External parasite-expelling traditional Chinese medicine extract dry scattering powder for animals

Abstract

The invention discloses externally-applied parasite-expelling traditional Chinese medicine extract dry powder for animals, which belongs to the technical field of parasite expelling and comprises a traditional Chinese medicine extract and a dispersion carrier. The traditional Chinese medicine extract is prepared by mixing one or more of croton seed extract, rhizoma smilacis glabrae extract, cortex meliae extract, flos genkwa extract, radix sophorae flavescentis extract, fructus cnidii extract, chaulmoogratree seed extract, cortex dictamni extract, radix stemonae extract, radix euphorbiae lantu extract, gelsmium elegans extract, desmodium triquetrum extract, pepper extract, pepper extract, spina gleditsiae extract and veratrum nigrum extract in any proportion. The composition is used for preventing and killing ectoparasites such as scabies, lice, fleas and ticks of pets such as pigs, cattle, sheep, poultry, dogs and cats, can also be used for feeding places to prevent repeated infection of parasites, and in addition, the parasite expelling components are pure traditional Chinese medicine extracts, so that the problem of drug residues and the problem of drug resistance of chemical drugs are avoided, and the composition is safe and reliable. The medicine is directly spread on animal body surfaces and in a feeding environment, so that the medicine is labor-saving, safe, environment-friendly and beneficial to human health.

Description

Technical Field

[0001] The invention relates to the technical field of anthelmintic, and more particularly to a dry powder of an anthelmintic Chinese medicine extract for external use on animals. Background Art

[0002] It is very important to eliminate external parasites in the animal breeding process. The methods currently used are: 1. injecting anthelmintics into animals; 2. giving animals anthelmintics orally; 3. using anthelmintics to bathe animals or spray anthelmintics directly on the animal's body surface; 4. applying anthelmintics on the animal's skin surface.

[0003] The above deworming methods all have certain problems: injecting anthelmintics into animals requires restraining cattle, sheep, pigs, dogs, cats, and poultry, especially large animals such as cattle, sheep, and pigs. If the animals are not restrained, the staff are prone to being attacked by the animals, which poses a greater risk. Although poultry such as chickens, ducks, and geese are relatively small and safe, they are large in number, and injecting drugs one by one is time-consuming and laborious. In addition, there is the risk of drug residues when injecting anthelmintics; oral administration of anthelmintics to animals has a "first-pass liver effect" and low bioavailability, resulting in drug waste and the risk of drug residues; medicated baths and spraying are suitable for the warm spring and summer seasons, while the temperature is lower in autumn and winter, which can easily cause colds in livestock and poultry; rubbing medication is suitable for a small number of individual animals, such as pets such as dogs, cats, and rabbits, but is not suitable for large-scale breeding of cattle, sheep, pigs, and poultry. Summary of the invention

[0004] 1. Technical problems to be solved

[0005] At present, there is only one anthelmintic drug with Chinese medicinal ingredients that can be used for external use in animals in the "Pharmacopoeia of the People's Republic of China (2020 Edition)", which is "Caesalpinia scabra". The ingredients are: 120g of wolfsbane, 120g of pig tooth soap, 30g of croton, 9g of realgar, and 5g of light powder. The method of use is: heat the vegetable oil, add the medicine to it, adjust it into a flowing paste, and apply it to the affected area. It needs to be applied one by one or one by one, so this drug is not suitable for large-scale breeding enterprises. In addition, the main component of realgar is arsenic disulfide (As2S2), and the main component of light powder is mercurous chloride (Hg2Cl2). The arsenic and mercury contained in the two medicines are heavy metals and are toxic. There is a risk of residual when used on livestock and poultry. Today, when food safety is increasingly valued, it is no longer recommended to use these two medicines for food animals. Therefore, it is becoming more and more urgent to develop a veterinary drug that meets food safety requirements, can well control external parasites of livestock and poultry, and is easy to use.

[0006] 2. Technical solution

[0007] To solve the above problems, the present invention adopts the following technical solutions:

[0008] The invention discloses a dry powder of an external anthelmintic Chinese medicine extract for animals, comprising a Chinese medicine extract and a dispersion carrier.

[0009] The Chinese medicine extract is prepared by mixing one or more of the extracts of croton, smilax glabra, chinaberry bark, genkwa, sophora flavescens, cnidium monnieri, radix daphne, cortex divaricata, stemonae, wolfsbane, gelsemium scabra, caltrop, zanthoxylum bungeana, capsicum, thorn of gleditsia, and veratrum in any proportion.

[0010] Furthermore, the dispersion carrier is talcum powder.

[0011] Furthermore, the weight of the Chinese herbal extract accounts for 10%-50%, and the weight of the dispersion carrier accounts for 50%-90%.

[0012] A method for preparing dry powder of an animal external anthelmintic Chinese medicine extract comprises the following steps:

[0013] S1. Pre-treat the raw materials of Chinese herbal medicine extracts, remove the low-efficacy parts of Croton, Melia azedarach, Smilax glabra, Fructus sylvestris, Fructus cnidii and Sophora flavescens, and then dry them to obtain the extracts and low-efficacy raw materials, and select the raw materials of the remaining Chinese herbal medicine extracts, preferably grind the high-quality raw materials to obtain dry powder raw materials, and crush the low-quality raw materials to obtain auxiliary raw materials.

[0014] S2, the extract is crushed and sieved, and then alcohol-extracted to obtain a Chinese medicine extract.

[0015] S3. Prepare two components of talcum powder, one of which is a group of talcum powder, Chinese medicine extract and dry powder raw materials, which are mixed and ground, and then sieved to obtain external dry powder; the remaining group of talcum powder, low-efficacy raw materials and auxiliary raw materials are mixed and ground, and then sieved to obtain environmental insect repellent dry powder.

[0016] Further, the following steps are included: according to the operation steps in S1,

[0017] S101, solvent extraction, using ethanol as the extraction solvent, putting the pretreated extract into an extraction tank, and adding an appropriate amount of ethanol solvent.

[0018] S102, heating the extraction tank to boil the solvent, and promoting the dissolution of the active ingredients through a stirring or reflux device.

[0019] S103, after a certain period of extraction, stop heating, wait for the solution to cool down, and separate the extract from the medicinal residue through a filtering device.

[0020] S104, concentrating the extract to obtain a Chinese medicine extract.

[0021] Further, the method comprises the following steps: according to the operation steps in S101, the ethanol concentration range is 70% to 95%.

[0022] Further, the method comprises the following steps: according to the operation steps in S104, the extract is concentrated by vacuum distillation, wherein the temperature is 75-85 degrees Celsius and the pressure is 1.33 to 3.33 kPa.

[0023] A method for using a dry powder of an animal external anthelmintic Chinese medicine extract comprises the following steps:

[0024] S1. First, apply the topical dry powder directly to the parasitized animals, and adjust the dosage according to the type of animal.

[0025] S2. For poultry, since the feathers are thick and dense, it is not effective to sprinkle the powder directly on the feathers. You can sprinkle the powder on the feathers and then rub it onto the skin in the opposite direction of the feathers. Apply the external dry powder under the wings.

[0026] S3. In seasons with severe external parasites, animals and poultry may be treated repeatedly within 10-14 days.

[0027] S4. After the farm and sand bath are disinfected, spread dry powder for external use for efficient deworming and insecticide. The sand bath is mixed with dry powder for external use to improve the deworming effect.

[0028] S5. Daily disinfection: In order to ensure the insect repellent and insecticidal effect, spread the environment with insect repellent dry powder in the morning and evening.

[0029] Further, the method comprises the following steps: according to the operation steps in S1-S5, the usage amount is 50-200g for cattle, 25-100g for sheep and goats, 25-50g for pigs, 3-5g for poultry, and 5-10g for dogs and cats.

[0030] Further, the method comprises the following steps: according to the operating steps in S1-S5, in the case of severe parasites, the drug dosage can be increased by 10%-50% according to the body weight and the degree of infection, and the animals and poultry can be treated repeatedly within 10-14 days in the season when the external parasites are serious. When using sand bath disinfection, the dosage is 10 parts by weight of sand plus 1 part by weight of external dry powder for mixing, and the usage amount for farm disinfection is 50-150g per square meter.

[0031] 3. Beneficial effects

[0032] Compared with the prior art, the advantages of the present invention are:

[0033] The invention is used for preventing and eliminating ectoparasites such as scabies, lice, fleas, ticks, etc. of pets such as pigs, cattle, sheep, poultry, dogs and cats, and can also be used in breeding places to prevent repeated parasite infection. In addition, the anthelmintic component of the invention is a pure Chinese medicine extract, and there is no problem of drug residue and no problem of chemical drug resistance. The drug can be directly sprinkled on the animal body surface and the breeding environment, which saves labor and energy, is safe and environmentally friendly, and is beneficial to human health. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present invention will be described clearly and completely below in combination with the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] Embodiment 1: A dry powder of Chinese herbal extract for external use as an animal anthelmintic, comprising a Chinese herbal extract and a dispersion carrier, wherein the Chinese herbal extract is prepared by mixing one or more of the extracts of croton, smilax glabra, chinaberry bark, genkwa, sophora flavescens, cnidium monnieri, daphne sylvestris, radix divaricata, radix stemonae, wolfsbane, gelsemium elegans, gourd tea, prickly ash, capsicum, thorn of sapodilla, and veratrum in any proportion, the dispersion carrier is talcum powder, the weight of the Chinese herbal extract accounts for 10%-50%, the weight of the dispersion carrier accounts for 50%-90%, the function of croton: ulcers, treatment of: malignant ulcers, scabies, the active ingredient is crotonin (C 10 H 13 N5O5), Melia azedarach bark function: insecticide, tinea treatment Indications: abdominal pain caused by worm accumulation, scabies The active ingredient is neem extract (C 30 H 38 O 11 ), Smilax glabra function: dehumidification, detoxification Indications: carbuncle, scabies The active ingredient is astilbin (C 21 H 22 O 11 ), Dafengzi function: attacking poison and killing insects. Indications: scabies, bedsores and itching. The active ingredient is Dafengzi oil. Wolfsbane function: killing insects. Indications: scabies. The active ingredient is not yet clear. Stemona function: killing insects. Indications: scabies, body lice. The active ingredient is not yet clear. Cnidium monnieri function: killing insects and relieving itching. Indications: eczema, itching. The active ingredient is osthole (C 15 H 16 O3), Sophora flavescens function: clearing away heat, drying dampness and killing insects Indications: scabies The active ingredient is matrine (C 15 H 24 N2O) and oxymatrine (C 15 H 24N2O2), talcum powder appears as white or grayish white crystalline fine powder, is odorless, tasteless, delicate and lubricated, easily adheres to the skin, feels slippery in contact with the skin, can make the skin slippery and dry, can be used as a skin protectant, has good fluidity and adsorption, uses talcum powder as a dispersion carrier, can make the drug mix evenly, and can make the drug adhere well to the hair and skin of animals, in addition, talcum powder also has a good auxiliary therapeutic effect on skin eczema, itching, tissue fluid exudation and other diseases.

[0036] A method for preparing dry powder of an animal external anthelmintic Chinese medicine extract comprises the following steps:

[0037] S1. Pre-treat the raw materials of Chinese herbal medicine extracts, wherein the low-efficacy parts of Croton, Melia azedarach, Smilax glabra, Fructus sylvestris, Fructus cnidii and Sophora flavescens are removed, and then dried to obtain the extracts and low-efficacy raw materials, and the remaining raw materials of Chinese herbal medicine extracts are selected, and the high-quality raw materials are preferably ground to obtain dry powder raw materials, and the low-quality raw materials are crushed to obtain auxiliary raw materials, S101. Solvent extraction, using ethanol as the extraction solvent, the pre-treated extracts are loaded into an extraction tank, and an appropriate amount of ethanol solvent is added, S102, heating the extraction tank to make the solvent boil, and promoting the dissolution of the effective ingredients by stirring or reflux device, S103, after extraction for a certain period of time, stopping heating, and waiting for After the solution is cooled, the extract is separated from the drug residue by a filtering device, S104, the extract is concentrated to obtain a Chinese medicine extract, the ethanol concentration range is 70% to 95%, and the extract concentration treatment is achieved by reduced pressure distillation, wherein the temperature is 75-85 degrees Celsius and the pressure is 1.33 to 3.33 kPa, S2, the extract is crushed and sieved, and alcohol extraction is performed to obtain a Chinese medicine extract, S3, two components of talcum powder are prepared, one group of talcum powder, Chinese medicine extract and dry powder raw materials are mixed and ground, and external dry powder is obtained after sieving, and the remaining group of talcum powder, low-efficacy raw materials and auxiliary raw materials are mixed and ground, and environmental insect repellent dry powder is obtained after sieving.

[0038] A method for using a dry powder of an animal external anthelmintic Chinese medicine extract comprises the following steps:

[0039] S1. First, apply the external dry powder directly to the parasitized animals, and adjust the dosage according to the type of animal. S2. For poultry, because the feathers are thick and dense, it is not effective to sprinkle directly on the feathers. You can sprinkle it on the feathers and then rub it on the skin against the direction of the feathers, and apply the external dry powder under the wings. S3. In the season when external parasites are serious, animals and poultry can be treated repeatedly within 10-14 days. S4. After the farm and sand bath are completed and disinfected, spread the external dry powder for efficient insect repellent and insecticide. The sand bath is mixed with the external dry powder to improve the insect repellent effect. S5. In daily disinfection, in order to ensure the insect repellent and insecticide effect, spread the environmental insect repellent dry powder in the morning and evening. The drug can be directly and evenly sprinkled on the epidermis and hair of cattle, sheep, pigs and other animals. Dosage: 50-200g for cattle , 25-100g for sheep and goats, 25-50g for pigs. For poultry, because the feathers are thick and dense, it is not effective to sprinkle directly on the feathers. You can sprinkle on the feathers and then rub them onto the skin against the direction of the feathers, but be careful to avoid contact with the mucous membrane. Dosage: Apply the drug under the wings, 3-5g for each poultry (chicken, duck and goose). For pets such as dogs and cats, in order to obtain better results, use a dose of 5-10g per dog, and use a brush to apply the drug to the deep layer of hair on the neck, back and other parts of the body. Dosage: 10-50g for large dogs, 2-10g for small dogs and cats. In case of severe parasites, the drug dosage can be increased by 10%-50% according to body weight and degree of infection. In the season when external parasites are serious, the treatment of animals and poultry can be repeated within 10-14 days.

[0040] In order to further illustrate the beneficial effects of the present invention, the inventor selected two anthelmintics, selected the name of cajiesan, which is briefly described as the first anthelmintic, and selected the name of anthelmintic powder, which is briefly described as the second anthelmintic, and selected the all-natural anthelmintic prepared by the present invention, and compared the anthelmintic effect, duration and course of treatment, and obtained the following data, as shown in Table 1:

[0041] Table 1 Experimental data table

[0042] Insect repellent effect Deworming duration Use treatment course First antiparasitic drug better 3-5 days Three courses of treatment Second antiparasitic drug Poor 1-3 days Three courses of treatment Example 1 good 7-14 days Two courses of treatment

[0043] Based on the above experimental data, Example 1 is used to prevent and eliminate scabies, lice, fleas, ticks and other external parasites of pets such as pigs, cattle, sheep, poultry, dogs and cats, and can also be used in breeding places to prevent repeated parasite infection. In addition, the anthelmintic component of the present invention is a pure Chinese medicine extract, and there is no problem of drug residue or chemical drug resistance. The drug can be directly sprinkled on the animal surface and the breeding environment, which saves labor and effort, is safe and environmentally friendly, and is beneficial to human health.

[0044] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and improved concepts of the present invention within the technical scope disclosed by the present invention, and they should be covered by the protection scope of the present invention.

Claims

1. A dry powder of an animal external anthelmintic Chinese medicine extract, characterized in that: Including Chinese herbal medicine extracts and dispersion carriers; The Chinese medicine extract is prepared by mixing one or more of the extracts of croton, smilax glabra, chinaberry bark, genkwa, sophora flavescens, cnidium monnieri, radix daphne, cortex divaricata, stemonae, wolfsbane, gelsemium scabra, caltrop, zanthoxylum bungeana, capsicum, thorn of gleditsia, and veratrum in any proportion.

2. The dry powder of the Chinese medicine extract for external use for animals for anthelmintic application according to claim 1, characterized in that: The dispersion carrier is talcum powder.

3. The dry powder of the Chinese medicine extract for external use as an animal anthelmintic according to claim 1, characterized in that: The weight of the Chinese herbal extract accounts for 10%-50%, and the weight of the dispersion carrier accounts for 50%-90%.

4. A method for preparing a dry powder of an animal external anthelmintic Chinese medicine extract, characterized in that: The following steps are involved: S1. Pre-treating the raw materials of Chinese herbal medicine extracts, wherein the low-efficacy parts of Croton, Melia azedarach, Smilax glabra, Fructus dasyphyllae, Fructus cnidii and Sophora flavescens are removed, and then dried to obtain the extracts and low-efficacy raw materials, and the remaining raw materials of Chinese herbal medicine extracts are selected, and high-quality raw materials are preferably ground to obtain dry powder raw materials, and low-quality raw materials are crushed to obtain auxiliary raw materials; S2, crushing and sieving the extract, and performing alcohol extraction to obtain a Chinese medicine extract; S3. Prepare two components of talcum powder, one of which is a group of talcum powder, Chinese medicine extract and dry powder raw materials, which are mixed and ground, and then sieved to obtain external dry powder; the remaining group of talcum powder, low-efficacy raw materials and auxiliary raw materials are mixed and ground, and then sieved to obtain environmental insect repellent dry powder.

5. The method for preparing a dry powder of an external anthelmintic Chinese medicine extract for animals according to claim 4, characterized in that: The following steps are included: According to the operation steps in S1, S101, solvent extraction, using ethanol as the extraction solvent, putting the pretreated extract into an extraction tank, and adding an appropriate amount of ethanol solvent; S102, heating the extraction tank to boil the solvent, and promoting the dissolution of the active ingredient by stirring or reflux device; S103, after a certain period of extraction, stop heating, wait for the solution to cool, and separate the extract from the medicinal residue through a filtering device; S104, concentrating the extract to obtain a Chinese medicine extract.

6. The method for preparing a dry powder of an external anthelmintic Chinese medicine extract for animals according to claim 4, characterized in that: The following steps are involved: According to the operation steps in S101, the ethanol concentration ranges from 70% to 95%.

7. The method for preparing a dry powder of an external anthelmintic Chinese medicine extract for animals according to claim 4, characterized in that: The following steps are involved: According to the operation steps in S104, the extract concentration treatment is achieved by reduced pressure distillation, wherein the temperature is 75-85 degrees Celsius and the pressure is 1.33 to 3.33 kPa.

8. A method for using a dry powder of an animal external anthelmintic Chinese medicine extract, characterized in that: The following steps are involved: S1. First, apply the topical dry powder directly to the parasitized animals, and adjust the amount of powder to be used according to the type of animal; S2. For poultry, since the feathers are thick and dense, it is not effective to sprinkle directly on the feathers. You can sprinkle on the feathers and then rub it against the direction of the feathers onto the skin. Apply the external dry powder under the wings. S3. In seasons with severe external parasites, animals and poultry may be treated repeatedly within 10-14 days; S4. After the farm and sand bath are disinfected, the external dry powder is spread for efficient insect repelling and killing, wherein the sand bath is mixed with the external dry powder to improve the insect repelling effect; S5. Daily disinfection: In order to ensure the insect repellent and insecticidal effect, spread the environment with insect repellent dry powder in the morning and evening.

9. The method for using the dry powder of the Chinese medicine extract for external use as an animal anthelmintic according to claim 8, characterized in that: The method comprises the following steps: according to the operation steps in S1-S5, the usage amount is 50-200g for cattle, 25-100g for sheep and goats, 25-50g for pigs, 3-5g for poultry, and 5-10g for dogs and cats.

10. The method for using the dry powder of the Chinese medicine extract for external use as an animal anthelmintic according to claim 8, characterized in that: The method comprises the following steps: according to the operation steps in S1-S5, the dosage can be increased by 10%-50% according to the body weight and the degree of infection in the case of serious parasites, the treatment of animals and poultry can be repeated within 10-14 days in the season when the external parasites are serious, when the sand bath is used for disinfection, the dosage is 10 parts by weight of sand plus 1 part by weight of external dry powder for mixing, and the dosage for farm disinfection is 50-150g per square meter.