Breviscapine tablet

Abstract

The invention discloses a breviscapine tablet which is prepared from the following raw material medicines in parts by weight: 1-3 parts of breviscapine, 5-10 parts of ligusticum wallichii, 8-12 parts of corydalis tuber, 10-20 parts of radix curcumae, 10-20 parts of rose, 15-25 parts of angelica sinensis, 8-12 parts of prepared rehmannia root, 20-30 parts of fructus lycii and the like, and discloses a preparation method of the breviscapine tablet, and the breviscapine tablet can be used for treating sequelae of apoplexy caused by qi deficiency and blood stasis.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine research, and particularly relates to a breviscapine tablet, a preparation method of the breviscapine tablet, and application of the breviscapine tablet in preparing a medicine for treating sequelae of stroke. Background Art

[0002] The sequelae of stroke are the symptoms left after the stroke occurs and after treatment, which are called sequelae of stroke. Common sequelae of stroke include hemiplegia, muscle weakness, movement disorder, dysphagia, crooked corners of mouth, limb numbness, speech disorder, coughing when eating or drinking water, etc. Patients with sequelae of stroke need to actively undergo rehabilitation treatment and training, such as acupuncture, Chinese medicine, physical therapy, etc. can be selected for treatment. Muscle strength training, language training, sports training, etc. can also be carried out. The sequelae of stroke bring inconvenience to the patient's body and life to a certain extent, so active treatment and training are the key, and regular review is also required to avoid repeated stroke. Traditional Chinese medicine believes that the sequelae of stroke are mainly caused by qi deficiency and blood stasis, phlegm and dampness internal obstruction, liver and kidney yin deficiency, etc. 1. Qi deficiency and blood stasis: usually caused by emotional discomfort, the main symptoms include weakness in the limbs, fatigue, pale tongue, etc. Traditional Chinese medicine believes that it is necessary to treat it by replenishing qi and activating blood circulation. Commonly used medicines include ginseng soup, Taohong Siwu soup, etc. These medicines can replenish qi and blood, promote blood circulation, and thus improve the patient's symptoms. 2. Phlegm and dampness internal obstruction: It may be caused by spleen and stomach weakness, irregular diet, etc. The main symptoms include slurred speech, heavy head and light feet, dizziness, dry mouth, etc. Traditional Chinese medicine believes that phlegm and dampness internal obstruction needs to be treated by clearing heat and resolving phlegm, unblocking meridians and relieving pain. Commonly used medicines include Banxia Xiexin Decoction, Gegen Qinlian Decoction, etc., which can promote the smooth flow of qi, remove phlegm and resolve phlegm, and relieve the patient's discomfort. 3. Liver and kidney yin deficiency: It is usually caused by insufficient liver blood and insufficient kidney yin fluid. Patients may experience dizziness, headache, tinnitus, soreness of waist and knees, etc. Traditional Chinese medicine believes that liver and kidney yin deficiency needs to be treated by nourishing yin and kidney, calming the liver and reducing fire. Commonly used medicines include Liuwei Dihuang Pills, Tuiretang, etc., which can nourish yin and blood, calm the liver and reduce fire, and promote the recovery of the body. Among them, qi deficiency and blood stasis are the most common.

[0003] Breviscapus, also known as Breviscapus Asarum, is named for its flowers resembling a lantern and its roots resembling asarum, and is known as the "magic grass of southern Yunnan". Breviscapus was first clearly recorded in the "Southern Yunnan Materia Medica" written by Lan Mao, a medical expert in the Ming Dynasty. It is an annual herb of the genus Erigeron in the Asteraceae family. It is mainly distributed in the southwest of my country, especially in Yunnan, where the resources of Breviscapus medicinal materials are the most abundant, accounting for 95% of the total resources in the country, and has been protected by the National Geographic Product Mark. Breviscapus has the effect of activating blood circulation and improving blood supply. It is a crude extract of the traditional medicinal plant Breviscapus, which is officially named Erigeron short-courtyard scutellaria in the Flora of China. The main component of Breviscapus, scutellarin (also known as scutellarin B and wild scutellarin glycoside), has high medicinal value and high safety. Breviscapus can be used for cerebral vascular stasis, hemiplegia caused by stroke, obstruction of the heart vessels, chest pain and heart pain; sequelae of stroke, coronary heart disease, and angina pectoris with the above symptoms.

[0004] Due to the complexity of patients' conditions and the diversity of pathogenesis, single-ingredient breviscapine can no longer meet the changes in patients' conditions. Chinese herbal compound is designed under precise syndrome differentiation, targeting more complex pathogenesis and relatively certain symptoms. It is obtained by fully utilizing the advantages of syndrome differentiation and treatment in Chinese medicine and accumulating rich experience in long-term clinical practice. It provides clear learning and reference significance for future generations to prescribe and use medicines. Its standardized combination of the four properties and five flavors of the medicine has greatly improved the clinical efficacy of Chinese herbal prescriptions. In addition, modern research has found that the mechanism of action of Chinese herbal compound has the characteristics of multi-target and multi-level, which also provides new ideas and newer challenges for modern research. Summary of the invention

[0005] In view of this, the purpose of the present invention is to provide a breviscapine tablet and a preparation method thereof, so as to achieve the effect of treating stroke sequelae of qi deficiency and blood stasis syndrome and reducing the treatment cost.

[0006] The objective of the present invention is achieved through the following technical solutions:

[0007] The invention provides a breviscapine tablet. The breviscapine tablet is composed of the following raw materials in parts by weight: 1-3 parts of breviscapine, 5-10 parts of chuanxiong, 8-12 parts of yanhusuo, 10-20 parts of curcuma, 10-20 parts of rose, 15-25 parts of angelica, 8-12 parts of prepared rehmannia, 20-30 parts of wolfberry, 15-25 parts of tuckahoe, 14-20 parts of cassia twig, 5-10 parts of roasted liquorice, 10-20 parts of codonopsis, 12-20 parts of tangerine peel, 8-12 parts of trichosanthes, 5-10 parts of arisaema, 10-20 parts of calamus, 8-12 parts of curcuma, 5-10 parts of immature bitter orange and 15-25 parts of achyranthes bidentata.

[0008] The breviscapine tablets are composed of the following raw materials in parts by weight: 2 parts of breviscapine, 8 parts of chuanxiong, 10 parts of yanhusuo, 15 parts of curcuma, 15 parts of rose, 20 parts of angelica, 10 parts of rehmannia root, 25 parts of wolfberry, 20 parts of poria, 17 parts of cassia twig, 8 parts of roasted liquorice, 15 parts of codonopsis, 16 parts of tangerine peel, 10 parts of trichosanthes, 8 parts of arisaema, 15 parts of calamus, 10 parts of curcuma, 8 parts of immature bitter orange, and 20 parts of achyranthes bidentata.

[0009] The application of the Breviscapine tablets in the preparation of a medicine for treating stroke sequelae of Qi deficiency and blood stasis syndrome.

[0010] The preparation of the Breviscapine tablets comprises the following steps:

[0011] (1) weighing breviscapine and other Chinese herbal medicine slices according to proportion, crushing the other Chinese herbal medicine slices respectively, mixing them, soaking them in water, then decocting, combining, filtering, and collecting the filtrate;

[0012] (2) The filtrate obtained in step (1) is concentrated under reduced pressure to obtain an extract, which is vacuum dried, and scutellaria baicalensis, a wetting agent, and a sweetener are added to granulate the extract, which is then sieved through a 12-mesh sieve, dried, and tableted.

[0013] The breviscapine tablets are prepared by adding water and decocting twice in step (1), adding 10-15 times the amount of water for the first time and decocting for 1.5 hours, and adding 8-12 times the amount of water for the second time and decocting for 1.5 hours, and then combining the extracts.

[0014] The preparation step (2) of the Breviscapus breviscapus tablets is to vacuum dry the extract, and the vacuum drying conditions are: 60° C., -0.09 Mpa, and 15 h.

[0015] Patients with stroke sequelae of Qi deficiency and blood stasis syndrome usually present with symptoms such as fatigue, sallow or pale complexion, dizziness, etc. They are often accompanied by limb numbness, pain or difficulty in movement. These symptoms are mostly caused by poor blood circulation and blood stasis caused by Qi deficiency.

[0016] Qi deficiency and blood stasis syndrome is a pathological phenomenon in which both qi deficiency and blood stasis syndrome exist simultaneously. Since qi deficiency cannot push blood to the face, stroke patients with qi deficiency and blood stasis syndrome will have a pale complexion, or due to the slow movement of qi and blood in the face, blood vessels will be blocked over time, resulting in a dull and dull complexion. At the same time, qi deficiency can lead to decreased function of the internal organs, resulting in a reluctance to speak, fatigue, and physical drowsiness. Blood stasis in the chest and flanks will cause the blood vessels in the chest and flanks to be blocked, which will cause pain, and pain in the chest and flanks. When blood stasis is blocked, the tongue veins may also be blocked, resulting in a dark tongue or petechiae, etc., and accompanied by a deep, thin, slow, or stringy pulse.

[0017] The Neijing says in the Treatise on Regulating Menstruation: "Blood and Qi both flow upwards, this is a major syncope", and the Suwen says: "When the Yang Qi is very angry, the body will collapse, and the blood will flow upwards, causing a minor syncope". Therefore, Erigeron chinensis, Chuanxiong, Corydalis, Curcuma and Rose are used as the main medicines to invigorate Qi and activate blood circulation. In the Qing Dynasty, Cheng Zhongling's Medical Enlightenment: Identification of Aphasia in Stroke pointed out: "If the heart meridian is silent, the patient will be unconscious and not aware of others, or will have symptoms such as staring straight and shaking the head. The heart cannot be affected by evil, but if it is affected, it will be dangerous, and this is a fatal disease. If the cell network is affected by evil, the patient will be unconscious and awake from time to time, or laugh from time to time. If the spleen meridian is silent, the patient will understand human affairs, or the lips will be loose, the corners of the mouth will drool, and the speech will be cold and astringent. If the kidney meridian is silent, the patient will suffer from paralysis of the waist and feet, or deafness and nocturnal enuresis. This is the differentiation. Therefore, it is necessary to treat from the four aspects of the heart, liver, kidney and spleen. Angelica, Rehmannia root, Lycium barbarum, and Poria are used to nourish the liver and kidney, cinnamon twig and roasted licorice root to nourish the heart, and Codonopsis pilosula and tangerine peel to strengthen the spleen, which are all ministerial drugs; internal wind is caused by the imbalance of yin and yang in the internal organs. "Zhongfeng Zhenquan" says: "The nature of the five internal organs is violent. When the liver wood is rebellious, wind will arise. The extreme of the five emotions will all generate fire. When the flames rise, the wind will also move. Pushing it, the yin is deficient below and the yang floats above, then the wind is deficient and secretly fanned. The body fluid is damaged and the blood is not sufficient, then the wind is dry and rampant. "That is, extreme fire can generate wind, and blood deficiency and dryness can cause wind. When internal wind rotates, both Qi and fire will float, forcing blood to surge upward, causing a dangerous sign of stroke. Phlegm is divided into wind phlegm, hot phlegm, and damp phlegm. Wind phlegm is caused by the rotation of internal wind, which carries phlegm across the blood vessels, obstructing the heart and causing illness; hot phlegm is caused by the internal accumulation of phlegm and dampness. "Dan Xi's Heart Method · Stroke" says, "From now on, the northwest two directions are also affected by wind, but they are very rare. People in the southeast are mostly suffering from damp soil that produces phlegm, phlegm that produces heat, and heat that produces wind. Damp phlegm is often caused by qi deficiency, and is often seen in the recovery period or sequelae period of stroke. Because qi deficiency and damp phlegm block the meridians, symptoms such as hemiplegia and difficulty speaking are seen. Therefore, Trichosanthes kirilowii and Arisaema consanguineum are used to calm the wind and resolve phlegm, and Acorus calamus and Curcuma aromatica are used as adjuvants to open the orifices. Regarding the onset of stroke, Li Gao said that "the righteous qi is weak from the beginning." Qi deficiency can produce phlegm, and the lack of qi can cause blood circulation to stagnate; qi stagnation can turn into fire, and excessive fire can damage the yin and cause wind; qi reversal can affect blood circulation, and if blood As the qi goes up to the Yongqing orifice, the liver wind moves. Therefore, all qi deficiency, qi depression, qi stagnation, qi reversal are related to phlegm turbidity and blood stasis, which are the main pathogenesis of the disease. Therefore, Zhishi and Achyranthes bidentata are used to descend qi and stop reversal, guide the medicine downward, and restore limb function, which are all guiding drugs. The whole prescription contains breviscapine, Chuanxiong, Corydalis, Curcuma, Rose, Angelica, Rehmannia root, Lycium barbarum, Poria, cinnamon twig, roasted liquorice, Codonopsis, Tangerine peel, Trichosanthes, Arisaema, Acorus gramineus, Curcuma, Zhishi, Achyranthes bidentata, which can treat the sequelae of stroke belonging to the syndrome of qi deficiency and blood stasis. DETAILED DESCRIPTION

[0018] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the content of the present invention, those skilled in the art can make various changes or modifications to the present invention, but these equivalent forms fall within the scope limited by the appended claims of the application equally.

[0019] Example 1: Take 20g of breviscapine, 80g of chuanxiong, 100g of yanhusuo, 150g of turmeric, 150g of rose, 200g of angelica, 100g of rehmannia root, 250g of wolfberry, 200g of tuckahoe, 170g of cinnamon twig, 80g of licorice root, 150g of codonopsis, 160g of tangerine peel, 100g of trichosanthes, 80g of gallbladder arisaema, 150g of calamus, 100g of turmeric, 80g of immature bitter orange, and 200g of achyranthes bidentata, and the preparation comprises the following steps:

[0020] (1) Weighing breviscapine and other Chinese herbal medicine slices according to proportion, crushing the other Chinese herbal medicine slices respectively, mixing them, soaking them in water, and then decocting them twice, adding 12 times the amount of water for the first time and decocting them for 1.5 hours, and adding 10 times the amount of water for the second time and decocting them for 1.5 hours, combining the extracts, filtering, and collecting the filtrate;

[0021] (2) The filtrate obtained in step (1) is concentrated under reduced pressure to obtain an extract, and vacuum dried at 60° C., −0.09 MPa, and 15 h. Breviscapine, a wetting agent, and a sweetener are added, granulated, and then sieved through a 12-mesh sieve, dried, and tableted.

[0022] Example 2: Take 10g of breviscapine, 100g of chuanxiong, 80g of yanhusuo, 200g of turmeric, 100g of rose, 250g of angelica, 80g of prepared rehmannia, 300g of wolfberry, 150g of tuckahoe, 200g of cassia twig, 50g of licorice, 200g of codonopsis, 120g of tangerine peel, 120g of trichosanthes, 50g of gallbladder arisaema, 200g of calamus, 80g of turmeric, 100g of immature bitter orange, and 150g of achyranthes bidentata, and the preparation comprises the following steps:

[0023] (1) Weighing breviscapine and other Chinese herbal medicine slices according to proportion, crushing the other Chinese herbal medicine slices respectively, mixing them, soaking them in water, and then decocting them twice, adding 10 times the amount of water for the first time and decocting them for 1.5 hours, and adding 12 times the amount of water for the second time and decocting them for 1.5 hours, combining the extracts, filtering, and collecting the filtrate;

[0024] (2) The filtrate obtained in step (1) is concentrated under reduced pressure to obtain an extract, and vacuum dried at 60° C., −0.09 MPa, and 15 h. Breviscapine, a wetting agent, and a sweetener are added, granulated, and then sieved through a 12-mesh sieve, dried, and tableted.

[0025] Example 3: Take 30g of breviscapine, 50g of chuanxiong, 120g of yanhusuo, 100g of curcuma, 200g of rose, 150g of angelica, 120g of rehmannia root, 200g of wolfberry, 250g of tuckahoe, 140g of cinnamon twig, 100g of licorice root, 100g of codonopsis, 200g of tangerine peel, 80g of trichosanthes, 100g of cholerae arisaema, 100g of calamus, 120g of curcuma, 50g of immature bitter orange, and 250g of achyranthes bidentata, and the preparation comprises the following steps:

[0026] (1) Weighing breviscapine and other Chinese herbal medicine slices according to proportion, crushing the other Chinese herbal medicine slices respectively, mixing them, soaking them in water, and then decocting them twice, adding 15 times the amount of water for the first time and decocting them for 1.5 hours, and adding 8 times the amount of water for the second time and decocting them for 1.5 hours, combining the extracts, filtering, and collecting the filtrate;

[0027] (2) The filtrate obtained in step (1) is concentrated under reduced pressure to obtain an extract, and vacuum dried at 60° C., −0.09 MPa, and 15 h. Breviscapine, a wetting agent, and a sweetener are added, granulated, and then sieved through a 12-mesh sieve, dried, and tableted.

[0028] Example 4: Pharmacodynamics Study

[0029] Effect on the ability of mice to tolerate hypoxia at normal pressure: 80 mice were taken, half male and half female, with a body weight of 20±2g. They were randomly and evenly divided into 4 groups, and were respectively gavaged with high and low doses of the breviscapus tablets prepared in Example 1 of the present invention (equivalent to the crude drug amount of 1g / l0g and 0.5g / l0g, respectively), Huatuo Zaizao Pills suspension (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd., National Medicine Standard Z44020748, 0.2g / ml, 0.2ml / 10g), and the same volume of normal saline, once a day for 5 consecutive days. 1h after the last administration, the mice were placed in a sealed small wide-mouth bottle (150ml). Before the mice were placed, the turbid gas in the small wide-mouth bottle was fully discharged, and vaseline was applied to the bottle. After the mice were placed, they were immediately sealed, and the time from the mice being placed in the bottle to death was recorded. The death of mice was marked by respiratory arrest, and the laboratory temperature was 28°C. The results are shown in Table 1.

[0030] Table 1 Effect of the present invention on the ability of mice to tolerate hypoxia at normal pressure

[0031] Grouping Survival time (min) Normal saline group 19.45±3.56 Huatuo Zaizao Pills <![CDATA[23.87±2.98 # ]]> Example 1 Low-dose group of the present invention <![CDATA[22.46±3.14 # ]]> Example 1 High dose group of the present invention <![CDATA[25.69±3.32 ## ]]>

[0032] Compared with the saline group: # P<0.05, ## P<0.01

[0033] It can be seen from the above table that the high-dose group of Example 1 of the present invention can significantly prolong the survival time of mice in a closed environment at normal pressure (P<0.01), the low-dose group of Example 1 of the present invention and the Huatuo Zaizao Pills group can prolong their survival time (P<0.05), and the high-dose group of Example 1 of the present invention has a better effect than the positive drug group.

[0034] Effect on adrenaline-induced microcirculatory disorders in mice: 80 male mice, half male and half female, weighing 20±2g, were randomly and evenly divided into 4 groups, and high and low doses of the breviscapus tablets prepared in Example 1 of the present invention (equivalent to the crude drug amount of 1g / l0g and 0.5g / l0g, respectively), Huatuo Zaizao Pills suspension (Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd., National Medicine Standard Z44020748, 0.2g / ml, 0.2ml / 10g), and the same volume of normal saline were respectively administered once a day for 5 consecutive days. After the last administration, 35mg / kg of sodium pentobarbital was administered ip. The mice were anesthetized, the right ears of the mice were dehaired, and then shampoo oil was applied. The right ears of the mice were attached to a glass slide, and the microcirculation of the mice was observed under a microscope with a cold light source lamp as the light source and transmitted light. Before adrenaline was given, the blood flow was linear, and then 10 mg / kg adrenaline was given to the mice by iv, which was completed within 10 seconds. The blood flow of the mice was observed 3 minutes after adrenaline was given. The results are shown in Table 2.

[0035] Table 2 Effect of the present invention on adrenaline-induced auricular microcirculation disorders in mice

[0036]

[0037] It can be seen from the above table that the high-dose group of Example 1 of the present invention and the Huatuo Zaizao Pills group can significantly improve microcirculation disorders (p<0.01), the low-dose group of Example 1 of the present invention can improve microcirculation disorders (P<0.05), and the high-dose group of Example 1 of the present invention has a better effect than the positive drug group.

[0038] Example 5: Clinical study

[0039] General information: The subjects of this study were 80 patients with sequelae of stroke with qi deficiency and blood stasis who were treated from January 2023 to January 2024, and were divided into 40 cases in each of the Example 1 group and the control group. The age of the Example 1 group was 60-82 years old, with a calculated mean of 73.58 years old, 24 male patients, and 16 female patients. The age of the observation group was 64-81 years old, with a calculated mean of 72.65 years old, 22 male patients, and 18 female patients. Comparing the basic information of the subjects in the observation group and the control group, it was found that there was no statistical difference in age, gender, etc. (P>0.05).

[0040] Inclusion criteria: ① All subjects signed the informed consent form and participated voluntarily. ② All patients participating in the study were in normal mental state and could cooperate with the operation. Exclusion criteria: ① Those with severe renal insufficiency were excluded. ② Those with other blood diseases and major infections were excluded.

[0041] TCM diagnostic criteria: Patients who have suffered a stroke and then developed stroke sequelae are classified as patients with qi deficiency and blood stasis syndrome, usually manifested by fatigue, sallow or pale complexion, dizziness, etc. Often accompanied by limb numbness, pain or difficulty in movement.

[0042] Treatment method: For the subjects in the control group, the medical staff chose to apply conservative treatment intervention. According to the actual situation of the patients, the patients were guided to take aspirin enteric-coated tablets (manufacturer: Hainan Bikai Pharmaceutical Co., Ltd.; approval number: National Medicine Standard H46020480), once a day, each dose of 100 mg. During the same period, nimodipine soft capsules (manufacturer: Shanxi Jinxin Shuanghe Pharmaceutical Co., Ltd.; approval number: National Medicine Standard H19991416) were taken three times a day, each dose of 2 mg, and atorvastatin calcium tablets [manufacturer: Beijing Jialin Pharmaceutical Co., Ltd.; approval number: National Medicine Standard H19990258] were taken once a day in the evening, each dose of 10 mg. If the patient is accompanied by high blood pressure, antihypertensive drugs should be combined for treatment intervention. If the patient is accompanied by diabetes, hypoglycemic drugs should be combined for treatment intervention. In the later stage, the therapeutic dose of the drug can be appropriately adjusted according to the actual situation of the patient. For the experimental subjects of the observation group of Example 1, the medical staff chose to use the Breviscapus Tablets prepared in Example 1 for treatment intervention. According to the actual situation of the patient, the patient was given Breviscapus Tablets for treatment intervention, and the daily dosage consisted of Breviscapus 2g, Chuanxiong 8g, Corydalis 10g, Curcuma 15g, Rose 15g, Angelica 20g, Rehmannia glutinosa 10g, Lycium barbarum 25g, Poria 20g, Cinnamon twig 17g, Rhizoma Licorice 8g, Codonopsis pilosula 15g, Tangerine peel 16g, Trichosanthes 10g, Arisaema cinerea 8g, Acorus gramineus 15g, Curcuma 10g, Citrus aurantium 8g, Achyranthes bidentata 20g. Take it twice a day, morning and evening.

[0043] Efficacy criteria: Significantly effective: After treatment, the symptoms of the subjects were significantly improved, and no adverse reactions occurred; Effective: After treatment, the symptoms of the subjects were partially improved, and slight adverse reactions occurred; Ineffective: The subjects did not meet the above two criteria, and the condition did not improve or worsened. The results are shown in Table 3.

[0044] Quality of life measurement: After the treatment service, the SF-36 scale was used to evaluate the quality of life of the subjects. The specific measurement items included psychological function score, material life status score, and social function score. The overall comprehensive score was 0-100 points. The results are shown in Table 4.

[0045] Table 3 Comparison of total effective rate between the two groups

[0046] Grouping Significant effect efficient invalid Effectiveness (%) Control group 13 18 9 77.5 Example 1 Group 21 16 3 <![CDATA[92.5 * ]]>

[0047] Compared with the control group * P<0.05, **P<0.01

[0048] Table 4 Comparison of quality of life measurements

[0049]

[0050] Compared with before treatment: # P<0.05, ## P<0.01

[0051] Results: After the treatment, the total effective rate of the two groups of subjects was compared. The total effective rate of the observation group (95.00%) was higher than that of the control group (72.50%) (P < 0.05). The quality of life scores of the two groups of subjects were compared. The psychological function score of the observation group was (87.45 ± 7.27) points, the material life status score was (84.21 ± 7.09) points, and the social function score was (78.39 ± 5.67) points, which were higher than the psychological function score (76.31 ± 8.98) points, the material life status score (74.72 ± 6.42) points, and the social function score (69.21 ± 6.46) points of the control group (P < 0.05). This shows that the present invention has a good effect on patients with stroke sequelae belonging to the Qi deficiency and blood stasis syndrome, and the effect is better than that of the control group.

[0052] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A breviscapus breviscapus tablet, characterized in that: The breviscapine tablets are composed of the following raw materials in parts by weight: 1-3 parts of breviscapine, 5-10 parts of chuanxiong, 8-12 parts of yanhusuo, 10-20 parts of curcuma, 10-20 parts of rose, 15-25 parts of angelica, 8-12 parts of rehmannia root, 20-30 parts of wolfberry, 15-25 parts of tuckahoe, 14-20 parts of cassia twig, 5-10 parts of roasted liquorice, 10-20 parts of codonopsis pilosula, 12-20 parts of tangerine peel, 8-12 parts of trichosanthes, 5-10 parts of arisaema, 10-20 parts of calamus, 8-12 parts of curcuma, 5-10 parts of immature bitter orange, and 15-25 parts of achyranthes bidentata.

2. The Breviscapus breviscapus tablet according to claim 1, characterized in that: The breviscapine tablets are composed of the following raw materials in parts by weight: 2 parts of breviscapine, 8 parts of chuanxiong, 10 parts of yanhusuo, 15 parts of curcuma, 15 parts of rose, 20 parts of angelica, 10 parts of rehmannia root, 25 parts of wolfberry, 20 parts of poria, 17 parts of cinnamon twig, 8 parts of roasted liquorice, 15 parts of codonopsis, 16 parts of tangerine peel, 10 parts of trichosanthes, 8 parts of arisaema, 15 parts of calamus, 10 parts of curcuma, 8 parts of immature bitter orange, and 20 parts of achyranthes bidentata.

3. Use of the Breviscapine Tablets as claimed in claim 1 in the preparation of a drug for treating stroke sequelae of Qi deficiency and blood stasis syndrome.

4. The Breviscapus breviscapus tablet according to claim 1, characterized in that: The preparation comprises the following steps: (1) weighing breviscapine and other Chinese herbal medicine slices according to proportion, crushing the other Chinese herbal medicine slices respectively, mixing them, soaking them in water, then decocting, combining, filtering, and collecting the filtrate; (2) The filtrate obtained in step (1) is concentrated under reduced pressure to obtain an extract, which is vacuum dried, and scutellaria baicalensis, a wetting agent, and a sweetener are added to granulate the extract, which is then sieved through a 12-mesh sieve, dried, and tableted.

5. The Breviscapus breviscapus tablet according to claim 4, characterized in that: In the preparation step (1), water is added and boiled twice, 10-15 times the amount of water is added for the first time and boiled for 1.5 hours, and 8-12 times the amount of water is added for the second time and boiled for 1.5 hours, and the extracts are combined.

6. The Breviscapus breviscapus tablet according to claim 4, characterized in that: Preparation step (2) vacuum drying the extract, the vacuum drying conditions are: 60°C, -0.09Mpa, 15h.

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