Functional traditional Chinese medicine composition for improving gastrointestinal motility and application thereof

Abstract

The invention belongs to the technical field of medicines, and provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 18-22 parts of clove, 10-35 parts of radix ophiopogonis and one of the following raw materials. I: 10-20 parts of hawthorn; iI: 20-30 parts of immature bitter orange, 20-30 parts of dried orange peel, 20-35 parts of endothelium corneum gigeriae galli and 20-30 parts of cinnamon. The traditional Chinese medicine composition capable of improving gastrointestinal motility is obtained on the basis of traditional Chinese medicine ancient prescriptions, modern pharmacological research and clinical medication experience through a large number of composition efficacy tests. The components and dosage ratio of the traditional Chinese medicine composition supplement each other, so that the traditional Chinese medicine composition has the functional effects of warming the stomach, strengthening the spleen, promoting the circulation of qi, relieving dyspepsia and the like, is specially used for people with gastrointestinal motility dysfunction, helps the people to relieve gastrointestinal motility dysfunction diseases caused by gastrointestinal motility dysfunction, and is wide in application prospect. In addition, the components of the traditional Chinese medicine composition are all medicinal and edible traditional Chinese medicinal materials, so that the traditional Chinese medicine composition has few side effects and remarkable curative effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of Chinese medicine compositions, and more specifically, relates to a functional Chinese medicine composition for improving gastrointestinal motility and its application. Background Art

[0002] Gastrointestinal motility refers to the contraction peristalsis of gastrointestinal muscles, including the strength and frequency of muscle contraction. It is a very complex neuromuscular activity that can maintain the normal digestive function of the human body and is an important part of the physiological function of the digestive tract. Gastrointestinal motility disorder is one of the key factors causing a variety of gastrointestinal motility disorders, manifested as chronic motility and sensory disorders in a certain segment of the gastrointestinal tract. Gastrointestinal motility disorders (DGIM) refer to a number of gastrointestinal diseases caused by gastrointestinal motility disorders, mainly with various digestive tract symptoms as clinical manifestations, including functional dyspepsia, functional constipation, irritable bowel syndrome, gastroesophageal reflux disease, gastroparesis, etc.

[0003] The etiology and pathogenesis of gastrointestinal motility disorders are complex. Traditional Chinese medicine generally classifies this disease into the categories of "acid reflux", "fullness", "noise", "abdominal pain" and "constipation". The disease is located in the spleen and stomach, and is closely related to the lungs and large intestine. Its main pathogenesis is spleen and stomach weakness, and disorder of Qi movement, which leads to dysfunction of spleen and stomach transportation and weakened gastrointestinal motility, thus producing symptoms related to gastrointestinal motility diseases.

[0004] In recent years, the incidence of gastrointestinal motility diseases has gradually increased, and its mechanism has not yet been fully clarified. The clinical manifestations are diverse, often accompanied by multiple organs and systems involvement, difficult diagnosis, easy misdiagnosis, complex and diverse treatment plans, and low patient satisfaction with treatment. The main characteristics of the theoretical system of traditional Chinese medicine are the holistic view, the constant movement view, and the treatment based on syndrome differentiation, which are the advantages of treating gastrointestinal motility diseases. Therefore, it is of great practical significance to develop a Chinese medicine composition that has significant therapeutic effects on improving gastrointestinal motility diseases and has few side effects. Summary of the invention

[0005] The present invention aims to provide a traditional Chinese medicine composition, which can improve gastrointestinal motility and prevent and treat gastrointestinal motility disorders.

[0006] The first object of the present invention is to provide a Chinese medicine composition.

[0007] The second object of the present invention is to provide the application of the above-mentioned Chinese medicine composition.

[0008] The above-mentioned purpose of the present invention is achieved through the following technical solutions:

[0009] The present invention provides a traditional Chinese medicine composition, comprising the following raw materials in parts by weight: 18-22 parts of cloves, 10-35 parts of ophiopogon japonicus and one of the following;

[0010] I: 10-20 parts of hawthorn;

[0011] II: 20-30 parts of Citrus aurantium, 20-30 parts of dried tangerine peel, 20-35 parts of chicken's gizzard lining, and 20-30 parts of cinnamon bark.

[0012] When component I is selected, preferably, the traditional Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 10 parts of hawthorn, and 10 parts of ophiopogon japonicus.

[0013] As an optional implementation scheme, the Chinese medicine composition is composed of the following raw materials in parts by weight: 20 parts of cloves, 10 parts of hawthorn, and 10 parts of ophiopogon japonicus.

[0014] When component II is selected, preferably, the Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 20 parts of ophiopogon japonicus, 30 parts of immature bitter orange, 30 parts of dried tangerine peel, 30 parts of chicken gizzard lining, and 30 parts of cinnamon bark.

[0015] As an optional embodiment, the Chinese medicine composition is composed of the following raw materials in parts by weight: 20 parts of cloves, 20 parts of ophiopogon japonicus, 30 parts of immature bitter orange, 30 parts of dried tangerine peel, 30 parts of chicken gizzard lining, and 30 parts of cinnamon bark.

[0016] The invention also provides a traditional Chinese medicine composition, which contains the following raw materials in parts by weight: 18-22 parts of cloves, 10-20 parts of hawthorn, 10-35 parts of ophiopogon japonicus, 20-30 parts of immature bitter orange, 20-30 parts of dried tangerine peel, 20-35 parts of chicken gizzard lining and 20-30 parts of cinnamon bark.

[0017] Preferably, the Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 10-20 parts of hawthorn, 10-35 parts of ophiopogon japonicus, 20-25 parts of immature bitter orange, 20-25 parts of tangerine peel, 20 parts of chicken gizzard lining, and 20-25 parts of cinnamon.

[0018] As an optional embodiment, the Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 10 parts of hawthorn, 10 parts of ophiopogon japonicus, 20 parts of immature bitter orange, 20 parts of tangerine peel, 20 parts of chicken gizzard lining, and 20 parts of cinnamon.

[0019] As an optional embodiment, the Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 20 parts of hawthorn, 35 parts of ophiopogon japonicus, 25 parts of immature bitter orange, 25 parts of tangerine peel, 20 parts of chicken gizzard lining, and 25 parts of cinnamon.

[0020] The invention also provides a traditional Chinese medicine composition, which contains the following raw materials in parts by weight: 18-22 parts of cloves, 10-20 parts of hawthorn, 10-35 parts of ophiopogon japonicus, 20-30 parts of immature bitter orange, 20-35 parts of chicken's gizzard lining, and 20-30 parts of cinnamon bark.

[0021] Preferably, the Chinese medicine composition contains the following raw materials in parts by weight: 20 parts of cloves, 15 parts of hawthorn, 30 parts of ophiopogon japonicus, 25 parts of immature bitter orange, 35 parts of chicken gizzard lining, and 30 parts of cinnamon bark.

[0022] As an optional embodiment, the Chinese medicine composition is administered orally.

[0023] As an optional implementation scheme, the above-mentioned Chinese medicine composition is soaked in water according to the Chinese medicine pieces in the formula, and then 400-800mL of water is added and simmered over low heat to 80-120mL, and the original medicine juice is filtered for use; 400-800mL of water is added to the residue and simmered over low heat to 80-120mL of residue juice, and the above-mentioned original medicine juice and the residue juice are fully mixed to prepare a liquid medicine for oral administration.

[0024] The prescription of the Chinese medicine composition of the present invention is explained as follows:

[0025] Cloves are the dried flower buds of the Myrtaceae plant. As a commonly used medicinal material in traditional Chinese medicine, they are pungent in taste and warm in nature. They enter the spleen, stomach, lung, and kidney meridians. They have the functions of warming the stomach and promoting spleen function, promoting qi and lowering adverse reactions, promoting spleen and stomach function, and removing dampness and turbidity in the spleen and stomach. Modern pharmacological studies have shown that cloves can promote gastrointestinal motility and have significant effects on indigestion.

[0026] Ophiopogon japonicus is the dried root of a perennial herbaceous plant of the Liliaceae family. It is slightly cold in nature, sweet and slightly bitter in taste, and enters the heart, lung, and stomach meridians. It has the effects of nourishing yin and benefiting essence, nourishing yin and benefiting qi, clearing the heart and relieving troubles, and moistening the intestines and relieving constipation. Modern pharmacology has proved that Ophiopogon japonicus has the effects of promoting gastric emptying, enhancing gastric motility, and preventing gastric ulcers.

[0027] Hawthorn, the dried mature fruit of the deciduous shrub or small tree hawthorn, mountain red and wild hawthorn of the Rosaceae family, is divided into "Southern Hawthorn" and "Northern Hawthorn", and is a plant with both medicinal and edible properties. It tastes sweet and sour, is warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of digesting food and strengthening the stomach, promoting qi and dispersing blood stasis, and removing turbidity and reducing fat. Modern pharmacology shows that hawthorn is rich in various organic acids and lipase, which can promote the secretion of digestive enzymes in the stomach and promote digestion; it can increase the content of gastrin and motilin and promote gastrointestinal motility.

[0028] Citrus aurantium, the dried young fruit of the sour orange and its cultivated varieties or sweet orange of the genus Citrus in the Rutaceae family, was first recorded in "Shennong's Herbal Classic". It tastes bitter, sour and pungent, and is warm in nature. It enters the spleen, stomach and large intestine meridians. It has the effects of breaking up qi and eliminating accumulation, resolving phlegm and removing abdominal distension. Modern pharmacology has shown that Citrus aurantium is rich in active ingredients such as eriocitrin, naringin, hesperidin, etc., which can increase the levels of gastrin and motilin, regulate Caial interstitial cells and gastrointestinal smooth muscle to improve gastrointestinal motility, and thus promote gastrointestinal motility in rats with spleen deficiency model.

[0029] Tangerine peel is the mature peel of the citrus plant and its cultivated varieties of the Rutaceae family. It is warm in nature, bitter and pungent in taste, and enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is known as the first of the "Three Treasures of Guangdong" and has gradually become a commonly used medicine for digestive tract diseases such as the esophagus, stomach and duodenum. Modern pharmacology has confirmed that tangerine peel is rich in ingredients such as hesperidin, nobiletin and tangeretin, which can significantly promote the discharge of gastric juice and pepsin, improve the activity of pepsin, enhance digestive function, and promote intestinal peristalsis.

[0030] Chicken's gizzard lining is the inner wall of the gizzard of the domestic chicken, a pheasant family animal. It is sweet and flat, and enters the spleen, stomach, small intestine, and bladder meridians. It has the functions of invigorating the stomach and aiding food, astringing semen and stopping nocturnal emission, and relieving stranguria and dissolving stones. Modern pharmacology has confirmed that chicken's gizzard lining can enhance the levels of gastrin and motilin in rats with functional dyspepsia, increase the amount of gastric juice and pepsin excretion, and accelerate gastrointestinal motility and intestinal emptying rate.

[0031] Cinnamon bark is the dried bark of the cinnamon plant of the Lauraceae family, first recorded in Shennong's Herbal Classic, and listed as a top-grade product. It is pungent, sweet, and hot in nature. It enters the kidney, spleen, heart, and liver meridians, and has the effects of replenishing fire and yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians. Modern pharmacology has confirmed that cinnamon bark is rich in volatile components such as cinnamaldehyde and non-volatile components such as polysaccharides, diterpenes, polyphenols, and flavonoids. Cinnamon bark can enhance gastrointestinal health and promote the absorption of nutrients by regulating gastrointestinal flora and improving intestinal smooth muscle function.

[0032] The present invention has found that the above composition can help people with gastrointestinal motility disorders to alleviate the gastrointestinal motility disorders caused by them. Therefore, the present invention claims to protect the following application schemes:

[0033] Application of the above-mentioned Chinese medicine composition in the preparation of products for improving gastrointestinal motility.

[0034] Application of the above-mentioned Chinese medicine composition in the preparation of products for assisting the treatment of gastrointestinal motility disorders.

[0035] Specifically, the gastrointestinal motility disorders include functional dyspepsia, irritable bowel syndrome, functional constipation, reflux esophagitis and / or gastroparesis.

[0036] Application of the above-mentioned Chinese medicine composition in preparing a product for improving loss of appetite.

[0037] Application of the above-mentioned Chinese medicine composition in preparing products for improving nausea and vomiting.

[0038] As an alternative embodiment, the product comprises a medicament or a chewable (preferably chewing gum).

[0039] The Chinese medicine composition of the present invention can be prepared as a chewable, which can stimulate oral receptors through the mechanical movement process of chewing, further activate the vagus nerve, increase the secretion of gastrointestinal hormones, and further promote gastrointestinal motility.

[0040] The present invention has the following beneficial effects:

[0041] The present invention is based on traditional Chinese medicine prescriptions, modern pharmacological research and clinical medication experience, and after a large number of prescription efficacy tests, a Chinese medicine composition with improved gastrointestinal motility is obtained. The components and dosage ratios of the Chinese medicine composition complement each other, and can play the functional effects of warming the stomach and moving (strengthening) the spleen, promoting qi and eliminating stagnation, etc., specifically targeting people with gastrointestinal motility disorders, helping them to alleviate the gastrointestinal motility disorders caused thereby, such as functional dyspepsia, irritable bowel syndrome, functional constipation, reflux esophagitis, gastroparesis, etc., and has broad application prospects. In addition, the components of the Chinese medicine composition of the present invention are all Chinese medicinal materials that are both medicinal and edible, with few side effects and significant therapeutic effects. DETAILED DESCRIPTION

[0042] The present invention is further described below with reference to specific examples, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0043] Unless otherwise specified, the reagents and materials used in the following examples are commercially available.

[0044] Example 1

[0045] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 10g of hawthorn, and 10g of ophiopogon japonicus.

[0046] Example 2

[0047] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 10g of hawthorn, 10g of ophiopogon japonicus, 20g of immature bitter orange, 20g of dried tangerine peel, 20g of chicken gizzard lining, and 20g of cinnamon bark.

[0048] Example 3

[0049] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 20g of hawthorn, 35g of ophiopogon japonicus, 25g of immature bitter orange, 25g of dried tangerine peel, 20g of chicken gizzard lining, and 25g of cinnamon bark.

[0050] Example 4

[0051] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 20g of ophiopogon japonicus, 30g of immature bitter orange, 30g of dried tangerine peel, 30g of chicken gizzard lining, and 30g of cinnamon bark.

[0052] Example 5

[0053] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 15g of hawthorn, 30g of ophiopogon japonicus, 25g of immature bitter orange, 35g of chicken gizzard lining, and 30g of cinnamon bark.

[0054] Comparative Example 1

[0055] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 20g of hawthorn, 25g of immature bitter orange, 30g of tangerine peel, 30g of chicken gizzard lining, and 30g of cinnamon bark.

[0056] Comparative Example 2

[0057] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 15g of hawthorn, 30g of ophiopogon japonicus, 25g of tangerine peel, 35g of chicken gizzard lining, and 30g of cinnamon bark.

[0058] Comparative Example 3

[0059] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 10g of hawthorn, 35g of ophiopogon japonicus, 30g of immature bitter orange, 20g of dried tangerine peel, and 40g of cinnamon bark.

[0060] Comparative Example 4

[0061] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 10g of hawthorn, 35g of ophiopogon japonicus, 30g of immature bitter orange, 20g of dried tangerine peel, and 40g of chicken's gizzard lining.

[0062] Comparative Example 5

[0063] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 20g of hawthorn, 35g of immature bitter orange, 40g of chicken's gizzard lining, and 40g of cinnamon bark.

[0064] Comparative Example 6

[0065] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 10g of hawthorn, 40g of ophiopogon japonicus, 40g of immature bitter orange, and 35g of dried tangerine peel.

[0066] Comparative Example 7

[0067] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of cloves, 30g of ophiopogon japonicus, 30g of tangerine peel, 35g of chicken gizzard lining, and 40g of cinnamon bark.

[0068] Comparative Example 8

[0069] A traditional Chinese medicine composition comprises the following ingredients by weight: 20g of hawthorn, 20g of ophiopogon japonicus, 20g of immature bitter orange, 25g of dried tangerine peel, 20g of chicken gizzard lining, and 25g of cinnamon bark.

[0070] Comparative Example 9

[0071] A traditional Chinese medicine composition, comprising the following ingredients by weight: 20 g of cloves.

[0072] Example 6

[0073] The present invention has been studied extensively and summarized through clinical medication experience, and it is found that cloves, hawthorn, ophiopogon japonicus, immature bitter orange, dried orange peel, chicken's gizzard lining, and cinnamon bark have the effect of improving gastrointestinal motility through reasonable compatibility. The Chinese herbal combination components of different embodiments and comparative examples are as shown in Table 1 below in their proportions and dosages. According to the prescriptions of embodiments 1-5 and comparative examples 1-9, the Chinese herbal medicine pieces in the prescriptions are placed in room temperature cold water and soaked for more than 1 hour, and 3 bowls of water (about 600 mL) are slowly boiled over a slow fire (about 50-120° C.) to make half a bowl of water (about 100 mL), and the original medicine juice is filtered for standby use; the medicine residues are re-added with 3 bowls of water (about 600 mL) and slowly boiled over a slow fire to make a residue-turning medicine juice (about 100 mL), and the above-mentioned original medicine juice is fully mixed with the residue-turning medicine juice to prepare the medicinal liquids of different embodiments and comparative examples.

[0074] Table 1. Ratio and dosage of Chinese medicine combination

[0075]

[0076] Experimental Example 1 Clinical Test

[0077] In order to verify the clinical effectiveness and safety of the composition for improving gastrointestinal motility of the present invention, the experiment was carried out in accordance with the requirements of the guidelines for clinical research of new Chinese medicines, and the liquid medicines prepared in Examples 1-14 were used clinically and observed and studied. The patients drank 100 mL of the liquid medicine each time, twice a day.

[0078] 1. Clinical Data

[0079] A total of 140 patients with gastrointestinal motility disorders who visited the outpatient clinic or ward of the Department of Gastroenterology of Guangdong Second Hospital of Traditional Chinese Medicine from January 2022 to December 2023 were selected (see "II. Diagnostic Criteria" for specific Chinese and Western medicine diagnostic criteria and inclusion and exclusion criteria).

[0080] 2. Diagnostic Criteria

[0081] 1. Case selection criteria: Patients with gastrointestinal motility disorders such as functional dyspepsia, irritable bowel syndrome, reflux esophagitis, gastroparesis, functional constipation, etc., manifested by abdominal distension, early satiety, noisy, acid reflux, belching, nausea and vomiting, etc. Gastrointestinal motility disorders can be diagnosed if three of the above symptoms occur.

[0082] 1.1 Western medicine diagnostic criteria: Refer to the diagnostic criteria for functional dyspepsia, irritable bowel syndrome, reflux esophagitis, and functional constipation in the "2022 Chinese Expert Consensus on the Diagnosis and Treatment of Functional Dyspepsia", "2020 Chinese Expert Consensus on Irritable Bowel Syndrome", "Chinese Gastroesophageal Reflux Disease Diagnosis and Treatment Guidelines (2023)", and "Consensus on the Diagnosis and Treatment of Functional Constipation with Integrated Traditional Chinese and Western Medicine (2017)".

[0083] 1.2 TCM diagnostic criteria: refer to the diagnosis of "piman" in "Chinese Internal Medicine" and "Guidelines for Clinical Practice of Piman in TCM (2018)" edited by Zhang Boli et al., published by China National Traditional Chinese Medicine Press. TCM syndrome types refer to the diagnostic criteria for spleen and stomach weakness, food accumulation and qi stagnation in "Guidelines for Clinical Research of New Chinese Medicines (Trial)".

[0084] (1) Main symptoms: chest and stomach discomfort, vomiting, belching, acid reflux, poor appetite, loss of appetite, nausea and vomiting;

[0085] (2) Secondary symptoms: fatigue, constipation or loose stools, stomach pain;

[0086] (3) Tongue: thick and greasy tongue coating or pale tongue with a fat body and thin white coating;

[0087] (4) Pulse: slippery or deep, thin and weak.

[0088] 1.3 Inclusion criteria: ① Meet the diagnostic criteria of Western medicine; ② Meet the criteria of Chinese medicine for spleen and stomach weakness, food stagnation, qi stagnation and fullness; ③ Age 18-65 years old.

[0089] 1.4 Exclusion criteria: ① Patients with severe disease pathological diagnosis of suspected malignancy, or severe dysplasia of gastric mucosa; ② Patients with liver and kidney dysfunction, cardiovascular and cerebrovascular diseases; ③ Pregnant and lactating women; ④ Patients with language barriers and inability to cooperate or poor compliance; ⑤ Patients with drug allergies.

[0090] Study subjects: The observation cases were 140 randomly selected confirmed patients who met the above case selection criteria, including 70 males and 70 females.

[0091] 3. Treatment methods:

[0092] The patients were evenly divided into 14 groups, with 10 patients in each group (50% male and 50% female). The 14 groups of patients took the prepared drug solutions of Examples 1-5 and Comparative Examples 1-9 respectively. The patients took the drug solutions orally twice a day, 100 mL each time, for 14 consecutive days.

[0093] IV. Efficacy determination

[0094] The TCM syndrome score is scored before the patient is treated, and then scored again after treatment. The total score is calculated, and the treatment is considered effective if the difference in the TCM syndrome score before and after treatment is greater than or equal to 4.

[0095] Table 2 TCM syndrome score table

[0096]

[0097] 5. Treatment Outcomes

[0098] The scores of each patient before treatment are shown in Table 3, and the scores of each patient after treatment are shown in Table 4 (A1-A10 are the patient numbers). The TCM symptom scores of the patients before and after treatment were statistically analyzed, and the analysis results are shown in Table 5. The results show that the difference in the TCM symptom scores of the patients taking the medicinal liquids of Examples 1-5 before and after treatment is more than 4. Among them, the medicinal liquid of Example 1 has the largest difference, with a difference of 8.2, indicating that its therapeutic effect is the best. Next are Example 2 and Example 4, whose difference reaches more than 5, indicating that Examples 2 and 4 have better therapeutic effects. In summary, it has been proved through a large number of clinical trials that the Chinese medicine composition of the present invention can specifically target people with gastrointestinal motility disorders, improve gastrointestinal motility, and thus treat gastrointestinal motility disorders.

[0099] Table 3 TCM symptom scores of patients before treatment

[0100] Group A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 Example 1 12 15 10 13 9 11 12 10 8 13 Example 2 13 9 9 12 14 8 8 13 10 13 Example 3 11 13 9 12 9 11 8 12 10 9 Example 4 12 12 9 13 8 13 11 13 8 10 Example 5 11 8 12 10 8 12 10 12 9 11 Comparative Example 1 10 11 9 12 7 14 10 8 12 11 Comparative Example 2 13 9 10 12 8 13 12 10 11 10 Comparative Example 3 9 11 13 8 11 12 10 12 11 8 Comparative Example 4 12 9 12 8 12 13 9 12 10 9 Comparative Example 5 10 12 8 14 10 13 7 11 9 12 Comparative Example 6 11 13 9 10 12 10 12 10 8 8 Comparative Example 7 13 10 12 10 9 12 8 11 7 10 Comparative Example 8 9 10 13 13 11 10 7 10 12 8 Comparative Example 9 9 13 10 12 12 8 10 8 10 10

[0101] Table 4 TCM symptom scores of patients after treatment

[0102]

[0103]

[0104] Table 5 Statistical analysis results of TCM symptom scores of patients before and after treatment

[0105] Liquid Average before treatment After treatment, the average Difference Example 1 11.3 3.1 8.2 Example 2 10.9 5.4 5.5 Example 3 10.4 5.7 4.7 Example 4 10.9 5.4 5.5 Example 5 10.3 6.2 4.1 Comparative Example 1 10.4 6.6 3.8 Comparative Example 2 10.8 6.9 3.9 Comparative Example 3 10.5 7.5 3 Comparative Example 4 10.6 8.4 2.2 Comparative Example 5 10.6 8.4 2.2 Comparative Example 6 10.3 8.1 2.2 Comparative Example 7 10.2 7.8 2.4 Comparative Example 8 10.3 7.7 2.6 Comparative Example 9 10.2 8.2 2

[0106] The above embodiments are preferred implementation modes of the present invention, but the implementation modes of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications that do not deviate from the spirit and principles of the present invention should be equivalent replacement methods and are included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition, characterized in that: Contains the following raw materials in parts by weight: one of 18-22 parts of cloves and 10-35 parts of ophiopogon japonicus or less; I: 10-20 parts of hawthorn; II: 20-30 parts of Citrus aurantium, 20-30 parts of dried tangerine peel, 20-35 parts of chicken's gizzard lining, and 20-30 parts of cinnamon bark.

2. A Chinese medicine composition, characterized in that: The invention comprises the following raw materials in parts by weight: 20 parts of cloves, 10 parts of hawthorns and 10 parts of ophiopogon japonicus.

3. The Chinese medicine composition according to claim 2, characterized in that: The invention is composed of the following raw materials in parts by weight: 20 parts of cloves, 10 parts of hawthorns and 10 parts of ophiopogon japonicus.

4. A Chinese medicine composition, characterized in that: The invention contains the following raw materials in parts by weight: 18-22 parts of cloves, 10-20 parts of hawthorn, 10-35 parts of ophiopogon japonicus, 20-30 parts of immature bitter orange, 20-30 parts of dried tangerine peel, 20-35 parts of chicken's gizzard lining and 20-30 parts of cinnamon bark.

5. A Chinese medicine composition, characterized in that: The invention contains the following raw materials in parts by weight: 18-22 parts of cloves, 10-20 parts of hawthorn, 10-35 parts of ophiopogon japonicus, 20-30 parts of immature bitter orange, 20-35 parts of chicken's gizzard lining and 20-30 parts of cinnamon bark.

6. Use of the Chinese medicine composition according to claims 1-5 in the preparation of products for improving gastrointestinal motility.

7. Use of the Chinese medicine composition according to claims 1-5 in the preparation of products for assisting the treatment of gastrointestinal motility disorders.

8. The use according to claim 7, characterized in that: The gastrointestinal motility disorders include functional dyspepsia, irritable bowel syndrome, functional constipation, reflux esophagitis, and gastroparesis.

9. Use of the Chinese medicine composition according to claims 1-5 in preparing a product for improving loss of appetite.

10. Use of the Chinese medicine composition according to claims 1-5 in preparing products for improving nausea and vomiting.

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