External traditional Chinese medicine composition for treating sport injury and chronic pain and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine extraction, in particular to an external traditional Chinese medicine composition for treating sport injury and chronic pain and a preparation method of the external traditional Chinese medicine composition. The preparation method comprises the following steps: extracting other components including monkshood, cassia twig, clove, liquorice, safflower, caulis sinomenii and peach kernel with ethanol for multiple times to obtain a traditional Chinese medicine extracting solution, and compounding the traditional Chinese medicine extracting solution with the agilawood extract to obtain the plant small-molecule traditional Chinese medicine composition. The traditional Chinese medicine composition directly permeates through skin and intercellular space to reach a focus and a target spot, accelerates basic metabolism through lymphatic circulation, can quickly remove inflammation, relieve swelling and pain, release adhesion, repair damaged tissues and accelerate regeneration of damaged tissue cells, has a remarkable curative effect on sport injury, chronic pain and the like, and is free of toxic and side effects. And the raw materials are pure plants, are safe and free of side effects, are easy for large-scale production, and have very good market application prospects.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine extraction, and in particular to an external Chinese medicine composition for treating sports injuries and chronic pain and a preparation method thereof. Background Art

[0002] Pain is a comprehensive emotional experience that includes the psychological feeling caused by actual or potential tissue damage and the accompanying related emotions such as frustration, irritability and even despair. Pain can be divided into acute pain and chronic pain according to its duration and nature. When the pain lasts for 3 to 6 months or more, acute pain will turn into chronic pain. Chronic pain, such as cervical spondylosis, lumbar disc herniation, frozen shoulder, lumbar muscle strain, arthritis, postherpetic neuralgia, bursitis, ganglion cyst, myofasciitis, etc., is one of the most common problems affecting people's health. According to statistics, about 11% to 40% of the world's population suffers from chronic pain. Chronic pain can cause dysfunction of various organ systems in the body, damage the immune system, increase the possibility of malignant diseases, and increase the risk of mental illnesses such as anxiety, depression, and sleep disorders. In addition, chronic pain caused by low back pain, musculoskeletal diseases and neck pain is the main cause of disability, seriously affecting the quality of life of patients and causing great economic and medical burdens.

[0003] At present, the research on the mechanism of pain generation has found that the generation of pain is mainly related to the plastic changes of the central nervous system and the ectopic afferent electrical activity of peripheral primary sensory neurons. In the drug treatment of pain, opioids and non-steroidal analgesics are traditional analgesics that are widely used in clinical practice, but these analgesics are accompanied by various side effects. For example, opioids are highly addictive and easy to produce tolerance, leading to drug abuse; non-steroidal drugs have side effects such as multiple organ damage, gastrointestinal ulcers, and allergies, and long-term use is more harmful to the human body. Traditional Chinese medicine has great potential in the treatment of chronic pain. For example, acupuncture, massage, cupping, etc. have good therapeutic effects, but they require doctors with medical qualifications to operate, and the technical difficulty is relatively high. Therefore, it is of great significance to seek a safe, side-effect-free, effective, and easy-to-operate external treatment for chronic pain. Summary of the invention

[0004] The purpose of the present invention is to provide an external Chinese medicine composition for treating sports injuries and chronic pain and a preparation method thereof in view of the deficiencies of the prior art. The Chinese medicine composition prepared by the method adopts.

[0005] The purpose of the present invention is achieved through the following technical solutions:

[0006] Provided is a method for preparing an external Chinese medicine composition for treating sports injuries and chronic pain, comprising the following steps:

[0007] S1, crushing the agarwood block into 20-40 mesh agarwood powder, and then drying it for later use;

[0008] S2, feeding the dried agarwood powder into a supercritical CO2 extraction device, and after the CO2 is cooled into a liquid, it is pressurized and fed into the extraction device, and an ultrasonic device is turned on for extraction, and after the extraction is completed, an agarwood extract and a slag material are obtained;

[0009] S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling;

[0010] S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use;

[0011] S5. Weigh 6-15 parts of aconite root, 10-18 parts of cassia twig, 5-10 parts of clove, 6-15 parts of liquorice, 10-15 parts of safflower, 8-16 parts of Sinomenium sinensis and 10-18 parts of peach kernel, and dry and mix to obtain a mixture;

[0012] S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through a 60-100 mesh sieve to obtain traditional Chinese medicine powder;

[0013] S7, adding 6 to 8 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder and extracting twice, combining the extracts and filtering 2 to 3 times to obtain a clarified solution, and then centrifuging to obtain the supernatant to obtain a traditional Chinese medicine extract for standby use;

[0014] S8. Mix the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:(3-6) and then concentrate under vacuum to obtain a traditional Chinese medicine composition.

[0015] In the above technical solution, in step S1, drying is performed until the moisture content does not exceed 5%.

[0016] In the above technical solution, in step S2, during the supercritical CO2 extraction process, the extraction pressure is set to 25-35 MPa, the extraction temperature is set to 35-50°C, and the extraction time is set to 1-3 hours.

[0017] In the above technical solution, in step S2, the ultrasonic power is controlled to be 350-400W, and the ultrasonic time is controlled to be 1-2h.

[0018] In the above technical solution, in step S7, the centrifugal speed is 4000-6000 rpm, and the centrifugation time is 10-20 min.

[0019] The present invention also provides an external Chinese medicinal composition for treating sports injuries and chronic pain. The Chinese medicinal composition is prepared by the above-mentioned preparation method.

[0020] In the above technical solution, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient, wherein the excipient is at least one of a disintegrant, a lubricant and a binder.

[0021] In the above technical solution, the dosage form of the Chinese medicine composition is a gel or an ointment.

[0022] In the formula of the present invention:

[0023] Agarwood: It tastes spicy and bitter, is slightly warm in nature and enters the spleen, stomach and kidney meridians. It has the effects of promoting qi and relieving pain, warming the middle and stopping vomiting, and relieving asthma. Agarwood is the resin-containing wood of the white agarwood plant of the Thymelaeaceae family. Its main chemical components include lignans and volatile oils. For example, lignans mainly include aromatic butyrolactones and tetrahydrofurans. Aromatic butyrolactones have anti-inflammatory, analgesic and antiviral effects; volatile oils are a group of complex mixtures, characterized by aromatic odors, and have antibacterial and anti-inflammatory, antitussive and antiasthmatic, stomachic, antipyretic and antiviral effects. At present, the extraction process for agarwood mainly focuses on the volatile oil components extracted by steam distillation. This process often takes a long time to extract agarwood essential oil, has low extraction rate and active ingredient content, and is easily mixed with impurities such as residual plant wax and pigments.

[0024] Aconite: It tastes pungent and sweet, is very hot in nature, and enters the heart, kidney, and spleen meridians. It has the effects of restoring yang, replenishing fire and assisting yang, and dispersing cold and relieving pain.

[0025] Cinnamon twig: pungent, sweet, warm, enters the heart, lung, and bladder meridians, has the functions of sweating and relieving muscles, warming and unblocking meridians, and promoting yang and transforming qi. It is used for chest pain, palpitations, and irregular pulse caused by weak chest yang and obstruction of heart meridians. Studies have shown that cinnamaldehyde contained in cinnamon twig has a certain degree of analgesic effect.

[0026] Clove: pungent, warm, enters the spleen, stomach, lung, and kidney meridians, warms the middle and lowers adverse effects, nourishes the kidney and strengthens yang, and can be used for spleen and stomach deficiency and cold, hiccups and vomiting, loss of appetite, vomiting and diarrhea, cold pain in the heart and abdomen, and impotence due to kidney deficiency. Studies have shown that clove has a significant analgesic effect in acetic acid writhing, formalin, and hot plate experiments in mice.

[0027] Licorice: sweet in taste, neutral in nature, and enters the heart, lung, spleen, and stomach meridians. In addition to the effects of tonifying the spleen and replenishing qi, moistening the lungs and relieving cough, clearing away heat and detoxifying, and harmonizing various medicines, it is also used for symptoms such as sore throat, spleen and stomach deficiency and cold, peptic ulcer, and poisoning.

[0028] Safflower: pungent, warm, enters the heart and liver meridians. It is used for swelling and pain caused by blood stasis due to falls, rib pain caused by blood stasis, carbuncle and hematemesis with blood stasis. It can be used together with peach kernel, frankincense, myrrh, etc.

[0029] Sinomenine: bitter, pungent, neutral, enters the liver and spleen meridians, has the effects of removing rheumatism, unblocking meridians, and promoting urination. It is used for rheumatic arthralgia, joint swelling, rheumatic numbness, edema, beriberi and other diseases. Its active ingredient, Sinomenine, has anti-inflammatory, analgesic, sedative, and immunosuppressive effects.

[0030] Peach kernel: bitter, sweet, flat, and enters the heart, liver, and large intestine meridians. It has the effects of promoting blood circulation and removing blood stasis, moistening the intestines and promoting bowel movements, and relieving cough and asthma.

[0031] Beneficial effects of the present invention:

[0032] The invention discloses an external Chinese medicine composition for treating sports injuries and chronic pain. The composition is prepared by mixing the Chinese medicinal material agarwood and 6-15 parts by weight of aconite root, 10-18 parts by weight of cassia twig, 5-10 parts by weight of clove, 6-15 parts by weight of liquorice root, 10-15 parts by weight of safflower root, 8-16 parts by weight of scutellaria baicalensis and 10-18 parts by weight of peach kernel. The active ingredients of agarwood can be fully and efficiently extracted by ultrasonic-assisted supercritical CO2 extraction process. The other components aconite root, cassia twig, clove, liquorice, safflower root, scutellaria baicalensis and peach kernel are subjected to steps such as multiple ethanol extraction to obtain a Chinese medicine extract. The Chinese medicine extract is compounded with the agarwood extract obtained by extraction and purification to form a plant small molecule Chinese medicine composition. , can be made into a gel or cream dosage product that matches the frequency of the ultrasonic drug delivery device. It does not pass through the digestive and blood circulation systems, but directly penetrates through the skin and cell gaps to reach the lesions and target sites, and accelerates basal metabolism through the lymphatic circulation without breaking the skin or damaging tissues. It can quickly eliminate inflammation, reduce swelling and relieve pain, loosen adhesions, repair damaged tissues, promote the metabolism of toxins and aseptic inflammation, improve local microcirculation, accelerate the regeneration of damaged tissue cells, and promote the division and proliferation of osteoblasts. It has significant therapeutic effects on sports injuries, chronic pain, etc. Moreover, the raw materials of the invention are all pure plants, safe and without side effects, easy to mass produce, and have very good market application prospects. DETAILED DESCRIPTION

[0033] The present invention is further described in conjunction with the following examples, but the present invention is not limited to the scope of the embodiments. After reading the present invention, various non-substantial modifications of the present invention by those skilled in the art fall within the scope defined by the appended claims of this application.

[0034] Example 1.

[0035] The preparation method of a Chinese medicine composition for external use for treating sports injuries and chronic pain in this embodiment comprises the following steps:

[0036] S1. Grind the agarwood block into 30 mesh agarwood powder, and then dry it until the moisture content does not exceed 5%;

[0037] S2, the dried agarwood powder is sent into a supercritical CO2 extraction device, CO2 is cooled into a liquid and then pressurized and sent into the extraction device, and the ultrasonic device is turned on at the same time, the ultrasonic power is controlled to 400W, the ultrasonic time is 1h for extraction, the extraction pressure is set to 30MPa, the extraction temperature is 40°C, the extraction time is 2h, and the agarwood extract and slag are obtained after the extraction is completed;

[0038] S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling;

[0039] S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use;

[0040] S5. Weigh 6 parts of aconite root, 10 parts of cassia twig, 10 parts of clove, 5 parts of liquorice, 10 parts of safflower, 8 parts of Sinomenium sinensis and 18 parts of peach kernel by weight, dry and mix well to obtain a mixture;

[0041] S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through an 80-mesh sieve to obtain traditional Chinese medicine powder;

[0042] S7, adding 8 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder and extracting twice, combining the extracts and filtering twice to obtain a clarified solution, and then centrifuging at 4000 rpm for 20 minutes, taking the supernatant to obtain a traditional Chinese medicine extract for standby use;

[0043] S8. After uniformly mixing the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:4, the mixture is concentrated under vacuum to obtain a traditional Chinese medicine composition.

[0044] As a preferred embodiment, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient and is made into a gel product. The excipient is a mixture of a disintegrant, a lubricant and a binder.

[0045] Example 2.

[0046] The preparation method of a Chinese medicine composition for external use for treating sports injuries and chronic pain in this embodiment comprises the following steps:

[0047] S1. Grind the agarwood block into 20-mesh agarwood powder, and then dry it until the moisture content does not exceed 5%;

[0048] S2, the dried agarwood powder is sent into a supercritical CO2 extraction device, CO2 is cooled into a liquid and then pressurized and sent into the extraction device, and the ultrasonic device is turned on at the same time, the ultrasonic power is controlled to 350W, the ultrasonic time is 2h for extraction, the extraction pressure is set to 35MPa, the extraction temperature is 50°C, the extraction time is 1h, and the agarwood extract and slag are obtained after the extraction is completed;

[0049] S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling;

[0050] S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use;

[0051] S5. Weigh 15 parts of aconite root, 18 parts of cassia twig, 5 parts of clove, 6 parts of liquorice, 15 parts of safflower, 16 parts of Sinomenium sinensis and 10 parts of peach kernel, and dry and mix them to obtain a mixture;

[0052] S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through a 60-mesh sieve to obtain traditional Chinese medicine powder;

[0053] S7, adding 6 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder and extracting twice, combining the extracts and filtering 3 times to obtain a clarified solution, and then centrifuging at 6000 rpm for 10 min, taking the supernatant to obtain a traditional Chinese medicine extract for standby use;

[0054] S8. After uniformly mixing the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:5, the mixture is concentrated under vacuum to obtain a traditional Chinese medicine composition.

[0055] As a preferred embodiment, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient and is made into a cream product. The excipient is a binder.

[0056] Example 3.

[0057] The preparation method of a Chinese medicine composition for external use for treating sports injuries and chronic pain in this embodiment comprises the following steps:

[0058] S1. Grind the agarwood block into 40 mesh agarwood powder, and then dry it until the moisture content does not exceed 5%;

[0059] S2, the dried agarwood powder is sent into a supercritical CO2 extraction device, CO2 is cooled into a liquid and then pressurized and sent into the extraction device, and the ultrasonic device is turned on at the same time, the ultrasonic power is controlled to 380W, the ultrasonic time is 1.5h for extraction, the extraction pressure is set to 25MPa, the extraction temperature is 35°C, the extraction time is 3h, and the agarwood extract and slag are obtained after the extraction is completed;

[0060] S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling;

[0061] S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use;

[0062] S5. Weigh 10 parts of aconite root, 12 parts of cassia twig, 8 parts of clove, 10 parts of liquorice, 12 parts of safflower, 10 parts of Sinomenium sinensis and 12 parts of peach kernel, and dry and mix them to obtain a mixture;

[0063] S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through a 60-mesh sieve to obtain traditional Chinese medicine powder;

[0064] S7, adding 8 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder for extraction twice, combining the extracts and filtering twice to obtain a clarified solution, and then centrifuging at 5000 rpm for 15 min, taking the supernatant to obtain a traditional Chinese medicine extract for standby use;

[0065] S8. After uniformly mixing the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:3, the mixture is concentrated under vacuum to obtain a traditional Chinese medicine composition.

[0066] As a preferred embodiment, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient and is made into a gel product. The excipient is a mixture of a lubricant and a binder.

[0067] Example 4.

[0068] The preparation method of a Chinese medicine composition for external use for treating sports injuries and chronic pain in this embodiment comprises the following steps:

[0069] S1. Grind the agarwood block into 30 mesh agarwood powder, and then dry it until the moisture content does not exceed 5%;

[0070] S2, the dried agarwood powder is sent into a supercritical CO2 extraction device, CO2 is cooled into a liquid and then pressurized and sent into the extraction device, and the ultrasonic device is turned on at the same time, the ultrasonic power is controlled to 400W, the ultrasonic time is 2h for extraction, the extraction pressure is set to 35MPa, the extraction temperature is 40°C, the extraction time is 2h, and the agarwood extract and slag are obtained after the extraction is completed;

[0071] S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling;

[0072] S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use;

[0073] S5. Weigh 12 parts of aconite root, 16 parts of cassia twig, 7 parts of clove, 13 parts of liquorice, 14 parts of safflower, 13 parts of Sinomenium sinensis and 15 parts of peach kernel, and dry and mix them to obtain a mixture;

[0074] S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through a 100-mesh sieve to obtain traditional Chinese medicine powder;

[0075] S7, adding 7 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder and extracting twice, combining the extracts and filtering 3 times to obtain a clarified solution, and then centrifuging at 6000 rpm for 18 minutes, taking the supernatant to obtain a traditional Chinese medicine extract for standby use;

[0076] S8. After uniformly mixing the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:6, the mixture is concentrated under vacuum to obtain a traditional Chinese medicine composition.

[0077] As a preferred embodiment, the Chinese medicine composition further comprises a pharmaceutically acceptable excipient and is prepared into a cream product. The excipient is a mixture of a disintegrant and a lubricant.

[0078] Performance test: The agarwood extract prepared in steps S1 to S4 of the above embodiments 1 to 4 was selected and sampled for analysis of its active substances using gas chromatography-mass spectrometry GC-MS.

[0079] The chromatographic conditions are as follows: the chromatographic column is RTX-5MS (30m×0.25mm×0.25μm), the injection temperature is 280°C, the injection volume is 1μl, and the flow rate is 1.0ml / min; the injection carrier gas is He, and the heating process is as follows: 80°C for 2min, heating to 160°C at 10°C / min, heating to 280°C at 3°C / min, and holding for 10min; the mass spectrometry conditions are as follows: electron energy 70eV, ion source temperature 250°C, and the contents of terpenes, chromones, aromatic compounds and fatty acids were determined, and the physical and chemical properties of the agarwood extract were observed. The results are shown in Table 1:

[0080] Table 1. Content of active ingredients in the agarwood extracts of Examples 1 to 4

[0081]

[0082] It can be seen from Table 1 that the total content of effective active substances in the agarwood extract obtained by the methods of Examples 1 to 4 can reach more than 81%, and the content of fatty acid compounds is low, the color is stable, and the quality is good, especially the content of hemiterpenoid compounds and chromone compounds is significantly increased.

[0083] Compared with the prior art, in the Chinese medicine composition of the present invention, the active ingredients of agarwood can be fully and efficiently extracted by ultrasonic-assisted supercritical CO2 extraction process, and the extracts of other components, such as aconite root, cassia twig, clove, liquorice, safflower, scutellaria baicalensis and peach kernel, are compounded to form a plant small molecule Chinese medicine composition, which can be made into a gel or cream dosage form product matching the frequency of an ultrasonic drug delivery device, and directly penetrates through the skin and intercellular spaces to reach the lesions and target sites without passing through the digestive and blood circulation systems, and accelerates basal metabolism through lymphatic circulation without breaking the skin or damaging tissues, thereby being able to quickly clear inflammation, reduce swelling and relieve pain, loosen adhesions, repair damaged tissues, promote metabolism of toxins and aseptic inflammation, improve local microcirculation, accelerate the regeneration of damaged tissue cells, and promote the division and proliferation of osteoblasts, and has significant therapeutic effects on sports injuries, chronic pain, etc. Moreover, the raw materials of the present invention are all pure plants, safe and without side effects, easy to mass produce, and have very good market application prospects.

[0084] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A method for preparing a Chinese medicine composition for external use for treating sports injuries and chronic pain, characterized in that: The following steps are involved: S1, crushing the agarwood block into 20-40 mesh agarwood powder, and then drying it for later use; S2, feeding the dried agarwood powder into a supercritical CO2 extraction device, and after the CO2 is cooled into a liquid, it is pressurized and fed into the extraction device, and an ultrasonic device is turned on for extraction, and after the extraction is completed, an agarwood extract and a slag material are obtained; S3, adding the slag and distilled water into a distillation kettle, heating and distilling, and obtaining a distilled extract after cooling; S4, combining the obtained agarwood extract and the distilled extract, filtering through a multi-stage filter to obtain an agarwood extract for standby use; S5. Weigh 6-15 parts of aconite root, 10-18 parts of cassia twig, 5-10 parts of clove, 6-15 parts of liquorice, 10-15 parts of safflower, 8-16 parts of Sinomenium sinensis and 10-18 parts of peach kernel, and dry and mix to obtain a mixture; S6, grinding the mixture using a traditional Chinese medicine powder grinder, passing through a 60-100 mesh sieve to obtain traditional Chinese medicine powder; S7, adding 6 to 8 times the mass concentration of 70% ethanol solution to the traditional Chinese medicine powder and extracting twice, combining the extracts and filtering 2 to 3 times to obtain a clarified solution, and then centrifuging to obtain the supernatant to obtain a traditional Chinese medicine extract for standby use; S8. Mix the agarwood extract and the traditional Chinese medicine extract in a mass ratio of 1:(3-6) and then concentrate under vacuum to obtain a traditional Chinese medicine composition.

2. The method for preparing a Chinese medicine composition for external use for treating sports injuries and chronic pain according to claim 1, characterized in that: In the step S1, drying is performed until the moisture content does not exceed 5%.

3. The method for preparing a Chinese medicine composition for external use for treating sports injuries and chronic pain according to claim 1, characterized in that: In step S2, during the supercritical CO2 extraction process, the extraction pressure is set to 25-35 MPa, the extraction temperature is set to 35-50°C, and the extraction time is set to 1-3 hours.

4. The method for preparing the external Chinese medicine composition for treating sports injuries and chronic pain according to claim 1, characterized in that: In step S2, the ultrasonic power is controlled to be 350-400 W, and the ultrasonic time is controlled to be 1-2 h.

5. The method for preparing the external Chinese medicine composition for treating sports injuries and chronic pain according to claim 1, characterized in that: In step S7, the centrifugal speed is 4000-6000 rpm, and the centrifugation is performed for 10-20 minutes.

6. A Chinese medicine composition for external use for treating sports injuries and chronic pain, characterized in that: The traditional Chinese medicine composition is prepared by the preparation method according to any one of claims 1 to 5.

7. A Chinese medicinal composition for external use for treating sports injuries and chronic pain according to claim 6, characterized in that: The traditional Chinese medicine composition also contains a pharmaceutically acceptable excipient, wherein the excipient is at least one of a disintegrant, a lubricant and a binder.

8. A Chinese medicinal composition for external use for treating sports injuries and chronic pain according to claim 6, characterized in that: The dosage form of the traditional Chinese medicine composition is gel or ointment.

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