AIDS prevention and treatment blood sampling detection equipment

Abstract

The invention relates to the technical field of AIDS prevention and treatment blood sampling detection, and discloses AIDS prevention and treatment blood sampling detection equipment which comprises a shell mechanism, the shell mechanism comprises a shell, a display screen, an indicator light and an operation button, the display screen is installed on the front end face of the shell, the indicator light is arranged on the right side of the display screen, and the operation button is arranged on the right side of the display screen. By means of the blood sampling mechanism, the sample transfer mechanism and the control mechanism, when blood is sampled, the microprocessor accurately controls the puncturing depth and the blood sampling speed of the microneedle array according to feedback signals of the pressure sensor, and the blood sampling speed of the microneedle array can be accurately controlled according to the feedback signals of the pressure sensor. According to the device, the safety, stability and high efficiency of the blood sampling process are ensured, during detection, all parts of the device operate efficiently and stably under the coordination control of the control mechanism, automatic and intelligent operation from blood sampling to detection analysis is achieved, and the blood detection efficiency and accuracy in AIDS prevention and treatment work are improved.

Description

Technical Field

[0001] The invention relates to the technical field of blood sampling and detection for AIDS prevention and treatment, in particular to blood sampling and detection equipment for AIDS prevention and treatment. Background Art

[0002] As a global infectious disease that seriously threatens human health, the prevention and treatment of AIDS is of vital importance. At present, traditional AIDS blood testing devices have many limitations. In the blood collection process, the commonly used blood collection needles have a large diameter, which will cause obvious pain to the patient during puncture, and it is easy to cause damage to the tissues around the blood collection site, increasing the risk of infection. At the same time, the control of the blood collection volume during the blood collection process is not precise enough, which may lead to too much or too little sample volume, affecting the accuracy and efficiency of subsequent testing.

[0003] During the sample transfer process, due to the lack of effective sealing and anti-pollution measures, blood samples are extremely susceptible to contamination by bacteria, viruses, dust and other impurities in the external environment, which causes deviations in the test results and fails to truly reflect the patient's physical condition.

[0004] In addition, most existing detection devices are single-function and can only perform simple antibody or antigen detection. They are unable to conduct comprehensive and in-depth analysis of key indicators such as HIV nucleic acid, viral load, and drug-resistant genes, making it difficult to meet the needs of modern AIDS prevention and treatment for accurate diagnosis and personalized treatment. Moreover, the entire detection process is cumbersome and requires professionals to spend a lot of time and energy, which is not conducive to large-scale screening and rapid diagnosis of AIDS, and to some extent hinders the effective implementation of AIDS prevention and treatment.

[0005] In order to solve the above problems, this application proposes a blood sampling and testing device for AIDS prevention and treatment. Summary of the invention

[0006] The purpose of the present invention is to provide a blood sampling and testing device for the prevention and treatment of AIDS, so as to solve the problems in the prior art proposed in the above background technology, that the puncture will cause obvious pain to the patient, and it is easy to cause damage to the tissues around the blood collection site, increase the risk of infection, and the control of the blood collection volume during the blood collection process is not precise enough, which may lead to too much or too little sample volume, affecting the accuracy and efficiency of subsequent tests, and most of the detection devices have a single function.

[0007] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: A blood sampling and testing device for AIDS prevention and treatment, comprising a shell mechanism, the shell mechanism comprising a shell, a display screen, an indicator light and an operation button, the display screen is installed on the front end face of the shell, the indicator light is provided on the right side of the display screen, the operation button is provided below the display screen, the indicator light and the operation button are both fixedly connected to the shell mechanism, a blood collection mechanism is also installed on the shell mechanism, a sample transfer mechanism is installed on the shell mechanism, an analysis mechanism is installed on the inner side of the shell mechanism, a control mechanism is installed on the inner side of the shell mechanism, and a power supply is fixedly connected to the inner side wall of the top end of the shell.

[0008] Furthermore, the sample transfer mechanism includes a flexible microfluidic pipeline, a vacuum insulation chamber, a Peltier temperature controller, a mixing component and a sample storage tube; the vacuum insulation chamber is fixedly connected to the inner side of the outer shell, the sample storage tube is fixedly connected to the inner side of the top of the vacuum insulation chamber, the Peltier temperature controller is sleeved on the outer side of the sample storage tube, the mixing component is installed on the sample storage tube, and the flexible microfluidic pipeline is fixedly connected to the inner side of the sample storage tube.

[0009] Furthermore, the mixing assembly includes a motor B and an eccentric disk, the motor B is fixedly connected to the bottom end of the vacuum insulation chamber, the output end of the motor B passes through the surface of the vacuum insulation chamber and the sample storage tube, and the output end of the motor B is fixedly connected to the eccentric disk.

[0010] Furthermore, the blood collection mechanism includes a microneedle array, a pressure sensor, an anticoagulation microchannel, a fixing component, a transmission component and a handle, the other end of the flexible microfluidic pipeline is fixedly connected to the anticoagulation microchannel, the other end of the anticoagulation microchannel is fixedly connected to the microneedle array, the transmission component is installed on the outside of the microneedle array, the fixing component is installed on the transmission component, the handle is installed on the outside of the transmission component, and the pressure sensor is installed on the handle.

[0011] Furthermore, the transmission assembly includes a moving seat, a limiting rod, a sleeve, a screw and a motor A. A sliding groove is opened on the inner side of the handle, and the moving seat is slidably connected to the inner side of the sliding groove. The rear end face of the moving seat is fixedly connected to the limiting rod, the rear end face of the moving seat is fixedly connected to the sleeve, the screw is threadedly connected to the inner side of the sleeve, the rear end of the screw is fixedly connected to the motor A, and the outer side of the motor A is fixedly connected to the handle.

[0012] Furthermore, the fixing assembly includes a swivel seat, a swivel rod, a pressure rod, a pressure strip, a connecting rod, a positioning seat and a buckle. The swivel seat is installed on the front end face of the movable seat, the swivel rod is fixedly connected to the inner side of the swivel seat, both ends of the swivel rod are fixedly connected to the pressure rod, the rear end face of the pressure rod is fixedly connected to the pressure strip, the other end of the pressure rod is fixedly connected to the connecting rod, the right end of the connecting rod is fixedly connected to the positioning seat, the front end face of the movable seat is rotatably connected to the buckle via a rotating shaft, a slot is provided at the right end of the positioning seat, the movement trajectory of the buckle is arc-shaped, and the positioning seat is arranged on the movement trajectory of the buckle.

[0013] Furthermore, the analysis mechanism includes a sample pretreatment unit, a reaction amplification unit, a signal detection unit, a microfluidic chip, a microelectrode array and an optical sensor; the microfluidic chip is fixedly connected to the sample storage tube, the sample pretreatment unit is installed on the other end of the microfluidic chip, the reaction amplification unit is installed on one side of the sample pretreatment unit, the signal detection unit is installed on one side of the reaction amplification unit, the microelectrode array is installed on one side of the reaction amplification unit, and the optical sensor is installed on one side of the microelectrode array.

[0014] Furthermore, the control mechanism includes a microprocessor, a data storage chip and a wireless communicator, and the microprocessor, the data storage chip and the wireless communicator are installed inside the shell.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] The present invention provides a blood sampling mechanism, a sample transfer mechanism and a control mechanism. During the blood sampling process, the microprocessor accurately controls the penetration depth and blood sampling speed of the microneedle array according to the feedback signal of the pressure sensor, thereby ensuring the safety, stability and efficiency of the blood sampling process. The collected blood sample flows rapidly and smoothly into the flexible microfluidic pipeline through the anticoagulant microchannel under the action of a weak negative pressure. During the entire detection process, the various components of the device operate efficiently and stably under the coordinated control of the control mechanism, realizing automated and intelligent operations from blood sampling to detection and analysis, greatly improving the efficiency and accuracy of blood detection in AIDS prevention and treatment work, and providing a strong technical guarantee for the early diagnosis of AIDS, disease monitoring and formulation of treatment plans. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic diagram of the overall structure of a blood sampling and testing device for AIDS prevention and treatment according to the present invention;

[0018] Figure 2 This is a schematic diagram of the installation structure of a blood sampling mechanism of a blood sampling and testing device for AIDS prevention and treatment according to the present invention;

[0019] Figure 3 A side view of the installation structure of a blood sampling mechanism of a blood sampling and testing device for AIDS prevention and treatment according to the present invention;

[0020] Figure 4 This is a schematic diagram of the installation structure of a fixed component of a blood sampling and testing device for AIDS prevention and treatment according to the present invention;

[0021] Figure 5 This is a schematic diagram of the installation structure of a transmission component of an AIDS prevention and treatment blood sampling and testing device of the present invention;

[0022] Figure 6 This is a schematic diagram of the installation structure of a sample transfer mechanism of a blood sampling and testing device for AIDS prevention and treatment according to the present invention;

[0023] Figure 7 This is a schematic diagram of the installation structure of an analysis mechanism of an AIDS prevention and treatment blood sampling and testing device of the present invention;

[0024] Figure 8 This is a schematic diagram of the installation structure of a control mechanism of an AIDS prevention and treatment blood sampling and testing device of the present invention;

[0025] Fig. 9 This is a schematic diagram of the installation structure of a housing mechanism of an AIDS prevention and treatment blood sampling and testing device of the present invention;

[0026] In the figure:

[0027] 1. Blood collection mechanism; 11. Microneedle array; 12. Pressure sensor; 13. Anticoagulant microchannel; 14. Fixing assembly; 141. Rotating seat; 142. Rotating rod; 143. Pressing rod; 144. Pressing strip; 145. Connecting rod; 146. Positioning seat; 147. Buckle; 15. Transmission assembly; 151. Moving seat; 152. Limiting rod; 153. Sleeve; 154. Screw; 155. Motor A; 16. Handle;

[0028] 2. Sample transfer mechanism; 21. Flexible microfluidic pipeline; 22. Vacuum insulation chamber; 23. Peltier temperature controller; 24. Mixing assembly; 241. Motor B; 242. Eccentric disk; 25. Sample storage tube;

[0029] 3. Analysis mechanism; 31. Sample pretreatment unit; 32. Reaction amplification unit; 33. Signal detection unit; 34. Microfluidic chip; 35. Microelectrode array; 36. Optical sensor;

[0030] 4. Control mechanism; 41. Microprocessor; 42. Data storage chip; 43. Wireless communication device;

[0031] 5. Power supply;

[0032] 6. Shell mechanism; 61. Shell; 62. Display screen; 63. Indicator light; 64. Operation button. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0034] See also Figure 1-Figure 9 The present invention provides a technical solution: a blood sampling and testing device for AIDS prevention and treatment, including a shell mechanism 6, the shell mechanism 6 includes a shell 61, a display screen 62, an indicator light 63 and an operation button 64, a display screen 62 is installed on the front end surface of the shell 61, an indicator light 63 is arranged on the right side of the display screen 62, an operation button 64 is arranged below the display screen 62, the indicator light 63 and the operation button 64 are both fixedly connected to the shell mechanism 6, a blood sampling mechanism 1 is also installed on the shell mechanism 6, a sample transfer mechanism 2 is installed on the shell mechanism 6, an analysis mechanism 3 is installed on the inner side of the shell mechanism 6, a control mechanism 4 is installed on the inner side of the shell mechanism 6, and a power supply 5 is fixedly connected to the inner side wall of the top end of the shell 61.

[0035] The sample transfer mechanism 2 includes a flexible microfluidic pipeline 21, a vacuum insulation chamber 22, a Peltier temperature controller 23, a mixing component 24 and a sample storage tube 25. The vacuum insulation chamber 22 is fixedly connected to the inner side of the outer shell 61, the sample storage tube 25 is fixedly connected to the inner side of the top of the vacuum insulation chamber 22, the Peltier temperature controller 23 is sleeved on the outer side of the sample storage tube 25, the mixing component 24 is installed on the sample storage tube 25, and the flexible microfluidic pipeline 21 is fixedly connected to the inner side of the sample storage tube 25.

[0036] The mixing assembly 24 includes a motor B241 and an eccentric disk 242. The motor B241 is fixedly connected to the bottom of the vacuum insulation chamber 22. The output end of the motor B241 penetrates the surface of the vacuum insulation chamber 22 and the sample storage tube 25. The output end of the motor B241 is fixedly connected to the eccentric disk 242.

[0037] The blood collection mechanism 1 includes a microneedle array 11, a pressure sensor 12, an anticoagulation microchannel 13, a fixing component 14, a transmission component 15 and a handle 16. The other end of the flexible microfluidic pipeline 21 is fixedly connected to the anticoagulation microchannel 13, and the other end of the anticoagulation microchannel 13 is fixedly connected to the microneedle array 11. The transmission component 15 is installed on the outside of the microneedle array 11, and the fixing component 14 is installed on the transmission component 15. The handle 16 is installed on the outside of the transmission component 15, and the pressure sensor 12 is installed on the handle 16.

[0038] The transmission assembly 15 includes a moving seat 151, a limiting rod 152, a sleeve 153, a screw 154 and a motor A155. A sliding groove is opened on the inner side of the handle 16, and the moving seat 151 is slidably connected to the inner side of the sliding groove. The rear end face of the moving seat 151 is fixedly connected to the limiting rod 152, and the rear end face of the moving seat 151 is fixedly connected to the sleeve 153. The inner side of the sleeve 153 is threadedly connected to the screw 154, and the rear end of the screw 154 is fixedly connected to the motor A155, and the outer side of the motor A155 is fixedly connected to the handle 16.

[0039] The fixing assembly 14 includes a swivel seat 141, a swivel rod 142, a pressure rod 143, a pressure strip 144, a connecting rod 145, a positioning seat 146 and a buckle 147. The swivel seat 141 is installed on the front end face of the movable seat 151, the swivel rod 142 is fixedly connected to the inner side of the swivel seat 141, both ends of the swivel rod 142 are fixedly connected to the pressure rod 143, the rear end face of the pressure rod 143 is fixedly connected to the pressure strip 144, the other end of the pressure rod 143 is fixedly connected to the connecting rod 145, the right end of the connecting rod 145 is fixedly connected to the positioning seat 146, the front end face of the movable seat 151 is rotatably connected to the buckle 147 through a rotating shaft, a slot is provided at the right end of the positioning seat 146, the movement trajectory of the buckle 147 is arc-shaped, and the positioning seat 146 is arranged on the movement trajectory of the buckle 147.

[0040] The analysis mechanism 3 includes a sample pretreatment unit 31, a reaction amplification unit 32, a signal detection unit 33, a microfluidic chip 34, a microelectrode array 35 and an optical sensor 36. The microfluidic chip 34 is fixedly connected to the sample storage tube 25, and the sample pretreatment unit 31 is installed on the other end of the microfluidic chip 34. The reaction amplification unit 32 is installed on one side of the sample pretreatment unit 31, the signal detection unit 33 is installed on one side of the reaction amplification unit 32, the microelectrode array 35 is installed on one side of the reaction amplification unit 32, and the optical sensor 36 is installed on one side of the microelectrode array 35.

[0041] The control mechanism 4 includes a microprocessor 41 , a data storage chip 42 and a wireless communicator 43 , and the microprocessor 41 , the data storage chip 42 and the wireless communicator 43 are installed inside the housing 61 .

[0042] Working principle:

[0043] When in use, the power supply 5 is connected to an external power supply to power the device. The medical staff first takes out the blood sampling mechanism 1 from the device housing 61, holds the handle 16, and gently aligns the microneedle array 11 with the patient's blood sampling site. At this time, the pressure sensor 12 monitors the pressure changes between the microneedle array 11 and the skin in real time, and transmits the signal to the microprocessor 41 in the control mechanism 4. When the pressure reaches the preset starting blood sampling pressure value, the microprocessor 41 issues an instruction to start the transmission component 15, and the motor A155 drives the screw 154 to rotate. Through the limit rod 152 to limit the moving seat 151, the screw 154 drives the sleeve 153 away from the motor A155, and the motor A155 drives the moving seat 151 to move, so that the moving seat 151 drives the microneedle array 11 to slowly penetrate the dermis of the skin. During the blood sampling process, the microprocessor 41 accurately controls the penetration depth and blood sampling speed of the microneedle array 11 according to the feedback signal of the pressure sensor 12, ensuring the safety, stability and efficiency of the blood sampling process;

[0044] The collected blood sample flows into the flexible microfluidic pipe 21 quickly and smoothly through the anticoagulant microchannel 13 under the action of weak negative pressure. When the blood sample is transmitted in the flexible microfluidic pipe 21, the middle layer of the flexible microfluidic pipe 21 is provided with antibacterial agents and antioxidants, which effectively prevent the invasion of pollutants such as bacteria and viruses and the oxidation of blood samples by oxygen, thereby ensuring the purity and integrity of the sample. The sample smoothly enters the inner side of the sample storage tube 25 in the vacuum insulation chamber 22, and the Peltier temperature controller 23 quickly adjusts the temperature in the chamber and stabilizes it within the range of 2-8°C. The vacuum insulation chamber 22 keeps the sample storage tube 25 warm, and the mixing component 24 is started every 30 minutes to gently stir the sample to ensure the uniformity and stability of the sample, thereby providing reliable sample protection for subsequent detection and analysis.

[0045] When a test is required, the medical staff selects the corresponding test items and parameter settings on the display screen 62 by operating the button 64. After the microprocessor 41 receives the instruction, the relevant components in the sample transfer mechanism 2 transfer the blood sample from the sample storage tube 25 into the microfluidic chip 34, firstly remove impurities through the micromechanical filtration device in the sample pretreatment unit 31, and then accurately distribute it to each reaction amplification unit 32 through the microfluidic channel of the microfluidic chip 34 using the microdroplet technology. According to different test items, such as when performing PCR testing, the temperature control module in the reaction amplification unit 32, under the control of the microprocessor 41, quickly and accurately realizes the cycle control of the reaction temperature to perform nucleic acid amplification. Increase reaction; during the immune detection process, the microelectrode array 35 and the optical sensor 36 monitor the changes of electrical signals and optical signals in the immune reaction process in real time, and transmit these signals to the microprocessor 41. The microprocessor 41 processes and analyzes the received signals, obtains accurate detection results according to the preset algorithm and standard curve, and displays the results on the display screen 62. At the same time, the detection results and related data are transmitted in real time to the hospital's information management system HIS, the epidemic monitoring platform of the Center for Disease Control and Prevention or the telemedicine diagnosis center through the wireless communication device 43, so as to realize the rapid sharing of detection data and remote consultation, and provide timely and accurate data support and decision-making basis for the prevention and control of AIDS.

Claims

1. A blood sampling and testing device for AIDS prevention and treatment, characterized by: The invention comprises a shell mechanism (6), wherein the shell mechanism (6) comprises a shell (61), a display screen (62), an indicator light (63) and an operation button (64); the display screen (62) is installed on the front end surface of the shell (61); the indicator light (63) is provided on the right side of the display screen (62); the operation button (64) is provided below the display screen (62); the indicator light (63) and the operation button (64) are both fixedly connected to the shell mechanism (6); a blood sampling mechanism (1) is also installed on the shell mechanism (6); a sample transfer mechanism (2) is installed on the shell mechanism (6); an analysis mechanism (3) is installed on the inner side of the shell mechanism (6); a control mechanism (4) is installed on the inner side of the shell mechanism (6); and a power source (5) is fixedly connected to the inner side wall at the top end of the shell (61).

2. The AIDS prevention and treatment blood sampling and testing equipment according to claim 1, characterized in that: The sample transfer mechanism (2) comprises a flexible microfluidic pipeline (21), a vacuum insulation chamber (22), a Peltier temperature controller (23), a mixing component (24) and a sample storage tube (25); the inner side of the outer shell (61) is fixedly connected to the vacuum insulation chamber (22); the inner side of the top of the vacuum insulation chamber (22) is fixedly connected to the sample storage tube (25); the outer side of the sample storage tube (25) is sleeved with the Peltier temperature controller (23); the mixing component (24) is installed on the sample storage tube (25); and the inner side of the sample storage tube (25) is fixedly connected to the flexible microfluidic pipeline (21).

3. The AIDS prevention and treatment blood sampling and testing equipment according to claim 2, characterized in that: The mixing assembly (24) comprises a motor B (241) and an eccentric disk (242); the motor B (241) is fixedly connected to the bottom end of the vacuum insulation chamber (22); the output end of the motor B (241) penetrates the surface of the vacuum insulation chamber (22) and the sample storage tube (25); and the output end of the motor B (241) is fixedly connected to the eccentric disk (242).

4. The AIDS prevention and treatment blood sampling and testing equipment according to claim 2, characterized in that: The blood sampling mechanism (1) comprises a microneedle array (11), a pressure sensor (12), an anticoagulation microchannel (13), a fixing component (14), a transmission component (15) and a handle (16); the other end of the flexible microfluidic pipeline (21) is fixedly connected to the anticoagulation microchannel (13); the other end of the anticoagulation microchannel (13) is fixedly connected to the microneedle array (11); the transmission component (15) is installed on the outside of the microneedle array (11); the fixing component (14) is installed on the transmission component (15); the handle (16) is installed on the outside of the transmission component (15); and the pressure sensor (12) is installed on the handle (16).

5. The AIDS prevention and treatment blood sampling and testing equipment according to claim 4, characterized in that: The transmission assembly (15) comprises a moving seat (151), a limiting rod (152), a sleeve (153), a screw (154) and a motor A (155); a slide groove is provided on the inner side of the handle (16); the moving seat (151) is slidably connected to the inner side of the slide groove; the limiting rod (152) is fixedly connected to the rear end face of the moving seat (151); the sleeve (153) is fixedly connected to the rear end face of the moving seat (151); the screw (154) is threadedly connected to the inner side of the sleeve (153); the motor A (155) is fixedly connected to the rear end of the screw (154); and the outer side of the motor A (155) is fixedly connected to the handle (16).

6. The AIDS prevention and treatment blood sampling and testing equipment according to claim 5, characterized in that: The fixing assembly (14) comprises a rotating seat (141), a rotating rod (142), a pressure rod (143), a pressure strip (144), a connecting rod (145), a positioning seat (146) and a buckle (147); the rotating seat (141) is installed on the front end surface of the movable seat (151); the rotating rod (142) is fixedly connected to the inner side of the rotating seat (141); both ends of the rotating rod (142) are fixedly connected to the pressure rod (143); the rear end surface of the pressure rod (143) is fixedly connected to the positioning seat (146) and the positioning seat (146) The pressure bar (144) is provided, the other end of the pressure rod (143) is fixedly connected to the connecting rod (145), the right end of the connecting rod (145) is fixedly connected to the positioning seat (146), the front end surface of the movable seat (151) is rotatably connected to the buckle (147) via a rotating shaft, a clamping groove is provided at the right end of the positioning seat (146), the movement trajectory of the buckle (147) is arc-shaped, and the positioning seat (146) is arranged on the movement trajectory of the buckle (147).

7. The AIDS prevention and treatment blood sampling and testing equipment according to claim 3, characterized in that: The analysis mechanism (3) comprises a sample pretreatment unit (31), a reaction amplification unit (32), a signal detection unit (33), a microfluidic chip (34), a microelectrode array (35) and an optical sensor (36); the microfluidic chip (34) is fixedly connected to the sample storage tube (25); the sample pretreatment unit (31) is installed at the other end of the microfluidic chip (34); the reaction amplification unit (32) is installed at one side of the sample pretreatment unit (31); the signal detection unit (33) is installed at one side of the reaction amplification unit (32); the microelectrode array (35) is installed at one side of the reaction amplification unit (32); and the optical sensor (36) is installed at one side of the microelectrode array (35).

8. The AIDS prevention and treatment blood sampling and testing equipment according to claim 1, characterized in that: The control mechanism (4) comprises a microprocessor (41), a data storage chip (42) and a wireless communicator (43), and the microprocessor (41), the data storage chip (42) and the wireless communicator (43) are installed inside the housing (61).

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