Application of 3-indolepropionic acid in improving reproductive performance of sows

Abstract

The invention relates to the technical field of feed additives, in particular to application of 3-indolepropionic acid to improvement of reproductive performance of sows. The 3-indolepropionic acid is added into the feed for the sows in the middle and later periods of pregnancy, is used for improving the reproductive performance of the sows, and has a remarkable effect, so that the use amount of antibiotics for health care can be reduced in the breeding process of the sows. The feed additive prepared from the 3-indolepropionic acid can improve the average litter live piglet weight and average litter healthy piglet number of the sows, improve the lactation ability of the sows and relieve the postpartum lochia condition of the sows.

Description

Technical Field

[0001] The invention relates to the technical field of feed additives, and in particular to application of 3-indolepropionic acid in the preparation of a feed additive for improving the reproductive performance of sows. Background Art

[0002] As the population's demand for pork continues to increase, ensuring pork supply has become a global concern. The failure of sows to discharge lochia after parturition is an important issue affecting their health and reproductive performance. If lochia is not discharged for a long time, it will cause uterine inflammation, prolong the postpartum recovery period, and then prolong the sow's empty period, affecting the next round of reproduction.

[0003] Although existing feed additives have a certain auxiliary effect on the postpartum recovery of sows, they are limited in terms of shortening the time of lochia discharge and improving uterine health. There is a lack of effective ingredients to accelerate lochia discharge and uterine repair, thereby improving reproductive traits.

[0004] Sows are prone to oxidative stress and inflammatory responses in the postpartum period. Oxidative stress not only prolongs the postpartum recovery period, but also damages uterine health. Existing antioxidants (such as vitamin E, etc.) have insufficient antioxidant activity and poor stability, and cannot effectively control postpartum stress.

[0005] Although current anti-inflammatory drugs are effective, they pose a risk of drug residues, are difficult to use for long-term use, and lack safety. Summary of the invention

[0006] The purpose of the present invention is to overcome the shortcomings of the prior art and provide an application of 3-indolepropionic acid in the preparation of a feed additive for improving the reproductive performance of sows. The present invention adds 3-indolepropionic acid to the feed of sows in the middle and late stages of pregnancy to improve the reproductive performance of pigs, which has a significant effect, thereby reducing the use of health-care antibiotics in the sow breeding process.

[0007] To achieve the above purpose, the technical solution designed by the present invention is as follows:

[0008] The present invention provides an application of 3-indolepropionic acid in improving the reproductive performance of sows. The present invention also provides an application of 3-indolepropionic acid in preparing a feed additive for improving the reproductive performance of sows.

[0009] The invention also provides a feed additive for improving the reproductive performance of sows, wherein the feed additive contains 3-indolepropionic acid.

[0010] The present invention also provides an application of 3-indolepropionic acid or the above feed additive in preparing feed for improving the reproductive performance of sows.

[0011] The present invention also provides a feed for improving the reproductive performance of sows, the feed comprising a basic feed and 3-indolepropionic acid or the above feed additive; wherein the mass fraction of 3-indolepropionic acid in the feed is 0.1% to 0.4%.

[0012] Furthermore, in the feed, the mass fraction of 3-indolepropionic acid is 0.2%.

[0013] Principle of the present invention:

[0014] 3-Indolepropionic acid (IPA) has good antioxidant and anti-inflammatory properties, which can effectively relieve oxidative stress and postpartum inflammation in sows, promote lochia discharge and uterine recovery, and improve reproductive performance.

[0015] Compared with traditional antioxidant and anti-inflammatory ingredients, IPA, as a natural compound, is highly safe and suitable for long-term application. It is expected to become an innovative feed additive to improve the reproductive performance of sows.

[0016] Beneficial effects of the present invention:

[0017] The invention uses 3-indolepropionic acid to prepare a feed additive for improving the reproductive performance of sows. The feed additive prepared by using 3-indolepropionic acid can increase the average live piglet weight and the average number of healthy piglets per litter of sows, and at the same time improves the lactation capacity of sows and alleviates the lochia condition of sows after parturition. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 The total scores of postpartum lochia in the control group and the experimental group;

[0019] Figure 2 is the average total litter size of the control group and the experimental group;

[0020] Figure 3 is the average live weight of the litter in the control group and the experimental group;

[0021] Figure 4 is the average number of live pups born in the control group and the experimental group;

[0022] Figure 5 is the average number of healthy pups born in the control group and the experimental group;

[0023] Figure 6 is the lactation capacity of sows in the control group and the experimental group. DETAILED DESCRIPTION

[0024] The present invention is further described in detail below in conjunction with specific embodiments so that those skilled in the art can understand.

[0025] Example 1

[0026] The feed additive is 3-indolepropionic acid, which is a solid powder.

[0027] Example 2

[0028] The feed for improving the reproductive performance of sows is prepared by directly mixing the feed additive with the basic feed. After mixing, the mass fraction of 3-indolepropionic acid in the feed is 0.2%.

[0029] 1. Verify the effect of the above feeds for improving sow reproductive performance on sow reproductive performance:

[0030] 1. Methods

[0031] Sow grouping and feeding: 68 multiparous Landrace sows at 85 days of gestation were randomly divided into two groups: a control group (Control, n=38) and an experimental group (IPA, n=30).

[0032] Control group: fed with basal diet (the basal diet is the sow diet formula);

[0033] Experimental group: fed with a diet that improves the reproductive performance of sows.

[0034] The experiment lasted until the sows were 7 days postpartum, a total of 36 days. Sow diet formula (percentage, based on dry matter): corn: 63.90%, soybean meal 46: 20.00%, fish meal: 3.00%, puffed soybean: 4.70%, bran: 4.00%, monocalcium phosphate: 0.95%, stone powder: 1.15%, soybean oil: 1.00%, salt: 0.30%, 1% premix: 1.00%.

[0035] Collection of phenotypic data: Phenotypic data related to the reproductive performance of sows are collected after farrowing. Mainly including: total number of piglets per litter (head), number of live piglets per litter (head), average number of healthy piglets per litter (head), live piglet weight per litter (kg) and sow's lactation capacity (kg). The lactation capacity of sows is evaluated by the difference between weaning litter weight and live piglet weight per litter. In addition, after farrowing, the sow's body temperature and lochia are monitored and recorded.

[0036] The lochia of sows was continuously counted from the 2nd to the 7th day after farrowing and scored according to the severity. The criteria are as follows:

[0037] a. Dry or moist vulva was scored as 0 points;

[0038] b. A small amount of white or yellowish-white pus was scored as 1 point;

[0039] c. More yellow-white pus or a large amount of white pus is scored as 3 points. The lochia scores of each sow from 2 to 7 days after delivery are accumulated as an evaluation index of the severity of its postpartum lochia. A score of less than 3 indicates health, 3-4 indicates mild disease, and 4 or more indicates severe disease.

[0040] 2. Conclusion

[0041] like Figure 1 As shown: Compared with the control group that was fed a basic diet, the experimental group (fed with feed that improved the reproductive performance of sows) could significantly alleviate the postpartum lochia of sows.

[0042] As shown in Table 1: Compared with the control group that was fed a basic diet, the experimental group (fed with feed that improves the reproductive performance of sows) tended to alleviate the high fever of sows within three days after parturition.

[0043] Table 1 Body temperature of the control group and the experimental group on the third day after delivery

[0044]

[0045] like Figure 2 As shown: Compared with the control group fed with a basic diet, the experimental group (fed with a feed that improves the reproductive performance of sows) can significantly increase the total number of piglets born per litter.

[0046] like Figures 3 to 5 As shown in the figure: Compared with the control group that was fed with a basic diet, the experimental group (fed with a feed that improves the reproductive performance of sows) can significantly increase the average live piglet weight of sows ( Figure 4 ), average number of live piglets born per litter ( Figure 5 ) and the average number of healthy pups per litter ( Figure 6 ).

[0047] like Figure 6 As shown: Compared with the control group fed with a basic diet, the experimental group (fed with feed that improves the reproductive performance of sows) can significantly improve the lactation ability of sows.

[0048] Although the above embodiments have been described in detail, they are only a part of the embodiments of the present invention, not all of them. People can also obtain other embodiments based on this embodiment without creativity, and these embodiments all belong to the protection scope of the present invention.

Claims

1. An application of 3-indolepropionic acid in improving the reproductive performance of sows.

2. An application of 3-indolepropionic acid in the preparation of a feed additive for improving the reproductive performance of sows.

3. A feed additive for improving the reproductive performance of sows, characterized in that: The feed additive contains 3-indolepropionic acid.

4. Use of 3-indolepropionic acid or the feed additive according to claim 3 in preparing feed for improving the reproductive performance of sows.

5. A feed for improving the reproductive performance of sows, characterized in that: The feed comprises a basic feed and 3-indolepropionic acid or the feed additive according to claim 3; wherein the mass fraction of 3-indolepropionic acid in the feed is 0.1% to 0.4%.

6. The feed according to claim 5, characterized in that: In the feed, the mass fraction of 3-indolepropionic acid is 0.2%.

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