Animal experiment highland environment simulation device
Patent Information
- Application Number
- CN202411742665.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-29
- Publication Date
- 2026-10-20
- Estimated Expiration
- 2044-11-29
AI Technical Summary
[0004]上述动物实验中,动物需要在动物舱中生存较长时间,此过程中需要进行动物投喂,还需要进行动物排泄物清理,需要打开动物舱,此时动物舱内进入外界空气,舱内便不能再保持高原环境,对实验的持续性有明显的影响
[0016]本发明的有益效果是:本发明常规使用状态如图1所示。如现有技术的是:动物位于动物舱内,环境调节装置使动物舱内空气状况与高原地区一致。开闭结构打开,升降装置使动物框位于动物舱底部。动物框内设置喂水喂食装置,动物可进入动物框进食饮水。由于开闭结构打开,临时舱内环境与动物舱内一致。
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Figure CN119605671B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of experimental equipment, and more particularly to a plateau environment simulation device for animal experiments. Background Technology
[0002] The environment in high-altitude areas differs significantly from that in low-altitude areas, including thinner air, lower air pressure, and lower oxygen content. People from low-altitude areas may experience altitude sickness, such as nausea, vomiting, palpitations, and dizziness, when they travel to high-altitude areas due to the different environment. They may even develop altitude sickness, including high-altitude pulmonary edema, high-altitude cerebral edema, and high-altitude polycythemia, due to their inability to adapt to the low-oxygen environment.
[0003] Using animal experiments to study the pathogenesis and prevention / treatment of certain diseases is a common research method in the medical field. Therefore, high-altitude environment simulation devices for animal experiments have emerged. A typical such device consists of a sealed animal chamber equipped with mechanisms to control air and lighting conditions within the chamber, ensuring an environment consistent with high-altitude regions. Placing animals inside the chamber effectively places them in a high-altitude environment, facilitating the simulation of animals moving from low to high altitudes for relevant animal research. Patent applications with application numbers 201510283490.5, 201921902600.1, and 200620085678.5 disclose such high-altitude environment simulation devices for animal experiments.
[0004] In the aforementioned animal experiments, the animals need to live in the animal chamber for a relatively long period of time. During this process, the animals need to be fed and their excrement needs to be cleaned up. The animal chamber needs to be opened, allowing outside air to enter. As a result, the high-altitude environment inside the chamber can no longer be maintained, which has a significant impact on the sustainability of the experiment. Summary of the Invention
[0005] The technical problem to be solved by the present invention is to provide a high-altitude environment simulation device for animal experiments in which animals are still in a high-altitude environment during animal feeding and excrement cleaning.
[0006] The technical solution adopted to solve the above-mentioned technical problems is as follows: The plateau environment simulation device for animal experiments includes an animal chamber and an environmental regulation device. The animal chamber is light-transmitting, and the environmental regulation device acts on the animal chamber. It also includes a device frame, a temporary chamber, an animal frame, a lifting device, an opening and closing structure, and a first clamping structure. The device frame includes a base, a horizontal pad, and a horizontal cover plate arranged sequentially from bottom to top. The horizontal pad has pad holes, and the horizontal cover plate has a first cover plate vent, a second cover plate vent, and a temporary compartment vent arranged at intervals. The temporary compartment vent is located between the first cover plate vent and the second cover plate vent. There are two animal compartments, each consisting of a main compartment body and a main cover. The main cover covers the main compartment body and has a first cover vent, a second cover vent, and a connecting hole. One animal compartment is positioned between a horizontal pad and a horizontal cover. A first clamping structure passes through a hole in the pad and pushes the animal compartment upwards to ensure the main cover is tightly fitted against the horizontal cover. The first cover vent, the second cover vent, and the connecting hole are respectively aligned with the first cover vent, the second cover vent, and the temporary compartment opening. The clamping of the first clamping structure can be released, and its clamping end can be moved to a position below the horizontal pad. The other animal compartment is reserved. The temporary cabin is smaller than the animal cabin. The temporary cabin includes a temporary cabin cover and a temporary cabin lid. The temporary cabin cover is connected to a horizontal cover plate and corresponds to the temporary cabin opening. The temporary cabin cover has an operating hole, and the temporary cabin lid closes the operating hole. The animal crate is located inside the animal cabin and directly below the temporary cabin. The animal crate is equipped with water and food. A lifting device is connected to the animal crate and can move the animal crate up and down so that the animal crate can be located inside the temporary cabin. An opening and closing structure is set at the bottom of the temporary cabin and can control whether the temporary cabin and the animal cabin are connected. The environmental control device includes an air intake device and an exhaust device, both of which are connected to a horizontal cover plate and correspond to the air holes of the first cover plate and the second cover plate, respectively.
[0007] Furthermore, the horizontal pad has a guide structure to guide the animal compartment to the designated position.
[0008] Furthermore, the animal compartment includes an inner bulkhead, and the main compartment has a padding strip that is spaced apart from the bottom of the main compartment. The inner bulkhead rests on the padding strip and has several drainage holes.
[0009] Furthermore, the first clamping structure includes a swing clamping frame and a first telescopic cylinder. The swing clamping frame is hinged to the device frame so that it can swing up and down. The two ends of the first telescopic cylinder are respectively hinged to the device frame and the swing clamping frame. The first telescopic cylinder can drive the swing clamping frame to swing.
[0010] Furthermore, the temporary hatch cover is provided with an annular pad that corresponds to the temporary hatch opening and is horizontally arranged; the opening and closing structure includes a second telescopic cylinder, a closing cover plate and a second pressing structure. The second telescopic cylinder is fixedly arranged and connected to the closing cover plate. The second telescopic cylinder can drive the closing cover plate to move horizontally so that the closing cover plate covers the annular pad plate or moves away. The second pressing structure is used to press the closing cover plate tightly when the closing cover plate covers the annular pad plate.
[0011] Furthermore, the second clamping structure includes a clamping plate and a third telescopic cylinder, with the third telescopic cylinder being fixed vertically and the clamping plate being connected to the lower end of the third telescopic cylinder.
[0012] Furthermore, the animal cage includes a frame body, a frame lid, and a frame lid actuator. The frame body has an animal inlet / outlet on its side, the frame lid covers the animal inlet / outlet, and the frame lid actuator can drive the frame lid to open and close.
[0013] Furthermore, the upper end of the frame cover is hinged to the frame body, and a connecting rod extending to the top of the frame body is provided at the upper end of the frame cover. The frame cover actuator is a fourth telescopic cylinder, and the two ends of the fourth telescopic cylinder are respectively hinged to the connecting rod and the frame body.
[0014] Furthermore, the animal frame includes a frame cover, and the upper end of the frame has an opening that corresponds to the position of the operating hole.
[0015] Furthermore, the lifting device is a fifth telescopic cylinder.
[0016] The beneficial effects of this invention are: In its normal use, this invention is as follows... Figure 1 As shown in the prior art: the animal is located in an animal enclosure, and an environmental control device keeps the air conditions inside the animal enclosure consistent with those in a high-altitude region. An opening and closing structure is opened, and a lifting device positions the animal crate at the bottom of the animal enclosure. Feeding and watering devices are installed inside the animal crate, allowing the animal to enter and eat and drink. Because the opening and closing structure is open, the environment inside the temporary enclosure is consistent with that inside the main animal enclosure.
[0017] When food and water need to be added, such as Figure 11 As shown, once all animals have left their enclosures, the lifting device moves the enclosures upwards into the temporary compartment, closing the opening and closing mechanism, thus separating the temporary compartment from the animal compartment. Opening the temporary compartment lid allows food and water to be added to the animal enclosures. Because the temporary compartment is connected to the outside, the internal air pressure becomes normal. Since the temporary compartment is separated from the animal compartment, it does not affect the environment inside the animal compartment. Then, the temporary compartment lid is closed to reseal the temporary compartment. The lifting device then moves the animal enclosures downwards into the animal compartment, and the device returns to its original position. Figure 1 The diagram shows the normal operating condition, where the air at normal pressure in the temporary compartment mixes with the air in the animal compartment. Because the temporary compartment is small and only the air from the temporary compartment can mix in, its impact on the animal compartment's environment is minimal. Therefore, throughout the process of adding food and water, the animal's environment remains essentially unchanged, maintaining the high-altitude environment.
[0018] When animal waste needs to be cleaned, add food and water to the animal enclosure, guide the animal into the enclosure, and then adjust the device to the desired position. Figure 11 The animal crate shown is located inside the temporary chamber, with the opening and closing mechanism closed. At this time, the temporary chamber maintains a high-altitude environment, and the animal is temporarily housed inside. Then, the first clamping mechanism is released. The animal chamber is then removed and replaced with a clean one, and the first clamping mechanism is used to clamp the animal chamber again. The environmental adjustment device is then activated, quickly adjusting the environment inside the animal chamber to a high-altitude state. The opening and closing mechanism then opens, and the lifting device lowers the animal crate into the animal chamber, returning the device to its original position. Figure 1The diagram shows the normal operating conditions. Throughout the process, the animals are in a high-altitude environment; the animal compartments are replaced quickly to obtain clean animal compartments, and the replaced animal compartments are cleaned and reused. The animals spend very little time in the closed temporary compartments, which has no adverse effects on them.
[0019] In summary, this invention maintains the animals in a high-altitude environment during the addition of food and water, as well as the cleaning of the animal cabins, thus preventing sudden changes in the animals' environment, ensuring that animal experiments can be conducted continuously for a long time, and facilitating the acquisition of more accurate experimental results. Attached Figure Description
[0020] Figure 1 This is a structural diagram of a plateau environment simulation device for animal experiments; Figure 2 It is a structural diagram of the device frame; Figure 3 This is a structural diagram of a horizontal pad. Figure 4 This is a structural diagram of a horizontal cover plate; Figure 5 This is a structural diagram of the animal cabin; Figure 6 This is the structural diagram of the first clamping structure; Figure 7 These are structural diagrams of the temporary cabin, animal enclosures, and opening / closing structure. Figure 8 This is the main view of the animal frame; Figure 9 This is the left view of the animal frame; Figure 10 It is the second clamping structure Figure 11 This is a diagram showing the animal enclosure's location within the temporary cabin. The components in the diagram are labeled as follows: Frame 1, Base 11, Horizontal Pad 12, Guide Structure 121, Pad Hole 122, Horizontal Cover 13, First Cover Air Hole 131, Temporary Compartment Hole 132, Second Cover Air Hole 133, First Pressing Structure 2, Swing Pressing Frame 21, First Telescopic Cylinder 22, Animal Compartment 3, Main Compartment 31, Pad Strip 311, Main Compartment Cover 32, First Compartment Cover Air Hole 321, Connecting Hole 322, Second Compartment Cover Air Hole 323, Inner Bulkhead 33 4. Temporary cabin 4. Temporary cabin cover 41. Operating hole 411. Annular pad 412. Temporary cabin cover 42. Animal frame 5. Frame body 51. Frame body cover 52. Frame cover 53. Fourth telescopic cylinder 54. Connecting rod 531. Opening and closing structure 6. Second telescopic cylinder 61. Sealing cover 62. Second pressing structure 63. Pressing plate 631. Third telescopic cylinder 632. Fifth telescopic cylinder 7. Environmental control device 8. Air intake device 81. Air exhaust device 82. Lighting device 83. Detailed Implementation
[0021] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.
[0022] like Figures 1 to 10 As shown, the plateau environment simulation device for animal experiments includes an animal chamber 3 and an environmental regulation device 8. The animal chamber 3 is light-transmitting, and the environmental regulation device 8 acts on the animal chamber 3. It also includes a device frame 1, a temporary chamber 4, an animal frame 5, a lifting device, an opening and closing structure 6, and a first clamping structure 2. The device frame 1 includes a base 11, a horizontal pad 12, and a horizontal cover 13 arranged sequentially from bottom to top. The horizontal pad 12 has pad holes 122, and the horizontal cover 13 has spaced-apart first cover vent holes 131, second cover vent holes 133, and temporary chamber holes 132. Hole 132 is located between the first cover plate vent 131 and the second cover plate vent 133; there are two animal compartments 3, each including a main compartment body 31 and a main compartment cover 32. The main compartment cover 32 covers the main compartment body 31 and has a first cover vent 321, a second cover vent 323, and a connecting hole 322; one animal compartment 3 is disposed between a horizontal pad 12 and a horizontal cover 13. A first pressing structure 2 passes through the pad hole 122 and pushes the animal compartment 3 to make the main cover 32 fit tightly against the horizontal cover 13. The first cover vent 321 and the second cover vent 323 are connected. 23 and the connecting hole 322 are respectively aligned with the first cover plate air hole 131, the second cover plate air hole 133 and the temporary cabin hole 132; the clamping of the first clamping structure 2 can be released and its clamping end can be moved to a position below the horizontal pad 12; another animal cabin 3 is reserved; the volume of the temporary cabin is smaller than that of the animal cabin 3, and the temporary cabin 4 includes a temporary cabin cover 41 and a temporary cabin lid 42. The temporary cabin cover 41 is connected to the horizontal cover plate 13 and corresponds to the temporary cabin hole 132. The temporary cabin cover 41 has an operating hole 411, and the temporary cabin lid 42 closes the operating hole 411; the animal frame 5 is located in the animal Inside cabin 3 and directly below temporary cabin 4, animal frame 5 is equipped with water and food; lifting device is connected to animal frame 5, which can drive animal frame 5 to move up and down so that animal frame 5 can be located inside temporary cabin 4; opening and closing structure 6 is correspondingly set at the bottom of temporary cabin 4, and opening and closing structure 6 can control whether temporary cabin 4 and animal cabin 3 are connected; environmental regulation device 8 includes air intake device 81 and exhaust device 82, both of which are connected to horizontal cover plate 13 and correspond to the first cover plate air hole 131 and the second cover plate air hole 133 respectively.
[0023] The conventional use of this invention is as follows: Figure 1 As shown in the prior art: the animal is located in the animal compartment 3, and the environmental control device 8 makes the air conditions inside the animal compartment 3 consistent with those in a high-altitude area. The opening and closing structure 6 is opened, and the lifting device 7 places the animal frame 5 at the bottom of the animal compartment 3. A feeding and watering device is installed inside the animal frame 5, allowing the animal to enter the animal frame 5 to eat and drink. Because the opening and closing structure 6 is open, the environment inside the temporary compartment 4 is consistent with that inside the animal compartment 3.
[0024] When food and water need to be added, such as Figure 11 As shown, once all animals have left the animal crate 5, the lifting device 7 moves the animal crate 5 upwards into the temporary compartment 4, and the opening and closing structure 6 closes, separating the temporary compartment 4 from the animal compartment 3. Opening the temporary compartment cover 42 allows food and water to be added to the animal crate 5. Because the temporary compartment 4 is connected to the outside, the internal air pressure becomes normal. Since the temporary compartment 4 is separated from the animal compartment 3, it does not affect the environment inside the animal compartment 3. Then, closing the temporary compartment cover 43 re-seales the temporary compartment 4. Then, the lifting device 7 moves the animal crate 5 downwards into the animal compartment 3, and the device returns to its original position. Figure 1 As shown in the normal operating state, the air at normal pressure in temporary compartment 4 mixes with the air in animal compartment 3. Because temporary compartment 4 is small in volume and only the air in temporary compartment 4 can mix into animal compartment 3, the impact on the environment inside animal compartment 3 is minimal. Therefore, throughout the process of adding food and water, the environment in which the animals are located remains basically unchanged, maintaining the high-altitude environment.
[0025] When animal excrement needs to be cleaned, add food and water to animal cage 5, introduce the animal into animal cage 5, and then adjust the device to the desired position. Figure 11 The animal crate 5 is located inside the temporary chamber 4, and the opening and closing mechanism 6 is closed. At this time, the temporary chamber 4 maintains a high-altitude environment, and the animal is temporarily located inside the temporary chamber 4. Then, the first clamping mechanism 2 is released. Then, the animal chamber 3 is moved out and replaced with a clean one, and then the first clamping mechanism 2 is used to clamp the animal chamber 3 again. Then, the environmental adjustment device 8 is turned on, and the environment inside the animal chamber 3 is quickly adjusted to a high-altitude environment. Then, the opening and closing mechanism 6 is opened, and the lifting device 7 lowers the animal crate 5 into the animal chamber 3, and the device returns to its original position. Figure 1 The diagram shows the normal operating conditions. Throughout the process, the animals are in a high-altitude environment; animal compartment 3 can be quickly replaced with a clean one, and the replaced animal compartment 3 is cleaned and put back into use. The animals spend very little time in the closed temporary compartment 4, which has no adverse effects on them.
[0026] In summary, this invention maintains the animals in a high-altitude environment during the addition of animal food and water, as well as the cleaning of the animal chamber 3, thus preventing sudden changes in the animals' environment, ensuring that animal experiments can be conducted continuously for a long time, and facilitating the acquisition of more accurate experimental results.
[0027] The environmental control device 8 can be designed according to existing technology, such as the patents with application numbers 201510283490.5, 201921902600.1, and 200620085678.5 mentioned in the background art. The air intake device 81 fills the animal chamber 3 with air of adjusted temperature and humidity, and the exhaust device 82 controls the exhaust of gas from the animal chamber 3, ensuring that the air pressure inside the animal chamber 3 is lower than the external environment. The environmental control device 8 may also include a lighting device 83, which is designed according to existing technology and is used to simulate high-altitude lighting. The temporary chamber 4 and the horizontal cover 13 should be light-transmitting, for example, transparent, so that the light emitted by the lighting device 83 can shine in. This invention has multiple sealed openings; to ensure a good seal, sealing gaskets or other sealing structures can be installed at these locations.
[0028] The specific process for removing the animal compartment 3 is as follows: the first clamping structure 2 is released, the animal compartment 3 is lowered onto the horizontal pad 12, and then pulled outward from the horizontal pad 12 to remove it from the device frame 1. The specific process for removing the cleaned spare animal compartment 3 is as follows: one end of the animal compartment 3 is placed on the horizontal pad 12, and then pushed inward to the designated position, that is, the first cover air hole 321, the second cover air hole 323, and the connecting hole 322 are respectively aligned with the first cover air hole 131, the second cover air hole 133, and the temporary compartment hole 132; then the first clamping structure 2 pushes up and clamps the animal compartment 3. In order to enable the animal compartment 3 to be quickly moved to the designated position during installation, it is preferable that the horizontal pad 12 has a guide structure 121 to guide the animal compartment 3 to the designated position. The guide structure 121 can be specifically as follows: Figure 3 As shown, the animal compartment 3 is U-shaped, with three sides of the animal compartment 3 fitting snugly against the three sides of the guide structure 121, thus positioning the animal compartment 3 in the designated location. This further improves the installation speed of the animal compartment 3.
[0029] The specific structure of the animal compartment 3 is as follows: The animal compartment 3 includes an inner partition 33. The main compartment 31 has a padding strip 311 spaced apart from the bottom surface of the main compartment 31. The inner partition 33 rests on the padding strip 311 and has several drainage holes. Animal urine and some feces can drain through these holes, helping to keep the inner partition 33 dry. Animals move around on the inner partition 33. After disassembling the animal compartment 3, the main compartment cover 32 can be opened, and the inner partition 33 can be removed for thorough cleaning. The animal compartment 3 can be made of plastic, making it lightweight and easier to replace.
[0030] The specific structure of the first clamping structure 2 can be as follows: Figure 6 As shown, the first clamping structure 2 includes a swing clamping frame 21 and a first telescopic cylinder 22. The swing clamping frame 21 is hinged to the device frame 1 so that it can swing up and down. The two ends of the first telescopic cylinder 22 are respectively hinged to the device frame 1 and the swing clamping frame 21. The first telescopic cylinder 22 can drive the swing clamping frame 21 to swing. The first telescopic cylinder 22 drives the clamping frame 2 to swing upward to clamp, and swing downward to release.
[0031] The specific structure of the opening and closing structure 6 is as follows: Figure 7 As shown, the temporary cabin cover 41 is provided with an annular pad 412 that corresponds to the temporary cabin opening 132 and is horizontally arranged; the opening and closing structure 6 includes a second telescopic cylinder 61, a closing cover 62, and a second pressing structure 63. The second telescopic cylinder 61 is fixedly arranged and connected to the closing cover 62. The second telescopic cylinder 61 can drive the closing cover 62 to move horizontally so that the closing cover 62 covers the annular pad 412 or moves away. The second pressing structure 63 is used to press the closing cover 62 when it covers the annular pad 412.
[0032] The second telescopic cylinder 61 extends and retracts to drive the movement of the closed cover plate 62, thereby controlling the opening and closing of the inner hole of the annular pad 412, and thus controlling whether the temporary compartment 4 and the animal compartment 3 are connected. However, simply covering the annular pad 412 with the closed cover plate 62 is not enough to guarantee a seal. Therefore, the second pressing structure 63 is needed to press the closed cover plate 62 tightly to ensure a seal between the cover plate 62 and the annular pad 412.
[0033] The specific structure of the second pressing structure 63 is as follows: The second pressing structure 63 includes a pressing plate 631 and a third telescopic cylinder 632. The third telescopic cylinder 632 is vertically fixed, and the pressing plate 631 is connected to the lower end of the third telescopic cylinder 632. The extension and retraction of the third telescopic cylinder 632 can cause the pressing plate 631 to press or release the closing cover plate 62.
[0034] The specific structure of animal frame 5 can be as follows: Figure 8 and Figure 9 As shown, the animal frame 5 includes a frame body 51, a frame cover 53, and a frame cover driver. The frame body 51 has an animal inlet and outlet on its side. The frame cover 53 covers the animal inlet and outlet, and the frame cover driver can drive the frame cover 53 to open and close.
[0035] The cover 53 and its actuator are used to control the opening and closing of the animal crate 5. When the animal crate 5 is inside the animal compartment 3, the cover 53 should normally be open to allow animals to enter and exit. When the animal crate 5 is to be moved to the temporary compartment 4, the cover 53 should be closed. When moving the animal crate 5 to the temporary compartment 4 with an animal, food and water can be placed inside the animal crate 5 to lure the animal in before closing the cover 53.
[0036] Specifically, the upper end of the frame cover 53 is hinged to the frame body 51. A connecting rod 531 extending above the frame body 51 is provided at the upper end of the frame cover 53. The frame cover actuator is a fourth telescopic cylinder 54, and the two ends of the fourth telescopic cylinder 54 are respectively hinged to the connecting rod 531 and the frame body 51. The animal frame 5 includes a frame cover 52. The upper end of the frame body 51 has an upper opening, which corresponds to the position of the operating hole 411.
[0037] The extension and retraction of the fourth telescopic cylinder 54 drives the frame cover 53 to rotate and open / close. The opening on the frame corresponds to the position of the operating hole 411. When the opening on the frame is opened, water and food can be added into the animal frame.
[0038] The lifting device is used to drive the animal frame 5 to rise and fall; its specific structure can be as follows: Figure 9 As shown, the lifting device is the fifth telescopic cylinder 7.
[0039] All telescopic cylinders in this invention can be electrically operated. Like common electrical appliances, this invention requires a conventional electrical control device. This device is relatively simple, capable of controlling the on / off operation of the invention, the switch of the environmental control device 8, and the extension and retraction of each telescopic cylinder. Multiple control buttons can be provided, allowing researchers to perform the aforementioned controls by pressing the buttons.
Claims
1. A plateau environment simulation device for animal experiments, comprising an animal chamber (3) and an environmental regulation device (8), wherein the animal chamber (3) is light-transmitting, and the environmental regulation device (8) acts on the animal chamber (3); characterized in that: It includes a device frame (1), a temporary compartment (4), an animal frame (5), a lifting device, an opening and closing structure (6), and a first clamping structure (2). The device frame (1) includes a base (11), a horizontal pad (12) and a horizontal cover plate (13) arranged sequentially from bottom to top. The horizontal pad (12) has a pad hole (122), and the horizontal cover plate (13) has a first cover plate air hole (131), a second cover plate air hole (133) and a temporary compartment hole (132) arranged at intervals. The temporary compartment hole (132) is located between the first cover plate air hole (131) and the second cover plate air hole (133). There are two animal compartments (3). Each animal compartment (3) includes a main compartment body (31) and a main compartment cover (32). The main compartment cover (32) covers the main compartment body (31) and has a first compartment cover vent (321), a second compartment cover vent (323), and a connecting hole (322). One animal compartment (3) is set between a horizontal pad (12) and a horizontal cover plate (13). A first clamping structure (2) passes through the pad hole (122) and... The top animal compartment (3) makes the main hatch cover (32) fit tightly against the horizontal cover plate (13). The first hatch cover air hole (321), the second hatch cover air hole (323) and the connecting hole (322) are respectively aligned with the first cover plate air hole (131), the second cover plate air hole (133) and the temporary compartment hole (132); the clamping of the first clamping structure (2) can be released and its clamping end can be moved to a position below the horizontal pad plate (12); another animal compartment (3) is reserved. The volume of the temporary cabin (4) is smaller than that of the animal cabin (3). The temporary cabin (4) includes a temporary cabin cover (41) and a temporary cabin cover (42). The temporary cabin cover (41) is connected to the horizontal cover plate (13) and corresponds to the temporary cabin hole (132). The temporary cabin cover (41) has an operation hole (411), and the temporary cabin cover (42) closes the operation hole (411). The animal frame (5) is located inside the animal cabin (3) and directly below the temporary cabin (4). The animal frame (5) is equipped with water and food. The lifting device is connected to the animal frame (5) and can drive the animal frame (5) to move up and down so that the animal frame (5) can be located inside the temporary cabin (4). The opening and closing structure (6) is correspondingly set at the bottom of the temporary cabin (4) and can control whether the temporary cabin (4) and the animal cabin (3) are connected. The environmental control device (8) includes an air intake device (81) and an exhaust device (82). Both the air intake device (81) and the exhaust device (82) are connected to the horizontal cover plate (13) and correspond to the first cover plate air hole (131) and the second cover plate air hole (133) respectively. When cleaning up animal excrement, add food and water to the animal box (5), introduce the animal into the animal box (5), and then place the animal box (5) in the temporary cabin (4). Close the opening and closing structure (6). At this time, the temporary cabin (4) still maintains the plateau environment, and the animal is temporarily located in the temporary cabin (4). Then loosen the first pressing structure (2); then move the animal cabin (3) out and replace it with a clean animal cabin (3), and then press the animal cabin (3) with the first pressing structure (2).
2. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The horizontal pad (12) has a guide structure (121) for guiding the animal compartment (3) to a designated position.
3. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The animal compartment (3) includes an inner partition (33), and the main compartment (31) has a pad (311) with a distance between it and the bottom surface of the main compartment (31). The inner partition (33) rests on the pad (311) and has several drainage holes.
4. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The first pressing structure (2) includes a swing pressing frame (21) and a first telescopic cylinder (22). The swing pressing frame (21) is hinged to the device frame (1) so that it can swing up and down. The two ends of the first telescopic cylinder (22) are respectively hinged to the device frame (1) and the swing pressing frame (21). The first telescopic cylinder (22) can drive the swing pressing frame (21) to swing.
5. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The temporary cabin cover (41) is provided with an annular pad (412) that corresponds to the temporary cabin opening (132) and is horizontally arranged; the opening and closing structure (6) includes a second telescopic cylinder (61), a closing cover (62) and a second pressing structure (63). The second telescopic cylinder (61) is fixedly arranged and connected to the closing cover (62). The second telescopic cylinder (61) can drive the closing cover (62) to move horizontally so that the closing cover (62) covers the annular pad (412) or moves away. The second pressing structure (63) is used to press the closing cover (62) when the closing cover (62) covers the annular pad (412).
6. The plateau environment simulation device for animal experiments according to claim 5, characterized in that: The second pressing structure (63) includes a pressing plate (631) and a third telescopic cylinder (632). The third telescopic cylinder (632) is fixed vertically, and the pressing plate (631) is connected to the lower end of the third telescopic cylinder (632).
7. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The animal frame (5) includes a frame body (51), a frame cover (53) and a frame cover driver. The frame body (51) has an animal inlet and outlet on its side. The frame cover (53) covers the animal inlet and outlet. The frame cover driver can drive the frame cover (53) to open and close.
8. The plateau environment simulation device for animal experiments according to claim 7, characterized in that: The upper end of the frame cover (53) is hinged to the frame body (51). The upper end of the frame cover (53) is provided with a connecting rod (531) extending to the top of the frame body (51). The frame cover driver is a fourth telescopic cylinder (54). The two ends of the fourth telescopic cylinder (54) are respectively hinged to the connecting rod (531) and the frame body (51).
9. The plateau environment simulation device for animal experiments according to claim 8, characterized in that: The animal frame (5) includes a frame cover (52), and the upper end of the frame (51) has an opening on the frame, which corresponds to the position of the operating hole (411).
10. The plateau environment simulation device for animal experiments according to claim 1, characterized in that: The lifting device is the fifth telescopic cylinder (7).
Citation Information
Patent Citations
A low-pressure chamber for experimental animals used for high-altitude medical research and a pressure control method based on the low-pressure chamber
CN104959171B
Plateau human disease model preparation environment simulation system
CN210743373U
Plateau-simulation animal experiment chamber
CN2907570Y
Normal pressure gas experiment animal cabin
CN102973330A
Animal feeding device capable of maintaining steady state of environment in chambers
CN104365494A