Plant extract composition with light damage protection effect as well as preparation and application of plant extract composition

Abstract

The invention relates to the field of cosmetics, in particular to a plant extract composition with a light damage protection effect and preparation and application thereof. The plant extract comprises the following components in parts by weight: 1-4 parts of a scutellaria baicalensis root extract, 0.5-1.5 parts of a sophora flower bud extract and 35-50 parts of a cyclodextrin derivative. According to the composition, the scutellaria baicalensis root extract, the sophora flower bud extract and the cyclodextrin derivative are compounded and can achieve a synergistic effect, and the composition has remarkable light damage prevention and anti-sugar effects. The aqueous solution of the plant extract composition has good stability and can be widely applied to the fields of cosmetics and biological medicines.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to a plant extract composition with light damage protection function and a preparation method and application thereof. Background Art

[0002] People are paying more and more attention to the appearance of their skin. Skin aging is divided into endogenous aging and exogenous aging. In the exploration of skin aging, genetic factors, environment, ultraviolet (UV) radiation, etc. can all lead to skin aging. Ultraviolet radiation on the skin can cause the skin to become rough, the complexion to be sallow and dull, and wrinkles to become deeper. At the same time, glycation reaction is also one of the factors of human aging and dark skin. Glycation mainly refers to the effect of sugar on collagen and elastin in the dermis of the skin - glycated collagen and elastin will lose their physiological functions and support and elasticity for skin tissue, causing the skin to show signs of aging, mainly manifested as yellow and dull skin color, acne, enlarged pores and loss of skin elasticity.

[0003] At present, anti-aging is mainly carried out through anti-oxidation, anti-photodamage, anti-glycation and other means. Photodamage can be protected by using sunscreen products. Common anti-glycation ingredients in skin care products are mostly carnosine, bilberry extract, albizzia bark extract, blueberry extract, ascorbic acid, quercetin glucoside, α-tocopherol, niacinamide, etc. Existing anti-aging products have their own advantages and disadvantages. Their functions are relatively single, and some of the raw materials used will cause certain damage to the skin barrier after long-term use. Therefore, there is an urgent need for a safe and comprehensive anti-aging protection product. Summary of the invention

[0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a plant extract composition with light damage protection and anti-sugar effects.

[0005] To achieve the above object, the technical solution adopted by the present invention is:

[0006] In a first aspect, the present invention provides a plant extract comprising the following components in parts by weight: 1-4 parts of scutellaria root extract, 0.5-1.5 parts of sophora japonica bud extract, and 35-50 parts of cyclodextrin derivatives.

[0007] Scutellaria root extract contains flavonoids such as baicalin, which have anti-inflammatory and soothing effects. At the same time, Sophora japonica bud extract contains ingredients such as rutin and isoquercetin, which have anti-inflammatory and whitening effects. The present invention has found through a large number of experimental investigations that by compounding scutellaria root extract, sophora japonica bud extract and cyclodextrin derivatives within a specific range, baicalin, a main component of the scutellaria extract, and other flavonoid components have the effects of scavenging active oxygen, inhibiting the secretion of inflammatory factors IL-6 and TNF-α, and reducing the degradation of human collagen and the synthesis of DNA damage products; the sophora japonica bud extract mainly contains components such as isoquercetin and rutin, which have the effects of scavenging active oxygen, inhibiting the production of COX-2, IL-6, IL-1β and TNF-α, and preventing the expression of AP-1, MMP-1 and MMP-3, thereby preventing the degradation of collagen fibers in the skin and the synthesis of DNA damage products; the two are water-soluble treated by cyclodextrin derivatives, thereby improving the bioavailability of the two, so that they can jointly resist ultraviolet rays through synergistic effects, and at the same time, they have significant anti-photodamage and anti-sugar effects by acting on different action sites.

[0008] In the present invention, the scutellaria root extract and the sophora japonica bud extract are both alcohol extracts, and can be prepared according to methods known in the art, or obtained through commercial channels.

[0009] Preferably, the plant extract comprises the following components in parts by weight: 2-4 parts of Scutellaria baicalensis root extract, 1-1.2 parts of Sophora japonica bud extract, and 48-50 parts of cyclodextrin derivatives.

[0010] More preferably, the plant extract comprises the following components in parts by weight: 2.5 parts of Scutellaria baicalensis root extract, 1.2 parts of Sophora japonica bud extract, and 48 parts of cyclodextrin derivatives.

[0011] Preferably, the cyclodextrin derivative includes at least one of hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

[0012] Preferably, the scutellaria root extract is prepared by the following steps: extracting the dried and crushed scutellaria root in 70% ethanol, filtering the filtrate, and concentrating to remove alcohol; adding water to a solid content of 30%, adjusting the pH to acidic, stirring, standing, and centrifuging to obtain a precipitate; adding hot acetic acid to dissolve the precipitate, filtering to obtain a filtrate, concentrating, adding water to the original volume, stirring for crystallization, and filtering and drying to obtain the scutellaria root extract.

[0013] Preferably, the alcohol extraction is performed 2-3 times.

[0014] Preferably, the added amount of the 70% ethanol is 8-10 times the weight of the Scutellaria baicalensis root raw material.

[0015] Preferably, the extraction time is 1 h.

[0016] Preferably, the pH is adjusted to 1.5-2 using hydrochloric acid.

[0017] Preferably, the amount of hot acetic acid added is 5 times the weight of the precipitate.

[0018] Preferably, the dissolving precipitate is performed at 50° C. for 1 hour.

[0019] Preferably, the stirring crystallization conditions are: stirring crystallization at 4° C. for 24 hours.

[0020] More preferably, the scutellaria root extract is prepared by the following steps:

[0021] The raw material of Scutellaria baicalensis root is dried at high temperature (100°C), sliced, crushed, added with 70% ethanol, stirred and extracted at 50°C for 2-3 times, the amount of 70% ethanol added is 8-10 times the weight of the raw material of Scutellaria baicalensis root, the extraction time is 1h, the extract is filtered to obtain a filtrate, and concentrated until there is no alcohol taste; water is added to the solid content of 30%, the pH is adjusted to 1.5-2 with hydrochloric acid, stirred evenly, allowed to stand for 24h, and centrifuged to obtain a precipitate; 5 times the amount of hot acetic acid (50°C) is added to the precipitate, stirred and dissolved for 1h, filtered while hot to obtain a filtrate, concentrated, watered to the original volume, stirred and crystallized at 4°C for 24h, filtered and dried to obtain the Scutellaria baicalensis root extract.

[0022] Preferably, the Sophora japonica bud extract is prepared by the following steps:

[0023] The dried and crushed Sophora japonica buds are subjected to alcohol extraction in 50% ethanol, and the supernatant is filtered to obtain the supernatant, which is concentrated to remove the alcohol, refrigerated and centrifuged to obtain a precipitate; water is added to dissolve the precipitate, filtered, refrigerated again, and centrifuged to obtain a precipitate; water is added to completely dissolve the precipitate, the pH is adjusted, filtered, concentrated, and dried to obtain the Sophora japonica bud extract.

[0024] Preferably, the added amount of the 50% ethanol is 15-20 times the weight of the Sophora japonica bud raw material.

[0025] Preferably, the alcohol extraction is performed 2-3 times.

[0026] Preferably, the extraction time is 1-2h.

[0027] More preferably, the Sophora japonica bud extract is prepared by the following steps:

[0028] The raw material of Sophora japonica bud is dried at high temperature (100°C), crushed, and extracted 2-3 times by adding 50% ethanol, wherein the amount of 50% ethanol added is 15-20 times the weight of the raw material of Sophora japonica bud, and the extraction time is 1-2h. The extract is filtered to obtain a filtrate, which is concentrated to be alcohol-free, refrigerated for 24h, and centrifuged to obtain a precipitate. The precipitate is dissolved in boiling water, filtered while hot to obtain a filtrate, refrigerated for 12h, and centrifuged to obtain a precipitate. Three times the amount of water is added to completely dissolve the precipitate at 60°C, the pH is adjusted to pH=1-2, the mixture is stirred at the temperature for 2h, filtered, concentrated, and dried to obtain the Sophora japonica bud extract.

[0029] In a second aspect, the present invention provides a method for preparing the above-mentioned plant extract, comprising the following steps:

[0030] (1) weighing a cyclodextrin derivative, adding ethanol with a purity of more than 90% and stirring to dissolve; then adding a scutellaria root extract and a sophora japonica bud extract in sequence and stirring to react to obtain a mixed solution;

[0031] (2) concentrating to remove alcohol, replenishing water, filtering, concentrating, drying, and crushing to obtain the plant extract composition.

[0032] The present invention has found through a large number of experimental studies that using anhydrous ethanol to treat cyclodextrin derivatives is conducive to subsequent effective embedding, while using conventional water treatment cannot effectively embed.

[0033] Preferably, the alcohol is anhydrous ethanol.

[0034] In a third aspect, the present invention provides use of the above-mentioned plant extract in cosmetics.

[0035] In a fourth aspect, the present invention provides a cosmetic comprising the above-mentioned plant extract.

[0036] Preferably, the mass percentage of the plant extract composition in the cosmetic is 0.2%-20%.

[0037] The beneficial effects of the present invention are:

[0038] The present invention obtains a plant extract composition by compounding a scutellaria root extract, a sophora japonica bud extract, and a cyclodextrin derivative, which has significant light damage protection and anti-sugar effects. The plant extract composition has obvious synergistic effects, and the lack of any of the components will lead to a significant decrease in the effect. The aqueous solution of the plant extract composition has good stability and can be widely used in the fields of cosmetics and biomedicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1Appearance diagram of an aqueous solution (left) and an alcohol solution (right) of a 1% plant extract composition; wherein, the storage conditions of the aqueous solution from left to right are: room temperature, high temperature (45°C), pH=5 (45°C), pH=6 (45°C), low temperature (4°C), pH=4, pH=5, pH=6, pH=7, pH=8, pH=9, pH=10; the storage conditions of the alcohol solution from left to right are: room temperature, high temperature (45°C), pH=4, pH=5, pH=6.

[0040] Figure 2 Appearance pictures of an aqueous solution (left) and an alcohol solution (right) of a 1% plant extract composition after being placed under different conditions for one month; the conditions for the aqueous solution from left to right are: room temperature, high temperature (45°C), pH=5 (45°C), pH=6 (45°C), low temperature (4°C), pH=4, pH=5, pH=6, pH=7, pH=8, pH=9, pH=10; the conditions for the alcohol solution from left to right are: room temperature, high temperature (45°C), pH=4, pH=5, pH=6.

[0041] Figure 3 This is an appearance diagram of the plant extract composition of Comparative Example 8 of the present invention.

[0042] Figure 4 This is the photodamage protection result of the plant extract composition of Example 2 of the present invention. DETAILED DESCRIPTION

[0043] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0044] Unless otherwise specified, the materials used in the present invention can be purchased from commercial sources.

[0045] Embodiment 1-5:

[0046] Examples 1-5 are examples of the plant extract composition of the present invention; the components and their proportions of the plant extract composition of each example are shown in Table 1.

[0047] Table 1

[0048]

[0049] The scutellaria root extract is prepared by the following steps:

[0050] The raw material of Scutellaria baicalensis root is dried at high temperature (100°C), sliced, crushed, added with 70% ethanol and stirred at 50°C for extraction 3 times, the amount of 70% ethanol added is 8 times the weight of the raw material of Scutellaria baicalensis root, the extraction time is 1 hour, the extract is filtered to obtain a filtrate, and concentrated until there is no alcohol taste; water is added to the solid content of 30%, the pH is adjusted to 2 with hydrochloric acid, stirred evenly, allowed to stand for 24 hours, and centrifuged to obtain a precipitate; 5 times the amount of hot acetic acid (50°C) is added to the precipitate, stirred and dissolved for 1 hour, filtered while hot to obtain a filtrate, concentrated, watered to the original volume, stirred and crystallized at 4°C for 24 hours, filtered and dried to obtain the Scutellaria baicalensis root extract.

[0051] The Sophora japonica bud extract is prepared by the following steps:

[0052] The Sophora japonica bud raw material is dried at high temperature (100°C), crushed, and extracted three times with 50% ethanol, wherein the amount of 50% ethanol added is 15 times the weight of the Sophora japonica bud raw material, and the extraction time is 1 hour. The extract is filtered to obtain a filtrate, which is concentrated to be alcohol-free, refrigerated for 24 hours, and centrifuged to obtain a precipitate. The precipitate is dissolved in boiling water, filtered while hot to obtain a filtrate, refrigerated for 12 hours, and centrifuged to obtain a precipitate. Three times the amount of water is added to completely dissolve it at 60°C, the pH is adjusted to pH=1-2, the mixture is kept warm and stirred for 2 hours, filtered, concentrated, and dried to obtain the Sophora japonica bud extract.

[0053] The preparation method of the plant extract composition comprises the following steps:

[0054] Weigh hydroxypropyl-β-cyclodextrin / hydroxypropyl-γ-cyclodextrin, add 150 parts of 95% ethanol, stir and dissolve at 60°C for 1 hour; add scutellaria root extract, stir and react at 60°C for 2 hours; then add sophora japonica bud extract, stir and react at 60°C for 2 hours; concentrate to remove alcohol, add water to the original volume, filter with medium-speed filter paper, take the filtrate and filter with a 1.2-micron microporous filter membrane, concentrate at 70°C to a solid content of more than 65%, vacuum dry, and grind through an 80-mesh sieve to obtain the plant extract composition.

[0055] Embodiment 6:

[0056] An embodiment of the plant extract composition of the present invention; the difference between this embodiment and embodiment 2 is that the preparation of the scutellaria root extract is different from that of embodiment 2; the scutellaria root extract is prepared by the following steps:

[0057] The raw material of Scutellaria baicalensis root is dried at high temperature (100°C), sliced, crushed, added with 70% ethanol and stirred and extracted twice at 50°C, the amount of 70% ethanol added is 10 times the weight of the raw material of Scutellaria baicalensis root, the extraction time is 1h, the extract is filtered to obtain a filtrate, and concentrated until there is no alcohol taste; water is added to the solid content of 30%, the pH is adjusted to 1.5 with hydrochloric acid, stirred evenly, allowed to stand for 24h, and centrifuged to obtain a precipitate; 5 times the amount of hot acetic acid (50°C) is added to the precipitate, stirred and dissolved for 1h, filtered while hot to obtain a filtrate, concentrated, watered to the original volume, stirred and crystallized at 4°C for 24h, filtered and dried to obtain the Scutellaria baicalensis root extract.

[0058] Embodiment 7:

[0059] An embodiment of the plant extract composition of the present invention; the difference between this embodiment and embodiment 2 is that the preparation of the scutellaria root extract is different from that of embodiment 2; the sophora japonica bud extract is prepared by the following steps:

[0060] The Sophora japonica bud raw material is dried at high temperature (100°C), crushed, and extracted twice with 50% ethanol, wherein the amount of 50% ethanol added is 20 times the weight of the Sophora japonica bud raw material, and the extraction time is 2 hours. The extract is filtered to obtain a filtrate, which is concentrated to be alcohol-free, refrigerated for 24 hours, and centrifuged to obtain a precipitate. The precipitate is dissolved in boiling water, filtered while hot to obtain a filtrate, refrigerated for 12 hours, and centrifuged to obtain a precipitate. Three times the amount of water is added to completely dissolve it at 60°C, the pH is adjusted to pH=1-2, the mixture is stirred at this temperature for 2 hours, filtered, concentrated, and dried to obtain the Sophora japonica bud extract.

[0061] Comparative Examples 1-7:

[0062] Comparative Examples 1-7 are comparative examples of the plant extract composition of the present invention; the components and proportions of the plant extract composition of each comparative example are shown in Table 2.

[0063] Table 2

[0064]

[0065] Among them, the only difference between Comparative Examples 1-3 and Example 2 is that: Comparative Example 1 does not add Scutellaria baicalensis root extract; Comparative Example 2 does not add Scutellaria baicalensis root extract; Comparative Example 3 does not add hydroxypropyl-β-cyclodextrin; the missing components are replaced by equal weight parts of water.

[0066] The difference between Comparative Example 4 and Example 2 is that the scutellaria root extract is replaced with an equal weight portion of purslane extract. The difference between Comparative Example 5 and Example 2 is that the scutellaria root extract is obtained by water extraction.

[0067] The preparation methods of the plant extract compositions described in Comparative Examples 1-7 are the same as those in Example 2.

[0068] Comparative Example 8:

[0069] Comparative Example 8 is a comparative example of the plant extract composition of the present invention; the difference between this comparative example and Example 2 is only that the preparation method of the plant extract composition is different, and the rest is the same as Example 2.

[0070] The preparation method of the plant extract composition described in this comparative example comprises the following steps:

[0071] Weigh hydroxypropyl-β-cyclodextrin, add 150 parts of water, stir and dissolve at 60°C for 1 hour; add scutellaria root extract, stir and react at 60°C for 2 hours; then add sophora japonica bud extract, stir and react at 60°C for 2 hours; concentrate, add water to the original volume, filter with medium-speed filter paper, take the filtrate and filter with a 1.2-micron microporous filter membrane, concentrate at 70°C to a solid content of more than 65%, vacuum dry, and grind through an 80-mesh sieve to obtain the plant extract composition.

[0072] Test Example 1: Stability Test

[0073] Test sample: the plant extract composition prepared in Example 2.

[0074] The plant extract composition was dissolved in deionized water to a solution concentration of 1% ( Figure 1 ) to make the solution clear and transparent, and then place it under normal temperature, high temperature (45°C), pH = 5-6 (45°C), low temperature (4°C), pH = 4-10 (normal temperature) conditions for 3 months to test the stability of the aqueous solution of the plant extract composition.

[0075] In addition, the plant extract composition was dissolved in 5% butanediol until the concentration of the plant extract composition in the solution was 1%, and the solution was placed at room temperature, high temperature (45°C), and pH = 4-6 for 3 months to test the stability of the alcohol solution of the plant extract composition.

[0076] After three months, the stability of the plant extract composition was as follows: Figure 2 The aqueous solution of the plant extract composition was placed under different conditions, and the color did not change significantly, and no precipitation was produced. By detecting and analyzing its content, the content of the active ingredient was not significantly reduced, indicating that the aqueous solution of the plant extract composition has good stability and can be widely used.

[0077] In addition, the present invention found that in the preparation of the plant extract composition of comparative example 8, after the reaction was completed, the solution was turbid as a whole. Through the analysis of its effective components, its effective component embedding rate was only one-third of the plant extract composition prepared in Example 2, which caused great waste. At the same time, the effective component content of the product was seriously reduced, and the synergistic effect was greatly reduced. The appearance of the feed liquid after the reaction is as follows Figure 3 shown.

[0078] Test Example 2: Zebrafish embryo tail shrinkage inhibition test

[0079] Test samples: plant extract compositions prepared in Examples 1-7 and Comparative Examples 1-7; the test substances were directly dissolved in fish embryo culture medium to prepare sample solutions with test concentrations of 0.1% and 0.05%, respectively.

[0080] The present invention determines the photodamage protection efficacy through a zebrafish embryo tail wrinkle inhibition test experiment. The zebrafish fins are composed of epidermal-related cells, keratinous fin rays (support structures composed of collagen), and mesenchymal cells. After UVB irradiation, the keratinous fin rays of the zebrafish fins are damaged, and the microscopic manifestation is that the radially ordered fin rays break and become disordered, and the epidermal and mesenchymal cells die. The macroscopic manifestation is that the tail fin loses support and severely wrinkles, which can simulate the damage of the skin after exposure to light. The application of this model can be used to test and screen raw materials and formula products that can prevent photodamage, as well as to evaluate the photodamage protection efficacy of samples.

[0081] Test method: Apply 0.3J / cm 2 The UVB irradiation model was tested. Thirty three-day-old zebrafish embryos were exposed to sample solutions with a test concentration of 0.1% and 0.05%, respectively. A model control group and a blank control group were set up at the same time. After exposure for 1 hour, 0.3 J / cm 2 UVB irradiation was used to establish the model, and then the corresponding solution was replaced. After 24 hours of culture, the fish embryos were photographed under a microscope to measure the tail area and perform statistical analysis. The inhibition rate was obtained by calculating the change in the shrinkage area of ​​the zebrafish embryo tail before and after.

[0082] Test group processing:

[0083] Blank control group: fish embryo culture medium;

[0084] Model control group: fish embryo culture medium + UVB irradiation;

[0085] Positive control group: 5g / L ergothioneine solution + UVB irradiation;

[0086] Sample treatment group: sample solution + UVB irradiation.

[0087] Table 3

[0088]

[0089]

[0090] The results are shown in Table 3. Figure 4As shown, the plant extract composition prepared in the embodiment of the present invention can inhibit the shrinkage of the tail area of ​​zebrafish embryos at a test concentration of 0.1% and a test concentration of 0.05%. Therefore, the plant extract composition prepared in the present invention can significantly reduce the shrinkage of the tail of zebrafish embryos caused by UVB irradiation at a test concentration of 0.1% and a test concentration of 0.05%, and has an effect of preventing light damage.

[0091] In addition, the present invention has found through human anti-glycosylation experimental tests that the plant extract composition prepared in Example 2 of the present invention has obvious anti-glycosylation efficacy, and the inhibition rate of the sample on AGEs can reach more than 10% at a concentration of 1.5%.

[0092] Test Example 3: UV blocking test

[0093] The plant extract composition of Example 2 was prepared into sample solutions with test concentrations of 0.5% and 1.0%, respectively. The blocking rate of the sample in the full band of ultraviolet rays (290nm to 400nm) was tested by SPF-290AS instrument. Reference standard: "Cosmetic Safety Technical Specifications" Chapter 4 Physical and Chemical Testing Methods 1.9 Instrumental Determination of Cosmetic Anti-UVA Ability.

[0094] The barrier rate (%) is calculated according to the following formula:

[0095] Blockage rate (%) = 1-transmittance (%)

[0096] The results show that the plant extract composition prepared by the present invention has an obvious effect of blocking ultraviolet rays. When the concentration of the sample is 0.5%, the UVA blocking rate can reach 22.52%, and the UVB blocking rate can reach 28.85%; when the concentration is 1.0%, the UVA blocking rate can reach 23.92%, and the UVB blocking rate can reach 30.65%.

[0097] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A plant extract composition, characterized in that: The invention comprises the following components in parts by weight: 1-4 parts of scutellaria root extract, 0.5-1.5 parts of sophora japonica bud extract and 35-50 parts of cyclodextrin derivative.

2. The plant extract composition according to claim 1, characterized in that The invention comprises the following components in parts by weight: 2-4 parts of scutellaria root extract, 1-1.2 parts of sophora japonica bud extract and 48-50 parts of cyclodextrin derivative.

3. The plant extract composition according to claim 2, characterized in that The invention comprises the following components in parts by weight: 2.5 parts of scutellaria root extract, 1.2 parts of sophora japonica bud extract and 48 parts of cyclodextrin derivative.

4. The plant extract composition according to claim 1, characterized in that The cyclodextrin derivative includes at least one of hydroxypropyl-β-cyclodextrin and hydroxypropyl-γ-cyclodextrin.

5. The plant extract composition according to claim 1, characterized in that The scutellaria root extract is prepared by the following steps: extracting the dried and crushed scutellaria root in 70% ethanol, filtering the filtrate, concentrating to remove alcohol, adding water to a solid content of 30%, adjusting the pH to acidic, stirring, standing, and centrifuging to obtain a precipitate; Hot acetic acid is added to dissolve the precipitate, and the filtrate is filtered to obtain the filtrate, which is concentrated and then supplemented with water to the original volume, stirred to crystallize, and filtered and dried to obtain the scutellaria root extract.

6. The plant extract composition according to claim 1, characterized in that The sophora japonica bud extract is prepared by the following steps: extracting the dried and crushed sophora japonica buds in 50% ethanol, filtering to obtain a supernatant, concentrating to remove the alcohol, refrigerating and centrifuging to obtain a precipitate; adding water to dissolve the precipitate, filtering, refrigerating and centrifuging again to obtain a precipitate; adding water to completely dissolve the precipitate, adjusting the pH, filtering and concentrating, and drying to obtain the sophora japonica bud extract.

7. A method for preparing the plant extract composition according to any one of claims 1 to 6, characterized in that: The steps include: (1) weighing a cyclodextrin derivative, adding ethanol with a purity of more than 90% and stirring to dissolve; then adding a scutellaria root extract and a sophora japonica bud extract in sequence and stirring to react to obtain a mixed solution; (2) concentrating to remove alcohol, replenishing water, filtering, concentrating, drying, and crushing to obtain the plant extract composition.

8. Use of the plant extract composition according to any one of claims 1 to 6 in cosmetics.

9. A cosmetic, characterized in that: The invention comprises the plant extract composition as claimed in any one of claims 1 to 6.

10. The cosmetic according to claim 9, characterized in that The mass percentage of the plant extract composition in the cosmetics is 0.2%-20%.

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