Laser ablation device based on multiple spatial focuses and laser diagnosis and treatment integrated device

Abstract

The invention provides a laser ablation device based on multiple spatial focuses and a laser ablation diagnosis and treatment integrated device based on multiple spatial focuses. The laser ablation device comprises a treatment laser module, a light splitting module, a light modulation module, an optical fiber coupling module, an optical fiber array and a focusing micro-lens array which are sequentially connected through a light path. The treatment laser module is used for emitting treatment laser; the light splitting module divides the treatment laser into multiple paths of branch laser; the light modulation module carries out independent power regulation and control on each branch laser; the optical fiber coupling module is used for coupling each branch laser into each optical fiber branch in the optical fiber array and transmitting the laser to the focusing micro-lens array; each optical fiber branch corresponds to one focusing micro lens; the focusing micro-lens array is used for spatially focusing multiple paths of treatment laser to focus positions of lesion tissues for ablation treatment; the technical scheme can be used for ablation of various irregular pathological tissues, the ablation range is controllable, ablation is thorough, and surrounding healthy tissues are prevented from being damaged.

Description

Technical Field

[0001] The present application relates to the technical field of laser treatment equipment, and in particular to a laser ablation device based on spatial multi-focus and a laser ablation diagnosis and treatment integrated device based on spatial multi-focus. Background Art

[0002] At present, the use of laser ablation technology to treat diseased tissues has been increasingly used. When using laser to ablate diseased tissues, various irregular diseased tissues are often encountered. The irregularities in the internal characteristics and external shapes of these diseased tissues pose great challenges to diagnostic screening or ablation treatment.

[0003] When using conventional laser ablation technology to ablate these irregular tissues, there are problems such as difficulty in controlling the ablation range, incomplete ablation, and easy damage to surrounding healthy tissues. Especially when ablating diseased tissues in the body, the limited operating space limits the ablation range and accuracy, affecting the treatment effect of laser ablation. Summary of the invention

[0004] The purpose of the present application is to solve one of the above-mentioned technical defects and to provide a laser ablation device based on spatial multi-focus and an integrated laser ablation diagnosis and treatment device based on spatial multi-focus, which can improve the therapeutic effect of laser ablation.

[0005] A laser ablation device based on spatial multi-focus, comprising: a treatment laser module, a light splitting module, a light modulation module, a fiber coupling module, a fiber array, and a focusing microlens array, which are sequentially connected through an optical path;

[0006] The therapeutic laser module is used to emit therapeutic laser;

[0007] The light splitting module divides the treatment laser into multiple branch lasers, wherein each branch laser is arranged in rows and columns;

[0008] The optical modulation module independently regulates the power of each branch laser.

[0009] The optical fiber coupling module couples each branch laser into each optical fiber branch in the optical fiber array and transmits it to the focusing microlens array; wherein each optical fiber branch corresponds to a focusing microlens;

[0010] The focusing microlens array spatially focuses the multi-channel treatment lasers onto the lesion locations of the diseased tissue for ablation treatment.

[0011] In one embodiment, the spatial multi-focus based laser ablation device further includes: a controller connecting the treatment laser module and the light modulation module;

[0012] The controller is configured to control the therapeutic laser module to emit therapeutic laser and control the light modulation module to adjust the power of each branch laser.

[0013] In one embodiment, the optical modulation module includes a spatial light modulator connected to the controller; wherein the split lasers are modulated independently corresponding to an independent unit entering the spatial light modulator;

[0014] The controller controls each independent unit of the spatial light modulator to adjust the power of each branch laser.

[0015] In one embodiment, the controller is also configured to: calculate the switch state and power control parameters of each branch laser in the optical modulation module according to the biological tissue information of the diseased tissue; control the therapeutic laser module to emit a therapeutic laser with set parameters; and control the switch and power of each branch laser of the optical modulation module according to the switch state and power control parameters to perform ablation treatment on the lesion location point of the diseased tissue.

[0016] In one embodiment, the controller is also configured to: generate a scan image based on the biological tissue information of the diseased tissue; select an ablation range on the scan image, determine the lesion location points within the ablation range and calculate the ablation parameters of each lesion location point based on the biological tissue information; and calculate the switching state and power control parameters of each branch laser in the optical modulation module based on the lesion location points and their ablation parameters.

[0017] The technical solution of the above-mentioned embodiment provides a laser ablation device based on spatial multi-focus, which divides the therapeutic laser into multiple lasers for independent switching and power regulation, couples each laser into the optical fiber array one by one, and then focuses on the focal points of the diseased tissue through the focusing microlens array for ablation treatment; it can be used for the ablation of various irregular diseased tissues, the ablation range is controllable, the ablation is thorough, and damage to surrounding healthy tissues is avoided, especially when used in the ablation treatment of diseased tissues in the body, and the ablation range and accuracy can be controlled within a limited operating space.

[0018] A laser ablation diagnosis and treatment integrated device based on spatial multi-focus, comprising: the laser ablation device based on spatial multi-focus, and a diagnostic laser module connected before the optical fiber coupling module;

[0019] The diagnostic laser module is used to emit diagnostic laser, and the diagnostic laser enters the optical fiber coupling module;

[0020] The optical fiber coupling module is also used to couple the diagnostic laser into the optical fiber branch of the optical fiber array and transmit it to the focusing microlens array;

[0021] The focusing microlens array is also used to focus the diagnostic laser onto the biological tissue in space, generating a laser signal with tissue characteristic information; wherein the laser signal is used to diagnose the diseased tissue to obtain corresponding biological tissue information.

[0022] In one embodiment, the spatial multi-focus laser ablation diagnosis and treatment integrated device further includes: a light deflection module, a collimation module, and a combining module connected in sequence through an optical path;

[0023] The optical deflection module is connected to the diagnostic laser module, the combining module is arranged before the optical fiber coupling module, and the collimation module is arranged between the optical deflection module and the combining module;

[0024] The optical deflection module is connected to the diagnostic laser and deflects the diagnostic laser to a set angle so as to enter the collimation module;

[0025] The collimation module collimates the diagnostic laser and outputs it to the combining module;

[0026] The combining module inputs the branched laser of the treatment laser or the diagnostic laser into the optical fiber coupling module;

[0027] The optical fiber coupling module couples the branch laser or the diagnostic laser into the optical fiber branch of the optical fiber array.

[0028] In one embodiment, the controller is further connected to the diagnostic laser module and the light deflection module respectively;

[0029] The controller is further configured to control the diagnostic laser module to emit diagnostic laser with set parameters, and control the light deflection module to deflect the diagnostic laser at an angle.

[0030] In one embodiment, the focusing microlens array is also used to collect the laser signal and return it to the diagnostic laser module through the optical fiber array, the optical fiber coupling module, the combining module, the collimation module, and the light deflection module in sequence;

[0031] The diagnostic laser module is also used to separate the laser signal from the optical path, and analyze the laser signal to obtain signal characteristic parameters and send them to the controller;

[0032] The controller is also configured to calculate biological tissue information of the diseased tissue according to the signal characteristic parameters.

[0033] In one embodiment, the controller is further configured to:

[0034] During the diagnosis process, the diagnostic laser module is controlled to emit diagnostic laser, the optical deflection module is controlled to deflect the diagnostic laser by a specific angle, and the diagnostic laser is sequentially introduced into each optical fiber branch of the optical fiber array until all optical fiber branches are collected to obtain biological tissue information of the diseased tissue;

[0035] During the ablation process, the lesion location point is calculated according to the biological tissue information of the diseased tissue, and the branch lasers and their power control parameters that need to be turned on by the optical modulation module are calculated according to the lesion location point; the treatment laser module is controlled to emit treatment lasers with set parameters to perform ablation treatment on the lesion location point of the diseased tissue, and the optical modulation module is controlled to control the switching and power adjustment of each branch laser.

[0036] The technical solution of the above-mentioned embodiment further provides an integrated laser ablation diagnosis and treatment device based on spatial multi-focus, which has a compact structure and is easy to operate. It can perform biological tissue information diagnosis and ablation treatment on the diseased tissue successively, completing the two links of diagnosis and treatment in one process, reducing the treatment pain and harm caused to the patient, and is particularly conducive to real-time online diagnosis of in vivo tissues in a limited space.

[0037] Additional aspects and advantages of the present application will be partially given in the following description, which will become apparent from the following description, or will be understood through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0039] Figure 1 is a schematic structural diagram of a laser ablation device based on spatial multi-focus according to an embodiment;

[0040] Figure 2 is a schematic diagram of an example split laser interface;

[0041] Figure 3 is a schematic structural diagram of a laser ablation device based on spatial multi-focus according to another embodiment;

[0042] Figure 4 is a schematic diagram of an example spatial light modulator;

[0043] Figure 5 is a schematic diagram of a scanned image of an example of a diseased tissue;

[0044] Figure 6 It is a schematic diagram of the structure of a laser ablation diagnosis and treatment integrated device based on spatial multi-focus according to an embodiment;

[0045] Figure 7is a schematic structural diagram of a laser ablation diagnosis and treatment integrated device based on spatial multi-focus in another embodiment;

[0046] Figure 8 It is a schematic diagram of the coding of the deflection angle and the light-emitting point position. DETAILED DESCRIPTION

[0047] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and cannot be interpreted as limiting the present application.

[0048] Those skilled in the art will appreciate that, unless otherwise stated, the singular forms "a", "an", "said" and "the" used herein may also include plural forms. It should be further understood that the term "comprising" used in the specification of the present application refers to the presence of the features, integers, steps, operations, but does not exclude the presence or addition of one or more other features, integers, steps, operations.

[0049] It will be understood by those skilled in the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as those generally understood by those skilled in the art to which this application belongs. It should also be understood that terms such as those defined in general dictionaries should be understood to have meanings consistent with those in the context of the prior art, and will not be interpreted with idealized or overly formal meanings unless specifically defined as here.

[0050] The embodiment of the present application provides a laser ablation device based on spatial multi-focus, which can accurately ablate various irregular diseased tissues and improve the therapeutic effect of laser ablation.

[0051] refer to Figure 1 As shown, Figure 1 It is a schematic diagram of the structure of a laser ablation device based on spatial multi-focus of an embodiment, comprising: a treatment laser module 01, a spectroscopic module 02, a light modulation module 03, a fiber coupling module 04, a fiber array 05, and a focusing microlens array 06 which are sequentially connected through an optical path.

[0052] During ablation treatment, the treatment laser module 01 emits a treatment laser, the splitter module 02 divides the treatment laser into multiple branch lasers, each branch laser is arranged in rows and columns, the light modulation module 03 performs independent power regulation on each branch laser, the fiber coupling module 04 couples each branch laser into each fiber branch of the fiber array 05, and transmits them to the focusing microlens array 06 through each fiber branch. Each fiber branch corresponds to a focusing microlens. The focusing microlens array 06 spatially focuses the multiple treatment lasers to the lesion location point of the diseased tissue 10 for ablation treatment.

[0053] Exemplarily, the treatment laser module 01 can emit a treatment laser with set parameters, which can be a pulsed laser. The light splitting module 02 divides the treatment laser into multiple branch lasers with the same power, for example, the treatment laser is split into branch lasers with an n×n layout. The light splitting module 02 can use a fiber beam splitter or a spatial diffraction beam splitter to split the light. In order to distinguish the branch lasers, each branch laser is encoded in advance, so that the corresponding fiber branch and light output point position of the fiber array 05 can be known. The optical modulation module 03 performs independent power regulation on each branch laser. The optical modulation module 0 3. An optical modulator can be used to regulate the branch laser; the optical fiber coupling module 04 couples each branch laser into the optical fiber branch of the optical fiber array 05 respectively, and the optical fiber coupling module 04 can use a microlens array or a common lens group; the optical fiber array 05 can set the length according to the transmission distance, and each branch laser is transmitted to the focusing microlens array 06 through the optical fiber branch, and each optical fiber branch corresponds to a focusing microlens in the focusing microlens array 06. The focusing microlens array 06 is placed in front of the diseased tissue 10 to spatially focus each branch laser on the diseased tissue 10 to perform multi-focus ablation treatment.

[0054] like Figure 2 As shown, Figure 2 is a schematic diagram of an example split laser interface; Figure 2 The left figure in the middle shows the distribution shape of the irregular diseased tissue 10, and the right figure shows the switch list of each branch laser controlled by the light modulation module 03, where each square represents a branch of a laser, where " ○” means turning on the light, that is, the light path is connected, and “×” means turning off the light, that is, the light path is disconnected; it can be seen from 2 that when facing irregular diseased tissue, in order to avoid damage to the surrounding healthy tissue, the lesion position distribution shape of the diseased tissue 10 can be used, and then according to its shape and the layout of the light output points of the branch lasers, it can be determined which branch lasers need to be turned on and which need to be turned off, and then the switch control is performed through the optical modulation module 03; at the same time, during the ablation treatment process, the power of each branch laser is controlled according to the biological tissue information at each lesion position point of the diseased tissue 10, so that high-precision ablation treatment can be performed to achieve better ablation treatment effect.

[0055] In one embodiment, reference Figure 3 As shown, Figure 3 It is a schematic diagram of the structure of a laser ablation device based on spatial multi-focus of another embodiment; the laser ablation device based on spatial multi-focus of this embodiment also includes a controller 07 connecting the treatment laser module 01 and the light modulation module 03; at the same time, the controller 07 is configured to control the treatment laser module 01 to emit the treatment laser and control the light modulation module 03 to perform power regulation on each branch laser, and the ablation treatment can be precisely controlled by the controller 07.

[0056] In one embodiment, Figure 3 and Figure 4 As shown, Figure 4 This is a schematic diagram of an example spatial light modulator. The light modulation module 03 may include a spatial light modulator (SLM) connected to a controller 07, wherein the branch lasers correspond to an independent unit entering the spatial light modulator for independent modulation, and the controller 07 controls each independent unit of the spatial light modulator to adjust the power of each branch laser. The independent unit of the spatial light modulator may be controlled by an electrical signal to change the optical properties, such as reflectivity, transmittance and refractive index, so as to modulate each branch laser. The spatial light modulator may facilitate the switching optical parameter control of each branch laser, and the purpose of accurately controlling the power of the branch laser may be achieved by changing the optical parameters.

[0057] In this embodiment, the light modulation module 03 may use a spatial light modulator, a fiber acousto-optic modulator or a two-dimensional liquid crystal spatial light modulator, etc. Preferably, a two-dimensional liquid crystal spatial light modulator is used, and the branched lasers enter each liquid crystal pixel of the two-dimensional liquid crystal spatial light modulator in the light modulation module 03 for phase modulation and spectral intensity control; Figure 4The pixel array consists of 5×5 liquid crystals, and each pixel corresponds to a branch laser. The spectral phase is controlled by controlling the refractive index of each pixel of the spatial light modulator. By controlling each pixel of the spatial light modulator to use different frequencies and intensities, the liquid crystal shape of the 2D-SLM pixel can be controlled to control the refraction direction of the light, thereby realizing power control of the branch laser.

[0058] As in the above-mentioned embodiment, the laser ablation treatment technology based on spatial multi-focus can be used for ablation treatment of various irregular diseased tissues. The ablation range is controllable and damage to surrounding healthy tissues can be avoided. Especially when applied to ablation treatment of diseased tissues in the body, the ablation range and accuracy can be controlled within a limited operating space.

[0059] In one embodiment, the controller 07 is configured to control the treatment laser module 01 to emit treatment laser, and control the light modulation module 03 to adjust the power of each branch laser; when controlling the light modulation module 03 to adjust the power of each branch laser, it may include the following:

[0060] (1) Calculating the switch status and power control parameters of each branch laser in the optical modulation module 03 according to the biological tissue information of the diseased tissue 10 .

[0061] In one embodiment, the controller 07 may include the following when calculating the switch status and power control parameters of each branch laser:

[0062] a. Generate a scan image based on the biological tissue information of the diseased tissue 10.

[0063] Specifically, Figure 5 As shown, Figure 5 0 is a schematic diagram of a scanned image of an exemplary diseased tissue. The controller 07 can generate a scanned image according to biological tissue information of the diseased tissue 10 .

[0064] b. Selecting an ablation range on the scanned image, determining lesion location points within the ablation range, and calculating ablation parameters of each lesion location point according to the biological tissue information.

[0065] Specifically, the ablation range can be selected on the scanned image, and the AI ​​recognition model can be trained in advance using scanned images of various diseased tissues. The AI ​​recognition model can then be used to automatically locate the lesion location points in the scanned image, and the ablation parameters of each lesion location point can be calculated based on the biological tissue information.

[0066] In the above embodiment, by scanning the image and selecting the ablation range, visual selection and control of the ablation treatment area can be achieved, which is convenient to operate. At the same time, using AI to locate the lesion point can reduce the complexity of finding the lesion location, improve the operational efficiency of ablation treatment, and facilitate fast and accurate locating of the lesion location.

[0067] c. Calculate the switch state and power control parameters of each branch laser in the optical modulation module 03 according to the lesion location point and its ablation parameters.

[0068] Specifically, based on the lesion location point and the set ablation parameters, it is possible to calculate which branch lasers the light modulation module 03 needs to open, as well as the power parameters of each branch laser that is opened.

[0069] (2) Controlling the therapeutic laser module 01 to emit therapeutic laser with set parameters.

[0070] (3) Controlling the switch and power of each branch laser of the optical modulation module 03 according to the switch state and power control parameters, and performing ablation treatment on the lesion location of the diseased tissue 10 .

[0071] Specifically, the light modulation module 03 is controlled according to the ablation control parameters, including the switch state of each branch laser, the power value of the ablation treatment, the ablation treatment time, etc., to perform ablation treatment on each lesion location point of the diseased tissue 10 .

[0072] As in the scheme of the above-mentioned embodiment, by independently and precisely regulating the therapeutic laser of each optical fiber branch, corresponding to the shape of the lesion location point of the diseased tissue, high-precision control of the ablation range and time of each lesion location point is achieved, matching the ablation intensity of different lesion locations, realizing refined ablation, avoiding damage to surrounding healthy tissues, and achieving the purpose of precise ablation treatment.

[0073] An embodiment of a laser ablation diagnosis and treatment integrated device based on spatial multi-focus is described below.

[0074] The spatial multi-focus laser ablation diagnosis and treatment integrated device of the present application is intended to perform diagnostic screening and precise ablation treatment of diseased tissues; Figure 6 As shown, Figure 6 It is a schematic diagram of the structure of an integrated laser ablation diagnosis and treatment device based on spatial multi-focus according to an embodiment, comprising: a therapeutic laser module 01, a spectroscopic module 02, an optical modulation module 03, an optical fiber coupling module 04, an optical fiber array 05, a focusing microlens array 06 and a diagnostic laser module 11 connected in front of the optical fiber coupling module 04 in sequence.

[0075] Among them, the diagnostic laser module 11 has a built-in laser light source for emitting a diagnostic laser. The diagnostic laser can be a pulsed laser. The diagnostic laser enters the optical fiber coupling module 04. The optical fiber coupling module 04 couples the diagnostic laser into the optical fiber branch of the optical fiber array 05 and transmits it to the focusing microlens array 06. The focusing microlens array 06 focuses the diagnostic laser on the biological tissue 10 in space, generating a laser signal with tissue characteristic information, so that the corresponding biological tissue information of the diseased tissue 10 can be obtained based on the laser signal.

[0076] As shown in the above-mentioned embodiment, a laser ablation diagnosis and treatment integrated device with a compact structure and easy operation is provided, which can successively perform biological tissue information diagnosis and ablation treatment on the diseased tissue, completing the two links of diagnosis and treatment in one process, reducing the treatment pain and harm caused to the patient, and is particularly conducive to real-time online diagnosis of body tissues in a limited space.

[0077] In one embodiment, Figure 7 As shown, Figure 7 It is a structural schematic diagram of an integrated laser ablation diagnosis and treatment device based on spatial multi-focus of another embodiment. The integrated laser ablation diagnosis and treatment device based on spatial multi-focus of the present application also includes: an optical deflection module 12, a collimation module 13 and a combining module 14 which are sequentially connected through an optical path; wherein, the optical deflection module 12 is connected to the diagnostic laser module 11, the combining module 14 is arranged before the optical fiber coupling module 04, and the collimation module 13 is arranged between the optical deflection module 12 and the combining module 14; illustratively, the optical deflection module 12 can adopt an acousto-optic deflector or a galvanometer, and the collimation module 13 can adopt a collimating lens to realize the collimation function.

[0078] During diagnosis, the diagnostic laser module 11 emits a diagnostic laser, the optical deflection module 12 receives the diagnostic laser, deflects the diagnostic laser at a set angle to enter the collimation module 13, the collimation module 13 collimates the diagnostic laser and outputs it to the combining module 14, the combining module 14 inputs the branch laser of the therapeutic laser or the diagnostic laser into the optical fiber coupling module 04, the optical fiber coupling module 04 couples the branch laser or the diagnostic laser to the optical fiber branch of the optical fiber array 05, and finally transmits it to the focusing microlens array 06 through the optical fiber branch to be spatially focused on the biological tissue 10.

[0079] As in the scheme of the above-mentioned embodiment, a diagnostic laser is used to focus on the biological tissue 10 through the focusing microlens of the focusing microlens array 06 for diagnosis, so that multiple positions of the biological tissue 10 can be diagnosed, thereby obtaining more accurate biological tissue information of the biological tissue 10, thereby guiding more precise ablation treatment.

[0080] In one embodiment, for the combining module 14, a polarization beam combiner can be used to realize the beam combining function to realize the input of the branch laser and the diagnostic laser, and a movable or flip mirror frame platform can be used to realize the switching of the two input optical paths. Compared with the polarization beam combining method, the switching of the optical path can improve the optical path efficiency and will not affect the optical power of the returning laser signal, thereby ensuring the power of the laser signal and the integrity of the information.

[0081] In one embodiment, Figure 7 As shown, in the integrated laser ablation diagnosis and treatment device based on spatial multi-focus of the present application, the controller 07 is also connected to the diagnostic laser module 11 and the light deflection module 12 respectively; wherein, the controller 07 is also configured to control the diagnostic laser module 11 to emit a diagnostic laser with set parameters, and to control the light deflection module 12 to deflect the diagnostic laser so that the diagnostic laser enters the collimation module 13 and then enters one of the branch lasers for transmission.

[0082] In one embodiment, Figure 6 and Figure 7 As shown, the focusing microlens array 06 is also used to collect laser signals, and return them to the diagnostic laser module 11 through the optical fiber array 05, the optical fiber coupling module 04, the combining module 14, the collimation module 13, and the optical deflection module 12 in sequence; wherein, the diagnostic laser module 11 is also used to separate the laser signal from the optical path, and analyze the laser signal to obtain signal characteristic parameters and send them to the controller 07, and the controller 07 is also configured to calculate the biological tissue information of the diseased tissue 10 according to the signal characteristic parameters; illustratively, the diagnostic laser module 11 can separate the laser signal by a dichroic mirror arranged on the optical path, and the controller 07 can calculate the biological tissue information of the diseased tissue 10 using the signal characteristic parameters returned by each optical fiber branch.

[0083] As shown in the above-mentioned embodiment, a laser ablation diagnosis and treatment integrated device based on spatial multi-focus is provided, which has a compact structure and is easy to operate. It can perform biological tissue information diagnosis and ablation treatment on diseased tissues, completing both diagnosis and treatment in one process, reducing the pain and harm of treatment to patients, and is particularly conducive to real-time online diagnosis of in vivo tissues in limited space.

[0084] In one embodiment, in the spatial multi-focus laser ablation diagnosis and treatment integrated device of the present application, the controller (07) can be configured to perform the following functions:

[0085] During the diagnosis process, the diagnostic laser module 11 is controlled to emit a diagnostic laser, and the light deflection module 12 is controlled to deflect the diagnostic laser at a specific angle, and the diagnostic laser is introduced into each optical fiber branch of the optical fiber array 05 in turn until all optical fiber branches are collected to obtain the biological tissue information of the diseased tissue 10.

[0086] Exemplarily, the diagnostic laser module 11 emits a diagnostic laser, and the light deflection module 12 is controlled to deflect the diagnostic laser at a set angle and couple it into one of the branch optical fibers, and then the laser signal is collected; after completing this collection, the light deflection module 12 is controlled to deflect the diagnostic laser at another angle, so that the diagnostic laser is coupled into another optical fiber branch, and the laser signal is collected again, and so on, and the operation is cyclic until all optical fiber branches are collected.

[0087] refer to Figure 8 As shown, Figure 8 This is an example of the coding diagram of the deflection angle and the light output point position; the light spot position of each branch optical fiber is encoded, and each light spot position corresponds to a deflection angle θ, and the deflection angle θ is a spatial angle. Thus, n optical fibers can form a deflection angle θ 1 ~θ n , for example, the deflection angle θ when n=5×5 in the figure 1 ~θ 25 , which can correspond to branch optical fibers coded 1 to 25 respectively; as shown in the figure, the branch optical fibers start from code 1 to code 25, and the controller 07 rotates according to the deflection angle θ 1 ~θ 25 The diagnostic laser is deflected in sequence to couple it into each optical fiber branch of the optical fiber array 05. The focusing microlens array 06 focuses the diagnostic laser onto the diseased tissue 10, generating a laser signal with tissue characteristic information that returns along the original path to the diagnostic laser module 11 for parameter characteristic analysis. The signal characteristic parameters are sent to the controller 07 to obtain the corresponding biological tissue information at the focus of the branch optical fiber. After all position points are collected, the biological tissue information collected by each branch optical fiber can be used to generate a scanning image of the diseased tissue 10, which can be used for rapid and accurate pathological diagnosis of the diseased tissue 10, thereby improving diagnostic efficiency, reducing harm to patients and alleviating pain.

[0088] During the ablation process, the lesion location point is calculated according to the biological tissue information of the diseased tissue 10, and the branch lasers that need to be turned on by the light modulation module 03 and their power control parameters are calculated according to the lesion location point; the treatment laser module 01 is controlled to emit the treatment laser with set parameters to perform ablation treatment on the lesion location point of the diseased tissue 10, and the light modulation module 03 is controlled to perform switching control and power regulation of each branch laser; for the ablation process, you can refer to the relevant contents of the previous embodiments, which will not be repeated here.

[0089] To sum up the technical solutions of the above embodiments, the integrated laser ablation diagnosis and treatment device based on spatial multi-focus successively performs biological tissue information diagnosis and ablation treatment on the diseased tissue, completing the two links of diagnosis and treatment in one process. It can be used for the ablation of various irregular diseased tissues, the ablation range is controllable, the ablation is thorough, and damage to surrounding healthy tissues is avoided, reducing the pain and harm of treatment to patients. It is particularly beneficial for real-time online diagnosis of tissues in the body in a limited space, and ablation treatment of diseased tissues in the body at the same time, and the ablation range and accuracy can be controlled within a limited operating space.

[0090] The above description is only a partial implementation method of the present application. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present application. These improvements and modifications should also be regarded as the scope of protection of the present application.

Claims

1. A laser ablation device based on spatial multi-focus, characterized in that: include: A therapeutic laser module (01), a light splitting module (02), a light modulation module (03), a fiber coupling module (04), a fiber array (05), and a focusing microlens array (06) connected in sequence through an optical path; The therapeutic laser module (01) is used to emit therapeutic laser; The light splitting module (02) splits the treatment laser into multiple branch lasers, wherein each branch laser is arranged in rows and columns; The optical modulation module (03) performs independent power regulation on each branch laser. The optical fiber coupling module (04) couples each branch laser into each optical fiber branch in the optical fiber array (05) and transmits the laser to the focusing microlens array (06); wherein each optical fiber branch corresponds to a focusing microlens; The focusing microlens array (06) spatially focuses the multi-channel treatment lasers onto the lesion locations of the diseased tissue (10) to perform ablation treatment.

2. The spatial multi-focus laser ablation device according to claim 1, characterized in that: Also includes: A controller (07) connected to the therapeutic laser module (01) and the light modulation module (03); The controller (07) is configured to control the therapeutic laser module (01) to emit therapeutic laser and control the light modulation module (03) to regulate the power of each branch laser.

3. The laser ablation device based on spatial multi-focus according to claim 2, characterized in that: The optical modulation module (03) comprises a spatial light modulator connected to the controller (07); wherein the branched laser beams are modulated independently corresponding to an independent unit entering the spatial light modulator; The controller (07) controls each independent unit of the spatial light modulator to adjust the power of each branch laser.

4. The laser ablation device based on spatial multi-focus according to claim 3, characterized in that: The controller (07) is also configured to: calculate the switch state and power control parameters of each branch laser in the light modulation module (03) according to the biological tissue information of the diseased tissue (10); control the treatment laser module (01) to emit treatment laser with set parameters; and control the switch and power of each branch laser of the light modulation module (03) according to the switch state and power control parameters to perform ablation treatment on the lesion location point of the diseased tissue (10).

5. The laser ablation device based on spatial multi-focus according to claim 4, characterized in that: The controller (07) is also configured to: generate a scan image based on the biological tissue information of the diseased tissue (10); select an ablation range on the scan image, determine the lesion location point within the ablation range and calculate the ablation parameters of each lesion location point based on the biological tissue information; and calculate the switching state and power control parameters of each branch laser in the optical modulation module (03) based on the lesion location point and its ablation parameters.

6. A laser ablation diagnosis and treatment integrated device based on spatial multi-focus, characterized in that: include: The laser ablation device based on spatial multi-focus according to any one of claims 1 to 5, and a diagnostic laser module (11) connected before the optical fiber coupling module (04); The diagnostic laser module (11) is used to emit diagnostic laser light, and the diagnostic laser light enters the optical fiber coupling module (04); The optical fiber coupling module (04) is also used to couple the diagnostic laser into the optical fiber branch of the optical fiber array (05) and transmit it to the focusing microlens array (06); The focusing microlens array (06) is also used to focus the diagnostic laser onto the biological tissue (10) in space, generating a laser signal with tissue characteristic information; wherein the laser signal is used to diagnose the diseased tissue (10) to obtain corresponding biological tissue information.

7. The laser ablation diagnosis and treatment integrated device based on spatial multi-focus according to claim 6, characterized in that: Also includes: A light deflection module (12), a collimation module (13) and a combining module (14) connected in sequence through an optical path; The light deflection module (12) is connected to the diagnostic laser module (11), the combining module (14) is arranged before the optical fiber coupling module (04), and the collimation module (13) is arranged between the light deflection module (12) and the combining module (14); The optical deflection module (12) is connected to the diagnostic laser and deflects the diagnostic laser at a set angle so as to enter the collimation module (13); The collimation module (13) collimates the diagnostic laser and outputs it to the combining module (14); The combining module (14) inputs the branched laser of the treatment laser or the diagnostic laser into the optical fiber coupling module (04); The optical fiber coupling module (04) couples the branch laser or diagnostic laser into the optical fiber branch of the optical fiber array (05).

8. The spatial multi-focus laser ablation diagnosis and treatment integrated device according to claim 7, characterized in that: The controller (07) is also connected to the diagnostic laser module (11) and the light deflection module (12) respectively; The controller (07) is also configured to control the diagnostic laser module (11) to emit diagnostic laser light with set parameters, and to control the light deflection module (12) to deflect the diagnostic laser light at an angle.

9. The spatial multi-focus laser ablation diagnosis and treatment integrated device according to claim 8, characterized in that: The focusing microlens array (06) is also used to collect the laser signal and return it to the diagnostic laser module (11) through the optical fiber array (05), the optical fiber coupling module (04), the combining module (14), the collimation module (13), and the light deflection module (12) in sequence; The diagnostic laser module (11) is also used to separate the laser signal from the optical path, analyze the laser signal to obtain signal characteristic parameters and send them to the controller (07); The controller (07) is also configured to calculate biological tissue information of the diseased tissue (10) based on the signal characteristic parameters.

10. The spatial multi-focus laser ablation diagnosis and treatment integrated device according to claim 9, characterized in that: The controller (07) is also configured to: During the diagnosis process, the diagnostic laser module (11) is controlled to emit diagnostic laser light, and the optical deflection module (12) is controlled to deflect the diagnostic laser light at a specific angle, and the diagnostic laser light is sequentially introduced into each optical fiber branch of the optical fiber array (05), until all optical fiber branches are collected to obtain biological tissue information of the diseased tissue (10); During the ablation process, the lesion location point is calculated based on the biological tissue information of the diseased tissue (10), and the branch lasers and their power control parameters that need to be turned on by the optical modulation module (03) are calculated based on the lesion location point; the treatment laser module (01) is controlled to emit treatment lasers with set parameters to perform ablation treatment on the lesion location point of the diseased tissue (10), and the optical modulation module (03) is controlled to perform switch control and power regulation on each branch laser.

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