Formula, preparation method and application of bitter honeysuckle sweet skin decoction for treating hand-foot syndrome

Abstract

The invention belongs to the technical field of formulas of bitter-silver-sweet skin decoction, and discloses a formula, a preparation method and application of bitter-silver-sweet skin decoction for treating hand-foot syndrome. The formula is fixed, components and proportions of the medicine formula do not need to be adjusted according to specific conditions of patients, and the formula is suitable for better popularization and application. The traditional Chinese medicine composition has a multi-target effect: the traditional Chinese medicine possibly contains various components, and the components possibly play roles through various mechanisms, such as inflammation resistance, oxidation resistance, blood circulation promotion and the like, so that the symptoms of the hand-foot syndrome are improved. The traditional Chinese medicine treatment pays attention to overall body conditioning, can not only aim at the symptoms of the hand-foot syndrome, but also adjust the physique, viscera functions and the like of the patient, and improves the compliance of the patient in anti-tumor treatment, so that the treatment effect is improved, and relapse is prevented. The side effect is less.

Description

Technical Field

[0001] The invention belongs to the technical field of Kuyin Ganfu Decoction prescriptions, and in particular relates to a Kuyin Ganfu Decoction prescription for treating hand-foot syndrome, a preparation method and application thereof. Background Art

[0002] Hand-Foot Syndromes (HFS) are a common skin toxicity that often occurs during cancer treatment, especially after chemotherapy and targeted therapy. HFS is characterized by redness, swelling, pain, blistering, scaling, and cracking of the palms and soles, which seriously affects the patient's quality of life and treatment compliance. In cancer treatment, clinicians usually choose the appropriate treatment plan based on the patient's specific situation. However, for some patients, HFS may cause severe discomfort and functional impairment, and even require suspension of anti-tumor treatment. Therefore, finding an effective treatment for HFS is of great clinical significance.

[0003] At present, the treatment methods of HFS mainly include local care, drug treatment and preventive measures. Local care includes keeping the skin clean and dry, using moisturizers and protective agents, and avoiding friction and irritation. Drug treatment includes the use of analgesics, anti-inflammatory drugs, keratinogens and keratolytics. Preventive measures include adjusting the treatment dose and time, using skin protectants, and supplementing vitamins. However, the effects of these treatments are not ideal and have certain limitations. Therefore, the development of new HFS treatment methods is one of the current clinical research hotspots.

[0004] In recent years, with the in-depth study of the pathogenesis of HFS, some new treatment methods have gradually emerged. Some studies have shown that the use of growth factor inhibitors, vascular endothelial growth factor inhibitors, cytokine antagonists and other drugs can alleviate the symptoms of HFS. In addition, some physical therapy methods, such as low-intensity laser therapy and ultrasound therapy, have also been used to treat HFS.

[0005] In general, the background of inventing the treatment method of hand-foot syndrome is to further improve the treatment effect of HFS, relieve the pain of patients and improve their quality of life.

[0006] Hand-foot syndrome is a common side effect of chemotherapy, which may cause symptoms such as redness, swelling, pain, blistering, scaling and cracking of the skin on the palms and soles of the feet. The following are some existing treatments for hand-foot syndrome and their advantages and disadvantages. 1. Local care: Keep the skin clean and dry, avoid friction and irritation, and use moisturizers and protectants. This method is simple and easy to use, but it has limited effect on severe hand-foot syndrome. 2. Drug treatment: Use drugs such as analgesics, anti-inflammatory drugs, keratinogens and keratolytics. Drug treatment can relieve symptoms, but there may be some side effects, and COX-2 inhibitors have potential cardiovascular risks. 3. Adjust the dose and time of treatment: Adjust the dose and time of chemotherapy drugs according to the patient's condition to reduce the risk of hand-foot syndrome. This method requires doctors to adjust according to the specific situation of the patient, which may affect the treatment effect of the tumor. 4. Use skin protectants: Using skin protectants containing urea, salicylic acid, vaseline and other ingredients can reduce dryness and cracking of the skin; this method requires patients to use it by themselves, and they need to pay attention to the method and frequency of use. Some people may be allergic to the ingredients in the skin protectants, causing allergic reactions such as skin redness, itching, and swelling; if the skin protectants are used improperly, they may irritate the skin, causing discomfort symptoms such as skin pain and burning sensation. 5. Vitamin supplementation and topical use of glucocorticoids: Supplementation of vitamins B6, E, B12 and the use of glucocorticoids can help relieve the symptoms of hand-foot syndrome. This method requires long-term use, and the effect may vary from person to person. High doses of vitamin E may increase the risk of bleeding, and excessive intake of vitamin B6 may cause neurotoxicity. Long-term or high-dose use of glucocorticoids may cause systemic side effects such as increased blood sugar, increased blood pressure, and osteoporosis. 6. Traditional Chinese medicine formula: The existing Chinese medicine formula needs to be adjusted according to the patient's specific situation, such as constitution, symptoms, course of disease, etc., which requires a high level of diagnosis and treatment from the doctor to achieve a treatment effect that is more in line with individual needs. This treatment model may vary in efficacy from person to person due to factors such as the quality of medicinal materials, preparation methods, formula ratios, and individual differences, and is not suitable for large-scale clinical promotion.

[0007] Through the above analysis, the problems and defects of the prior art are as follows:

[0008] The existing treatments for HFS are not ideal and have certain limitations. Summary of the invention

[0009] In view of the problems existing in the prior art, the present invention provides a Kuyin Ganfu Decoction formula, a preparation method and application for treating hand-foot syndrome.

[0010] The present invention is achieved in that a Kuyin Ganfu decoction formula for treating hand-foot syndrome comprises the following ingredients:

[0011] Sophora flavescens 30-35g, Phragmites australis 30-35g, Honeysuckle 30-35g, Forsythia suspensa 15-20g, Scutellaria baicalensis 15-20g, Licorice 15-20g, Cortex Moutan 15-20g, Kochia scoparia 10g, Cnidium monnieri 10g, and bear bile powder 0.3g.

[0012] Another object of the present invention is to provide a method for preparing a Kuyin Ganfu Decoction prescription for treating hand-foot syndrome, comprising:

[0013] Step 1, mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder, and add 2000ml of water;

[0014] Step 2, simmer for 30 minutes after boiling, then pour into the footbath;

[0015] Step 3, cool down to between 35℃ and 40℃, soak the affected hands and feet for 20 minutes, twice a day.

[0016] Another object of the present invention is to provide a Kuyin Ganfu Decoction prescription preparation system for treating hand-foot syndrome, comprising:

[0017] A mixing module is used to mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder and add 2000ml of water;

[0018] The decoction module is used to fry the food and then cook it for 30 minutes after boiling, and then pour it into the footbath;

[0019] The cooling module is used to cool the body to between 35°C and 40°C and soak the affected hands and feet for 20 minutes, twice a day.

[0020] Another object of the present invention is to provide a computer device, comprising a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the method for preparing the Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0021] Another object of the present invention is to provide a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to execute the steps of the method for preparing the Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0022] Another object of the present invention is to provide an information data processing terminal, which is used to implement the Kuyin Ganfu Decoction prescription preparation system for treating hand-foot syndrome.

[0023] In combination with the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0024] First, soaking hands and feet in Kuyin Ganfu Decoction for the treatment of hand-foot syndrome may have the following advantages: 1. Fixed formula: The formula does not need to adjust the ingredients and proportions of the drug formula according to the specific situation of the patient, which is suitable for better promotion and use. 2. Multi-target effect: Chinese medicine may contain a variety of ingredients, which may work through a variety of mechanisms, such as anti-inflammatory, antioxidant, and promoting blood circulation, thereby improving the symptoms of hand-foot syndrome. 3. Overall conditioning: Chinese medicine treatment focuses on conditioning the body as a whole, which may not only target the symptoms of hand-foot syndrome, but also regulate the patient's constitution, visceral function, etc., increase the patient's compliance with anti-tumor treatment, so as to improve the treatment effect and prevent recurrence. 4. Fewer side effects: Compared with some Western medicines, Chinese medicine has relatively fewer side effects when used externally for a long time. 5. High patient acceptance: Chinese medicine may be more acceptable to some patients because it has a long history and cultural background and is considered to be mild and natural. Therefore, soaking hands and feet in Kuyin Ganfu Decoction for the treatment of hand-foot syndrome has certain potential.

[0025] Second, as auxiliary evidence of the inventiveness of the claims of the present invention, it is also reflected in the following important aspects:

[0026] (1) The expected benefits and commercial value of the technical solution of the present invention after transformation are:

[0027] Hand-foot syndrome is a common disease that seriously affects the quality of life of patients. There is a large population of patients who need chemotherapy and targeted therapy. There is a high demand for effective treatment options for hand-foot syndrome. Treatment options that can provide better efficacy or address the limitations of existing treatments may attract the attention of pharmaceutical companies and investors to further improve treatment methods. Clinical data and images can prove the safety and effectiveness of treatment options and provide strong support for subsequent research and development and commercialization. The wider the range of indications for the treatment option, the larger the potential patient population and the higher the commercial value.

[0028] (2) The technical solution of the present invention fills the technical gap in the industry at home and abroad:

[0029] The present invention provides a new treatment method for hand-foot syndrome, which has significant advantages over existing treatment methods. Compared with existing Chinese medicine prescriptions, this technology may provide a new treatment target for the pathogenesis of hand-foot syndrome, the treatment course is short, and the implementation of the treatment plan is not limited by the doctor's level and the individual patient, which meets the needs of a wide range of hand-foot syndrome patients.

[0030] (3) The technical solution of the present invention solves the technical problems that people have been eager to solve but have never been able to solve successfully:

[0031] This solution solves the technical problem that Chinese medicine prescriptions must be made in person and the prescriptions must be individualized.

[0032] (4) The technical solution of the present invention overcomes technical prejudice:

[0033] The present invention overcomes the technical prejudice that the existing Chinese medicine prescriptions have poor efficacy and complicated operation. The present invention has better efficacy and simpler operation. It overcomes the limitations of the existing Chinese medicine prescriptions and shows good effects in clinical practice.

[0034] Third, the technical solution of the present invention exhibits multiple key advantages in solving the technical problems of the prior art and achieving significant technological progress.

[0035] 1. Solved technical problems of existing technologies

[0036] In the prior art, the treatment of hand-foot syndrome usually adopts local external application of traditional Chinese medicine or western medicine.

[0037] However, existing methods have the following problems:

[0038] Limited efficacy: Traditional Chinese medicine topical preparations have poor drug permeability and slow efficacy, making it difficult to effectively relieve the symptoms of hand-foot syndrome, such as redness, swelling, pain, and dry skin.

[0039] Many side effects: Some Western medicines used to treat hand-foot syndrome may cause side effects such as skin irritation and allergies, especially when used for a long time, which can easily lead to adverse reactions.

[0040] Individual differences have a significant impact: Existing treatment methods are often difficult to adapt to the individual differences of different patients, the effects are not stable enough, and there is significant volatility in efficacy.

[0041] 2. Significant progress in technical solutions

[0042] The present invention has achieved significant progress in solving these technical problems in the treatment of hand-foot syndrome by developing a combination of Kuyin Ganfu Decoction based on a traditional Chinese medicine prescription:

[0043] Combination of multiple therapeutic effects: The formula of the present invention combines a variety of Chinese medicinal ingredients that have the functions of clearing away heat and detoxifying, reducing swelling and relieving pain, moisturizing and relieving itching, such as Sophora flavescens, Honeysuckle, Scutellaria baicalensis, etc. These medicinal materials are scientifically matched to form a formula with comprehensive therapeutic effects, which can promote skin repair, improve local blood circulation, and accelerate the recovery process while relieving symptoms.

[0044] Improve drug permeability: By adding bear bile powder and other ingredients into the formula, the present invention effectively improves the permeability of the drug, making it easier for the active ingredients to penetrate into the deep layers of the skin, thereby significantly improving the therapeutic effect.

[0045] Reduced side effects: Since the invention uses natural Chinese medicine ingredients, it avoids the side effects of chemical drugs, especially the safety of long-term use is guaranteed. During use, the patient's skin irritation is greatly reduced, which is more suitable for sensitive skin or long-term treatment needs.

[0046] Wide applicability: The formula of the present invention is scientifically formulated to adapt to patients with different physiques and degrees of hand-foot syndrome, and provides a variety of usage methods through different application forms (such as decoctions, ointments, sprays, etc.) to meet the needs of different patients, further enhancing the flexibility and effectiveness of treatment.

[0047] 3. Significant technological progress

[0048] The present invention has shown significant technical progress in the following aspects:

[0049] Improved efficacy: By optimizing the drug ratio and adding excipients, the present invention improves the therapeutic effect while shortening the treatment cycle, and has a faster effect time compared to traditional Chinese medicine treatment.

[0050] Enhanced safety: The present invention adopts a natural drug formula, avoiding the toxic side effects that may be caused by chemical drugs. It is especially suitable for patients with long-term treatment needs, and its safety is significantly improved.

[0051] Convenience of use: Through innovative drug forms, such as sprays, ointments, etc., the present invention improves the convenience of use and patient compliance, especially in daily care and prevention and treatment of recurrence, providing a more effective and convenient solution.

[0052] The present invention successfully solves many technical problems existing in the existing treatment of hand-foot syndrome through the development of the traditional Chinese medicine formula Kuyin Ganfu Decoction, and achieves technical progress with significantly improved efficacy, reduced side effects and wide applicability. This innovative solution not only provides patients with more effective treatment options, but also provides solid technical support for the long-term prevention and treatment of hand-foot syndrome. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] Figure 1 The present invention provides a flow chart of a method for preparing a Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0054] Figure 2 The present invention provides a block diagram of the structure of a system for preparing a Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0055] Figure 3 This is a diagram before oral capecitabine treatment provided by an embodiment of the present invention.

[0056] Figure 4 This is a graph after 7 days of oral capecitabine treatment provided by an embodiment of the present invention.

[0057] Figure 5 This is a diagram before oral sorafenib treatment provided by an embodiment of the present invention.

[0058] Figure 6 This is a graph after 7 days of oral sorafenib treatment provided by an embodiment of the present invention.

[0059] Figure 7 This is the clinical application case 1 provided by the embodiment of the present invention.

[0060] Figure 8 This is clinical application case 2 provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0061] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0062] The following are 6 examples of Kuyin Ganfu Decoction prescriptions for treating hand-foot syndrome:

[0063] Example 1

[0064] Recipe Ingredients:

[0065] Sophora flavescens: 30g

[0066] Phragmites australis: 30g

[0067] Honeysuckle: 30g

[0068] Forsythia: 15g

[0069] Scutellaria baicalensis: 15g

[0070] Licorice: 15g

[0071] Cortex Moutan: 15g

[0072] Kochia scoparia: 10g

[0073] Cnidium monnieri: 10g

[0074] Bear bile powder: 0.3g

[0075] Directions:

[0076] Mix all ingredients according to the above dosage, add water and boil twice, boil for 1 hour each time, combine the decoction and take it twice. One dose per day for 7 consecutive days. This formula is mainly used for patients with mild hand-foot syndrome, and has the effects of clearing heat and detoxifying, moisturizing and relieving itching.

[0077] Example 2

[0078] Recipe Ingredients:

[0079] Sophora flavescens: 35g

[0080] Phragmites australis: 35g

[0081] Honeysuckle: 35g

[0082] Forsythia: 20g

[0083] Scutellaria baicalensis: 20g

[0084] Licorice: 20g

[0085] Cortex Moutan: 20g

[0086] Kochia scoparia: 10g

[0087] Cnidium monnieri: 10g

[0088] Bear bile powder: 0.3g

[0089] Directions:

[0090] Mix all ingredients, add water and boil twice, boil for 1.5 hours each time, and take it twice a day, morning and evening. One dose per day, take for 10 consecutive days. It is suitable for patients with moderate hand-foot syndrome, and effectively relieves symptoms such as skin redness, swelling, and burning pain.

[0091] Example 3

[0092] Recipe Ingredients:

[0093] Sophora flavescens: 32g

[0094] Phragmites australis: 32g

[0095] Honeysuckle: 32g

[0096] Forsythia: 18g

[0097] Scutellaria baicalensis: 18g

[0098] Licorice: 18g

[0099] Cortex Moutan: 18g

[0100] Kochia scoparia: 10g

[0101] Cnidium monnieri: 10g

[0102] Bear bile powder: 0.3g

[0103] Directions:

[0104] Mix all the ingredients, add water and boil for 1 hour, combine the decoction and use it for foot bath, soak your feet for 30 minutes every day. Soak your feet for 7 consecutive days. This method is suitable for foot symptoms caused by hand-foot syndrome, such as dry, cracked, and painful foot skin, and has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis.

[0105] Example 4

[0106] Recipe Ingredients:

[0107] Sophora flavescens: 30g

[0108] Phragmites australis: 30g

[0109] Honeysuckle: 30g

[0110] Forsythia: 20g

[0111] Scutellaria baicalensis: 20g

[0112] Licorice: 15g

[0113] Cortex Moutan: 15g

[0114] Kochia scoparia: 10g

[0115] Cnidium monnieri: 10g

[0116] Bear bile powder: 0.3g

[0117] Directions:

[0118] Mix all the ingredients and boil them twice for 1 hour each time. Combine the decoctions and use them as hand soaks. Soak your hands for 30 minutes daily for 10 days. This method is mainly used to relieve symptoms of hand-foot syndrome, such as cracked skin, redness, swelling, and pain in the hands.

[0119] Example 5

[0120] Recipe Ingredients:

[0121] Sophora flavescens: 33g

[0122] Phragmites australis: 33g

[0123] Honeysuckle: 33g

[0124] Forsythia: 19g

[0125] Scutellaria baicalensis: 19g

[0126] Licorice: 19g

[0127] Cortex Moutan: 19g

[0128] Kochia scoparia: 10g

[0129] Cnidium monnieri: 10g

[0130] Bear bile powder: 0.3g

[0131] Directions:

[0132] Mix all ingredients, add water and boil, concentrate the decoction, add vaseline to make ointment. Apply to the affected parts of hands and feet once in the morning and evening every day for 14 consecutive days. It is suitable for severely dry and painful skin caused by hand-foot syndrome, and effectively promotes skin healing.

[0133] Example 6

[0134] Recipe Ingredients:

[0135] Sophora flavescens: 34g

[0136] Phragmites australis: 34g

[0137] Honeysuckle: 34g

[0138] Forsythia: 20g

[0139] Scutellaria baicalensis: 20g

[0140] Licorice: 20g

[0141] Cortex Moutan: 20g

[0142] Kochia scoparia: 10g

[0143] Cnidium monnieri: 10g

[0144] Bear bile powder: 0.3g

[0145] Directions:

[0146] Mix all ingredients, add water and boil, take out the decoction, cool to a suitable temperature, and put the decoction into a spray bottle. Spray on the affected parts of the hands and feet every day, once in the morning and once in the evening, for 14 consecutive days. It is suitable for skin care of patients with hand-foot syndrome, and has the effects of clearing away heat, detoxifying, reducing swelling and relieving pain.

[0147] A Kuyin Ganfu Decoction formula for treating hand-foot syndrome provided in an embodiment of the present invention comprises the following ingredients:

[0148] Sophora flavescens 30-35g, Phragmites australis 30-35g, Honeysuckle 30-35g, Forsythia suspensa 15-20g, Scutellaria baicalensis 15-20g, Licorice 15-20g, Cortex Moutan 15-20g, Kochia scoparia 10g, Cnidium monnieri 10g, and bear bile powder 0.3g.

[0149] like Figure 1 As shown, a method for preparing a Kuyin Ganfu Decoction prescription for treating hand-foot syndrome provided by an embodiment of the present invention comprises:

[0150] S101, mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice root, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder, and add 2000ml of water;

[0151] S102, fry until boiling and then cook for 30 minutes, pour into the foot basin;

[0152] S103, cool down to between 35℃ and 40℃, soak the affected hands and feet for 20 minutes, twice a day.

[0153] like Figure 2 As shown, a Kuyin Ganfu Decoction prescription preparation system for treating hand-foot syndrome provided by an embodiment of the present invention comprises:

[0154] A mixing module is used to mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder and add 2000ml of water;

[0155] The decoction module is used to fry the food and then cook it for 30 minutes after boiling, and then pour it into the footbath;

[0156] The cooling module is used to cool the body to between 35°C and 40°C and soak the affected hands and feet for 20 minutes, twice a day.

[0157] Another object of the present invention is to provide a computer device, comprising a memory and a processor, wherein the memory stores a computer program, and when the computer program is executed by the processor, the processor executes the steps of the method for preparing the Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0158] Another object of the present invention is to provide a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to execute the steps of the method for preparing the Kuyin Ganfu Decoction formula for treating hand-foot syndrome.

[0159] Another object of the present invention is to provide an information data processing terminal, which is used to implement the Kuyin Ganfu Decoction prescription preparation system for treating hand-foot syndrome.

[0160] Hand-foot syndrome is a toxic skin reaction that often occurs on the palms and soles of the feet. In traditional Chinese medicine, it can be classified as "herpes", "rashes", "sores", "skin and nail disorders". Traditional Chinese medicine believes that its onset is related to exogenous toxic evils, improper diet, emotional injury, and imbalance between work and rest. Exogenous toxic evils, heat and toxins accumulate in the skin; improper diet damages the spleen and stomach, the spleen fails to function properly, dampness is generated internally, and over time it turns into heat, and dampness and heat accumulate in the skin; emotional injury, liver qi stagnation, over time it turns into fire, liver fire is blazing, or liver depression suppresses the spleen, the spleen fails to function properly, phlegm and dampness are generated internally, and fire, heat, and phlegm and dampness stagnate in the skin; imbalance between work and rest, excessive fatigue, damage to qi and blood, leading to a decrease in the body's immunity, can all cause this disease.

[0161] In terms of treatment, TCM adopts different treatment methods according to different syndrome types. For example, for heat-toxin accumulation syndrome, the treatment should be clearing away heat and detoxification, promoting blood circulation and relieving pain, and the prescription is Wuwei Xiaoduyin combined with Huoxue Sanyu Tang with modifications; for damp-heat accumulation syndrome, the treatment should be clearing away heat and dampness, detoxifying and unblocking collaterals, and the prescription is Bixie Shenshi Tang combined with Sanmiao Wan with modifications; for liver depression and spleen deficiency syndrome, the treatment should be soothing the liver and strengthening the spleen, promoting dampness and detoxification, and the prescription is Xiaoyao San combined with Shenling Baizhu San with modifications; for qi and blood deficiency syndrome, the treatment should be invigorating qi and nourishing blood, detoxifying and unblocking collaterals, and the prescription is Bazhen Tang combined with Simiao Yong'an Tang with modifications. In addition, TCM also often uses Chinese medicine external washing, Chinese medicine external application, acupuncture and other methods to treat hand-foot syndrome.

[0162] Therefore, I made a Kuyin Ganfu Decoction for bathing hands and feet. Sophora flavescens can clear away heat and dampness, kill insects and promote diuresis. Phragmites australis can clear away heat and promote the production of body fluids. Honeysuckle can clear away heat and detoxify, promote blood circulation and activate collaterals, and protect the skin and beautify the body. Forsythia suspensa can clear away heat and detoxify, disperse nodules and reduce swelling. Scutellaria baicalensis can clear away heat and dampness, purge fire and detoxify. Licorice can detoxify, invigorate qi and harmonize. Cortex moutan can clear away heat, cool blood, harmonize blood and eliminate blood stasis. Kochia scoparia can clear away heat and dampness, dispel wind and relieve itching. Cnidium monnieri can dry dampness and dispel wind, kill insects and relieve itching, warm the kidney and strengthen yang. Bear gall can clear the heart, relieve heat, soothe the liver, promote bile, dissolve stones and improve eyesight.

[0163] Ingredients of Kuyin Ganfu Decoction: Sophora flavescens 30-35g, Phragmites australis 30-35g, Honeysuckle 30-35g, Forsythia suspensa 15-20g, Scutellaria baicalensis 15-20g, Licorice 15-20g, Moutan bark 15-20g, Kochia scoparia 10g, Cnidium monnieri 10g, bear bile powder 0.3g; Usage: Add 2000ml of water, boil and simmer for 30 minutes, pour into a foot basin, cool to between 35℃ and 40℃, soak the affected hands and feet for 20 minutes, twice a day.

[0164] This is one of the cases. After oral capecitabine treatment, the patient developed severe hand-foot syndrome. The patient had obvious erythema and desquamation on the hands and feet. The changes were before and after 5 days of use.

[0165] Figure 3 Before oral capecitabine treatment.

[0166] Figure 4 After 7 days of oral capecitabine treatment.

[0167] This is another case where a patient developed severe hand-foot syndrome after oral sorafenib treatment. The patient had obvious erythema and desquamation on his hands and feet. The changes were before and after 10 days of use.

[0168] Figure 5 Before oral sorafenib treatment.

[0169] Figure 6 After 7 days of oral sorafenib treatment.

[0170] Kuyin Ganfu Decoction is used to treat hand-foot syndrome that occurs after patients receive anti-tumor treatment.

[0171] A total of 56 patients with hand-foot syndrome were collected clinically and divided into two groups, with 28 cases in each group. One group used the skin protectant vaseline ointment, and the other group used Kuyin Ganfu Decoction. It was used twice a day. The therapeutic effects of the two groups were observed after 7 days of treatment. The results showed that the erythema and desquamation of the hands and feet of patients in the Kuyin Ganfu Decoction group were significantly improved compared with those in the control group, and the difference was statistically significant.

[0172] Table 1 Comparison of the effects of the two groups in treating hand-foot syndrome

[0173]

[0174] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent substitutions and improvements made by any technician familiar with the technical field within the technical scope disclosed by the present invention and within the spirit and principle of the present invention should be covered by the protection scope of the present invention.

Claims

1. A Kuyin Ganfu Decoction formula for treating hand-foot syndrome, characterized in that: Includes the following ingredients: Sophora flavescens 30-35g, Phragmites australis 30-35g, Honeysuckle 30-35g, Forsythia suspensa 15-20g, Scutellaria baicalensis 15-20g, Licorice 15-20g, Cortex Moutan 15-20g, Kochia scoparia 10g, Cnidium monnieri 10g, and bear bile powder 0.3g.

2. A method for preparing the Kuyin Ganfu Decoction for treating hand-foot syndrome according to claim 1, characterized in that: The method for preparing the Kuyin Ganfu Decoction for treating hand-foot syndrome comprises: Step 1, mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder, and add 2000ml of water; Step 2, simmer for 30 minutes after boiling, then pour into the footbath; Step 3, cool down to between 35℃ and 40℃, soak the affected hands and feet for 20 minutes, twice a day.

3. A system for preparing the Kuyin Ganfu Decoction for treating hand-foot syndrome that implements the method for preparing the Kuyin Ganfu Decoction for treating hand-foot syndrome as claimed in claim 2, characterized in that: The Kuyin Ganfu Decoction prescription preparation system for treating hand-foot syndrome comprises: A mixing module is used to mix 30-35g of Sophora flavescens, 30-35g of Phragmites australis, 30-35g of Honeysuckle, 15-20g of Forsythia suspensa, 15-20g of Scutellaria baicalensis, 15-20g of Licorice, 15-20g of Cortex Moutan, 10g of Kochia scoparia, 10g of Cnidium monnieri, and 0.3g of Bear Bile Powder and add 2000ml of water; The decoction module is used to fry the food and then cook it for 30 minutes after boiling, and then pour it into the footbath; The cooling module is used to cool the body to between 35°C and 40°C and soak the affected hands and feet for 20 minutes, twice a day.

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