Traditional Chinese medicine-probiotic composition for protecting liver and benefiting intestines and preparation method thereof

Abstract

The composition is prepared from the following raw materials in parts by weight: 3 to 7 parts of poria cocos, 3 to 8 parts of liquorice root, 3 to 8 parts of fructus lycii, 4 to 7 parts of fructus crataegi, 8 to 15 parts of semen hoveniae, 2 to 5 parts of orange peel, 2 to 5 parts of lucid ganoderma, 5 to 15 parts of radix puerariae, 5 to 15 parts of semen cassiae, 4 to 8 parts of corn peptide and 0.1 to 0.5 part of freeze-dried probiotic powder. The traditional Chinese medicine composition consists of a plurality of traditional Chinese medicine components which are homologous in medicine and food, the corn active peptide and the probiotic freeze-dried powder, and the traditional Chinese medicine components all belong to foods which can be properly eaten, have no toxic or side effect, have good liver protection activity, and are comprehensive in effect and easy to absorb. Wherein the added corn active peptide can enhance immunity and promote digestion, and is matched with various probiotics to regulate intestinal flora and improve the digestion and absorption capacity of intestinal tracts, and multiple components are coordinated to better play a role in protecting liver and benefiting intestines.

Description

Technical Field

[0001] The invention belongs to the field of food, and in particular relates to a liver-protecting and intestinal-benefiting traditional Chinese medicine-probiotic composition and a preparation method thereof. Background Art

[0002] The liver is an important organ in the body with metabolic functions as the main function. It has important physiological functions such as digestion, detoxification, metabolism, synthesis, and secretion. It plays an important role in maintaining the metabolism of carbohydrates, proteins, fats, vitamins, and hormones. It can participate in the body's biochemical reactions through oxidation, reduction, hydrolysis, and combination, and realize the biotransformation of non-nutritional substances from inside and outside the body, such as drugs, poisons, and metabolites in the body. However, viral infection, excessive drinking, metabolic disorders, etc. may cause damage to liver cells, which in turn cause liver diseases such as fatty liver, viral hepatitis, liver cysts, cirrhosis, liver abscesses, etc.

[0003] Fatty liver is one of the most common liver diseases, which refers to the lesions caused by excessive fat accumulation in liver cells due to various reasons. In recent years, with the improvement of living standards and changes in people's lifestyles, the incidence of fatty liver has also increased. Most patients with mild fatty liver do not need to undergo drug treatment. They can mainly adjust their personal diet structure, strictly control their personal diet, avoid overnutrition, control their weight, avoid drinking, and increase exercise appropriately. A large amount of evidence shows that many medicinal and edible medicinal materials or foods have liver protection functions. Some patients with fatty liver can be supplemented with medicinal and edible foods that protect the liver to prevent or control fatty liver. Existing liver protection and liver health foods are mainly used to treat the liver, but fatty liver can aggravate intestinal flora imbalance, and intestinal flora imbalance is also one of the important causes of fatty liver disease. Therefore, the present invention provides a Chinese medicine-probiotic composition for protecting the liver and benefiting the intestines and a preparation method thereof to improve the prevention and treatment effects of fatty liver. Summary of the invention

[0004] Aiming at the technical problem that the existing liver-protecting and liver-health care foods mainly treat the liver and ignore the intestinal function, the present invention proposes a liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition and a preparation method thereof, which has good effects.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] A liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition is prepared from the following raw materials in parts by weight: 3-7 parts of Poria cocos, 3-8 parts of liquorice, 3-8 parts of wolfberry, 4-7 parts of hawthorn, 8-15 parts of Hovenia dulcis, 2-5 parts of tangerine peel, 2-5 parts of Ganoderma lucidum, 5-15 parts of Pueraria root, 5-15 parts of Cassia seed, 4-8 parts of corn peptide, and 0.1-0.5 parts of probiotic freeze-dried powder.

[0007] Preferably, the probiotic freeze-dried powder includes freeze-dried powder of Bifidobacterium lactis, freeze-dried powder of Lactobacillus plantarum, freeze-dried powder of Lactobacillus rhamnosus and freeze-dried powder of Bifidobacterium bifidum.

[0008] Preferably, it is made of the following components in parts by weight: 5 parts of Poria cocos, 5 parts of licorice, 5 parts of wolfberry, 3 parts of hawthorn, 10 parts of Hovenia dulcis, 3 parts of orange peel, 3 parts of Ganoderma lucidum, 10 parts of Pueraria root, 10 parts of Cassia seed, 5 parts of corn peptide, 0.05 parts of Bifidobacterium lactis freeze-dried powder, 0.05 parts of Lactobacillus plantarum freeze-dried powder, 0.05 parts of Lactobacillus rhamnosus freeze-dried powder, and 0.05 parts of Bifidobacterium bifidum freeze-dried powder.

[0009] Preferably, the Ganoderma lucidum is purple Ganoderma lucidum, red Ganoderma lucidum or mulberry lindera Ganoderma lucidum.

[0010] The invention also proposes a method for preparing a liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition, comprising the following steps:

[0011] (1) Weigh 3-7 parts of Poria cocos, 3-8 parts of Licorice, 3-8 parts of Lycium barbarum, 4-7 parts of Hawthorn, 8-15 parts of Hovenia dulcis, 2-5 parts of Citrus aurantium, 2-5 parts of Ganoderma lucidum, 5-15 parts of Pueraria root, and 5-15 parts of Cassia seed, grind them, add 8-12 parts by weight of water, soak them for 1 hour, heat them to boiling and boil them for 1 hour, filter and separate the filtrate, add 6-8 parts by weight of water to the residue and boil them again for 1 hour, combine the filtrates obtained from the two decoctions, concentrate them into a paste, and further dry them to obtain a Chinese medicine powder;

[0012] (2) Take 4-8 portions of corn peptide, add 2-5 times the weight of corn peptide in water to dissolve, dialyze the solution with a dialysis bag with a pore size of less than or equal to 10 kD, collect the dialysate, and lyophilize to obtain the active peptide;

[0013] (3) Weigh 0.05 parts each of Bifidobacterium lactis freeze-dried powder, Lactobacillus plantarum freeze-dried powder, Lactobacillus rhamnosus freeze-dried powder, and Bifidobacterium bifidum freeze-dried powder;

[0014] (4) The Chinese medicine powder prepared in step (1), the active peptide freeze-dried powder prepared in step (2), and the probiotic freeze-dried powder are mixed uniformly to obtain a composition.

[0015] Among the above ingredients, Poria cocos, licorice, wolfberry, hawthorn, Hovenia dulcis, orange peel, Ganoderma lucidum, Pueraria root, and Cassia seed are all Chinese medicinal materials that can be used as food and have certain therapeutic effects. According to the historical records of traditional Chinese medicine, the above Chinese medicinal materials have the following pharmacological activities and functional indications:

[0016] Poria cocos is sweet, light, and neutral in nature. It enters the heart, lung, spleen, and kidney meridians and has the effects of dispelling dampness and promoting diuresis, strengthening the spleen and stomach, and calming the mind.

[0017] Licorice root, sweet in taste, neutral in nature, enters the spleen, stomach, and lung meridians, has the effects of replenishing qi and tonifying the middle, relieving pain, moistening the lungs and relieving cough, purging fire and detoxifying, and harmonizing various medicines;

[0018] Lycium barbarum is sweet and neutral in nature. Traditional Chinese medicine believes that it can replenish liver yin, nourish liver blood, improve essence and improve eyesight. Modern pharmacological research has shown that Lycium barbarum can lower blood sugar, inhibit fat deposition in liver cells, promote liver cell regeneration, and has a blood pressure lowering effect;

[0019] Hawthorn tastes sour, sweet, and slightly warm in nature. It enters the spleen, stomach, and liver meridians. It has the effects of digesting food and eliminating accumulation, promoting blood circulation and removing blood stasis, clearing turbidity and reducing fat.

[0020] Pueraria root is sweet, pungent and cool in nature and enters the spleen and stomach meridians. It has the effects of detoxifying alcohol, invigorating the spleen and stomach, and quenching thirst. Pueraria root contains isoflavones such as puerarin, daidzein, and daidzein, which can inhibit alcohol intake, reduce alcohol concentration, regulate alcohol metabolism, and reduce damage to the liver, the most important organ for alcohol metabolism. At the same time, Pueraria root has a certain effect on hypertension, hyperlipidemia, hyperglycemia, and cardiovascular and cerebrovascular diseases.

[0021] Tangerine peel has the effects of regulating qi and relieving adverse reactions, regulating the middle and stimulating appetite, and drying up dampness and resolving phlegm. It is mainly used to treat spleen and stomach qi stagnation and dampness obstruction, chest fullness and stuffiness, abdominal distension and pain, loss of appetite, vomiting, constipation, lung qi obstruction, cough and excessive phlegm, etc.

[0022] Hovenia dulcis is mild in nature and sweet in taste. It enters the lung and spleen meridians, relieves alcohol and stops vomiting, dispels wind and dredges the meridians, eliminates dampness and heat, and promotes bowel movements. The chemical components of Hovenia dulcis include flavonoids, saponins, glycosides, alkaloids, and fatty acids. Its pharmacological effects include the effects of relieving alcohol, protecting liver cells, and anti-mutation and anti-tumor.

[0023] Lingzhi is sweet and mild in nature, and enters the heart, lung, liver, and kidney meridians. It has the effects of replenishing qi and blood, nourishing the heart and calming the mind. The main active ingredients are amino acids, peptides, proteins, fungal lysozyme, as well as sugars and triterpenes. It has the effects of protecting the liver and detoxifying, enhancing the functions of the heart and lungs, increasing blood oxygen, regulating the functions of the five internal organs, and strengthening the body.

[0024] Cassia seed tastes sweet, bitter and salty, is slightly cold in nature, and enters the liver and large intestine meridians. It has the effects of clearing the liver and improving eyesight, moistening the intestines and promoting bowel movements, lowering blood pressure and lowering blood lipids.

[0025] In addition, corn peptide is a bioactive peptide extracted from corn that has the effects of enhancing immunity, promoting digestion and improving cardiovascular health.

[0026] Compared with the prior art, the advantages and positive effects of the present invention are:

[0027] The liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition of the present invention is composed of a variety of Chinese medicine ingredients that are both medicinal and edible, corn active peptides and probiotic freeze-dried powder, wherein the Chinese medicine ingredients are all foods that can be eaten in moderation, are basically non-toxic and have no side effects, and have good liver-protecting and liver-protecting activity, have comprehensive effects, and are easy to absorb. Adding corn active peptides can enhance immunity and promote digestion, cooperate with a variety of probiotics, regulate intestinal flora, improve intestinal digestion and absorption capacity, and have a certain effect on treating fatty liver. The synergistic effect of the various ingredients can better play the effect of liver protection and intestinal benefit. DETAILED DESCRIPTION

[0028] In order to better understand the present invention, the following is a detailed description with reference to the embodiments.

[0029] Example:

[0030] A liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition is prepared from the following raw materials in parts by weight: 5 parts of Poria cocos, 5 parts of liquorice, 5 parts of wolfberry, 3 parts of hawthorn, 10 parts of Hovenia dulcis, 3 parts of orange peel, 3 parts of Ganoderma lucidum, 10 parts of Pueraria root, 10 parts of Cassia seed, 5 parts of corn peptide, 0.05 parts of Bifidobacterium lactis freeze-dried powder, 0.05 parts of Lactobacillus plantarum freeze-dried powder, 0.05 parts of Lactobacillus rhamnosus freeze-dried powder, and 0.05 parts of Bifidobacterium bifidum freeze-dried powder.

[0031] The liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition is prepared by the following method, which specifically comprises the following steps:

[0032] (1) Preparation of Chinese medicine powder

[0033] Weigh 5 parts of Poria cocos, 5 parts of licorice, 5 parts of wolfberry, 3 parts of hawthorn, 10 parts of Hovenia dulcis, 3 parts of tangerine peel, 3 parts of Ganoderma lucidum, 10 parts of Pueraria root, and 10 parts of Cassia seed, grind them, add 10 parts by weight of water containing all the above ingredients and soak them for 1 hour, then heat to boiling and boil for 1 hour, filter and separate the filtrate, add 6 parts by weight of water to the residue and boil again for 1 hour, combine the filtrates obtained from the two decoctions and concentrate them into a paste, further dry them to obtain Chinese medicine powder, and grind them to obtain Chinese medicine powder.

[0034] (2) Preparation of active peptides

[0035] Take 5 parts of corn peptide, add water 4 times the weight of corn peptide to dissolve it, dialyze the solution with a dialysis bag with a pore size of less than or equal to 10kD, collect the dialysate, and lyophilize to obtain active peptide.

[0036] (3) Weigh 0.05 parts of each of Bifidobacterium lactis freeze-dried powder, Lactobacillus plantarum freeze-dried powder, Lactobacillus rhamnosus freeze-dried powder and Bifidobacterium bifidum freeze-dried powder.

[0037] (4) Preparation of composition

[0038] The Chinese medicine powder prepared in step (1), the active peptide freeze-dried powder prepared in step (2) and the probiotic freeze-dried powder are evenly mixed to obtain a liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition.

[0039] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A Chinese medicine-probiotic composition for protecting liver and benefiting intestines, characterized in that: The invention is prepared from the following raw materials in parts by weight: 3-7 parts of Poria cocos, 3-8 parts of licorice, 3-8 parts of wolfberry, 4-7 parts of hawthorn, 8-15 parts of Hovenia dulcis, 2-5 parts of tangerine peel, 2-5 parts of Ganoderma lucidum, 5-15 parts of Pueraria root, 5-15 parts of Cassia seed, 4-8 parts of corn peptide and 0.1-0.5 parts of probiotic freeze-dried powder.

2. The liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition according to claim 1, characterized in that: The probiotic freeze-dried powder includes freeze-dried powder of Bifidobacterium lactis, freeze-dried powder of Lactobacillus plantarum, freeze-dried powder of Lactobacillus rhamnosus and freeze-dried powder of Bifidobacterium bifidum.

3. The liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition according to claim 2, characterized in that: The invention is prepared from the following components in parts by weight: 5 parts of Poria cocos, 5 parts of Licorice, 5 parts of Lycium barbarum, 3 parts of Hawthorn, 10 parts of Hovenia dulcis, 3 parts of Citrus aurantium, 3 parts of Ganoderma lucidum, 10 parts of Pueraria root, 10 parts of Cassia seed, 5 parts of Corn peptide, 0.05 parts of Bifidobacterium lactis freeze-dried powder, 0.05 parts of Lactobacillus plantarum freeze-dried powder, 0.05 parts of Lactobacillus rhamnosus freeze-dried powder and 0.05 parts of Bifidobacterium bifidum freeze-dried powder.

4. The liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition according to claim 2, characterized in that: The ganoderma lucidum is purple ganoderma lucidum, red ganoderma lucidum or mulberry tinctoria ganoderma.

5. A method for preparing a liver-protecting and intestinal-benefiting Chinese medicine-probiotic composition, characterized in that: The following steps are involved: (1) Weigh 3-7 parts of Poria cocos, 3-8 parts of Licorice, 3-8 parts of Lycium barbarum, 4-7 parts of Hawthorn, 8-15 parts of Hovenia dulcis, 2-5 parts of Citrus aurantium, 2-5 parts of Ganoderma lucidum, 5-15 parts of Pueraria root, and 5-15 parts of Cassia seed, grind them, add 8-12 parts by weight of water, soak them for 1 hour, heat them to boiling and boil them for 1 hour, filter and separate the filtrate, add 6-8 parts by weight of water to the residue and boil them again for 1 hour, combine the filtrates obtained from the two decoctions, concentrate them into a paste, and further dry them to obtain a Chinese medicine powder; (2) Take 4-8 portions of corn peptide, add 2-5 times the weight of corn peptide in water to dissolve, dialyze the solution with a dialysis bag with a pore size of less than or equal to 10 kD, collect the dialysate, and lyophilize to obtain the active peptide; (3) Weigh 0.05 parts each of Bifidobacterium lactis freeze-dried powder, Lactobacillus plantarum freeze-dried powder, Lactobacillus rhamnosus freeze-dried powder, and Bifidobacterium bifidum freeze-dried powder; (4) The Chinese medicine powder prepared in step (1), the active peptide freeze-dried powder prepared in step (2), and the probiotic freeze-dried powder are mixed uniformly to obtain a composition.