A bionic skin biological composition and its application in cosmetics

Abstract

The present application provides a biomimetic skin biological composition composition, including: a film former, the film former including a hard film former, a soft film former and a solvent; a cell phospholipid membrane component, the cell phospholipid membrane component including polyquaternium-61, polyquaternium-65, a stabilizer and a solvent; the mass ratio of the film former and the cell phospholipid membrane component is 6~15:0.1. The present application also provides cosmetics including the above-mentioned composition. The present application is compounded with a film former including a hard film former and a soft film former and a cell phospholipid membrane component including polyquaternium-61 and polyquaternium-65, which has good anti-migration and anti-tearing effects, significantly improves the docility of the makeup product, and has a good makeup-holding effect; the composition has good flexibility after film formation, has a comfortable skin feel, can improve whiteness, gives the skin a natural luster, and does not affect the transdermal absorption of cosmetic active ingredients, helps to create skin care makeup, and realizes makeup and maintenance.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemicals, in particular to a bionic skin biological composition and application thereof in cosmetics. Background Art

[0002] Makeup products occupy an important position in the modern cosmetics market, among which the long-lasting effect is one of the key performances that consumers pay attention to. The development of long-lasting makeup technology aims to extend the durability of makeup products and reduce the loss of makeup caused by factors such as oil production, friction, and exaggerated facial expressions, so as to maintain the integrity and beauty of makeup. In the development of makeup long-lasting technology, the application of film formers has played a key role. Early film formers were mostly single ingredients, such as polyvinyl pyrrolidone (PVP) and trimethylsiloxysilicate, but their long-lasting effect was limited and the skin feel was not good. With the advancement of technology, composite film formers have gradually become a research hotspot. By compounding film formers of different properties, the advantages of each ingredient can be combined to enhance the long-lasting effect and improve the skin feel.

[0003] In the existing makeup lasting technology, the compounding of soft film and hard film formers is widely used. Soft film formers usually have good flexibility and skin affinity, and can provide a comfortable skin feel, but the makeup lasting effect is relatively weak when used alone; hard film formers have higher strength and stability, and can effectively fix makeup particles, but may cause skin tightness and discomfort. Therefore, the compounding of soft film and hard film formers can balance the makeup lasting effect and skin feel to a certain extent. For example, CN117379338A discloses a breathable long-lasting makeup liquid foundation suitable for sensitive skin, including a film former, an emulsifier, a thickener, a filler, a moisturizer, a colorant and an emollient; wherein the film former includes a hard film former trimethylsiloxysilicate and a soft film former isododecane (and) acrylic acid (ester) / polytrimethylsiloxane methacrylate copolymer, and the liquid foundation is breathable, thin, and does not feel sticky on the skin. However, the anti-migration effect of the liquid foundation is not significantly improved and still needs to be further improved. Summary of the invention

[0004] In view of this, the present invention provides a bionic skin biological composition and its application in cosmetics. The film formed by the bionic skin biological composition provided in the present application has good anti-migration effect, flexibility and anti-tear effect, does not affect the transdermal absorption of active ingredients, and has a comfortable skin feel.

[0005] The present application provides a bionic skin biological composition, comprising:

[0006] A film-forming agent, wherein the film-forming agent comprises a hard film-forming agent, a soft film-forming agent and a solvent in a mass ratio of 30-40:10-20:40-60;

[0007] A cell phospholipid membrane component, wherein the cell phospholipid membrane component comprises polyquaternium-61, polyquaternium-65, a stabilizer and a solvent in a mass ratio of 1-3:0.1-0.5:20-30:60-75;

[0008] The mass ratio of the film-forming agent to the cell phospholipid membrane component is 6-15:0.1.

[0009] The present application compounds a film-forming agent including a hard film-forming agent and a soft film-forming agent with a cell phospholipid membrane component including polyquaternium-61 and polyquaternium-65 to obtain a composition of bionic skin biological composition, which has good anti-migration and anti-tear effects, significantly improves the adherence of cosmetic products, and has a good makeup-lasting effect; after film formation, the composition has good flexibility, has a comfortable skin feel, can improve whitening, and does not affect the transdermal absorption of active ingredients in cosmetics, helps to create skin-nourishing cosmetics, and realizes makeup and care in one.

[0010] The biomimetic skin biological composition provided in the present application includes a film former, which can be used to maintain the integrity and beauty of the makeup. The film former includes a hard film former, a soft film former and a solvent in a mass ratio of 30~40:10~20:40~60, wherein the hard film former has high strength and stability and can effectively fix the makeup particles; the soft film former has good flexibility and skin affinity and can provide a comfortable skin feel. In some specific implementations, among the film formers, the hard film former includes but is not limited to trimethylsiloxysilicate, trifluoropropyl dimethyl / trimethylsiloxysilicate, polyvinyl pyrrolidone, polyvinyl alcohol, etc., and can be one or more of them. When the hard film former is a combination of multiple substances, the present application does not limit the proportion of each specific substance. In some specific implementations, the hard film former is preferably trimethylsiloxysilicate. The soft film former includes but is not limited to polypropyl silsesquioxane, acrylic acid (ester) / polydimethylsiloxane copolymer, acrylic acid (ester) / polytrimethylsiloxane methacrylate copolymer, VP / hexadecene copolymer, butyl acrylate / hydroxypropyl polydimethylsiloxane acrylate copolymer or polyurethane film former, etc., which can be one or more of them. When the soft film former is a combination of multiple substances, the present application does not limit the proportion of each specific substance. In some specific implementations, the soft film former is preferably polypropyl silsesquioxane. The solvent includes but is not limited to methyl polytrimethylsiloxane, polydimethylsiloxane, C13~15 alkane, C12~15 alcohol benzoate, cyclopentasiloxane and caprylic acid / capric triglyceride, etc., which can be one or more of them. When the solvent is a combination of multiple substances, the present application does not limit the proportion of each specific substance. In some specific implementations, the solvent is preferably methyl polytrimethylsiloxane. The mass ratio of the hard film forming agent, the soft film forming agent and the solvent is 30-40:10-20:40-60, preferably 35:15:50.

[0011] The biomimetic skin biological composition provided in the present application includes a cell phospholipid membrane component, which contains a hydrophilic phosphate group and a hydrophobic alkyl chain. Figure 1 , Figure 1It is a structural comparison diagram of cell phospholipid membrane and human cells. The cell phospholipid membrane shows a structure and function similar to that of human cells, has good biocompatibility, and can improve the makeup-lasting effect. In some specific implementations, the cell phospholipid membrane component includes polyquaternium-61, polyquaternium-65, stabilizer and solvent in a mass ratio of 1~3:0.1~0.5:20~30:60~75. Compared with the compounding of polyquaternium-61 and other polyquaternium components, the compounding of polyquaternium-61 and polyquaternium-65 can significantly improve the anti-migration ability of the composition. In some specific implementations, in the cell phospholipid membrane component, the stabilizer includes but is not limited to polyglycerol-3 polydimethylsiloxane hydroxyethyl polydimethylsiloxane, polyglycerol-3 oleate, polyglycerol-3 diisostearate, diisostearyl polyglycerol-3 dimer linoleate, polyglycerol-6 polyricinoleate, glyceryl stearate, etc., which can be one or more of them. When the stabilizer is a combination of multiple substances, the present application does not limit the proportion of each specific substance. In some specific implementations, the stabilizer is preferably polyglycerol-3 polydimethylsiloxane hydroxyethyl polydimethylsiloxane. The solvent includes but is not limited to isododecane, squalane, coconut oil alcohol-caprylate / caprate, tri(ethylhexanoic acid) glyceryl ester, caprylic / capric glyceride and isononanoic acid isononyl ester, etc., which can be one or more of them. When the solvent is a combination of multiple substances, the present application does not limit the proportion of each specific substance. In some specific implementations, the solvent is preferably caprylic acid / capric acid glycerides and isononyl isononanoate in a mass ratio of 1-5:65-75. In some specific implementations, the mass ratio of polyquaternium-61, polyquaternium-65, stabilizer and solvent is 1-3:0.1-0.5: 20-30:60-75, preferably 2:0.3:25:72.7.

[0012] In some specific implementations, the mass ratio of the film former and the cell phospholipid membrane component is 6-15:0.1. At this ratio, the film former and the cell phospholipid membrane component show a synergistic effect, which is significantly different from the film former or the cell phospholipid membrane component, and can enhance the anti-migration effect of the composition. Preferably, the mass ratio of the film former and the cell phospholipid membrane component is 8-10:0.1. At this ratio, the film former and the cell phospholipid membrane component show a synergistic effect, which can greatly enhance the anti-migration effect of the composition when the dosage is the same, and has significant differences compared to the film former and the cell phospholipid membrane component.

[0013] In a typical implementation, when the film-forming agent is composed of trimethylsiloxysilicate, polypropylsilsesquioxane and methyl polytrimethylsiloxane, that is, the hard film-forming agent is trimethylsiloxysilicate, the soft film-forming agent is polypropylsilsesquioxane, and the solvent is methyl polytrimethylsiloxane, the mass ratio of the trimethylsiloxysilicate, polypropylsilsesquioxane, methyl polytrimethylsiloxane, polyquaternium-61 and polyquaternium-65 is preferably 0.1-10: 0.1-10: 1-10: 0.001-1: 0.0001-1, more preferably 2-5: 1-2: 4-7: 0.002: 0.0003, and more preferably 2-5: 1-2: 4-7: 0.002: 0.0003, the most preferred is 2.8:1.2:4:0.002:0.0003.

[0014] The present application has no particular restrictions on the preparation method of the bionic skin biological composition composition. The hard film former, the soft film former and the solvent can be mixed to obtain the film former, the polyquaternium-61, the polyquaternium-6, the stabilizer and the solvent can be mixed to obtain the cell phospholipid membrane component, and then the film former and the cell phospholipid membrane component can be mixed; the hard film former, the soft film former, the solvent used for the film former, the polyquaternium-61, the polyquaternium-6, the stabilizer and the solvent used for the cell phospholipid membrane component can also be directly mixed. It can be understood by those skilled in the art that the solvent used for the film former and the solvent used for the cell phospholipid membrane component can be the same or different.

[0015] The bionic skin biological composition provided by the present application has good anti-migration ability and good strong and tough anti-tearing ability, can significantly improve the cracking of the film layer, show good cosmetic product compliance, and is conducive to makeup. The bionic skin biological composition provided by the present application can enhance the brightness of the makeup, give the skin a natural luster, reduce dullness, and provide a more skin-friendly and comfortable skin feel. Moreover, the bionic skin biological composition provided by the present application does not affect the transdermal absorption of the active ingredients, and compared with the traditional soft and hard film forming agents, it also has the effect of promoting the transdermal absorption of the active ingredients. Therefore, the bionic skin biological composition provided by the present application has good flexibility, can "lock the color powder", has good anti-migration effect, good natural luster and skin-friendly and comfortable skin feel, does not affect the transdermal absorption of the active ingredients of the cosmetics, and can be used in skin care cosmetics, such as base makeup products, lipsticks, lip glazes, and sunscreen products, to help fit and hold the makeup, and realize makeup and maintenance.

[0016] Based on this, the present application also provides a makeup and skin care integrated cosmetic, comprising the bionic skin biological composition described in the above technical solution. In a typical implementation, in the makeup and skin care integrated cosmetic, the content of the bionic skin biological composition is 5wt%~20wt%, preferably 7wt%~15wt%.

[0017] According to the classification principle of cosmetics, cosmetics can be divided into: cleaning cosmetics, care cosmetics and beauty / modification cosmetics. Among them, the cleaning cosmetics refer to cosmetics that are applied to the human body surface (such as epidermis, hair, nails, lips, etc.) by smearing, spraying or other similar methods to play a role in cleaning and hygiene or eliminating bad odors. The care cosmetics refer to cosmetics that are applied to the human body surface (such as epidermis, hair, nails, lips, etc.) by smearing, spraying or other similar methods to play a maintenance role. The beauty / modification cosmetics refer to cosmetics that are applied to the human body surface (such as epidermis, hair, nails, lips, etc.) by smearing, spraying or other similar methods to play a role in beautification, modification, and increasing the charm of the human body. In the present application, the cosmetics are preferably care cosmetics or beauty / modification cosmetics, especially applied to the epidermis and lips.

[0018] Skin care cosmetics include but are not limited to: skin care creams, lotions or toners; skin beauty / decorative cosmetics include but are not limited to pressed powder, liquid foundation, rouge, eye shadow, eyeliner (liquid), eyebrow pencil, perfume or cologne; lip care cosmetics include but are not limited to lip balm; lip beauty / decorative cosmetics include but are not limited to lipstick, lip gloss or lip liner.

[0019] The present application has no particular restrictions on the composition of the cosmetics. For example, when it is a liquid foundation, in addition to the bionic skin biological composition, it may also include at least one of an emulsifier, a thickener, a filler, a moisturizer, a colorant and a soothing agent.

[0020] The present application compounds a film-forming agent including a hard film-forming agent and a soft film-forming agent with a cell phospholipid membrane component including polyquaternium-61 and polyquaternium-65 to obtain a composition of bionic skin biological composition, which has good anti-migration and anti-tear effects, significantly improves the adherence of cosmetic products, and has a good makeup-lasting effect; after film formation, the composition has good flexibility and a comfortable skin feel, can improve whitening, give the skin a natural luster, and does not affect the transdermal absorption of active ingredients in cosmetics, helping to create skin-nourishing cosmetics and achieve makeup-nourishing integration. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a structural comparison diagram of cell phospholipid membrane and human cells;

[0022] Figure 2 It is a color photograph of the film formed in Example 1 and its comparative example;

[0023] Figure 3 The L value changes of the films formed by the compositions provided in the Examples and Comparative Examples;

[0024] Figure 4 This is a photo of the film layer formed by the composition provided in the examples and comparative examples of the present application after being torn;

[0025] Figure 5 This is a diagram showing the transdermal effect of the liquid foundation provided in Example 8;

[0026] Figure 6 This is a diagram showing the transdermal effect of the liquid foundation provided in Comparative Example 8. DETAILED DESCRIPTION

[0027] It should be understood that the expression "one or more of..." includes each of the items recited after the expression individually and in various different combinations of two or more of the recited items, unless otherwise understood from the context and usage. The expression "and / or" in combination with three or more recited items should be understood to have the same meaning, unless otherwise understood from the context.

[0028] The use of the terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, for example not excluding other unrecited elements or steps, unless otherwise specifically stated or otherwise understood from the context.

[0029] It should be understood that the order of steps or the order in which certain actions are performed is not important as long as the present invention remains operable. In addition, two or more steps or actions may be performed simultaneously.

[0030] The use of any and all examples or exemplary language, such as "for example" or "including", herein is intended only to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating that any non-claimed element is essential to the practice of the invention.

[0031] In addition, the numerical ranges and parameters used to define the present invention are approximate values, and the relevant values ​​in the specific embodiments have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. Therefore, unless otherwise expressly stated, it should be understood that all ranges, quantities, values ​​and percentages used in this disclosure are modified by "about". Here, "about" generally means that the actual value is within plus or minus 10%, 5%, 1% or 0.5% of a specific value or range.

[0032] The present application provides a bionic skin biological composition, comprising:

[0033] A film-forming agent, wherein the film-forming agent comprises a hard film-forming agent, a soft film-forming agent and a solvent in a mass ratio of 30-40:10-20:40-60;

[0034] A cell phospholipid membrane component, wherein the cell phospholipid membrane component comprises polyquaternium-61, polyquaternium-65, a stabilizer and a solvent in a mass ratio of 1-3:0.1-0.5:20-30:60-75;

[0035] The mass ratio of the film-forming agent to the cell phospholipid membrane component is 6-15:0.1.

[0036] The present application compounds a film-forming agent including a hard film-forming agent and a soft film-forming agent with a cell phospholipid membrane component including polyquaternium-61 and polyquaternium-65 to obtain a composition of bionic skin biological composition, which has good anti-migration and anti-tear effects, significantly improves the adherence of cosmetic products, and has a good makeup-lasting effect; after film formation, the composition has good flexibility and a comfortable skin feel, can improve whitening, give the skin a natural luster, and does not affect the transdermal absorption of active ingredients in cosmetics, helping to create skin-nourishing cosmetics and achieve makeup-nourishing integration.

[0037] The bionic skin biological composition and its application in cosmetics are further described below with reference to the examples.

[0038] In the following embodiments, the film-forming agent includes: 35 wt % of trimethylsiloxysilicate, 15 wt % of polypropylsilsesquioxane and 50 wt % of methyl polytrimethylsiloxane; the trimethylsiloxysilicate, polypropylsilsesquioxane and methyl polytrimethylsiloxane are mixed and dissolved uniformly.

[0039] The cell phospholipid membrane 1 comprises: 2wt% of polyquaternium-61, 0.3wt% of polyquaternium-65, 3wt% of caprylic / capric glyceride, 25wt% of polyglycerol-3 polydimethylsilyl hydroxyethyl polydimethylsiloxane and 69.7wt% of isononyl isononanoate; the components are mixed and dissolved uniformly.

[0040] The cell phospholipid membrane 2 comprises: 0.3 wt % of polyquaternium-51, 2 wt % of polyquaternium-61, 40 wt % of polyglycerol-3 oleate, 32.7 wt % of triethylhexanoin and 25 wt % of coconut oil alcohol-caprylate / caprate. The components are mixed and dissolved uniformly.

[0041] Examples 1 to 7, Comparative Examples 1-1 to 7-2

[0042] The composition was prepared according to the formula shown in Table 1. The preparation method was as follows:

[0043] Accurately weigh each component and stir to mix evenly.

[0044] Table 1 Composition formula provided in Examples and Comparative Examples

[0045]

[0046] Test Example 1: Adhesion and anti-migration test

[0047] Test method:

[0048] (1) Using an applicator with a thickness of 60 μm, the samples prepared in Examples 1 to 7 and Comparative Examples 1-1 to 7-2 were applied to a glass plate;

[0049] (2) After standing for 15 minutes, use filter paper (2.5*2.5cm) to spread on the top of the glass plate test sample, apply an equal weight on top, remove the filter paper, and compare the weight of the filter paper before and after it touches the test sample. The difference is the weight of the sample that has been migrated. The results are shown in Table 2, which shows the test results of the docile anti-migration ability.

[0050] Table 2 Test results of adhesion and anti-migration ability

[0051]

[0052] When the t-test method is used for statistical analysis, the comparison with the blank group is expressed as P1-value. The comparison with the first comparative example (e.g., comparative example 1-1, comparative example 2-1, etc.) is expressed as P2-value. The comparison with the second comparative example (e.g., comparative example 1-2, comparative example 2-2, etc.) is expressed as P3-value. All significance levels are expressed as *, P-value ≤ 0.05 is expressed as *, P-value ≤ 0.01 is expressed as **, and P-value ≤ 0.001 is expressed as ***.

[0053] From Table 2, we can see that:

[0054] Compared with Comparative Examples 1-1 and 1-2, the composition disclosed in Example 1 has significant differences in migration amount on the basis of the same dosage, indicating that the film-forming agent component and the cell phospholipid membrane 1 component have a synergistic effect in anti-migration.

[0055] It can be seen from Comparative Examples 1-3 and 1-4 that although the cell phospholipid membrane 2 has a better anti-migration ability when used alone, it does not produce a synergistic effect with the film-forming agent component.

[0056] Compared with Comparative Examples 2-1 and 2-2, the composition disclosed in Example 2 has no significant difference in migration amount based on the same dosage, indicating that under the proportion disclosed in Example 2, the film-forming agent component and the cell phospholipid membrane component 1 do not have a synergistic effect.

[0057] Compared with Comparative Examples 3-1 and 3-2, the composition disclosed in Example 3 has no significant difference in migration amount based on the same dosage, indicating that under the proportion disclosed in Example 3, the film-forming agent component and the cell phospholipid membrane component 1 do not have a synergistic effect.

[0058] The composition disclosed in Example 4 has a significant difference in migration amount compared with Comparative Example 4-2 on the basis of the same dosage, indicating that under the ratio disclosed in Example 4, the film-forming agent component and the cell phospholipid membrane component 1 have a synergistic effect.

[0059] The composition disclosed in Example 5 has a significant difference in migration amount compared with that of Comparative Example 5-1 on the basis of the same dosage, indicating that at the ratio disclosed in Example 5, the film-forming agent component and the cell phospholipid membrane component 1 have a synergistic effect.

[0060] Compared with Comparative Examples 6-1 and 6-2, the composition disclosed in Example 6 has significant differences in migration amount on the basis of the same dosage, indicating that the film-forming agent component and the cell phospholipid membrane 1 component have a synergistic effect in anti-migration.

[0061] The composition disclosed in Example 7 has a significant difference in migration amount compared with Comparative Example 7-2 on the basis of the same dosage, indicating that under the ratio disclosed in Example 7, the film-forming agent component and the cell phospholipid membrane component 1 have a synergistic effect.

[0062] It can be seen that the film-forming agent component and the cell phospholipid membrane 1 component have a synergistic effect when the mass ratio is 6-15:0.1, especially 8-10:0.1.

[0063] Test Example 2: Makeup Color Evaluation

[0064] Test method: Weigh 0.1g of the samples prepared in Examples 1 to 7 and Comparative Examples 1-1 to 1-4, and apply them evenly on a 2.5*2.5cm smooth glass plate / leather. Use an applicator to evenly scrape out a 60 micron thick film layer, bake in a 45°C oven, let stand for 15 minutes, and use a 3nh colorimeter to measure the L value change of the film layer. The results are shown in Table 3. Figure 2 and Figure 3 Table 3 shows the changes in L value of the films formed by the compositions provided in the examples and comparative examples. Figure 2 This is a color photograph of the film formed in Example 1 and its comparative example. Figure 3 The L value changes of the films formed by the compositions provided in the Examples and Comparative Examples, Figure 2 In the figure, from left to right are color photographs of films formed from the compositions provided by the blank group, Comparative Example 1-1, Comparative Example 1-2, Example 1, Comparative Example 1-3, and Comparative Example 1-4.

[0065] Table 3 Changes in L value of films formed by the compositions provided in Examples and Comparative Examples

[0066]

[0067] From Table 3, Figure 2 and Figure 3 It can be seen that the composition provided in the examples of the present application can enhance the brightness of makeup and reduce dullness.

[0068] Test Example 3: Test of the toughness and tear resistance of the fabric

[0069] Test method: Weigh 0.1 g of each of the compositions prepared in Example 1, Comparative Examples 1-1 to 1-4 and the blank group, apply them evenly on artificial leather (2.5*2.5 cm area), and place in a 45°C oven for drying. Tear the leather film layer hard for 3 times, and observe the changes in the film layer after tearing.

[0070] The results are shown in Table 4 and Figure 4 Table 4 is a description of the film layer formed by the composition provided in the examples and comparative examples of the present application after being torn off. Figure 4 These are photographs of the film layers formed by the compositions provided in the examples and comparative examples of the present application after being torn off. From left to right, they are photographs of the films formed by the compositions provided by the blank group, comparative example 1-1, comparative example 1-2, example 1, comparative example 1-3, and comparative example 1-4 after being torn off.

[0071] Table 4 Description of the state of the film layer formed by the composition provided in the examples and comparative examples of the present application after being torn

[0072]

[0073] From Table 4 and Figure 4 It can be seen that compared with the blank group, adding a film-forming agent helps to improve the cracking of the membrane layer; adding a small amount of cell phospholipid membrane on the basis of traditional soft and hard membranes can significantly improve the cracking of the membrane layer.

[0074] Test Example 4: Penetration promotion / no influence on penetration assessment test

[0075] According to the formula shown in Table 5, a liquid foundation was prepared as follows:

[0076] (1) Preparation of phase A: Weigh CI 77891, CI 77492, CI 77491, CI 77499 and part of CI 77499, grind into color paste using a three-roll mill, then weigh the remaining components of phase A and mix evenly.

[0077] (2) Preparation of phase B: Weigh all the components of phase B and stir to mix well.

[0078] (3) While stirring, slowly add phase B into phase A and mix evenly.

[0079] (4) Finally, add the C phase components and stir to mix evenly to complete the sample preparation.

[0080] Table 5 Liquid foundation formula

[0081]

[0082] Test method: Raman imaging-transdermal test, using total polyphenols in pomegranate flower extract as the calibration component, to test the transdermal absorption of active ingredients by different film-forming agents.

[0083] The experimental results can be found in Figure 5 , Figure 6 and Table 6, Figure 5 This is a diagram showing the transdermal effect of the foundation liquid provided in Example 8. Figure 6 This is a diagram showing the transdermal effect of the liquid foundation provided in Comparative Example 8. Figure 5 and Figure 6 In the figure, from top to bottom are the stratum corneum, the active epidermis and the dermis; Table 6 is the skin permeability data of the foundation liquid provided in the embodiments and comparative examples.

[0084] Table 6 Skin permeability data of foundation liquid provided in Examples and Comparative Examples

[0085]

[0086] Depend on Figure 5 , Figure 6 As shown in Table 6, the liquid foundation prepared in Example 8 does not affect the penetration of active ingredients, and its penetration effect is better than that of traditional film-forming agents.

[0087] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A bionic skin biological composition, characterized in that: include: A film-forming agent, wherein the film-forming agent comprises a hard film-forming agent, a soft film-forming agent and a solvent in a mass ratio of 30-40:10-20:40-60; A cell phospholipid membrane component, wherein the cell phospholipid membrane component comprises polyquaternium-61, polyquaternium-65, a stabilizer and a solvent in a mass ratio of 1-3:0.1-0.5:20-30:60-75; The mass ratio of the film-forming agent to the cell phospholipid membrane component is 6-15:0.

1.

2. The bionic skin biological composition according to claim 1, characterized in that: The mass ratio of the film-forming agent to the cell phospholipid membrane component is 8-10:0.

1.

3. The bionic skin biological composition according to claim 2, characterized in that: Among the film-forming agents, the hard film-forming agent is selected from one or more of trimethylsiloxysilicate, trifluoropropyl dimethyl / trimethylsiloxysilicate, polyvinyl pyrrolidone and polyvinyl alcohol; The soft film former is selected from one or more of polypropyl silsesquioxane, acrylic acid (ester) / polydimethylsiloxane copolymer, acrylic acid (ester) / polytrimethylsiloxane methacrylate copolymer, VP / hexadecene copolymer, butyl acrylate / hydroxypropyl polydimethylsiloxane acrylate copolymer and polyurethane film former; The solvent is selected from one or more of methyl trimethicone, dimethicone, C13-15 alkane, C12-15 alcohol benzoate, cyclopentasiloxane and caprylic / capric triglyceride.

4. The bionic skin biological composition according to claim 2, characterized in that: In the cell phospholipid membrane component, the stabilizer is selected from one or more of polyglyceryl-3 polydimethylsilyl hydroxyethyl polydimethylsiloxane, polyglyceryl-3 oleate, polyglyceryl-3 diisostearate, diisostearyl polyglyceryl-3 dimer linoleate, polyglyceryl-6 polyricinoleate and glyceryl stearate.

5. The bionic skin biological composition according to claim 4, characterized in that: In the cell phospholipid membrane component, the solvent is selected from one or more of isododecane, squalane, coconut oil alcohol-caprylate / caprate, tri(ethylhexanoin)glyceryl, caprylic / capric glyceride and isononyl isononanoate.

6. The bionic skin biological composition according to any one of claims 1 to 5, characterized in that: Among the film-forming agents, the hard film-forming agent is trimethylsiloxysilicate, the soft film-forming agent is polypropylsilsesquioxane, and when the solvent is methyl polytrimethylsiloxane, the mass ratio of the trimethylsiloxysilicate, polypropylsilsesquioxane, methyl polytrimethylsiloxane, polyquaternium-61 and polyquaternium-65 is 0.1~10:0.1~10:1~10:0.001~1:0.0001~1.

7. The bionic skin biological composition according to claim 6, characterized in that: The mass ratio of the trimethylsiloxysilicate, polypropylsilsesquioxane, methyl polytrimethylsiloxane, polyquaternium-61 and polyquaternium-65 is 2-5: 1-2: 4-7: 0.002: 0.0003.

8. Use of the bionic skin biological composition according to any one of claims 1 to 7 in the preparation of cosmetics.

9. A cosmetic, characterized in that: A bionic skin biological composition comprising the bionic skin biological composition according to any one of claims 1 to 7.

10. The cosmetic according to claim 9, characterized in that: The content of the bionic skin biological composition is 5wt%-20wt%.

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