connected to the liquid outlet (11) through the liquid infusion channel, and used for monitoring the pressure of liquid flowing out of the liquid outlet (11); The control module is electrically connected to the bubble monitoring module (3) and the pressure monitoring module (4) respectively.

2. The perfusion system according to claim 1, characterized in that The pressure monitoring module (4) comprises a pressure plate (40), a pressure cover (41), a strain gauge bridge (42) and a circuit board (43); the strain gauge bridge (42) is arranged on the circuit board (43); the pressure cover (41) is arranged on a side of the strain gauge bridge (42) away from the circuit board (43); and the pressure plate (40) is arranged on a side of the pressure cover (41) away from the strain gauge bridge (42); the pressure plate (40) is connected to the infusion channel, and the pressure plate (40) is used to transmit pressure to the strain gauge bridge (42) through the pressure cover (41).

3. The perfusion system according to claim 2, characterized in that The pressure disc (40) comprises a chamber (400) and a flexible membrane, wherein the flexible membrane is arranged on a side of the chamber (400) close to the pressure shield (41); an inlet (401) and an outlet (402) connected to the infusion channel are respectively arranged on both sides of the chamber (400); when the perfusion liquid flows through the chamber (400), the flexible membrane expands and squeezes the pressure shield (41).

4. The perfusion system according to claim 2, characterized in that The perfusion system comprises a housing (8), the pressure monitoring module (4) comprises a card seat (44), the card seat (44) is arranged in the housing (8), and the pressure disc (40) is connected to the card seat (44).

5. The perfusion system according to claim 4, characterized in that The pressure monitoring module (4) further comprises a photoelectric trigger baffle (45), a photoelectric switch (46) and a torsion spring (47); the photoelectric switch (46) is arranged on the circuit board (43); one end of the photoelectric trigger baffle (45) is electrically connected to the photoelectric switch (46), and the other end is in contact with the pressure plate (40); the photoelectric trigger baffle (45) is movably arranged on the surface of the holder (44) through a fixing pin; the torsion spring (47) is sleeved on the fixing pin; and the two ends of the torsion spring (47) are respectively embedded in the side walls of the holder (44).

6. The perfusion system according to any one of claims 1 to 5, characterized in that: The perfusion module (1) comprises a perfusion box (12), a plunger pump (13) and a motor (14); the perfusion box (12) comprises a liquid inlet end (10) and a liquid outlet end (11); the plunger pump (13) is arranged in the perfusion box (12); and the motor (14) is used for driving the plunger pump (13) to move.

7. The perfusion system according to any one of claims 1 to 5, characterized in that: One-way valves are respectively arranged between the infusion channel and the liquid inlet end (10), and between the liquid outlet end (11) and the infusion channel.

8. The perfusion system according to any one of claims 1 to 5, characterized in that: The perfusion system further comprises an air filtering module (5), wherein the air filtering module (5) is arranged at an end of the pressure monitoring module (4) away from the perfusion module (1), and the air filtering module (5) is connected to the pressure monitoring module (4) through the infusion channel.

9. The perfusion system according to claim 8, characterized in that The perfusion system further comprises a pressure maintaining module (6), wherein the pressure maintaining module (6) is arranged at one end of the air filtering module (5) away from the pressure monitoring module (4), and the pressure maintaining module (6) is connected to the air filtering module (5) via the infusion channel.

10. A ventricular assist device, characterized in that: Comprising a perfusion system as described in any one of claims 1-9; the perfusion system is connected to a ventricular assist device.

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