Bactericidal composition containing moroxydine hydrochloride and application thereof

By combining morpholinguanidine hydrochloride, cinarine and biological enzyme preparations, a bactericidal composition for preventing and treating plant virus diseases was prepared, which solved the poor bactericidal effect, limited bactericidal spectrum and preparation process in the prior art. Complex problems have achieved the effect of significantly improving the prevention and treatment effect and delaying the production of drug resistance.

CN119488105APending Publication Date: 2025-02-21SHAANXI ZHONGWEI BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411647679.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-18
Publication Date
2025-02-21

AI Technical Summary

Technical Problem

During the use of existing sterilization compositions, there are problems such that mass ratio affects the sterilization effect, limited sterilization spectrum, poor drug resistance delay effect, and complex preparation process.

Method used

Morpholinguanidine hydrochloride, cinarine and biological enzyme preparation are compounded with each other, the mass ratio of the active ingredients is adjusted, and agriculturally acceptable auxiliary ingredients are added to prepare a bactericidal composition in various dosage forms.

Benefits of technology

It significantly improves the prevention and treatment effect of plant virus diseases, delays the generation of drug resistance of pathogens, reduces the prevention and treatment cost, and improves the stability and safety of the bactericidal composition.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention belongs to the technical field of agriculture, and particularly relates to a bactericidal composition containing moroxydine hydrochloride, the bactericidal composition comprises an active component A, an active component B and a biological enzyme preparation, the active component A is moroxydine hydrochloride, and the active component B is Xinjunan or acetate thereof. The bactericidal composition provided by the invention has an obvious synergistic effect, can effectively reduce the dosage and the medication frequency of medicaments, reduces the cost, and also can delay the drug resistance of pathogenic bacteria.
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Description

Technical Field

[0001] The invention belongs to the technical field of pesticide chemistry, and particularly relates to a fungicide composition containing morpholinoguanidine hydrochloride and application thereof. Background Art

[0002] Plant viral diseases have become the second largest disease after fungal diseases, causing great losses to agricultural production every year. Bactericidal compositions are one of the commonly used means. Existing bactericidal compositions are usually composed of two bactericidal active ingredients, for example, morpholino hydrochloride and cinclofenac or its acetate are mixed in a certain proportion. This composition can be used to prevent and control diseases on various crops, such as black streaked dwarf disease, downy mildew, powdery mildew, blight, viral diseases, etc.

[0003] Morphoguanidine hydrochloride is a broad-spectrum, low-toxic virus control agent. After being applied to the leaves of plants, it can enter the plant body through the water pores, inhibit or destroy the formation of nucleic acids and lipoproteins, prevent the replication of viruses, and play a role in preventing and controlling viruses. Sinclozolin and its acetate are alkyl polyamine fungicides. They have excellent control effects on fungi, bacteria, and viruses in four subphyla, including semi-mycotic, basidia, flagella, and asci. The mechanism of action is that it can produce ionization in aqueous solution. Its hydrophilic group contains strong positive charge, which adsorbs various bacteria and viruses that are usually negatively charged, thereby destroying the cell membranes of various pathogens, coagulating proteins, and preventing respiration and enzyme activities. It kills viruses. It has certain systemic and osmotic effects, and has significant killing and inhibitory effects on viruses that cause crop diseases.

[0004] However, there are also some problems in the use of existing bactericidal compositions, such as the mass ratio of morpholino hydrochloride and cintamidine or its acetate has a great influence on the bactericidal effect. If the mass ratio is not appropriate, it may lead to poor bactericidal effect; existing bactericidal compositions usually contain only two bactericidal active ingredients, which may limit the expansion of the bactericidal spectrum and the delay of pathogenic bacteria resistance; existing bactericidal compositions may involve complex chemical reactions during the preparation process, which may affect the stability and safety of the bactericidal composition. Therefore, how to prepare a bactericidal composition that has both good bactericidal effect and a wide bactericidal spectrum, and a relatively simple and stable preparation process, is an important problem facing the current technology. After research by the inventor, it was found that compounding morpholino hydrochloride, cintamidine, and biological enzyme preparations has a good synergistic effect within a certain range. And there is no relevant report on the compounding of morpholino hydrochloride, cintamidine, and biological enzyme preparations at home and abroad. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a bactericidal synergistic composition which has good prevention effect, can delay the generation of drug resistance of pathogens, is safe for crops and is suitable for preventing and controlling plant viral diseases.

[0006] To achieve the above object, the technical solution adopted by the present invention is: a fungicide composition containing morpholino hydrochloride, the fungicide composition comprising active ingredient A, active ingredient B, and a biological enzyme preparation, the active ingredient A is morpholino hydrochloride, and the active ingredient B is cinclofenac or its acetate;

[0007] Furthermore, the mass ratio of the active ingredient A to the active ingredient B is 1:20 to 20:1;

[0008] Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:5 to 10:1;

[0009] Furthermore, the mass ratio of the active ingredient A to the active ingredient B is 1:5, 1:2, 1:1, 5:4, 25:18, 5:1, 50:9, 7:1, 10:1;

[0010] Furthermore, the biological enzyme preparation is a mixture of saccharifying enzyme, urease, cellulase, phytase and protease;

[0011] Furthermore, the mass ratio of saccharifying enzyme, urease, cellulase, phytase and protease is 2:1:1:1:2;

[0012] Furthermore, the mass ratio of saccharifying enzyme, urease, cellulase, phytase and protease is 3:1:1:1:1;

[0013] Furthermore, the mass ratio of saccharifying enzyme, urease, cellulase, phytase and protease is 2:1:1:2:1;

[0014] Furthermore, the fungicide composition includes agriculturally acceptable auxiliary ingredients in addition to the active ingredients. The fungicide composition includes agriculturally acceptable auxiliary ingredients in addition to the active ingredients. The auxiliary ingredients include one or more of solvents, emulsifiers, wetting agents, dispersants, stabilizers, antifreeze agents, thickeners, disintegrants, defoaming agents, preservatives and fillers. The above auxiliary ingredients are all commonly used or permitted ingredients in pesticide preparations and are not particularly limited. The specific ingredients and amounts can be adjusted and selected according to the formulation requirements.

[0015] The selection range of adjuvants in the above-mentioned various dosage forms is the same, as follows:

[0016] Further, the solvent is any one of xylene or biodiesel, toluene, diesel, methanol, ethanol, n-butanol, isopropanol, turpentine, solvent oil, dimethylformamide, dimethyl sulfoxide, water and the like, or a mixed solvent of more than one of them in any proportion;

[0017] Further, the emulsifier is selected from calcium dodecylbenzene sulfonate and any one of fatty acid polyoxyethylene ether, alkylphenol polyoxyethylene ether sulfosuccinate, styrylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, fatty acid polyoxyethylene ester, polyoxyethylene fatty alcohol ether, or a mixture of any one or more of them in any proportion;

[0018] Furthermore, the wetting agent is selected from: one or more of sodium dodecyl sulfate, calcium dodecylbenzene sulfonate, pull-opening powder BX., wetting penetrant F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phenyl phosphate, saponin powder, silkworm feces, and soapberry powder;

[0019] Furthermore, the dispersant is selected from one or more of polycarboxylates, lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, alkylbenzene sulfonate calcium salts, naphthalenesulfonic acid formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers;

[0020] Furthermore, the stabilizer is selected from: sodium citrate, resorcinol;

[0021] Furthermore, the antifreeze agent is selected from: one or more of ethylene glycol, propylene glycol, and glycerol;

[0022] Furthermore, the thickener is selected from: one or more of xanthan gum, hydroxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, and polyvinyl alcohol;

[0023] The defoaming agent is selected from one or more of silicone oil, silicone compounds, C10-20 saturated fatty acid compounds, and C8-10 fatty alcohol compounds;

[0024] The disintegrant is selected from one or more of bentonite, urea, ammonium sulfate, aluminum chloride, citric acid, succinic acid, sodium bicarbonate

[0025] Furthermore, the filler is selected from one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch, and light calcium carbonate.

[0026] Furthermore, the preservative is selected from: kason, sodium benzoate, benzoic acid and the like.

[0027] Furthermore, the fungicidal composition can be prepared into a formulation that is permitted in agriculture;

[0028] Furthermore, the dosage form of the preparation is a soluble solution, emulsifiable concentrate, latex, dispersible liquid, ointment, aqueous solution, aqueous emulsion, microemulsion, suspension, dispersible oil suspension, wettable powder, or water dispersible granule;

[0029] Furthermore, the dosage form of the preparation is an aqueous solution, an aqueous emulsion, a suspension, or a water-dispersible granule;

[0030] A fungicidal composition containing morpholinoguanidine hydrochloride for preventing and treating plant viral diseases;

[0031] Furthermore, the plant viral disease is tobacco mosaic virus TMV, cucumber mosaic virus CMV;

[0032] Furthermore, the plants are eggplant, tomato, cucumber and tobacco.

[0033] Furthermore, the fungicidal composition is applied to the crops to be controlled or the area where the crops grow in an effective dose.

[0034] Since the bactericidal composition of the present invention has a wide bactericidal spectrum, it can be used to prevent and treat more pathogens, which will greatly promote the development and application of drugs. In the field of microbial control, the bactericidal composition of the present invention can effectively delay the development of drug resistance in pathogens, which is of great significance for controlling the spread and prevalence of diseases. In addition, since the bactericidal composition of the present invention has good stability and safety, it can be widely used in various environments, including agriculture, medical treatment, food processing, etc. In general, the bactericidal composition of the present invention has broad application prospects in the fields of pesticide chemistry, drug synthesis, and microbial control, and the market demand is huge, and it is expected to promote technological progress and industrial development in related fields.

[0035] Compared with the prior art, the plant growth regulator aqueous solution of the present invention has the following advantages:

[0036] 1) The fungicidal composition of the present invention has an obvious synergistic effect on the prevention and treatment of plant viral diseases, significantly improving the prevention and treatment effect;

[0037] 2) Compared with a single agent, the fungicide composition of the present invention can effectively reduce the amount of the agent used and the number of times the agent is used, thereby reducing the cost of prevention and treatment;

[0038] 3) The bactericidal composition of the present invention contains a biological enzyme preparation, which can enhance the bactericidal effect of the bactericidal active ingredients and delay the drug resistance of pathogens. DETAILED DESCRIPTION

[0039] In order to make the present application easier to understand, the present application will be further described in detail below in conjunction with the examples, which are merely illustrative and are not intended to limit the scope of application of the present application. The raw materials or components used in the present application can be obtained through commercial routes or conventional methods unless otherwise specified.

[0040] Preparation Example

[0041] In order to better illustrate the present invention, the content of the present invention is further described below in conjunction with the embodiments. The parts in all the embodiments are parts by weight.

[0042] Preparation Example 1: 12% morpholinoguanidine hydrochloride·sphenanthracene suspension (3:1)

[0043] Formula: by weight percentage, 9% morpholino hydrochloride, 3% cintamidine, 3.5% biological enzyme preparation (1% saccharifying enzyme, 0.5% urease, 0.5% cellulase, 1% phytase, 0.5% protease), 1% naphthalenesulfonate formaldehyde condensate, 3% alkylphenol polyoxyethylene ether phosphate, 0.2% xanthan gum, 1% magnesium aluminum silicate, 4% propylene glycol, 0.2% sodium benzoate, 0.5% silicone oil, and deionized water to make up the balance;

[0044] Preparation method: According to the formula ratio, the active ingredients, surfactants and other functional additives are placed in a reactor in sequence, water is added to mix evenly, high-speed shearing and wet sand grinding are performed, biological enzyme preparations are added, and finally the suspension product is obtained by homogenization filtration.

[0045] Preparation Example 2: 5.9% morpholinoguanidine hydrochloride·sphenanthracene aqueous solution (5:0.9)

[0046] Formula: by weight percentage, 5% morpholino hydrochloride, 0.9% cintamidine, 3.5% biological enzyme preparation (1% saccharifying enzyme, 0.5% urease, 0.5% cellulase, 0.5% phytase, 1% protease), 10% sodium lignin sulfonate, 10% polyoxyethylene dodecyl alcohol ether, 5% ethanol, and deionized water to make up the balance.

[0047] Preparation method: According to the formula ratio, morpholino hydrochloride, cintamidine, biological enzyme preparation, surfactant, solubilizer and water are stirred and mixed evenly to prepare an aqueous product with a homogeneous and stable appearance.

[0048] Preparation Example 3: 4.3% morpholino hydrochloride·sphenanthracene aqueous solution (2.8:1.5)

[0049] Formula: by weight percentage, 2.8% morpholino hydrochloride, 1.5% cintamidine, 3.5% biological enzyme preparation (1.5% saccharifying enzyme, 0.5% urease, 0.5% cellulase, 0.5% phytase, 0.5% protease), 7.5% sodium lignin sulfonate, 12.5% ​​dodecynyl alcohol polyoxyethylene ether, 5% ethanol, and deionized water to make up the balance;

[0050] Preparation method: Same as Preparation Example 1.

[0051] Preparation Example 4: 15% morpholinoguanidine hydrochloride·sphenanthracene water dispersible granules (2:1)

[0052] Formula: calculated by weight percentage: 10% morpholino hydrochloride, 5% cintamidine, 3.5% biological enzyme preparation (1% saccharifying enzyme, 0.5% urease, 0.5% cellulase, 0.5% phytase, 1% protease), 7.5% lignin sulfonate, 4.5% sodium dodecylbenzene sulfonate, 3% sodium dodecyl sulfate, 5% white carbon black, and kaolin makes up the balance.

[0053] Preparation method: according to the formula ratio of the embodiment, the active ingredients of morpholinamide hydrochloride and cintamidine are added to the carrier, and a surfactant, a biological enzyme preparation and other functional additives are added thereto, mixed, and after air flow pulverization, 10-25% of water is added, and then kneading, granulation, drying and sieving are performed to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water in a boiling granulator, granulated, dried, and then sieved to obtain a water-dispersible granule product.

[0054] Preparation Example 5: 4.8% morpholinoguanidine hydrochloride·sphenanthracene aqueous emulsion (3.8:1)

[0055] Formula: by weight percentage, 3.8% morpholino hydrochloride, 1% cintamidine, 3.5% biological enzyme preparation (1% saccharifying enzyme, 0.5% urease, 1% cellulase, 0.5% phytase, 0.5% protease), 8% EO-PO block copolymer, 18% cyclohexanone, 0.1% xanthan gum, 5% propylene glycol, 0.5% sodium benzoate, 0.1% silicone defoamer, and deionized water to make up the balance.

[0056] Preparation method: According to the formula design, the surfactant, antifreeze agent, density regulator and water are mixed into an aqueous phase, and then the morpholino hydrochloride and cintamidine are dissolved in a solvent and added to the aqueous phase under stirring. After stirring evenly, the biological enzyme preparation, thickener and preservative are added and shearing is continued for 10 minutes, and then the defoamer is added and stirred evenly to form an O / W type aqueous emulsion.

[0057] Comparative Example 1: 5.9% morpholino hydrochloride·sphenanthracene aqueous solution (5:0.9)

[0058] Formula: by weight percentage, 5% morpholinoguanidine hydrochloride, 0.9% cintamidine, 10% sodium lignin sulfonate, 10% polyoxyethylene dodecyl alcohol ether, 5% ethanol, and deionized water to make up the balance.

[0059] Preparation method: According to the formula ratio, morpholino hydrochloride, cintamidine, surfactant, solubilizer and water are stirred and mixed evenly to prepare an aqueous product with a homogeneous and stable appearance.

[0060] Comparative Example 2: 4.3% morpholino hydrochloride·sphenanthracene aqueous solution (2.8:1.5)

[0061] Formula: by weight percentage, 2.8% morpholinoguanidine hydrochloride, 1.5% cintamidine, 7.5% sodium lignin sulfonate, 12.5% ​​dodecynyl alcohol polyoxyethylene ether, 5% ethanol, and deionized water to make up the balance;

[0062] Preparation method: Same as control example 1.

[0063] Comparative Example 3: 15% morpholino hydrochloride·sphenanthracene water dispersible granules (2:1)

[0064] Formula: calculated by weight percentage, 10% morpholino hydrochloride, 5% cintamidine, 7.5% lignin sulfonate, 4.5% sodium dodecylbenzene sulfonate, 3% sodium dodecyl sulfate, 5% white carbon black, and kaolin makes up the balance.

[0065] Preparation method: according to the formula ratio of the embodiment, the active ingredients of morpholinamide hydrochloride and cintamidine are added to the carrier, and a surfactant and other functional additives are added thereto, mixed, and after air flow pulverization, 10-25% of water is added, and then kneading, granulation, drying, and sieving are performed to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water in a boiling granulator, granulated, dried, and then sieved to obtain the product.

[0066] Indoor bioassay

[0067] Test virus: Tomato virus disease (CMV)

[0068] Test method: Tomato seedlings were artificially inoculated with CMV, and the test agent was applied to half of the inoculated leaves before inoculation. Three leaves were treated for each plant, 30 plants were treated with each agent, and the test was repeated 3 times.

[0069] Investigation method: Half a month later, investigate the number of dead spots on the half leaf coated with pesticide and the half leaf not coated with pesticide.

[0070] Test results: The test results show (Table 1) that the mixture of guanidine hydrochloride and cintamidine in Preparation Examples 1 to 4 applied to the inoculated leaves before inoculation has a good preventive effect on CMV, and the preventive effect is more than 70%; the mixture of guanidine hydrochloride and cintamidine in Preparation Example 5 is second, with an inhibition rate of 76.88%. The combination of guanidine hydrochloride, cintamidine or its acetate and biological agents can achieve an antiviral effect.

[0071] Table 1 The inhibitory effect of different agents on tomato virus disease (CMV)

[0072]

[0073]

[0074] Field efficacy test

[0075] Field test on the efficacy of different pesticides in controlling tomato virus diseases

[0076] Experimental location: Tomato greenhouse in Weifang City, Shandong Province, with moderate water and fertilizer management.

[0077] Test reference: Guidelines for field efficacy tests of pesticides "Part 8: Fungicides for the control of tomato virus diseases";

[0078] Test target: Tomato virus disease (cucumber mosaic virus CMV).

[0079] Test crops, varieties and growth conditions: Tomato (hairy powder) was in the flowering and fruiting stage during the application of the pesticide and grew well.

[0080] Test drugs: Test drugs and dosages are shown in the table below.

[0081] Table 2 Test agents and dosage

[0082] Experimental treatment <![CDATA[For active ingredient (ga.i / hm 2 )]]> 12% Morpholino Hydrochloride·Scintillanil Suspension (3:1)) Preparation Example 1 50 Preparation Example 2 of 5.9% Morpholino Hydrochloride·Cinnamyl Aqueous Solution (5:0.9) 50 Preparation Example 3 of 4.3% morpholinoguanidine hydrochloride·sphenanthracene aqueous solution (2.8:1.5) 50 Preparation Example 4 of 15% Morpholino Hydrochloride·Cinnamyl Water Dispersible Granules (2:1) 50 5.9% Morpholino Hydrochloride·Cinnamyl Aqueous Solution (5:0.9) Comparative Example 1 100 4.3% morpholino hydrochloride·sphenanthracene aqueous solution (2.8:1.5) Comparative Example 2 100 15% Morpholino Hydrochloride·Sphenanthamide Water Dispersible Granules (2:1) Comparative Example 3 100 5% Morphoguanidine hydrochloride soluble solution 80

[0083] Experimental setup: The plots treated with each agent were randomly distributed in blocks, with protective rows around the plots. Each treatment was repeated 4 times, with a 20m 2 Use conventional spraying method and use a backpack high-pressure sprayer to spray the liquid medicine evenly on the front and back of the leaves, making sure it is wet but not dripping.

[0084] Investigation and statistical methods: The first spraying was carried out when the lesions first appeared (April 28, 2024), and the second spraying was carried out after an interval of 7 days (May 5, 2024), for a total of two sprayings.

[0085] The disease incidence was investigated 3 and 10 days after the last application of pesticide.

[0086] Five random sampling points were selected in each plot, and six plants were surveyed at each point. The total number of plants surveyed and the number of graded diseased plants were recorded in units of plants.

[0087] The grading method is as follows:

[0088] Grade 0: no symptoms;

[0089] Level 1: clear veins, light mosaic;

[0090] Level 3: mosaic of heart leaves and middle leaves;

[0091] Level 5: The heart leaves and middle leaves are mosaic, a few leaves are deformed, wrinkled or the plant is slightly dwarfed;

[0092] Level 7: Severe mosaic, most leaves are deformed, shrunken or the plant is dwarfed;

[0093] Level 9: Severe mosaic, obvious leaf deformity and linear leaves, severe dwarfing of the plant, and even death.

[0094] Calculation method of drug efficacy:

[0095] The disease index and control efficacy are calculated using the following formula:

[0096] Calculation method of drug efficacy:

[0097]

[0098] Test results and analysis:

[0099] Table 3 Field efficacy test results of different agents for controlling tomato virus diseases

[0100]

[0101]

[0102] Note: Lowercase letters represent significant differences at the 5% level.

[0103] Table 4 Field efficacy test results of different agents for controlling tomato virus diseases

[0104]

[0105] Note: Lowercase letters represent significant differences at the 5% level.

[0106] It can be seen from the field efficacy experiments in the above table that each of Preparation Examples 1 to 4 shows good control effects on tomato virus diseases, with good rapid effectiveness. 3 days after application, the control effects of 12% morphoguanidine hydrochloride·sphenanthracene suspension (3:1), 5.9% morphoguanidine hydrochloride·sphenanthracene aqueous solution (5:0.9), 4.3% morphoguanidine hydrochloride·sphenanthracene aqueous solution (2.8:1.5), and 15% morphoguanidine hydrochloride·sphenanthracene water dispersible granules (2:1) on tomato virus diseases were 69.83%, 71.01%, 71.46%, and 71.90%, respectively. Ten days after application, the control effects were improved to varying degrees. The control effects of 12% morpholino hydrochloride·sphenanthamide suspension (3:1), 5.9% morpholino hydrochloride·sphenanthamide aqueous solution (5:0.9), 4.3% morpholino hydrochloride·sphenanthamide aqueous solution (2.8:1.5) and 15% morpholino hydrochloride·sphenanthamide water dispersible granules (2:1) against tomato virus were 75.45%, 80.41%, 80.64% and 76.40%, respectively.

[0107] In summary, through indoor toxicity determination and field efficacy tests, it can be seen that the fungicide composition of the present invention has a good control effect on plant pathogenic bacteria (tomato virus disease), is safe for target crops, has significant control effect, is superior to a single agent in delaying the development of drug resistance and prolonging the effectiveness, can effectively reduce costs and reduce drug residues.

[0108] It should be noted that the embodiments described above are only used to explain the present application and do not constitute any limitation to the present application. The present application is described with reference to typical embodiments, but it should be understood that the words used therein are descriptive and explanatory words, rather than restrictive words. The present application may be modified as specified within the scope of the claims of the present application, and the present invention may be revised without departing from the scope and spirit of the present application. Although the present application described therein relates to specific methods, materials and embodiments, it does not mean that the present application is limited to the specific examples disclosed therein. On the contrary, the present application can be extended to all other methods and applications with the same functions.

[0109] The compounded acaricidal composition or the preparation thereof of the present invention has significant control effect, and is superior to a single agent in delaying the generation of drug resistance and prolonging the lasting effect. In addition, no compound agent was found to cause phytotoxicity to crops in the test, indicating that the acaricidal composition or preparation obtained can reduce production costs and use costs and is safe for crops when the acaricidal synergistic synergy is improved.

[0110] Although the present invention has been described in detail above with general instructions and specific implementation schemes, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A bactericidal composition containing morpholinoguanidine hydrochloride, characterized in that: The bactericidal composition comprises an active ingredient A, an active ingredient B and a biological enzyme preparation, wherein the active ingredient A is morpholino hydrochloride and the active ingredient B is cintamanilide or its acetate.

2. The bactericidal composition according to claim 1, characterized in that: The mass ratio of the active ingredient A to the active ingredient B is 1:20 to 20:1; Preferably, the mass ratio of the active ingredient A to the active ingredient B is 1:5 to 10:

1.

3. The bactericidal composition according to claim 1, characterized in that: The biological enzyme preparation is a mixture of saccharifying enzyme, urease, cellulase, phytase and protease.

4. The bactericidal composition according to claim 3, characterized in that: The mass ratio of the saccharifying enzyme, urease, cellulase, phytase and protease is 2:1:1:1:2, 3:1:1:1:1 or 2:1:1:2:

1.

5. The bactericidal composition according to claim 1, characterized in that: In addition to the active ingredients, the fungicidal composition also includes agriculturally acceptable auxiliary ingredients. In addition to the active ingredients, the fungicidal composition also includes agriculturally acceptable auxiliary ingredients, and the auxiliary ingredients include one or more of solvents, emulsifiers, wetting agents, dispersants, stabilizers, antifreeze agents, thickeners, disintegrants, defoaming agents, preservatives and fillers.

6. The bactericidal composition according to claim 1, characterized in that: The bactericidal composition can be prepared into a formulation form permitted in agriculture.

7. The bactericidal composition according to claim 6, characterized in that: The dosage form of the preparation is a soluble solution, emulsifiable concentrate, latex, dispersible liquid, ointment, aqueous solution, aqueous emulsion, microemulsion, suspension, dispersible oil suspension, wettable powder, or water-dispersible granule; Preferably, the preparation is in the form of an aqueous solution, an aqueous emulsion, a suspension, or a water-dispersible granule.

8. Use of the fungicidal composition according to any one of claims 1 to 7 for preventing and controlling plant viral diseases.

9. The use according to claim 8, characterized in that: The plants are eggplant, tomato, cucumber and tobacco.

10. The bactericidal composition according to claim 1, characterized in that: The fungicidal composition is applied to crops or crop growing areas to be controlled at an effective dose.