Sample analyzer and control method of ultrasonic device thereof

Abstract

The invention is suitable for the field of in vitro diagnostic equipment, and discloses a sample analyzer and a control method of an ultrasonic transducer. A control device of the sample analyzer is configured to control an ultrasonic transducer to execute frequency locking operation in a uniform mixing period of a target liquid, and before a preset condition is not met, if the driving frequency of the ultrasonic transducer is adjusted to exceed a first preset frequency range, the target liquid is subjected to frequency locking operation; if yes, judging whether the accumulated parameter of the frequency locking operation in the single mixing period is greater than or equal to a first preset value or whether the remaining parameter capable of performing the frequency locking operation in the single mixing period is smaller than a second preset value or whether the remaining duration in the single mixing period is smaller than or equal to a third preset value, and if yes, judging that the frequency locking fails; and if not, restarting the ultrasonic transducer to carry out frequency locking operation again. The frequency locking success rate is increased through multiple times of frequency locking in the uniform mixing period, and unnecessary waste of samples and reagents is reduced.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic equipment, and in particular to a sample analyzer and a control method for an ultrasonic device in the sample analyzer. Background Art

[0002] A sample analyzer provided by the related technology is provided with an ultrasonic device for ultrasonically mixing a mixed liquid containing at least a sample and a reagent. In order for the mixed liquid to achieve the desired mixing effect under the action of ultrasound, a control device with a frequency locking function is required to control the ultrasonic device to operate at its resonant frequency. In order to realize the automatic measurement function of the sample, the sample analyzer needs to impose timing restrictions on the operation of each device. In terms of frequency locking design, the related technology adopts a phase-locked loop technology with a shorter frequency locking time to reserve sufficient time for stable ultrasonic mixing operations. The stable ultrasonic mixing time after successful frequency locking may have different time requirements depending on different measurement items. However, frequency locking failure is an unacceptable situation in this scenario. An unmixed mixed liquid will lead to inaccurate measurement results, and frequency locking failure cannot be avoided under the influence of external environmental factors such as the liquid properties of the mixed liquid.

[0003] In a single mixing cycle of the related art, a single frequency locking control method is used, that is, if the single frequency locking does not meet the preset conditions in a single mixing cycle, the frequency locking is determined to have failed, and the sample and reagent are discarded for retesting. This solution will cause waste of samples and reagents, and reduce the measurement throughput of the sample analyzer. Summary of the invention

[0004] The first object of the present invention is to provide a sample analyzer, which aims to solve the technical problems in the design solutions in the related art that the design solutions easily cause unnecessary waste of samples and reagents and low measurement throughput.

[0005] To achieve the above object, the present invention provides a solution: a sample analyzer, comprising:

[0006] A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container;

[0007] A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container;

[0008] An ultrasonic device, the ultrasonic device comprising a device for ultrasonically mixing a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent;

[0009] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0010] A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing period of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device; if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and perform the step of determining whether the preset condition is met according to the working parameters fed back by the ultrasonic device, until the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range;

[0011] The control device is also configured to perform the following operations within the mixing cycle of the target liquid: before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, determine whether the cumulative parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value or whether the remaining time within the single mixing cycle is less than or equal to the third preset value; if so, determine that the frequency locking has failed; if not, restart the ultrasonic device to perform the frequency locking operation again.

[0012] As an implementation manner, whether the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset duration.

[0013] As an embodiment, the control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid;

[0014] The first preset duration is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

[0015] As an implementation manner, whether the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset value includes: whether the accumulated number of the frequency locking operation in a single mixing cycle is greater than or equal to a preset number.

[0016] As an embodiment, the control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid;

[0017] The product of the preset number of times and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

[0018] As an implementation manner, whether the parameter remaining for the frequency locking operation in a single mixing cycle is less than a second preset value includes: in a single mixing cycle, the remaining duration for the frequency locking operation is less than the duration required for a single frequency locking operation; or,

[0019] Whether the remaining parameters for the frequency locking operation in a single mixing cycle are less than a second preset value includes: in a single mixing cycle, the remaining number of times the frequency locking operation can be performed is less than one; or,

[0020] Whether the remaining time in a single mixing cycle is less than a third preset value includes: within a single mixing cycle, the remaining time is less than a second preset time, and the second preset time is a preset time during the mixing cycle and after it is determined that the frequency is locked successfully, and the ultrasonic device is driven to work according to the driving frequency when the frequency is locked successfully to perform ultrasonic mixing on the target liquid.

[0021] As an implementation manner, the first preset value or the second preset value is determined by a measurement item corresponding to the target liquid.

[0022] As an embodiment, the preset condition includes that the driving frequency of the ultrasonic device is within a first preset range of the resonant frequency; and / or,

[0023] The preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device is within a second preset range.

[0024] As an embodiment, the ultrasonic device includes an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer;

[0025] The driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to the ultrasonic mixing position, so that the ultrasonic vibrator ultrasonically mixes the target liquid at the ultrasonic mixing position;

[0026] The control device is further configured to: before controlling the ultrasonic transducer to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position.

[0027] As an embodiment, the ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing.

[0028] As an implementation manner, the ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

[0029] As an embodiment, the control device is further configured to: if it is determined that the frequency locking fails, cancel the ultrasonic mixing operation on the target liquid, and re-measure the measurement items corresponding to the target liquid; or,

[0030] The control device is further configured to: if it is determined that the frequency locking fails, continue to perform the ultrasonic mixing operation on the target liquid, continue to execute the measurement items corresponding to the target liquid, and add a mark to the measurement result corresponding to the target liquid.

[0031] As an embodiment, the control device is further configured to adjust the driving frequency of the ultrasonic device in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency.

[0032] A second object of the present invention is to provide a sample analyzer, the sample analyzer comprising:

[0033] A sample dispensing device, the sample dispensing device comprising a sample needle, the sample needle being used to draw a sample from a sample container and to distribute at least a portion of the drawn sample to a reaction container;

[0034] A reagent dispensing device, the reagent dispensing device comprising a reagent needle, the reagent needle being used to draw a reagent from a reagent container and to dispense at least a portion of the drawn reagent into the reaction container;

[0035] a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod;

[0036] An ultrasonic device, the ultrasonic device is used to transmit ultrasonic waves to a target liquid, the target liquid being one of the sample, the reagent, the cleaning liquid, and a mixed liquid at least containing the sample and the reagent;

[0037] a measuring device for measuring a reaction solution made of at least a mixed solution;

[0038] A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and perform the step of determining whether the preset condition is met according to the working parameters fed back by the ultrasonic device, until the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range;

[0039] The control device is also configured to perform the following operations within the ultrasonic working cycle of the target liquid: before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, determine whether the cumulative parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value or whether the remaining time within the single mixing cycle is less than or equal to the third preset value; if so, determine that the frequency locking has failed; if not, restart the ultrasonic device to perform the frequency locking operation again.

[0040] As an embodiment, the control device is also configured to: within the ultrasonic working cycle, and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid.

[0041] Wherein, whether the accumulated parameter of the frequency locking operation in a single ultrasonic working cycle is greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation in a single ultrasonic working cycle is greater than or equal to a first preset duration, wherein the first preset duration is less than or equal to the difference between the duration of the ultrasonic working cycle and the second preset duration; or,

[0042] Whether the cumulative parameters of the frequency locking operation within a single ultrasonic working cycle are greater than or equal to a first preset value includes: within a single ultrasonic working cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the ultrasonic working cycle and the second preset duration.

[0043] A third object of the present invention is to provide a method for controlling an ultrasonic device in a sample analyzer, the method comprising the following steps:

[0044] Controlling the ultrasonic device to start, judging whether a preset condition is met according to the working parameters fed back by the ultrasonic device, and if so, determining that the frequency locking is successful and stopping the frequency locking operation; if not, adjusting the driving frequency of the ultrasonic device, and executing the step of judging whether the preset condition is met according to the working parameters fed back by the ultrasonic device until the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range;

[0045] Before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, it is determined whether the accumulated parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value, or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value, or whether the remaining time within the single mixing cycle is less than or equal to the third preset value. If so, it is determined that the frequency locking has failed; if not, the ultrasonic device is restarted to perform the frequency locking operation again.

[0046] As an embodiment, the control method further includes: within the mixing cycle and after determining that the frequency locking is successful, driving the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to drive the ultrasonic vibrator to ultrasonically mix the target liquid;

[0047] Wherein, whether the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset duration, wherein the first preset duration is less than or equal to the difference between the duration of the mixing cycle and the second preset duration; or,

[0048] Whether the cumulative parameters of the frequency locking operation within a single mixing cycle are greater than or equal to a first preset value includes: within a single mixing cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

[0049] The sample analyzer and the control method of the ultrasonic device in the sample analyzer provided by the present invention, in a single mixing cycle, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range before the frequency locking operation meets the preset conditions, then further according to the accumulated parameters of the frequency locking operation in the single mixing cycle or the parameters remaining for the frequency locking operation in the single mixing cycle or the remaining time in the single mixing cycle, it is judged whether the frequency locking fails or the ultrasonic device can be restarted to perform the frequency locking operation again, so that under the timing limit of the mixing cycle of the sample analyzer, combined with the single frequency locking control logic, when the single frequency locking does not meet the preset conditions, the frequency locking success rate in the mixing cycle can be improved by performing two or more frequency locking operations, thereby avoiding unnecessary waste of samples and reagents and facilitating improving the measurement throughput of the sample analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0051] Figure 1 is a schematic diagram of the composition of a sample analyzer provided in Embodiment 1 of the present invention;

[0052] Figure 2 is a structural schematic diagram of a sample analyzer provided in Embodiment 1 of the present invention;

[0053] Figure 3 is a schematic diagram of ultrasonic mixing of a target liquid by an ultrasonic device provided in Embodiment 1 of the present invention;

[0054] Figure 4 is a schematic diagram of the composition of the control device provided in Embodiment 1 of the present invention;

[0055] Figure 5 is a flow chart of a control method of an ultrasonic device provided in Embodiment 1 of the present invention;

[0056] Figure 6 It is a flow chart of a control method of an ultrasonic device provided in Embodiment 3 of the present invention.

[0057] Explanation of the accompanying drawings: 10. Sample analyzer; 100. Ultrasonic device; 110. Ultrasonic transducer; 111. Piezoelectric ceramic component; 120. Ultrasonic vibrator; 200. Control device; 210. Ultrasonic control board; 220. Main control board; 300. Sample dispensing device; 400. Reagent dispensing device; 500. Measurement device; 600. Reagent loading device; 700. Incubation device; 800. Transfer device; 900. Reaction container providing device; 101. Sample management device; 102. Sample transport device; 103. Magnetic separation device; 20. Target liquid; 30. Reaction container. DETAILED DESCRIPTION

[0058] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0059] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back, etc.) are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0060] It should also be noted that when an element is referred to as being "fixed on" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or may be indirectly connected to the other element through an intermediate element.

[0061] In addition, the descriptions of "first", "second", etc. in the present invention are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0062] Embodiment 1:

[0063] like Figures 1 to 5As shown, the sample analyzer 10 provided in the first embodiment of the present invention includes an ultrasonic device 100, and the ultrasonic device 100 is used to ultrasonically mix the target liquid 20, and the target liquid 20 is one of a sample, a reagent, and a mixed liquid containing at least a sample and a reagent. The ultrasonic device 100 achieves the effect of mixing the target liquid 20 by transmitting ultrasonic waves to the target liquid 20. The use of the ultrasonic device 100 to mix the target liquid 20 has the characteristic of high mixing efficiency, which is conducive to improving the sample measurement efficiency of the sample analyzer 10.

[0064] As an embodiment, the sample analyzer 10 also includes a control device 200, which is configured to control the ultrasonic device 100 to perform a frequency locking operation during the mixing period of the target liquid 20. After the frequency locking is successful, the control device 200 is also configured to control the ultrasonic device 100 to perform an ultrasonic mixing operation on the target liquid 20 during the mixing period of the target liquid 20. The frequency locking operation is mainly used to determine the target driving frequency of the ultrasonic device 100, so that in the ultrasonic mixing operation, the ultrasonic device 100 is driven at the target driving frequency to transmit ultrasonic waves to the target liquid 20, thereby ensuring the effect of ultrasonic mixing. Among them, the target driving frequency is used to characterize that the ultrasonic device 100 operates within a preset range of the resonant frequency. The electromechanical conversion efficiency is highest when the ultrasonic device 100 operates at its resonant frequency.

[0065] As an embodiment, the control device 200 is configured to control the ultrasonic device 100 to perform the following frequency locking operation during the mixing cycle of the target liquid 20: control the ultrasonic device 100 to start and judge whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100. If yes, the frequency locking is determined to be successful and the frequency locking operation is stopped; if not, the driving frequency of the ultrasonic device 100 is adjusted, and the step of judging whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100 is performed until the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range. The frequency locking operation here is a single frequency locking operation, that is, the control logic of a single frequency locking. After starting, the ultrasonic device 100 will work at a preset initial driving frequency. In a specific application, when the ultrasonic device 100 starts working, it can be judged whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100; it can also be judged whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100 after the ultrasonic device 100 is started and the driving frequency is adjusted.

[0066] As an embodiment, the control device 200 is also configured to perform the following operations within the mixing cycle of the target liquid 20: before the preset condition is met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, then it is determined whether the cumulative parameter of the frequency locking operation within a single mixing cycle is greater than or equal to the first preset value or whether the remaining parameter for the frequency locking operation within a single mixing cycle is less than the second preset value or whether the remaining time within a single mixing cycle is less than or equal to the third preset value, if yes, then it is determined that the frequency locking has failed; if not, then the ultrasonic device 100 is restarted to perform the frequency locking operation again. In the related art before this application, during the frequency locking process of a single mixing cycle, if it is determined that the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, then it is directly determined that the frequency locking has failed. In the present embodiment, during the frequency locking process of a single mixing cycle, before the frequency locking operation satisfies the preset conditions, if it is determined that the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it will further determine whether the frequency locking has failed or the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the accumulated parameters of the frequency locking operation in the single mixing cycle or the parameters remaining for the frequency locking operation in the single mixing cycle or the remaining time in the single mixing cycle. In this way, the frequency locking operation is performed twice or more in the mixing cycle of certain measurement items, thereby improving the frequency locking success rate in a single mixing cycle. That is, the present embodiment can improve the frequency locking success rate by multiple frequency locking in combination with the single frequency locking control logic under the mixing cycle timing limit of the sample analyzer 10, thereby avoiding unnecessary waste of samples and reagents and helping to improve the measurement throughput of the sample analyzer 10.

[0067] As an implementation mode, when it is determined that the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset value or the remaining parameter for the frequency locking operation in a single mixing cycle is less than the second preset value, in addition to determining that the frequency locking operation has failed, the frequency locking operation will also be controlled to stop. The determination of the frequency locking failure and the control to stop the frequency locking operation can be performed simultaneously; the determination of the frequency locking failure can be performed first and then the control to stop the frequency locking operation can be performed; or the control to stop the frequency locking operation can be performed first and then the determination of the frequency locking failure can be performed.

[0068] It should be noted that, after determining that the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, if it is not further determined whether the frequency locking has failed or the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the accumulated parameters of the frequency locking operation in a single mixing cycle or the parameters remaining for the frequency locking operation in a single mixing cycle, and simply extending the frequency locking time and / or increasing the number of frequency locking operations, it is easy to cause the following problems: (1) After simply extending the frequency locking time and / or increasing the number of frequency locking operations, although the frequency locking is successful, the remaining time in a single mixing cycle cannot meet the time requirement for stable ultrasound (the time requirement for working at the target driving frequency); (2) After multiple frequency locking, the preset conditions are still not met. If the ultrasonic device 100 is restarted to lock the frequency in a cycle, the container falls into a cyclic frequency locking, resulting in a failure of the entire machine timing exceeding the limit. In this embodiment, when the driving frequency of the ultrasonic transducer 110 exceeds the first preset frequency range, it is determined whether the frequency locking has failed or the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the accumulated parameters of the frequency locking operation in a single mixing cycle or the remaining parameters that can be used for the frequency locking operation in a single mixing cycle, thereby avoiding the occurrence of the above two problems.

[0069] As an embodiment, the control device 200 is further configured to adjust the driving frequency of the ultrasonic device 100 in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency. That is, in the frequency locking operation, if the ultrasonic device 100 is driven to work at the current driving frequency and it is determined that the preset condition is not met, the driving frequency is adjusted in a driving frequency unit step manner, which is easy to control.

[0070] As an implementation mode, the preset condition is a condition for characterizing whether the driving frequency of the ultrasonic device 100 reaches the resonant frequency. Specifically, when the driving frequency input to the ultrasonic device 100 is the same as the resonant frequency of the dynamic branch of the ultrasonic device 100, the unloaded dynamic branch of the ultrasonic device 100 is purely resistive, and the impedance of the ultrasonic device 100 is minimal at this time, thereby facilitating ensuring that a better ultrasonic mixing effect is achieved in a shorter time.

[0071] As an embodiment, the preset condition includes that the driving frequency of the ultrasonic device 100 is within a first preset range of the resonant frequency; and / or, the preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device 100 is within a second preset range. The first preset range is that the driving frequency of the ultrasonic device 100 is equal to the resonant frequency of the ultrasonic device 100 or is within a preset range close to the resonant frequency. The second preset range is that the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero, which can also indicate that the driving frequency of the ultrasonic device 100 is within the first preset range of the resonant frequency.

[0072] As an implementation mode, judging whether the preset condition is met according to the working parameters of the ultrasonic device 100 includes: judging whether the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero according to the working voltage and the working current of the ultrasonic device 100. In a specific application, the waveforms of the working voltage and the working current of the ultrasonic device 100 can be collected to judge whether the phase difference between the working voltage and the working current of the ultrasonic device 100 is zero or within a preset range close to zero, which is easy to implement.

[0073] As an implementation mode, the first preset value or the second preset value is determined by the measurement item corresponding to the target liquid 20. Since different measurement items may have different requirements for the stable ultrasonic time of the target liquid 20, the first preset value or the second preset value is set in accordance with each measurement item in this implementation mode, so that the frequency locking control mode of this implementation mode can adapt to the stable ultrasonic time requirements of different measurement items.

[0074] As an implementation mode, the cumulative parameter is the cumulative number of times. Whether the cumulative parameter of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset value includes: whether the cumulative number of frequency locking operations in a single mixing cycle is greater than or equal to the preset number of times. Specifically, during the frequency locking process, when the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is determined whether the frequency locking in the mixing cycle has failed or whether the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the number of frequency locking times. In this implementation mode, the number of frequency locking times is used as a basis for further determining whether the frequency locking has failed and whether the frequency locking can be performed again. This method is simple to control and easy to implement.

[0075] As an embodiment, the control device 200 is further configured to: within the mixing cycle, and after determining that the frequency locking is successful, drive the ultrasonic device 100 to work for a second preset time according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid 20; the product of the preset number of times and the time required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset time. The second preset time is the duration of stable ultrasound. The duration of stable ultrasound is the preset time required for the measurement item to drive the ultrasonic device 100 to work at the target driving frequency. The second preset time may be different for different measurement items. Driving the ultrasonic device 100 to work for the second preset time according to the driving frequency when the frequency locking is successful can be directly using the driving frequency when the frequency locking is successful as the target driving frequency to drive the ultrasonic device 100 to work for the second preset time, or it can be determined according to the driving frequency when the frequency locking is successful. The target driving frequency drives the ultrasonic device 100 to work for the second preset time. The duration of the mixing cycle can be a preset duration from starting the ultrasonic device 100 to shutting down the ultrasonic device 100, or a preset duration from the ultrasonic device 100 moving from the initial position to returning to the initial position after the ultrasonic operation is completed. In this embodiment, by limiting the relationship between the preset number of times, the duration required for a single frequency locking operation, the duration of the mixing cycle, and the second preset duration, it is beneficial to take into account the stable ultrasonic demand of the target liquid 20 and the frequency locking success rate.

[0076] As an implementation method, the formula N=floor[(Tt) / τ] for calculating the preset number of times can be pre-stored in the sample analyzer in advance. In this way, the sample analyzer can automatically calculate the preset number of times based on the formula and the input parameters of the ultrasonic drive timing requirement T (i.e., the time from starting the ultrasonic device 100 to shutting down the ultrasonic device 100), the stable ultrasonic time requirement t (the corresponding requirement is called according to different measurement items) t, and the single frequency locking time requirement τ (determined by the capability of the phase-locked loop locking judgment circuit). Among them, floor[] is a rounding function, t≤T, τ≤T. Of course, in specific applications, as an alternative implementation method, the preset number of times can also be pre-stored in the sample analyzer in advance without the need to be calculated according to the formula.

[0077] As an implementation method after the frequency locking fails, the control device 200 is further configured to: if the frequency locking fails, cancel the ultrasonic mixing operation on the target liquid 20, and re-measure the measurement items corresponding to the target liquid 20. In this implementation method, after the frequency locking fails, the target liquid 20 is directly discarded, and the mixing operation and measurement of the target liquid 20 are no longer performed.

[0078] As another implementation method after the frequency locking fails, the control device 200 is further configured to: if the frequency locking fails, continue to perform the ultrasonic mixing operation on the target liquid 20, continue to execute the measurement items corresponding to the target liquid 20, and add a mark to the measurement result corresponding to the target liquid 20. In this embodiment, after the frequency locking fails, the target liquid 20 is not discarded, the mixing operation and measurement of the target liquid 20 are continued, and a mark is added to the measurement result. The mark is used to prompt the operator that the frequency locking operation in the measurement result has failed.

[0079] As another implementation after frequency locking fails, the control device 200 is further configured to: if it is determined that frequency locking fails, record a log of frequency locking failure. In this implementation, by recording a log of frequency locking failure, it is convenient for operators to check the cause of frequency locking failure later.

[0080] As an embodiment, the control device 200 is also configured to: for at least two different measurement items and / or at least two different working modes of the sample analyzer 10, when it is determined that the frequency locking fails, different processing measures are respectively taken, and the different processing measures include at least two of the following processing measures: a first processing measure, a second processing measure, and a third processing measure. Among them, the first processing measure includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, or, the first processing measure includes: canceling the measurement of the target liquid 20, re-testing the sample measurement item corresponding to the target liquid 20, and recording a log of the frequency locking failure. The second processing measure includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, or, the second processing measure includes: continuing to perform the measurement of the target liquid 20, adding a mark to the measurement result corresponding to the target liquid 20, and recording a log of the frequency locking failure. The third processing measure includes: recording a log of the frequency locking failure. In specific applications, different treatment measures can be set for different measurement items according to their different requirements for ultrasonic mixing, so as to meet the needs of different measurement items and help avoid unnecessary waste of samples and reagents. For example: for measurement items that have relatively high requirements for whether the frequency locking is successful and / or have relatively high requirements for the ultrasonic mixing effect, the first treatment measure can be adopted; for measurement items that have relatively low requirements for whether the frequency locking is successful and / or have relatively low requirements for the ultrasonic mixing effect, the second treatment measure can be adopted; for measurement items that have basically no requirements for whether the frequency locking is successful and / or have basically no requirements for the ultrasonic mixing effect, the third treatment measure can be adopted. Of course, in specific applications, as an alternative implementation scheme, the sample analyzer 10 can also only set one or two of the first treatment measure, the second treatment measure, and the third treatment measure.

[0081] As an embodiment, the at least two different working modes of the sample analyzer 10 include a sample measurement mode and a debugging mode. The sample measurement mode is a mode for performing sample measurement, and the debugging mode is a mode for debugging the sample analyzer 10. The sample measurement mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different measurement items. The debugging mode can select one of the first processing measure and the third processing measure.

[0082] As an implementation manner, the working mode of the sample analyzer 10 further includes a quality control mode. The quality control mode can select one of the first processing measure, the second processing measure, and the third processing measure according to different quality control items.

[0083] As an embodiment, the ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is connected to the ultrasonic transducer 110, and the ultrasonic vibrator 120 is used to ultrasonically mix the target liquid 20 under the drive of the ultrasonic transducer 110. The control device 200 is electrically connected to the ultrasonic transducer 110 to control the operation of the ultrasonic transducer 110. The ultrasonic transducer 110 is an energy conversion device, which is mainly used to convert the electrical power input by the control device 200 into mechanical power (i.e., ultrasonic waves) and then transmit it out.

[0084] As an implementation mode, the ultrasonic transducer 110 includes a piezoelectric ceramic component 111. The piezoelectric ceramic component 111 is a component made of an electronic ceramic material having piezoelectric and sensitive properties, and can realize mutual conversion between mechanical energy and electrical energy.

[0085] As an embodiment, the ultrasonic vibrator 120 is an ultrasonic vibrator rod for at least partially inserting into the target liquid 20 for ultrasonic mixing. The ultrasonic vibrator 120 transmits ultrasonic waves to the target liquid 20 in a contact manner to achieve ultrasonic mixing of the target liquid 20, which helps to reduce the interference of other external components on the ultrasonic transmission. Of course, in specific applications, the arrangement of the ultrasonic vibrator 120 is not limited to this. For example, as an alternative embodiment, the ultrasonic vibrator 120 is a component for ultrasonically mixing the target liquid 20 in a non-contact manner, and its specific form includes but is not limited to the following situations: an ultrasonic mixing seat for placing a reaction container 30 loaded with the target liquid 20, a vibration rod for transmitting ultrasonic waves to the target liquid 20 from the side of the outside of the reaction container 30 loaded with the target liquid 20, and a vibration rod for inserting into the reaction container 30 loaded with the target liquid 20 but not inserting into the target liquid 20.

[0086] As an implementation mode, the ultrasonic vibration rod is a horn. The end surface of the ultrasonic vibration rod at one end away from the ultrasonic transducer 110 is the main output surface of the ultrasonic vibration rod for transmitting ultrasonic waves outward.

[0087] As an implementation manner, the ultrasonic device 100 further includes a driving mechanism, the ultrasonic transducer 110 and / or the ultrasonic vibrator 120 are connected to the driving mechanism, and the driving mechanism is used to drive the ultrasonic transducer 110 and the ultrasonic vibrator 120 to move.

[0088] As an implementation manner, the driving mechanism is at least used to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position, so that the ultrasonic vibrator 120 ultrasonically mixes the target liquid 20 at the ultrasonic mixing position.

[0089] As an implementation manner, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to drive the ultrasonic vibrator 120 to perform the ultrasonic mixing operation, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position.

[0090] As an implementation, the control device 200 is further configured to: before controlling the ultrasonic transducer 110 to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator 120 to move to the ultrasonic mixing position. Of course, in a specific application, as an alternative implementation, the frequency locking operation does not necessarily have to be performed at the ultrasonic mixing position.

[0091] As an implementation mode, the driving mechanism is used to drive the ultrasonic vibrator 120 to move in two-dimensional or three-dimensional space, so that the ultrasonic vibrator 120 moves to different working positions, such as a standby position, an ultrasonic mixing position, a cleaning position, etc.

[0092] As an embodiment, the sample analyzer 10 further includes a sample dispensing device 300, which is used to draw a sample from a sample container and distribute at least part of the drawn sample to a reaction container 30. The sample container is used to load a sample collected from a patient. The reaction container 30 is used to carry the sample for reaction and / or measurement. The sample dispensing device 300 is mainly used to achieve quantitative distribution of the sample.

[0093] As an implementation manner, the sample distributing device 300 is used to draw samples from a sample container located at a sample aspirating position and distribute them to a reaction container 30 located at a sample adding position.

[0094] As an embodiment, the sample dispensing device 300 includes a sample needle, a first motion driving device and a first suction and discharge driving device, wherein the first motion driving device is used to drive the sample needle to move in two-dimensional or three-dimensional space so as to move the sample needle to different positions, such as a standby position, a sample suction position, a sample addition position, a cleaning position, etc. The first suction and discharge driving device is used to drive the sample needle to perform suction and discharge actions.

[0095] As an embodiment, the sample analyzer 10 further includes a reagent dispensing device 400, which is used to absorb reagents from a reagent container and distribute at least part of the absorbed reagents to the reaction container 30. The reagent container is used to store reagents required for the assay. The reagent dispensing device 400 is mainly used to achieve quantitative distribution of reagents.

[0096] As an embodiment, the reagent dispensing device 400 includes a reagent needle, a second motion drive device and a second suction and discharge drive device, and the second motion drive device is used to drive the reagent needle to move in two-dimensional or three-dimensional space, so that the reagent needle moves to different workstations, such as a standby position, a reagent suction position, a reagent addition position, a cleaning position, etc. The second suction and discharge drive device is used to drive the reagent needle to perform suction and discharge actions. It should be noted that the reagent dispensing device 400 may include multiple reagent needles, multiple groups of second motion drive devices and multiple groups of second suction and discharge drive devices, and any two reagent needles can be used to absorb and dispense different types of reagents, respectively, or can be used to absorb and dispense the same type of reagent at different times.

[0097] As an embodiment, the sample analyzer 10 further includes a reagent loading device 600 for storing reagent containers. The reagent dispensing device 400 is used to absorb reagents from the reagent containers on the reagent loading device 600 and distribute at least part of the absorbed reagents into the reaction container 30.

[0098] As an implementation manner, the reagent loading device 600 is in the shape of a disk, and a plurality of reagent positions are formed thereon, and a plurality of reagent containers can be stored simultaneously.

[0099] As an embodiment, the sample analyzer 10 further includes a measuring device 500, which is used to measure the reaction solution made of at least the mixed solution. The measuring device 500 is used to measure the reaction solution in the reaction container 30. The measuring device 500 may be an optical measuring device 500.

[0100] As an embodiment, the sample analyzer 10 further includes an incubation device 700 and a transfer device 800. The incubation device 700 is used to incubate the liquid in the reaction container 30. The transfer device 800 is used to transfer the reaction container 30, for example, to transfer the reaction container 30 after sample addition to the incubation device 700. The reagent dispensing device 400 is used to dispense the reagent into the reaction container 30 located on the incubation device 700. The measuring device 500 is arranged beside the incubation device 700, so as to perform optical measurement on the reaction liquid in the reaction container 30 on the incubation device 700.

[0101] As an embodiment, the incubation device 700 is disc-shaped and has a plurality of incubation holes formed thereon, so that a plurality of reaction containers 30 can be incubated simultaneously.

[0102] As an embodiment, the incubation device 700 is a disc-shaped structure that can drive the reaction container 30 to rotate.

[0103] As an embodiment, the ultrasonic mixing station is located on the incubation device 700. The ultrasonic device 100 is used to ultrasonically mix the target liquid 20 in the reaction container 30 on the incubation device 700. Of course, in a specific application, as an alternative embodiment, the ultrasonic mixing station may not be located on the incubation device 700.

[0104] As an embodiment, the transfer device 800 includes at least one clamping component and at least one third motion driving device for driving the clamping component to move.

[0105] As an embodiment, the sample analyzer 10 also includes a reaction container providing device 900 and a reaction container 30 recovery device, the reaction container providing device 900 is used to provide the reaction container 30, and the reaction container 30 recovery device is used to recover the reaction container 30. The sample analyzer 10 also forms a recovery position, and the reaction container 30 recovery device is located below the recovery position. The transfer device 800 is also used to transfer the reaction container 30 from the incubation device 700 to the recovery position for release and recovery. In this embodiment, the reaction container 30 is a disposable container, that is, a reaction container 30 is recycled after completing a measurement project. Of course, in specific applications, the reaction container 30 can also be a recycled container, that is, the reaction container 30 completes a measurement project, can be cleaned in the sample analyzer 10 and then reused for other measurement projects.

[0106] As an embodiment, the sample analyzer 10 also includes a sample management device 101 and a sample transport device 102. The sample management device 101 is used to place a sample container loaded with a sample to achieve sample loading and storage. The sample transport device 102 is used to transport the sample container output by the sample management device 101 to the sample suction position.

[0107] As an embodiment, the control device 200 includes an ultrasonic control board 210 and a main control board 220. The ultrasonic control board 210 is used to control the operation of the ultrasonic device 100, and the main control board 220 is used to control at least the operation of the ultrasonic control board 210, the sample dispensing device 300, the reagent dispensing device 400, and the measuring device 500. In this embodiment, the ultrasonic control board 210 and the main control board 220 are two independent circuit boards. Of course, in a specific application, as an alternative embodiment, the ultrasonic control board 210 and the main control board 220 can also be integrated into one circuit board.

[0108] As an embodiment, the main control board 220 is also used to control the operation of the incubation device 700 , the transfer device 800 , the magnetic separation device 103 , the reaction container providing device 900 , the sample management device 101 and the sample transport device 102 .

[0109] As an embodiment, the sample is a blood sample, the sample analyzer 10 is an immunoanalyzer, and the sample analyzer 10 also includes a magnetic separation device 103, which is used to magnetically separate the liquid in the reaction container 30. The liquid treated by the magnetic separation device 103 includes a clear liquid and a magnetic bead liquid, the clear liquid is treated as a waste liquid, and the magnetic bead liquid is used to prepare a subsequent reaction liquid. The measurement process of a measurement item in the immunoanalyzer includes: adding a sample, adding a reagent to form a first mixed liquid, mixing and incubating the first mixed liquid to obtain a second mixed liquid, magnetically separating the second mixed liquid to obtain a liquid after magnetic separation, adding a substrate to the liquid after magnetic separation to obtain a third mixed liquid, mixing and incubating the third mixed liquid to obtain a reaction liquid, and optically measuring the reaction liquid. During the magnetic separation process, the operation of adding a separation liquid and mixing will be performed. The above-mentioned mixed liquid as the target liquid 20 includes at least one of the following situations: a first mixed liquid after adding a sample and a reagent and before incubation, a second mixed liquid during the magnetic separation process, and a third mixed liquid formed after the magnetic separation and the addition of a substrate and before incubation. Of course, in a specific application, the type of the sample analyzer 10 is not limited thereto. For example, as an alternative embodiment, the sample analyzer 10 may also be a biochemical analyzer, a blood routine cell analyzer, or a coagulation analyzer.

[0110] The present embodiment also provides a control method for the ultrasonic device 100 in the sample analyzer 10, and the control method includes the following steps: controlling the ultrasonic device 100 to start, judging whether the preset conditions are met according to the working parameters of the ultrasonic device 100 fed back, if yes, judging that the frequency locking is successful and stopping the frequency locking operation; if no, adjusting the driving frequency of the ultrasonic device 100, and executing the step of judging whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100, until the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range; before the preset conditions are not met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, judging whether the accumulated parameters of the frequency locking operation in a single mixing cycle are greater than or equal to the first preset value or whether the remaining parameters that can be used for the frequency locking operation in a single mixing cycle are less than the second preset value, if yes, judging that the frequency locking fails; if no, restarting the ultrasonic device 100 to perform the frequency locking operation again. In the present embodiment, the control method of the ultrasonic device 100 in the sample analyzer 10 is similar to the control principle described in the above-mentioned sample analyzer 10, and will not be described in detail here.

[0111] As an embodiment, the above control method also includes: within the mixing cycle, and after determining that the frequency locking is successful, driving the ultrasonic device 100 to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to drive the ultrasonic vibrator 120 to ultrasonically mix the target liquid 20.

[0112] As an implementation mode, in the above control method, whether the cumulative parameters of the frequency locking operation within a single mixing cycle are greater than or equal to a first preset value includes: within a single mixing cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

[0113] The specific principles and other implementations of the control method provided in this embodiment are similar to the control principles and implementations described in the above-mentioned sample analyzer 10 and will not be described in detail here.

[0114] This embodiment also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor (e.g., the processor in the control device 200 described above), the processor implements the steps of the control method of the ultrasonic device 100 in the sample analyzer 10 described above. The computer-readable storage medium may be an internal storage unit of the sample analyzer 10 described above, such as a hard disk or memory of the sample analyzer 10; or, the computer-readable storage medium may also be an external storage device of the sample analyzer 10, such as a plug-in hard disk, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (FlashCard), etc., equipped on the sample analyzer 10.

[0115] Compared with the solutions of single frequency locking judgment or simply extending the frequency locking time or simply increasing the number of frequency locking times in the related art, the control scheme of the ultrasound device 100 provided in this embodiment fully considers the requirements for high frequency locking success rate, fully considers the requirements for stable ultrasound duration, and fully utilizes the timing margin of the scene, and comprehensively considers the timing constraints, stable ultrasound time requirements, phase-locked loop frequency locking capabilities, etc. Under the timing constraints of the sample analyzer 10, it adapts to the stable ultrasound duration requirements of specific measurement items, calculates the number of frequency locking times, and combines the single frequency locking judgment logic to avoid unnecessary waste of samples and reagents through a limited number of frequency locking times, thereby improving the measurement throughput of the sample analyzer 10 and the effective mixing rate of a single sample.

[0116] As an implementation mode, in this embodiment, the frequency locking control principle of the ultrasonic device 100 includes:

[0117] A. The ultrasonic device 100 is mechanically in place.

[0118] B. Start the ultrasonic device 100, and drive the circuit to the set lower limit frequency f l The ultrasonic device 100 is driven to operate, that is, the driving frequency f at this time is f1.

[0119] C. Signal acquisition: collecting the working current and working voltage signals of the ultrasonic device 100.

[0120] D. Phase comparison: The phase comparison module detects the phase of the working current and working voltage signals of the ultrasonic device 100 to identify the phase difference between the working current and working voltage of the ultrasonic device 100. Is it zero or within a preset range close to zero? If so, go to step I; if not, go to step E.

[0121] E. Driving frequency unit step: the driving frequency is adjusted with a unit frequency Δf, that is, the adjusted driving frequency f=f1+Δf.

[0122] F. Frequency over-limit judgment: judge whether the adjusted driving frequency f exceeds the upper limit frequency f of the first preset frequency range h If yes, go to step G, if not, go to step C.

[0123] G. Restart times counting: The initial value n0 of the restart times after the machine is in place is 0, and it is counted as n=n0+1.

[0124] H. Determine the number of restarts: Determine whether n is less than or equal to the preset number N. If so, proceed to step B. Otherwise, determine that the frequency locking fails and end the frequency locking process. The preset number N can be calculated according to the formula N = floor[(Tt) / τ], where T is the ultrasonic drive timing requirement, t is the stable ultrasonic duration requirement, τ is the single frequency locking time requirement, and floor[] is a rounding function, t≤T, τ≤T.

[0125] I. Determine if the frequency locking is successful: Or when it is within the preset range of 0, it is determined that the frequency locking is successful and the frequency locking process ends.

[0126] The following takes the adaptive two-time frequency locking as an example when a mixed liquid is mixed for a certain measurement project to further illustrate the frequency locking control principle of the ultrasonic device 100:

[0127] A. The ultrasound device 100 is mechanically in place.

[0128] B. The ultrasonic device 100 is started, and the driving circuit drives the ultrasonic device 100 to operate at the set lower limit frequency of 34.8 kHz, that is, the driving frequency f at this time is 34.8 kHz.

[0129] C. Signal acquisition: collecting the working current and working voltage signals of the ultrasonic device 100.

[0130] D. The phase comparison module detects the phase of the working current and working voltage signals of the ultrasonic device 100, and identifies the phase difference of the working current and working voltage of the ultrasonic device 100. If it is not zero and is not within a preset range close to zero, go to step E.

[0131] E. Driving frequency unit step: The driving frequency is adjusted with a unit frequency of 0.1kHz, that is, the driving frequency f=34.8kHz+0.1kHz.

[0132] F. Frequency over-limit judgment: judge whether the adjusted driving frequency f does not exceed the upper limit frequency f of the first preset frequency range h =36.8kHz, repeat steps C, D, E, F until the adjusted drive frequency f exceeds f h .

[0133] G. Restart times count: count as n=n0+1=1.

[0134] H. Restart times judgment: n=1≤N=4, enter steps B, C, D, E, F, and repeat steps C, D, E, F. When f=35kHz, the phase discrimination result is

[0135] I. Determine if the frequency locking is successful: , determine that the frequency locking is successful, and end the frequency locking process.

[0136] Embodiment 2:

[0137] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the cumulative parameter and the first preset value are set differently, which is specifically reflected in that: in the first embodiment, the cumulative parameter is the cumulative number of frequency locking operations, and the first preset value is the preset number; while in this embodiment, the cumulative parameter is the cumulative duration of the frequency locking operation, and the first preset value is the first preset duration.

[0138] As an implementation mode, in this embodiment, whether the cumulative parameter of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset value includes: whether the cumulative duration of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset duration. Specifically, during the frequency locking process, when the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is determined whether the frequency locking in the mixing cycle has failed or whether the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the cumulative duration of the frequency locking operation. In this implementation mode, the cumulative duration of the frequency locking operation is used as a basis for further determining whether the frequency locking has failed and whether the frequency locking can be performed again, and this method is also easy to implement.

[0139] As an embodiment, the control device 200 is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device 100 to work for a second preset time according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid 20; the first preset time is less than or equal to the difference between the mixing cycle and the second preset time. In this embodiment, by limiting the relationship between the first preset time, the mixing cycle, and the second preset time, it is beneficial to take into account the stable ultrasonic demand of the target liquid 20 and the frequency locking success rate.

[0140] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0141] Embodiment three:

[0142] Reference Figure 1 , Figure 5 and Figure 6 As shown, the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in the basis for judging whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again. Specifically, in the first embodiment, it is judged whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again based on whether the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to the first preset value; while in the present embodiment, it is judged whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again based on whether the remaining time in a single mixing cycle is less than or equal to the third preset value.

[0143] As an implementation mode, in this embodiment, the control device 200 is configured to perform the following operations within the mixing cycle of the target liquid 20: before the preset conditions are met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is determined whether the remaining time in a single mixing cycle is less than or equal to a third preset value, and if so, it is determined that the frequency locking has failed; if not, the ultrasonic device 100 is restarted to perform the frequency locking operation again.

[0144] As an embodiment, whether the remaining time in a single mixing cycle is less than the third preset value includes: in a single mixing cycle, the remaining time is less than a second preset time, and the second preset time is a preset time for driving the ultrasonic device 100 to work according to the driving frequency when the frequency is successfully locked in the mixing cycle and after determining that the frequency is successfully locked to perform ultrasonic mixing on the target liquid 20. The second preset time is the time requirement for stable ultrasound.

[0145] As an implementation mode, in this embodiment, the frequency locking control principle of the ultrasonic device 100 includes:

[0146] A. The ultrasound device 100 is mechanically in place.

[0147] B. Start the ultrasonic device 100, and drive the circuit to the set lower limit frequency f l The ultrasonic device 100 is driven to operate, that is, the driving frequency f at this time is f1.

[0148] C. Signal acquisition: collecting the working current and working voltage signals of the ultrasonic device 100.

[0149] D. Phase comparison: The phase comparison module detects the phase of the working current and working voltage signals of the ultrasonic device 100 to identify the phase difference between the working current and working voltage of the ultrasonic device 100. Is it zero or within a preset range close to zero? If so, go to step I; if not, go to step E.

[0150] E. Driving frequency unit step: the driving frequency is adjusted with a unit frequency Δf, that is, the adjusted driving frequency f=f1+Δf.

[0151] F. Frequency over-limit judgment: judge whether the adjusted driving frequency f exceeds the upper limit frequency f of the first preset frequency range h If yes, go to step G, if not, go to step C.

[0152] G. Calculation of remaining time: Remaining time Δt = Tt n , where t n It is the total time length counted by the timer since the ultrasonic device 100 is started.

[0153] H. Remaining time judgment: judge whether the remaining time Δt is less than or equal to the stable ultrasonic time requirement t. If so, proceed to step B. If not, determine that the frequency locking fails and end the frequency locking process.

[0154] I. Determine if the frequency locking is successful: Or when it is within the preset range of 0, it is determined that the frequency locking is successful and the frequency locking process ends.

[0155] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0156] Embodiment 4:

[0157] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in the basis for judging whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again. Specifically, in the first embodiment, the judgment of whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again is based on judging whether the accumulated parameters of the frequency locking operation in a single mixing cycle are greater than or equal to the first preset value; while in the present embodiment, the judgment of whether the frequency locking fails or restarting the ultrasonic device 100 to perform the frequency locking operation again is based on judging whether the parameters remaining for the frequency locking operation in a single mixing cycle are less than the second preset value.

[0158] As an implementation mode, in this embodiment, the control device 200 is configured to perform the following operations within the mixing cycle of the target liquid 20: before the preset condition is met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is determined whether the remaining parameters that can be locked in a single mixing cycle are less than the second preset value. If yes, it is determined that the locking frequency has failed; if not, the ultrasonic device 100 is restarted to perform the locking frequency operation again. In a specific application, the minimum value of the remaining parameters that can be locked in a single mixing cycle can be calculated in advance and stored in the sample analyzer 10 as the second preset value. When the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, the remaining parameters that can be locked in a single mixing cycle are calculated and compared with the second preset value to determine whether the locking frequency has failed or the ultrasonic device 100 is restarted to perform the locking frequency operation again.

[0159] As an implementation mode, the remaining parameter that can be used for frequency locking operation is the remaining number of times that frequency locking operation can be performed. Whether the above-mentioned parameter that can be used for frequency locking operation in a single mixing cycle is less than a second preset value includes: in a single mixing cycle, the remaining number of times that frequency locking operation can be performed is less than one. When the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, and the remaining number of times that frequency locking operation can be performed in a single mixing cycle is less than one, it is determined that the frequency locking has failed. When the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, and the remaining number of times that frequency locking operation can be performed in a single mixing cycle is greater than or equal to one, the ultrasonic device 100 is restarted to perform the frequency locking operation again.

[0160] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0161] Embodiment five:

[0162] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the fourth embodiment mainly in that the remaining parameters that can be used for frequency locking operation and the second preset value are set differently, which is specifically reflected in that: in the fourth embodiment, the remaining parameters that can be used for frequency locking operation are the remaining number of times that can be used for frequency locking operation, and the second preset value is one; while in this embodiment, the remaining parameters that can be used for frequency locking operation are the remaining duration of the frequency locking operation, and the second preset value is the duration required for a single frequency locking operation.

[0163] As an implementation mode, in this embodiment, whether the remaining parameters for frequency locking operation in a single mixing cycle are less than the second preset value includes: in a single mixing cycle, the remaining time for frequency locking operation is less than the time required for a single frequency locking operation. When the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, and the remaining time for frequency locking operation in a single mixing cycle is less than the time required for a single frequency locking operation, it is determined that the frequency locking has failed. When the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, and the remaining time for frequency locking operation in a single mixing cycle is greater than or equal to the time required for a single frequency locking operation, the ultrasonic device 100 is restarted to perform the frequency locking operation again.

[0164] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first and fourth embodiments, and will not be described in detail here.

[0165] Embodiment six:

[0166] The sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment are different from those in the first embodiment mainly in that the setting function of the ultrasonic device 100 is different, which is specifically reflected in that: in the first embodiment, the ultrasonic device 100 is used to ultrasonically mix the target liquid 20; while in this embodiment, the ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20 to clean the parts to be cleaned.

[0167] As an implementation mode, the sample analyzer 10 provided in this embodiment includes a sample dispensing device 300, a reagent dispensing device 400, a measuring device 500, a cleaning liquid supply device, an ultrasonic device 100 and a control device 200. The sample dispensing device 300 includes a sample needle, which is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container 30; the reagent dispensing device 400 includes a reagent needle, which is used to draw a reagent from a reagent container and distribute at least a portion of the drawn reagent to the reaction container 30; the cleaning liquid supply device is used to supply a cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container 30 and the stirring rod. The ultrasonic device 100 is used to transmit ultrasonic waves to the target liquid 20, and the target liquid 20 is a cleaning liquid. The measuring device 500 is used to measure the reaction liquid made of at least a mixed liquid. The control device 200 is configured to control the ultrasonic device 100 to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid 20: control the ultrasonic device 100 to start, and determine whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100. If yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device 100, and perform the step of determining whether the preset conditions are met according to the working parameters fed back by the ultrasonic device 100, until the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range; the control device 200 is also configured to The following operations are performed during the ultrasonic working cycle of the target liquid 20: before the preset conditions are met, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range, it is determined whether the accumulated parameters of the frequency locking operation within a single ultrasonic working cycle are greater than or equal to the first preset value, or whether the remaining parameters that can be used for the frequency locking operation within a single ultrasonic working cycle are less than the second preset value, or whether the remaining time within a single ultrasonic working cycle is less than or equal to the third preset value. If so, it is determined that the frequency locking has failed; if not, the ultrasonic device 100 is restarted to perform the frequency locking operation again. In this embodiment, when the ultrasonic device 100 is used for ultrasonic cleaning, in a single ultrasonic working cycle, if the driving frequency of the ultrasonic device 100 is adjusted to exceed the first preset frequency range before the frequency locking operation meets the preset conditions, then it is further determined whether the frequency locking has failed or the ultrasonic device 100 can be restarted to perform the frequency locking operation again based on the accumulated parameters of the frequency locking operation in the single ultrasonic working cycle or the remaining time of the parameters that can be used for the frequency locking operation in the single ultrasonic working cycle. Therefore, under the timing limit of the ultrasonic working cycle of the sample analyzer 10, combined with the single frequency locking control logic, when the single frequency locking does not meet the preset conditions, the frequency locking success rate in the ultrasonic working cycle can be improved by performing two or more frequency locking operations, which can help improve the success rate and cleaning effect of ultrasonic cleaning, and help avoid the impact on the results and flux of the measurement items due to the failure of frequency locking in ultrasonic cleaning.

[0168] As an embodiment, when the ultrasonic device 100 is used to clean the sample needle, the sample analyzer 10 further includes a first cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the first cleaning tank to clean the sample needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a first ultrasonic seat arranged outside the first cleaning tank, and the first ultrasonic seat is used to transmit ultrasonic waves from outside the first cleaning tank to the cleaning liquid in the first cleaning tank to clean the sample needle inserted into the first cleaning tank.

[0169] As an embodiment, when the ultrasonic device 100 is used to clean the reagent needle, the sample analyzer 10 also includes a second cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the second cleaning tank to clean the reagent needle. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, and the ultrasonic vibrator 120 is a second ultrasonic seat arranged outside the second cleaning tank. The second ultrasonic seat is used to transmit ultrasonic waves from outside the second cleaning tank to the cleaning liquid in the second cleaning tank to clean the reagent needle inserted into the second cleaning tank.

[0170] As an embodiment, when the ultrasonic device 100 is used to clean the stirring rod, the stirring rod is used to stir the sample or reagent or the mixture of the sample and the reagent in the reaction container 30. The sample analyzer 10 also includes a third cleaning tank, and the cleaning liquid supply device is used to supply cleaning liquid to the third cleaning tank to clean the stirring rod. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120. The ultrasonic vibrator 120 is a third ultrasonic seat provided outside the third cleaning tank. The third ultrasonic seat is used to transmit ultrasonic waves from outside the third cleaning tank to the cleaning liquid in the third cleaning tank to clean the stirring rod inserted into the third cleaning tank.

[0171] As an embodiment, when the ultrasonic device 100 is used to clean the reaction container 30, the cleaning liquid supply device is used to supply the cleaning liquid to the reaction container 30 to clean the reaction container 30. The ultrasonic device 100 includes an ultrasonic transducer 110 and an ultrasonic vibrator 120, the ultrasonic vibrator 120 is an ultrasonic vibration rod inserted into the reaction container 30 or a fourth ultrasonic seat provided outside the reaction container 30, and the ultrasonic vibrator 120 is used to transmit ultrasonic waves to the cleaning liquid in the reaction container 30 to clean the reaction container 30.

[0172] As an embodiment, the control device 200 is also configured to: within the ultrasonic working cycle, and after determining that the frequency locking is successful, drive the ultrasonic device 100 to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid 20.

[0173] As an implementation mode, whether the accumulated parameters of the frequency locking operation within a single ultrasonic working cycle are greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation within a single ultrasonic working cycle is greater than or equal to a first preset duration, wherein the first preset duration is less than or equal to the difference between the duration of the ultrasonic working cycle and a second preset duration.

[0174] As another embodiment, whether the cumulative parameters of the frequency locking operation within a single ultrasonic working cycle are greater than or equal to a first preset value includes: within a single ultrasonic working cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the ultrasonic working cycle and the second preset duration.

[0175] The ultrasonic cleaning of this embodiment can adapt to the stable ultrasonic duration requirements of specific measurement items or specific parts to be cleaned under the timing constraints of the sample analyzer 10, calculate the number of lockable frequencies and the lockable frequency duration, and combine the single lock frequency judgment logic to maximize the efficiency and cleanliness of a single ultrasonic cleaning through a limited number of lock frequency times.

[0176] Except for the above differences, other parts of the sample analyzer 10 and the control method of the ultrasonic device 100 in the sample analyzer 10 provided in this embodiment can refer to the first to fifth embodiments and will not be described in detail here.

[0177] The above description is only a preferred embodiment of the present invention, and does not limit the patent scope of the present invention. All equivalent structural changes made by using the contents of the present invention specification and drawings under the inventive concept of the present invention, or directly / indirectly applied in other related technical fields are included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device is used to draw a sample from a sample container and distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device is used to suck the reagent from the reagent container and distribute at least part of the sucked reagent to the reaction container; An ultrasonic device, the ultrasonic device comprising a device for ultrasonically mixing a target liquid, the target liquid comprising one of the sample, the reagent, and a mixed liquid containing at least the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation during the mixing period of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device; if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and perform the step of determining whether the preset condition is met according to the working parameters fed back by the ultrasonic device, until the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range; The control device is also configured to perform the following operations within the mixing cycle of the target liquid: before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, determine whether the cumulative parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value or whether the remaining time within the single mixing cycle is less than or equal to the third preset value; if so, determine that the frequency locking has failed; if not, restart the ultrasonic device to perform the frequency locking operation again.

2. The sample analyzer according to claim 1, wherein: Whether the accumulated parameter of the frequency locking operation in the single mixing cycle is greater than or equal to the first preset value includes: whether the accumulated duration of the frequency locking operation in the single mixing cycle is greater than or equal to the first preset duration.

3. The sample analyzer according to claim 2, wherein: The control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid; The first preset duration is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

4. The sample analyzer according to claim 1, wherein: Whether the accumulated parameter of the frequency locking operation in the single mixing cycle is greater than or equal to the first preset value includes: whether the accumulated number of the frequency locking operations in the single mixing cycle is greater than or equal to the preset number.

5. The sample analyzer according to claim 4, characterized in that: The control device is further configured to: within the mixing cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to ultrasonically mix the target liquid; The product of the preset number of times and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

6. The sample analyzer according to claim 1, wherein: Whether the remaining parameters for the frequency locking operation in a single mixing cycle are less than a second preset value includes: in a single mixing cycle, the remaining duration for the frequency locking operation is less than the duration required for a single frequency locking operation; or, Whether the remaining parameters for the frequency locking operation in a single mixing cycle are less than a second preset value includes: in a single mixing cycle, the remaining number of times the frequency locking operation can be performed is less than one; or, Whether the remaining time in a single mixing cycle is less than a third preset value includes: within a single mixing cycle, the remaining time is less than a second preset time, and the second preset time is a preset time during the mixing cycle and after it is determined that the frequency is locked successfully, and the ultrasonic device is driven to work according to the driving frequency when the frequency is locked successfully to perform ultrasonic mixing on the target liquid.

7. The sample analyzer according to any one of claims 1 to 6, characterized in that: The first preset value, the second preset value, or the third preset value is determined by a measurement item corresponding to the target liquid.

8. The sample analyzer according to claim 1, wherein: The preset condition includes that the driving frequency of the ultrasonic device is within a first preset range of the resonant frequency; and / or, The preset condition includes that the phase difference between the working current and the working voltage of the ultrasonic device is within a second preset range.

9. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The ultrasonic device comprises an ultrasonic transducer, an ultrasonic vibrator and a driving mechanism, wherein the ultrasonic vibrator is connected to the ultrasonic transducer to perform ultrasonic mixing on the target liquid under the drive of the ultrasonic transducer; The driving mechanism is connected to the ultrasonic transducer and / or the ultrasonic vibrator to at least drive the ultrasonic vibrator to move to the ultrasonic mixing position, so that the ultrasonic vibrator ultrasonically mixes the target liquid at the ultrasonic mixing position; The control device is further configured to: before controlling the ultrasonic transducer to perform the frequency locking operation, control the driving mechanism to drive the ultrasonic vibrator to move to the ultrasonic mixing position.

10. The sample analyzer according to claim 9, characterized in that: The ultrasonic vibrator is an ultrasonic vibrating rod used to be at least partially inserted into the target liquid for ultrasonic mixing.

11. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The ultrasonic vibrator is a component for ultrasonically mixing the target liquid in a non-contact manner.

12. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The control device is further configured to: if it is determined that the frequency locking fails, cancel the ultrasonic mixing operation on the target liquid, and re-measure the measurement items corresponding to the target liquid; or, The control device is further configured to: if it is determined that the frequency locking fails, continue to perform the ultrasonic mixing operation on the target liquid, continue to execute the measurement items corresponding to the target liquid, and add a mark to the measurement result corresponding to the target liquid.

13. The sample analyzer according to any one of claims 1 to 6 or 8, characterized in that: The control device is further configured to adjust the driving frequency of the ultrasonic device in the following manner: the driving frequency after each adjustment is equal to the sum of the driving frequency before the adjustment and the second preset frequency.

14. A sample analyzer, characterized in that: include: A sample dispensing device, the sample dispensing device comprising a sample needle, the sample needle being used to draw a sample from a sample container and to distribute at least a portion of the drawn sample to a reaction container; A reagent dispensing device, the reagent dispensing device comprising a reagent needle, the reagent needle being used to draw a reagent from a reagent container and to dispense at least a portion of the drawn reagent into the reaction container; a cleaning liquid supply device, the cleaning liquid supply device being used to supply cleaning liquid to clean one of the sample needle, the reagent needle, the reaction container, and the stirring rod; An ultrasonic device, the ultrasonic device is used to transmit ultrasonic waves to a target liquid, the target liquid being one of the sample, the reagent, the cleaning liquid, and a mixed liquid at least containing the sample and the reagent; a measuring device for measuring a reaction solution made of at least a mixed solution; A control device, wherein the control device is configured to control the ultrasonic device to perform the following frequency locking operation within the ultrasonic working cycle of the target liquid: control the ultrasonic device to start, and determine whether a preset condition is met according to the working parameters fed back by the ultrasonic device, if yes, determine that the frequency locking is successful and stop the frequency locking operation; if not, adjust the driving frequency of the ultrasonic device, and perform the step of determining whether the preset condition is met according to the working parameters fed back by the ultrasonic device, until the driving frequency of the ultrasonic device is adjusted to exceed a first preset frequency range; The control device is also configured to perform the following operations within the ultrasonic working cycle of the target liquid: before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, determine whether the cumulative parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value or whether the remaining time within the single mixing cycle is less than or equal to the third preset value; if so, determine that the frequency locking has failed; if not, restart the ultrasonic device to perform the frequency locking operation again.

15. The sample analyzer according to claim 14, characterized in that: The control device is further configured to: within the ultrasonic working cycle and after determining that the frequency locking is successful, drive the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to transmit ultrasonic waves to the target liquid. Wherein, whether the accumulated parameter of the frequency locking operation in a single ultrasonic working cycle is greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation in a single ultrasonic working cycle is greater than or equal to a first preset duration, wherein the first preset duration is less than or equal to the difference between the duration of the ultrasonic working cycle and the second preset duration; or, Whether the cumulative parameters of the frequency locking operation within a single ultrasonic working cycle are greater than or equal to a first preset value includes: within a single ultrasonic working cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the ultrasonic working cycle and the second preset duration.

16. A method for controlling an ultrasonic device in a sample analyzer, characterized in that: The steps include: Controlling the ultrasonic device to start, judging whether a preset condition is met according to the working parameters fed back by the ultrasonic device, and if so, determining that the frequency locking is successful and stopping the frequency locking operation; if not, adjusting the driving frequency of the ultrasonic device, and executing the step of judging whether the preset condition is met according to the working parameters fed back by the ultrasonic device until the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range; Before the preset condition is met, if the driving frequency of the ultrasonic device is adjusted to exceed the first preset frequency range, it is determined whether the accumulated parameters of the frequency locking operation within the single mixing cycle are greater than or equal to the first preset value, or whether the remaining parameters for the frequency locking operation within the single mixing cycle are less than the second preset value, or whether the remaining time within the single mixing cycle is less than or equal to the third preset value. If so, it is determined that the frequency locking has failed; if not, the ultrasonic device is restarted to perform the frequency locking operation again.

17. The control method of the ultrasonic device in the sample analyzer according to claim 16, characterized in that: The control method further includes: within the mixing cycle and after determining that the frequency locking is successful, driving the ultrasonic device to work for a second preset time period according to the driving frequency when the frequency locking is successful, so as to drive the ultrasonic vibrator to ultrasonically mix the target liquid; Wherein, whether the accumulated parameter of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset value includes: whether the accumulated duration of the frequency locking operation in a single mixing cycle is greater than or equal to a first preset duration, wherein the first preset duration is less than or equal to the difference between the duration of the mixing cycle and the second preset duration; or, Whether the cumulative parameters of the frequency locking operation within a single mixing cycle are greater than or equal to a first preset value includes: within a single mixing cycle, whether the cumulative number of frequency locking operations is greater than or equal to a preset number, wherein the product of the preset number and the duration required for a single frequency locking operation is less than or equal to the difference between the duration of the mixing cycle and the second preset duration.

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