An antidandruff shampoo containing selenium disulfide and its preparation method

Abstract

The present invention provides an anti-dandruff shampoo containing selenium disulfide and a preparation method thereof, which relates to the field of hair washing products. The anti-dandruff shampoo contains the following components by mass fraction: 0.05 parts - 2.0 parts of selenium disulfide, 10 parts - 40 parts of surfactant, 0.05 parts - 5 parts of plant composition 1, 0.05 parts - 5 parts of plant composition 2, 0.05 parts - 5 parts of plant composition 3, 0.05 parts - 1 part of preservative, and 30 parts - 80 parts of water; the plant composition 1 contains bacillus fermentation product and extract of leaves or stems of Memecylon ligustrifolium Wall.; the plant composition 2 contains asiatic pennywort extract; the plant composition 3 contains extract of Ceratonia siliqua fruit, hydrolyzed lupine protein and jasminum officinale extract. By compounding selenium disulfide with plant compositions 1 - 3, the present invention realizes the functions of effectively removing dandruff while soothing, moisturizing and relieving itching, and solves the technical defects of using selenium disulfide as an anti-dandruff ingredient.

Description

Technical Field

[0001] The present invention relates to the technical field of hair care products, and particularly relates to an anti-dandruff shampoo containing selenium disulfide and a preparation method thereof. Background Art

[0002] Dandruff is a phenomenon of excessive shedding of scalp keratinocytes, which affects the lives of many people. Most researchers believe that dandruff belongs to mild seborrheic dermatitis occurring on the scalp, manifested as the shedding of clumps of dead skin cells from the scalp. The obvious presence of dandruff may cause social embarrassment to individuals. Long-term dandruff problems may have a negative impact on the psychology of individuals. In addition to affecting appearance, dandruff may also be accompanied by discomfort symptoms such as scalp itching, tingling or tightness. These symptoms may affect the sleep quality and daily life quality of individuals.

[0003] Currently, it is generally recognized that the generation mechanism of seborrheic dermatitis is the uninhibited proliferation of yeasts of the genus Malassezia. After Malassezia infects the scalp, it may cause abnormal differentiation of keratinocytes, production of pro-inflammatory cytokines, and damage to the skin barrier through a series of mechanisms, thereby leading to an increase in dandruff. Under the action of lipase, Malassezia degrades triglycerides in fat into free fatty acids, and free fatty acids further stimulate the skin to produce an inflammatory reaction, which can also cause the appearance of dandruff. In terms of treatment, it is mainly symptomatic treatment such as degreasing, anti-inflammatory, bactericidal, and antipruritic. Commonly used topical treatment drugs are bifonazole, ciclopirox, ketoconazole, selenium disulfide, zinc pyrithione, tar shampoo, terbinafine, and topical glucocorticoids.

[0004] Selenium disulfide has pharmacological effects of anti-sebaceous gland hyperfunction, inhibiting the reproduction of Malassezia, and anti-epidermal hyperplasia, and has good curative effects on dandruff removal and scalp seborrheic dermatitis. However, selenium disulfide lotion has technical defects such as strong irritation, easy dryness of hair after use, and difficulty in combing. There are already records in the prior art about preparing shampoo with selenium disulfide.

[0005] Chinese Patent CN113648266A discloses a shampoo with the hair nourishing function based on selenium disulfide, which is composed of the following raw materials: traditional Chinese medicine extract, polyporus umbellatus extract, Chinese honey locust extract, plant ash, trimethylammonium chloride chitosan, pimaricin, plant essential oil, selenium disulfide, surfactant, and rice washing water. The traditional Chinese medicine extract is composed of the following raw materials: vitex trifolia, aconite root, mulberry leaf, chuanxiong rhizome, polygonum multiflorum, biota orientalis leaf, gastrodia elata, and walnut shell. In this invention, the traditional Chinese medicine extract and plant composition are used as the main components, with small irritation, no toxic and side effects, rich in vitamins, proteins, and trace elements. At the same time, the plant composition can regulate sebum secretion and reduce dandruff, and will not cause harm to hair and scalp after long-term use. However, the shampoo prepared by this invention focuses on hair care, and the anti-dandruff effect and antibacterial effect are not ideal enough.

[0006] Chinese Patent CN116019739A discloses an anti-dandruff agent, a preparation method thereof, and a daily chemical product. The anti-dandruff agent is water-soluble cyclodextrin; the hydrophobic inner cavity of the water-soluble cyclodextrin is loaded with selenium disulfide; the surface of the water-soluble cyclodextrin is grafted with quaternary ammonium salt; the content of the anti-dandruff agent in the daily chemical product is 0.5-2%; the daily chemical product is one or more of shampoo, hair conditioner, hair shampoo paste, hair conditioner, dry shampoo gel, and dry shampoo spray. However, this product focuses on anti-dandruff and does not consider the technical defects of selenium disulfide lotion, such as high irritation and dryness and itching of the scalp.

[0007] Based on this, developing a shampoo with both anti-dandruff and soothing effects to solve the defects of selenium disulfide lotion, such as high irritation and easy dryness and itching of the scalp after use, is the research focus of researchers in this field. Summary of the Invention

[0008] In view of the above problems, the present invention provides an anti-dandruff shampoo containing selenium disulfide, which has both anti-dandruff and soothing and moisturizing effects through the compounding of selenium disulfide and a plant composition.

[0009] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0010] On the one hand, the present invention provides an anti-dandruff shampoo containing selenium disulfide, which contains the following components by mass:

[0011] 0.05 parts - 2.0 parts of selenium disulfide, 10 parts - 40 parts of surfactant, 0.05 parts - 5 parts of plant composition 1, 0.05 parts - 5 parts of plant composition 2, 0.05 parts - 5 parts of plant composition 3, 0.05 parts - 1 part of preservative, and 30 parts - 80 parts of water;

[0012] The plant composition 1 contains Bacillus fermentation product and Morus rotundata leaf or stem extract;

[0013] The plant composition 2 contains Centella asiatica extract;

[0014] The plant composition 3 contains Ceratonia siliqua fruit extract, hydrolyzed lupine protein, and Jasminum officinale extract.

[0015] Preferably, it contains the following components by mass:

[0016] 0.5 parts - 1.5 parts of selenium disulfide, 15 parts - 30 parts of surfactant, 1 part - 4 parts of plant composition 1, 1 part - 4 parts of plant composition 2, 1 part - 4 parts of plant composition 3, 0.1 parts - 0.8 parts of preservative, and 50 parts - 70 parts of water.

[0017] Further preferably, it contains the following components by mass:

[0018] 0.8 - 1 part of selenium disulfide, 20 - 30 parts of surfactant, 1 - 3 parts of plant composition 1, 1 - 3 parts of plant composition 2, 1 - 3 parts of plant composition 3, 0.1 - 0.5 part of preservative, and 60 - 70 parts of water.

[0019] Preferably, the water is selected from at least one of deionized water, ultrapure water, and pure water; more preferably, the water is deionized water.

[0020] Preferably, the plant composition 1 is a mixture of bacillus fermentation product, extract of leaves or stems of Memecylon ligustrifolium Champ., p - hydroxyacetophenone, and 1,2 - pentanediol;

[0021] Preferably, the mass ratio of the bacillus fermentation product, extract of leaves or stems of Memecylon ligustrifolium Champ., p - hydroxyacetophenone, and 1,2 - pentanediol is 0.8 - 1.2:0.1 - 0.5:0.1 - 0.5:0.05 - 0.2.

[0022] More preferably, the mass ratio of the bacillus fermentation product, extract of leaves or stems of Memecylon ligustrifolium Champ., p - hydroxyacetophenone, and 1,2 - pentanediol is 1:0.3:0.3:0.1.

[0023] Preferably, the plant composition 2 is a mixture of centella asiatica extract and propylene glycol;

[0024] Preferably, the mass ratio of the centella asiatica extract and propylene glycol is 1:5 - 10;

[0025] More preferably, the mass ratio of the centella asiatica extract and propylene glycol is 1:9;

[0026] Preferably, the plant composition 3 is a mixture of ceratonia siliqua fruit extract, hydrolyzed lupine protein, jasminum officinale extract, ethylhexylglycerin, 1,2 - hexanediol, glycerol, and water;

[0027] Preferably, the mass ratio of the ceratonia siliqua fruit extract, hydrolyzed lupine protein, jasminum officinale extract, ethylhexylglycerin, 1,2 - hexanediol, glycerol, and water is 0.8 - 1.2:0.5 - 1.2:0.05 - 0.2:0.5 - 1.5:20 - 30:15 - 25.

[0028] More preferably, the mass ratio of the ceratonia siliqua fruit extract, hydrolyzed lupine protein, jasminum officinale extract, ethylhexylglycerin, 1,2 - hexanediol, glycerol, and water is 1:0.9:1:0.1:1:25:21.

[0029] Preferably, the mass ratio of the plant composition 1, the plant composition 2, and the plant composition 3 is 0.1-4:0.1-4:0.1-4; more preferably, the mass ratio of the plant composition 1, the plant composition 2, and the plant composition 3 is 1-3:1-3:1-3.

[0030] Preferably, the surfactant is selected from at least two of sodium lauryl polyether sulfate, ammonium lauryl sulfate, cocoamidopropyl betaine, sodium methyl cocoyl taurate, disodium cocoyl glutamate, and sodium lauroyl sarcosine.

[0031] More preferably, the surfactant is sodium lauryl polyether sulfate, ammonium lauryl sulfate, and cocoamidopropyl betaine.

[0032] Preferably, the mass ratio of sodium lauryl polyether sulfate, ammonium lauryl sulfate, and cocoamidopropyl betaine as the surfactant is 10-15:1-6:2-5.

[0033] More preferably, the mass ratio of sodium lauryl polyether sulfate, ammonium lauryl sulfate, and cocoamidopropyl betaine as the surfactant is 10-12:1-3:3-5.

[0034] Preferably, the preservative is selected from at least one of phenoxyethanol, potassium sorbate, Kathon, iodopropynyl butylcarbamate, ethylhexylglycerin, glyceryl laurate, glyceryl caprylate, sodium benzoate, benzyl alcohol, and sodium salicylate.

[0035] In addition, the selenium disulfide shampoo of the present invention may further contain at least one of the following components:

[0036] (1) Hair conditioner: such as at least one of guar gum hydroxypropyltrimethyl ammonium chloride, polyquaternium-7, polyquaternium-10, polyquaternium-67, polyquaternium-47, polyquaternium-22, stearamidopropyl dimethylamine, glycerol, salicylic acid, menthol, and emulsifying silicone oil;

[0037] (2) Suspending agent: such as at least one of acrylate copolymer, acrylate / C10-30 alkanol acrylate cross-linked polymer, bentonite, microcrystalline cellulose, distearyl phthalic amide, hydroxypropyl starch phosphate, and hydrogenated castor oil;

[0038] (3) pH regulator: such as at least one of citric acid, lactic acid, sodium hydroxide, sodium citrate, and arginine;

[0039] (4) Chelating agent: such as at least one of disodium EDTA, sodium dihydrogen phosphate, HEPES buffer, and disodium hydrogen phosphate;

[0040] (5) Flavor and pigment.

[0041] Preferably, the anti-dandruff shampoo containing selenium disulfide, by mass parts, comprises the following components:

[0042] 0.05 parts - 2.0 parts of selenium disulfide, 10 parts - 40 parts of surfactant, 0.05 parts - 5 parts of plant composition 1, 0.05 parts - 5 parts of plant composition 2, 0.05 parts - 5 parts of plant composition 3, 0.1 parts - 0.5 parts of hair conditioner, 1 part - 4 parts of suspending agent, 0.1 parts - 0.3 parts of pH regulator, 0.05 parts - 0.15 parts of chelating agent, 0.1 parts - 1 part of essence, 0.05 parts - 1 part of preservative and 30 parts - 80 parts of water;

[0043] On the other hand, the present invention provides a preparation method of the above-mentioned anti-dandruff shampoo containing selenium disulfide, comprising the following steps:

[0044] Step 1: Mix water and surfactant, heat up to 83 - 85 °C, and keep warm for 30 minutes to obtain mixture 1.

[0045] Step 2: Stir and cool mixture 1 to below 40 °C, add selenium disulfide, plant composition 1, plant composition 2, plant composition 3, and preservative, and stir evenly to obtain the anti-dandruff shampoo containing selenium disulfide.

[0046] Preferably, the preparation method comprises the following steps:

[0047] S1: Mix water, chelating agent, hair conditioner, and suspending agent, heat up to 80 - 85 °C, and keep warm for 20 - 40 minutes to obtain mixture 1;

[0048] S2: Cool mixture 1 to below 40 °C, add selenium disulfide and mix to obtain mixture 2;

[0049] S3: Mix mixture 2 with plant composition 1, plant composition 2, plant composition 3, pH regulator, essence, and pigment, and stir evenly to obtain the anti-dandruff shampoo containing selenium disulfide.

[0050] Compared with the prior art, the present invention has the following beneficial effects:

[0051] By compounding selenium disulfide with plant composition 1, plant composition 2, and plant composition 3, through specific components and specific ratios, the present invention realizes the function of soothing and moisturizing on the basis of effective anti-dandruff, and solves the technical defects of using selenium disulfide as an anti-dandruff ingredient. Detailed implementation mode

[0052] In order to make the technical means, creative features, achieved purposes and effects of the present invention easy to understand, the present invention will be further illustrated below in conjunction with specific embodiments. However, the following embodiments are only the preferred embodiments of the present invention, not all of them. Based on the embodiments in the implementation manners, other embodiments obtained by those skilled in the art without creative efforts all fall within the protection scope of the present invention. It is worth noting that the raw materials used in the present invention are all ordinary commercially available products, and no specific limitation is made on their sources. The technical and scientific terms used in the embodiments have the same meanings as those generally understood by those of ordinary skill in the technical field to which the present invention belongs.

[0053] Purchase information of some raw materials used in the present invention:

[0054] Sodium lauryl polyether sulfate was purchased from BASF (China) Co., Ltd., model Texapon® N 70;

[0055] Ammonium lauryl sulfate was purchased from BASF (China) Co., Ltd., model Texapon® ALS 1470;

[0056] Cocamidopropyl betaine was purchased from Guangzhou Xingye Technology Co., Ltd., model Ucefactant BE-35F;

[0057] Plant composition 1 was purchased from Guangdong Xuanjia Medical & Health Technology Co., Ltd., model SHINE+ resurrection grass fermentation liquid;

[0058] Plant composition 2 was purchased from Beijing Sanyou Huizhi Biotechnology Co., Ltd., model SH-525;

[0059] Plant composition 3 was purchased from Guizhou Keyichuang Biotechnology Co., Ltd., model Soothing Essence YD.

[0060] Example 1

[0061] This example provides an anti-dandruff shampoo containing selenium disulfide, including the following components:

[0062] Selenium disulfide;

[0063] Surfactant: a mixture of sodium lauryl polyether sulfate, ammonium lauryl sulfate and cocamidopropyl betaine, and the mass ratio of the three is 12:3:5;

[0064] Plant composition 1: a mixture of bacillus fermentation product, Morus rotundata leaf or stem extract, p-hydroxyacetophenone and 1,2-pentanediol, and the mass ratio is 1:0.3:0.3:0.1;

[0065] Plant composition 2: a mixture of centella asiatica extract and propylene glycol, and the mass ratio is 1:9;

[0066] Plant composition 3: A mixture of carob fruit extract, hydrolyzed lupine protein, Jasminum officinale extract, ethylhexylglycerin, 1,2 - hexanediol, glycerol and water, with a mass ratio of 1:0.9:1:0.1:1:25:21;

[0067] Fragrance;

[0068] Preservative: Phenoxyethanol;

[0069] Hair conditioner: Guar hydroxypropyltrimonium chloride;

[0070] Chelating agent: Disodium EDTA;

[0071] pH regulator: Citric acid;

[0072] Suspending agent: Microcrystalline cellulose;

[0073] Deionized water.

[0074] The above components are in parts by mass, specifically:

[0075] Selenium disulfide 1.0 part;

[0076] Surfactant: 20 parts;

[0077] Plant composition 1: 3 parts;

[0078] Plant composition 2: 2 parts;

[0079] Plant composition 3: 1 part;

[0080] Fragrance: 0.5 part;

[0081] Preservative: 0.5 part;

[0082] Hair conditioner: 0.4 part;

[0083] Chelating agent: 0.1 part;

[0084] pH regulator: 0.2 part;

[0085] Suspending agent: 3 parts;

[0086] Deionized water 68.3 parts.

[0087] The described anti - dandruff shampoo containing selenium disulfide has the following specific preparation steps:

[0088] S1: Add disodium EDTA, guar hydroxypropyltrimonium chloride, microcrystalline cellulose and deionized water into a stirring pot and stir evenly.

[0089] S2: Add sodium lauryl polyether sulfate, ammonium lauryl sulfate, cocamidopropyl betaine into the stirring pot, heat to 83 - 85 °C and stir until dissolved evenly.

[0090] S3: Cool down to below 40°C, add selenium disulfide and mix, stir to mix evenly.

[0091] S4: Add Plant Composition 1, Plant Composition 2, Plant Composition 3, essence, citric acid, and preservative into a pot, stir evenly, and then discharge to obtain the described anti-dandruff shampoo containing selenium disulfide.

[0092] Example 2

[0093] Compared with Example 1, only the amounts of each plant composition are changed, and other components are the same as those in Example 1. Specifically:

[0094] Plant Composition 1: 2 parts;

[0095] Plant Composition 2: 2 parts;

[0096] Plant Composition 3: 2 parts;

[0097] The specific preparation steps of the described anti-dandruff shampoo containing selenium disulfide are the same as those in Example 1.

[0098] Example 3

[0099] Compared with Example 1, only the amounts of each plant composition are changed, and other components are the same as those in Example 1. Specifically:

[0100] Plant Composition 1: 1 part;

[0101] Plant Composition 2: 3 parts;

[0102] Plant Composition 3: 2 parts;

[0103] The specific preparation steps of the described anti-dandruff shampoo containing selenium disulfide are the same as those in Example 1.

[0104] Example 4

[0105] Compared with Example 1, only the amounts of each plant composition are changed, and other components are the same as those in Example 1. Specifically:

[0106] Plant Composition 1: 1 part;

[0107] Plant Composition 2: 2 parts;

[0108] Plant Composition 3: 3 parts;

[0109] The specific preparation steps of the described anti-dandruff shampoo containing selenium disulfide are the same as those in Example 1.

[0110] Example 5

[0111] Compared with Example 1, only the amounts of each plant composition are changed, and other components are the same as those in Example 1.

[0112] Plant composition 1: 2 parts;

[0113] Plant composition 2: 1 part;

[0114] Plant composition 3: 3 parts;

[0115] The specific preparation steps of the anti-dandruff shampoo containing selenium disulfide are the same as those in Example 1.

[0116] Example 6

[0117] Compared with Example 1, only the amounts of each plant composition are changed, and other components are the same as those in Example 1. Specifically:

[0118] Plant composition 1: 3 parts;

[0119] Plant composition 2: 1 part;

[0120] Plant composition 3: 2 parts;

[0121] The specific preparation steps of the anti-dandruff shampoo containing selenium disulfide are the same as those in Example 1.

[0122] Comparative Example 1

[0123] Compared with Example 2, plant composition 1 is removed, the amount of plant composition 2 is increased to 3 parts, and the amount of plant composition 3 is increased to 3 parts. Others are the same as those in Example 2.

[0124] Comparative Example 2

[0125] Compared with Example 2, plant composition 2 is removed, the amount of plant composition 1 is increased to 3 parts, and the amount of plant composition 3 is increased to 3 parts. Others are the same as those in Example 2.

[0126] Comparative Example 3

[0127] Compared with Example 2, plant composition 3 is removed, the amount of plant composition 1 is changed to 3 parts, and the amount of plant composition 2 is changed to 3 parts. Others are the same as those in Example 2.

[0128] Comparative Example 4

[0129] Compared with Example 2, plant composition 1 is removed, and the amount of plant composition 2 is increased to 4 parts. Others are the same as those in Example 2.

[0130] Comparative Example 5

[0131] Compared with Example 2, plant composition 2 is removed, and the amount of plant composition 1 is increased to 4 parts. Others are the same as those in Example 2.

[0132] Comparative Example 6

[0133] Compared with Example 2, Plant Composition 3 was removed, and Plant Composition 1 was increased to 4 parts, and the others were the same as Example 2.

[0134] Comparative Example 7

[0135] Compared with Example 2, Plant Composition 3 was removed, and Plant Composition 2 was increased to 4 parts, and the others were the same as Example 2.

[0136] Comparative Example 8

[0137] Compared with Example 2, only the amounts of each component were changed, as specifically shown in Table 1.

[0138] The specific preparation steps of the anti-dandruff shampoo containing selenium disulfide were the same as those in Example 2.

[0139] Comparative Example 9

[0140] Compared with Example 2, only the amounts of each component were changed, as specifically shown in Table 1.

[0141] The specific preparation steps of the anti-dandruff shampoo containing selenium disulfide were the same as those in Example 2.

[0142] Table 1. Formulations of Components of Examples 1 - 6 and Comparative Examples 1 - 7

[0143]

[0144] Physical and Chemical Value Detection

[0145] (1) pH Value Test

[0146] Samples of the shampoos described in Examples 1 - 6 and Comparative Examples 1 - 9 were taken and measured with a pH meter, and the measured pH values were between 4 and 6.

[0147] (2) Viscosity Test

[0148] Samples of the shampoos described in Examples 1 - 6 and Comparative Examples 1 - 9 were taken, the sample temperature was adjusted to 25 °C, and detected with a viscometer, and the measured viscosity values were 6000 - 10000 mPa•s.

[0149] Stability Test

[0150] Samples of the shampoos described in Examples 1 - 6 and Comparative Examples 1 - 9 were taken, packaged in transparent cosmetic bottles, and placed at -15 °C, 4 °C, 25 °C, and 45 °C respectively. The color, odor, and texture of the shampoos were investigated for three months. The test results showed that no adverse conditions occurred during the test, indicating good stability.

[0151] Efficacy Test 1: In Vitro Bacteriostatic Test

[0152] Experimental subjects: The anti-dandruff shampoos containing selenium disulfide prepared in Examples 1 - 6 and Comparative Examples 1 - 9 were used as test samples for antibacterial effect testing.

[0153] Experimental method: The antibacterial effect was detected by the antibacterial ring method. The medium used was agar medium, and the test strain was the standard strain of Malassezia furfur.

[0154] Experimental content:

[0155] 1. Prepare a bacterial suspension of about 10 5 CFU of Malassezia furfur. Uniformly coat it on the Leeming&Notman medium plate, and then place it in the sterile operating table to dry the bacterial liquid on the plate.

[0156] 2. Quantitatively add each shampoo sample to the above plate, and incubate it in a constant temperature incubator at 30°C for 5 - 7 days to observe the results and record the measurement of the antibacterial ring situation.

[0157] Experimental results: The recorded results were the diameter of the antibacterial ring, unit: mm.

[0158] Result determination refers to the standard of the National Committee for Clinical Laboratory Standards (NCCLS) of the United States: an antibacterial circle diameter < 8mm is insensitive, 8 - 13mm is lowly sensitive, 13 - 19mm is moderately sensitive, and > 19mm is highly sensitive. The test results are shown in Table 2.

[0159] Table 2. In vitro antibacterial test results

[0160]

[0161] As can be seen from Table 2, the diameters of the antibacterial rings in Examples 1 - 6 were all greater than 19mm, indicating that the test samples had significant antibacterial effects.

[0162] Efficacy test 2: Human patch test

[0163] Test substances: The shampoos containing selenium disulfide prepared in Examples 1 - 6 and Comparative Examples 1 - 9 were used as test samples for human patch testing.

[0164] Test subjects: There were 10 males and 10 females, aged 20 - 55 years old, a total of 20 people, who met the volunteer selection criteria for test subjects and were respectively tested in the blank control group, the example group, and the comparative example group.

[0165] Experimental method: The closed patch test was adopted. An equal amount (0.020 mL - 0.025 mL) of shampoo was placed in a specific patch tester, and then it was applied to the arm of the volunteer with a low-allergy tape. It was gently pressed to make it evenly adhere to the skin and left for 24 h. The blank control group was that the volunteer did not use the product. After 24 h, the patch tester was removed, and the skin reaction was observed at 0.5 h, 24 h, and 48 h, and the results were recorded. The adverse reaction grades of the skin are shown in Table 3 below.

[0166] Table 3. Adverse reaction grades of the skin

[0167]

[0168] The results of the human patch test are shown in Table 4 below:

[0169] Table 4. Results of the human patch test

[0170]

[0171] As can be seen from Table 4 above, among the 20 subjects, there were 0 cases of skin adverse reactions in Examples 1 - 6, Comparative Example 8, and Comparative Example 9. There were several cases of grade 1 adverse reactions in each of Comparative Examples 1 - 7. Comparative Examples 1 - 3 removed a certain plant composition on the basis of Example 2, and Comparative Examples 4 - 7 removed a certain plant composition on the basis of Example 2 and increased the content of another plant composition at the same time, indicating that the three plant compositions are indispensable and have a synergistic soothing effect. The absence of any component will lead to a significant decline in the effect.

[0172] Efficacy test 3: Human sensory evaluation and transdermal water loss rate test

[0173] Test substances: The selenium disulfide-containing shampoos prepared in Examples 1 - 6 and Comparative Examples 1 - 9 were used as test samples for the human patch test.

[0174] Subjects: People with obvious dandruff were randomly selected as subjects, aged 18 - 45 years old, a total of 120 people. According to their personal shampooing habits, they used the shampoos prepared in the examples and comparative examples of the present invention for 14 d and then were tested. The average value of the subjects was used for the statistical analysis of the test results. The evaluation grades were set as: 6 - excellent, 5 - good, 4 - relatively good, 3 - average, 2 - relatively poor, 1 - poor, a total of 6 grades, and the results are shown in Table 5.

[0175] Transdermal water loss rate experimental method: On the first day, the subject waits for 20 minutes under the conditions of a temperature of 25 ± 1°C and a humidity of 40 ± 10%, and then measures the transdermal water loss rate at about 10 cm from the palm on the arm (randomly select the left or right hand). After the test, the subject takes the sample home and uses it every night. On the 14th day after use, under the conditions of a temperature of 25 ± 1°C and a humidity of 40 ± 10%, wait for 20 minutes and then measure the transdermal water loss rate at about 10 cm from the palm on the arm. The German CK transdermal water loss probe Tewameter TM300 is used.

[0176] Table 5. Comprehensive table of usage experience

[0177]

[0178] As can be seen from Table 5, generally speaking, Examples 1 - 6 have outstanding performances in terms of foam amount, fluffiness, soothing itching and anti-dandruff effects.

[0179] For Examples 1 - 6, Comparative Examples 8 and 9, the transdermal water loss rate has been significantly reduced. For Comparative Examples 1 - 7, the reduction rate is relatively small. Comparative Examples 1 - 3 remove a certain plant composition on the basis of Example 2, and Comparative Examples 4 - 7 remove a certain plant composition on the basis of Example 2 and at the same time increase the content of another plant composition, indicating that the three compositions play a good role in scalp moisturization.

[0180] For Examples 1 - 6, Comparative Examples 8 and 9, the soothing itching scores are relatively high. For Comparative Examples 1 - 7, the soothing itching effects are not very good. Comparative Examples 1 - 3 remove a certain plant composition on the basis of Example 2, and Comparative Examples 4 - 7 remove a certain plant composition on the basis of Example 2 and at the same time increase the content of another plant composition, indicating that the addition of the three plant compositions helps to soothe itching and none of them can be missing.

[0181] The above results show that the selenium disulfide shampoo with three plant compositions added in the present invention plays a role in soothing, moisturizing and relieving itching on the basis of effective anti-dandruff, and solves the technical defects of using selenium disulfide as an anti-dandruff ingredient. The overall satisfaction with the use is relatively high.

[0182] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the protection scope of the present invention. Any simple modification or equivalent replacement of the technical solution of the present invention by those of ordinary skill in the art does not depart from the essence and scope of the technical solution of the present invention.

Claims

1. An anti-dandruff shampoo containing selenium disulfide, characterized in that: By mass, it contains the following components: 1 part of selenium disulfide, 20 parts of surfactant, 1 part to 3 parts of plant composition 1, 1 part to 3 parts of plant composition 2, 1 part to 3 parts of plant composition 3, 0.5 parts of preservative and 68.3 parts of water; The plant composition 1 is a mixture of a Bacillus fermentation product, an extract of a leaf or stem of Milo, p-hydroxyacetophenone and 1,2-pentanediol; the mass ratio of the Bacillus fermentation product, the extract of a leaf or stem of Milo, p-hydroxyacetophenone and 1,2-pentanediol is 1:0.3:0.3:0.1; The plant composition 2 is a mixture of Centella asiatica extract and propylene glycol; the mass ratio of the Centella asiatica extract to propylene glycol is 1:9; The plant composition 3 is a mixture of carob fruit extract, hydrolyzed lupine protein, sufang flower extract, ethylhexylglycerin, 1,2-hexanediol, glycerin and water; the mass ratio of the carob fruit extract, hydrolyzed lupine protein, sufang flower extract, ethylhexylglycerin, 1,2-hexanediol, glycerin and water is 1:0.9:1:0.1:1:25:21; The surfactant is sodium laureth sulfate, ammonium lauryl sulfate and cocamidopropyl betaine; The mass ratio of the sodium laureth sulfate, ammonium lauryl sulfate and cocamidopropyl betaine is 10-15:1-6:2-5.

2. The anti-dandruff shampoo according to claim 1, characterized in that The preservative is selected from at least two of phenoxyethanol, potassium sorbate, kasone, iodopropynyl butylcarbamate, ethylhexylglycerin, glyceryl laurate, glyceryl caprylate, sodium benzoate, benzyl alcohol, and sodium salicylate.

3. A method for preparing an anti-dandruff shampoo containing selenium disulfide according to any one of claims 1 to 2, characterized in that: The following steps are involved: Step 1: Mix water and surfactant, raise the temperature to 80-85°C, and keep the temperature for 20-40 minutes to obtain mixture 1; Step 2: Stir the mixture 1 and cool it to below 40° C., add selenium disulfide, plant composition 1, plant composition 2, plant composition 3 and a preservative, and stir evenly to obtain an anti-dandruff shampoo containing selenium disulfide.

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