Traditional Chinese medicine composition for treating cerebral apoplexy sequelae and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating cerebral apoplexy sequelae and a preparation method thereof. The traditional Chinese medicine composition comprises an oral part and an external part, wherein the oral part comprises the following components: cissus pteroclada hayata, lindera glauca, cudrania cochinchinensis, ligusticum sinense oliver, rhizoma acori graminei, corallodiscus flabellatus, Chuanminia cochinchinensis, angelica sinensis, ligusticum wallichii, radix paeoniae alba, radix rehmanniae preparata, peach kernel, safflower carthamus, radix cyathulae, teasel root and parasitic loranthus; the external use part comprises the following components: asiatic toddalia root, rhizoma drynariae, herba epimedii, ferula asafetida, Chuanminshen herb, radix zanthoxyli and radix aconiti carmichaeli. Various dysfunctions caused by cerebral apoplexy sequelae are treated by adopting an oral prescription and an external packaging technology, and the traditional Chinese medicine is unique in curative effect, 100% effective, safe, reliable, small in risk and free of toxic and side effects.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and more particularly to a traditional Chinese medicine composition for treating sequelae of cerebral apoplexy and a preparation method thereof. Background Art

[0002] Stroke, also known as cerebral infarction, is characterized by high incidence, high recurrence rate and high mortality rate. Patients with stroke have limb disorders, decreased muscle tone, even zero muscle tone, aphasia, blurred brain consciousness, and even become vegetative state and other sequelae. Stroke is a disease of cerebral blood circulation disorder, which is mainly divided into two categories. One is hemorrhagic stroke, including cerebral hemorrhage and subarachnoid hemorrhage; the other is ischemic stroke, including transient ischemic attack, cerebral thrombosis and cerebral embolism. Among them, the incidence of ischemic stroke is as high as 80%, and it increases with age. The occurrence of ischemic stroke is mainly due to the formation of cerebral embolism and local thrombosis, vascular stenosis and thromboembolism caused by atherosclerosis, or emboli from the heart flowing to the brain with blood to cause cerebral embolism; or vascular damage and vascular inflammation caused by various reasons.

[0003] The main therapeutic principle for ischemic stroke is thrombolysis, relieving vascular obstruction, promoting vascular recanalization, restoring blood supply to the brain, and improving the sequelae of ischemic stroke. The specific methods are drug therapy, surgical treatment and rehabilitation treatment. The effective method for improving the symptoms of sequelae of cerebral stroke, such as hemiplegia, is mainly to combine scientific diet and active and passive recovery exercises with drug therapy. It can not only effectively treat the basic lesions such as atherosclerotic plaque formation and high blood viscosity that induce cerebral stroke, thereby preventing the re-formation of arteriosclerotic thrombus; it can also improve the blood and oxygen supply to the brain tissue, create a good internal environment for the brain tissue, restore the brain nervous system, and thus improve the motor and language nervous system signs controlled by it. However, the current related Chinese medicine compositions have problems such as poor therapeutic effect and long course of treatment.

[0004] Therefore, providing a safe and reliable Chinese medicine composition for treating stroke sequelae, which has no toxic side effects and a short treatment course, and a preparation method thereof is a problem that needs to be solved by those skilled in the art. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a Chinese medicine composition for treating sequelae of stroke and a preparation method thereof. The present invention adopts oral prescriptions, external prescription packaging and other technologies to treat various functional disorders caused by sequelae of stroke, with unique efficacy, 100% effectiveness, safety and reliability, low risk, and no toxic side effects.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] A Chinese medicine composition for treating sequelae of stroke, comprising an oral part and an external part;

[0008] Wherein, the oral part includes the following components:

[0009] Four-sided vine, magufeng, chuanposhi, ligusticum, calamus, stone gall, chuanshicao, angelica, chuanxiong, white peony root, prepared rehmannia, peach kernel, safflower, chuanxiong, diatom and mistletoe;

[0010] The external use part includes the following components:

[0011] Feilong Palm Blood, Drynaria fortunei, Epimedium, Ferula, Cyathula capitata, Zanthoxylum bungeana and Aconitum.

[0012] The oral prescription of the composition of the present invention mainly calms the liver and relieves wind, removes blood stasis and dredges the collaterals, and is supplemented by strengthening the body and removing evil, invigorating qi and activating blood circulation, so as to achieve the purpose of removing evil and restoring the body; the four-cornered vine, the magus rotundus, the scutellaria baicalensis and the radix ligusticum are the main drugs, which are mainly used to dispel wind and dampness, activate blood circulation and dredge the collaterals; the ministerial drugs: the calamus, the gallbladder, the scutellaria baicalensis, the angelica, the ligusticum chuanxiong, the white peony root and the rehmannia glutinosa can activate blood circulation and promote qi, dispel wind and relieve pain, and play an auxiliary therapeutic effect; the adjuvant drugs: the peach kernel, the safflower and the cyathula can activate blood circulation and remove blood stasis, remove blood stasis and dredge the collaterals, and play a supporting role; the guiding drugs: the radix dipsaci and the viburnum parasiticum can dredge the meridians and regulate blood circulation, and play a guiding and harmonizing role, and the monarch, the ministerial, the adjuvant and the guiding drugs have synergistic effects.

[0013] The external prescriptions are mainly used to warm the kidney and strengthen yang, dispel wind and disperse blood stasis, supplemented by promoting blood circulation and removing blood stasis, removing dampness and reducing swelling, so as to achieve the purpose of warming the meridians and unblocking the vessels. Feilong Zhangxue, Gusuanbu, and Yinyanghuo are the main drugs, which are mainly used to nourish the kidney and strengthen yang, promote qi and activate blood circulation. The minister drug: Asafoetida disperses the knot, which plays an auxiliary therapeutic role. The adjuvant drug: Chuanshicao and Liangmianzhen removes dampness and reduces swelling, which plays a supporting role. The messenger drug: Fuzi plays a role in warming the meridians and harmonizing. The monarch, minister, assistant and messenger drugs work synergistically.

[0014] Preferably, it comprises an oral part and an external part;

[0015] Wherein, the oral part includes the following components by weight:

[0016] 15 parts of scutellaria baicalensis, 15 parts of rhizoma scutellariae, 15 parts of rhizoma lisianthus, 10 parts of calamus, 10 parts of scutellariae, 10 parts of scutellariae, 10 parts of angelica, 10 parts of ligusticum, 10 parts of rhizoma chuanxiong, 10 parts of white peony root, 10 parts of rehmannia glutinosa, 10 parts of peach kernel, 10 parts of safflower, 10 parts of cyathulae, 10 parts of dipsacus and 10 parts of parasitic plant; each component can float 20%;

[0017] The external use part includes the following components in parts by weight:

[0018] 3 parts of Flying Dragon Palm Blood, 3 parts of Drynaria Bge, 3 parts of Epimedium, 3 parts of Ferula Asafoetida, 3 parts of Cyathula capitata, 3 parts of Zanthoxylum bungeanum and 3 parts of Aconitum; each component can float 30%.

[0019] According to the different symptoms of stroke, it is divided into 4 symptom categories and corresponding components are added to the oral part, which are:

[0020] (1) Wind and Yang disturbance

[0021] Clinical manifestations: hemiplegia, numbness of the skin, crooked mouth and tongue, slurred speech, or stiff tongue, irritability, headache, dizziness, red face and eyes, bitter mouth and dry throat; red urine and dry stool; red tongue with little or yellow coating, stringy and rapid pulse;

[0022] Therapeutic Method: Clear the liver and purge fire, calm the wind and suppress yang;

[0023] Prescription: For the oral part of the composition, add 10 parts of Uncaria rhynchophylla, 10 parts of Gardenia jasminoides, 10 parts of Paeonia suffruticosa, and 10 parts of Morus alba; each component can float by 20%.

[0024] For external use: Same as the basic formula above.

[0025] (2) Wind and phlegm blocking the collaterals

[0026] Clinical manifestations: numbness of the skin, even hemiplegia, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dizziness; dark tongue with white and greasy coating, and a stringy and slippery pulse;

[0027] Therapeutic method: calming wind and resolving phlegm, activating blood circulation and unblocking meridians;

[0028] Prescription: For the oral part of the composition, add 10 parts of Pinellia, 10 parts of Atractylodes, 10 parts of Arisaema and 10 parts of Astragalus; each component can be floated by 20%.

[0029] For external use: Same as the basic formula above.

[0030] (3) Phlegm-heat and bowel-retention

[0031] Clinical manifestations: hemiplegia, numbness of the skin, crooked mouth and tongue; difficulty speaking or slurred speech; dizziness, spitting or excessive sputum, abdominal distension, dry stool or constipation; dark red or pale tongue, yellow or greasy tongue coating, stringy or rapid pulse;

[0032] Therapeutic method: Clear away heat and resolve phlegm, clear the bowels and expel turbidity;

[0033] Prescription: For the oral part of the composition, add 10 parts of Trichosanthes kirilowii, 10 parts of Ophiopogon japonicus, 10 parts of Polygonum multiflorum and 10 parts of Gastrodia elata; each component can be floated by 20%.

[0034] For external use: Same as the basic formula above.

[0035] (4) Qi deficiency and blood stasis

[0036] Clinical manifestations: hemiplegia, numbness of the skin, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dull complexion, shortness of breath and fatigue; drooling from the corners of the mouth, spontaneous sweating, palpitations, loose stools; swelling of the hands, feet or one side of the body; dark or ecchymotic tongue, thin white or greasy tongue coating, deep, weak, slow or astringent pulse;

[0037] Treatment method: replenish qi and strengthen the body, activate blood circulation and remove blood stasis;

[0038] Prescription: For the oral part of the composition, add 10 parts of Astragalus, 10 parts of Codonopsis, 10 parts of Hirudo and 10 parts of Lycopodiella ciliata; each component can float 20%.

[0039] For external use: Same as the basic formula above.

[0040] The usage of the above prescription is: for the oral part, one dose per day, decoct each dose twice, take it in the morning and evening; for the external part, one dose per day, divide each dose of ointment into three portions, apply it evenly on three gauze pieces, stick the gauze pieces coated with the sealed medicine on the Neiguan acupoint and Yongquan acupoint on the affected side and the Yongquan acupoint on the healthy side of the patient respectively, fix them with bandages, pour hot water at about 45°C into the hand and foot bath bucket, the amount of water for hand bathing on the upper limbs should be enough to submerge the Quchi acupoint, and the amount of water for both lower limbs should be enough to submerge the Zusanli acupoint, the hand and foot bathing time is 30 minutes, and it can float up and down for 10 minutes, and the temperature fluctuates up and down by 5°C.

[0041] All patients with post-stroke sequelae are treated according to stages and courses. Two courses (15 doses for one course) are one stage. At the end of the first course, the patient has obvious symptom relief and functional improvement, and can continue the second stage of treatment. At the end of the two stages of treatment, the function is improved. In the first course, the basic prescription and external prescription are taken, and in the second and third courses, various types of modified prescriptions and external prescriptions are taken.

[0042] The method for preparing the above-mentioned Chinese medicine composition for treating sequelae of stroke comprises the following specific steps:

[0043] (1) weighing the raw materials of the oral portion and the external portion according to weight and setting aside;

[0044] (2) Mix all the raw materials of the oral part, soak them in cold water, boil them in boiling water for 30-60 minutes, and filter them to obtain the medicinal juice, wherein the medicinal juice is controlled to be 200-300 ml;

[0045] (3) The raw materials of the external application part are crushed to obtain a powder, and alcohol is added to the powder to prepare an external application ointment.

[0046] Preferably, the cold water immersion time in step (2) is 2 hours, and the water is sufficient to immerse the medicine.

[0047] Preferably, the mass volume ratio of the medicinal powder and the alcohol in step (3) is: 21g:100ml.

[0048] It can be seen from the above technical solutions that, compared with the prior art, the present invention has the following technical effects:

[0049] (1) The Chinese medicine composition of the present invention can assist in the treatment of classical traditional acupuncture, bloodletting therapy, hemiplegia comprehensive training and the like, restore the function of some of the patient's nerve cells, and gradually restore the lost motor function, speech function, swallowing function, etc., without any effect on other organs of the body, and can enhance the patient's confidence in life, improve appetite, improve sleep, improve quality of life, and promote health.

[0050] (2) The Chinese medicine composition of the present invention has a rapid onset of effect, is safe and effective, and strictly follows the drug compatibility, and the addition and subtraction of drugs does not violate the "Eighteen Antidotes" and "Nineteen Fears", and the drug dosage ratio is safe. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. The drawings in this description are only embodiments of the present invention.

[0052] Figure 1 This is the CT examination result diagram of case 1 before treatment of the present invention; Figure 2 This is the CT examination result after treatment of case 1 of the present invention; Figure 3 This is the CT examination result before treatment of case 2 of the present invention; Figure 4 This is the CT examination result after treatment of case 2 of the present invention; Figure 5 This is the CT examination result before treatment of case 3 of the present invention; Figure 6 This is the CT examination result after treatment of case 3 of the present invention; Figure 7 This is the CT examination result of case 4 before treatment of the present invention; Figure 8 This is the CT examination result after treatment of case 4 of the present invention;

[0053] Fig. 9 This is the CT examination result before treatment of case 5 of the present invention; Fig.10 This is the CT examination result after treatment of case 5 of the present invention; Fig.11 This is the CT examination result before treatment of case 6 of the present invention; Fig.12 This is the CT examination result after treatment of case 6 of the present invention; Fig.13 This is the CT examination result of case 7 before treatment of the present invention; Fig.14 This is the CT examination result after treatment of case 7 of the present invention; Fig.15 This is the CT examination result before treatment of case 8 of the present invention; Fig.16This is the CT examination result after treatment of case 8 of the present invention; Fig.17 This is the CT examination result of case nine before treatment of the present invention; Fig.18 This is the CT examination result after treatment of case nine of the present invention; Fig.19 This is the CT examination result diagram of case 10 before treatment of the present invention;

[0054] Fig. 20 This is a CT examination result diagram of case 10 after treatment of the present invention. DETAILED DESCRIPTION

[0055] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0056] Example 1

[0057] A method for preparing a Chinese medicine composition for treating sequelae of stroke, specifically comprising the following steps:

[0058] (1) Weigh the raw materials for oral administration: 15 g of Rhizoma Cynoglossi, 15 g of Rhizoma Glehniae, 15 g of Rhizoma Ligustici, 10 g of Rhizoma Acorus, 10 g of Rhizoma Glehniae, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Angelicae Sinensis, 10 g of Rhizoma Chuanxiong, 10 g of Rhizoma Paeoniae Alba, 10 g of Rhizoma Rehmanniae Preparata, 10 g of Rhizoma Prunellae, 10 g of Rhizoma Carthamus, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Dipsaci, and 10 g of Rhizoma Parasitica, for a total of 15 doses, and set aside;

[0059] (2) Oral administration of the raw materials is one dose per day, taken twice a day, morning and evening. The specific preparation method is as follows: in the morning, put one dose of raw materials into a decoction pot and soak in cold water for 2 hours, the water should be enough to immerse the medicine, light a fire after 2 hours, and control the decoction time to 30-60 minutes after the water boils, and control the medicine juice to 200-300 ml. After the decoction juice in the decoction pot is filtered out and taken, the filter residue is kept until the afternoon, and then put into 400 ml of clean water and decoct for another 30-60 minutes until the medicine juice is 200-300 ml, and then filter it out and take it;

[0060] (3) Weigh 3 g of the raw materials for external use, including 3 g of Flying Dragon Palm Blood, 3 g of Drynaria, 3 g of Epimedium, 3 g of Ferula, 3 g of Herba Cynoglossi, 3 g of Zanthoxylum bungeana, 3 g of Zanthoxylum bungeana, and 3 g of Radix Aconiti Lateralis, for a total of 15 doses. Pour the raw materials for external use, either alone or in combination, into a Chinese medicine powder grinder (crushed to 300 meshes) and pour into a medicine storage barrel, seal and stir evenly. Pour 100 ml of 75% alcohol into a medicine mixing bowl, add 21 g of the powder and stir evenly with an appropriate amount of purified water. Prepare a wet compress ointment and then divide it into three portions. Stick the gauze coated with the medicine on the Neiguan acupoint and Yongquan acupoint on the affected side and the healthy side of the patient respectively and secure them with a bandage. Pour hot water at about 45°C into the hand and foot bath bucket. The amount of water for hand bathing of the upper limbs should be enough to submerge the Quchi acupoint, and the amount of water for both lower limbs should be enough to submerge the Zusanli acupoint. The hand and foot bathing time is 30 minutes, and the temperature can fluctuate up and down for 10 minutes. The temperature fluctuates up and down by 5°C.

[0061] Example 2

[0062] A method for preparing a Chinese medicine composition for treating sequelae of stroke, specifically comprising the following steps:

[0063] (1) Weigh the raw materials for oral administration: 15 g of Rhizoma Sifangii, 15 g of Rhizoma Magufeng, 15 g of Rhizoma Chuanpodis, 15 g of Rhizoma Ligustici, 10 g of Rhizoma Acorus, 10 g of Rhizoma Ligustici, 10 g of Rhizoma Chuanxiong, 10 g of Rhizoma Paeoniae Alba, 10 g of Rhizoma Rehmanniae Preparata, 10 g of Rhizoma Pruni, 10 g of Rhizoma Carthami, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Dipsaci, 10 g of Rhizoma Viscum, 10 g of Rhizoma Uncariae, 10 g of Rhizoma Gardeniae, 10 g of Rhizoma Moutan and 10 g of Folium Mori. Take 15 doses in total and set aside.

[0064] The remaining steps are the same as steps (2) and (3) of the embodiment.

[0065] Example 3

[0066] A method for preparing a Chinese medicine composition for treating sequelae of stroke, specifically comprising the following steps:

[0067] (1) Weigh the raw materials for oral administration: 15 g of Rhizoma Sifangii, 15 g of Rhizoma Magufeng, 15 g of Rhizoma Chuanpodis, 15 g of Rhizoma Ligustici, 10 g of Rhizoma Acorus, 10 g of Rhizoma Ligustici, 10 g of Rhizoma Chuanxiong, 10 g of Rhizoma Paeoniae Alba, 10 g of Rhizoma Rehmanniae Preparata, 10 g of Rhizoma Prunellae, 10 g of Rhizoma Carthamus, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Dipsaci, 10 g of Rhizoma Mori, 10 g of Rhizoma Pinelliae, 10 g of Rhizoma Atractylodis Macrocephalae, 10 g of Rhizoma Arisaematis, and 10 g of Radix Astragali. Take 15 doses in total and set aside.

[0068] The remaining steps are the same as steps (2) and (3) of the embodiment.

[0069] Example 4

[0070] A method for preparing a Chinese medicine composition for treating sequelae of stroke, specifically comprising the following steps:

[0071] (1) Weigh the raw materials for oral administration: 15 g of Rhizoma Sifangii, 15 g of Rhizoma Magufeng, 15 g of Rhizoma Chuanpodis, 15 g of Rhizoma Ligustici, 10 g of Rhizoma Acorus, 10 g of Rhizoma Ligustici, 10 g of Rhizoma Chuanxiong, 10 g of Rhizoma Paeoniae Alba, 10 g of Rhizoma Rehmanniae Preparata, 10 g of Rhizoma Prunellae, 10 g of Rhizoma Carthamus, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Dipsaci, 10 g of Rhizoma Viscum, 10 g of Rhizoma Trichosanthis, 10 g of Rhizoma Ophiopogonis, 10 g of Rhizoma Polygoni Multiflori, and 10 g of Rhizoma Gastrodiae, for a total of 15 doses, and set aside;

[0072] The remaining steps are the same as steps (2) and (3) of the embodiment.

[0073] Example 5

[0074] A method for preparing a Chinese medicine composition for treating sequelae of stroke, specifically comprising the following steps:

[0075] (1) Weigh the raw materials for oral administration: 15 g of Rhizoma Sifangii, 15 g of Rhizoma Magufeng, 15 g of Rhizoma Chuanpodis, 15 g of Rhizoma Ligustici, 10 g of Rhizoma Acorus, 10 g of Rhizoma Ligustici, 10 g of Rhizoma Chuanxiong, 10 g of Rhizoma Paeoniae Alba, 10 g of Rhizoma Rehmanniae Preparata, 10 g of Rhizoma Prunellae, 10 g of Rhizoma Carthamus, 10 g of Rhizoma Cynoglossi, 10 g of Rhizoma Dipsaci, 10 g of Rhizoma Mori, 10 g of Rhizoma Astragali, 10 g of Rhizoma Codonopsis, 10 g of Rhizoma Hirudo and 10 g of Rhizoma Dioscoreae, a total of 15 doses, set aside;

[0076] The remaining steps are the same as steps (2) and (3) of the embodiment.

[0077] Clinical Trials

[0078] Case 1

[0079] Chen, female, 47 years old;

[0080] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue, slurred speech, or stiff tongue, irritability, headache, dizziness, flushed face and eyes, bitter mouth and dry throat, dark urine, dry stool, red tongue with little or yellow coating, stringy and rapid pulse;

[0081] Diagnosis: sequelae of stroke caused by disturbance of wind-yang;

[0082] Treatment method: clearing the liver and purging fire, calming wind and suppressing yang; using the Chinese medicine composition of Example 1;

[0083] Before treatment: At the time of admission (April 26, 2024), he was conscious but mentally depressed. He was carried into the ward with left limb dysfunction, hemiplegia, crooked mouth, slurred speech, and was unable to take care of himself. CT records showed that the right thalamic hemorrhage and rupture of the ventricular system were improving. Figure 1 As shown;

[0084] On April 26, 2024, the patient was treated in our hospital using the Chinese medicine composition of Example 1. The CT examination results on May 23, 27 days after treatment, showed that the right thalamic hemorrhage and rupture of the ventricular system were better absorbed after treatment. Figure 2 ;

[0085] After continuing to take the medication for 3 days, he completed 2 courses of treatment and was basically cured and discharged from the hospital. Now he can take care of himself and walk freely. Although he cannot participate in productive labor, his living condition is good.

[0086] Case 2

[0087] Fang, male, 55 years old;

[0088] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue, slurred speech, or stiff tongue, irritability, headache, dizziness, flushed face and eyes, bitter mouth and dry throat, dark urine, dry stool, red tongue with little or yellow coating, stringy and rapid pulse;

[0089] Diagnosis: Stroke caused by disturbance of wind-yang;

[0090] Treatment method: clearing the liver and purging fire, calming wind and suppressing yang; using the Chinese medicine composition of Example 1;

[0091] Before treatment: At the time of admission (April 26, 2024), he was unconscious, with an acute appearance, and was carried into the ward. He had no muscle tension in his limbs, especially on the right side, and his mouth was crooked and drooling. The CT recording results showed left thalamic hemorrhage (rupture of the ventricular system). Figure 3 As shown;

[0092] On October 16, 2024, the patient was treated in our hospital using the Chinese medicine composition of Example 1. After 20 days of treatment, the CT recording results showed that the right thalamic hemorrhage and rupture of the ventricular system were absorbed better after treatment. Figure 4 ;

[0093] After 10 days of medication, 2 courses of treatment were completed, the patient was conscious, energetic, emotionally stable, and discharged from the hospital. However, he is still unable to take care of himself, has right hemiplegia, slurred speech, no crooked mouth, muscle tension level 3, and muscle strength level 2, and still needs to continue rehabilitation treatment.

[0094] Case 3

[0095] Zhang, male, 68 years old;

[0096] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue, slurred speech, or stiff tongue, irritability, headache, dizziness, flushed face and eyes, bitter mouth and dry throat, dark urine, dry stool, red tongue with little or yellow coating, stringy and rapid pulse;

[0097] Diagnosis: sequelae of stroke caused by disturbance of wind-yang;

[0098] Treatment method: clear the liver and purge fire, calm the wind and suppress yang; use the Chinese medicine composition of Example 2;

[0099] Before treatment: At the time of admission (November 27, 2023), he was conscious, mentally depressed, irritable, aphasic, unable to stand, with a chronic illness, carried into the ward, right limb muscle tension was level 0, muscle strength was level 0, left muscle tension was level 4, muscle strength was level 3, corners of mouth were crooked, CT records showed large softening lesions in the left brain, such as Figure 5 As shown;

[0100] On November 27, 2023, the patient was treated in our hospital using the Chinese medicine composition of Example 2. After nearly one year of treatment, the CT recording results showed that the left brain lesion was basically stable. Figure 6 ;

[0101] The patient's family was very satisfied with the treatment effect and has been taking this prescription. After 350 days of use, he completed multiple courses of treatment intermittently. He is conscious, energetic, well-behaved, can communicate in single words, can walk, has stable blood pressure, can be supported into the ward, the muscle tone of the right limbs is level 4, the muscle strength is level 3, the muscle tone of the left side is level 5, the muscle strength is level 4, and there is no crookedness at the corners of the mouth.

[0102] Case 4

[0103] Li, male, 50 years old;

[0104] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue, slurred speech, or stiff tongue, irritability, headache, dizziness, flushed face and eyes, bitter mouth and dry throat, dark urine, dry stool, red tongue with little or yellow coating, stringy and rapid pulse;

[0105] Diagnosis: sequelae of stroke caused by disturbance of wind-yang;

[0106] Treatment method: clear the liver and purge fire, calm the wind and suppress yang; use the Chinese medicine composition of Example 2;

[0107] Before treatment: At the time of admission (July 16, 2024), the patient was conscious, listless, bad-tempered, slurred, able to stand and walk, with dragging of the right lower limb, adduction spasticity of the right upper limb, incomplete right hemiplegia, chronic disease, and was helped into the ward. The muscle tone of the right lower limb was level 4, the muscle strength was level 3, the muscle tone of the right upper limb was level 3, the muscle strength was level 2, the corner of the mouth was crooked, and the CT recording results showed a long low-density softening lesion in the external capsule area of ​​the left basal ganglia, such as Figure 7 As shown;

[0108] On July 16, 2024, the patient was treated in this hospital using the Chinese medicine composition of Example 2. After 40 days of treatment, the CT recording results showed that there were long lamellar low-density softening lesions in the left cerebral basal ganglia, and the lesions were basically stable. Figure 8 ;

[0109] After taking this prescription for 60 days and completing 2 stages and 4 courses of treatment, the patient became conscious, energetic, well-behaved, could communicate smoothly, could walk, the dragging of the right lower limb was relieved, the adduction spasm of the right upper limb was improved, the muscle tone of the right lower limb was level 4+, the muscle strength was level 3+, the muscle tone of the right upper limb was level 3+, and the muscle strength was level 2+.

[0110] Case 5

[0111] Li, male, 41 years old;

[0112] Clinical symptoms: numbness of the skin, even hemiplegia, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dizziness; dark tongue with white and greasy coating, and a stringy and slippery pulse;

[0113] Diagnosis: sequelae of stroke caused by wind-phlegm blocking the collaterals;

[0114] Treatment method: calming wind and resolving phlegm, promoting blood circulation and unblocking collaterals; using the Chinese medicine composition of Example 3;

[0115] Before treatment: At the time of admission (January 2, 2024), the patient was conscious, mentally poor, sluggish, unable to speak, unable to stand, right upper limb adduction spasm, right hemiplegia, chronic condition, carried into the ward, right lower limb muscle tension was level 3, muscle strength level 1, right upper limb muscle tension was level 4, muscle strength level 3, crooked mouth and drooling, CT recording results showed large softening lesions in the left frontal and parietal lobes of the brain, such as Fig. 9 As shown;

[0116] On January 2, 2024, the patient was treated in our hospital using the Chinese medicine composition of Example 3. After more than 7 months of treatment, the CT recording results showed a large patch of softening lesions in the left brain, and the lesions were stable. Fig.10 ;

[0117] The patient's family was very satisfied with the treatment effect. They have been taking this prescription for more than 7 times and have completed multiple courses of treatment. The patient is now conscious, energetic, rosy-cheeked, full of confidence in life, able to communicate in single words, able to walk, and able to enter the ward. The muscle tone of the right lower limb is level 4, and the muscle strength is level 3. The muscle tone of the right upper limb is level 4+, and the muscle strength is level 3+. There is no crookedness or drooling at the corners of the mouth.

[0118] Case 6

[0119] Chen, male, 56 years old;

[0120] Clinical symptoms: numbness of the skin, even hemiplegia, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dizziness; dark tongue with white and greasy coating, and a stringy and slippery pulse;

[0121] Diagnosis: sequelae of stroke caused by wind-phlegm blocking the collaterals;

[0122] Treatment method: calming wind and resolving phlegm, promoting blood circulation and unblocking collaterals; using the Chinese medicine composition of Example 3;

[0123] Before treatment: At the time of admission (April 14, 2024), the patient was conscious, mentally ill, speech was poor, communication was limited, standing was unstable, left upper limb adduction spasticity, left lower limb had difficulty moving and equinovarus, left incomplete hemiplegia, chronic condition, carried into the ward, left lower limb muscle tension was level 3, muscle strength was level 1, right upper limb muscle tension was level 5, muscle strength was level 4, the corners of the mouth were not crooked and there was no drooling, and the CT record results showed a large softening lesion in the right brain, such as Fig.11 As shown;

[0124] On April 14, 2024, the patient was treated in our hospital using the Chinese medicine composition of Example 3. After 10 days of treatment, the CT recording results showed a large patch of softening lesions in the right brain, such as Fig.12 ;

[0125] The patient took this prescription for 10 days, and the effect was obvious before completing one course of treatment; the patient was conscious, in better spirits, confident in life, able to pronounce single words, communication improved, able to stand, the muscle tone of the left lower limb was level 3, and the muscle strength was level 2, the muscle tone of the right upper limb was level 5, and the muscle strength was level 4, the corners of the mouth were not crooked and there was no drooling, and the CT records showed a large softening lesion in the right brain.

[0126] Case 7

[0127] Liu, male, 57 years old;

[0128] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue; slurred speech or slurred speech; dizziness, spitting or excessive sputum, abdominal distension, dry stool or constipation; dark red or pale tongue, yellow or greasy tongue coating, and stringy or rapid pulse.

[0129] Diagnosis: sequelae of stroke caused by phlegm-heat and bowel fullness;

[0130] Treatment method: clearing away heat and resolving phlegm, clearing the bowels and purging turbidity; using the Chinese medicine composition of Example 4;

[0131] Before treatment: At the time of admission (November 17, 2023), he was conscious but in poor spirits, had difficulty speaking, limited communication, had adduction spasticity of the left upper limb, had difficulty moving his left lower limb, had incomplete left hemiplegia, was helped into the ward, had muscle tension of level 3 and strength of level 2 in the left lower limb, had muscle tension of level 5 and strength of level 4 in the right upper limb, had crooked corners of the mouth and no drooling, and CT records showed cerebral infarction in the right basal ganglia. Fig.13 As shown;

[0132] On November 17, 2023, the patient was treated in our hospital using the Chinese medicine composition of Example 4. After one full year of treatment, the CT recording results showed small flakes of softening lesions in the right cerebral basal ganglia, and the lesions were stable. Fig.14 ;

[0133] The patient's family was very satisfied with the therapeutic effect. After taking this prescription for 365 days, the patient completed multiple courses of treatment intermittently. He was conscious, energetic, his speech was restored, his communication was normal, the degree of adduction spasm of the left upper limb was significantly reduced, and his left lower limb could move powerfully. When he entered the ward, the muscle tone of the left lower limb was level 4+ and the muscle strength was level 4. The muscle tone of the right upper limb was level 5 and the muscle strength was level 5. The corners of his mouth were not crooked and there was no drooling, but his gait had not recovered normally.

[0134] Case 8

[0135] Pan, male, 57 years old;

[0136] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue; difficulty speaking or slurred speech; dizziness, spitting or excessive sputum, abdominal distension, dry stool or constipation; dark red or pale tongue, yellow or greasy tongue coating, stringy or rapid pulse;

[0137] Diagnosis: sequelae of stroke caused by phlegm-heat and bowel fullness;

[0138] Treatment method: clearing away heat and resolving phlegm, clearing the bowels and purging turbidity; using the Chinese medicine composition of Example 4;

[0139] Before treatment: At the time of admission (November 15, 2023), the patient was conscious, listless, depressed, had difficulty speaking, had limited communication, had adduction spasticity of the left upper limb, had difficulty moving the left lower limb, had incomplete hemiplegia on the left side, was helped into the ward, had muscle tone of the left lower limb of grade 3, strength of grade 2+, had muscle tone of the right upper limb of grade 5, strength of grade 4, had crooked corners of the mouth and no drooling, and CT records showed cerebral infarction in the right basal ganglia area. Fig.15 As shown;

[0140] On November 15, 2023, the patient was treated in this hospital using the Chinese medicine composition of Example 4. After more than 10 months of treatment, the CT recording results showed patchy softening lesions in the right thalamus, and the lesions were stable. Fig.16 ;

[0141] The patient's family was very satisfied with the therapeutic effect. After taking this prescription for 310 days, the patient completed multiple courses of treatment intermittently. He was conscious, energetic, his speech was restored, his communication was normal, the degree of adduction spasm of the left upper limb was significantly reduced, and his left lower limb could move powerfully. When he entered the ward, the muscle tone of the left lower limb was level 5, and the muscle strength was level 4+. The muscle tone of the right upper limb was level 5, and the muscle strength was level 4+. The corners of his mouth were not crooked and there was no drooling. His gait had basically returned to normal, and the intended movements of his left upper limb were inaccurate.

[0142] Case 9

[0143] Yang, male, 57 years old;

[0144] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dull complexion, shortness of breath and fatigue; drooling from the corners of the mouth, spontaneous sweating, palpitations, loose stools; swelling of the hands, feet or one side of the body; dark or ecchymotic tongue, thin white or greasy tongue coating, deep, weak, slow or astringent pulse;

[0145] Diagnosis: sequelae of stroke caused by qi deficiency and blood stasis;

[0146] Treatment method: replenishing qi and strengthening the body, promoting blood circulation and removing blood stasis; using the Chinese medicine composition of Example 5;

[0147] Before treatment: At the time of admission (November 2, 2023), he was conscious, listless, depressed, speech impeded, communication limited, bilateral limb function limited, especially left incomplete hemiplegia, and was supported into the ward with crutches. The muscle tone of the left lower limb was level 3, the muscle strength was level 2+, the muscle tone of the right upper limb was level 4, the muscle strength was level 3, the corners of the mouth were crooked and there was no drooling. The CT recording results showed cavities in the basal ganglia of the brain on both sides, such as Fig.17 As shown;

[0148] On November 2, 2023, the patient was treated in this hospital using the Chinese medicine composition of Example 5. After 372 days of treatment, the CT recording results showed softening lesions in the right thalamus and left cerebral basal ganglia, and the lesions were stable. Fig.18 ;

[0149] The patient's family was very satisfied with the therapeutic effect. After taking this prescription for 372 days, he completed multiple courses of treatment intermittently. He was conscious, energetic, his speech was restored, his communication was normal, his limbs could move powerfully, he discarded his crutches, and walked into the ward. The muscle tone of the left limb was level 4+, and the muscle strength was level 4+. The muscle tone of the right limb was level 5, and the muscle strength was level 4. The corners of his mouth were not crooked and he did not drool. His gait basically returned to normal, and the intended movements of the left limb were inaccurate.

[0150] Case 10

[0151] Liu, male, 60 years old;

[0152] Clinical symptoms: hemiplegia, numbness of the skin, crooked mouth and tongue; difficulty speaking, or slurred speech or silence; dull complexion, shortness of breath and fatigue; drooling from the corners of the mouth, spontaneous sweating, palpitations, loose stools; swelling of the hands, feet or one side of the body; dark or ecchymotic tongue, thin white or greasy tongue coating, deep, weak, slow or astringent pulse;

[0153] Diagnosis: sequelae of stroke caused by qi deficiency and blood stasis;

[0154] Treatment method: replenishing qi and strengthening the body, promoting blood circulation and removing blood stasis; using the Chinese medicine composition of Example 5;

[0155] Before treatment: At the time of admission (March 25, 2024), he was conscious, in poor spirits, had difficulty speaking, could communicate, had limited right limb function, incomplete right hemiplegia, was supported into the ward with a single crutch, right lower limb muscle tension was level 4, muscle strength level 3, left limb muscle tension was level 5, muscle strength level 4+, crooked mouth corners without drooling, CT records showed old cavity infarction in the left cerebral basal ganglia, such as Fig.19 As shown;

[0156] On March 25, 2024, the patient was treated in our hospital using the Chinese medicine composition of Example 5. After 140 days of treatment, the CT recording results showed old lacunar infarction in the right thalamus and left basal ganglia, and the lesions were stable. Fig. 20 ;

[0157] The patient's family was very satisfied with the therapeutic effect. After taking this prescription for 140 days, the patient completed multiple courses of treatment intermittently. He was conscious, energetic, fluent in speech, normal in communication, and had strong limbs. He discarded his crutches and walked into the ward. The muscle tone of his right lower limb was level 5, and the muscle strength was level 3+. The muscle tone of his left limb was level 5, and the muscle strength was level 5. There was no crookedness or drooling at the corners of his mouth.

[0158] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0159] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Chinese medicine composition for treating sequelae of stroke, characterized in that: It includes oral part and external part; Wherein, the oral part includes the following components: Four-sided vine, magufeng, chuanposhi, ligusticum, calamus, stone gall, chuanshicao, angelica, chuanxiong, white peony root, prepared rehmannia, peach kernel, safflower, chuanxiong, diatom and mistletoe; The external use part includes the following components: Feilong Palm Blood, Drynaria fortunei, Epimedium, Ferula, Cyathula capitata, Zanthoxylum bungeana and Aconitum.

2. A Chinese medicine composition for treating sequelae of stroke according to claim 1, characterized in that: It includes oral part and external part; Wherein, the oral part includes the following components by weight: 15 parts of scutellaria baicalensis, 15 parts of rhizoma scutellariae, 15 parts of rhizoma lisianthus, 10 parts of calamus, 10 parts of scutellariae, 10 parts of scutellariae, 10 parts of angelica, 10 parts of ligusticum, 10 parts of rhizoma chuanxiong, 10 parts of white peony root, 10 parts of rehmannia glutinosa, 10 parts of peach kernel, 10 parts of safflower, 10 parts of cyathulae, 10 parts of dipsacus and 10 parts of parasitic plant; each component can float 20%; The external use part includes the following components in parts by weight: 3 parts of Flying Dragon Palm Blood, 3 parts of Drynaria Bge, 3 parts of Epimedium, 3 parts of Ferula Asafoetida, 3 parts of Cyathula capitata, 3 parts of Zanthoxylum bungeanum and 3 parts of Aconitum; each component can float 30%.

3. A Chinese medicine composition for treating sequelae of stroke according to claim 1, characterized in that: It includes oral part and external part; Wherein, the oral part includes the following components by weight: 15 parts of scutellaria baicalensis, 15 parts of rhizoma scutellariae, 15 parts of rhizoma lisianthus, 10 parts of calamus, 10 parts of scutellariae, 10 parts of angelica, 10 parts of rhizoma ligusticum, 10 parts of white peony root, 10 parts of rehmannia glutinosa, 10 parts of peach kernel, 10 parts of safflower, 10 parts of cyathulae, 10 parts of dipsacus and 10 parts of parasitic plant; The external use part includes the following components in parts by weight: 3 parts of Flying Dragon Palm Blood, 3 parts of Drynaria Bge, 3 parts of Epimedium, 3 parts of Ferula Ferula, 3 parts of Cyathula capitata, 3 parts of Zanthoxylum bungeanum and 3 parts of Aconitum.

4. A Chinese medicine composition for treating sequelae of stroke according to any one of claims 1 to 3, characterized in that: The oral part also includes: 10 parts of Uncaria rhynchophylla, 10 parts of Gardenia jasminoides, 10 parts of Paeonia suffruticosa root and 10 parts of Morus alba, and each component can float 20%.

5. A Chinese medicine composition for treating sequelae of stroke according to any one of claims 1 to 3, characterized in that: The oral part also includes: 10 parts of Pinellia tuber, 10 parts of Atractylodes macrocephala, 10 parts of Arisaema ciliata and 10 parts of Astragalus membranaceus, and each component can be floated by 20%.

6. A Chinese medicine composition for treating sequelae of stroke according to any one of claims 1 to 3, characterized in that: The oral part also includes: 10 parts of Trichosanthes kirilowii, 10 parts of Radix Ophiopogonis, 10 parts of Radix Polygoni Multiflori and 10 parts of Gastrodia elata, and each component can float up to 20%.

7. A Chinese medicine composition for treating sequelae of stroke according to any one of claims 1 to 3, characterized in that: The oral part also includes: 10 parts of Astragalus, 10 parts of Codonopsis, 10 parts of Hirudo and 10 parts of Lycopodiella ciliata, and each component can float 20%.

8. A method for preparing a Chinese medicine composition for treating sequelae of stroke according to any one of claims 1 to 7, characterized in that: The specific steps include: (1) weighing the raw materials of the oral portion and the external portion according to weight and setting aside; (2) Mix all the raw materials of the oral part, soak them in cold water, boil them in boiling water for 30-60 minutes, and filter them to obtain the medicinal juice, wherein the medicinal juice is controlled to be 200-300 ml; (3) The raw materials of the external application part are crushed to obtain a powder, and alcohol is added to the powder to prepare an external application ointment.

9. The method for preparing a Chinese medicine composition for treating sequelae of stroke according to claim 8, characterized in that: The cold water immersion time in step (2) is 2 hours, and the water is sufficient to immerse the medicine.

10. The method for preparing a Chinese medicine composition for treating sequelae of stroke according to claim 8, characterized in that: The mass volume ratio of the medicinal powder and the alcohol in step (3) is 21g:100ml.

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