A traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold regions of northern China

Abstract

The present invention discloses a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold regions in the north, belonging to the technical field of traditional Chinese veterinary medicine. It is made of the following components in parts by weight: 16-24 parts of cinnamon twig, 16-24 parts of raw white peony root, 8-12 parts of honeysuckle flower, 8-12 parts of dandelion, 8-12 parts of great burdock achene, 8-12 parts of divaricate saposhnikovia root, 3-7 parts of honey and 3-7 parts of licorice root. The traditional Chinese veterinary medicine composition prepared in Example 1 of the present invention is used to feed newborn calves for preventing respiratory diseases, and the incidence rate can be reduced by 40%. When using this traditional Chinese veterinary medicine composition to treat the respiratory diseases of newborn calves, compared with the treatment group using cefotaxime sodium alone, the cure rate is increased by 13.6%, and the cure time is reduced by 36.24 h.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese veterinary medicine, and particularly to a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newly born calves in cold northern regions. Background Art

[0002] Bovine respiratory disease (BRD) is one of the common diseases in breeding. Bovine respiratory disease not only increases the culling rate of calves, affects the daily weight gain of calves, causes slow growth, increases breeding costs, but also affects the growth during the growing period and prolongs the market time of beef cattle.

[0003] The biological characteristics of cattle cause them to be more inclined to conceal their own symptoms. In the original wild state, calves will self-conceal the external manifestations of diseases to prevent attracting the attention of predators. This instinct still exists in the existing cattle herds. Therefore, when many breeders find that calves are sick, the disease is already very serious, and varying degrees of lung damage are often caused when clinical symptoms appear. In addition, the highly contagious nature of respiratory diseases can spread to more susceptible animals before the discovery of subclinically infected animals, resulting in large-scale outbreaks of the disease. Therefore, it is urgently necessary to provide a solution for preventing and treating respiratory diseases of newly born calves. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newly born calves in cold northern regions to solve the problems existing in the above-mentioned prior art. The northern region is cold and dry, and respiratory diseases are highly prevalent. Especially, newly born calves have weak lung qi, and the functions of lung dispersing and descending have not been fully established, making them most susceptible. And for preventing and controlling respiratory diseases, enhancing the barrier function of the upper respiratory tract is one of the most effective preventive measures. This composition has the dual effects of enhancing the barrier defense of the upper respiratory tract and clearing the respiratory symptoms caused by external pathogenic factors invading from inside and outside.

[0005] To achieve the above purpose, the present invention provides the following solutions:

[0006] One of the technical solutions of the present invention is a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newly born calves in cold northern regions, which is made of the following components in parts by weight: 16 - 24 parts of Ramulus Cinnamomi, 16 - 24 parts of Radix Paeoniae Alba, 8 - 12 parts of Flos Lonicerae, 8 - 12 parts of Herba Taraxaci, 8 - 12 parts of Fructus Arctii, 8 - 12 parts of Radix Saposhnikoviae, 3 - 7 parts of honey, and 3 - 7 parts of Radix Glycyrrhizae.

[0007] Another technical solution of the present invention is the preparation method of the traditional Chinese veterinary medicine composition, which includes the following steps:

[0008] (1) After weighing Ramulus Cinnamomi, Radix Paeoniae Alba, Flos Lonicerae, Herba Taraxaci, Fructus Arctii, Radix Saposhnikoviae, and Radix Glycyrrhizae according to the ratio, mix and pulverize them.

[0009] (2) Soak the crushed medicinal materials in water, then boil for the first extraction, and filter to obtain the first extract and the medicinal residues.

[0010] (3) Add water to the medicinal residues, boil for the second extraction, and filter to obtain the second extract.

[0011] (4) Combine the first extract and the second extract, add honey, and concentrate to obtain the traditional Chinese veterinary medicine composition.

[0012] The third technical solution of the present invention is a pharmaceutical preparation for preventing respiratory diseases of newly born calves in cold northern regions, including the traditional Chinese veterinary medicine composition.

[0013] Based on the above technical solutions, the present invention has the following technical effects:

[0014] The present invention improves the traditional Yupingfeng Powder by removing raw astragalus membranaceus and adding cinnamon twig and raw white peony root, strengthening the efficacy of improving qi deficiency of the lung, avoiding recurrence of diseases, and will better improve the condition of qi deficiency of the lung in newly born calves, regulating nutrient qi and defensive qi, consolidating defensive qi, tonifying qi and strengthening the spleen, strengthening the healthy qi and consolidating the exterior, and forming a solid upper respiratory tract barrier. At the same time, together with heat-clearing and detoxifying herbs such as honeysuckle and dandelion, and heat-clearing and throat-soothing burdock fruit, and honey guiding the medicine into the lung meridian, licorice regulating the middle energizer and relieving spasm, and harmonizing various herbs, it will further clear the epidemic toxin invading the interior due to the deficiency of lung qi itself, and enhance the ability of the entire respiratory tract to resist external adverse factors. For the respiratory diseases caused by poor ventilation, turbid air, and qi transformation disorder in the cattle shed in winter in the north, which lead to qi movement disorder. Feeding the newly born calves with the traditional Chinese veterinary medicine composition prepared in Example 1 of the present invention for preventing respiratory diseases can reduce the incidence rate by 40%. Using this traditional Chinese veterinary medicine composition to treat the respiratory diseases of newly born calves, compared with the treatment group using cefotaxime sodium alone, the cure rate is increased by 13.6%, and the cure time is reduced by 36.24 h. Detailed implementation manners

[0015] Now, the various exemplary implementation manners of the present invention will be described in detail. In the examples, the methods are all conventional methods unless otherwise specified, and the reagents are all conventional commercially available reagents or reagents prepared by conventional methods unless otherwise specified. This detailed description should not be regarded as a limitation of the present invention, but should be understood as a more detailed description of certain aspects, characteristics, and implementation manners of the present invention.

[0016] It should be understood that the terms described in the present invention are only for describing particular implementation manners and are not used to limit the present invention. In addition, for the numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0017] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although this invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein can also be used in the implementation or testing of this invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to those documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0018] Without departing from the scope or spirit of this invention, various improvements and changes can be made to the specific embodiments of the description of this invention, which are obvious to those skilled in the art. Other embodiments obtained from the description of this invention are obvious to those skilled in the art. The description and examples of this invention are merely exemplary.

[0019] Regarding the use of "comprising", "including", "having", "containing", etc. herein, they are all open-ended terms, meaning including but not limited to.

[0020] The technical solutions described in this invention, unless otherwise specified, are all conventional solutions in the art, and the reagents or raw materials used, unless otherwise specified, are all purchased from commercial channels or have been made public.

[0021] The embodiment of this invention provides a traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newly born calves in cold northern regions, which is made from the following components in parts by weight: 16 - 24 parts of cassia twig, 16 - 24 parts of raw white peony root, 8 - 12 parts of honeysuckle flower, 8 - 12 parts of dandelion, 8 - 12 parts of great burdock achene, 8 - 12 parts of ledebouriella root, 3 - 7 parts of honey and 3 - 7 parts of licorice root.

[0022] In some specific embodiments, it includes the following components in parts by weight: 20 parts of cassia twig, 20 parts of raw white peony root, 10 parts of honeysuckle flower, 10 parts of dandelion, 10 parts of great burdock achene, 10 parts of ledebouriella root, 5 parts of honey and 5 parts of licorice root.

[0023] The embodiment of this invention also provides a preparation method of the traditional Chinese veterinary medicine composition, including the following steps:

[0024] (1) After weighing cassia twig, raw white peony root, honeysuckle flower, dandelion, great burdock achene, ledebouriella root and licorice root according to the proportion, mix and pulverize them;

[0025] (2) Add water to soak the pulverized medicinal materials, then boil for the first extraction, filter, and obtain extract one and medicinal residues;

[0026] (3) Add water to the medicinal residues, boil for the second extraction, filter, and obtain extract two;

[0027] (4) Combine the first extract and the second extract, add honey, and concentrate to obtain the traditional Chinese veterinary medicine composition.

[0028] In some specific embodiments, the conditions for the first extraction are as follows: the weight ratio of the medicinal materials to water is 1:(8 - 12), the soaking time is 2 - 4 hours, and the extraction time is 1 - 3 hours.

[0029] In some specific embodiments, the conditions for the second extraction are as follows: the weight ratio of the medicinal residues to water is 1:(6 - 10), and the extraction time is 1 - 3 hours.

[0030] In some specific embodiments, the concentration method is as follows: concentrate under the conditions of a pressure of -0.03 to -0.08 mpa and a temperature of 60 - 80 °C until the relative density at 20 - 30 °C is 1.08 - 1.25.

[0031] The embodiment of the present invention also provides a pharmaceutical preparation for preventing and treating respiratory diseases of newly born calves in northern cold regions, which includes the traditional Chinese veterinary medicine composition.

[0032] In some specific embodiments, it also includes pharmaceutically acceptable excipients.

[0033] When calves suffer from respiratory diseases, there are 6 common clinical manifestations: coughing, fever, lethargy, increased nasal secretions, loss of appetite, and increased eye secretions. These are all very important indicators for differentiating whether a cow has a respiratory disease and the degree of infection.

[0034] Example 1

[0035] The traditional Chinese veterinary medicine composition includes the following components in parts by weight: 20 parts of cinnamon twig, 20 parts of raw white peony root, 10 parts of honeysuckle flower, 10 parts of dandelion, 10 parts of great burdock achene, 10 parts of ledebouriella root, 5 parts of honey, and 5 parts of licorice root.

[0036] The preparation method is as follows:

[0037] (1) Weigh cinnamon twig, raw white peony root, honeysuckle flower, dandelion, great burdock achene, ledebouriella root, and licorice root according to the proportion, and then mix and pulverize them.

[0038] (2) Add 10 times the weight of water to the pulverized medicinal materials, soak for 3 hours, then boil for the first extraction, with an extraction time of 2 hours, filter to obtain the first extract and the medicinal residues.

[0039] (3) Add 8 times the weight of water to the medicinal residues, boil for the second extraction, with an extraction time of 2 hours, filter to obtain the second extract.

[0040] (4) Combine extract one and extract two, add honey, and concentrate under the conditions of a pressure of -0.05 mpa and a temperature of 70 °C until the relative density at room temperature is 1.2, then the traditional Chinese veterinary medicine composition can be obtained.

[0041] Example 2

[0042] The traditional Chinese veterinary medicine composition includes the following components in parts by weight: 16 parts of cinnamon twig, 16 parts of raw white peony root, 12 parts of honeysuckle flower, 12 parts of dandelion, 8 parts of great burdock achene, 8 parts of ledebouriella root, 7 parts of honey and 7 parts of licorice root.

[0043] The preparation method is as follows:

[0044] (1) Weigh cinnamon twig, raw white peony root, honeysuckle flower, dandelion, great burdock achene, ledebouriella root and licorice root according to the proportion, and then mix and pulverize them;

[0045] (2) Add 10 times the weight of water to the pulverized medicinal materials and soak for 3 hours, then boil for the first extraction, with an extraction time of 2 hours, filter to obtain extract one and medicinal residues;

[0046] (3) Add 8 times the weight of water to the medicinal residues, boil for the second extraction, with an extraction time of 2 hours, filter to obtain extract two;

[0047] (4) Combine extract one and extract two, add honey, and concentrate under the conditions of a pressure of -0.05 mpa and a temperature of 70 °C until the relative density at room temperature is 1.2, then the traditional Chinese veterinary medicine composition can be obtained.

[0048] Example 3

[0049] The traditional Chinese veterinary medicine composition includes the following components in parts by weight: 24 parts of cinnamon twig, 24 parts of raw white peony root, 8 parts of honeysuckle flower, 8 parts of dandelion, 12 parts of great burdock achene, 12 parts of ledebouriella root, 5 parts of honey and 3 parts of licorice root.

[0050] The preparation method is as follows:

[0051] (1) Weigh cinnamon twig, raw white peony root, honeysuckle flower, dandelion, great burdock achene, ledebouriella root and licorice root according to the proportion, and then mix and pulverize them;

[0052] (2) Add 10 times the weight of water to the pulverized medicinal materials and soak for 3 hours, then boil for the first extraction, with an extraction time of 2 hours, filter to obtain extract one and medicinal residues;

[0053] (3) Add 8 times the weight of water to the medicinal residues, boil for the second extraction, with an extraction time of 2 hours, filter to obtain extract two;

[0054] (4) Combine the first extraction liquid and the second extraction liquid, add honey, and concentrate under the conditions of a pressure of -0.05 mpa and a temperature of 70 °C until the relative density at room temperature is 1.2, then the traditional Chinese veterinary medicine composition can be obtained.

[0055] Effect example

[0056] This experiment was carried out in a cattle farm of Fuyida Animal Husbandry Co., Ltd. in Yushu City, Jilin Province. The experiment was selected to be carried out at the beginning of December, with a test period of 30 days and repeated three times.

[0057] Each time, 40 newly born calves with similar birth times and consistent health conditions were selected, randomly divided into a control group and an experimental group, and numbered, with 20 calves in each group. The control group was fed with normal feed, and the experimental group was added with the traditional Chinese veterinary medicine composition prepared in Example 1 (20 g / head, taken every other day) on the basis of the control group for prevention, and the test period was 30 d.

[0058] When calves suffer from respiratory diseases, there are 6 common clinical manifestations: cough, fever, lethargy, increased nasal secretions, decreased appetite, and increased eye secretions. The diagnosis standard of suffering from respiratory diseases is the appearance of any two of these symptoms.

[0059] If calves show symptoms of respiratory diseases during the experiment, the control group is treated by injecting cefotaxime sodium for veterinary use, and the dosage is 5 mg / kg. The experimental group takes the traditional Chinese veterinary medicine composition prepared in Example 1 (40 g / head / day) on the basis of the control group until the dosage during the prevention period is restored after recovery.

[0060] During the test period, the basic diets of each group were exactly the same, and they drank water freely. The prevalence rate, cure rate, and cure time of respiratory diseases of the two groups of calves during the experiment were statistically counted. The results are shown in Table 1.

[0061] Table 1

[0062] Total number Number of diseased Prevalence rate Number of cured Cure rate Average cure time Experimental group 60 17 28.3％ 16 94.1％ 96.44h Control group 60 41 68.3％ 33 80.5％ 132.68h

[0063] As can be seen from Table 1, when the traditional Chinese veterinary medicine composition prepared in Example 1 of the present invention is used to feed newly born calves for preventing respiratory diseases, the incidence rate can be reduced by 40%. When the traditional Chinese veterinary medicine composition is used to treat the respiratory diseases of newly born calves, compared with the treatment group using cefotaxime sodium alone, the cure rate is increased by 13.6%, and the cure time is reduced by 36.24 h.

[0064] In late autumn, early spring and winter in the north, the temperature is low, the temperature difference is large, and the air is dry. In addition, the lung is a delicate organ, which most likes a warm and humid environment and most dislikes cold and dryness. At the same time, the lung qi of newly born calves is still relatively weak, and at this time, they are extremely susceptible to respiratory diseases. The upper respiratory tract is the gateway of the respiratory tract. Using a formula for strengthening the superficial resistance has a good preventive effect; due to the weakness of lung qi, being affected by external pathogens, the cold pathogen directly attacking leads to the weakness of qi movement, the epidemic toxin taking the opportunity to invade, the superficial resistance not being firm, the external pathogens not being removed, and then the interior syndrome of the lung occurs.

[0065] Jade Screen Powder is composed of astragalus membranaceus, atractylodes macrocephala, and ledebouriella seseloides, and has the effects of replenishing qi, strengthening the superficies, and stopping sweating. Clinically, it is used for the syndrome of insecurity of the superficies due to deficiency of the spleen and lung qi. The present invention improves the traditional Jade Screen Powder by removing raw astragalus membranaceus, adding cinnamon twig and raw white peony root, strengthening the efficacy of improving the deficiency of lung qi, avoiding recurrence of diseases, and will preferably improve the condition of deficiency of lung qi in newly born calves, regulating nutrient qi and defensive qi, strengthening the defensive qi, replenishing qi and invigorating the spleen, strengthening the healthy qi and consolidating the superficies, and forming a solid upper respiratory tract barrier effect. At the same time, it is combined with heat-clearing and detoxifying herbs such as honeysuckle and dandelion, and heat-clearing and throat-soothing arctium lappa. Honey is used to introduce the herbs into the lung meridian, and licorice moderates urgency and harmonizes all the herbs, which will further remove the epidemic toxin that enters the interior due to the deficiency of its own lung qi, and enhance the ability of the entire respiratory tract to resist external adverse factors. For the respiratory diseases caused by poor ventilation, turbid air, and qi transformation disorder in the cattle shed in winter in the north, which lead to disharmony of qi movement.

[0066] Obviously, the above-mentioned embodiments of the present invention are only examples for clearly explaining the present invention, and are not intended to limit the implementation manners of the present invention. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. Any modifications, equivalent substitutions, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the claims of the present invention.

Claims

1. A traditional Chinese veterinary medicine composition for preventing and treating respiratory diseases of newborn calves in cold regions in the north, characterized in that, It is made from the following components in parts by weight: 20 parts of Ramulus Cinnamomi, 20 parts of Radix Paeoniae Alba, 10 parts of Flos Lonicerae, 10 parts of Herba Taraxaci, 10 parts of Fructus Arctii, 10 parts of Saposhnikovia divaricata, 5 parts of honey and 5 parts of Radix Glycyrrhizae; Its preparation method comprises the following steps: (1) Weigh Ramulus Cinnamomi, Radix Paeoniae Alba, Flos Lonicerae, Herba Taraxaci, Fructus Arctii, Saposhnikovia divaricata and Radix Glycyrrhizae according to the ratio, and then mix and pulverize them; (2) Add water to the pulverized medicinal materials for soaking, then boil for the first extraction, and filter to obtain the first extract and the medicinal residues; (3) Add water to the medicinal residues, boil for the second extraction, and filter to obtain the second extract; (4) Combine the first extract and the second extract, add honey, and concentrate to obtain the traditional Chinese veterinary medicine composition.

2. The traditional Chinese veterinary medicine composition according to claim 1, wherein the conditions for the first extraction are: the weight ratio of the medicinal materials to water is 1:(8 - 12), the soaking time is 2 - 4 hours, and the extraction time is 1 - 3 hours.

3. The traditional Chinese veterinary medicine composition according to claim 1, wherein the conditions for the second extraction are: the weight ratio of the medicinal residues to water is 1:(6 - 10), and the extraction time is 1 - 3 hours.

4. The traditional Chinese veterinary medicine composition according to claim 1, wherein the concentration method is: concentrate under the conditions of a pressure of -0.03 to -0.08 mpa and a temperature of 60 - 80 °C until the relative density at 20 - 30 °C is 1.08 - 1.

25.

5. A pharmaceutical preparation for preventing and treating respiratory diseases of newly born calves in cold regions of northern China, characterized in that, It includes the traditional Chinese veterinary medicine composition according to claim 1.

6. The pharmaceutical preparation according to claim 5, characterized in that, It further includes pharmaceutically acceptable excipients.