Traditional Chinese medicine composition for treating gouty arthritis, ointment and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating gouty arthritis, ointment and a preparation method thereof, and relates to the field of medicines. The ointment for treating gouty arthritis is prepared from the following medicinal materials in parts by weight: 20 to 25 parts of rhizoma curcumae longae, 20 to 25 parts of radix et rhizoma rhei, 20 to 25 parts of cortex phellodendri, 10 to 15 parts of liquorice root, 10 to 15 parts of arisaema cum bile, 20 to 25 parts of radix angelicae dahuricae, 10 to 15 parts of rhizoma smilacis glabrae, 10 to 15 parts of vinegar frankincense, 10 to 15 parts of vinegar myrrh, 10 to 15 parts of fructus gardeniae, 4 to 6 parts of radix aconiti, 10 to 15 parts of herba portulacae and 4 to 6 parts of radix aconiti agrestis. The rhubarb is used as a monarch drug, has the effects of clearing heat, purging fire, dissipating carbuncle swelling, bitter cold, clearing heat, clearing heat, purging fire, removing toxin, activating blood, removing stasis, diminishing swelling, relaxing bowel and conducting heat; angelica dahurica, turmeric, golden cypress, purslane and cape jasmine are used as ministerial drugs to assist the monarch drugs in dispersing blood stasis, relieving pain, detoxifying and diminishing swelling; arisaema cum bile, rhizoma smilacis glabrae, frankincense, myrrh, radix aconiti, radix aconiti agrestis and the like are used as adjuvant drugs for warming dryness, promoting qi to activate blood and helping monarch and ministerial drugs to dissipate stagnation, relieve swelling and relieve pain; the liquorice is a conductant drug; the clinical curative effect on gouty arthritis is good.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, and in particular to a traditional Chinese medicine composition and an ointment for treating gouty arthritis and a preparation method thereof. Background Art

[0002] At present, there are about 12.1 million heart failure patients in my country, and about 3 million new heart failure patients are added each year. Due to the prevalence of heart failure-related risk factors and the increasing aging of the population, it is expected that the burden of heart failure in my country will continue to rise in the future.

[0003] A series of physiological changes caused by heart failure affect the metabolism and excretion of uric acid. 1. In heart failure, the heart's contraction and relaxation functions decline, and it cannot effectively pump blood, resulting in a decrease in renal blood flow. The kidney is the main organ for uric acid excretion. When the kidney blood perfusion is insufficient, the excretion of uric acid will be affected, which will cause an increase in blood uric acid levels. Long-term hyperuricemia will increase the risk of urate crystals deposited in joints and other tissues, thereby inducing gout. 2. Renal insufficiency: Some patients with heart failure may have renal insufficiency, which is caused by the weakening of the heart's pumping function, resulting in insufficient renal perfusion and decreased glomerular filtration rate. Renal insufficiency will further reduce the excretion of uric acid and increase the risk of hyperuricemia and gout. 3. Edema and metabolic disorders: Patients with heart failure often experience symptoms of edema, which is due to the weakening of the heart's pumping ability, and the reflux of fluid to the periphery leads to the accumulation of water in the body's tissue spaces. In the state of edema, urate crystals are more likely to deposit in joints and other tissues, inducing gout attacks. In addition, in order to meet the needs of important organs during heart failure, the body will increase heart rate and blood pressure, leading to faster metabolism, more uric acid production, and further aggravating metabolic disorders. 4. Side effects of drugs: Among the drugs used to treat heart failure, certain diuretics (such as thiazide diuretics) may reduce the excretion of uric acid, leading to increased blood uric acid levels. In addition, other drugs (such as certain antihypertensive drugs and immunosuppressants) may also affect uric acid metabolism and increase the risk of gout. 5. Lifestyle factors: Due to the limitations of their condition, patients with heart failure may have reduced activity and weight gain, which can also increase the risk of gout. At the same time, poor eating habits (such as a high-purine diet) can also aggravate hyperuricemia and gout.

[0004] Data show that the prevalence of hyperuricemia in patients with heart failure is as high as 50%, which leads to repeated attacks of gouty arthritis and increases the physical and psychological burden on patients. Hyperuricemia is associated with a poor prognosis of heart failure, and uric acid-lowering therapy is beneficial for patients with heart failure. How to apply the characteristics of traditional Chinese medicine to relieve gouty arthritis caused by hyperuricemia in patients with heart failure is the original purpose of our research and development of gout ointment. Summary of the invention

[0005] In view of this, the present invention provides an ointment for treating gouty arthritis and a preparation method thereof.

[0006] Gout should follow the principle of taking both the symptoms and the root cause into consideration. In the acute stage, the main treatment is to treat the pathogenic factors, and the treatment is to clear away heat, dissipate turbidity and resolve blood stasis, and to control the symptoms of redness, swelling, heat and pain in the joints. The cold, heat, deficiency and excess, the rise and fall of the pathogenic factors and the righteous factors should be distinguished, and the prescription should be used. In the remission stage, the main treatment is to treat the root cause, and the treatment is to tonify the spleen, dry dampness and dissipate turbidity, support the righteousness, and expel the pathogenic factors. The prescription developed this time is related to the acute attack of gout, which is manifested as sudden redness, swelling and pain in a single toe joint, and gradually severe pain like a tiger bite, mild during the day and severe at night, and repeated attacks, which may be accompanied by fever, headache and other symptoms, which seriously affect the quality of life of patients. According to the theory of traditional Chinese medicine, the occurrence of gout is related to factors such as insufficient righteousness in the human body, exogenous rheumatic heat or endogenous phlegm and blood stasis. According to different clinical manifestations, it can be divided into damp-heat accumulation, cold-dampness and arthralgia, spleen deficiency and dampness, spleen and kidney deficiency, and phlegm-dampness and blood stasis. Patients with acute gout attacks are mainly characterized by damp-heat accumulation. Damp-heat accumulation syndrome is a common clinical disease. It is mainly caused by external pathogens, improper diet, spleen dysfunction, emotional frustration, direct invasion of damp-heat evil, or due to weak spleen and stomach, weak yang, poor fluid circulation, endogenous damp-heat evil, accumulation for a long time, damp-heat betting, blocking the meridians and blood, meridian stasis, pain due to blockage, and gout. Patients with heart failure and gout attacks are all weak in the root and strong in the symptoms, and the latter is the main pathogenesis. We have developed an external treatment prescription for this type of patients. The treatment of damp-heat syndrome is based on the principle of removing dampness and clearing heat. Since the symptoms caused by damp-heat pathogens have the dual nature of dampness and heat, dampness and heat must be treated simultaneously. In the Treatise on Warm Diseases by Wu Jutong of the Qing Dynasty, it is pointed out that "clearing away heat will not reduce dampness, and removing dampness will only make the heat more intense." In terms of specific treatment methods, it is necessary to flexibly apply them according to the severity of dampness and heat, the location, and the deficiency and excess of the symptoms. In the treatment of dampness and heat syndrome, attention should also be paid to the mechanism of dispersing qi. Dampness is sticky and easy to block the mechanism of qi. Dampness blocks qi stagnation, and qi stagnation aggravates dampness. At the same time, avoid large doses of bitter and cold medicines. Large doses of bitter and cold products can easily damage yang qi, or ice dampness and heat, which often only alleviates symptoms. In fact, dampness and heat evils are more difficult to eliminate. "Clinical Guide Medical Cases" points out that "Taiyin damp soil begins to move with yang, and Yangming dry soil is at ease with yin." It puts forward the argument of "slightly bitter to clear and descend, and slightly pungent to spread and unblock", pointing out that "pungent can unblock yang, bitter can clear and descend", and pungent and pungent can be used together, so "bitter and cold can clear heat and remove dampness, and pungent can open qi and eliminate turbidity". "Warm and Hot Theory" says: "And the dampness in Wu harms the most people. For example, if the face is pale, we need to take care of the yang qi. If the dampness prevails, the yang qi will be weak." During treatment, appropriate warming yang products are added to warm the yang qi of the human body and replenish the damaged yang qi. As long as the yang qi is spread, the dampness evil can be quickly transformed. When the dampness is gone, the heat is isolated and the heat is cleared quickly. Even if the evil heat is temporarily warm and intense, it is better to be hot than cold. It is easier to clear heat when the dampness is gone. The homemade gout ointment is mainly composed of clearing heat, removing dampness, warming yang and relieving pain. When gout arthritis attacks, because the dampness is sticky, it is difficult to remove dampness and easy to remove heat compared to the heat evil, so warming yang products are added to the prescription to enhance the effect of removing dampness.

[0007] The technical solution of the present invention is achieved in this way:

[0008] A plaster for treating gouty arthritis comprises the following medicinal materials by weight: 20-25 parts of turmeric, 20-25 parts of rhubarb, 20-25 parts of phellodendron, 10-15 parts of liquorice, 10-15 parts of arisaema ciliata, 20-25 parts of angelica dahurica, 10-15 parts of smilax glabra, 10-15 parts of vinegar frankincense, 10-15 parts of vinegar myrrh, 10-15 parts of gardenia, 4-6 parts of aconite, 10-15 parts of purslane and 4-6 parts of aconite.

[0009] A further technical solution is that it also includes the following medicinal materials: atractylodes, magnolia bark, and tangerine peel. The ointment includes the following medicinal materials by weight: 20-25 parts of turmeric, 20-25 parts of rhubarb, 20-25 parts of phellodendron, 10-15 parts of atractylodes, 10-15 parts of magnolia bark, 10-15 parts of tangerine peel, 10-15 parts of licorice, 10-15 parts of arisaema, 20-25 parts of angelica, 10-15 parts of smilax glabra, 10-15 parts of vinegar frankincense, 10-15 parts of vinegar myrrh, 10-15 parts of gardenia, 4-6 parts of Chuanwu, 10-15 parts of purslane, and 4-6 parts of Aconitum kusnezoffii.

[0010] A further technical solution is that, by weight, it includes the following medicinal materials: 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh, 10 parts of gardenia, 5 parts of Chuanwu, 10 parts of purslane, and 5 parts of Aconitum kusnezoffii.

[0011] The present invention also provides a method for preparing an ointment for treating gouty arthritis, comprising the following steps: taking medicinal materials according to a formula, crushing them into powder, heating vaseline in water to melt it into a liquid state, adding the powder and stirring evenly, and allowing the liquid medicine to stand and solidify into a paste to obtain the ointment.

[0012] A further technical solution is that the powder has a mesh size of 300-600.

[0013] A further technical solution is that the mass volume ratio of the medicinal material to vaseline is 200-250 g / ml:500-800.

[0014] A further technical solution is that the mass volume ratio of the medicinal material to vaseline is 210:500 g / ml.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The present invention uses rhubarb as the main drug, which plays the role of clearing away heat, purging fire, and dissipating carbuncle. It is bitter and cold and clears heat, clears heat, purges fire and detoxifies, and can promote blood circulation, remove blood stasis and reduce swelling, and can attack the lower part and relieve constipation, and conduct heat out; Angelica dahurica, turmeric, phellodendron, purslane and gardenia are used as assistant drugs, which assist the main drug in removing blood stasis and relieving pain, detoxifying and reducing swelling; Angelica dahurica is pungent, fragrant and warm, and can go through the skin to reduce swelling and discharge pus to treat sores; turmeric is pungent, dispersing, bitter, purging, warming and unblocking, and is good at promoting blood circulation, promoting qi, reducing swelling and relieving pain; phellodendron is bitter and cold and clears, and is good at purging fire, detoxifying and drying dampness; purslane is cold in nature and flavor, clears heat and detoxifies, promotes diuresis and removes dampness, reduces swelling, reduces inflammation and relieves pain; gardenia is bitter and cold, is good at relieving the fire of the three burners, clears heat, clears heat and detoxifies, reduces swelling and relieves pain; Atractylodes lancea, Magnolia bark, Chen The peel, gallbladder arisaema, smilax glabra, frankincense, myrrh, Chuanwu and Caowu are used as adjuvants, warming and drying, promoting qi and blood circulation, and helping the monarch and ministerial drugs to dissipate stagnation, reduce swelling and relieve pain; Atractylodes lancea is pungent, warm and dry, good at drying dampness; Magnolia officinalis is bitter, pungent, dry, dispersing, warming and unblocking, good at promoting qi and drying dampness; Tangerine peel is pungent, dispersing, bitter, dry, warming and unblocking, good at promoting qi and relieving pain; Raw arisaema is bitter, dry, pungent and dispersing, warming and toxic, good at drying dampness and resolving phlegm, dispersing stagnation and reducing swelling; Tusmilax glabra has a sweet and mild medicinal property, which has the effects of detoxifying and removing dampness, reducing swelling and dispersing stagnation, and unblocking joints; frankincense and myrrh are pungent and warm products that dredge meridians, promote blood circulation and remove blood stasis, reduce swelling and relieve pain, and help remove dampness and promote diuresis; Chuanwu and Caowu are hot in nature, pungent in taste, belong to the liver, spleen and kidney meridians, and warm the yang to help promote diuresis and remove dampness, relieve urgency and relieve pain. Licorice is used as a messenger, sweet and flat, detoxifying, and harmonizing medicinal properties; the prescriptions of various medicines have significant therapeutic effects in treating gouty arthritis (heart failure with pain and arthralgia). DETAILED DESCRIPTION

[0017] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0018] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0019] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0020] Example 1

[0021] Chinese medicine formula: by weight, 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh, 10 parts of gardenia, 5 parts of Chuanwu, 10 parts of Portulaca oleracea, and 5 parts of Aconitum.

[0022] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0023] Example 2

[0024] Chinese medicine formula: by weight, 20 parts of turmeric, 20 parts of rhubarb, 20 parts of phellodendron, 15 parts of atractylodes, 15 parts of magnolia bark, 15 parts of tangerine peel, 15 parts of licorice, 15 parts of arisaema, 20 parts of angelica, 15 parts of smilax glabra, 15 parts of vinegar frankincense, 15 parts of vinegar myrrh, 15 parts of gardenia, 4 parts of Chuanwu, 15 parts of purslane, and 6 parts of Aconitum.

[0025] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0026] Example 3

[0027] Chinese medicine formula: by weight, 20 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 20 parts of angelica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh, 15 parts of gardenia, 5 parts of aconite, 15 parts of purslane, and 5 parts of aconite.

[0028] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0029] Comparative Example 1

[0030] The difference from Example 1 is that purslane and gardenia are not contained.

[0031] Chinese medicine formula: by weight, 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh, 5 parts of aconite, and 5 parts of kusnezoffii.

[0032] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0033] Comparative Example 2

[0034] The difference from Example 1 is that it does not contain Rhizoma Smilacis Glabrae, Vinegar Frankincense and Rhizoma Aconiti Lateralis.

[0035] Chinese medicine formula: by weight, 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica, 10 parts of myrrh, 10 parts of gardenia, 10 parts of purslane, and 5 parts of aconite.

[0036] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0037] Comparative Example 3

[0038] The difference from Example 1 is that Myrrha and Aconite are not contained.

[0039] Chinese medicine formula: by weight, 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of gardenia, 5 parts of aconite, and 10 parts of purslane.

[0040] Preparation method: The Chinese medicine formula is made into powder (300-600 mesh); after the vaseline is heated in water to melt into liquid, the Chinese medicine formula powder is added and stirred evenly, the powder and vaseline liquid ratio g / ml is 1:2.38, and the liquid is allowed to stand to solidify into a paste.

[0041] Clinical observation

[0042] 1 General data: 200 patients with acute gouty arthritis (AGA), aged 50 to 87 years old, with a male ratio of about 65%, were randomly divided into 4 groups. There was no statistically significant difference in the general data of the patients in each group, and they were comparable.

[0043] 2 Diagnostic criteria: Western medicine standards: in line with the ACR / EULAR acute gouty arthritis classification criteria; Traditional Chinese medicine standards: in line with the gout classification criteria of the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases and Syndromes".

[0044] 3 Inclusion criteria: Patients met the above-mentioned diagnostic criteria of traditional Chinese and Western medicine, AGA was in the acute stage, and the acute onset time was <72h; and the patients had been previously diagnosed with heart failure and accompanied by hyperuricemia.

[0045] Exclusion criteria: (1) patients with allergic constitution; (2) pregnant or lactating women; (3) patients with a history of other serious complications or tumors; (4) patients with mental or psychological abnormalities; (5) patients with joint deformity, disability, or local skin damage; (6) patients participating in other clinical drug trials.

[0046] 4 Methods: Experimental groups 1 to 4 were treated with the Chinese medicine ointments of Example 1 and Comparative Examples 1-3 respectively. Usage: Apply to the affected area (applying thickness of about 1 mm), twice a day. The course of treatment was 1 week. The number of tender joints, swollen joints, and painful joints before and after treatment were observed, and the VAS (visual analogue of pain) score was recorded.

[0047] 5. Efficacy judgment criteria: refer to the gout disease efficacy judgment criteria in the "Chinese Medicine Disease Diagnosis and Efficacy Criteria"

[0048] Clinical cure: symptoms and signs disappear or almost disappear, and the TCM syndrome score decreases by ≥95%.

[0049] Markedly effective: symptoms and signs were significantly improved, with TCM syndrome scores reduced by 70%≤<95%.

[0050] Effective: Symptoms and signs improved, with TCM syndrome score reduced by 30%≤<70%.

[0051] Ineffective: symptoms and signs worsen or do not improve, and the TCM syndrome score decreases by <30%.

[0052] 6 Treatment Outcomes

[0053]

[0054] The results showed that the ointment of Example 1 of the present invention had a good therapeutic effect on the treatment of acute gouty arthritis, with a clinical cure rate of 76%, a marked effect rate of 88%, and a total effective rate of 98%. However, the therapeutic effects of Comparative Examples 1-3 were poor, especially the number of clinically cured cases decreased significantly.

[0055] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating gouty arthritis, characterized in that: The invention comprises the following medicinal materials by weight: 20-25 parts of turmeric, 20-25 parts of rhubarb, 20-25 parts of phellodendron, 10-15 parts of licorice, 10-15 parts of arisaema, 20-25 parts of angelica dahurica, 10-15 parts of smilax glabra, 10-15 parts of vinegar frankincense, 10-15 parts of vinegar myrrh, 10-15 parts of gardenia, 4-6 parts of aconite, 10-15 parts of purslane and 4-6 parts of aconite.

2. A Chinese medicine composition for treating gouty arthritis according to claim 1, characterized in that: It also includes the following medicinal materials: atractylodes, magnolia bark, and tangerine peel. The ointment includes the following medicinal materials by weight: 20-25 parts of turmeric, 20-25 parts of rhubarb, 20-25 parts of phellodendron, 10-15 parts of atractylodes, 10-15 parts of magnolia bark, 10-15 parts of tangerine peel, 10-15 parts of licorice, 10-15 parts of arisaema, 20-25 parts of angelica, 10-15 parts of smilax glabra, 10-15 parts of vinegar frankincense, 10-15 parts of vinegar myrrh, 10-15 parts of gardenia, 4-6 parts of aconite, 10-15 parts of purslane, and 4-6 parts of aconite.

3. A Chinese medicine composition for treating gouty arthritis according to claim 2, characterized in that: The invention comprises the following medicinal materials by weight: 25 parts of turmeric, 25 parts of rhubarb, 25 parts of phellodendron, 10 parts of atractylodes, 10 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of licorice, 10 parts of arisaema, 25 parts of angelica dahurica, 10 parts of smilax glabra, 10 parts of vinegar frankincense, 10 parts of vinegar myrrh, 10 parts of gardenia, 5 parts of aconite, 10 parts of purslane and 5 parts of aconite.

4. An ointment for treating gouty arthritis, characterized in that: Prepared from the Chinese medicine composition according to any one of claims 1, 2 or 3.

5. The method for preparing the ointment for treating gouty arthritis according to claim 4, characterized in that: The method comprises the following steps: taking medicinal materials according to the formula, crushing them into powder, heating vaseline in water to melt it into liquid, adding the powder and stirring evenly, and letting the medicinal liquid stand to solidify into a paste to prepare the ointment.

6. The method for preparing a plaster for treating gouty arthritis according to claim 5, characterized in that: The powder is 300-600 mesh.

7. A method for preparing an ointment for treating gouty arthritis according to claim 5 or 6, characterized in that: The mass volume ratio of the medicinal material to vaseline is 200-250 g / ml:500-800.

8. The method for preparing a plaster for treating gouty arthritis according to claim 7, characterized in that: The mass volume ratio of medicinal materials to vaseline is 210:500 g / ml.

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