A multi-channel pulse ablation device

Abstract

The application provides a multi-channel pulse ablation device, relates to the technical field of medical treatment, is applied to a lung lesion tissue channel, the outer diameter of the pulse ablation device is less than the inner diameter of the lung lesion tissue channel, the pulse ablation device comprises a multi-lumen tube, an adjusting assembly, at least two groups of ablation catheter assemblies and flexible electrodes corresponding to each group of ablation catheter assemblies, the multi-lumen tube is used for accommodating the at least two groups of ablation catheter assemblies, the adjusting assembly is connected with each group of ablation catheter assemblies, and the ablation catheter assembly is connected with the flexible electrode, the at least two groups of ablation catheter assemblies can move along the axial direction of the multi-lumen tube, and the adjusting assembly is used for adjusting the position of each group of ablation catheter assemblies to adjust the position of the flexible electrode, so that the at least two groups of ablation catheter assemblies and the corresponding flexible electrodes can simultaneously ablate the target lesion tissue channel, the operation time is reduced, the treatment efficiency is improved, the process of repeatedly inserting and adjusting the catheter is avoided, and the repeated damage to the patient's tissue is reduced.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a multi-channel pulse ablation device. Background Technology

[0002] Irreversible electroporation (IRE) is a tissue ablation technique widely used to treat various natural cavity diseases, including thyroid diseases, urinary system diseases, esophageal diseases, intestinal diseases, COPD, lung cancer, liver cancer, and kidney cancer. Compared to traditional ablation techniques, IRE ablates and inactivates tissue at the cellular level, without damaging tissue structure or protein activity, and allows for precise control of the ablation area. IRE generates almost no heat during the ablation process, avoiding the heat deposition effect, minimizing the impact on surrounding blood vessels, and reducing procedure time and infection risk.

[0003] Despite the significant advantages of IRE technology, existing pulsed ablation devices still face numerous limitations in practical clinical applications. Current pulsed ablation devices require multiple ablation cycles during treatment, resulting in low efficiency. Furthermore, existing pulsed ablation devices generally rely on endoscopic bending for operation and positioning. Since lesions are often located within complex anatomical structures, the positioning of pulsed ablation devices in branching or deep lesions is often not precise enough, increasing the difficulty of the procedure and the risk of failure. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by providing a multi-channel pulse ablation device. This pulse ablation device, by adopting a multi-channel structure, can simultaneously deliver multiple ablation electrodes, and each ablation electrode can be independently positioned, thereby achieving simultaneous ablation of multiple electrodes and improving ablation efficiency and ablation effect.

[0005] This invention provides a multi-channel pulse ablation device for use in lung lesion tissue channels. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channels. The pulse ablation device includes a multi-lumen tube, an adjustment component, at least two sets of ablation catheter assemblies, and flexible electrodes corresponding to each set of ablation catheter assemblies.

[0006] The multi-lumen tube is used to accommodate the at least two sets of ablation catheter assemblies, the adjustment assembly is connected to each set of ablation catheter assemblies, and the ablation catheter assembly is connected to the flexible electrode;

[0007] The at least two sets of ablation catheter assemblies are capable of moving along the axial direction of the multi-lumen tube, and the adjustment assembly is used to adjust the position of each set of ablation catheter assemblies to adjust the position of the flexible electrode.

[0008] In a possible implementation, the pulse ablation device further includes a bending adjustment element and a bending adjustment valve;

[0009] The bending adjustment component is disposed between the multi-lumen tube and the at least two sets of ablation catheter assemblies, and the bending adjustment component is connected to the bending adjustment valve;

[0010] The bending adjustment valve can adjust the bending degree of the bending adjustment element to adjust the bending degree of the at least two sets of ablation catheter assemblies.

[0011] In a possible implementation, the ablation catheter assembly includes a guide core and a handle assembly;

[0012] The guide core is disposed between the flexible electrode and the handle assembly. The handle assembly is drivenly connected to the proximal end of the guide core, and the distal end of the guide core is elastically connected to the flexible electrode.

[0013] In a possible implementation, the stiffness of the distal end of the guide core is less than the stiffness of the proximal end of the guide core.

[0014] In a possible implementation, the ablation catheter assembly further includes a navigation line, and the guide core has a hollow structure for accommodating the navigation line.

[0015] In a possible implementation, the ablation catheter assembly includes an information collection device connected to the flexible electrode, the information collection device being used to acquire the position information and / or morphological data of the flexible electrode.

[0016] In a possible implementation, the ablation catheter assembly further includes a pulse cable and a pulse connector, the distal end of the pulse cable being connected to the flexible electrode, the proximal end of the pulse cable being placed in the pulse connector, and the pulse cable being connected to the pulse ablation system through the pulse connector.

[0017] In a possible implementation, the adjustment assembly includes an adjustment switch, a transmission mechanism, and a fine-tuning knob. The fine-tuning knob is connected to the adjustment switch via the transmission mechanism. The adjustment switch is used to switch the adjustment mode of the ablation catheter assembly.

[0018] In coarse adjustment mode, the ablation catheter assembly is capable of reciprocating along the axial direction of the multi-lumen tube within the multi-lumen tube;

[0019] In fine-tuning mode, the fine-tuning knob can drive the ablation catheter assembly to reciprocate along the axial direction of the multi-lumen tube via the transmission mechanism.

[0020] In a possible implementation, the stiffness of the distal end of the multi-lumen tube is less than the stiffness of the proximal end of the multi-lumen tube.

[0021] In a possible implementation, the outer diameter of the multi-lumen tube is 1mm-4mm.

[0022] The multi-channel pulse ablation device provided in this application has the following beneficial effects:

[0023] This application provides a multi-channel pulse ablation device, relating to the field of medical technology, applied to the lung lesion tissue channel. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel. The pulse ablation device includes a multi-lumen tube, an adjustment component, at least two sets of ablation catheter assemblies, and flexible electrodes corresponding to each set of ablation catheter assemblies. The multi-lumen tube accommodates at least two sets of ablation catheter assemblies, the adjustment component is connected to each set of ablation catheter assemblies, and the ablation catheter assemblies are connected to the flexible electrodes. At least two sets of ablation catheter assemblies can move axially along the multi-lumen tube, and the adjustment component is used to adjust the position of each set of ablation catheter assemblies to adjust the position of the flexible electrodes. In this way, at least two sets of ablation catheter assemblies and corresponding flexible electrodes can simultaneously ablate the target lesion tissue channel, reducing operation time, improving treatment efficiency, and avoiding the need for repeated insertion and adjustment of catheters, thus reducing repeated damage to the patient's tissue. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0025] Figure 1 This is a schematic diagram of the structure of a multi-channel pulse ablation device according to an embodiment of this application;

[0026] Figure 2 This is a schematic diagram of the structure of the first ablation catheter assembly according to an embodiment of this application;

[0027] Figure 3 This is a schematic diagram of the structure of the flexible electrode according to an embodiment of this application;

[0028] Figure 4 This is a schematic diagram of the structure of the guide core according to an embodiment of this application;

[0029] Figure 5 This is a schematic diagram of the structure of the adjustment component according to an embodiment of this application;

[0030] Figure 6 This is a cross-sectional view of a multi-channel pulse ablation device according to an embodiment of this application.

[0031] The following is supplementary explanation of the attached figures:

[0032] 1. First ablation catheter assembly; 11. Flexible electrode; 12. Guide core; 121. Distal end of guide core; 13. Information collection device; 14. Fixing component; 15. Pulse cable; 16. First ablation catheter; 2. Second ablation catheter assembly; 3. Multi-lumen tube; 4. Bending component; 41. Bending valve body; 42. Bending valve stem; 5. Adjustment assembly; 51. Adjustment switch; 52. Fine-tuning knob; 6. Handle assembly; 61. First handle; 7. Connector assembly. Detailed Implementation

[0033] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are merely some embodiments of the present application, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present application without creative effort are within the scope of protection of the present application.

[0034] The term "an embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of this application. In the description of this application, it should be understood that the terms "upper," "lower," "top," "bottom," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. Moreover, the terms "first," "second," etc., are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented in orders other than those illustrated or described herein.

[0035] Understandably, irreversible electroporation (IRE) is a novel tissue ablation technique. In this method, doctors guide a treatment device to the lesion site through skin puncture or intervention via natural cavities, and then treat the lesion with the ablation device. IRE is applicable to various natural cavity diseases, such as thyroid diseases, urinary system diseases, esophageal diseases, intestinal diseases, COPD, lung cancer, liver cancer, kidney cancer, etc. When biological tissue is placed in a high-intensity electric field, the permeability of the cell membrane increases significantly, causing extracellular fluid molecules to diffuse into the cell membrane and induce cell death, thereby achieving tissue ablation. During the ablation process, the lipid bilayer in the cell membrane breaks down under the high-intensity electric field, and the lipid bilayer changes with the electric field strength, treatment time, pulse period, and number of pulses. The ablation technique has evolved from early reversible electroporation to irreversible electroporation, and in recent years, irreversible electroporation has been applied to minimally invasive ablation of various tissues or tumors.

[0036] Compared to traditional tissue ablation techniques, such as radiofrequency ablation (RFA) and microwave ablation (MWA), IRE tissue ablation technology has many significant advantages. For example, IRE inactivates tissue at the cellular level, without affecting tissue structure or protein activity, and allows for precise control of the inactivation area. Furthermore, IRE generates very little heat during ablation, eliminating heat deposition and minimizing impact on local blood vessels. The short ablation time during IRE reduces tissue exposure time and the likelihood of infection complications. In addition, irreversible electroporation ablation can utilize medical imaging techniques such as computed tomography (CT), ultrasound, and magnetic resonance imaging (MRI) for ablation area localization, real-time treatment monitoring, and postoperative efficacy observation, making the IRE ablation range more precise and maximizing the protection of normal tissue.

[0037] In existing technologies, for tumor-related diseases, such as lung tumors, 2-6 electrodes are placed around the lesion tissue during surgery. However, this process is very time-consuming and the positioning may be inaccurate. Furthermore, delivering multiple ablation electrodes at the same time can increase the risk of complications for patients.

[0038] In view of this, in order to solve at least one of the above problems, this application provides a multi-channel pulse ablation device that simultaneously controls the position of multiple flexible electrodes 11 by setting at least two sets of ablation catheter assemblies. This device is particularly suitable for irreversible electroporation ablation technology.

[0039] The following description, in conjunction with the accompanying drawings, describes a multi-channel pulse ablation device provided by an embodiment of this application, applied to a lung lesion tissue channel. The outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel. The pulse ablation device includes a multi-lumen tube 3, an adjustment component 5, at least two sets of ablation catheter assemblies, and flexible electrodes 11 corresponding to each set of ablation catheter assemblies. The multi-lumen tube 3 is used to accommodate at least two sets of ablation catheter assemblies. The adjustment component 5 is connected to each set of ablation catheter assemblies, and the ablation catheter assemblies are connected to the flexible electrodes 11. At least two sets of ablation catheter assemblies can move along the axial direction of the multi-lumen tube 3. The adjustment component 5 is used to adjust the position of each set of ablation catheter assemblies to adjust the position of the flexible electrodes 11. In this way, at least two sets of ablation catheter assemblies and corresponding flexible electrodes 11 can simultaneously ablate the target lesion tissue channel, reducing operation time, improving treatment efficiency, and avoiding the need for repeated insertion and adjustment of catheters, thus reducing repeated damage to the patient's tissue.

[0040] Specifically, this embodiment provides a dual-channel pulse ablation device, which includes two sets of ablation catheter assemblies and two corresponding sets of flexible electrodes 11. The inner diameter of the multi-lumen tube 3 is greater than the sum of the inner diameters of at least two sets of ablation catheter assemblies. The multi-lumen tube 3 is used to deliver the ablation electrodes. The multi-lumen tube 3 has a first inner lumen and a second inner lumen. The first inner lumen is used to accommodate the first ablation catheter assembly 1, and the second inner lumen is used to accommodate the second ablation catheter assembly 2. The first ablation catheter assembly 1 is associated with a first flexible electrode, which is located at the distal end of the first ablation catheter assembly 1. The second ablation catheter assembly 2 is associated with a second flexible electrode, which is located at the distal end of the second ablation catheter assembly 2. An adjustment component 5 is disposed on the multi-lumen tube 3. The adjustment component 5 can independently adjust the position of the first ablation catheter assembly 1 and the second ablation catheter assembly 2 relative to the multi-lumen tube 3, thereby adjusting the position between the first flexible electrode and the second flexible electrode and the target lesion tissue.

[0041] In another possible implementation, the multi-channel pulse ablation device is a three-channel pulse ablation device.

[0042] Specifically, the first inner cavity has a first axis, the second inner cavity has a second axis, and the multi-cavity tube 3 has a preset axis. The first axis, the second axis, and the preset axis are parallel to each other.

[0043] Specifically, the pulse ablation system is connected to a multi-channel pulse ablation device. The pulse energy emitted by the pulse ablation system travels from the pulse ablation device to the flexible electrode 11 to reach the target lesion tissue, thereby achieving the therapeutic effect.

[0044] In one possible implementation, at least two sets of ablation catheter assemblies correspond to at least two sets of flexible electrodes 11, wherein at least one pair of flexible electrodes 11 forms an electrode circuit.

[0045] Specifically, the flexible electrode 11 is used to form single-level and multi-level pathways. In one possible implementation, the first and second flexible electrodes are used to form a single-level pathway, and the first and second flexible electrodes respectively form corresponding current pathways with the surface electrodes adhered to the human body surface. In another possible implementation, the first and second flexible electrodes are used to form a multi-level pathway, and the first and second flexible electrodes form corresponding current pathways that act on the target lesion tissue.

[0046] Specifically, the flexible electrode 11 has a mesh structure, which is formed by multiple electrode lines interlaced and woven into a mesh. The flexible electrode 11 can change shape, and it can open and close. As a result, the mesh density, tensile properties and structural stability of the flexible electrode 11 are higher, which allows it to better fit the target lesion tissue, and the fitting area is larger and more uniform, resulting in better treatment effect.

[0047] Furthermore, the pulse ablation device also includes a bending adjustment element 4 and a bending adjustment valve; the bending adjustment element 4 is disposed between the multi-lumen tube 3 and at least two sets of ablation catheter assemblies, and the bending adjustment element 4 is connected to the bending adjustment valve; the bending adjustment valve can adjust the curvature of the bending adjustment element 4 to adjust the curvature of at least two sets of ablation catheter assemblies. By independently adjusting the curvature of each set of ablation catheter assemblies through the bending adjustment valve, synchronous ablation in multiple regions and directions can be achieved, improving the accuracy of positioning and the flexibility of operation.

[0048] Specifically, in the embodiments of this specification, the bending element 4 is a bending wire, and the bending wire is a multi-lumen tube 3 that also has a third inner cavity for accommodating the bending wire. The bending valve is connected to the bending wire and includes a bending valve body 41 and a bending valve stem 42. The bending valve body 41 is connected to the proximal end of the multi-lumen tube 3. By rotating the bending valve stem 42, the bending wire changes its curvature along with the bending valve stem 42, thereby changing the curvature of the multi-lumen tube 3. Consequently, the curvature of at least two sets of ablation catheter assemblies changes with the curvature of the multi-lumen tube 3. The bending valve enables controllable bending of the bending element 4, allowing the pulse ablation device to conform to the complex curvature of the lung lesion tissue channel, making it suitable for complex areas such as branch bronchi or deep lesions.

[0049] Specifically, the first ablation catheter assembly 1 includes a first ablation catheter 16, which is used to cover the first guide core and the first cable. The second ablation catheter assembly 2 includes a second ablation pin, which is used to accommodate the second guide core and the second cable. The multi-lumen tube 3 accommodates the first ablation catheter 16 and the second ablation pin. The first flexible electrode and the second flexible electrode are exposed at the distal end of the multi-lumen tube 3.

[0050] Specifically, the ablation catheter assembly includes a guide core 12 and a handle assembly. The guide core 12 is disposed between the flexible electrode 11 and the handle assembly. The handle assembly is connected to the proximal end of the guide core 12, and the distal end of the guide core 12 is elastically connected to the flexible electrode 11. Thus, the guide core 12 allows for adjustment of the expansion, contraction, and fine-tuning of the flexible electrode 11, enabling rapid correction of the flexible electrode 11's position and increasing positioning accuracy.

[0051] Specifically, the ablation catheter assembly includes a guide core 12 and a pulse cable 15. The handle assembly includes a first handle 61 and a second handle. The first handle 61 is used to bend the first flexible electrode to adjust its shape and position, and the second handle is used to bend the second flexible electrode to adjust its shape and position. When adjusting the first ablation catheter assembly 1, a pulling or pushing force is applied to the first flexible electrode by rotating the first control member of the first handle 61, thereby changing the curvature of the first flexible electrode. The first handle 61 can also open or close the first flexible electrode. When adjusting the second ablation catheter assembly 2, a pulling or pushing force is applied to the second flexible electrode by rotating the second control member of the second handle, thereby changing the curvature of the second flexible electrode. The second handle can also open or close the second flexible electrode.

[0052] Specifically, a first insulating element is provided between the first handle 61 and the first ablation catheter assembly 1, and a second insulating element is provided between the second handle and the second ablation catheter assembly 2.

[0053] Specifically, a first control element is provided on the first handle 61, and the first control element is slidably or rotatably connected to the first handle 61. A second control element is provided on the second handle, and the second control element is slidably or rotatably connected to the second handle.

[0054] Specifically, the stiffness of the distal end of the guide core 12 is less than that of the proximal end. This results in greater flexibility at the distal end of the guide core 12, allowing it to easily adapt to the complex anatomical structures within the human body. This facilitates safe passage through narrow or irregular channels and also helps the ablation catheter to conform more naturally to the target tissue during fine-tuning, making it easier to adjust the angle of the ablation catheter and improving the accuracy of positioning and manipulation.

[0055] Preferably, the distal end of the guide core 12 is made of a biocompatible metal such as medical stainless steel or nickel-titanium alloy.

[0056] Specifically, the guide core 12 is a metal wire structure or a metal tube structure. In one possible implementation, the distal end of the guide core 12 is a spring structure, and the proximal end of the guide core 12 is a metal tube structure.

[0057] In another embodiment, the distal end of the guide core 12 is a thiouret tube structure, a snake bone structure, a braided tube structure, or a corrugated tube structure, so as to realize the function of delivery and bending adjustment of the distal end of the ablation catheter assembly in the curved or bifurcated anatomical structure of the guide core 12.

[0058] Optionally, the sheath is a multi-cavity composite structure of metal and polymer, which has good bending performance; the polymer tubing is preferably made of polyetheramide, nylon, thermoplastic polyurethane, polyimide, polytetrafluoroethylene, etc.

[0059] In one possible implementation, the distal and proximal ends of the guide core 12 are manufactured as a single unit on the basis of a complete tube using processes such as laser cutting. Alternatively, the distal and proximal ends of the guide core 12 can be manufactured separately using assembly methods such as welding, snap-fitting, or threading.

[0060] Furthermore, the ablation catheter assembly also includes a navigation line, and the guide core 12 has a hollow structure to accommodate the navigation line. Thus, the hollow structure of the guide core 12 ensures that the navigation line is stably accommodated and guided, preventing it from deviating due to external forces or unstable factors, thereby improving the accuracy of the navigation line's guidance to the target lesion.

[0061] Specifically, the ablation catheter assembly includes a navigation line and a sensing connector. The navigation line is electrically connected to the information collection device 13, and the sensing connector is communicatively connected to the pulse ablation system. The navigation line is used to transmit the position information of the flexible electrode 11.

[0062] Furthermore, the ablation catheter assembly includes an information collection device 13, which is connected to the flexible electrode 11. The information collection device 13 is used to acquire the position information and / or morphological data of the flexible electrode 11. The information collection device 13 can monitor the position of the flexible electrode 11 in real time, ensuring accurate positioning of the lesion during the operation, reducing the risk of misoperation, and accurately understanding the morphology and position of the flexible electrode 11, ensuring that the electrode adheres closely to the target tissue, and improving the uniformity of energy transfer and ablation efficiency.

[0063] Specifically, the information collection device 13 is mounted on the fixing member 14, and the distal end of the flexible electrode 11 is fixedly connected to the fixing member 14. The ablation catheter assembly includes a navigation line and a sensing connector. The navigation line is electrically connected to the information collection device 13, and the sensing connector is communicatively connected to the pulse ablation system. In this embodiment, the fixing member 14 is a fixing sleeve.

[0064] Specifically, the pulse ablation device can determine the relative position of the flexible electrode 11 with the target lesion tissue and patient structure in real time, avoid deviation in the delivery of the flexible electrode 11, improve positioning accuracy, reduce the frequency of confirmation by intraoperative computed tomography (CT), eliminate the need for repeated adjustments, reduce the possibility of serious complications, and improve safety.

[0065] In one embodiment, the information collection device 13 is a positioning sensor that can be combined with an electromagnetic positioning three-dimensional navigation system; in another embodiment, the information collection device 13 is a shape-sensing optical fiber that can monitor the shape data of the flexible electrode in real time.

[0066] Specifically, when the information collection device 13 is a positioning sensor, the positioning sensor is connected to the electromagnetic positioning three-dimensional navigation system. The electromagnetic positioning three-dimensional navigation system can track the position of the flexible electrode in real time and display the coordinates of the flexible electrode in three-dimensional space. Then, the operator adjusts the direction of the flexible electrode according to the position displayed in real time by the electromagnetic positioning three-dimensional navigation system to ensure that the flexible electrode can correctly contact the target lesion tissue.

[0067] Furthermore, the ablation catheter assembly also includes a pulse cable 15 and a pulse connector. The distal end of the pulse cable 15 is connected to the flexible electrode 11, and the proximal end of the pulse cable 15 is placed in the pulse connector. The pulse cable 15 is connected to the pulse ablation system through the pulse connector. In this way, the pulse cable 15 can stably transmit high-frequency pulse energy to the flexible electrode 11, and can also integrate bidirectional transmission of electrode monitoring signals, improving energy utilization and ablation efficiency.

[0068] Specifically, the pulse cable 15 is electrically connected to the flexible electrode 11, the ablation catheter assembly is connected to the pulse connector, the distal end of the pulse connector is connected to the ablation catheter assembly, the proximal end of the pulse connector is connected to the pulse ablation system for communication, and a pulse connector is provided at the proximal end of the pulse connector.

[0069] Specifically, the first ablation catheter assembly 1 includes a first pulse cable 15 and a first pulse connector, and the second ablation catheter assembly 2 includes a second pulse cable 15 and a second pulse connector. The pulse ablation system can independently control the first ablation catheter assembly 1 and the second ablation catheter assembly 2.

[0070] Specifically, in the embodiments of this specification, the pulse ablation device includes a connector assembly 7, which includes a sensing connector and a pulse connector.

[0071] Specifically, the adjustment component 5 includes an adjustment switch 51, a transmission mechanism, and a fine-tuning knob 52. The fine-tuning knob 52 is connected to the adjustment switch 51 via the transmission mechanism. The adjustment switch 51 is used to switch the adjustment mode of the ablation catheter assembly. In coarse adjustment mode, the ablation catheter assembly can reciprocate along the axial direction of the multi-lumen tube 3 within the multi-lumen tube 3. In fine adjustment mode, the fine-tuning knob 52, through the transmission mechanism, can drive the ablation catheter assembly to reciprocate along the axial direction of the multi-lumen tube 3. In this way, the ablation catheter assembly can move rapidly and significantly along the axial direction of the multi-lumen tube 3, and can also achieve precise axial movement through the transmission mechanism of the fine-tuning knob 52. This allows the operator to flexibly respond to the operational needs at different stages without changing instruments or performing complex operations, significantly improving surgical efficiency.

[0072] Specifically, the adjustment component 5 includes a Y-type valve. In the embodiments described in this specification, the adjustment component 5 includes a first adjustment switch 51, a first transmission mechanism, a first fine-tuning knob 52, a second adjustment switch 51, a second transmission mechanism, and a second fine-tuning knob 52. The first adjustment switch 51, the first transmission mechanism, and the first fine-tuning knob 52 are used to adjust the first ablation catheter assembly 1, and the second adjustment switch 51, the second transmission mechanism, and the second fine-tuning knob 52 are used to adjust the second ablation catheter assembly 2.

[0073] Specifically, for the first ablation catheter assembly 1, in coarse adjustment mode, the operator manually adjusts the position of the first ablation catheter assembly 1; in fine adjustment mode, the operator first turns on the fine adjustment switch, and then rotates the first fine adjustment knob 52. The first fine adjustment knob 52 and the first transmission mechanism are driven by a threaded structure. Through the engagement of the threads, the rotational power is transmitted to the first ablation catheter assembly 1, causing it to produce linear motion. For the second ablation catheter assembly 2, in coarse adjustment mode, the operator manually adjusts the position of the second ablation catheter assembly 2; in fine adjustment mode, the operator first turns on the fine adjustment switch, and then rotates the second fine adjustment knob 52. The second fine adjustment knob 52 and the second transmission mechanism are driven by a threaded structure. Through the engagement of the threads, the rotational power is transmitted to the second ablation catheter assembly 2, causing it to produce linear motion.

[0074] Specifically, the stiffness of the distal end of the multi-lumen tube 3 is less than that of the proximal end. This results in greater flexibility at the distal end of the multi-lumen tube 3, allowing it to adapt to the bending characteristics of the lungs or other complex anatomical regions. This helps the flexible electrode 11 to better conform to the surface of the target lesion tissue, ensuring that ablation energy is released uniformly and precisely, thus improving treatment efficacy.

[0075] Specifically, the multi-lumen tube 3 and at least two sets of ablation catheter assemblies can be delivered via bronchoscopic intervention for the treatment of natural cavity diseases. The multi-lumen tube 3 is a composite multi-lumen structure of metal and polymer, and the stiffness of the multi-lumen tube 3 gradually decreases from the proximal end to the distal end.

[0076] Preferably, the metal material in the multi-lumen tube 3 is medical stainless steel or nickel-titanium alloy, etc.; the polymer material is polyetheramide, nylon, thermoplastic polyurethane, polyimide or polytetrafluoroethylene, etc.

[0077] Specifically, the outer diameter of the multi-lumen tube 3 is 1mm-4mm. In this way, the multi-lumen tube 3 can accommodate at least two sets of ablation catheter components and can also cooperate with the lung lesion tissue channel. The multi-lumen tube 3 can accurately reach the target area, ensuring that the ablation catheter directly acts on the diseased tissue, thereby improving the reliability and stability of the overall treatment.

[0078] Specifically, the outer diameter of the multi-lumen tube 3 is smaller than the inner diameter of the target lesion tissue channel, and the outer diameter of the multi-lumen tube 3 is larger than the sum of the inner diameters of at least two ablation catheters.

[0079] Preferably, the wall thickness of the multi-lumen tube 3 is 0.025mm-0.1mm.

[0080] The following describes the working process of the multi-channel pulse ablation device in a specific application scenario:

[0081] First, the first ablation catheter assembly 1 and the second ablation catheter assembly 2 are inserted into the interior of the multi-lumen tube 3;

[0082] Then, the multi-lumen tube 3 is pushed through the working channel of the bronchoscope and gradually enters the target lesion tissue location. Using electromagnetic positioning technology, the positions of the first flexible electrode and the second flexible electrode are tracked in real time to determine the position of each flexible electrode 11 relative to the bronchial anatomy structure, and each flexible electrode 11 is guided to the target lesion tissue location quickly along the optimal navigation path.

[0083] Subsequently, if it is necessary to make precise adjustments to the position of the ablation electrodes, adjust the adjustment switch 51 on the handle assembly to switch the adjustment assembly 5 to the fine adjustment mode, and use the fine adjustment knob 52 to make fine displacement operations on each ablation catheter assembly to ensure that each flexible electrode 11 is precisely aligned with the target lesion tissue.

[0084] Finally, after the location is determined, the treatment is initiated at the target lesion site to ablate the target lesion tissue using pulsed energy.

[0085] The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A multi-channel pulse ablation device, applied to a lung lesion tissue channel, wherein the outer diameter of the pulse ablation device is smaller than the inner diameter of the lung lesion tissue channel, characterized in that, The pulse ablation device comprises a multi-lumen tube, an adjusting assembly, at least two groups of ablation catheter assemblies and flexible electrodes corresponding to each group of ablation catheter assemblies; The multi-lumen tube is used for accommodating the at least two groups of ablation catheter assemblies, the adjusting assembly is connected with each group of the ablation catheter assemblies, and the ablation catheter assemblies are connected with the flexible electrodes; The at least two groups of ablation catheter assemblies can move along the axial direction of the multi-lumen tube, and the adjusting assembly is used for adjusting the position of each group of the ablation catheter assemblies to adjust the position of the flexible electrodes; The pulse ablation device further comprises a bending adjusting part (4) and a bending adjusting valve; The bending adjusting part (4) is arranged between the multi-lumen tube (3) and the at least two groups of ablation catheter assemblies, and the bending adjusting part (4) is connected with the bending adjusting valve; The bending adjusting valve can adjust the bending degree of the bending adjusting part (4) to adjust the bending degree of the at least two groups of ablation catheter assemblies; The ablation catheter assembly comprises a guide inner core (12) and a handle assembly (6); The guide inner core (12) is arranged between the flexible electrode (11) and the handle assembly (6), the handle assembly (6) is in transmission connection with the proximal end of the guide inner core (12), and the distal end of the guide inner core (12) is in elastic connection with the flexible electrode (11); The ablation catheter assembly further comprises a navigation wire, the guide inner core (12) is in a hollow structure, and the guide inner core (12) is used for accommodating the navigation wire; The ablation catheter assembly comprises an information collecting device (13), the information collecting device (13) is connected with the flexible electrode (11), and the information collecting device (13) is used for acquiring position information of the flexible electrode (11) and / or shape data of the flexible electrode (11); The handle assembly comprises a first handle and a second handle, the first handle is used for bending a first flexible electrode to adjust the shape and position of the first flexible electrode, and the second handle is used for bending a second flexible electrode to adjust the shape and position of the second flexible electrode.

2. The multi-channel, pulsed ablation device of claim 1, wherein, The rigidity of the distal end of the guide inner core is smaller than the rigidity of the proximal end of the guide inner core.

3. The multi-channel, pulsed ablation device of claim 1 or 2, wherein, The ablation catheter assembly further comprises a pulse cable (15) and a pulse connector, the distal end of the pulse cable (15) is connected with the flexible electrode (11), the proximal end of the pulse cable (15) is accommodated in the pulse connector, and the pulse cable (15) is connected with a pulse ablation system through the pulse connector.

4. The multi-channel, pulsed ablation device of claim 1 or 2, wherein, The adjusting assembly (5) comprises an adjusting switch (51), a transmission mechanism and a fine adjustment knob (52), the fine adjustment knob (52) is connected with the adjusting switch (51) through the transmission mechanism, and the adjusting switch (51) is used for switching the adjusting mode of the ablation catheter assembly; In the coarse adjustment mode, the ablation catheter assembly can reciprocate along the axial direction of the multi-lumen tube (3) in the multi-lumen tube (3); In the fine adjustment mode, the fine adjustment knob (52) can drive the ablation catheter assembly to reciprocate along the axial direction of the multi-lumen tube (3) through the transmission mechanism.

5. The multi-channel, pulsed ablation device of claim 1 or 2, wherein, The rigidity of the distal end of the multi-lumen tube (3) is smaller than the rigidity of the proximal end of the multi-lumen tube (3).

6. The multi-channel, pulsed ablation device of claim 1 or 2, wherein, The outer diameter of the multi-lumen tube (3) is 1-4 mm.

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