A hydrophilic-hydrophobic heterogeneous wrinkle polymer microsphere, a preparation method and application thereof

The preparation of hydrophilic-hydrophobic heterostructured polymer microspheres by suspension-interface polymerization solves the problem of unsatisfactory surface morphology of polymer microspheres in the prior art, and achieves the preparation of microspheres with good particle size uniformity, which is suitable for catalysis, drug delivery, biosensing and other fields.

CN119613599BActive Publication Date: 2026-06-23SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Filing Date
2024-11-19
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Existing technologies make it difficult to prepare polymer microspheres with uniform hydrophilic-hydrophobic heterostructures. The surface morphology of polymer microspheres is not ideal, which makes it difficult to meet the application requirements of biomaterials and pharmacology.

Method used

By employing a suspension-interface polymerization method, hydrophilic monomers in an aqueous solution and hydrophobic monomers in an oil solution are assembled into suspended droplets under stirring conditions. The copolymerization reaction at the interface is then controlled by temperature to prepare microspheres with hydrophilic-hydrophobic heterostructures and surface wrinkles.

Benefits of technology

The prepared polymer microspheres exhibit good particle size uniformity and form a uniform wrinkled structure on the surface, which increases the specific surface area and makes them suitable for industrial production.

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Abstract

The application discloses a kind of hydrophilic-hydrophobic heterogeneous wrinkle polymer microspheres and its preparation method and application.The polymer microspheres of the application are prepared by suspension-interface polymerization based on oil phase solution and water phase solution, wherein the preparation raw materials of oil phase solution include hydrophobic monomer, swelling solvent and initiator, and the mass-volume ratio is 3-5 mL:1-4 mL:0.05-0.2 g;The preparation raw materials of water phase solution include water-soluble monomer, stabilizer and solvent, and the mass-volume ratio is 0.5-2 mL:1-2 g:75-100 mL.The polymer microspheres prepared by the method of the application have good particle size uniformity, and the surface of microsphere presents wrinkle morphology, has larger specific surface area, and can be applied in the fields of drug carrier, catalytic carrier or biosensor etc.
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